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  • Humans  (3,279)
  • American Association for the Advancement of Science (AAAS)  (3,279)
  • 2010-2014  (3,279)
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  • 1
    Publication Date: 2014-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- Kaiser, Jocelyn -- Service, Robert F -- Gibbons, Ann -- Vogel, Gretchen -- Underwood, Emily -- Hand, Eric -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1444-9. doi: 10.1126/science.346.6216.1444. Epub 2014 Dec 18.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525224" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*trends ; Humans ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becher, Oren J -- Wechsler-Reya, Robert J -- R01 CA159859/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1458-9. doi: 10.1126/science.aaa3814.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Pediatric Hematology-Oncology, Department of Pathology, and Preston Robert Tisch Brain Tumor Center, Duke University, Durham, NC, 27710, USA. rwreya@sanfordburnham.org oren.becher@duke.edu. ; Tumor Initiation & Maintenance Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA. rwreya@sanfordburnham.org oren.becher@duke.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525232" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Stem Neoplasms/*genetics ; Cell Transformation, Neoplastic/*genetics ; Embryonic Stem Cells/*metabolism ; Glioma/*genetics ; Histones/*genetics ; Humans ; *Models, Genetic ; Neural Stem Cells/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1450-1. doi: 10.1126/science.346.6216.1450-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525227" target="_blank"〉PubMed〈/a〉
    Keywords: *Global Health ; Hemorrhagic Fever, Ebola/*epidemiology ; Humans ; Liberia/epidemiology ; Missionaries ; World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2014 Dec 19;346(6216):1450. doi: 10.1126/science.346.6216.1450-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525226" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*trends ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2014 Dec 19;346(6216):1449. doi: 10.1126/science.346.6216.1449.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525225" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*ethics/*trends ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2014-12-20
    Description: The conservation of large carnivores is a formidable challenge for biodiversity conservation. Using a data set on the past and current status of brown bears (Ursus arctos), Eurasian lynx (Lynx lynx), gray wolves (Canis lupus), and wolverines (Gulo gulo) in European countries, we show that roughly one-third of mainland Europe hosts at least one large carnivore species, with stable or increasing abundance in most cases in 21st-century records. The reasons for this overall conservation success include protective legislation, supportive public opinion, and a variety of practices making coexistence between large carnivores and people possible. The European situation reveals that large carnivores and people can share the same landscape.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapron, Guillaume -- Kaczensky, Petra -- Linnell, John D C -- von Arx, Manuela -- Huber, Djuro -- Andren, Henrik -- Lopez-Bao, Jose Vicente -- Adamec, Michal -- Alvares, Francisco -- Anders, Ole -- Balciauskas, Linas -- Balys, Vaidas -- Bedo, Peter -- Bego, Ferdinand -- Blanco, Juan Carlos -- Breitenmoser, Urs -- Broseth, Henrik -- Bufka, Ludek -- Bunikyte, Raimonda -- Ciucci, Paolo -- Dutsov, Alexander -- Engleder, Thomas -- Fuxjager, Christian -- Groff, Claudio -- Holmala, Katja -- Hoxha, Bledi -- Iliopoulos, Yorgos -- Ionescu, Ovidiu -- Jeremic, Jasna -- Jerina, Klemen -- Kluth, Gesa -- Knauer, Felix -- Kojola, Ilpo -- Kos, Ivan -- Krofel, Miha -- Kubala, Jakub -- Kunovac, Sasa -- Kusak, Josip -- Kutal, Miroslav -- Liberg, Olof -- Majic, Aleksandra -- Mannil, Peep -- Manz, Ralph -- Marboutin, Eric -- Marucco, Francesca -- Melovski, Dime -- Mersini, Kujtim -- Mertzanis, Yorgos -- Myslajek, Robert W -- Nowak, Sabina -- Odden, John -- Ozolins, Janis -- Palomero, Guillermo -- Paunovic, Milan -- Persson, Jens -- Potocnik, Hubert -- Quenette, Pierre-Yves -- Rauer, Georg -- Reinhardt, Ilka -- Rigg, Robin -- Ryser, Andreas -- Salvatori, Valeria -- Skrbinsek, Tomaz -- Stojanov, Aleksandar -- Swenson, Jon E -- Szemethy, Laszlo -- Trajce, Aleksander -- Tsingarska-Sedefcheva, Elena -- Vana, Martin -- Veeroja, Rauno -- Wabakken, Petter -- Wolfl, Manfred -- Wolfl, Sybille -- Zimmermann, Fridolin -- Zlatanova, Diana -- Boitani, Luigi -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1517-9. doi: 10.1126/science.1257553.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Grimso Wildlife Research Station, Department of Ecology, Swedish University of Agricultural Sciences, 73091 Riddarhyttan, Sweden. gchapron@carnivoreconservation.org guillaume.chapron@slu.se. ; Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Savoyenstrasse 1, 1160 Vienna, Austria. ; Norwegian Institute for Nature Research, Post Office Box 5685 Sluppen, 7485 Trondheim, Norway. ; KORA, Thunstrasse 31, 3074 Muri bei Bern, Switzerland. ; Biology Department of the Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia. ; Grimso Wildlife Research Station, Department of Ecology, Swedish University of Agricultural Sciences, 73091 Riddarhyttan, Sweden. ; Grimso Wildlife Research Station, Department of Ecology, Swedish University of Agricultural Sciences, 73091 Riddarhyttan, Sweden. Research Unit of Biodiversity (UO/CSIC/PA), Oviedo University, 33600 Mieres, Spain. ; State Nature Conservancy of Slovak Republic, Tajovskeho 28B, 974 01 Banska Bystrica, Slovakia. ; CIBIO/InBio, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, 4485-661 Vairao, Portugal. ; Harz Nationalpark, Lindenallee 35, 38855 Wernigerode, Germany. ; Nature Research Centre, Akademijos 2, 08412 Vilnius, Lithuania. ; Association for Nature Conservation "Baltijos vilkas," Visoriu 6A-54, 08300 Vilnius, Lithuania. ; Slovak Wildlife Society, Post Office Box 72, 03301 Liptovsky Hradok, Slovakia. ; Biology Department of the Faculty of Natural Sciences, University of Tirana, Boulevard Zog I, Tirana, Albania. ; Wolf Project, Consultores en Biologia de la Conservacion, Calle Manuela Malasana 24, 28004 Madrid, Spain. ; KORA, Thunstrasse 31, 3074 Muri bei Bern, Switzerland. Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Langgassstrasse 122, 3012 Bern, Switzerland. ; Department of Game Management and Wildlife Biology, Czech University of Life Sciences in Prague, Kamycka 129, 165 21 Prague, Czech Republic. ; Ministry of Environment of the Republic of Lithuania, Jaksto 4/9, 01105 Vilnius, Lithuania. ; Department of Biology and Biotechnologies, University of Rome "La Sapienza," Viale dell'Universita 32, 00185 Roma, Italy. ; Balkani Wildlife Society, Boulevard Dragan Tzankov 8, 1164 Sofia, Bulgaria. ; Lynx Project Austria Northwest, Linzerstrasse 14, 4170 Haslach/Muhl, Austria. ; Nationalpark Kalkalpen, Nationalpark Zentrum Molln, Nationalpark Allee 1, 4591 Molln, Austria. ; Provincia Autonoma di Trento - Servizio Foreste e Fauna, Via Trener no. 3, 38100 Trento, Italy. ; Finnish Game and Fisheries Research Institute, Viikinkaari 4, 00790 Helsinki, Finland. ; Protection and Preservation of Natural Environment in Albania, Rruga Vangjush Furxhi 16/1/10, Tirana, Albania. ; Callisto Wildlife and Nature Conservation Society, Mitropoleos 123, 54621 Thessaloniki, Greece. ; Faculty of Silviculture and Forest Engineering, Department of Silviculture, Transilvania University, 1 Beethoven Lane, 500123 Brasov, Romania. Forest Research Institute (ICAS) Bulevardul Eroilor Number 128, Voluntari, Ilfov, 077190 Romania. ; State Institute for Nature Protection, Trg Mazuranica 5, 10000 Zagreb, Croatia. ; University of Ljubljana, Biotechnical Faculty, Jamnikarjeva 101, 1000 Ljubljana, Slovenia. ; LUPUS - German Institute for Wolf Mnitoring and Research, Dorfstrasse 20, 02979 Spreewitz, Germany. ; Finnish Game and Fisheries Research Institute, Oulu Game and Fisheries Research, Tutkijantie 2E, 90570 Oulu, Finland. ; Department of Forest Protection and Game Management, Faculty of Forestry, Technical University of Zvolen, T.G. Masaryka 20, 960 53 Zvolen, Slovakia. ; Faculty of Forestry, University of Sarajevo, Zagrebacka 20, 71000 Sarajevo, Bosnia and Herzegovina. ; Department of Forest Protection and Wildlife Management, Faculty of Forestry and Wood Technology, Mendel University in Brno, Zemedelska 3, 61300 Brno, Czech Republic. Friends of the Earth Czech Republic, Olomouc Branch, Dolni Namesti 38, 77900 Olomouc, Czech Republic. ; Estonian Environment Agency, Roomu tee 2, 51013 Tartu, Estonia. ; Office National de la Chasse et de la Faune Sauvage, ZI Mayencin, 5 Allee de Bethleem, 38610 Gieres, France. ; Centro Gestione e Conservazione Grandi Carnivori, Piazza Regina Elena 30, Valdieri 12010, Italy. ; Macedonian Ecological Society, Arhimedova 5, Skopje 1000, FYR Macedonia. Department of Wildlife Sciences, Georg-August University, Busgenweg 3, 37077 Gottingen, Germany. ; National Veterinary Epidemiology Unit, Food Safety and Veterinary Institute, Rruga Aleksander Moisiu 10 Tirana, Albania. ; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106 Warszawa, Poland. ; Association for Nature "Wolf," Twardorzeczka 229, 34-324 Lipowa, Poland. ; Latvian State Forest Research Institute "Silava," Rigas Iela 111, Salaspils, 2169 Latvia. ; Fundacion Oso Pardo, Calle San Luis 17, 4 degrees A, 39010 Santander, Spain. ; Natural History Museum, Njegoseva 51, 11000 Belgrade, Serbia. ; ONCFS-CNERA PAD, Equipe Ours, Chef de Projet, Impasse de la Chapelle, 31800 Villeneuve de Riviere, France. ; Istituto di Ecologia Applicata, Via B. Eustachio 10, 00161 Rome, Italy. ; Macedonian Ecological Society, Arhimedova 5, Skopje 1000, FYR Macedonia. ; Norwegian Institute for Nature Research, Post Office Box 5685 Sluppen, 7485 Trondheim, Norway. Department of Ecology and Natural Resource Management, Norwegian University of Life Sciences, Postbox 5003, 1432 As, Norway. ; St. Istvan Unversity Institute for Wildlife Conservation, Pater Karoly 1, 2103 Godollo, Hungary. ; Friends of the Earth Czech Republic, Olomouc Branch, Dolni Namesti 38, 77900 Olomouc, Czech Republic. ; Hedmark University College, Evenstad, 2480 Koppang, Norway. ; Bavarian Agency of Environment, Hans-Hogn-Strasse 12, 95030 Hof/Saale, Germany. ; Lynx Project Bavaria, Trailling 1a, 93462 Lam, Germany. ; Department of Zoology and Anthropology, Faculty of Biology/Sofia University "St. Kliment Ohridski," Boulevard Dragan Tzankov 8, 1164 Sofia, Bulgaria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525247" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; *Conservation of Natural Resources ; Europe ; Humans ; *Lynx ; *Mustelidae ; *Ursidae ; *Wolves
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2014-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorsch, Jon R -- Collins, Francis S -- Lippincott-Schwartz, Jennifer -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1452-3. doi: 10.1126/science.1259110.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Director, National Institute of General Medical Sciences, Bethesda, MD 20892, USA. jon.lorsch@nih.gov. ; Director, National Institutes of Health, Bethesda, MD 20892, USA. ; President, American Society for Cell Biology, Bethesda, MD 20814, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525228" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Specimen Banks/*standards ; Biomedical Research/*standards ; *Cell Line ; Drug Evaluation, Preclinical/*standards ; Humans ; National Institutes of Health (U.S.) ; Policy ; *Reproducibility of Results ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2014-12-20
    Description: Over 70% of diffuse intrinsic pediatric gliomas, an aggressive brainstem tumor, harbor heterozygous mutations that create a K27M amino acid substitution (methionine replaces lysine 27) in the tail of histone H3.3. The role of the H3.3K27M mutation in tumorigenesis is not fully understood. Here, we use a human embryonic stem cell system to model this tumor. We show that H3.3K27M expression synergizes with p53 loss and PDGFRA activation in neural progenitor cells derived from human embryonic stem cells, resulting in neoplastic transformation. Genome-wide analyses indicate a resetting of the transformed precursors to a developmentally more primitive stem cell state, with evidence of major modifications of histone marks at several master regulator genes. Drug screening assays identified a compound targeting the protein menin as an inhibitor of tumor cell growth in vitro and in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Funato, Kosuke -- Major, Tamara -- Lewis, Peter W -- Allis, C David -- Tabar, Viviane -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1529-33. doi: 10.1126/science.1253799. Epub 2014 Nov 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurosurgery, Center for Stem Cell Biology and Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. ; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA. ; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA. ; Department of Neurosurgery, Center for Stem Cell Biology and Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. tabarv@mskcc.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525250" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antineoplastic Agents/pharmacology ; Brain Stem Neoplasms/*genetics/pathology ; Cell Transformation, Neoplastic/*genetics/pathology ; Child ; Drug Screening Assays, Antitumor ; Embryonic Stem Cells/*metabolism/pathology ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Genome-Wide Association Study ; Glioma/*genetics/pathology ; Histones/*genetics ; Humans ; Mice ; *Models, Genetic ; Neural Stem Cells/*metabolism/pathology ; Proto-Oncogene Proteins/antagonists & inhibitors ; Tumor Suppressor Protein p53/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2014-12-20
    Description: Immunological tolerance to self requires naturally occurring regulatory T (Treg) cells. Yet how they stably control autoimmune T cells remains obscure. Here, we show that Treg cells can render self-reactive human CD8(+) T cells anergic (i.e., hypoproliferative and cytokine hypoproducing upon antigen restimulation) in vitro, likely by controlling the costimulatory function of antigen-presenting cells. Anergic T cells were naive in phenotype, lower than activated T cells in T cell receptor affinity for cognate antigen, and expressed several coinhibitory molecules, including cytotoxic T lymphocyte-associated antigen-4 (CTLA-4). Using these criteria, we detected in healthy individuals anergic T cells reactive with a skin antigen targeted in the autoimmune disease vitiligo. Collectively, our results suggest that Treg cell-mediated induction of anergy in autoimmune T cells is important for maintaining self-tolerance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maeda, Yuka -- Nishikawa, Hiroyoshi -- Sugiyama, Daisuke -- Ha, Danbee -- Hamaguchi, Masahide -- Saito, Takuro -- Nishioka, Megumi -- Wing, James B -- Adeegbe, Dennis -- Katayama, Ichiro -- Sakaguchi, Shimon -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1536-40. doi: 10.1126/science.aaa1292.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Immunology, Immunology Frontier Research Center (IFReC-WPI), Osaka University, Osaka 565-0871, Japan. ; Experimental Immunology, Immunology Frontier Research Center (IFReC-WPI), Osaka University, Osaka 565-0871, Japan. shimon@ifrec.osaka-u.ac.jp nisihiro@ifrec.osaka-u.ac.jp. ; Experimental Immunology, Immunology Frontier Research Center (IFReC-WPI), Osaka University, Osaka 565-0871, Japan. Department of Dermatology, Graduate School of Medicine, Osaka University, Osaka565-0871, Japan. ; Department of Dermatology, Graduate School of Medicine, Osaka University, Osaka565-0871, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525252" target="_blank"〉PubMed〈/a〉
    Keywords: Antigen-Presenting Cells/immunology ; Autoimmune Diseases/*immunology ; CD8-Positive T-Lymphocytes/*immunology ; CTLA-4 Antigen ; *Clonal Anergy ; Humans ; Lymphocyte Activation ; Receptors, Antigen, T-Cell/immunology ; *Self Tolerance ; T-Lymphocytes, Regulatory/*immunology ; Vitiligo/immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1441. doi: 10.1126/science.346.6216.1441.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525222" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Child ; *Child Development ; Child Welfare/*economics ; Federal Government ; Humans ; National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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