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  • Artikel  (3.756)
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  • 11
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    Genetics. FDA races in wrong direction (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-07-26
    Beschreibung: Despite recent genetic evidence and the promise of individualized medicine, there is a continuing interest in using self-identified categories of race and ethnicity as variables in scientific and medical research. The U.S. Food and Drug Administration recently proposed a standardized approach for the collection of race and ethnicity data in clinical trials. We believe that this move fails to acknowledge new scientific data and recommend that relevant data from individuals be collected and used rather than broad group statistics. We also encourage that increased funding be committed to this important issue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haga, Susanne B -- Venter, J Craig -- New York, N.Y. -- Science. 2003 Jul 25;301(5632):466.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Advancement of Genomics, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12881555" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Clinical Trials as Topic ; *Continental Population Groups/genetics ; *Ethnic Groups/genetics ; Gene Frequency ; Genetic Variation ; Guidelines as Topic ; Humans ; Pharmacogenetics ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 12
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    Environmental Protection Agency. Access to proposals triggers sharp debate (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-03-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Renner, Rebecca -- New York, N.Y. -- Science. 2003 Mar 7;299(5612):1501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12624242" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Access to Information ; Government Agencies ; *Intellectual Property ; National Institutes of Health (U.S.) ; Privacy ; Research Support as Topic ; United States ; *United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 13
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    Ethics. Revisiting a 1930s scandal, AACR to rename a prize (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-04-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Starr, Douglas -- New York, N.Y. -- Science. 2003 Apr 25;300(5619):573-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12714721" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Awards and Prizes ; Ethics, Research/*history ; History, 20th Century ; *Neoplasms/history ; Prejudice ; Puerto Rico ; *Societies, Scientific ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 14
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    Homeland security. New agency contains strong science arm (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-11-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2002 Nov 22;298(5598):1534.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12446877" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Bioterrorism ; Financing, Government ; Government Agencies/economics/legislation & jurisprudence/*organization & ; administration ; National Institutes of Health (U.S.) ; Research/*organization & administration ; Research Support as Topic ; Security Measures/economics/legislation & jurisprudence/*organization & ; administration ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 15
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    Historical essay. The early years of HIV/AIDS (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-12-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallo, Robert C -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1728-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459576" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Serodiagnosis/history ; Acquired Immunodeficiency Syndrome/diagnosis/*history/immunology/virology ; CD4-Positive T-Lymphocytes/virology ; Cell Line ; Cells, Cultured ; France ; *HIV/classification/isolation & purification/physiology ; History, 20th Century ; Human T-lymphotropic virus 1/isolation & purification/physiology ; Human T-lymphotropic virus 2/isolation & purification/physiology ; Humans ; Interleukin-2/history/isolation & purification/physiology ; Patents as Topic/history ; RNA-Directed DNA Polymerase/history/isolation & purification/metabolism ; United States ; Virus Cultivation
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 16
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    Research fraud, public policy, and gun control (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-06-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lott, John R Jr -- New York, N.Y. -- Science. 2003 Jun 6;300(5625):1505; author reply 1505.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12791965" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Crime/statistics & numerical data ; *Firearms/legislation & jurisprudence ; *Public Policy ; Publishing ; Research/*standards ; Scientific Misconduct ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    AIDS and Africa: still a sad story (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-05-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2003 May 16;300(5622):1053.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12750481" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*economics/epidemiology/prevention & ; control/transmission ; Africa/epidemiology ; Disease Outbreaks/economics ; Financing, Government ; Health Care Costs ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; South Africa/epidemiology ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 18
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    An uncertain partnership (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-11-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mulcahy, R Timothy -- New York, N.Y. -- Science. 2003 Nov 7;302(5647):949.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14605331" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*legislation & jurisprudence ; Bioterrorism/*legislation & jurisprudence/prevention & control ; *Government Regulation ; *Security Measures ; United States ; *Universities
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 19
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    Polyubiquitination of p53 by a ubiquitin ligase activity of p300 (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-04-12
    Beschreibung: Rapid turnover of the tumor suppressor protein p53 requires the MDM2 ubiquitin ligase, and both interact with p300-CREB-binding protein transcriptional coactivator proteins. p53 is stabilized by the binding of p300 to the oncoprotein E1A, suggesting that p300 regulates p53 degradation. Purified p300 exhibited intrinsic ubiquitin ligase activity that was inhibited by E1A. In vitro, p300 with MDM2 catalyzed p53 polyubiquitination, whereas MDM2 catalyzed p53 monoubiquitination. E1A expression caused a decrease in polyubiquitinated but not monoubiquitinated p53 in cells. Thus, generation of the polyubiquitinated forms of p53 that are targeted for proteasome degradation requires the intrinsic ubiquitin ligase activities of MDM2 and p300.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grossman, Steven R -- Deato, Maria E -- Brignone, Chrystelle -- Chan, Ho Man -- Kung, Andrew L -- Tagami, Hideaki -- Nakatani, Yoshihiro -- Livingston, David M -- CA15751/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2003 Apr 11;300(5617):342-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12690203" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenovirus E1A Proteins/metabolism ; Animals ; Catalysis ; Cells, Cultured ; E1A-Associated p300 Protein ; Embryo, Mammalian ; Fibroblasts/metabolism ; Humans ; Ligases/antagonists & inhibitors/metabolism ; Mice ; Nuclear Proteins/antagonists & inhibitors/*metabolism ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-mdm2 ; Recombinant Fusion Proteins/metabolism ; Recombinant Proteins/metabolism ; Trans-Activators/antagonists & inhibitors/*metabolism ; Transfection ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/*metabolism ; Ubiquitin-Protein Ligases ; Ubiquitins/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 20
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    Calculating the benefits of regulation (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-05-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roelofs, Cora R -- Ellenbecker, Michael J -- New York, N.Y. -- Science. 2003 May 30;300(5624):1372.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12775824" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cost-Benefit Analysis ; Environmental Health ; *Government Regulation ; *Health ; Humans ; Safety ; United States ; *United States Occupational Safety and Health Administration ; *Value of Life
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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