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  • Articles  (4,084)
  • Institute of Electrical and Electronics Engineers (IEEE)  (4,084)
  • 2015-2019  (4,084)
  • Technology  (2,714)
  • Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics  (1,370)
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  • Articles  (4,084)
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  • 1
    Publication Date: 2015-08-21
    Description: Objective: To develop a pipeline for realistic head models of nonhuman primates (NHPs) for simulations of noninvasive brain stimulation, and use these models together with empirical threshold measurements to demonstrate that the models capture individual anatomical variability. Methods: Based on structural MRI data, we created models of the electric field (E-field) induced by right unilateral (RUL) electroconvulsive therapy (ECT) in four rhesus macaques. Individual motor threshold (MT) was measured with transcranial electric stimulation (TES) administered through the RUL electrodes in the same subjects. Results: The interindividual anatomical differences resulted in 57% variation in median E-field strength in the brain at fixed stimulus current amplitude. Individualization of the stimulus current by MT reduced the E-field variation in the target motor area by 27%. There was significant correlation between the measured MT and the ratio of simulated electrode current and E-field strength ( $r^{2} = 0.95$ , $p = 0.026$ ). Exploratory analysis revealed significant correlations of this ratio with anatomical parameters including of the superior electrode-to-cortex distance, vertex-to-cortex distance, and brain volume ( $r^{2} > 0.96$ , $p 〈 0.02$ ). The neural activation threshold was estimated to be $0.45 pm 0.07$ V/cm for 0.2-ms stimulus pulse width. Conclusion: These results suggest that our individual-specific NHP E-field models appropriately capture individual anatomical variability relevant to the dosing of TES/ECT. These findings are exploratory due to the small number of subjects. Sign- ficance: This study can contribute insight in NHP studies of ECT and other brain stimulation interventions, help link the results to clinical studies, and ultimately lead to more rational brain stimulation dosing paradigms.
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  • 2
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    Publication Date: 2015-08-21
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  • 3
    Publication Date: 2015-08-21
    Description: Ectopic electrical activity that originates in the peri-infarct region can give rise to potentially lethal re-entrant arrhythmias. The spatial variation in electrotonic loading that results from structural remodelling in the infarct border zone may increase the probability that focal activity will trigger electrical capture, but this has not previously been investigated systematically. This study uses in-silico experiments to examine the structural modulation of effective refractory period on ectopic beat capture. Informed by 3-D reconstructions of myocyte organization in the infarct border zone, a region of rapid tissue expansion is abstracted to an idealized representation. A novel metric is introduced that defines the local electrotonic loading as a function of passive tissue properties and boundary conditions. The effective refractory period correlates closely with local electrotonic loading, while the action potential duration, conduction, and upstroke velocity reduce in regions of increasing electrotonic load. In the presence of focal ectopic stimuli, spatial variation in effective refractory period can cause unidirectional conduction block providing a substrate for reentrant arrhythmias. Consequently, based on the observed results, a possible novel mechanism for arrhythmogenesis in the infarct border zone is proposed.
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  • 4
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    Publication Date: 2015-08-22
    Description: Prospective authors are requested to submit new, unpublished manuscripts for inclusion in the upcoming event described in this call for papers.
    Print ISSN: 1521-9615
    Electronic ISSN: 1558-366X
    Topics: Computer Science , Natural Sciences in General , Technology
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  • 5
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-08-22
    Description: Kalyani Nair reviews "Multiscale Modeling in Biomechanics and Mechanobiology", edited by S. De, W. Hwang, and E. Kuhl, declaring it useful for anyone looking to get a quick overview of the field over a broad spectrum of areas.
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  • 6
    Publication Date: 2015-08-21
    Description: Automatic processing and accurate diagnosis of pathological electrocardiogram (ECG) signals remains a challenge. As long-term ECG recordings continue to increase in prevalence, driven partly by the ease of remote monitoring technology usage, the need to automate ECG analysis continues to grow. In previous studies, a model-based ECG filtering approach to ECG data from healthy subjects has been applied to facilitate accurate online filtering and analysis of physiological signals. We propose an extension of this approach, which models not only normal and ventricular heartbeats, but also morphologies not previously encountered. A switching Kalman filter approach is introduced to enable the automatic selection of the most likely mode (beat type), while simultaneously filtering the signal using appropriate prior knowledge. Novelty detection is also made possible by incorporating a third mode for the detection of unknown (not previously observed) morphologies, and denoted as X-factor. This new approach is compared to state-of-the-art techniques for the ventricular heartbeat classification in the MIT-BIH arrhythmia and Incart databases. $F_1$ scores of $mathbf {98.3%}$ and $mathbf {99.5%}$ were found on each database, respectively, which are superior to other published algorithms’ results reported on the same databases. Only $mathbf {3%}$ of all the beats were discarded as X-factor, and the majority of these beats contained high levels of noise. The proposed technique demonstrates accurate beat classification in the presence of previously unseen (and unlearned) morphologies and noise, and provides an automated method for morphological analysis of arbitrary (unknown) ECG leads.
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  • 7
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    Publication Date: 2015-08-21
    Description: Objective : A hybrid imaging technique, ultrasound-modulated luminescence tomography, that uses ultrasound to modulate diffusely propagating light has been shown to improve the spatial resolution of optical images. This paper investigates the underlying modulation mechanisms and the feasibility of applying this technique to improve spatial resolution in bioluminescence tomography. Methods : Ultrasound-modulated bioluminescence tomography was studied numerically to identify the effects of four factors (reduced optical scattering coefficient, optical absorption coefficient, refractive index, and luciferase concentration) on the depth of light modulation. In practice, an open source finite-element method tool for simulation of diffusely propagating light, near infrared fluorescence and spectral tomography, was modified to incorporate the effects of ultrasound modulation. The signal-to-noise ratios of detected modulated bioluminescent emissions are calculated using the optical and physical properties of a mouse model. Results : The modulation depth of the bioluminescent emission affected by the US induced variation of local concentration of the light emitting enzyme luciferase was at least two orders of magnitude greater than that caused by variations in the other factors. For surface radiances above approximately $10^7$ $hbox{photons}$ / $hbox{s}$ / $hbox{cm}^{2}$ / $hbox{sr,}$ the corresponding SNRs are detectable with the currently available detector technologies. Conclusion : The dominant effect in generation of ultrasound-modulated bioluminescence is ultrasound induced variation in luciferase concentration. The SNR analysis confirms the- feasibility of applying ultrasound-modulated bioluminescence tomography in preclinical imaging of mice. Significance : The simulation model developed suggests ultrasound-modulated bioluminescence tomography is a potential technique to improve the spatial resolution of bioluminescence tomography.
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  • 8
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    Publication Date: 2015-08-21
    Description: Mechanical ventilation of patients with acute respiratory distress syndrome (ARDS) is a necessary life support measure which may lead to ventilator-induced lung injury, a complication that can be reduced or ameliorated by using appropriate tidal volumes and positive end-expiratory pressures. However, the optimal mechanical ventilation parameters are almost certainly different for each patient, and will vary with time as the injury status of the lung changes. In order to optimize mechanical ventilation in an individual ARDS patient, therefore, it is necessary to track the manner in which injury status is reflected in the mechanical properties of the lungs. Accordingly, we developed an algorithm for assessing the time-dependent manner in which different lung regions open (recruit) and close (derecruit) as a function of the pressure waveform that is applied to the airways during mechanical ventilation. We used this algorithm to test the notion that variable ventilation provides the dynamic perturbations in lung volume necessary to accurately identify recruitment/derecruitment dynamics in the injured lung. We performed this test on synthetic pressure and flow data generated with established numerical models of lung function corresponding to both healthy mice and mice with lung injury. The data were generated by subjecting the models to a variety of mechanical ventilation regimens including variable ventilation. Our results support the hypothesis that variable ventilation can be used as a diagnostic tool to identify the injury status of the lung in ARDS.
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  • 9
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-08-21
    Description: Goal: Many brain–computer interface (BCI) classification techniques rely on a large number of labeled brain responses to create efficient classifiers. A large database representing all of the possible variability in the signal is impossible to obtain in a short period of time, and prolonged calibration times prevent efficient BCI use. We propose to improve BCIs based on the detection of event-related potentials (ERPs) in two ways. Methods: First, we increase the size of the training database by considering additional deformed trials. The creation of the additional deformed trials is based on the addition of Gaussian noise, and on the variability of the ERP latencies. Second, we exploit the variability of the ERP latencies by combining decisions across multiple deformed trials. These new methods are evaluated on data from 16 healthy subjects participating in a rapid serial visual presentation task. Results: The results show a significant increase in the performance of single-trial detection with the addition of artificial trials, and the combination of decisions obtained from altered trials. When the number of trials to train a classifier is low, the proposed approach allows us improve performance from an AUC of $0.533pm 0.080$ to $0.905pm 0.053$ . This improvement represents approximately an 80% reduction in classification error. Conclusion: These results demonstrate that artificially increasing the training dataset leads to improved single-trial detection. Significance: Calibration sessions can be shortened for BCIs based on ERP detection.
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  • 10
    Publication Date: 2015-08-21
    Description: Goal: The existing ISFET-based DNA sequencing detects hydrogen ions released during the polymerization of DNA strands on microbeads, which are scattered into microwell array above the ISFET sensor with unknown distribution. However, false pH detection happens at empty microwells due to crosstalk from neighboring microbeads. In this paper, a dual-mode CMOS ISFET sensor is proposed to have accurate pH detection toward DNA sequencing. Methods: Dual-mode sensing, optical and chemical modes, is realized by integrating a CMOS image sensor (CIS) with ISFET pH sensor, and is fabricated in a standard 0.18-μm CIS process. With accurate determination of microbead physical locations with CIS pixel by contact imaging, the dual-mode sensor can correlate local pH for one DNA slice at one location-determined microbead, which can result in improved pH detection accuracy. Moreover, toward a high-throughput DNA sequencing, a correlated-double-sampling readout that supports large array for both modes is deployed to reduce pixel-to-pixel nonuniformity such as threshold voltage mismatch. Results: The proposed CMOS dual-mode sensor is experimentally examined to show a well correlated pH map and optical image for microbeads with a pH sensitivity of 26.2 mV/pH, a fixed pattern noise (FPN) reduction from 4% to 0.3%, and a readout speed of 1200 frames/s. Conclusion: A dual-mode CMOS ISFET sensor with suppressed FPN for accurate large-arrayed pH sensing is proposed and demonstrated with state-of-the-art measured results toward accurate and high-throughput DNA sequencing. Significance: The developed dual-mode CMOS ISFET sensor has great potential for future personal genome diagnostics with high accuracy and low cost.
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  • 11
    Publication Date: 2015-08-21
    Description: Goal : Visual feedback can be used during gait rehabilitation to improve the efficacy of training. We presented a paradigm called visual feedback distortion; the visual representation of step length was manipulated during treadmill walking. Our prior work demonstrated that an implicit distortion of visual feedback of step length entails an unintentional adaptive process in the subjects’ spatial gait pattern. Here, we investigated whether the implicit visual feedback distortion, versus conscious correction, promotes efficient locomotor adaptation that relates to greater retention of a task. Methods: Thirteen healthy subjects were studied under two conditions: (1) we implicitly distorted the visual representation of their gait symmetry over 14 min, and (2) with help of visual feedback, subjects were told to walk on the treadmill with the intent of attaining the gait asymmetry observed during the first implicit trial. After adaptation, the visual feedback was removed while subjects continued walking normally. Over this 6-min period, retention of preserved asymmetric pattern was assessed. Results: We found that there was a greater retention rate during the implicit distortion trial than that of the visually guided conscious modulation trial. Conclusion: This study highlights the important role of implicit learning in the context of gait rehabilitation by demonstrating that training with implicit visual feedback distortion may produce longer lasting effects. Significance: This suggests that using visual feedback distortion could improve the effectiveness of treadmill rehabilitation processes by influencing the retention of motor skills.
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  • 12
    Publication Date: 2015-08-21
    Description: This paper explores the development of biomechanical models for evaluating a new class of passive mechanical implants for orthopedic surgery. The proposed implants take the form of passive engineered mechanisms, and will be used to improve the functional attachment of muscles to tendons and bone by modifying the transmission of forces and movement inside the body. Specifically, we present how two types of implantable mechanisms may be modeled in the open-source biomechanical software OpenSim. The first implant, which is proposed for hand tendon-transfer surgery, differentially distributes the forces and movement from one muscle across multiple tendons. The second implant, which is proposed for knee-replacement surgery, scales up the forces applied to the knee joint by the quadriceps muscle. This paper's key innovation is that such mechanisms have never been considered before in biomechanical simulation modeling and in surgery. When compared with joint function enabled by the current surgical practice of using sutures to make the attachment, biomechanical simulations show that the surgery with 1) the differential mechanism (tendon network) implant improves the fingers’ ability to passively adapt to an object's shape significantly during grasping tasks (2.74× as measured by the extent of finger flexion) for the same muscle force, and 2) the force-scaling implant increases knee-joint torque by 84% for the same muscle force. The critical significance of this study is to provide a methodology for the design and inclusion of the implants into biomechanical models and validating the improvement in joint function they enable when compared with current surgical practice.
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  • 13
    Publication Date: 2015-08-21
    Description: The impact of pulse repetition rate (PRR) in modulating electroporation (EP) induced by nanosecond pulsed electric fields (nsPEFs) in mammalian cells was approached here by performing both biological and numerical analysis. Plasma membrane permeabilization and viability of Jurkat cells were analyzed after exposure to 500, 1.3 MV/m, 40 ns PEFs with variable PRR (2–30 Hz). A finite-element model was used to investigate EP dynamics in a single cell under the same pulsing conditions, by looking at the time course of transmembrane voltage and pore density on the ns time scale. The biological observations showed an increased EP and reduced viability of the exposed cells at lower PRR in the considered range. The numerical analysis resulted in different dynamics of plasma membrane response when ns pulses were delivered with different PRR, consistently with a phenomenon of electrodesensitization recently hypothesized by another research group.
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  • 14
    Publication Date: 2015-08-21
    Description: Gastroscopy plays an important role in the diagnosis of gastric disease. In this paper, we develop an image panoramic system to assist endoscopists in improving lesion surveillance and reducing many of the tedious operations associated with gastroscopy. The constructed panoramic view has two categories: 1) the local view broadens the endoscopist's field of view in real time. Combining with the original gastroscopic video, this mosaicking view enables the endoscopist to diagnose the lesion comprehensively; 2) the global view constructs a large-area panoramic scene of the internal gastric surface, which can be used for intraoperative surgical navigation and postoperative scene review. Due to the irregular texture and inconsistent reflection of the gastric internal surface, common registration methods cannot accurately stitch this surface. Thereby, a six degree of freedom position tracking endoscope is devised to accommodate for the accumulated mosaicking error and provide efficient mosaicking results. For the global view, a dual-cube constraint model and a Bundle Adjustment algorithm are incorporated to deal with the mosaicking error caused by the irregular inflation and nonrigid deformation of the stomach. Moreover, texture blending and frame selection schemes are developed to make the mosaicking results feasible in real-clinical applications. The experimental results demonstrate that our system performs with a speed of 7.12 frames/s in a standard computer environment, and the mosaicking mean error is 0.43 mm for local panoramic view and 3.71 mm for global panoramic view.
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  • 15
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    Publication Date: 2015-08-21
    Description: In this paper, we present a smart capsule for location-specific drug release in the gastrointestinal tract. Once activated through a magnetic proximity fuse, the capsule opens up and releases its powdered payload in a location specified by an implanted miniature magnetic marker or an externally worn larger magnet. The capsule (9 mm × 26 mm) comprises of two compartments: one contains a charged capacitor and a reed switch, while the second one houses the drug reservoir capped by a taut nylon thread intertwined with a nichrome wire. The nichrome wire is connected to the capacitor through the reed switch. The capacitor is charged to 2.7 V before ingestion and once within the proximity of the permanent magnet; the reed switch closes, discharging the capacitor through the nichrome wire, melting the nylon thread, detaching the cap, and emptying the drug reservoir.
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  • 16
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    Publication Date: 2015-08-21
    Description: Goal: The purpose of this paper was to evaluate a nitinol tine fixation design for a transcatheter pacemaker in order to determine if the tines could be easily deployed and safely removed from the myocardium, enable low, stable pacing thresholds, and minimize the potential for dislodgment. Methods: The penetration properties of 13 human hearts were compared to the deployment and fixation energy of the tines to determine if the tines could be easily deployed and removed from the myocardium. The safety factor for dislodgement was calculated by comparing the kinetic energy of the device to the fixation energy of the tines. The fixation stability was tested in 113 chronic implants across 89 animals via pacing threshold measurements or evidence of dislodgement at necropsy. Results: Based on the tine fixation and tissue energy analysis, the tines can easily penetrate the heart. The tines can be safely removed from the myocardium based on the increased tine surface area during retraction. There were no dislodgements observed in the animals and the mean pacing threshold at implant was 0.59 +/− 0.21 V and at termination was 0.65 +/− 0.36 V. The safety factor for dislodgement was determined to be 15X during simulated exercise conditions. Conclusion: The nitinol tine fixation design enabled the implant of a self-contained pacemaker within the right ventricle and was effective in meeting the design requirements. Significance: This fixation technology provides a novel solution to enable the attachment of a transcatheter pacemaker directly within the heart.
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  • 17
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-06-03
    Description: Accurately recovering the hippocampal shapes against rough and noisy segmentations is as challenging as achieving good anatomical correspondence between the individual shapes. To address these issues, we propose a mesh-to-volume registration approach, characterized by a progressive model deformation. Our model implements flexible weighting scheme for model rigidity under a multi-level neighborhood for vertex connectivity. This method induces a large-to-small scale deformation of a template surface to build the pairwise correspondence by minimizing geometric distortion while robustly restoring the individuals' shape characteristics. We evaluated the proposed method's 1) accuracy and robustness in smooth surface reconstruction, 2) sensitivity in detecting significant shape differences between healthy control and disease groups (mild cognitive impairment and Alzheimer's disease), 3) robustness in constructing the anatomical correspondence between individual shape models, and 4) applicability in identifying subtle shape changes in relation to cognitive abilities in a healthy population. We compared the performance of the proposed method with other well-known methods—SPHARM-PDM, ShapeWorks and LDDMM volume registration with template injection—using various metrics of shape similarity, surface roughness, volume, and shape deformity. The experimental results showed that the proposed method generated smooth surfaces with less volume differences and better shape similarity to input volumes than others. The statistical analyses with clinical variables also showed that it was sensitive in detecting subtle shape changes of hippocampus.
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  • 18
    Publication Date: 2015-06-03
    Description: We propose a conditional random field (CRF) based classifier for segmentation of small enhanced pathologies. Specifically, we develop a temporal hierarchical adaptive texture CRF (THAT-CRF) and apply it to the challenging problem of gad enhancing lesion segmentation in brain MRI of patients with multiple sclerosis. In this context, the presence of many nonlesion enhancements (such as blood vessels) renders the problem more difficult. In addition to voxel-wise features, the framework exploits multiple higher order textures to discriminate the true lesional enhancements from the pool of other enhancements. Since lesional enhancements show more variation over time as compared to the nonlesional ones, we incorporate temporal texture analysis in order to study the textures of enhanced candidates over time. The parameters of the THAT-CRF model are learned based on 2380 scans from a multi-center clinical trial. The effect of different components of the model is extensively evaluated on 120 scans from a separate multi-center clinical trial. The incorporation of the temporal textures results in a general decrease of the false discovery rate. Specifically, THAT-CRF achieves overall sensitivity of 95% along with false discovery rate of 20% and average false positive count of 0.5 lesions per scan. The sensitivity of the temporal method to the trained time interval is further investigated on five different intervals of 69 patients. Moreover, superior performance is achieved by the reviewed labelings of our model compared to the fully manual labeling when applied to the context of separating different treatment arms in a real clinical trial.
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  • 19
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-06-03
    Description: We present a novel general-purpose compression method for tomographic images, termed 3D adaptive sparse representation based compression (3D-ASRC). In this paper, we focus on applications of 3D-ASRC for the compression of ophthalmic 3D optical coherence tomography (OCT) images. The 3D-ASRC algorithm exploits correlations among adjacent OCT images to improve compression performance, yet is sensitive to preserving their differences. Due to the inherent denoising mechanism of the sparsity based 3D-ASRC, the quality of the compressed images are often better than the raw images they are based on. Experiments on clinical-grade retinal OCT images demonstrate the superiority of the proposed 3D-ASRC over other well-known compression methods.
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  • 20
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-06-03
    Description: Accurate segmentation is usually crucial in transrectal ultrasound (TRUS) image based prostate diagnosis; however, it is always hampered by heavy speckles. Contrary to the traditional view that speckles are adverse to segmentation, we exploit intrinsic properties induced by speckles to facilitate the task, based on the observations that sizes and orientations of speckles provide salient cues to determine the prostate boundary. Since the speckle orientation changes in accordance with a statistical prior rule, rotation-invariant texture feature is extracted along the orientations revealed by the rule. To address the problem of feature changes due to different speckle sizes, TRUS images are split into several arc-like strips. In each strip, every individual feature vector is sparsely represented, and representation residuals are obtained. The residuals, along with the spatial coherence inherited from biological tissues, are combined to segment the prostate preliminarily via graph cuts. After that, the segmentation is fine-tuned by a novel level sets model, which integrates 1) the prostate shape prior, 2) dark-to-light intensity transition near the prostate boundary, and 3) the texture feature just obtained. The proposed method is validated on two 2-D image datasets obtained from two different sonographic imaging systems, with the mean absolute distance on the mid gland images only $1.06pm 0.53~{hbox {mm}}$ and $1.25pm 0.77~{hbox {mm}}$ , respectively. The method is also extended to segment apex and base images, producing competitive results over the state of the art.
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  • 21
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-18
    Description: Presents a listing of the handling editors for this issue of the publication.
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  • 22
    Publication Date: 2015-09-18
    Description: Presents corrections to the article, ???Learning to detect vocal hyperfunction from ambulatory neck-surface acceleration features: Initial results for vocal fold nodules,??? (Ghassemi, M., et al), IEEE Trans. Biomed. Eng., vol. 61, no. 6, pp. 1668???1675, Jun. 2014.
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  • 23
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: This paper considers the problem of emitter location in the presence of an adversary able to inject false information, where both the viewpoints of the adversary and locating network are considered. We begin by developing adversary strategies, which focus on degrading and redirecting the locating network. The locating network uses the time difference of arrival (TDOA) method and estimates the emitter location using both nonlinear least squares (LS) and the robust least median squares (LMS). Specifically, we determine the false sensor position the adversary should inject that maximally impacts the locating network by 1) minimizing the network???s accuracy, and 2) redirecting the network???s emitter location estimate. Similarly, we formulate a network???s strategy for detecting the adversary???s injection and develop a detector able to determine its presence under both adversary strategies. We present both theoretical and numerical results illustrating the effectiveness of the developed strategies.
    Print ISSN: 0018-9251
    Electronic ISSN: 1557-9603
    Topics: Electrical Engineering, Measurement and Control Technology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 24
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    Publication Date: 2015-09-29
    Description: Delay/disruption tolerant networking (DTN) offers a solution to communications in ???challenged??? networks. Some work has been seen in evaluating the performance of DTN protocols based on simulated or emulated file transfer experiments. However, there is a need for a model of the performance of the DTN Licklider transmission protocol (LTP), which particularly targets reliable data transmission in deep space. In this paper, we present a performance model of LTP-based DTN data transmission in challenging communications characterized by extremely long signal propagation delay, lengthy link disruptions, and highly lossy channels that are typical of deep-space links. The model is verified by file-transfer experiments using a PC-based testbed.
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  • 25
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    Publication Date: 2015-09-29
    Description: Modeling of the dynamics and disturbances and designing of the precise formation controller are two major problems for the inner-formation flying system (IFFS). This paper introduces a nonlinear, nonautonomous formation dynamics model for IFFS in a general elliptic orbit. This model integrates the newly developed formation dynamics and the detailed disturbance models, including atmospheric drag, solar radiation pressure, and J2 effects. Furthermore, this paper establishes a coupled self-gravitational attraction model for IFFS. After considering such a comprehensive dynamics model, the precise formation control problem of IFFS is researched in detail. By referring to the averaging system, Hurwitz matrix, Lyapunov stability theorem, Matrosov???s theory, and Barbalat???s lemma as preliminaries, four possible controllers are designed, i.e., feedback-linearization plus proportional-derivative (PD) controller, Lyapunov-based controller, virtual potential-based controller, and velocity-free virtual potential-based controller. These controllers are all analyzed by the corresponding stability theories. Some simulations are carried out to testify these controllers, and the results show the effectiveness. By comparing the convergence time and fuel consumption, the velocity-free virtual potential-based controller is proven to be a more advantageous controller.
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  • 26
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: The fuel-optimal control problem of soft landing becomes a significant challenge due to the highly irregular gravitational field of an asteroid. An indirect method is used to deal with this fuel-optimal control problem. The difficult bang-bang control problem caused by the indirect method is solved through an improved fast homotopic approach. To validate the advanced homotopic method, the landing site is selected in a region where the gravitational field is especially irregular. The results show that this method is effective for the fuel-optimal control problem in an irregular gravitational field. Moreover, the trajectory designed with the fuel-optimal control is taken as a nominal descent trajectory for a sliding mode control. Monte Carlo simulations show that the desired soft landing can be achieved by tracking the fuel-optimal trajectory.
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  • 27
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: In this paper, a novel framework of sparse kernel learning for support vector data description (SVDD) based anomaly detection is presented. By introducing 0-1 control variables to original features in the input space, sparse feature selection for anomaly detection is modeled as a mixed integer programming problem. Due to the prohibitively high computational complexity, it is relaxed into a quadratically constrained linear programming (QCLP) problem. The QCLP problem can then be practically solved by using an iterative optimization method, in which multiple subsets of features are iteratively found as opposed to a single subset. However, when a nonlinear kernel such as Gaussian radial basis function kernel, associated with an infinite-dimensional reproducing kernel Hilbert space (RKHS) is used in the QCLP-based iterative optimization, it is impractical to find optimal subsets of features due to a large number of possible combinations of the original features. To tackle this issue, a feature map called the empirical kernel map, which maps data points in the input space into a finite space called the empirical kernel feature space (EKFS), is used in the proposed work. The QCLP-based iterative optimization problem is solved in the EKFS instead of in the input space or the RKHS. This is possible because the geometrical properties of the EKFS and the corresponding RKHS remain the same. Now, an explicit nonlinear exploitation of the data in a finite EKFS is achievable, which results in optimal feature ranking. Comprehensive experimental results on three hyperspectral images and several machine learning datasets show that our proposed method can provide improved performance over the current state-of-the-art techniques.
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  • 28
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: This paper deals with the swath acquisition planning problem for multisatellite Earth observation missions. Given a set of satellites and a mission time frame, the problem we solve consists of selecting a set of acquisitions from the satellites in order to cover a given region of interest during the requested time frame, optimizing a certain objective function.We show that the planning problem can be modeled as a set covering problem, using basic tools of mathematical programming. The formulation of the model requires the solution of a complex computational geometry problem, and therefore the use of heuristics and metaheuristics applies. In this paper, we discuss the efficiency of the constructive phase of a greedy randomized adaptive search procedure algorithm. Computational results comparing the heuristic algorithms with the exact approach are presented.
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  • 29
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: This paper proposes an efficient method to classify inverse synthetic aperture radar (ISAR) images. The proposed method achieves invariance to translation and rotation of ISAR images by using two-dimensional (2D) Fourier transform (FT) of ISAR images, polar mapping of the 2D FT image, and a simple nearest-neighbor classifier. In simulations using ISAR images measured in a compact range, the proposed method yielded high classification ratios with small-sized data regardless of the location of the rotation center, whereas the existing method was very sensitive to the location of it.
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  • 30
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: A method for fusing synthetic aperture radar (SAR) images with optical aerial images is presented. This is done in a navigation framework, in which the absolute position and orientation of the flying platform, as computed from the inertial navigation system, is corrected based on the aerial image coordinates taken as ground truth. The method is suitable for new low-price SAR systems for small unmanned vehicles. The primary application is surveillance, and to some extent it can be applied to remote sensing, where the SAR image provides complementary information by revealing reflectivity to microwave frequencies. The method is based on first applying an edge detection algorithm to the images and then optimising the most important navigation states by matching the two binary images. To get a measure of the estimation uncertainty, we embed the optimisation in a least squares framework, in which an explicit method to estimate the (relative) size of the errors is presented. The performance is demonstrated on real SAR and aerial images, leading to an error of only a few pixels (around 4 m in our case), which is a quite satisfactory performance for applications like surveillance and navigation.
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  • 31
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: This paper presents a sensor-control method for choosing the best next state of the sensors that provide accurate estimation results in a multitarget tracking application. The proposed solution is formulated for a multi-Bernoulli filter and works via minimization of a new estimation-error-based cost function. Simulation results demonstrate that the proposed method can outperform the state-of-the-art methods in terms of computation time and robustness to clutter while delivering similar accuracy.
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  • 32
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: The Kalman filter has always been applied to enhance the estimation of inertial measurement unit errors and to improve estimation accuracy of navigation states under practical conditions. Therefore, understanding the behaviors and limitations of optimal estimation of the navigation states is instructive and of great importance. In order to provide comprehensive information about the observability and convergence rapidity of the navigation states when implementing a Kalman filter, the basic properties of intuitive linear-algebraic characterizations of stochastic observability will be intensively investigated in this study. We have extended the utilization of the analytic stochastic observability approach for analytic optimization of strapdown inertial navigation systems multiposition stationary alignment. The advantage of analytic explicit formulation of convergence rapidity of the implemented Kalman filter by stochastic observability approach is demonstrated. Compared to numerical simulation methods, the proposed stochastic observability approach can provide analysts with much more analytic information.
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  • 33
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: Localization of persons that are hidden behind a corner is important in various security situations when the first responders should not be exposed to any threat. This article demonstrates the feasibility of an ultrawideband multipath-exploitation radar for localization in such scenarios. The approach utilizes multibounce echoes of electromagnetic waves that are scattered by the closest person situated behind a corner. We assume that the person does not carry any tag and does not cooperate with the localization system. The multibounce echoes are reflected and diffracted by the surroundings and make the hidden person visible to an operator that is behind the corner. The location estimation relies only on single-channel time-of-arrival data. Measured data are first processed by a background subtraction algorithm, which reveals the multipath evoked by the person. The multipath echoes are detected by a parallel threshold-based detector. A simple global nearest-neighbor algorithm is used for tracking detected echoes and improving their range estimates. The obtained range estimates are assigned to different physical propagation paths of the electromagnetic waves. The location of the person is estimated by fusing the information of the antenna location with respect to its surroundings and the assigned range estimates. The proposed approach is experimentally verified in a scenario where data are measured in real time by an ultrawideband sensor. Experimental results demonstrate that, depending on the scenario geometry, a walking or calmly standing person can be localized up to several meters behind the corner.
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  • 34
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: Inverse synthetic aperture radar (ISAR) images can be obtained using digital video broadcasting???terrestrial (DVB-T)???based passive radars. However, television broadcast???transmitted signals offer poor range resolution for imaging purposes, because they have a narrower bandwidth with respect to those transmitted by a dedicated ISAR system. To reach finer range resolutions, signals composed of multiple DVB-T channels are required. Problems arise, however, because DVB-T channels are typically widely separated in the frequency domain. The gaps between channels produce high grating lobes in the image domain when Fourier-based algorithms are used to form the ISAR image. In this paper, compressive sensing theory is investigated to address this problem because of its ability to reconstruct sparse signals by using incomplete measures. By solving an optimization problem under the constraint of signal sparsity, passive ISAR images can be obtained with strongly reduced grating lobes. Both simulation and experimental results are shown to demonstrate the validity of the proposed approach.
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  • 35
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: Mechanically steered scanning radars receive measurements continuously while sweeping the surveillance region. However, most target tracking algorithms, like the multiple hypothesis tracker (MHT) and the joint probabilistic data association (JPDA) techniques, wait for the end of a scan in order to process the measurements and to estimate targets states. This is due to the fundamental assumption of one-to-one association between tracks and measurements and the 360° physical limit of a scan. Associating measurements to initialized tracks and filtering at the end of a complete scan may cause significant delays in target state update. In addition, association may become imperfect due to longer intervals between updates. This issue becomes significant when tracking high-speed targets with low scan rate sensors as in the airborne early warning (AEW) system. In this paper, we present a new dynamic sector processing algorithm using two-dimensional (2-D) assignment for scanning radars that report measurements within the duration of a scan. The full scan is dynamically and adaptively divided into sectors, which could be as small as a single detection, depending on the scanning rate, sparsity of targets, and required target state update speed. Measurement-to-track association, filtering, and target state update are done dynamically while sweeping from one region to another, i.e., continuous track update, limited only by the intermeasurement interval, becomes possible. The proposed algorithm offers low latency while maintaining estimation accuracy in track updates as well as efficient utilization of computational resources compared with standard frame-based tracking algorithms. Experimental results based on rotating radars demonstrate the advantages of the proposed technique.
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  • 36
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: An iterative ESPRIT-like algorithm is devised for direction-of-departure (DOD) and direction-of-arrival (DOA) estimation in multiple-input multiple-output radar. Our proposal can handle identical DODs and DOAs, and provides autopairing of the angle parameters. Furthermore, it is proved that the multiple signal classification methodology cannot identify (MN ??? 1) targets, where M and N are the element numbers in the transmit and receive antennas, respectively. Simulation results are included to evaluate the performance of the proposed algorithm.
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  • 37
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: Multiple-input multiple-output (MIMO) radar imaging suffers from performance degradation under carrier offsets across transmitters and receivers. This paper analyzes the impact of carrier offsets on imaging a sparse target, from the perspective of the MIMO point spread function (PSF). Conditions are established for successful support recovery using orthogonal matching pursuit (OMP), and the performance loss is characterized in terms of l2 distance. A sparse imaging algorithm taking into account the perturbation due to carrier offsets is also proposed, which improves upon the OMP algorithm. Numerical experiments corroborate this analysis.
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  • 38
    Publication Date: 2015-09-29
    Description: Ambiguity functions (AFs) are obtained for a radar using matched illumination (MI) transmit signals for the detection of range-spread targets in the presence of clutter. The transmit signals are adapted to target and interference spectra and are filtered optimally in the receiver; they are designed to maximize signal-to-interference-and-noise ratio (SINR) power ratios at receiver output. In this paper, expressions for processing gains, spread AFs, and Cramer-Rao bounds on range and Doppler estimates are derived based on likelihood functions. Here, for extended targets, AFs resulting from using optimal MI constant envelope waveforms obtained via phase retrieval techniques demonstrate superior resolution characteristics compared with classic linear frequency-modulated (LFM) signals employing optimal pulse compression. For various target and clutter spectral models, simulation results show that optimally filtered MI signals provide significantly enhanced SINR behavior compared with LFM radar signals. Hopefully, these results set the stage for the induction of MI signaling and receive techniques into conventional radar signal processing and pave the way for realization of one methodology for achieving cognition in radar systems.
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  • 39
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: In an effort to improve the channel utilization of a warship combat system (WCS), it is necessary to control and manage the large volume of video traffic by considering a strong self-similarity characteristic. We propose a new video traffic management method for the WCS that smooths the traffic of the closed-circuit television surveillance system (CSS) video and encodes the electro-optical tracking system (EOTS) video with low complexity in real time. First, to achieve global and local traffic smoothing for the CSS video traffic, a proper bandwidth allocation interval and a minimum bandwidth for the CSS video traffic must be determined. Second, due to the increased available bandwidth after traffic smoothing, more elaborate low-delay encoding is accomplished by selecting encoding modes adaptively to compress the EOTS video efficiently with high visual quality. The experimental results demonstrate that the proposed method is able to control the WCS traffic to be as flat as possible and to encode the EOTS video with low delay, even in combat and emergency scenarios. Hence, we show that to migrate to network-centric warfare successfully, the proposed method is much more suitable for the WCS than conventional video traffic management.
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  • 40
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: In this paper, we propose multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) radar with sufficient cyclic prefix (CP), where all OFDM pulses transmitted from different transmitters share the same frequency band and are orthogonal to each other for every subcarrier in the discrete frequency domain. The orthogonality is not affected by time delays from transmitters. Thus, our proposed MIMO OFDM radar has the same range resolution as single transmitter radar and achieves full spatial diversity. Orthogonal designs are used to achieve this orthogonality across the transmitters, with which it is only needed to design OFDM pulses for the first transmitter. We also propose a joint pulse compression and pulse coherent integration for range reconstruction. In order to achieve the optimal signal-to-noise ratio (SNR) for the range reconstruction, we apply the paraunitary filterbank theory to design the OFDM pulses. We then propose a modified iterative clipping and filtering (MICF) algorithm for the designs of OFDM pulses jointly, when other important factors, such as peak-to-average power ratio (PAPR) in time domain, are also considered.With our proposed MIMO OFDM radar, there is no interference for the range reconstruction not only across the transmitters but also across the range cells in a swath called inter-range-cell interference (IRCI) free that is similar to our previously proposed CP-based OFDM radar for single transmitter. Simulations are presented to illustrate our proposed theory and show that the CP-based MIMO OFDM radar outperforms the existing frequency-band shared MIMO radar with polyphase codes and also frequency division MIMO radar.
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  • 41
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: The minimum-variance filter and smoother are generalized to include Poisson-distributed measurement noise components. It is shown that the resulting filtered and smoothed estimates are unbiased. The use of the filter and smoother within expectation-maximization algorithms are described for joint estimation of the signal and Poisson noise intensity. Conditions for the monotonicity and asymptotic convergence of the Poisson intensity iterates are also established. An image restoration example is presented that demonstrates improved estimation performance at low signal-to-noise ratios.
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  • 42
    Publication Date: 2015-09-29
    Description: This paper proposes a new radar/sonar processing architecture that enables a low-rate time-sampling rate while still producing a high-resolution range profile over a narrow range-window. This new architecture generalizes the conventional ???stretch processing??? architecture (which employs linear frequency modulated (LFM) waveforms that suffer from high range-sidelobes), to nonlinear frequency modulated (NLFM) waveforms, which can lower the range-sidelobes without tapering. Computational results demonstrate both the estimation efficacy and the time-sampling efficiency of the proposed scheme.
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  • 43
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: Free-floating manipulators are subject to dynamic singularities that complicate their Cartesian motions and restrict their workspace. In this work, the Cartesian trajectory planning of free-floating manipulators is studied. A methodology is developed in which, for given end-effector trajectories, appropriate initial system configurations are found that result in singularity avoidance during end-effector motion. The method applies to both planar and spatial systems, with and without initial angular momentum, and to any desired end-effector position and attitude trajectories.
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  • 44
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-09-29
    Description: This paper investigates the problem of fusion filtering for a class of networked multisensor fusion systems with multiple uncertainties, including sensor failures, stochastic parameter uncertainties, random observation delays, and packet dropouts. A novel model is proposed to describe the random observation delays and packet dropouts, and a robust optimal fusion filter for the addressed networked multisensor fusion systems is designed using the innovation analysis method. The dimension of the designed filter is the same as that of the original system, which helps to reduce computation cost compared with the augmentation method. Moreover, robust reduced-dimension observation-fusion Kalman filters are proposed to further reduce the computation burden. Note that the designed fusion filter gain matrices can be computed off-line, as they depend only on the upper bounds of random delays and on the occurrence probabilities of delays and sensor failures. Some sufficient conditions are presented for stability and optimality of the designed fusion filters, and a steady-state fusion filter is also given for the networked multisensor fusion systems. Simulations show the effectiveness of the proposed fusion filters.
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  • 45
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-10-27
    Description: Fabricated vessel-mimetic microtubes are essential for delivering sufficient nutrient to engineered composite tissues. In this paper, vascular-like microtubes are engineered by automated assembly of donut-shaped micromodules that embed fibroblast cells. A microrobotic system is set up with dual manipulators of 30-nm positioning resolution under an optical microscope. The system assembles the micromodules by repeated single-step pick-up motions. This process is specifically designed to avoid human interference and ensure high reproducibility for automation. We optimized the single-step motion by calibrating the key parameters (the micromodule dimensions) in a force analysis. The optimal motion achieved a 98% pick-up success rate. The automated repetitive single-step assembly is achieved by an algorithm that acquires the 3-D location and tracks the micromanipulator without being affected by low contrast. The accuracy of the acquired 3-D location was experimentally determined as approximately 1 pixel (2 μm under 4× magnification), and the tracking under different observation conditions is proved effective. Finally, we automatically assembled microtubes at 6 micromodules/min, sufficiently fast for fabricating macroscopic vessel-mimetic substitutes in biological applications.
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  • 46
    Publication Date: 2015-10-27
    Description: Goal: This study tests and validates a new method to remove power line interference from monopolar EMGs detected by multichannel systems: the filtered virtual reference (FVR). FVR is an adaptation of the virtual reference (VR) method, which consists in referencing signals detected by each electrode in a grid to their spatial average. Signals may however be distorted with the VR approach, in particular when the skin region where the detection system is positioned does not cover the entire muscle. Methods: Simulated and experimental EMGs were used to compare the performance of FVR and VR in terms of interference reduction and distortion of monopolar signals referred to a remote reference. Results : Simulated data revealed the monopolar EMG signals processed with FVR were significantly less distorted than those filtered by VR. These results were similarly observed for experimental signals. Moreover, FVR method outperformed VR in removing power line interference when it was distributed unevenly across the signals of the grid. Conclusion: Key results demonstrated that FVR improves the VR method as it reduces interference while preserving the information content of monopolar signals. Significance: Although the actual distribution of motor unit action potential is represented in monopolar EMGs, collecting high quality monopolar signals is challenging. This study presents a possible solution to this issue; FVR provides undistorted monopolar signals with negligible interference and is insensitive to muscle architecture. It is therefore relevant for EMG applications benefiting from a clean monopolar detection (e.g., decomposition, control of prosthetic devices, motor unit number estimation).
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  • 47
    Publication Date: 2015-10-27
    Description: This study concentrates on finite-element-method (FEM)-based electroencephalography (EEG) forward simulation in which the electric potential evoked by neural activity in the brain is to be calculated at the surface of the head. The main advantage of the FEM is that it allows realistic modeling of tissue conductivity inhomogeneity. However, it is not straightforward to apply the classical model of a dipolar source with the FEM, due to its strong singularity and the resulting irregularity. The focus of this study is on comparing different methods to cope with this problem. In particular, we evaluate the accuracy of Whitney (Raviart–Thomas)-type dipole-like source currents compared to two reference dipole modeling methods: the St. Venant and partial integration approach. Common to all these methods is that they enable direct approximation of the potential field utilizing linear basis functions. In the present context, Whitney elements are particularly interesting, as they provide a simple means to model a divergence-conforming primary current vector field satisfying the square integrability condition. Our results show that a Whitney-type source model can provide simulation accuracy comparable to the present reference methods. It can lead to superior accuracy under optimized conditions with respect to both source location and orientation in a tetrahedral mesh. For random source orientations, the St. Venant approach turns out to be the method of choice over the interpolated version of the Whitney model. The overall moderate differences obtained suggest that practical aspects, such as the focality, should be prioritized when choosing a source model.
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  • 48
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-10-27
    Description: This paper presents a wearable vital signs monitor at the ear. The monitor measures the electrocardiogram (ECG), ballistocardiogram (BCG), and photoplethysmogram (PPG) to obtain pre-ejection period (PEP), stroke volume (SV), cardiac output (CO), and pulse transit time (PTT). The ear is demonstrated as a natural anchoring point for the integrated sensing of physiological signals. All three signals measured can be used to obtain heart rate (HR). Combining the ECG and BCG allows for the estimation of the PEP, while combining the BCG and PPG allows for the measurement of PTT. Additionally, the J-wave amplitude of the BCG is correlated with the SV and, when combined with HR, yields CO. Results from a clinical human study on 13 subjects demonstrate this proof-of-concept device.
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  • 49
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-06-13
    Description: Presents the back cover of this issue of the periodical.
    Print ISSN: 0885-8985
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  • 50
    Publication Date: 2015-06-13
    Description: Nonmilitary applications of unmanned air vehicles (UAVs), especially as rescue vehicles to obtain information have increased in recent years. Small UAVs (SUAV) were used in nonmilitary projects, where the focus was on autonomous vehicles; however, microaerial vehicles (MAVs), such as Samarai, make use of radio control, and they were not autonomous vehicles [1]. Autonomous UAVs need sophisticated guidance, control, and navigation systems with conventional aircraft flying processes. Most of current UAVs use ground-station commands for guidance purposes, although autonomous UAVs tend to reduce dependency on ground-station command via autonomous algorithms, such as intelligent methods. Therefore, ground-based air control may not suffice to cover every flying mission. Thus, self-contained, onboard guidance via intelligent methods, such as fuzzy logic, has been considered to achieve this goal. Lockheed Martin???s Intelligent Robotics Laboratory has spent the last 5 years developing an unmanned craft to replicate the air vehicle motion. The idea was based on the motion of maple seed, which whirls softly to the ground after dropping from maple tree. This motion, which is similar to a one-winged helicopter, inspired Lockheed Martin to design a new type of flying vehicles, beneficial in military and nonmilitary surveillance. Maple seeds disperse themselves by auto-rotating passively by using a single wing as they descend from trees, thereby ensuring they are widely scattered. Inspired by these flight concepts, Lockheed Martin Advanced Technology Laboratories developed the Samarai MAV, a 30-cm-radius maple seedlike aircraft that can take off and land vertically and fly laterally, like a helicopter, due to the intrinsic stability of the maple seeds??? nature [2] (Figure 1).
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015-06-13
    Description: Presents the message from the Associate Editor-in-Chief.
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    Publication Date: 2016-07-19
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  • 54
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    Publication Date: 2016-07-19
    Description: Prospective authors are requested to submit new, unpublished manuscripts for inclusion in the upcoming event described in this call for papers.
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  • 55
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    Publication Date: 2016-07-19
    Description: Presents information on forthcoming Engineering Management society conferences.
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  • 56
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-07-19
    Description: Provides a listing of the editors, board members, and current staff for this issue of the publication.
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  • 57
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-07-19
    Description: Provides a listing of board members, committee members, editors, and society officers.
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  • 58
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    Publication Date: 2016-07-19
    Description: This paper presents a method to estimate steady wind and a maneuvering strategy for loitering under a strong, steady wind. The wind estimation uses Global Positioning System velocity only through a novel filter design without airspeed measurement. The wind estimate is then used to guide the aircraft to crab in a direction perpendicular to the wind, thereby avoiding large changes in flight variables if an orbit-type maneuver is attempted. The proposed method is demonstrated through flight tests.
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  • 59
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    Publication Date: 2016-07-19
    Description: We propose biased estimators to find the direction of arrival of emitters present in the mainlobe of a spinning antenna-based electronic intelligence system. The proposed estimators were constructed by using Bayesian techniques and by performing a linear transformation and an affine transformation on the maximum likelihood estimator. From a Monte Carlo simulation and experimental results, we demonstrate that the proposed estimators outperform the limit set by the popular performance benchmark, the Cramer-Rao lower bound.
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  • 60
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    Publication Date: 2016-07-19
    Description: Objective: We present the framework for wearable joint rehabilitation assessment following musculoskeletal injury. We propose a multimodal sensing (i.e., contact based and airborne measurement of joint acoustic emission) system for at-home monitoring. Methods: We used three types of microphones—electret, MEMS, and piezoelectric film microphones—to obtain joint sounds in healthy collegiate athletes during unloaded flexion/extension, and we evaluated the robustness of each microphone's measurements via: 1) signal quality and 2) within-day consistency. Results: First, air microphones acquired higher quality signals than contact microphones (signal-to-noise-and-interference ratio of 11.7 and 12.4 dB for electret and MEMS, respectively, versus 8.4 dB for piezoelectric). Furthermore, air microphones measured similar acoustic signatures on the skin and 5 cm off the skin (∼4.5× smaller amplitude). Second, the main acoustic event during repetitive motions occurred at consistent joint angles (intra-class correlation coefficient ICC(1, 1) = 0.94 and ICC(1, k) = 0.99). Additionally, we found that this angular location was similar between right and left legs, with asymmetry observed in only a few individuals. Conclusion: We recommend using air microphones for wearable joint sound sensing; for practical implementation of contact microphones in a wearable device, interface noise must be reduced. Importantly, we show that airborne signals can be measured consistently and that healthy left and right knees often produce a similar pattern in acoustic emissions. Significance: These proposed methods have the potential for enabling knee joint acoustics measurement outside the clinic/lab and permitting long-term monitoring of knee health for patients rehabilitating an acute knee joint injury.
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  • 61
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    Publication Date: 2016-07-19
    Description: A new method was proposed for chirp signal detection and estimation built on the frame-based fast Fourier transform (FFT). The proposed method uses the peak frequency difference between FFT frames to detect a chirp signal and estimate chirp rate. This approach differs from conventional methods and is easy to implement. It generates more accurate chirp rate estimation especially under a low signal-to-noise ratio. Simulation and experimental data are used to verify the proposed methods.
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  • 62
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    Publication Date: 2016-07-19
    Description: As telehealth applications emerge, the need for accurate and reliable biosignal quality indices has increased. One typical modality used in remote patient monitoring is the electrocardiogram (ECG), which is inherently susceptible to several different noise sources, including environmental (e.g., powerline interference), experimental (e.g., movement artifacts), and physiological (e.g., muscle and breathing artifacts). Accurate measurement of ECG quality can allow for automated decision support systems to make intelligent decisions about patient conditions. This is particularly true for in-home monitoring applications, where the patient is mobile and the ECG signal can be severely corrupted by movement artifacts. In this paper, we propose an innovative ECG quality index based on the so-called modulation spectral signal representation. The representation quantifies the rate of change of ECG spectral components, which are shown to be different from the rate of change of typical ECG noise sources. The proposed modulation spectral-based quality index, MS-QI, was tested on 1) synthetic ECG signals corrupted by varying levels of noise, 2) single-lead recorded data using the Hexoskin garment during three activity levels (sitting, walking, running), 3) 12-lead recorded data using conventional ECG machines (Computing in Cardiology 2011 dataset), and 4) two-lead ambulatory ECG recorded from arrhythmia patients (MIT-BIH Arrhythmia Database). Experimental results showed the proposed index outperforming two conventional benchmark quality measures, particularly in the scenarios involving recorded data in real-world environments.
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  • 63
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    Publication Date: 2016-07-19
    Description: Platelet-rich plasma (PRP) is a volume of autologous plasma that has a higher platelet concentration above baseline. It has already been approved as a new therapeutic modality and investigated in clinics, such as bone repair and regeneration, and oral surgery, with low cost-effectiveness ratio. At present, PRP is mostly prepared using a centrifuge. However, this method has several shortcomings, such as long preparation time (30 min), complexity in operation, and contamination of red blood cells (RBCs). In this paper, a new PRP preparation approach was proposed and tested. Ultrasound waves (4.5 MHz) generated from piezoelectric ceramics can establish standing waves inside a syringe filled with the whole blood. Subsequently, RBCs would accumulate at the locations of pressure nodes in response to acoustic radiation force, and the formed clusters would have a high speed of sedimentation. It is found that the PRP prepared by the proposed device can achieve higher platelet concentration and less RBCs contamination than a commercial centrifugal device, but similar growth factor (i.e., PDGF-ββ). In addition, the sedimentation process under centrifugation and sonication was simulated using the Mason–Weaver equation and compared with each other to illustrate the differences between these two technologies and to optimize the design in the future. Altogether, ultrasound method is an effective method of PRP preparation with comparable outcomes as the commercially available centrifugal products.
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  • 64
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    Publication Date: 2016-07-19
    Description: The quasimaximum likelihood (QML) estimator of polynomial-phase signals (PPSs) is based on the maximization of the short-time Fourier transform and suffers from aliasing when signals are sampled below the Nyquist sampling rate. In this paper, a phase unwrapping procedure has been proposed as an additional step in the QML to estimate parameters of such signals. Statistical study has shown excellent performance of the proposed approach.
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  • 65
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    Publication Date: 2016-07-19
    Description: A new wireless sensor was designed, fabricated, and applied for in situ monitoring of tensile force at a wound site. The sensor was comprised of a thin strip of magnetoelastic material with its two ends connected to suture threads for securing the sensor across a wound repair site. Since the sensor was remotely interrogated by applying an ac magnetic field and capturing the resulting magnetic field, it did not require direct wire connections to an external device or internal battery for long-term use. Due to its magnetoelastic property, the application of a tensile force changed the magnetic permeability of the sensor, altering the amplitude of the measured magnetic field. This study presents two sensor designs: one for high and one for low-force ranges. A sensor was fabricated by directly adhering the magnetoelastic strip to the suture. This sensor showed good sensitivity at low force, but its response saturated at about 1.5 N. To monitor high tensile force, the magnetoelastic strip was attached to a metal strip for load sharing. The suture thread was attached to the both ends of the metal strip so only a fraction of the applied force was directed to the sensor, allowing it to exhibit good sensitivity even at 44.5 N. The sensor was applied to two ex vivo models: a sutured section of porcine skin and a whitetail deer Achilles tendon. The results demonstrate the potential for in vivo force monitoring at a wound repair site.
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  • 66
    Publication Date: 2016-07-19
    Description: This study presents a precise way to detect the third ( $S_{3}$ ) heart sound, which is recognized as an important indication of heart failure, based on nonlinear single decomposition and time–frequency localization. The detection of the $S_{3}$ is obscured due to its significantly low energy and frequency. Even more, the detected $S_{3}$ may be misunderstood as an abnormal second heart sound with a fixed split, which was not addressed in the literature. To detect such $S_{3}$ , the Hilbert vibration decomposition method is applied to decompose the heart sound into a certain number of subcomponents while intactly preserving the phase information. Thus, the time information of all of the decomposed components are unchanged, which further expedites the identification and localization of any module/section of a signal properly. Next, the proposed localization step is applied to the decomposed subcomponents by using smoothed pseudo Wigner–Ville distribution followed by the reassignment method. Finally, based on the positional information, the $S_{3}$ is distinguished and confirmed by measuring time delays between the $S_{2}$ and $S_{3}$ . In total, 82 sets of cardiac cycles collected from different databases including Texas Heart Institute database are examined for evaluation of the proposed method. The result analysis shows that the proposed method can detect the $S_{3}$ correctly, even when the - ormalized temporal energy of $S_{3}$ is larger than 0.16, and the frequency of those is larger than 34 Hz. In a performance analysis, the proposed method demonstrates that the accuracy rate of $S_{3}$ detection is as high as 93.9%, which is significantly higher compared with the other methods. Such findings prove the robustness of the proposed idea for detecting substantially low-energized $S_{3}$ .
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  • 67
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    Publication Date: 2016-07-19
    Description: Electromagnetic (EM) tracking systems are highly susceptible to field distortion. The interference can cause measurement errors up to a few centimeters in clinical environments, which limits the reliability of these systems. Unless corrected for, this measurement error imperils the success of clinical procedures. It is therefore fundamental to dynamically calibrate EM tracking systems and compensate for measurement error caused by field distorting objects commonly present in clinical environments. We propose to combine a motion model with observations of redundant EM sensors and compensate for field distortions in real time. We employ a simultaneous localization and mapping technique to accurately estimate the pose of the tracked instrument while creating the field distortion map. We conducted experiments with six degrees-of-freedom motions in the presence of field distorting objects in research and clinical environments. We applied our approach to improve the EM tracking accuracy and compared our results to a conventional sensor fusion technique. Using our approach, the maximum tracking error was reduced by 67% for position measurements and by 64% for orientation measurements. Currently, clinical applications of EM trackers are hampered by the adverse distortion effects. Our approach introduces a novel method for dynamic field distortion compensation, independent from preoperative calibrations or external tracking devices, and enables reliable EM navigation for potential applications.
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  • 68
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    Publication Date: 2016-07-19
    Description: A feasibility study on a new technique capable of monitoring localized sweat rate is explored in this paper. Wearable devices commonly used in clinical practice for sweat sampling (i.e., Macroducts) were positioned on the body of an athlete whose sweat rate was then monitored during cycling sessions. The position at which the sweat fills the Macroduct was indicated by a contrasting marker and captured via a series of time-stamped photos or a video recording of the device during an exercise period. Given that the time of each captured image/frame is known (either through time stamp on photos or the constant frame rate of the video capture), it was, therefore, possible to estimate the sweat flow rate through a simple calibration model. The importance of gathering such valuable information is described, together with the results from a number of exercise trials to investigate the viability of this approach.
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  • 69
    Publication Date: 2016-07-19
    Description: Objective: A novel high-precision approach [lifetime-decomposition measurement (LTDM)] for the assessment of the glomerular filtration rate (GFR) based on clearance measurements of exogenous filtration marker. Methods: The time-correlated single photon counting (TCSPC) acquisition in combination with a new decomposition method allows the separation of signal and background from transcutaneous measurements of GFR. Results: The performance of LTDM is compared versus the commercially available NIC-kidney patch-based system for transcutaneous GFR measurement. Measurements are performed in awake Sprague Dawley (SD) rats. Using the standard concentration required for the NIC-kidney system [7-mg/100-g body weight (b.w.) FITC-Sinistrin] as reference, the mean difference (bias) of the elimination curves GFR between LTDM and NIC-kidney was 4.8%. On the same animal and same day, the capability of LTDM to measure GFR with a FITC-Sinistrin dose reduced by a factor of 200 (35-μg/100-g b.w.) was tested as well. The mean differences (half lives with low dose using LTDM compared with those using first, the NIC-Kidney system and its standard concentration, and second, LTDM with the same concentration as for the NIC-Kidney system) were 3.4% and 4.5%, respectively. Conclusion: We demonstrate that with the LTDM strategy substantial reductions in marker concentrations are possible at the same level of accuracy. Significance: LTDM aims to resolve the issue of the currently necessary large doses of fluorescence tracer required for transcutaneous GFR measurement. Due to substantially less influences from autofluorescence and artifacts, the proposed method outperforms other existing techniques for accurate percutaneous organ function measurement.
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  • 70
    Publication Date: 2016-07-19
    Description: Classic brain–machine interface (BMI) approaches decode neural signals from the brain responsible for achieving specific motor movements, which subsequently command prosthetic devices. Brain activities adaptively change during the control of the neuroprosthesis in BMIs, where the alteration of the preferred direction and the modulation of the gain depth are observed. The static neural tuning models have been limited by fixed codes, resulting in a decay of decoding performance over the course of the movement and subsequent instability in motor performance. To achieve stable performance, we propose a dual sequential Monte Carlo adaptive point process method, which models and decodes the gradually changing modulation depth of individual neuron over the course of a movement. We use multichannel neural spike trains from the primary motor cortex of a monkey trained to perform a target pursuit task using a joystick. Our results show that our computational approach successfully tracks the neural modulation depth over time with better goodness-of-fit than classic static neural tuning models, resulting in smaller errors between the true kinematics and the estimations in both simulated and real data. Our novel decoding approach suggests that the brain may employ such strategies to achieve stable motor output, i.e., plastic neural tuning is a feature of neural systems. BMI users may benefit from this adaptive algorithm to achieve more complex and controlled movement outcomes.
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  • 71
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  • 72
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  • 73
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-07-19
    Description: Prospective authors are requested to submit new, unpublished manuscripts for inclusion in the upcoming event described in this call for papers.
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  • 74
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    Publication Date: 2016-07-22
    Description: Objective: This work evaluates current 3-D image registration tools on clinically acquired abdominal computed tomography (CT) scans. Methods: Thirteen abdominal organs were manually labeled on a set of 100 CT images, and the 100 labeled images (i.e., atlases) were pairwise registered based on intensity information with six registration tools (FSL, ANTS-CC, ANTS-QUICK-MI, IRTK, NIFTYREG, and DEEDS). The Dice similarity coefficient (DSC), mean surface distance, and Hausdorff distance were calculated on the registered organs individually. Permutation tests and indifference-zone ranking were performed to examine the statistical and practical significance, respectively. Results: The results suggest that DEEDS yielded the best registration performance. However, due to the overall low DSC values, and substantial portion of low-performing outliers, great care must be taken when image registration is used for local interpretation of abdominal CT. Conclusion: There is substantial room for improvement in image registration for abdominal CT. Significance: All data and source code are available so that innovations in registration can be directly compared with the current generation of tools without excessive duplication of effort.
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  • 75
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    Publication Date: 2016-07-22
    Description: Goal : In K-edge tomographic imaging with photon counting detectors, the energy window width of photon counting detectors significantly affects the signal-to-noise ratio (SNR) of measured intensity data and the contrast-to-noise ratio (CNR) of reconstructed images. In this paper, we present an optimization method to determine an optimal window width around a K-edge for optimal SNR and CNR. Methods : An objective function is designed to describe SNR of the projection data based on the Poisson distribution of detected X-ray photons. Then, a univariate optimization method is applied to obtain an X-ray energy window width. Results : Numerical simulations are performed to evaluate the proposed method, and the results show that the optimal energy window width obtained from the proposed method produces not only optimal SNR data in the projection domain but also optimal CNR values in the image domain. Conclusion : The proposed method in the projection domain can determine an optimal energy window width for X-ray photon counting imaging, and achieve optimality in both projection and image domains. Significance : Our study provides a practical way to determine the optimal energy window width of photon counting detectors, which helps improve contrast resolution for X-ray K-edge tomographic imaging.
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  • 76
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    Publication Date: 2016-07-22
    Description: Objective: The propagation of electrophysiological activity measured by multichannel devices could have significant clinical implications. Gastric slow waves normally propagate along longitudinal paths that are evident in recordings of serosal potentials and transcutaneous magnetic fields. We employed a realistic model of gastric slow wave activity to simulate the transabdominal magnetogastrogram (MGG) recorded in a multichannel biomagnetometer and to determine characteristics of electrophysiological propagation from MGG measurements. Methods: Using MGG simulations of slow wave sources in a realistic abdomen (both superficial and deep sources) and in a horizontally-layered volume conductor, we compared two analytic methods (second-order blind identification, SOBI and surface current density, SCD) that allow quantitative characterization of slow wave propagation. We also evaluated the performance of the methods with simulated experimental noise. The methods were also validated in an experimental animal model. Results: Mean square errors in position estimates were within 2 cm of the correct position, and average propagation velocities within 2 mm/s of the actual velocities. SOBI propagation analysis outperformed the SCD method for dipoles in the superficial and horizontal layer models with and without additive noise. The SCD method gave better estimates for deep sources, but did not handle additive noise as well as SOBI. Conclusion: SOBI-MGG and SCD-MGG were used to quantify slow wave propagation in a realistic abdomen model of gastric electrical activity. Significance: These methods could be generalized to any propagating electrophysiological activity detected by multichannel sensor arrays.
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  • 77
    Publication Date: 2016-07-22
    Description:   Goal : This study aims at a systematic assessment of five computational models of a birdcage coil for magnetic resonance imaging (MRI) with respect to accuracy and computational cost. Methods : The models were implemented using the same geometrical model and numerical algorithm, but different driving methods (i.e., coil “defeaturing”). The defeatured models were labeled as: specific ( S2 ), generic ( G32 , G16 ), and hybrid ( H16, $hbox{H16}_{{rm fr}text{-}{rm forced}}$ ). The accuracy of the models was evaluated using the “symmetric mean absolute percentage error” (“SMAPE”), by comparison with measurements in terms of frequency response, as well as electric ( $|{vec E}|$ ) and magnetic ( $| {vec B} |$ ) field magnitude. Results : All the models computed the $| {vec B} |$ within 35% of the measurements, only the S2 , G32, and H16 were able to accurately model the $|{vec E}|$ inside the phantom with a maximum SMAPE of 16%. Outside the phantom, only the S2 showed a SMAPE lower than 11%. Conclusions : Results showed that assessing the accuracy of $| {vec B} |$ based only on comparison along the central longitudinal line of the coil can be misleading. Generic or hybrid coils — when properly modeling the currents along the rings/rungs — were sufficient to accur- tely reproduce the fields inside a phantom while a specific model was needed to accurately model $|{vec E}|$ in the space between coil and phantom. Significance : Computational modeling of birdcage body coils is extensively used in the evaluation of radiofrequency-induced heating during MRI. Experimental validation of numerical models is needed to determine if a model is an accurate representation of a physical coil.
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  • 78
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    Publication Date: 2016-07-22
    Description: Objective: The objective of this research was to develop a bioimpedance platform for monitoring fluid volume in residual limbs of people with trans-tibial limb loss using prostheses. Methods: A customized multifrequency current stimulus profile was sent to thin flat electrodes positioned on the thigh and distal residual limb. The applied current signal and sensed voltage signals from four pairs of electrodes located on the anterior and posterior surfaces were demodulated into resistive and reactive components. An established electrical model (Cole) and segmental limb geometry model were used to convert results to extracellular and intracellular fluid volumes. Bench tests and testing on amputee participants were conducted to optimize the stimulus profile and electrode design and layout. Results: The proximal current injection electrode needed to be at least 25 cm from the proximal voltage sensing electrode. A thin layer of hydrogel needed to be present during testing to ensure good electrical coupling. Using a burst duration of 2.0 ms, intermission interval of 100 μs, and sampling delay of 10 μs at each of 24 frequencies except 5 kHz, which required a 200-μs sampling delay, the system achieved a sampling rate of 19.7 Hz. Conclusion: The designed bioimpedance platform allowed system settings and electrode layouts and positions to be optimized for amputee limb fluid volume measurement. Significance: The system will be useful toward identifying and ranking prosthetic design features and participant characteristics that impact residual limb fluid volume.
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  • 79
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    Publication Date: 2016-07-22
    Description: Surface electromyography (sEMG) has been the predominant method for sensing electrical activity for a number of applications involving muscle–computer interfaces, including myoelectric control of prostheses and rehabilitation robots. Ultrasound imaging for sensing mechanical deformation of functional muscle compartments can overcome several limitations of sEMG, including the inability to differentiate between deep contiguous muscle compartments, low signal-to-noise ratio, and lack of a robust graded signal. The objective of this study was to evaluate the feasibility of real-time graded control using a computationally efficient method to differentiate between complex hand motions based on ultrasound imaging of forearm muscles. Dynamic ultrasound images of the forearm muscles were obtained from six able-bodied volunteers and analyzed to map muscle activity based on the deformation of the contracting muscles during different hand motions. Each participant performed 15 different hand motions, including digit flexion, different grips (i.e., power grasp and pinch grip), and grips in combination with wrist pronation. During the training phase, we generated a database of activity patterns corresponding to different hand motions for each participant. During the testing phase, novel activity patterns were classified using a nearest neighbor classification algorithm based on that database. The average classification accuracy was 91%. Real-time image-based control of a virtual hand showed an average classification accuracy of 92%. Our results demonstrate the feasibility of using ultrasound imaging as a robust muscle–computer interface. Potential clinical applications include control of multiarticulated prosthetic hands, stroke rehabilitation, and fundamental investigations of motor control and biomechanics.
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  • 80
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    Publication Date: 2016-07-22
    Description: Presents the introductory editorial for this issue of the publication.
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  • 81
    Publication Date: 2016-07-22
    Description: We have been developing an automated cardiovascular drug infusion system for simultaneous control of arterial pressure (AP), cardiac output (CO), and left atrial pressure (P LA ) in decompensated heart failure (HF). In our prototype system, CO and P LA were measured invasively through thoracotomy. Furthermore, the control logic inevitably required use of inotropes to improve hemodynamics, which was not in line with clinical HF guidelines. The goal of this study was to solve these problems and develop a clinically feasible system. We integrated to the system minimally invasive monitors of CO and pulmonary capillary wedge pressure (PCWP, surrogates for P LA ) that we developed recently. We also redesigned the control logic to reduce the use of inotrope. We applied the newly developed system to nine dogs with decompensated HF. Once activated, our system started to control the infusion of vasodilator and diuretics in all the animals. Inotrope was not infused in three animals, and infused at minimal doses in six animals that were intolerant of vasodilator infusion alone. Within 50 min, our system controlled AP, CO, and PCWP to their respective targets accurately. Pulmonary artery catheterization confirmed optimization of hemodynamics (AP, from 98 ± 4 to 74 ± 11 mmHg; CO, from 2.2 ± 0.5 to 2.9 ± 0.3 L·min −1 ·m −2 ; PCWP, from 27.0 ± 6.6 to 13.8 ± 3.0 mmHg). In a minimally invasive setting while reducing the use of inotrope, our system succeeded in automatically optimizing the overall hemodynamics in canine models of HF. The present results pave the way for clinical application of our automated drug infusion system.
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  • 82
    Publication Date: 2016-07-22
    Description: Image registration is a key problem in a variety of applications, such as computer vision, medical image processing, pattern recognition, etc., while the application of registration is limited by time consumption and the accuracy in the case of large pose differences. Aimed at these two kinds of problems, we propose a fast rotation-free feature-based rigid registration method based on our proposed accelerated-NSIFT and GMM registration-based parallel optimization (PO-GMMREG). Our method is accelerated by using the GPU/CUDA programming and preserving only the location information without constructing the descriptor of each interest point, while its robustness to missing correspondences and outliers is improved by converting the interest point matching to Gaussian mixture model alignment. The accuracy in the case of large pose differences is settled by our proposed PO-GMMREG algorithm by constructing a set of initial transformations. Experimental results demonstrate that our proposed algorithm can fast rigidly register 3-D medical images and is reliable for aligning 3-D scans even when they exhibit a poor initialization.
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  • 83
    Publication Date: 2016-07-22
    Description: Spare parts support services have received increasing management attention due to the growing number of critical systems in many business sectors. In this paper, we examine an integrated system design approach to customize spare parts support services based on response time with inventory pooling strategies. To provide customized services that meet user requirements for spare part response time, we depart from the traditional spare parts management and develop a systematic approach to design service parts support services based on axiomatic design theory. In particular, we focus on pricing discrimination decisions in service parts contracts for two-tier users under a mechanism design framework. Distinguishing between users of next-day and same-day contracts for service parts operations, we further evaluate the effect of various inventory pool structures with reserve strategies through a simulation model for the objective of cost minimization. These analytical results of this new approach provide guidance for managers in customizing spare parts support services with the holistic consideration of pricing scheme, response time, and inventory policy.
    Print ISSN: 0018-9391
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  • 84
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-07-22
    Description: This paper considers an auto parts supplier who receives order release updates from its customers and revises its production plan for future periods on a weekly basis. The inaccuracy of the order releases causes significant costs in the form of premium expedited transportation, production overtime, and excess inventory. This setting provides a rich context for studying order release variance, because the supply chain has adopted a just-in-time (JIT) approach where ideal inventory levels are kept at zero. This leads to a high reliance on order release accuracy in order to manage production quantities. This paper presents an optimization model that extends previous approaches focused on optimizing production plans to the JIT setting. Furthermore, based on real order release information provided to the supplier, two simple adjustment heuristic methods are developed. The performances of these approaches are compared with relying solely on order releases received from the customers. The simple median-based adjustment heuristic performs the best of all the approaches. Implications of the analysis are also discussed.
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  • 85
    Publication Date: 2016-07-22
    Description: This paper considers a manufacturer who outsources the production of a product to multiple competing suppliers, who differ in their cost structures and in their capabilities for producing high-quality products. The manufacturer must design the sourcing process to ensure that the selected supplier has sufficient quality capability, while encouraging competition among the suppliers. We develop and analyze a mathematical model of performance-based contracting, a sourcing method that is appropriate when the manufacturer has imperfect information regarding the suppliers’ costs and capabilities. We compare the performance of performance-based contracting with that of a two-stage sourcing process, an alternative sourcing method that is more commonly used in practice. The theoretical results and managerial insights derived from this research can enable manufacturing firms to improve the management of their sourcing processes. In particular, we demonstrate that performance-based contracting with a symmetric linear penalty/reward function will always outperform the two-stage sourcing process from the perspective of the buyer and that the optimal penalty/reward rate is less than or equal to the unit warranty cost. In addition, performance-based contracting generally leads to a higher quality level provided by the winning supplier. However, the winning supplier is generally better off under the two-stage sourcing process.
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  • 86
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-07-22
    Description: We investigate when and how an original equipment manufacturer (OEM) should offer a trade-in rebate to recover used products in order to achieve better price discrimination and weaken competition from third-party remanufacturers (3PRs). This paper is motivated by a major IT equipment OEM, which negotiates with customers to offer them personalized trade-in rebates to induce them to return their old products and purchase new units. The company also faces increasing competition from 3PRs. We model such a trade-in program with negotiated rebates through a generalized Nash bargaining framework. Our main research question is whether the OEM should compete with a 3PR using only a trade-in program or by offering remanufactured products, or through both options. In the absence of 3PRs, the OEM always prefers to offer the trade-in program compared with not offering a trade-in program. As a trade-in program also helps to restrict the supply of used products to 3PRs, one would expect that offering a trade-in program would be more attractive in the presence of a 3PR. We show, however, that the OEM may find it detrimental to offer a trade-in program when faced with competition from a 3PR. We also show that despite the fact that cores are readily available via the trade-ins, the trade-in program makes it less attractive for the OEM to remanufacture. Finally, we show that offering a trade-in program may also lead to lower total environmental impact, but only in the presence of remanufactured products.
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  • 87
    Publication Date: 2016-07-22
    Description: Decision support systems (DSSs) for supply chain risk management benefit from a holistic approach for mitigating risks, which include identification and assessment of risks and evaluation and selection of measures to appease risks. However, previous studies in this area overlooked probability estimation, measure selection, and assessment of interdependence of risks and measures. We aim to fill these gaps in the literature by proposing a two-stage DSSs that will assist managers in not only select mitigation strategies for supply chain risks, but also mitigation tactics when risks occur. Our DSS employs a novel matrix formulation for decision-tree analysis, which integrates expert judgments. We applied our models to the supply chain of a fast-expanding offshore-wind industry, which faces high levels of exposure to risks because of the associated complexities in this domain. The results demonstrate how to select mitigation strategies and mitigation tactics for managing supply chain risks within the offshore-wind industry.
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  • 88
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-08-02
    Description: Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder that has recently seen serious increase in the number of affected subjects. In the last decade, neuroimaging has been shown to be a useful tool to understand AD and its prodromal stage, amnestic mild cognitive impairment (MCI). The majority of AD/MCI studies have focused on disease diagnosis, by formulating the problem as classification with a binary outcome of AD/MCI or healthy controls. There have recently emerged studies that associate image scans with continuous clinical scores that are expected to contain richer information than a binary outcome. However, very few studies aim at modeling multiple clinical scores simultaneously, even though it is commonly conceived that multivariate outcomes provide correlated and complementary information about the disease pathology. In this article, we propose a sparse multi-response tensor regression method to model multiple outcomes jointly as well as to model multiple voxels of an image jointly. The proposed method is particularly useful to both infer clinical scores and thus disease diagnosis, and to identify brain subregions that are highly relevant to the disease outcomes. We conducted experiments on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, and showed that the proposed method enhances the performance and clearly outperforms the competing solutions.
    Print ISSN: 0278-0062
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  • 89
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-08-02
    Description: A plethora of techniques for cardiac deformation imaging with 3D ultrasound, typically referred to as 3D speckle tracking techniques, are available from academia and industry. Although the benefits of single methods over alternative ones have been reported in separate publications, the intrinsic differences in the data and definitions used makes it hard to compare the relative performance of different solutions. To address this issue, we have recently proposed a framework to simulate realistic 3D echocardiographic recordings and used it to generate a common set of ground-truth data for 3D speckle tracking algorithms, which was made available online. The aim of this study was therefore to use the newly developed database to contrast non-commercial speckle tracking solutions from research groups with leading expertise in the field. The five techniques involved cover the most representative families of existing approaches, namely block-matching, radio-frequency tracking, optical flow and elastic image registration. The techniques were contrasted in terms of tracking and strain accuracy. The feasibility of the obtained strain measurements to diagnose pathology was also tested for ischemia and dyssynchrony.
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  • 90
    Publication Date: 2016-08-02
    Description: Ultra-high field MRI is an area of great interest for clinical research and basic science due to the increased signal-to-noise, spatial resolution and magnetic-susceptibility-based contrast. However, the fact that the electromagnetic wavelength in tissue is comparable to the relevant body dimensions means that the uniformity of the excitation field is much poorer than at lower field strengths. In addition to techniques such as transmit arrays, one simple but effective method to counteract this effect is to use high permittivity “pads”. Very high permittivities enable thinner, flexible pads to be used, but the limiting factor is wavelength effects within the pads themselves, which can lead to image artifacts. So far, all studies have used simple continuous rectangular/circular pad geometries. In this work we investigate how the wavelength effects can be partially mitigated utilizing shaped pad with holes. Several arrangements have been simulated, including low order pre-fractal geometries, which maintain the overall coverage of the pad, but can provide better image homogeneity in the region of interest or higher sensitivity depending on the setup. Experimental data in the form of in vivo human images at 7T were acquired to validate the simulation results.
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  • 91
    Publication Date: 2016-08-02
    Description: In this paper, we consider combined TV denoising and diffusion tensor fitting in DTI using the affine-invariant Riemannian metric on the space of diffusion tensors. Instead of first fitting the diffusion tensors, and then denoising them, we define a suitable TV type energy functional which incorporates the measured DWIs (using an inverse problem setup) and which measures the nearness of neighboring tensors in the manifold. To approach this functional, we propose generalized forward- backward splitting algorithms which combine an explicit and several implicit steps performed on a decomposition of the functional. We validate the performance of the derived algorithms on synthetic and real DTI data. In particular, we work on real 3D data. To our knowledge, the present paper describes the first approach to TV regularization in a combined manifold and inverse problem setup.
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  • 92
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-08-02
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  • 93
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-08-02
    Description: We present a generic method for automatic detection of abnormal regions in medical images as deviations from a normative data base. The algorithm decomposes an image, or more broadly a function defined on the image grid, into the superposition of a normal part and a residual term. A statistical model is constructed with regional sparse learning to represent normative anatomical variations among a reference population (e.g., healthy controls), in conjunction with a Markov random field regularization that ensures mutual consistency of the regional learning among partially overlapping image blocks. The decomposition is performed in a principled way so that the normal part fits well with the learned normative model, while the residual term absorbs pathological patterns, which may then be detected through a statistical significance test. The decomposition is applied to multiple image features from an individual scan, detecting abnormalities using both intensity and shape information. We form an iterative scheme that interleaves abnormality detection with deformable registration, gradually improving robustness of the spatial normalization and precision of the detection. The algorithm is evaluated with simulated images and clinical data of brain lesions, and is shown to achieve robust deformable registration and localize pathological regions simultaneously. The algorithm is also applied on images from Alzheimer’s disease patients to demonstrate the generality of the method.
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  • 94
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-08-02
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  • 95
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-08-02
    Description: Staining and scanning of tissue samples for microscopic examination is fraught with undesirable color variations arising from differences in raw materials and manufacturing techniques of stain vendors, staining protocols of labs, and color responses of digital scanners. When comparing tissue samples, color normalization and stain separation of the tissue images can be helpful for both pathologists and software. Techniques that are used for natural images fail to utilize structural properties of stained tissue samples and produce undesirable color distortions. The stain concentration cannot be negative. Tissue samples are stained with only a few stains and most tissue regions are characterized by at most one effective stain. We model these physical phenomena that define the tissue structure by first decomposing images in an unsupervised manner into stain density maps that are sparse and non-negative. For a given image, we combine its stain density maps with stain color basis of a pathologist-preferred target image, thus altering only its color while preserving its structure described by the maps. Stain density correlation with ground truth and preference by pathologists were higher for images normalized using our method when compared to other alternatives. We also propose a computationally faster extension of this technique for large whole-slide images that selects an appropriate patch sample instead of using the entire image to compute the stain color basis.
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  • 96
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-08-02
    Description: Prospective authors are requested to submit new, unpublished manuscripts for inclusion in the upcoming event described in this call for papers.
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  • 97
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-08-02
    Description: We present a methodology to recover the geometrical calibration of conventional X-ray settings with the help of an ordinary video camera and visible fiducials that are present in the scene. After calibration, equivalent points of interest can be easily identifiable with the help of the epipolar geometry. The same procedure also allows the measurement of real anatomic lengths and angles and obtains accurate 3D locations from image points. Our approach completely eliminates the need for X-ray-opaque reference marks (and necessary supporting frames) which can sometimes be invasive for the patient, occlude the radiographic picture, and end up projected outside the imaging sensor area in oblique protocols. Two possible frameworks are envisioned: a spatially shifting X-ray anode around the patient/object and a moving patient that moves/rotates while the imaging system remains fixed. As a proof of concept, experiences with a device under test (DUT), an anthropomorphic phantom and a real brachytherapy session have been carried out. The results show that it is possible to identify common points with a proper level of accuracy and retrieve three-dimensional locations, lengths and shapes with a millimetric level of precision. The presented approach is simple and compatible with both current and legacy widespread diagnostic X-ray imaging deployments and it can represent a good and inexpensive alternative to other radiological modalities like CT.
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  • 98
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-08-02
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  • 99
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-07-19
    Description: In this paper, a direct approach of designing robust weighted fusion steady-state Kalman predictors with uncertain noise variances is presented. Based on the steady-state Kalman filtering theory, using the minimax robust estimation principle, the local and six weighted fusion robust steady-state Kalman predictors are proposed based on the worst case systems with the conservative upper bounds of noise variances. They include the three robust weighted state fusers, two robust weighted measurement fusers, and a modified robust covariance intersection (CI) fuser. Their actual prediction error variances are guaranteed to have the corresponding minimal upper bounds for all admissible uncertainties. A Lyapunov equation approach for robustness analysis and the concept of the robust accuracy are presented and their robust accuracy relations are proved. A simulation example verifies the accuracy relations and robustness.
    Print ISSN: 0018-9251
    Electronic ISSN: 1557-9603
    Topics: Electrical Engineering, Measurement and Control Technology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 100
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016-07-19
    Description: In multitarget tracking, the problem of track labeling (assigning labels to tracks) is an ongoing research topic. The existing literature, however, lacks an appropriate measure of uncertainty related to the assigned labels that has a sound mathematical basis as well as clear practical meaning to the user. This is especially important in a situation where well separated targets move in close proximity with each other and thereafter separate again; in such a situation, it is well known that there will be confusion on target identities, also known as "mixed labeling." In this paper, we specify comprehensively the necessary assumptions for a Bayesian formulation of the multitarget tracking and labeling (MTTL) problem to be meaningful.We provide a mathematical characterization of the labeling uncertainties with clear physical interpretation.We also propose a novel labeling procedure that can be used in combination with any existing (unlabeled)MTT algorithm to obtain a Bayesian solution to the MTTL problem. One advantage of the resulting solution is that it readily provides the labeling uncertainty measures. Using the mixed labeling phenomenon in the presence of two targets as our test bed, we show with simulation results that an unlabeled multitarget sequential Monte Carlo (M-SMC) algorithm that employs sequential importance resampling (SIR) augmented with our labeling procedure performs much better than its "naive" extension, the labeled SIR M-SMC filter.
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    Topics: Electrical Engineering, Measurement and Control Technology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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