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  • Articles  (8)
  • discovery
  • Springer  (8)
  • National Academy of Sciences
  • 1995-1999  (8)
  • 1975-1979
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  • Articles  (8)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 52 (1996), S. 5-13 
    ISSN: 1420-9071
    Keywords: Cyclosporin A ; Sandimmune® ; ovalicin ; cytochalasin ; fungus metabolites ; history ; discovery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The immunosuppressant cyclosporin A (Sandimmune®) has become the first line treatment for preventing rejection of transplanted organs and for certain, autoimmune diseases. The discovery of that drug and its preclinical development are described, and it is shown that most earlier accounts of the history of this compound are, in important respects, incorrect and misleading.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Foundations of science 4 (1999), S. 325-336 
    ISSN: 1572-8471
    Keywords: discovery ; creativity ; methodology ; adaptive logics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Natural Sciences in General
    Notes: Abstract In this paper, I argue that logic hasan important role to play in the methodological studyof creativity. I also argue, however, that onlyspecial kinds of logic enable one to understand thereasoning involved in creative processes. I show thatdeductive and ampliative adaptive logics areappropriate tools in this respect.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Foundations of science 4 (1999), S. 357-370 
    ISSN: 1572-8471
    Keywords: discovery ; Feyerabend ; Kepler ; rationality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Natural Sciences in General
    Notes: Abstract In this paper I argue against the traditional viewthat in discovery processes there is no place forrational decisions. First I argue that some historicalprocesses in which an empirical law was developed,were rational. Second, I identify some of themethodological rules that we can follow in order to berational when constructing an empirical law. Finally,I argue that people who deny that scientific discoverycan be rational do not understand the nature ofmethodological rules.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Foundations of science 4 (1999), S. 405-426 
    ISSN: 1572-8471
    Keywords: discovery ; Heisenberg ; heuristics ; Pauli ; quantum theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Natural Sciences in General
    Notes: Abstract This article analyses an episode in the earlyhistory of quantum theory: the controversy betweenPauli and Heisenberg about the anomalous Zeemaneffect, which was a main stumbling block for the oldquantum theory of Bohr. It is argued that theindividual philosophical views of both Pauli andHeisenberg directed their attempts to solve theanomaly and decisively influenced the solutions theyproposed. The results of this case study arecompared with the assertions of four theories ofscientific change, namely those of Kuhn, Lakatos,Laudan and Giere.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Foundations of science 4 (1999), S. 483-495 
    ISSN: 1572-8471
    Keywords: discovery ; drug lead ; pharmacy ; philosophy of medicine ; qualitative reasoning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Natural Sciences in General
    Notes: Abstract How can new drug lead suggestions beinferred from neurophysiological models? This paperaddresses this question based on a case study ofresearch into Parkinson's disease at the GroningenUniversity Department of Pharmacy. It is argued thatneurophysiological box-and-arrow models can beunderstood as qualitative differential equationmodels. An inference task is defined to helpunderstand and possibly aid the discovery andexplanation of new drug lead suggestions.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal for general philosophy of science 26 (1995), S. 119-134 
    ISSN: 1572-8587
    Keywords: discovery ; heuristics ; functional language
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Summary This paper provides an explication and defense of a view that many philosophers and biologists have accepted though few have understood, the idea that functional language can play an important role in biological discovery. I defend four theses in support of this view: (1) functional statements can serve as background assumptions that produce research problems; (2) functional questions can be important parts of research problems; (3) functional concepts can provide a framework for developing general theories; (4) functional statements can serve as heuristics for generating hypotheses. I develop and defend these four claims by describing a taxonomy of functional discourse, providing an account of scientific discovery, and by applying this framework to some cases of successful research in biology.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Minds and machines 5 (1995), S. 561-581 
    ISSN: 1572-8641
    Keywords: Cognitive unconscious ; discovery ; insight
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Philosophy
    Notes: Abstract The Greeks had a ready answer for what happens when the mind suddenly finds the answer to a question for which it had been searching: insight was regarded as a gift of the Muses, its origins were ‘divine’. It served to highlight the Greeks' belief that there are some things which are not meant to be scientifically explained. The essence of insight is that it comes from some supernatural source: unpredicted and unfettered. In other words, the origins of insight are unconscious, and hence, unexplainable. Wittgenstein felt that, as long as there continues to be a noun expression like ‘to have a moment of insight’ which functions in the same way as the expression ‘to have a hunger pang’, thereby inducing us to treat ‘moment of insight’ as the name of an experience, then “people will keep stumbling over the same puzzling difficulties and find themselves staring at something which no explanation seems capable of clearing up.” To the founders of AI, this argument reeked of obscurantism. The moment of insight, they felt, is indeed a mystery, but it is one that begs to be explained in causal terms. Indeed, the problem of insight served as one of the leading problems in the evolution of AI. Hence anyone interested in the foundations of AI is compelled to examine the manner in which the early pioneers of the field sought to explain the ‘eureka experience’. In this paper I will look at some of the key conceptual developments which paved the way for Newell and Simon's theory of GPS: the fundamental changes in the notion of the unconscious — the emergence of the ‘cognitive unconscious’ — which took place in the nineteenth- and early twentieth-century. In so doing, I hope to clarify what Wittgenstein may have had in mind in his strictures against mechanist attempts to analyse the nature of insight.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Biology and philosophy 14 (1999), S. 55-63 
    ISSN: 1572-8404
    Keywords: abduction ; discovery ; Nickles ; novelty ; serendipity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Philosophy
    Notes: Abstract Thomas Nickles challenges my thesis that innovative discoveries can be based on deliberately chosen problems and research strategies. He suggests that all significant innovation can be seen as such only in retrospect and that its generation must be serendipitous. Here I argue in response that significant innovations can and do often arise from self conscious critical appraisal of orthodox practice combined with regulated though speculative abductive argumentation to alternative explanatory schemata. Orthodox practice is not based upon monolithic systems of belief about the subject of inquiry. Rather major domains of scientific practice often are approached from different conceptualizations that provide grounds for critical dialectic and consilient empirical information. Abductive arguments that meet appropriate conditions of likelihood, probability and analogy are an important means of justifying allocating resources to innovative practices that have yet to produce products that can rival those of established orthodoxy.
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