ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1573-739X
    Keywords: Dissolution ; Mesalazine ; Tablets, controlled release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In vitro dissolution profiles of three controlled-release mesalazine formulations were determined at pH 1.0, 6.0 and 7.5. A closed-column type dissolution apparatus was used. A reproducible gradual dissolution profile was seen for Pentasa® at all pH values. Dissolution starts immediately and is complete after 20 h. Dissolution profiles at pH 1 and pH 7.5 are much alike and dissolution is faster than at pH 6. The behaviour of Asacol® at different pH values corresponds with the expectations: no release at pH 6 and pH 1, fast release at pH 7.5. Dissolution starts after 1 h and is complete after 3 h. Mesalazine release from Salofalk® tablets at pH 7.5 and pH 6.0 starts after 2 and 3 h, respectively, and is complete after 5 and 10 h. However, after a long lag-time (10 h) mesalazine is also released from Salofalksu® tablets at pH 1 and dissolution is complete after 23 h.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1573-739X
    Keywords: Chemistry, analytical ; Chromatography, high pressure liquid ; Decomposition products ; Drug stability ; Ophthalmic solutions ; Pilocarpine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A rapid high-resolution high pressure liquid chromatographic method was developed for assaying pilocarpine. Pilocarpine in ophthalmic solutions decomposes fairly rapidly to give isopilocarpine, pilocarpic acid and isopilocarpic acid. The quality of an ophthalmic solution can be assessed by assaying these decomposition products. Existing high pressure liquid chromatographic methods suffer from long analysis times and poor resolution. The new method uses as the mobile phase 6 ml/l of triethylamine in water (pH 2.3, adjusted with 85% phosphoric acid) at a flow of 1.5 ml/min and as the stationary phase a C18-silica 125×4,6 mm column. 2-Amino-1phenyl-1,3-propanediol is used as an internal standard. Complete separation was obtained within 8 min. Pilocarpine eye drops were stored under different conditions and then analysed for decomposition products. During heat treatment, decomposition to isopilocarpine predominated over decomposition to pilocarpic or isopilocarpic acid. However, when stored at room temperature or in a refrigerator, formation of pilocarpic acid clearly prevailed. Thus, from assessment of decomposition products, the cause of decomposition can be established.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1573-739X
    Keywords: Cystic fibrosis ; Pharmacokinetics ; Pseudomonas aeruginosa ; Tobramycin ; Biotransformation ; Kidney ; Liver ; Menadione ; Toxicology ; Aciclovir ; Desciclovir ; Drug therapy, combination ; Glomerulonephritis ; Hepatitis B ; Interferon alpha ; Cobalamin ; Folic acid ; Hematopoiesis ; Homocysteine ; Leukemia ; Nitrous oxide ; Vitamin B12 ; Cisplatin ; Clinical trials ; Drug evaluation ; Neuropathy, sensory ; Org 2766 ; Preventive medicine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 12 (1990), S. 217-227 
    ISSN: 1573-739X
    Keywords: Antineoplastic agents ; Drug compounding ; Drug contamination ; Exposure, occupational ; Health-care personnel ; Mutagenicity tests ; Occupational health ; Protective devices
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Results of various biological and physical/chemical tests of the urines or blood of health-care personnel working with cytotoxic drugs are discussed. The outcomes of these tests are conflicting and inconclusive. The physical/chemical tests seem to be an alternative method. However, until now it has not been possible to establish the threshold concentration in urine or blood beneath which no effect has to be expected. Therefore, the interpretation of the concentration of cytotoxic drugs and/or the metabolites in the urine or blood is difficult. As long as one will not be able to provide conclusive data on the health hazards when working with cytotoxic drugs, protective measures have to be taken in order to lower the risk as much as possible.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 12 (1990), S. 247-251 
    ISSN: 1573-739X
    Keywords: Children ; Drug utilization ; Epidemiologic methods ; Greece ; Sick role
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The way in which drugs are used is a result of structural factors, such as the pharmaceutical market and the system of professional health care, and of ideological ones, such as definitions of health and sickness, and perceptions about drugs and symbolic meanings attached to them. The foundations for ideological factors related to drug use are suspected to be created in childhood through personal and culturally shaped experiences related to health and sickness, with implications for adult health and illness behaviour. It is therefore important to explore the perceptions that children themselves have of medications, including the role that they play in children's ideas about therapeutic measures to be taken when they are sick. Sixty healthy Greek children, aged six and seven years, were individually interviewed about drawings they had made depicting themselves the last time they had been sick or not felt well. The content of their narratives was analysed for references to medications according to words which they used (e.g., by general description, by type of medication, by brand name), the spontaneity of their responses, attitudes expressed about the necessity of drugs for recovery, and descriptions of the process of being sick (ideas of causation, necessary behavioural changes, therapeutic measuresetc.). Almost half of the children depicted and described themselves as alone while sick, often feeling isolated or denied access to regular activity; medications were seen as a way to resume normal activities and responsibilities. Illness was described as sudden in its onset, and a distinction was made between serious illness, which requires both a change in behaviour and the use of medication, and a ‘light’ illness, which does not. Alternatives or supplements to medication were stated by almost all the children (e.g., teas, soups, boiled rice) as part of their therapeutical regimen. The findings are discussed with respect to the context of Greek culture.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 12 (1990), S. 228-235 
    ISSN: 1573-739X
    Keywords: Antineoplastic agents ; Drug compounding ; Drug contamination ; Health-care personnel ; Occupational health ; Protective devices ; Waste products
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Presuming that preparation of antineoplastic drugs without proper protection may lead to mutagenic urine (of which the effects are uncertain), one has to take great care when preparing these drugs. Apart from Norway no other country has national regulations issued by the government for handling cytostatic agents. Many organizations in various countries have made their own guidelines, which may be adapted to the situations in local hospitals. The following recommendations have been compiled after a review of the literature. They reflect a personal set of guidelines for preparation, administration and disposal of cytotoxic drugs. They are probably the minimum precautions that should be taken, and have not been approved by any committee or agency. Further precautions must first have their potential benefit weighed against probable inconvenience and additional costs.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 12 (1990), S. 236-239 
    ISSN: 1573-739X
    Keywords: Chemistry, organic ; Histamine ; Histamine H1 agonists ; Histamine H1 antagonists ; Pharmacology ; 2-Phenylhistamine ; Synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In this article the synthesis and histaminergic H1 activity of a series of substituted 2-phenylhistamines are described. It appeared that substitution of the phenyl ring of these compounds influences the H1 activity substantially. In general, substitution inpara position causes a decrease in h1 activity. However, in themeta-substituted members both increases and decreases of H1 activity have been observed; thus themeta nitro andmeta methoxy derivatives are four times as potent as the parent 2-phenylhistamine. As far as investigated, neither H1 nor H3 activity could be established.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 12 (1990), S. 256-259 
    ISSN: 1573-739X
    Keywords: Cell survival ; Cytotoxins ; Glutathione ; Liver ; Proteins ; Rats ; Models ; molecular ; Receptors ; adenosine ; Structure—activity relationship
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1573-739X
    Keywords: Adsorption ; Drug stability ; Parenteral nutrition ; Somatostatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The stability of somatostatin, added to a total parenteral nutrition formula, in glass containers and in plastic ethylene vinyl acetate containers was investigated. The somatostatin concentration decreased immediately from 3μg/ml to 0.3–0.6μg/ml after addition to the emulsion. In spite of this rapid decrease, somatostatin concentrations remained stable with values of 0.4–0.7μg/ml during the follow-up period (24 h). These findings could be explained assuming adsorption to the surface of the container.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1573-739X
    Keywords: Chromatography, high pressure liquid ; Clearance ; Metabolism ; Pharmacokinetics ; Sulfaphenazole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, 〈 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...