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  • Artikel  (26.585)
  • Springer  (15.992)
  • Wiley-Blackwell  (9.574)
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  • 1995-1999  (15.295)
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  • Artikel  (26.585)
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  • 1
    Digitale Medien
    Digitale Medien
    Old World, new development (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 504-504 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] ... Europe's engagement in and commitment to biotechnology has been the subject of significant controversy over the past 10 years. Powerful antitechnology forces have applied their influence to block biotechnology's growth in Europe, but technology seems to be the only solution to effect the ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/8688
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  • 2
    Digitale Medien
    Digitale Medien
    People (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 506-506 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Amgen (Thousand Oaks, CA) has appointed Fabrizio Bonanni senior vice president, quality and compliance. Mr. Bonanni most recently held the position of corporate vice president, regulatory/clinical affairs at Baxter International. He succeeds Daryl Hill, who retired in March after 15 years with ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/8692
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  • 3
    Digitale Medien
    Digitale Medien
    New products (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 507-507 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Filtration ... Fast filters Nalgene MF75 Series products from Nalge Nunc (Rochester, NY) are available in 75 mm diameter sizes that cut filtration time in half, compared with 50 mm diameter membranes. The 500 ml and 1 L units come with a choice of membranes, and matching receivers feature a ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/8693
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  • 4
    Digitale Medien
    Digitale Medien
    Genetically modified muddle (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 311-311 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Do you grow your own food? Do you pack it yourself? Have you had it in your possession at all times? If the answer to any of these questions is no, then you have made significant assumptions about the food you eat and the level of food security risk that is acceptable to you. Whether the ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7825
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  • 5
    Digitale Medien
    Digitale Medien
    Errata (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 314-314 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In "This Month in Nature Biotechnology" (Nat. Biotechnol. 17, 214, March 1999 ), a brief describing a research article on directed DNA evolution of thymidine kinase incorrectly stated that the viral form of the enzyme has lower substrate affinity than the human form. The viral form actually ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7831
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  • 6
    Digitale Medien
    Digitale Medien
    India faces GM cotton delay (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 315-315 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] India's first biotechnology-related court case could delay introduction of Monsanto's (St. Louis, MO) genetically modified (GM) Bollgard cotton by a year. The Research Foundation for Science, Technology and Ecology, a nongovernmental organization in Delhi, has filed a petition alleging that ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7833
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  • 7
    Digitale Medien
    Digitale Medien
    Food fight in Colombia (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 315-315 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The United States, Canada, Australia, and several South American agriculture export nations formed a small but potent coalition that deliberately lodged a spanner in the Biosafety Protocol negotiations, held in Cartagena, Colombia, during February (Nat. Biotechnol. 17, 123, 1999). The ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7836
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  • 8
    Digitale Medien
    Digitale Medien
    Research collaborations (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 316-316 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7843
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  • 9
    Digitale Medien
    Digitale Medien
    Swiss ban xenotransplants (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 316-316 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The Swiss Federal Council (Bundesrat) ruled in March to ban xenotransplantation from animals to humans, except in clinical research. The move is intended to appease green lobbyists, who have been calling for a moratorium. However, the partial ban permits what is technically not yet possible, ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7842
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  • 10
    Digitale Medien
    Digitale Medien
    Adenovirus vector gutted (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 317-317 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Because it infects virtually all cell types, can carry large DNA insertions, and is easy to produce in quantity, adenovirus has been viewed as a promising gene therapy vector. One of the system's major flaws, however, is the vigorous immune response generated against adenovirus-infected cells. ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7845
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  • 11
    Digitale Medien
    Digitale Medien
    Getting the bugs out (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 318-318 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Escherichia coli has been an indispensable system for cloning recombinant DNA molecules to study gene function and regulation. This workhorse of the molecular laboratory could soon be put out to pasture, however. In this issue, Sykes and Johnston report that PCR products encoding promoters, ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7865
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  • 12
    Digitale Medien
    Digitale Medien
    European Parliament considers release of GMOs (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 321-321 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The European Parliament (Strasbourg) has adopted a mixed bag of new amendments to directive 90/220/EEC, which is the framework for the safe environmental release and marketing of genetically modified organisms (GMOs). The amendments stand both to nurture and further constrain the GMO product ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7870
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  • 13
    Digitale Medien
    Digitale Medien
    Producing collagen in a mammary bioreactor (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 318-318 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Because of its unusual tensility, collagen has made its way into products as diverse as desserts, shampoo, and bioengineered skin. Usually collagen is extracted from cow hooves and hide, but for medical applications, sources other than rendering lots are needed to ensure the supply is highly ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7864
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  • 14
    Digitale Medien
    Digitale Medien
    Japan pushes to capitalize on biotechnology (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 320-321 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The Japanese Government has introduced a new program aimed at launching 1,000 new biotechnology-related companies and creating 70,000–80,000 new jobs in the industry within the next decade. Although full details won't be released until June, the announcement marks a significant shift in ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7868
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  • 15
    Digitale Medien
    Digitale Medien
    Adjusting FDA policies to address bioterrorist threat (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 323-324 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] US President Clinton and top federal officials have designated bioterrorism preparedness a major priority. In doing so, they plan to stockpile certain vaccines and antimicrobial drugs—a step that very much depends on improving and, in some cases, replacing specific components that are to ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7873
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  • 16
    Digitale Medien
    Digitale Medien
    Knocking out the herpesvirus genome (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 318-318 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Although the herpesvirus genome has been completely sequenced, the roles of many gene products remain unknown. Unlocking these secrets demands strategies to mutate individual genes and see how this affects viral life cycle. To make this easier, Brune et al. have developed a rapid mutagenesis ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7858
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  • 17
    Digitale Medien
    Digitale Medien
    A single adenovirus vector mediates doxycycline-controlled expression of tyrosine hydroxylase in brain grafts of human neural progenitors (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 349-354 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Ex vivo gene transfer is emerging as a promising therapeutic approach to human neurodegenerative diseases. By combining efficient methodologies for cell amplification and gene delivery, large numbers of cells can be generated with the capacity to synthesize therapeutic molecules. These cells can ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7901
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  • 18
    Digitale Medien
    Digitale Medien
    Chiral discrimination using an immunosensor (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 371-374 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Based on the stereoselectivity of immunoglobulins, we have developed a new chiral sensor for the detection of low-molecular-weight analytes. Using surface plasmon resonance detection, enantiomers of free, underivatized α-amino acids can be monitored in a competitive assay by their ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7927
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  • 19
    Digitale Medien
    Digitale Medien
    Complaints raised over restricted microarray access (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 325-326 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Some research biologists are complaining, among themselves and to federal officials, that access to microarray analysis is being unfairly restricted—thereby limiting their ability to learn more about how genes and chromosomes work. Although technology improvements and more aggressive ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7876
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  • 20
    Digitale Medien
    Digitale Medien
    Transposing BACs to the future (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 332-333 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] With the list of fully sequenced genomes growing longer every day, we have clearly entered a golden era of functional genomics. The field can be loosely defined as the comprehensive analysis of how an organism's genotype relates to its phenotype. Tremendous advances in computational biology have ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7884
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  • 21
    Digitale Medien
    Digitale Medien
    Bioartificial organs transplanted from research to reality (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 335-336 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The overwhelming consensus of last year's conference, Bioartificial Organs II, in Banff*, was that cell encapsulation technologies could present significant advantages over cellular or whole-organ replacement used in conjunction with immune-modulating drugs. Cell encapsulation strategies differ ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7888
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  • 22
    Digitale Medien
    Digitale Medien
    Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 343-348 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Tumors require ongoing angiogenesis to support their growth. Inhibition of angiogenesis by production of angiostatic factors should be a viable approach for cancer gene therapy. Endostatin, a potent angiostatic factor, was expressed in mouse muscle and secreted into the bloodstream for up to 2 ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7895
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  • 23
    Digitale Medien
    Digitale Medien
    Rapid identification of essential and nonessential herpesvirus genes by direct transposon mutagenesis (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 360-364 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Herpesviruses are important pathogens in animals and humans. The large DNA genomes of several herpesviruses have been sequenced, but the function of the majority of putative genes is elusive. Determining which genes are essential for their replication is important for identifying potential ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7914
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  • 24
    Digitale Medien
    Digitale Medien
    In vivo imaging of tumors with protease-activated near-infrared fluorescent probes (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 375-378 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] We have developed a method to image tumor-associated lysosomal protease activity in a xenograft mouse model in vivo using autoquenched near-infrared fluorescence (NIRF) probes. NIRF probes were bound to a long circulating graft copolymer consisting of poly-L-lysine and methoxypolyethylene glycol ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7933
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  • 25
    Digitale Medien
    Digitale Medien
    It's the real thing (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 837-837 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] After receiving complaints from various pressure groups, the UK Advertising Standards Authorities (ASA)—whose role is to ensure that advertisement are "legal, honest and truthful"—took Monsanto to task over a series of full-page press advertisements that aimed to communicate ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12791
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  • 26
    Digitale Medien
    Digitale Medien
    Japan to label GMOs (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 837-837 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Japan is to introduce new regulations that stipulate mandatory labeling of 30 food products containing genetically modified organisms (GMOs), including soybeans, potatoes, and corn. According to the draft regulations, unveiled in August by the Ministry of Agriculture, Forestry and Fisheries ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12792
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  • 27
    Digitale Medien
    Digitale Medien
    Genentech's 2nd IPO (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 838-838 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Genentech raised nearly $2 billion during its second initial public offering (IPO) on July 20 when Roche Holding refloated part of the company after acquiring all outstanding shares in June (Nature Biotechnology 17, 634, 1999). Twenty million shares were sold at $97 per share, raising nearly ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12793
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  • 28
    Digitale Medien
    Digitale Medien
    CT turns focus to StemCell (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 838-838 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] CytoTherapeutics (Lincoln, RI) has cut its work force by about 75% (60 employees) to concentrate on its subsidiary, StemCell (Freemont, CA). The move follows disappointing trial results of its encapsulated cell implant for pain, and subsequent withdrawal of partner AstraZeneca (London). Since ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12794
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  • 29
    Digitale Medien
    Digitale Medien
    Success from a virtual structure (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 37-38 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A virtual organization coordinating the resources of 170 companies and research institutes is providing a dramatic push forward for German ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/9110
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  • 30
    Digitale Medien
    Digitale Medien
    Killer potatoes: Where's the data? (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 207-207 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] What are we to make of the firestorm surrounding Arpad Pusztai's transgenic potato research? The storm—only one of many biotechnology conflagrations now raging across Europe—is all the more remarkable because the work at the center of the controversy has never been published or ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6906
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  • 31
    Digitale Medien
    Digitale Medien
    Antitumor vaccines with punch (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 214-214 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] ... In the quest for cancer immunotherapies, tumor-specific antigens are often regarded as tumors' Achilles' heels, in that they can potentially induce an immune cytotoxic response against tumor cells. Idiotypes on the Ig receptor of clonal B-cell malignancies are candidates for such ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6934
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  • 32
    Digitale Medien
    Digitale Medien
    Venture capital with a European twist (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 23-24 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Cultural factors suggest that European venture capitalists will follow a different model than their US counterparts in selecting companies to ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/9098
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  • 33
    Digitale Medien
    Digitale Medien
    Inside a fund manager's mind (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 29-30 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A life sciences fund manager reveals his decision-making process for investing in biotech ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/9102
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  • 34
    Digitale Medien
    Digitale Medien
    Not enough biotechs, and what government can do about it (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 35-36 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] While financial markets may believe there are too many biotechnology companies in the world, research suggests that the opposite is ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/9108
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  • 35
    Digitale Medien
    Digitale Medien
    Extending genetic vaccines with chemokines (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 226-227 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A longstanding problem in cancer vaccine research has been the poor immunogenicity of "self" tumor antigens. As a result, protein-based cancer vaccines often have proved ineffective at inducing antitumor responses, possibly because of their inability to stimulate autoreactive T cells subject to ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6964
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  • 36
    Digitale Medien
    Digitale Medien
    Proteomics: translating genomics into products? (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 233-236 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] By cataloging the entire protein content of a cell, proteomics should not only provide insight into the molecular basis of life, but also accelerate the identification of molecular targets for use in diagnostics and therapeutics. Questions remain, however, as to the capacity of current ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6972
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  • 37
    Digitale Medien
    Digitale Medien
    Silence is golden (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 840-840 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Ectopic expression of a therapeutic gene can potentially lead to deleterious side effects. On page 865, Mallet and colleagues propose that neuron-restrictive silencer elements (NRESs) may offer advantages over neuron-specific promoters for controlling the expression of such genes in neurons. ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12808
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  • 38
    Digitale Medien
    Digitale Medien
    One-step radiolabeling of scFvs (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 840-840 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Radiolabeled single-chain antibody fragments (scFvs) are potentially valuable reagents for imaging and therapeutics. However conventional techniques for binding them to radioisotopes are cumbersome and often reduce their biological activities. On page 897, Plückthun and colleagues describe ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12807
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  • 39
    Digitale Medien
    Digitale Medien
    Rationalizing a random approach (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 840-840 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Inteins are proteins that possess both endonuclease and self-splicing activity, allowing self excision and insertion at both the level of the gene and of the protein. Wood and coworkers (p. 889) have used a combination of rational design and an elegant genetic screen in Escherichia coli to ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12810
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  • 40
    Digitale Medien
    Digitale Medien
    Breeding molecules (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 840-840 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] DNA family shuffling is now well established as a powerful technique to tap into and exploit the molecular diversity of gene families. In this issue, Ness and colleagues (p. 893) use this approach to create a library of chimeric subtilisin proteases. Shuffled clones were identified that were ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12811
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  • 41
    Digitale Medien
    Digitale Medien
    Web PCR (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 304-304 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Every year scientists introduce new polymerase chain reaction (PCR) modifications: multiplex PCR, hemi-nested PCR, anchor-ligated PCR, etc. In this spirit, I now introduce—Web PCR. Unlike other PCR modifications that involve experimental protocols, Web PCR is about making the first steps ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7063
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  • 42
    Digitale Medien
    Digitale Medien
    People (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 305-305 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Oread (Lawrence, KS) has named its chief operating officer Jack L. Armstrong president, replacing David Kimbrell, the former president, CEO, and chairman of the board of directors. Additionally, Daniel Azarnoff has been appointed chairman of the board. Mr. Kimbrell will continue to serve as a ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7065
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  • 43
    Digitale Medien
    Digitale Medien
    North-South innovation transfer (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17.1999, 2s, BV11-, (2 S.) 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The 7.7 billion people living on this planet in 2020—3.5 billions living in urban areas—will only be fed if we can raise the production of food substantially. Cereal production needs to increase 41%, meat by 63%, and roots and tubers by 40%. Eighty percent of additional food will ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7153
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  • 44
    Digitale Medien
    Digitale Medien
    Business and the environment (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17.1999, 2s, BV25-, (1 S.) 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] "Green investing isn't just for greens anymore. Now an increasing number of investment professionals view ecological efficiency as a vital criterion for judging the quality of a company." So said the Wall Street Journal Europe on August 14, 1996. In a similar vein, the International Herald ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7167
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  • 45
    Digitale Medien
    Digitale Medien
    Plastid microinjection (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 840-840 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Microinjection of DNA, proteins, or small organic molecules can damage and even kill recipient cells. To address this, Knoblauch and colleagues (p. 906) have developed a device that delivers femto- to attoliter-sized samples into prokaryotes and eukaryotic organelles while maintaining cell ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12816
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  • 46
    Digitale Medien
    Digitale Medien
    Markers outgrow antibiotic resistance (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 840-840 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Virtually all genetically engineered crops contain antibiotic resistance genes. This has raised concerns that these genes could be transferred from plants to microbes, with dire consequences to human health. Although the jury is still out on the risks of such horizontal gene transfer (see 832 ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12815
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  • 47
    Digitale Medien
    Digitale Medien
    Imaging antigens by force (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 840-840 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Atomic force microscopy (AFM) is a potentially powerful tool for probing the structure of biological molecules. In this issue ( p. 902), Hinterdorfer and colleagues have come up with a new way of imaging antigenic sites on a surface, using an AFM tip with an antibody attached by a flexible ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12817
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  • 48
    Digitale Medien
    Digitale Medien
    UH researcher files transgenesis suit (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 841-841 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A researcher from the laboratory responsible for the first mouse-cloning experiments (Nature, 394, 369, 1998) is suing the University of Hawaii (UH) on the grounds that it licensed without his consent the rights to a series of technologies that he developed and claims he owns. In late July, Anthony ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12821
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  • 49
    Digitale Medien
    Digitale Medien
    Director bids aloha, storm brews over UH NSF institute (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 841-842 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The transgenesis dispute comes at a time when the University of Hawaii's (UH) practices are already in question. As the Marine Bioproducts Engineering Center (MarBEC) prepares for its first annual review by the National Science Foundation (NSF) at the end of this month, the recent departure of ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12822
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  • 50
    Digitale Medien
    Digitale Medien
    ArQule-Pfizer deal breaks mold (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 843-844 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In July, in what represents a strategic departure for ArQule (Medford, MA), the combinatorial chemistry specialist struck a technology transfer deal with Pfizer (Groton, CT) worth $117 million. ArQule will not only produce a microarray library exclusively for Pfizer but will also will transfer the ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12825
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  • 51
    Digitale Medien
    Digitale Medien
    Johnson & Johnson acquires Centocor (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 844-845 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In mid-July, Johnson & Johnson (J&J; New Brunswick, NJ) announced that it will use $4.9 million in stock to acquire one of the biopharmaceutical sector's longest lived companies, Centocor (Malvern, PA). The market liked the deal so much that both companies' stock prices rose upon the ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12826
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  • 52
    Digitale Medien
    Digitale Medien
    Europe edges closer to GMO patent harmonization (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 842-843 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] From September 1, the European Patent Office (EPO; Munich) will, in theory at least, be able to grant patents covering genetically modified plant and animal varieties. On that date, a new regulation within the European Patent Convention (EPC) comes into effect, removing an awkward discrepancy ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12824
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  • 53
    Digitale Medien
    Digitale Medien
    World Bank task force push/pulls AIDS vaccines (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 846-847 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In an effort to increase corporate interest in developing vaccines for AIDS prevention in developing countries, a task force at the World Bank (Washington, DC) is evaluating a variety of market "interventions" that would help ensure the profitability of an effective vaccine. Whereas the bank has ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12828
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  • 54
    Digitale Medien
    Digitale Medien
    Companies chase money in and out of the Eurozone (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 125-126 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The introduction of the euro (€) should financially benefit those biotechnology companies listed on exchanges trading in the new currency, according to analysts and investors. The new European currency came into use across 11 countries in Europe (Eurozone) at the start of 1999. The greater ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6120
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  • 55
    Digitale Medien
    Digitale Medien
    RASSLing with receptors (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 131-132 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The human genome is thought to encode over a thousand G–protein coupled receptors (GPCRs). One of the more daunting tasks in the postgenomic era will be defining true physiological roles for these molecules and the pathways they initiate. Approaches that allow a specific receptor to be ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6128
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  • 56
    Digitale Medien
    Digitale Medien
    Will investors return to biotechnology? (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 128-128 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Venture capital fundraising maintains record levels, according to Daniel Case, chair and CEO of Hambrecht & Quist, at the 17th Annual Healthcare Conference last month. But with over 50% of US biotechnology companies operating with only two years cash or less, why isn't this funding going to ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6126
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  • 57
    Digitale Medien
    Digitale Medien
    De novo reconstitution of a functional mammalian urinary bladder by tissue engineering (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 149-155 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Human organ replacement is limited by a donor shortage, problems with tissue compatibility, and rejection. Creation of an organ with autologous tissue would be advantageous. In this study, transplantable urinary bladder neo–organs were reproducibly created in vitro from urothelial and ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6146
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  • 58
    Digitale Medien
    Digitale Medien
    Conditional expression and signaling of a specifically designed G i -coupled receptor in transgenic mice (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 165-169 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To control G protein signaling in vivo, we have modified G protein–coupled receptors to respond exclusively to synthetic small molecule agonists and not to their natural agonist(s). These engineered receptors are designated RASSLs (receptor activated solely by a synthetic ligand). A ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6165
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  • 59
    Digitale Medien
    Digitale Medien
    Oxidative refolding chromatography: folding of the scorpion toxin Cn5 (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 187-191 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] We have made an immobilized and reusable molecular chaperone system for oxidative refolding chromatography. Its three components—GroEL minichaperone (191–345), which can prevent protein aggregation; DsbA, which catalyzes the shuffling and oxidative formation of disulfide bonds; and ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6192
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  • 60
    Digitale Medien
    Digitale Medien
    Detection and sizing of telomeric repeat DNA in situ (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 200-201 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A performance comparison of PRINS and PNA ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6209
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  • 61
    Digitale Medien
    Digitale Medien
    Xenotransplantation (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 205-206 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] There are more than five times as many people on the waiting list for organ transplants as will actually receive one. Although the number of transplants has increased by about 30% during the 1990s, the number of candidates has doubled. This acute shortage of human organs has prompted significant ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6222
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  • 62
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    Digitale Medien
    A synthetic mimic of a discontinuous binding site on interleukin-10 (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 271-275 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] We synthetically reconstructed a discontinuous binding site on interleukin-10 (IL-10) that recognizes the neutralizing anti–IL-10 antibody CB/RS/1. To design the 32-mer IL-10 mimic, a discontinuous interaction site on IL-10 was mapped, and binding studies with epitope-derived peptides led ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7018
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  • 63
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    Digitale Medien
    Ironing out plant stress (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 121-121 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Plants under stress often accumulate reactive oxygen species (ROS), which oxidize macromolecules and are toxic to cells. As ferrous iron is responsible for catalyzing the creation of many of these damaging oxygen species, why not inhibit production by mopping up the metal? In this issue, ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6293
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  • 64
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    Digitale Medien
    Low–lactose transgenic milk (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 121-121 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Hope may be on the horizon for the 70% of the adult population that finds cow's milk difficult to stomach. In these individuals, the presence of the sugar lactose leads to clinical symptoms, including abdominal pain, nausea, and diarrhea. To address this problem, dairy manufacturers offer milk ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6112
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  • 65
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    Digitale Medien
    Asthma targets: Research dilemma (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 128-129 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Two developments in identifying targets for asthma drug discovery have highlighted the precarious nature of focused drug development efforts. Last month, Magainin Pharmaceuticals (Plymouth Meeting, PA) announced a research agreement with Genentech (South San Francisco, CA) to develop asthma ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6127
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  • 66
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    Digitale Medien
    Toward designer milk (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 135-136 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] It is 12 years since the first demonstration that milk composition can be dramatically altered using gene transfer. Subsequently, several emerging transgenic technologies have focused on the mammary gland. In this issue, Bernard Jost et al. take this field one stage further, by describing the first ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6134
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  • 67
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    Digitale Medien
    Metabolic engineers in the Bavarian Alps (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 137-138 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] At the base of the Wettersteinwand in southern Bavaria, a diverse group of metabolic engineers met to discuss recent progress in the field and to compare notes on modifying biological systems*. Metabolic engineering spans the division between basic biochemical research and biotechnology ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6138
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  • 68
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    Digitale Medien
    A genetic system yields self-cleaving inteins for bioseparations (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 889-892 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A self-cleaving element for use in bioseparations has been derived from a naturally occurring, 43 kDa protein splicing element (intein) through a combination of protein engineering and random mutagenesis. A mini-intein (18 kDa) previously engineered for reduced size had compromised activity and was ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12879
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  • 69
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    Digitale Medien
    A synthetic FGF agonist (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 1150-1150 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Fibroblast growth factors (FGFs) are in clinical trials as therapies for a variety of ischemic vascular disorders. However, their short in vivo half-lives could make it difficult to maintain therapeutic levels without frequent injections. This problem has prompted Ballinger et al. to search for ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/70681
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  • 70
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    Digitale Medien
    Conserving our natural heritage (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17.1999, 2s, BV29-, (2 S.) 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] There is no doubt that in the long term, genetic modification of plants and other organisms holds the promise of being able to design crops and agricultural systems much more environmentally friendly than the chemical-based intensive agriculture we now use. For example, it is now possible to ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/7170
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  • 71
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    Digitale Medien
    Patent case unblocks antibody businesses (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 1154-1155 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] When two companies are involved in a patent dispute, there can only be one winner—except, it seems, when methods for developing improved antibodies are concerned. When the European Patent Office's (EPO; Munich, Germany) opposition division upheld Cambridge Antibody Technology's (CAT; ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/70691
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  • 72
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    Digitale Medien
    Detecting estrogens in food and the environment (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 1162-1163 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Endocrine disruptors (EDCs) are a class of either natural or synthetic compounds that are suspected of adversely affecting the health of humans, and possibly entire communities and populations of wildlife. Environmental estrogens are a particularly prevalent and potentially harmful source of ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/70703
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  • 73
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    Digitale Medien
    A galinstan expansion femtosyringe for microinjection of eukaryotic organelles and prokaryotes (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 906-909 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A galinstan expansion femtosyringe enables femtoliter to attoliter samples to be introduced into prokaryotes and subcellular compartments of eukaryotes. The method uses heat-induced expansion of galinstan (a liquid metal alloy of gallium, indium, and tin) within a glass syringe to expel samples ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12902
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  • 74
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    Digitale Medien
    Fluorescent antibiotic resistance marker for tracking plastid transformation in higher plants (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 910-915 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Plastid transformation in higher plants is accomplished through a gradual process, during which all the 300–10,000 plastid genome copies are uniformly altered. Antibiotic resistance genes incorporated in the plastid genome facilitate maintenance of transplastomes during this process. Given ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12907
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  • 75
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    Digitale Medien
    Recent patents in gene transfer (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 923-923 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12922
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  • 76
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    Digitale Medien
    New rules for natural products research (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 921-922 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Dwindling natural resources have spurred tighter regulations for biodiversity ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12921
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  • 77
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    Digitale Medien
    Inducible isopentenyl transferase as a high-efficiency marker for plant transformation (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 916-919 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Overexpression of the isopentenyltransferase gene (ipt) from the Ti-plasmid of Agrobacterium tumefaciens increases cytokinin levels, leading to generation of shoots from transformed plant cells. When combined with a dexamethasone-inducible system for controlling expression, ipt expression can ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12914
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  • 78
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    Digitale Medien
    The philosopher as biologist (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 926-927 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] ... Holmes Rolston III is a philosopher, and Genes, Genesis and God derives from his set of Gifford Lectures, a distinguished series given at the University of Edinburgh on the subject of natural theology. Rolston's presentation of his own natural theology, wherein the Spirit of God, both ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12924
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  • 79
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    Digitale Medien
    People (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 928-928 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Genomica Corp. (Boulder, CO) has appointed Teresa W. Ayers chief executive officer and director. Thomas G. Marr, who founded the company, retains his positions as president, chief scientist, and director. Ms. Ayers was most recently president and CEO of BioStar Inc. ArQule (Medford, MA) has ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12926
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  • 80
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    Digitale Medien
    New Products (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 929-929 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] HIGH-THROUGHPUT SCREENING & ASSAYS ... Storage system The Mol Bank from Tecan (Hombrechtikon, Switzerland) is a compact plate storage system for high-throughput laboratories. Mol Bank holds over 2,500 microplates or any combination of microplates and deep-well plates; just a few units ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12928
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  • 81
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    Digitale Medien
    Cardiovascular disease drug discovery (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 930-931 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Cardiovascular diseases cause more than 15 million deaths in the world each year, according to the World Health Organization (WHO; Geneva). They account for 50% of all deaths in several developed countries, and more than 50% in Africa and Western and Southeast Asia. They are also the major cause of ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/12935
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  • 82
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    Digitale Medien
    Biotechnology and world agriculture (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 729-729 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] By now, pretty much everyone has an opinion about agricultural biotechnology. Genetically modified (GM) crops will either be the salvation of unborn billions, or wreak havoc on human health and global ecology. But one thing we can all agree on is that the stakes are high and getting higher. ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/11610
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  • 83
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    Digitale Medien
    EST patent granted for human kinase homologs (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 125-125 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In November 1998, the US Patent and Trademark Office (PTO; Washington, DC) awarded Incyte Pharmaceuticals (Palo Alto, CA) the first patent for an expressed sequence tag (EST)—a gene fragment containing partial cDNAs of expressed mRNAs—claiming polynucleotides that identify and ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6119
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  • 84
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    Digitale Medien
    deCODE looks forward as database law passes (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 127-127 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The bill that would allow deCODE Genetics (Reykjavik) to establish a centralized database of Iceland's health records was voted into law in the Icelandic Parliament on December 17, 1998. As stipulated in the new law, it will be at least six months before any data can be entered into the ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6124
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  • 85
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    Digitale Medien
    Reconstructing the urinary bladder (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 133-134 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] An important goal of tissue–engineering technology is to develop tissue grafts for surgically repairing or replacing diseased human organs. For sufferers of several bladder diseases, replacement of the bladder wall as well as its physiological lining, the urothelium, can in some cases offer ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6132
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  • 86
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    Digitale Medien
    Human ES cells: Can you build a business around them? (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 139-142 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Phenomenal potential—and significant difficulty—accompanies the development of this ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6140
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  • 87
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    Digitale Medien
    Photopolymerizable degradable polyanhydrides with osteocompatibility (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 156-159 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] We have developed a new family of photopolymerizable, methacrylated anhydride monomers and oligomers that combine high strength, controlled degradation, and photoprocessibility in a singular system. Networks with degradation times ranging from 1 week to nearly 1 year and that retain up to 90% of ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6152
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  • 88
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    Digitale Medien
    Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'γ) 2 antibody (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 181-186 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] We have developed a system for the targeted delivery of adeno–associated virus (AAV) vectors. Targeting is achieved via a bispecific F(ab´)2 antibody that mediates a novel interaction between the AAV vector and a specific cell surface receptor expressed on human megakaryocytes. Targeted ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6185
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  • 89
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    Digitale Medien
    The price of everything (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 736-736 
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    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] What's in a title? Well, about £15,000 (US$23,000) a year if you're in charge of research and development at a UK biotechnology-based company, according to a new survey* of 54 UK companies from accountants, PriceWaterhouseCoopers (London). For "Heads of R&D", the median salary is ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/11629
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  • 90
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    Digitale Medien
    New Japan association for biotech commerce (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 736-736 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In June, heads of 51 major Japanese companies launched the Japan Bioindustrialists' Association, an independent organization that will represent and support biotechnology-related industries in Japan. The move comes in response to growing concern that Japan lacks a strong biotechnology industry ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/11627
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  • 91
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    Digitale Medien
    Huia cloned back to life? (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 736-736 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In July, the Maori tribe Ngati Huia agreed to support the cloning of the Huia, an extinct bird that once flourished in New Zealand. The decision was made during a conference held in Hastings where scientists and ethicists considered the associated technical and ethical issues. The conference was ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/11628
    Standort Signatur Erwartet Verfügbarkeit
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  • 92
    Digitale Medien
    Digitale Medien
    Biopharmaceutical sector performance, 2nd quarter 1999 (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 736-736 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/11630
    Standort Signatur Erwartet Verfügbarkeit
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  • 93
    Digitale Medien
    Digitale Medien
    Noninvasive visualization of tumors in rodent dorsal skin window chambers (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 1033-1035 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A novel model for evaluating anti-cancer ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/13736
    Standort Signatur Erwartet Verfügbarkeit
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  • 94
    Digitale Medien
    Digitale Medien
    People (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 1036-1036 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] David S. Barlowhas been named to Enzon's (Piscataway, NJ) board of directors. He is currently president of pharmaceuticals at Sepracor. Biogen (Cambridge, MA) has announced the appointment of Kees Been as vice president, business and market development, a new position. Mr. Been joins Biogen ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/13740
    Standort Signatur Erwartet Verfügbarkeit
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  • 95
    Digitale Medien
    Digitale Medien
    BIA drafts code of practice (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 737-737 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In the light of the rapid and recent falls from grace of companies such as British Biotech (Oxford, UK) and Cortecs (Isleworth, UK), the UK trade organization the BioIndustry Association proposed a code of conduct on July 8 that urges companies to seek external advice both on matters that have ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/11637
    Standort Signatur Erwartet Verfügbarkeit
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  • 96
    Digitale Medien
    Digitale Medien
    Gene knockouts in time and space (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 1051-1051 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] On page 1093, Lee and colleagues describe a useful tool for the mouse geneticist—a system for knocking out gene function with precise control over the developmental stage, cell type, and site of the affected tissue. The system uses the bacteriophage Cre-lox system; Cre recombinase ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/15020
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
    Digitale Medien
    Digitale Medien
    Research collaborations (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 737-737 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/11640
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
    Digitale Medien
    Digitale Medien
    Plant PKS structure revealed (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 738-738 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To date, very little structural information has been garnered on polyketide synthases (PKSs), enzymes responsible for producing a wide variety of metabolites, from plant pigments/antimicrobial phytoalexins to streptomycete macrolide antibiotics. Now, an international team has determined for the ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/11643
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
    Digitale Medien
    Digitale Medien
    People (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 203-203 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Dick Anderson has been appointed president and chief operating officer of NeoRx (Seattle, WA). Mr. Anderson joined the company in 1997 as senior vice president and chief financial officer, and has been senior vice president, finance and operations since January 1998. AxCell Biosciences ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/6213
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
    Digitale Medien
    Digitale Medien
    Seminal vesicle production and secretion of growth hormone into seminal fluid (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 1087-1090 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Production of foreign proteins in the tissues of transgenic animals represents an efficient and economical method of producing therapeutic and pharmaceutical proteins. In this study, we demonstrate that the mouse P12 gene promoter specific to the male accessory sex gland can be used to generate ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/15067
    Standort Signatur Erwartet Verfügbarkeit
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