Publication Date:
2006-07-15
Description:
Mekel-Bobrov et al. and Evans et al. (Reports, 9 Sept. 2005, p. 1720 and p. 1717, respectively) examined sequence data from modern humans within two gene regions associated with brain development, ASPM and microcephalin, and concluded that selection of these genes must be ongoing. We show that models of human history that include both population growth and spatial structure can generate the observed patterns without selection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Currat, Mathias -- Excoffier, Laurent -- Maddison, Wayne -- Otto, Sarah P -- Ray, Nicolas -- Whitlock, Michael C -- Yeaman, Sam -- New York, N.Y. -- Science. 2006 Jul 14;313(5784):172; author reply 172.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16840683" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Biological
;
Biological Evolution
;
Brain
;
Demography
;
Founder Effect
;
Gene Frequency
;
*Haplotypes
;
Humans
;
Models, Theoretical
;
Nerve Tissue Proteins/*genetics
;
Organ Size
;
Population Density
;
*Population Growth
;
Selection, Genetic
;
*Sequence Analysis, DNA
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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