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1

Digitale Medien

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization (1998)

Bajou, K. ; Noël, A. ; Gerard, R.D. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 923-928

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Acquisition of invasive/metastatic potential through protease expression is an essential event in tumor progression. High levels of components of the plasminogen activation system, including urokinase, but paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI1), have been ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-923

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2

Digitale Medien

T-cell independent IgM and enduring protective IgG antibodies induced by chimeric measles viruses (1998)

Fehr, Thomas ; Naim, Hussein Y. ; Bachmann, Martin F. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 945-948

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] B-cell activation depends on the intensity of B-cell receptor cross-linking. Studies of haptenated antigens1 and vesicular stomatitis virus2 (VSV) have demonstrated a correlation between antigen repetitiveness and the degree to which B-cell activation is independent of T cells. Here, we compare ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-945

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3

Digitale Medien

The Neurobiology of Suicide (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 973-973

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] From the bench to the clinic (Annals of the New York Academy of Sciences, vol. 836) Edited by David M. Stoff & J. John Mann The New York Academy of Sciences, $80, 365 pp. ISBN1-57331 095-6, 1998 Reviewed By Angelo S. Halaris Department of Psychiatry, University of Mississippi, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-973

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4

Digitale Medien

Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa (1998)

Lewin, Alfred S. ; Drenser, Kimberly A. ; Hauswirth, William W. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 967-971

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Ribozymes, catalytic RNA molecules that cleave a complementary mRNA sequence, have potential as therapeutics for dominantly inherited disease. Twelve percent of American patients with the blinding disease autosomal dominant retinitis pigmentosa (ADRP) carry a substitution of histidine for proline ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-967

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5

Digitale Medien

The Genetics of Cancer (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 974-974

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Genes associated with cancer Invasion, Metastasis and cell proliferation G.V. Sherbet & M.S. Lakshmi Academic Press, $85, 352 pp. ISBN: 0-126-39875-5, 1997 Reviewed By Daniel A. Haber Massachusetts General Hospital Cancer Center and Harvard Medical School,Charlestown, MA 02129 The ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-974a

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6

Digitale Medien

Erratum (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 974-974

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease Øyvind Molberc, Stephen N. Mcadam, Roman Korner, Hanne Quarsten, Christel Kristiansen, Lars Madsen, Lars Fuccer, Helce Scott, Ove Noren, Peter Roepstorff, Knut E.A. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-974b

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7

Digitale Medien

Amyloid and Alzheimer disease (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 745-745

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Over the last decade or so, the number of papers listed by the US National Library of Medicine with the word Alzheimer in their title has grown steadily—in all, some twelve thousand are listed. Yet despite this level of activity and the fact that this disease, thought to represent the most ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-745

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8

Digitale Medien

Vaccine reactions (1998)

Francis, Donald P. ; Nowinski, Robert C.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 746-746

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—Burton and Moore claim that “The experience of the biopharmaceutical companies in the HIV vaccine area has not been a happy one …. Interpretive loophole are ruthlessly exploited to beathe life into a corpse….” This is an opinion that we do not agree ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-746c

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9

Digitale Medien

Understanding planet Academia (1998)

Loew, Franklin M.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 869-869

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—In his thoughtful review of Donald Kennedy's book Academic Duty (Nature Med. 4, 241–2, 1998), Michael Zigmond expresses the wish that “Kennedy had devoted more space to a discussion of why there is a relative lack of attention to duty on the part of the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-869a

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10

Digitale Medien

Reply to “Understanding planet Academia” (1998)

Zigmond, Michael J.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 869-869

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Zigmond replies—I found much to praise in my review of Kennedy's book, including the central premise—that faculty should devote more attention to the academic duty that accompanies their academic freedom. However, I also noted that Kennedy ignored many of the bases of the conditions he ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-869b

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11

Digitale Medien

Idiotype vaccines in the clinic (1998)

Foon, Kenneth A. ; Bhattarcharya-Chatterjee, Malaya

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 870-870

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—In an excellent News & Views article in the June issue1, Constantin Bona comments on two papers2,3 reporting promising results of idiotype vaccine experiments in mice. Bona suggests that anti-idiotype antibodies have not been adopted as cancer vaccines in humans and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-870a

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12

Digitale Medien

IOM says NIH budget process needs more public input (1998)

Birmingham, Karen ; Ault, Alicia

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 872-872

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] After almost ten months of study, a 19-member panel has concluded that the National Institutes of Health (NIH) should seek more participation from patient advocacy groups and the general public to help set research priorities (Nature Med. 4; 375, 1998). The panel, chaired by Leon Rosenberg of the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-872a

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13

Digitale Medien

Polio eradication enters home stretch (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 873-873

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The World Health Organization (WHO) announced last month that it will ask national authorities in its 191 member states to take an inventory of laboratories which are storing wMd'type or genetically engineered polioviruses by January 1999. Laboratories housing samples will be asked to establish a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-873b

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14

Digitale Medien

US FDA to issue new rules on xenotransplantation (1998)

Novak, Kristine

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 876-876

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The US Food and Drug Administration (FDA) has announced that it will publish new guidelines on xenotransplantation this fall in the Federal Register. They will advocate long-term monitoring of organ recipients and may prohibit the use of non-human primates as organ donors. The FDA will also ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-876a

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15

Digitale Medien

Mapping the biomedical research landscape (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 877-877

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Based on an evaluation of 215,000 scientific papers published between 1988–95, the UK is maintaining its share of the world's biomedical research publications at ten percent. This data comes from a report produced by the Wellcome Trust—Mapping the Landscape—which also shows that ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-877b

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16

Digitale Medien

Lessons from an age-old war (1998)

Powis, Stephen H.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 887-888

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] DELVE INTO ANY textbook of immunology and marvel at the intricacies of the immune response. Then pay a visit to your friendly neighborhood transplant clinic and despair at the crude drugs used to suppress this complex system. The truth is that when it comes to designing ways to manipulate the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-887

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17

Digitale Medien

In vivo cellular optical coherence tomography imaging (1998)

Boppart, Stephan A. ; Bouma, Brett E. ; Pitris, Costas ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 861-865

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Neoplasias are most responsive to medical intervention at early stages, prior to undergoing metastasis. When these disorders arise from known premalignant states, and if a detection method exists, the high-risk population can be screened to reduce patient morbidity and mortality. Organs where these ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-861

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18

Digitale Medien

Reply to : A role for IL-15 in rheumatoid arthritis? (1998)

Mcinnes, Iain B. ; Leung, Bernard P. ; Feng, Gui-Jie ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 643-643

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] McInnes etal. reply—Shah etal. suggest that measurement of interleukin-15 (IL-15) levels in synovial fluid may be complicated by the presence of rheumatoid factor (RF) (although we note that the level of IL-15 recovered from ‘spiked’ SF in their assay was reduced in the presence ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-643b

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19

Digitale Medien

DNA immunization protects nonhuman primates against rabies virus (1998)

Lodmell, Donald L. ; Ray, Nancy B. ; Parnell, Michael J. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 949-952

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] More than 40,000 people die annually from rabies worldwide1. Most of these fatalities occur in developing countries, where rabies is endemic, public health resources are inadequate and there is limited access to preventive treatment2. Because of the high cost of vaccines derived from cell culture, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-949

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20

Digitale Medien

Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease (1998)

Palfi, Stéphane ; Condé, Françoise ; Riche, Danielle ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 963-966

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Substitutive therapy using fetal striatal grafts in animal models of Huntington disease (HD) have already demonstrated obvious beneficial effects on motor indices1. Using a new phenotypic model of HD recently designed in primates2,3, we demonstrate here complete and persistent recovery in a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-963

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21

Digitale Medien

On the market (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 978-980

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] NEUROCHEMICALS Four new opioid receptor agonists have been added to RBI's line of opioid products for neuroscience research. For example, BW373U86 hydrochloride is a novel potent, nonpeptide δ-opioid receptor agonist. Endomorphin-1 and endomorphin-2, on the other hand, are potent and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-978

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22

Digitale Medien

Vaccine reactions (1998)

Mascola, John R. ; McNeil, John G. ; Brix, Deborah L.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 746-746

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—In your recent Vaccine Supplement, Burton and Moore discuss HIV vaccine development1. It is unfortunate that when discussing how best to proceed toward a vaccine, the debate is too often couched in the oversimplified terminology of empiric vaccine testing versus further basic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-746a

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23

Digitale Medien

Overexpression of E2F‐1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo (1998)

Fueyo, J. ; Gomez-Manzano, C. ; Yung, W.K.A. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 685-690

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The transfer of apoptosis genes to tumors is one of the most promising strategies for cancer gene therapy. We have shown that massive apoptosis occurs when wild-type p53 expression is induced in glioma cells carrying a p53 gene mutation. However, adenovirus-mediated p53 gene transfer is ineffective ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-685

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24

Digitale Medien

Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2 (1998)

Kato, Masato ; Wang, Huiming ; Kainulainen, Varpu ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 691-697

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The activity of fibroblast growth factor 2 (FGF-2) is stringently controlled. Inactive in undisturbed tissues, it is activated during injury and is critical for tissue repair. We find that this control can be imposed by the soluble syndecan-1 ectodomain, a heparan sulfate proteoglycan shed from ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-691

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25

Digitale Medien

Idiotypic immunization induces immunity to mutated p53 and tumor rejection (1998)

Ruiz, Pedro J. ; Wolkowicz, Roland ; Waisman, Ari ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 710-712

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The p53 molecule might serve as a common tumor-associated antigen, as the tumor suppressor gene p53 is mutated and the p53 protein is often over-expressed in tumor cells. We report that effective immunity to p53 can be induced through an idiotypic network by immunization of mice with a monoclonal ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-710

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26

Digitale Medien

Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor (1998)

Pedrazzini, Thierry ; Seydoux, Josiane ; Künstner, Pierre ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 722-726

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Neuropeptide Y (NPY) is a 36-amino-acid neurotransmitter which is widely distributed throughout the central and peripheral nervous system1. NPY involvement has been suggested in various physiological responses including cardiovascular homeostasis2 and the hypothalamic control of food intake3. At ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-722

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27

Digitale Medien

The Alarming History of Medicine (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 735-735

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] AMUSING ANECDOTES FROM HIPPOCRATES TO HEART TRANSPLANTS By Richard Cordon St. Martin's Griffin, $12.95, 256 pp. ISBN 0-312-16763-6, 1997 REVIEWED BY PAUL R. MCHUGH Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine Baltimore, Maryland 21287 Richard ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-735a

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28

Digitale Medien

Six decades of vaccine development—a personal history (1998)

Hilleman, Maurice R.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 507-514

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Historical beginnings The sciences of vaccines and immunology1 were created by Jenner in 17962 in his demonstration of the scientific principles and realities for preventing smallpox by prior infection with the related but less virulent cowpox virus2. Jenner's findings lay fallow for more than a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-507

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29

Digitale Medien

Cancer vaccines (1998)

Pardoll, Drew M.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 525-531

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Drew Pardoll (Johns Hopkins Oncology Center) examines prospects for therapeutic cancer vaccines. Considering how it is that the immune system fails to recognize and destroy cancer cells, Pardoll discusses contemporary vaccine approaches aimed at exposing cancer antigens to the cellular arm of the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-525

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30

Digitale Medien

Genetic effects on HIV disease progression (1998)

Ioannidis, John P. A. ; O'Brien, Thomas R. ; Rosenberg, Philip S. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 536-536

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The controversy surrounding the effect of specific chemokine receptor polymorphisms on HIV disease progression1,2 highlights the need for synthesis of the pertinent evidence. It also suggests that large-scale international collaborations3,4 are indispensable when it comes to addressing important ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-536

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Reply to “HHV-6 and multiple sclerosis” (1998)

Jacobson, Steven ; Soldan, Samantha S. ; Berti, Rossana

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 538-538

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Soldan et al. reply—We agree with Fillet et al. that serological studies in MS are difficult to interpret due to defects in immunoregulation which often result in increased antibody titers in MS patients. However we demonstrated that the IgG and IgM antibody responses of MS patients to two ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-538

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Australian government renews CRC contribution (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 540-540

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Australian government has voted to continue funding the Cooperative Research Centre (CRC) program, which is dedicated to encouraging industries and academic research organizations to work together. The decision has been awaited since a review of the program in the second half of 1997, led by ...

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URL: http://dx.doi.org/10.1038/nm0598-540b

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Crickets join Neurolab (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 542-542

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] 1,500 crickets, some still in the egg stage, have joined the mice, rats, snails and fish aboard Neurolab—the Columbia space shuttle flight dedicated to neuroscience research, which blasted off from Cape Canaveral on April 17th. Crickets are used as a model of central nervous system (CNS) ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-542b

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Digitale Medien

Hypocretins or hyporexins? (1998)

Nisoli, Enzo ; Carruba, Michele O. ; Valerio, Alessandra ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 645-645

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—Recently Schwartz1 reviewed the importance of two new hypo-thalamic peptides, orexin A, 33 amino acids, and orexin B, 28 amino acids, in energy homeostasis. Molecular genetic studies in rodents have provided convincing evidence supporting relevant roles for several hypothalamic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-645c

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…and in HIV vaccine development (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 648-649

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Within weeks of accusations by the dean of Public Health at Allegheny University, Jonathan Mann, that the National Institutes of Health (NIH) is violating human rights through its failure to test current HIV vaccine candidates in Phase III trials (Nature, 392; 527 1998), 75 of America's leading ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-648b

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Digitale Medien

A tale of two cancer drugs (1998)

Cimons, Marlene

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 650-650

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] It seemed too good to be true. And, ultimately, it was. For a few chaotic days, a story prominently displayed on the front page of the normally restrained New York Times prompted a public frenzy among cancer patients, researchers and the media. The piece, written by Gina Kolata, one of the paper's ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-650b

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The science of art and vice versa (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 652-652

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In an effort to ‘stimulate and capture the public's imagination,’ the world's largest medical research charity, the Wellcome Trust, is spending £80,000 ($125,000) on an initiative that brings artists and scientists together. Now in its second year, the program funds ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-652

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The next frontier of molecular medicine: Delivery of therapeutics (1998)

Jain, Rakesh K.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 655-657

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] For any therapy to be successful, it must satisfy two requirements: it must be effective in the in vivo microenvironment and it must reach target cells in vivo in optimal quantities1. Extraordinary advances in molecular biology and biotechnology have helped to identify novel targets and develop a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-655

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Calcineurin—the missing link in cardiac hypertrophy (1998)

Izumo, Seigo ; Aoki, Hiroki

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 661-662

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] NOT TOO LONG ago, a renowned cardiologist asked a colleague, a respected immunologist, whether there was any link between the heart and lymphocytes. The best answer they could come up with was that the heart pumps lymphocytes around the body. To the same question, a heart surgeon said that ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-661

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Idiotype vaccines: Forgotten but not gone (1998)

Bona, Constantin A.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 668-669

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] IDIOTYPES ARE ANTIGENIC determinants and phenotypic markers of V-region genes that encode the specificity of antibodies (and T-cell receptors)1. The diversity of antigen receptors on lymphocytes is reflected in the diversity of idiotypes. This means that statistically the antigen dictionary of both ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-668

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Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking (1998)

Block, Timothy M. ; Lu, Xuanyong ; Mehta, Anand S. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 610-614

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A novel strategy for anti-viral intervention of hepatitis B virus (HBV) through the disruption of the proper folding1 and transport2 of the hepadnavirus glycoproteins is described. Laboratory reared woodchucks chronically infected with woodchuck hepatitis virus (WHV) were treated with ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-610

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Detection of tumor angiogenesis in vivo by α v β 3 -targeted magnetic resonance imaging (1998)

Sipkins, Dorothy A. ; Cheresh, David A. ; Kazemi, Mahmood R. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 623-626

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Angiogenesis, the formation of new blood vessels, is a requirement for malignant tumor growth and metastasis1–3. In the absence of angiogenesis, local tumor expansion is suppressed at a few millimeters and cells lack routes for distant hematogenous spread. Clinical studies have demonstrated ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-623

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Functional integration of striatal allografts in a primate model of Huntington's disease (1998)

Kendall, A. Lisa ; Rayment, F. David ; Torres, Eduardo M. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 727-729

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Huntington's disease is an autosomal dominant, inherited disorder that results in progressive degeneration of the basal ganglia (especially the neostriatal caudate nucleus and putamen) and other forebrain structures and is associated with a clinical profile of movement, cognitive and psychiatric ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-727

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On the market (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 742-744

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] ES CELL STUDIES Day 12 hematopoietic embryoid bodies. StemCell Technologies has recently launched a line of products under the ES-Cult name for the in vitro maintenance and hematopoietic differentiation of mouse embryonic stem (ES) cells. Two-step in vitro differentiation of ES cells in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-742

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Living up to the legacy (1998)

Nossal, Sir Gustav

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 475-476

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] At millennium's end, vaccinology presents some startling contrasts. On the one hand, the expanded program on immunization represents one of the great public health triumphs of all time. Poliomyelitis is on the pathway to eradication, measles transmission has ceased in many countries, BCG and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-475

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Deal emphasizes the importance of DNA vaccines (1998)

Watanabe, Myrna E.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 478-478

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] There is perhaps no better single illustration of the commerical importance of vaccines as medicines for the next century than thedeal signed between the two British companies, Powderject Pharmaceuticals and Glaxo Wellcome (GW). With a potential total value of around $300 million, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-478a

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Vaccine visions and their global impact (1998)

Bloom, Barry R. ; Widdus, Roy

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 480-484

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Shortly after the assassination of Prime Minister Indira Gandhi in 1984, Jim Grant, Administrator of UNICEF and Hafdan Mahler, Director-General of World Health Organization (WHO), flew to New Delhi on an extraordinary mission. They proposed to her surviving son, Rajiv, that instead of building a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-480

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Digitale Medien

Slaying the Hydra all at once or head by head? (1998)

Sansonetti, Philippe J.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 499-500

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] DIARRHEAL DISEASES ACCOUNT for three million deaths annually, mostly among children1. Overcrowded suburbs in expanding Third World cities, poor rural dwellings and refugee camps are sites where the lack of hygiene makes diarrhea an overwhelming public health problem. Furthermore, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-499

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Alchemy for asthma (1998)

Cookson, William O.C.M. ; Moffatt, Miriam F.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 500-501

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] ASTHMA is A modern plague, affecting more than ten percent of children in many westernized societies. The prevalence of asthma and other allergic diseases has doubled in the last twenty years. Although much is known about the ubiquitous environmental antigens (known as allergens) that precipitate ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-500

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Vaccine production in russia : An update (1998)

Westerdahl, Kristina S. ; Roffey, Roger

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 506-506

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The fall of the Soviet Union brought independence, democracy, and the promise of a new and brighter future to the Russian people. But it also heralded a renewed threat from infectious diseases. In the decade since the fall, Russia has experienced a dramatic increase in diphtheria, measles and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-506

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A minimal glycine-alanine repeat prevents the interaction of ubiquitinated IκBα with the proteasome: a new mechanism for selective inhibition of proteolysis (1998)

Sharipo, Anatoly ; Imreh, Marta ; Leonchiks, Ainars ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 939-944

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Epstein-Barr virus nuclear antigen 1 contains a glycine-alanine repeat that inhibits in cis MHC class l-restricted presentation. We report here that insertion of a minimal glycine-alanine repeat motif in different positions of IκBα protects this NF-κB inhibitor from ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-939

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Fields of Pharmaceuticals (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 535-535

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Two papers in this issue demand the attention of all those interested in developing plant-based Pharmaceuticals and vaccines and other therapies to fight infectious diseases. The first demonstrates the successful use of a plant-derived secretory antibody to prevent bacterial infection and the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-535

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Retroviral zoonoses (1998)

Weiss, Robin A.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 391-392

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] CROSS-SPECIES INFECTION has become a hot topic again. The link between new variant Creutzfeld-Jakob disease (nvCJD) and bovine spongiform en-cephalopathy, the Sin Nombre han-tavirus outbreak in the US Southwest, concerns about virus transmission via xenotransplantation, and the recent deaths in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-391

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Monster plaques: What they tell us about Alzheimer's disease (1998)

Yankner, Bruce A.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 394-395

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] THE PRESENIUN GENES (PS) are the most common cause of early-onset familial Alzheimer's disease (AD). Until recently the only difference between the clinical syndrome associated with presenilin mutations and classic AD was an earlier age of onset12. However, four families have now been ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-394

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Identification of a human population infected with simian foamy viruses (1998)

Heneine, Walid ; Switzer, William M. ; Sandstrom, Paul ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 403-407

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Studying the transmission of simian retroviruses to humans can help define the importance of these infections to public health. We identified a substantial prevalence (4/231, 1.8%) of infection with simian foamy viruses (SFV) among humans occupationally exposed to nonhuman primates. Evidence ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-403

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Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination (1998)

Cheynier, Rémi ; Gratton, Sophie ; Halloran, Matilda ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 421-427

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCC inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-421

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Deregulation of cell growth by the K1 gene of Karposi's sarcoma-associated herpesvirus (1998)

Lee, Heuiran ; Veazey, Ronald ; Williams, Kenneth ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 435-440

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] At a position equivalent to the gene encoding the saimiri transforming protein (STP) of herpesvirus saimiri (HVS), Kaposi's sarcoma-associated herpesvirus (KSHV) contains a distinct open reading frame called K1. Although KSHV and HVS are related members of the rhadinovirus subgroup of gamma ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-435

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Closer to neurogenesis in adult humans (1998)

Kempermann, Gerd ; Gage, Fred H.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 555-557

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A RECENT PAPER by Gould and colleagues describes for the first time the generation of new nerve cells in the brains of adult marmoset monkeys (more specifically in the hippocampal formation of the temporal lobe)1. This finding can be added to a growing list of reports2–5 that together render ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-555

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Malaria: In the belly of the beast (1998)

Richman, Adam M. ; Kafatos, Fotis C.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 552-553

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] ONE OF THE most exciting aspects of contemporary biomedical research is the application of new tools to the study of organisms that for various reasons have not been considered amenable to experimental analysis. An example is the mosquito vector of malaria, which is arguably the most important ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-552

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Reorganizing the brain (1998)

Pons, Tim P.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 561-562

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] ALTHOUGH DAMAGE TO the human brain or spinal cord is generally regarded as irreversible from a neurological perspective, it is well recognized that physical rehabilitation after neurological injury aids recovery of behavioral function. It is only during the last 20 years that it has become widely ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-561

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The cyclin-dependent kinase inhibitor p27 Kip1 safeguards against inflammatory injury (1998)

Ophascharoensuk, Vuddhidej ; Fero, Matthew L. ; Hughes, Jeremy ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 575-580

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The cyclin-dependent kinase inhibitor p27Kip1 controls cell proliferation in response to normal mitogenic stimuli. We show here that p27Kip1 also safeguards against excessive cell proliferation in specific pathophysioiogic settings. We used experimental glomerulonephritis as a paradigm for immune ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-575

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Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats (1998)

Zawada, W. Michael ; Cibelli, Jose B. ; Choi, Paul K. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 569-574

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor tissue is limited and variable, an alternative and genetically modifiable non-human source of tissue would be valuable. We have generated ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-569

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Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression (1998)

Melcher, Alan ; Todryk, Stephen ; Hardwick, Nicola ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 581-587

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In situ killing of tumor cells using suicide gene transfer to generate death by a non-apoptotic pathway was associated with high immunogenicity and induction of heat shock protein (hsp) expression. In contrast, a syngeneic colorectal tumor line, CMT93, killed predominantly by apoptosis, showed ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-581

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Germany funds two new bioethics programs (1998)

Peerenboom, Ellen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 261-261

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Germany was not among the 20 European countries which signed the European Convention on Human Rights and Biomedicine treaty banning human cloning this January. However, the German research-funding body, the Deutsche Forschungsge-meinschaf (DFG) and the country's science ministry, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-261a

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Detection of single amyloid β-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy (1998)

Pitschke, M. ; Prior, R. ; Haupt, M. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 832-834

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Alzheimer's disease is associated with the intraparenchymal growth of plaque-like amyloid deposits1–3. Amyloid plaques are formed by the progressive deposition and transformation of soluble amyloid β-protein monomers into insoluble and fibrillar aggregates that contain amyloid ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-832

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Tissue microarrays for high-throughput molecular profiling of tumor specimens (1998)

Kononen, Juha ; Bubendorf, Lukas ; Kallionimeni, Anne ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 844-847

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Many genes and signalling pathways controlling cell proliferation, death and differentiation, as well as genomic integrity, are involved in cancer development. New techniques, such as serial analysis of gene expression and cDNA microarrays, have enabled measurement of the expression of thousands of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-844

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Genetics, Society and Clinical Practice (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 857-858

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] By P. S. Harper & A.J. Clarke BIOS Scientific Publishers, £19.95, 264 pp. ISBN1-859962-068, 1997 REVIEWED BY ARNO G. MOTULSKY University of Washington Department of Medicine and Genetics RG-25 Seattle, WA 98195-0001 The two British authors of this book, both from the Institute of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-857b

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On the market (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 865-866

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] IT's A KNOCKOUT Three new transgenic mice deficient in Fc receptors for studying immune responses—the FcRγ knockout, FcγRII knockout and the FcRγ/FcγRII double knockout mouse models—are now available from Taconic. The FcRγ and the FcγRII are ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-865

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A role for IL-15 in rheumatoid arthritis? (1998)

Shah, Manisha H. ; Hackshaw, Kevin V. ; Caligiuri, Michael A.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 643-643

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—Mclnnes et al. have reported a potential role for interleukin-15 (IL-15) in the pathogenesis of rheumatoid arthritis (RA)U. The in vitro functional data in support of their hypothesis rest, in part, on the very high concentrations of IL-15 detected in synovial fluid of patients ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-643a

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External stenting & atherosclerosis (1998)

Tedgui, Alain ; Mallat, Ziad ; Lehoux, Stéphanie

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 645-645

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In the February issue, Mehta and colleagues1 reported that the application of an external stent to a pig saphenous vein graft reduced medial thickening, intima formation and cell proliferation associated with reduced PDGF expression. As the study was conducted on normolipidemic animaJs, no ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-645b

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Breast cancer research stamp (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 647-647

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The US Post Office has unveiled a new postage stamp to be sold in support of breast cancer research. The ‘semipostal’ stamp, which goes on sale in August, will cost 8 cents more than regular postage and the extra proceeds will go to support breast cancer research programs at the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-647b

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McVie calls for reduction in cancer charity numbers (1998)

Dickson, David

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 650-650

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Britain has too many cancer research charities, with the result that funds donated by the public for research are not being used as effectively as they could be, according to Gordon McVie, the head of one of the largest such bodies, the Cancer Research Campaign (CRC). In a speech last month that ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-650a

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Evidence for the HIV-1 phenotype switch as a causal factor in acquired immunodeficiency (1998)

Glushakova, Svetlana ; Grivel, Jean-Charles ; Fitzgerald, Wendy ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 346-349

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Both cellular and humoral immunodeficiency develop in vivo after prolonged infection with HIV-1, but the mechanisms are unclear1. Initial infection with HIV-1 is transmitted by macrophage (M)-tropic/non-syncytia-inducing (NSI) viruses2,3, which hyperactivate the immune system4,5, and, in one view, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-346

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Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria (1998)

Bull, Peter C. ; Lowe, Brett S. ; Kortok, Moses ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 358-360

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The feasibility of a malaria vaccine is supported by the fact that children in endemic areas develop naturally acquired immunity to disease. Development of disease immunity is characterized by a decrease in the frequency and severity of disease episodes over several years despite almost continuous ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-358

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Murine γ-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-γ responsiveness: A new model for virus-induced vascular disease (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 363-363

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Murine γ-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-γ responsiveness: A new model for virus-induced vascular disease K.E. WECK, A.j. DAL CANTO, j.D. GOULD, A.K. O'GUIN, K.A. ROTH, J.E. SAFFITZ, S.H. SPECK & H.W. VIRGIN Nature Med. 3, 1346-1353 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-363b

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The ticklish brain (1998)

Aamodt, Sandra

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 384-384

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Some days a good laugh is hard to find in a neurosur-geon's operating room, but Itzhak Fried and his colleagues (University of California, Los Angeles) got an entertaining surprise recently while they were mapping the brain of a 16 year-old epileptic girl {Nature 391, 650, 1998). Electrical ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-384

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Orexins and appetite: The big picture of energy homeostasis gets a little bigger (1998)

Schwartz, Michael W.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 385-386

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] DESPITE FREQUENT AND sometimes severe fluctuations in energy intake and expenditure, the amount of fuel stored in the form of adipose tissue remains remarkably stable over the adult lifetime of most mammals. Nearly fifty years ago, this observation led to the hypothesis that body adiposity is ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-385

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Two strings to the bow of Ebola virus (1998)

Klenk, Hans-Dieter ; Volchkov, Viktor E. ; Feldmann, Heinz

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 388-389

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] MARBURG AND EBOLA virus are filoviruses that cause fulminant hemorrhagic fever in humans and nonhuman primates, killing up to 90 percent of infected individuals. Since the discovery of Marburg virus in 1967 and its better known cousin, Ebola, a few years later, these pathogens have been cause for ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-388

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COX-2 inhibitors for colorectal cancer (1998)

Elder, Douglas J. E. ; Paraskeva, Christos

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 392-393

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] DESPITE PROGRESS IN our understanding of tumor biology, coiorectal cancer continues to be a major cause of death. One promising avenue for preventing this cancer is the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and sulindac. However, the use of traditional NSAIDs— ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-392

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Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara (1998)

Schneider, Jörg ; Gilbert, Sarah C. ; Blanchard, Tom J. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 397-402

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Immunization with irradiated sporozoites can protect against malaria infection and intensive efforts are aimed at reproducing this effect with subunit vaccines. A particular sequence of subunit immunization with pre-erythrocytic antigens of Plasmodium berghei, consisting of single dose priming with ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-397

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TNFα regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation (1998)

Sata, Masataka ; Walsh, Kenneth

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 415-420

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] It is generally believed that the vascular endothelium serves as an inflammatory barrier by providing a nonadherent surface to leukocytes. Here, we report that Fas ligand (FasL) is expressed on vascular endothelial cells (ECs) and that it may function to actively inhibit leukocyte extravasation. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-415

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Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease (1998)

Lunardi-Iskandar, Yanto ; Bryant, Joseph L. ; Blattner, William A. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 428-434

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The effects of clinical grade crude preparations of human chorionic gonadotropin (hCG) on Kaposi's sarcoma, HIV, SIV and hematopoiesis were examined in vitro and in vivo. In contrast to previous studies, we report that the antiviral activity of hCG associated factors is not due to the native hCC ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-428

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Local paracrine effects of estradiol are central to parturition in the rhesus monkey (1998)

Nathanielsz, Peter W. ; Jenkins, Susan L. ; Tame, Jennifer D. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 456-459

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The central biochemical mechanisms involved in primate parturition are still unclear. Studies in both humans and nonhuman primates such as the baboon and rhesus monkey indicate that many factors play a part in the cascade of interactive positive feedforward loops that progressively promote ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-456

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Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin (1998)

Jevtović-Todorović, V. ; Todorovć, S. M. ; Mennerick, S. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 460-463

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Extensive research has failed to clarify the mechanism of action of nitrous oxide (N2O, laughing gas), a widely used inhalational anesthetic and drug of abuse. Other general anesthetics are thought to act by one of two mechanisms—blockade of NMDA glutamate receptors or enhancement of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-460

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Matters of Life and Death (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 465-465

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] PERSPECTIVES ON PUBLIC HEALTH, MOLECULAR BIOLOGY, CANCER AND THE PROSPECTS FOR THE HUMAN RACE. by John Cairns Princeton university press, 258 pp. ISBN 0-691-02872-9, 1997 The University of Texas M.D. Anderson Cancer Center Houston, TX 77030 “Matters of Life and Death” is a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-465b

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On the market (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 471-472

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] DNA/RNA ANALYSIS SYSTEMS Catch the Wave DNA fragment analysis system. Transgenomic has introduced a high-resolution DNA and RNA analysis system, which uses a high-resolution chromato-graphic matrix in a fully automated, fully integrated computerized instrument. The Wave DNA fragment analysis ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-471

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Viruses and vascular disease (1998)

Yonemitsu, Yoshikazu

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 253-254

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—In the December 1997 issue, Week and colleagues suggested that murine gamma-herpesvirus (γHV) 68 can give rise to severe large-vessel ar-teritis in mice1. According to Koch's postulate, several conditions must be met before assigning a specific pathology to a given ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-253

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Is the UK ready for Jointly Managed Academic Medical Centers? (1998)

Dickson, David

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 256-256

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Pressure is growing in Britain for the creation of a new type of medical institute designed to overcome tensions between university medical schools and the National Health Service (NHS) by bringing them together into a coordinated management structure. The need for such an initiative arises from ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-256a

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Indian firm in dispute with SmithKline Beecham (1998)

Jayaraman, K.S.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 257-257

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Three months after being fined for creating an “unnecessary panic” over the rate of hepatitis-B infection in Hungary where it markets a vaccine for the disease, the UK-based pharmaceutical company, SmithKline Beecham (SB), is facing allegations of a “smear campaign” in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-257a

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90

Digitale Medien

Improving communication between scientists and the press (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 258-258

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Scientific journalism was the subject of attention on both sides of the Atlantic last month. While the British media reported non-existent rows between UK scientists and the government, a Harvard University committee published guidelines to improve science-media communication in the US. Stories ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-258a

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91

Digitale Medien

Cancelled trial exposes Japanese research deficiencies (1998)

Saegusa, Asako

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 260-260

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Green Cross Corporation, a major pharmaceutical company and leading blood products manufacturer in Japan, announced last month that it is abandoning a proposed gene therapy trial on four HIV patients at Kumamoto University Medical School. The cancellation of the trial is unsurprising to many: a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-260b

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92

Digitale Medien

Japanese infectious diseases law (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 261-261

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Japanese Council on Public Health has recommended that the government works out a comprehensive law aimed at preventing infectious diseases. The law, slated for April 1999, would cover all infectious diseases including influenza, AIDS, Ebola and hemorrhagic fever and categorize them into four ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-261b

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93

Digitale Medien

Who is Jane Henney? (1998)

Cimons, Marlene

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 262-262

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] After months of waiting, David Satcher was confirmed as Surgeon General and Assistant Secretary for Health by the US Senate on February 10th (Nature Med. 3; 1997). Without hesitation, lobbyists have turned their attentions to a position of greater power and importance in the field of public health: ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0398-262

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94

Digitale Medien

Genetics research on the town hall agenda, courtesy of ELSI (1998)

Dove, Alan

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 541-541

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] As in some other US States, the citizens of Vermont gather in town halls each Spring to hold meetings. Grievances are aired, issues debated and local laws enacted at the gatherings. However, a new program at the University of Vermont is hoping to add another item to the agenda this ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-541a

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95

Digitale Medien

Dengue fever on the increase (1998)

Dove, Alan

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 543-543

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Outbreaks of dengue fever, the most widespread vector-borne viral disease known, seem to be on the increase worldwide, causing physicians and public health officials to fret over ways to stem the pathogen's progress. While an epidemic of dengue around Rio de Janeiro continues to claim lives, a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-543b

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96

Digitale Medien

Plants are not just passive creatures! (1998)

Arakawa, Takeshi ; Langridge, William H. R.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 550-551

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] ADVANCES IN RECOMBINANT DNA technology have enabled plant molecular biologists to transfer a remarkable variety of foreign genes encoding therapeutic proteins into plant species such as potato and tobacco. Plants have been selected as bioreactors because their eukaryotic nature often permits ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-550

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97

Digitale Medien

The ‘Fantastic Voyage’ of muscle progenitor cells (1998)

Partridge, Terry

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 554-555

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] PART OF THE attraction of gene therapy is its underlying promise of ‘magic bullet’ solutions. So far, however, the efficiency and accuracy of targeting genetic bullets to the desired cells have not reached therapeutically useful proportions. The exceptions are, perhaps, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-554

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98

Digitale Medien

Two deaf mice, two deaf mice… (1998)

Heller, Stefan ; Hudspeth, A. J.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 560-561

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] You ARE ALREADY partially deaf. As a reader in a modern industrialized country (or perhaps in England), you are subjected daily to automotive, industrial, and recreational sounds that damage the inner ear's sensory receptors, or hair cells. These cells are constantly active, for their transduction ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-560

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99

Digitale Medien

Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1 /Fas) Mediated apoptosis (1998)

Strand, Susanne ; Hofmann, Walter J. ; Grambihler, Annette ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 588-593

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Wilson's disease can result in fulminant liver failure due to hepatic copper overload. The CD95 system mediates apoptosis and has been demonstrated to be involved in liver disease. In this study CD95 mediated apoptosis was investigated in patients with fulminant hepatic failure in the course of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-588

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100

Digitale Medien

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes (1998)

Zitvogel, Laurence ; Regnault, Armelle ; Lozier, Anne ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 594-600

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Dendritic cells (DCs) are professional antigen presenting cells with the unique capacity to induce primary and secondary immune responses in vivo. Here, we show that DCs secrete antigen presenting vesicles, called exosomes, which express functional Major Histocompatibility Complex class I and class ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-594

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