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1

Digitale Medien

Masthead (1985)

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 68 (1985)

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19850680101

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Inverted Hyperconjugation in Symmetrical 1,4-DihalocubanesPart IV of ‘The Equivalent Bond Orbital Model Revisited’ (Part III: [1]), and Part 50 of ‘Small and Medium Rings’ (Part 49: [1]). (1985)

Honegger, Evi ; Heilbronner, Edgar ; Urbanek, Thomas ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 68 (1985), S. 23-38

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The σ-orbital manifold of cubane 1, as suggested by its PE spectrum, is divided into two sets separated by a 3 eV gap extending from ∼ -10.5 eV to ∼ -13.5 eV. Halogen substituents with np AO basis energies falling into this gap (e.g. Cl or Br) will, therefore, hyperconjugate appreciably with both sets. Interaction with the lower-lying set will lead to the usual destabilization (‘normal’ hyperconjugation), whereas interaction with the set above will necessarily lead to a ‘stabilization’ (‘inverted’ hyperconjugation). As a result the lone-pair ionization energies of Cl or Br substituted cubanes (derived from PE spectra) are much larger than naively expected for an alkyl halide containing as much as 8 C-atoms. In particular no significant shift of the eg-1 lone-pair bands in the PE spectra of 1,4-dichloro- and 1,4-dibromocubane can be detected with respect to the first ionization energies of the free atoms Cl and Br, or of HCl and HBr.

Zusätzliches Material: 7 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19850680104

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Digitale Medien

Sesquiterpenoids of the Sponge Dysidea fragilis of the North-Brittany SeaPresented by F.P. as a part of a lecture at the University of Innsbruck on March 15th, 1984. (1985)

Guella, Graziano ; Guerriero, Antonio ; Pietra, Francesco

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 68 (1985), S. 39-48

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The title sponge is shown to contain eight new sesquiterpenoids for which a common, unusual biogenetic origin is postulated. The compounds are shown to be: (-)-(1R*,4R*)-3-(3′-furyl)methyl-2-p-menthen-7-yl acetate ((-)-8b); two diols separated as the monoacetates (-)-(1S*,4R*)-3-(3′-furyl)methyl-l-hydroxy-2-p-menthen-7-yl acetate ((-)-13a) and the (-)-(1R*,4R*)-epimer (-)-13b, the two C(4)-epimeric 4-ethoxy-3-(1′(7′),2′-p-menthadien-3′-yl)methyl-2-buten-4-olides ((+)-14a and (-)-14b), (-)-3-(3′-furyl)methyl-7-nor-2-p-menthen-l-one ((-)-11), (-)-(3Z)-1-(3′-furyl)-4,8-dimethylnona-3, 7-dien-2-yl acetate ((-)-17), and (+)-3-(5′,7′-seco-2′(10′)-pinen-7′-yl)methylfuran ((+)-15).

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19850680105

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4

Digitale Medien

Melanotropin Receptors I. Synthesis and Biological Activity of Nα-(5-Bromovaleryl)-Nα-deacetyl-α-melanotropinParts of this report have appeared as a thesis [1]. Nomenclature and abbreviations [2]. Additional abbreviations: MSH = melanophore stimulating hormone (melanotropin), DCC = N, N′-dicyclohexylcarbodiimide, DCU = N, N′-dicyclohexylurea, DMF = dimethylformamide, HOBt = 1-hydroxybenzotriazole, Boc = tert-butoxycarbonyl, OBut = tert-butoxy, Msoc = 2-(methylsulfonyl)ethoxycarbonyl, Np = 4-nitrophenyl, Z = benzyloxycarbonyl, TFA = trifluoroacetic acid. Chiral amino acids are in their L-configuration. Culture media see Experimental.Dedicated to Dr. Nitya Anand, Director of the Central Drug Research Institute, Lucknow, India, on the occasion of his 60th birthday (1985)

Wunderlin, Rudolf ; Minakakis, Panagiota ; Tun-Kyi, Aung ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 68 (1985), S. 1-11

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Chemical synthesis and biological activities of a new α-melanotropin derivative are described. Nα-(5-Bromovaleryl)-Nα-deacetyl-α-melanotropin contains the 5-bromopentanoyl group as a chemical ‘handle’ in place of the acetyl group of the natural hormone. The synthesis involved a new protected intermediate which allowed the selective deprotection of either the Nα or Nα amino group. The title compound reacted with sodium thiosulfate to give Nα-deacetyl-Nα-(5-(sulfothio)valeryl)-α-melanotropin, a key intermediate for the preparation of tobaccomosaic virus/α-melanotropin disulfide conjugates. As a basis for the study of the conjugates, biological activities of the title compound on Cloudman S-91 mouse melanoma cell cultures (tyrosinase stimulation, binding, and cyclic AMP accumulation) were determined. They proved to be quite similar to the corresponding α-melanotropin activities. Differences in bindings may be explained by stronger hydrophobic interaction of the new derivative with the lipid phase of the target cell membranes.

Zusätzliches Material: 9 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19850680102

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5

Digitale Medien

Bond Angles in Lactones and Lactams (1985)

Nørskov-Lauritsen, Leif ; Bürgi, Hans-Beat ; Hofmann, Peter ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 68 (1985), S. 76-82

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The carbonyl group in lactones and, to a lesser extent, in lactams tends to show a C—C=O angle that is larger than the O—C=O or N—C=O angle, the difference increasing in magnitude as the ring size decreases. The observed trend provides information on ratios of force constants characterising the flexibility of the s-cis-ester group and may be interpreted in terms of incipient chemical reaction to -O—(CH2)n—C≡O+. Molecular orbital calculations (MINDO/3, MNDO, EH) for model compounds provide an electronic interpretation of this angle difference in terms of an anomeric interaction between the p-type lone pair on the carbonyl O-atom and the antibonding C-O or C-N orbital.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19850680110

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6

Digitale Medien

Cyclic Octa- and Decapeptides as Ionophores for Magnesium (1985)

Behm, Felix ; Ammann, Daniel ; Simon, Wilhelm ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 68 (1985), S. 110-118

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Cyclic octa- and decapeptides have been prepared, and their ion selectivity in solvent polymeric membranes was studied. Cyclo(-LPro-DLeu-)5 behaves as an ionophore which selects Mg2+ over Ca2+ by a factor of 100. Cyclo(LPro-LLeu)5 induces selectivity in membranes for Mg2+ over Li+, Na+ and K+ by a factor of 400, 200 and 10, respectively, while selectivity of Mg2+ over Ca2+ is poor. Some evidence is presented which indicates that certain ionophores exhibit high selectivity for monovalent magnesium complexes.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19850680114

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7

Digitale Medien

Stereoselective Double Functionalization of Iron-Carbonyl Complexes of 5,6,7,8-Tetramethylidenebicyclo[2.2.2]oct-2-ene. Crystal Structure and Absolute Configuration of (-)-trans-μ-[(2S,5R,7S)-C,5,6,C-η:C,7,8,C-η-(6,7,8-trimethylidene-5-((Z)-2-oxopropylidene)-2-bicyclo[2.2.2]octyl acetate)]-bis(tricarbonyliron) (1985)

Tagliaferri, Enrico ; Campiche, Philippe ; Roulet, Raymond ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 68 (1985), S. 126-134

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The Friedel-Crafts monoacylation of trans-η-[(1RS,2RS,4SR,5SR,6RS,7SR,8SR)-C,5,6,C-η:C,7,8,C-η-(5,6,7,8-tetramethylidene-2-bicyclo[2.2.2]octyl acetate)]-bis(tricarbonyliron) ((±)-5) is highly stereoselective and yields trans-η-[(1RS,2RS,4RS,5SR,6RS,7RS,8SR)-C,6-η,oxo-σ:C,7,8,C-η-(6,7,8-trimethylidene-5-((Z)-2-oxopropylidene)-2-bicyclo[2.2.2]octyl acetate)]-bis(tricarbonyliron) ((±)-8) which equilibrates with the trans-η-[(1RS,2RS,4RS,5SR,6RS,7RS,8SR)-C,5,6,C-η:C,7,8,C-η-(6,7,8-trimethylidene-5-((Z)-2-oxopropylidene)-2-bicyclo[2.2.2]octyl acetate)]-bis(tricarbonyliron) ((±)-9) on heating. Optically pure (-)-9 has been prepared from the corresponding optically pure alcohol (+)-4. The structure and absolute configuration of (-)-9 was established by single-crystal X-ray diffraction.

Zusätzliches Material: 4 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19850680116

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8

Digitale Medien

Alkylierung in der 2-Stellung von (2S, 4R)- 4-Hydroxyprolin unter Retention (1985)

Weber, Theodor ; Seebach, Dieter

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 68 (1985), S. 155-161

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Alkylation in the 2-Position of (2S, 4R)-4-Hydroxyproline with Retention of ConfigurationO-Acetyl-4-hydroxyproline (1b) is condensed with pivalaldehyde to give a single stereoisomer of the 2-(tert-butyl)-4-oxo-3-oxa-1-azabicyclo[3.3.0]oct-7-yl acetate (3). This is converted to the enolates 4 or 5, reactions of which with alkyl halides, aldehydes, and acetone (→6,9,10,11) are diastereoselective (lk-1,3-induction). Cleavage of the corresponding products furnishes the enantiomerically pure 2-deuterio-, 2-methyl-, 2-allyl-, and 2-benzyl-substituted 4-hydroxyprolines 2a-2d.

Zusätzliches Material: 2 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19850680119

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9

Digitale Medien

Über den sterischen Verlauf der Umsetzung von Enaminen aus offenkettigen Aldehyden und Ketonen mit Nitroolefinen zu 2,3-disubstituierten 4-NitroketonenTeilweise in einer Kurzmitteilung beschrieben [1]. (1985)

Seebach, Dieter ; Beck, Albert K. ; Goliński, Jerzy ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 68 (1985), S. 162-172

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: On the Steric Course of the Reaction of Enamines Derived from Open-Chain Aldehydes and Ketones with Nitro-olefins Yielding 2,3-Disubstituted 4-NitroketonesThe relative configuration of the nitro-ketone 12 obtained by the title reaction has been proved by a Baeyer-Villiger degradation and subsequent reduction to the amino-alcohol (±)-(u)-20, the relative configuration of which is identical with a sample prepared from 2-methyl-3-hydroxybutyrate of known configuration (Scheme 1). The stereochemical course of the title reaction is thus as predicted by our topological rule. It is assumed that the other nitro-ketones 13-18 described here are also formed by (lk)-combination of the trigonal centers of the educts (diastereoselectivity 〉 90%, see Formulae and Fig. 1). It is not possible to reverse this relative topicity by employing (Z)- instead of (E)-components of the starting materials, due to the reversibility of the primary step of these Michael additions (Schemes 2 and 3, and Fig. 2).

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19850680120

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10

Digitale Medien

Photochemical reactions. 142nd communication141st Communication: [1].. Photochemistry of a 6,7-epoxy-1,3-diene of the ionone series (1985)

Mathies, Peter ; Frei, Bruno ; Jeger, Oskar

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 68 (1985), S. 207-211

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: On singlet excitation (λ = 254 nm), the epoxydiene (E)-3 underwent (E)/(Z)-isomerization, electrocyclic ring closure of the diene side chain leading to the cyclobutenes 4A + B, and rearrangement to the cyclohexanones 5A + B. Compounds 5A + B were presumably formed in a series of processes including a 1,3-acyl shift of the homoconjugated ketone 8, arising from (Z)-3 by a 1,5-H-shift accompanied by cleavage of the C,O-bond of the oxirane.

Zusätzliches Material: 1 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19850680125

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