Publication Date:
2022-05-26
Description:
© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Horb, M., Wlizia, M., Abu-Daya, A., McNamara, S., Gajdasik, D., Igawa, T., Suzuki, A., Ogino, H., Noble, A., Centre de Ressource Biologique Xenope team in France, Robert, J., James-Zorn, C., Guille, M., Nicolas, M., Lafond, T., Boujard, D., Audic, Y., Guillet, B. Xenopus resources: Transgenic, inbred and mutant animals, training opportunities, and web-based support. Frontiers in Physiology, 10, (2019):387, doi:10.3389/fphys.2019.00387.
Description:
Two species of the clawed frog family, Xenopus laevis and X. tropicalis, are widely used as tools to investigate both normal and disease-state biochemistry, genetics, cell biology, and developmental biology. To support both frog specialist and non-specialist scientists needing access to these models for their research, a number of centralized resources exist around the world. These include centers that hold live and frozen stocks of transgenic, inbred and mutant animals and centers that hold molecular resources. This infrastructure is supported by a model organism database. Here, we describe much of this infrastructure and encourage the community to make the best use of it and to guide the resource centers in developing new lines and libraries.
Description:
The European Xenopus Resource Centre was funded by the Wellcome Trust (212942/Z/18/Z) and BBSRC (BB/R014841/1). The National Xenopus Resource was funded by the NIH (ORIP/NICHD) (Grant P40 OD010997). Major funding for Xenbase was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (Grant P41 HD064556). XLRRI was funded by the NIH/NIAID (R24-AI-059830 and R21AI139718). CRBX was funded by GIS-IBISA 2014 and Fondation Maladies Rares 2016. The National BioResource Project (NBRP) for Xenopus tropicalis was funded by Japan Agency for Medical Research and Development (AMED).
Keywords:
Xenopus laevis
;
Xenopus tropicalis
;
transgenesis
;
gene editing
;
inbred strains
;
ORFeome
;
model organism database
;
resource centers
Repository Name:
Woods Hole Open Access Server
Type:
Article
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