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  • Articles  (4)
  • Triticum aestivum
  • fish
  • gene expression
  • Springer  (4)
  • 1995-1999  (4)
  • Physics  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Nuclear Control of Respiratory Chain Expression in Mammalian Cells (1997)
    Springer
    Journal of bioenergetics and biomembranes 29 (1997), S. 109-119 
    Details
    ISSN: 1573-6881
    Keywords: ETS domain ; gene expression ; mammalian cells ; mitochondria ; nuclear respiratory factors ; oxidative phosphorylation ; regulation ; respiratory chain ; transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The majority of gene products required for mitochondrial respiratory function are encoded in the nuclear genome. These include most of the respiratory subunits and all of the proteins that regulate the mitochondrial genetic system. One approach to understanding nucleo-mitochondrial interactions in mammalian cells is to identify the nuclear transcription factors that are common to the expression of these gene products. This has led to the purification and molecular cloning of nuclear respiratory factors, NRF-1 and NRF-2. The DNA binding and transcriptional specificities of these proteins have implicated them in the expression of many respiratory subunits along with key components of the mitochondrial transcription, replication, and heme biosynthetic machinery. In addition, tissue-specific transcription factors have been linked to the coordinate synthesis of contractile proteins and muscle-specific respiratory subunits whereas other more ubiquitous factors may have a dual function in nuclear and mitochondrial gene activation. These findings provide a framework for further investigations of the nuclear genetic mechanisms that integrate the expression of the respiratory apparatus with that of other cellular systems during growth and development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022681828846
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  • 2
    Electronic Resource
    Electronic Resource
    Glycine decarboxylase: Protein chemistry and molecular biology of the major protein in leaf mitochondria (1995)
    Springer
    Journal of bioenergetics and biomembranes 27 (1995), S. 407-414 
    Details
    ISSN: 1573-6881
    Keywords: Glycine decarboxylase ; mitochondria ; photorespiration ; gene expression ; light control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The four component proteins of the glycine decarboxylase multienzyme complex (the P-, H-, T-, and L-proteins) comprise over one-third of the soluble proteins in mitochondria isolated from the leaves of C3 plants. Together with serine hydroxymethyltransferase, glycine decarboxylase converts glycine to serine and is the site of photorespiratory CO2 and NH3 release. The component proteins of the complex are encoded on nuclear genes with N-terminal presequences that target them to the mitochondria. The isolated complex readily dissociates into its component proteins and reassociates into the intact complexin vitro. Because of the intimate association between photosynthesis and photorespiration, the proteins of the complex are present at higher levels in leaves in the light. The expression of these genes is controlled at the transcriptional level and the kinetics of expression are closely related to those of the small subunit of Rubisco. Deletion analysis of fusions between the promoter of the H-protein of the complex and the reporter gene β-glucuronidase in transgenic tobacco has identified a region responsible for the tissue specificity and light dependence of gene expression. Gel shift experiments show that a nuclear protein in leaves binds to this region. Glycine decarboxylase has proven to be an excellent system for studying problems in plant biochemistry ranging from protein-protein interactions to control of gene expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02110003
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  • 3
    Electronic Resource
    Electronic Resource
    Uncoupling Protein 3: Its Possible Biological Role and Mode of Regulation in Rodents and Humans (1999)
    Springer
    Journal of bioenergetics and biomembranes 31 (1999), S. 467-473 
    Details
    ISSN: 1573-6881
    Keywords: Uncoupling proteins ; fatty acids ; skeletal muscle ; brown adipose tissue ; obesity ; thermogenesis ; gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The recently discovered uncoupling protein 3 (UCP3) is highly homologous to the mitochondrialinner membrane protein UCP1, which generates heat by uncoupling the respiratory chainfrom oxidative phosphorylation. The thermogenic function of UCP1 protects against cold andregulates the energy balance in rodents. We review in vitro studies investigating the uncouplingactivity of UCP3 and in vivo studies, which address UCP3 gene expression in brown adiposetissue and skeletal muscle under various metabolic conditions. The data presented are, for themost, consistent with an uncoupling role for UCP3 in regulatory thermogenesis. We alsodiscuss mediators of UCP3 regulation and propose a potential role for intracellular fatty acidsin the mechanism of UCP3 modulation. Finally, we hypothesize a role for UCP3 in themetabolic adaptation of the mitochondria to the degradation of fatty acids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005448423731
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  • 4
    Electronic Resource
    Electronic Resource
    A Connectionist Model of Left-Right Sound Discrimination by the Mauthner System (1999)
    Springer
    Journal of computational neuroscience 6 (1999), S. 121-144 
    Details
    ISSN: 1573-6873
    Keywords: Mauthner ; escape ; artificial neural networks ; connectionism ; acoustic ; localization ; auditory ; fish ; goldfish ; XNOR model ; phase model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Medicine , Physics
    Notes: Abstract Artificial neural networks were used to explore the auditory function of the Mauthner system, the brainstem circuit in teleost fishes that initiates fast-start escape responses. The artificial neural networks were trained with backpropagation to assign connectivity and receptive fields in an architecture consistent with the known anatomy of the Mauthner system. Our first goal was to develop neurally specific hypotheses for how the Mauthner system discriminates right from left in the onset of a sound. Our model was consistent with the phase model for directional hearing underwater, the prevalent theory for sound source localization by fishes. Our second goal was to demonstrate how the neural mechanisms that permit sound localization according to the phase model can coexist with the mechanisms that permit the Mauthner system to discriminate between stimuli based on amplitude. Our results indicate possible computational roles for elements of the Mauthner system, which has provided us a theoretical context within which to consider past and future experiments on the cellular physiology. Thus, these findings demonstrate the potential significance of this approach in generating experimentally testable hypotheses for small systems of identified cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008828501676
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