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  • Articles  (6,118)
  • Institute of Electrical and Electronics Engineers (IEEE)  (6,118)
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  • 1
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: Presents the front cover for this issue of the publication.
    Print ISSN: 1520-9202
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  • 2
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: Six senior computer science educators answer questions about the current state of computer science education, software engineering, and licensing software engineers.
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  • 3
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: Provides a listing of current staff, committee members and society officers.
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  • 4
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: The Internet of Things is a new department with the mission of presenting fresh ideas and applications from a practitioner point of view. The authors are interested in showcasing articles about real, implemented Internet of Things (IoT) systems.
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  • 5
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: Commemorating the 20th anniversary of IT Professional, the advisory board chair and four past editors in chief reflect on the first two decades of the magazine.
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  • 6
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: In a case study where a Dutch small-to-medium enterprise (SME) implemented test-driven development and continuous integration, researchers observed that the SME discovered a higher number of defects compared to a baseline case study, and that there was an increase in the focus on quality and test applications.
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  • 7
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: By providing access to data from numerous systems in one database and supporting the systems that can produce an appropriate customer experience, a customer data platform overcomes the limitations imposed by fragmented point solutions and presents a holistic approach to customer interactions.
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  • 8
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: An introduction to the new Life in the C-Suite column, which will help C-level executives understand the vast digital world in which they live, and how they should leverage digital technology into their business processes and business models.
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  • 9
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: Student Forum is a new column that intends to connect IT students with industry, government, and academia.
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  • 10
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: The new IT Economics department seeks to advance the understanding of various microeconomic and macroeconomic issues that IT managers need to examine in their decisions to adopt and implement information and communications technology-related systems, services, processes, and practices.
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  • 11
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: Provides a listing of current committee members and society officers.
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  • 12
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-02-16
    Description: Prospective authors are requested to submit new, unpublished manuscripts for inclusion in the upcoming event described in this call for papers.
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  • 13
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-03-06
    Description: Encouraged by the recent progress in pedestrian detection, we investigate the gap between current state-of-the-art methods and the “perfect single frame detector”. We enable our analysis by creating a human baseline for pedestrian detection (over the Caltech pedestrian dataset). After manually clustering the frequent errors of a top detector, we characterise both localisation and background-versus-foreground errors. To address localisation errors we study the impact of training annotation noise on the detector performance, and show that we can improve results even with a small portion of sanitised training data. To address background/foreground discrimination, we study convnets for pedestrian detection, and discuss which factors affect their performance. Other than our in-depth analysis, we report top performance on the Caltech pedestrian dataset, and provide a new sanitised set of training and test annotations.
    Print ISSN: 0162-8828
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  • 14
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-03-06
    Description: This paper addresses the problem of robust and efficient relative rotation averaging in the context of large-scale Structure from Motion. Relative rotation averaging finds global or absolute rotations for a set of cameras from a set of observed relative rotations between pairs of cameras. We propose a generalized framework of relative rotation averaging that can use different robust loss functions and jointly optimizes for all the unknown camera rotations. Our method uses a quasi-Newton optimization which results in an efficient iteratively reweighted least squares (IRLS) formulation that works in the Lie algebra of the 3D rotation group. We demonstrate the performance of our approach on a number of large-scale data sets. We show that our method outperforms existing methods in the literature both in terms of speed and accuracy.
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  • 15
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Speaker diarization consists of assigning speech signals to people engaged in a dialogue. An audio-visual spatiotemporal diarization model is proposed. The model is well suited for challenging scenarios that consist of several participants engaged in multi-party interaction while they move around and turn their heads towards the other participants rather than facing the cameras and the microphones. Multiple-person visual tracking is combined with multiple speech-source localization in order to tackle the speech-to-person association problem. The latter is solved within a novel audio-visual fusion method on the following grounds: binaural spectral features are first extracted from a microphone pair, then a supervised audio-visual alignment technique maps these features onto an image, and finally a semi-supervised clustering method assigns binaural spectral features to visible persons. The main advantage of this method over previous work is that it processes in a principled way speech signals uttered simultaneously by multiple persons. The diarization itself is cast into a latent-variable temporal graphical model that infers speaker identities and speech turns, based on the output of an audio-visual association process, executed at each time slice, and on the dynamics of the diarization variable itself. The proposed formulation yields an efficient exact inference procedure. A novel dataset, that contains audio-visual training data as well as a number of scenarios involving several participants engaged in formal and informal dialogue, is introduced. The proposed method is thoroughly tested and benchmarked with respect to several state-of-the art diarization algorithms.
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  • 16
    Publication Date: 2018-04-04
    Description: The capabilities of (I) learning transferable knowledge across domains; and (II) fine-tuning the pre-learned base knowledge towards tasks with considerably smaller data scale are extremely important. Many of the existing transfer learning techniques are supervised approaches, among which deep learning has the demonstrated power of learning domain transferrable knowledge with large scale network trained on massive amounts of labeled data. However, in many biomedical tasks, both the data and the corresponding label can be very limited, where the unsupervised transfer learning capability is urgently needed. In this paper, we proposed a novel multi-scale convolutional sparse coding (MSCSC) method, that (I) automatically learns filter banks at different scales in a joint fashion with enforced scale-specificity of learned patterns; and (II) provides an unsupervised solution for learning transferable base knowledge and fine-tuning it towards target tasks. Extensive experimental evaluation of MSCSC demonstrates the effectiveness of the proposed MSCSC in both regular and transfer learning tasks in various biomedical domains.
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  • 17
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Learning visual representations from web data has recently attracted attention for object recognition. Previous studies have mainly focused on overcoming label noise and data bias and have shown promising results by learning directly from web data. However, we argue that it might be better to transfer knowledge from existing human labeling resources to improve performance at nearly no additional cost. In this paper, we propose a new semi-supervised method for learning via web data. Our method has the unique design of exploiting strong supervision, i.e., in addition to standard image-level labels, our method also utilizes detailed annotations including object bounding boxes and part landmarks. By transferring as much knowledge as possible from existing strongly supervised datasets to weakly supervised web images, our method can benefit from sophisticated object recognition algorithms and overcome several typical problems found in webly-supervised learning. We consider the problem of fine-grained visual categorization, in which existing training resources are scarce, as our main research objective. Comprehensive experimentation and extensive analysis demonstrate encouraging performance of the proposed approach, which, at the same time, delivers a new pipeline for fine-grained visual categorization that is likely to be highly effective for real-world applications.
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  • 18
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: We are motivated by the need for a generic object proposal generation algorithm which achieves good balance between object detection recall, proposal localization quality and computational efficiency. We propose a novel object proposal algorithm, BING++ , which inherits the virtue of good computational efficiency of BING [1] but significantly improves its proposal localization quality. At high level we formulate the problem of object proposal generation from a novel probabilistic perspective, based on which our BING++ manages to improve the localization quality by employing edges and segments to estimate object boundaries and update the proposals sequentially. We propose learning the parameters efficiently by searching for approximate solutions in a quantized parameter space for complexity reduction. We demonstrate the generalization of BING++ with the same fixed parameters across different object classes and datasets. Empirically our BING++ can run at half speed of BING on CPU, but significantly improve the localization quality by 18.5 and 16.7 percent on both VOC2007 and Microhsoft COCO datasets, respectively. Compared with other state-of-the-art approaches, BING++ can achieve comparable performance, but run significantly faster.
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  • 19
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Recent years have witnessed the success of deep neural networks in dealing with a plenty of practical problems. Dropout has played an essential role in many successful deep neural networks, by inducing regularization in the model training. In this paper, we present a new regularized training approach: Shakeout. Instead of randomly discarding units as Dropout does at the training stage, Shakeout randomly chooses to enhance or reverse each unit's contribution to the next layer. This minor modification of Dropout has the statistical trait: the regularizer induced by Shakeout adaptively combines $L_{0}$ , $L_{1}$ and $L_{2}$ regularization terms. Our classification experiments with representative deep architectures on image datasets MNIST, CIFAR-10 and ImageNet show that Shakeout deals with over-fitting effectively and outperforms Dropout. We empirically demonstrate that Shakeout leads to sparser weights under both unsupervised and supervised settings. Shakeout also leads to the grouping effect of the input units in a layer. Considering the weights in reflecting the importance of connections, Shakeout is superior to Dropout, which is valuable for the deep model compression. Moreover, we demonstrate that Shakeout can effectively reduce the instability of the training process of the deep architecture.
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  • 20
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
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  • 21
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: The goal of this paper is to perform 3D object detection in the context of autonomous driving. Our method aims at generating a set of high-quality 3D object proposals by exploiting stereo imagery. We formulate the problem as minimizing an energy function that encodes object size priors, placement of objects on the ground plane as well as several depth informed features that reason about free space, point cloud densities and distance to the ground. We then exploit a CNN on top of these proposals to perform object detection. In particular, we employ a convolutional neural net (CNN) that exploits context and depth information to jointly regress to 3D bounding box coordinates and object pose. Our experiments show significant performance gains over existing RGB and RGB-D object proposal methods on the challenging KITTI benchmark. When combined with the CNN, our approach outperforms all existing results in object detection and orientation estimation tasks for all three KITTI object classes. Furthermore, we experiment also with the setting where LIDAR information is available, and show that using both LIDAR and stereo leads to the best result.
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  • 22
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Print ISSN: 1545-5963
    Electronic ISSN: 1557-9964
    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 23
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Phylogenetic tree reconciliation is an important technique for reconstructing the evolutionary histories of species and genes and other dependent entities. Reconciliation is typically performed in a maximum parsimony framework and the number of optimal reconciliations can grow exponentially with the size of the trees, making it difficult to understand the solution space. This paper demonstrates how a small number of reconciliations can be found that collectively contain the most highly supported events in the solution space. While we show that the formal problem is NP-complete, we give a $1-frac{1}{e}$ approximation algorithm, experimental results that indicate its effectiveness, and the new DTL-RnB software tool that uses our algorithms to summarize the space of optimal reconciliations ( www.cs.hmc.edu/dtlrnb ).
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    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 24
    Publication Date: 2018-04-04
    Description: We propose a methodology for model-based fault detection and diagnosis for stochastic Boolean dynamical systems indirectly observed through a single time series of transcriptomic measurements using Next Generation Sequencing (NGS) data. The fault detection consists of an innovations filter followed by a fault certification step, and requires no knowledge about the possible system faults. The innovations filter uses the optimal Boolean state estimator, called the Boolean Kalman Filter (BKF). In the presence of knowledge about the possible system faults, we propose an additional step of fault diagnosis based on a multiple model adaptive estimation (MMAE) method consisting of a bank of BKFs running in parallel. Performance is assessed by means of false detection and misdiagnosis rates, as well as average times until correct detection and diagnosis. The efficacy of the proposed methodology is demonstrated via numerical experiments using a p53-MDM2 negative feedback loop Boolean network with stuck-at faults that model molecular events commonly found in cancer.
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    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 25
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    Publication Date: 2018-04-04
    Description: New de novo transcriptome assembly and annotation methods provide an incredible opportunity to study the transcriptome of organisms that lack an assembled and annotated genome. There are currently a number of de novo transcriptome assembly methods, but it has been difficult to evaluate the quality of these assemblies. In order to assess the quality of the transcriptome assemblies, we composed a workflow of multiple quality check measurements that in combination provide a clear evaluation of the assembly performance. We presented novel transcriptome assemblies and functional annotations for Pacific Whiteleg Shrimp ( Litopenaeus vannamei ), a mariculture species with great national and international interest, and no solid transcriptome/genome reference. We examined Pacific Whiteleg transcriptome assemblies via multiple metrics, and provide an improved gene annotation. Our investigations show that assessing the quality of an assembly purely based on the assembler's statistical measurements can be misleading; we propose a hybrid approach that consists of statistical quality checks and further biological-based evaluations.
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    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 26
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
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    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 27
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Hi-C technology, a chromosome conformation capture (3C) based method, has been developed to capture genome-wide interactions at a given resolution. The next challenge is to reconstruct 3D structure of genome from the 3C-derived data computationally. Several existing methods have been proposed to obtain a consensus structure or ensemble structures. These methods can be categorized as probabilistic models or restraint-based models. In this paper, we propose a method, named ShRec3D+, to infer a consensus 3D structure of a genome from Hi-C data. The method is a two-step algorithm which is based on ChromSDE and ShRec3D methods. First, correct the conversion factor by golden section search for converting interaction frequency data to a distance weighted graph. Second, apply shortest-path algorithm and multi-dimensional scaling (MDS) algorithm to compute the 3D coordinates of a set of genomic loci from the distance graph. We validate ShRec3D+ accuracy on both simulation data and publicly Hi-C data. Our test results indicate that our method successfully corrects the parameter with a given resolution, is more accurate than ShRec3D, and is more efficient and robust than ChromSDE.
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    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 28
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Determining gender by examining the human brain is not a simple task because the spatial structure of the human brain is complex, and no obvious differences can be seen by the naked eyes. In this paper, we propose a novel three-dimensional feature descriptor, the three-dimensional weighted histogram of gradient orientation (3D WHGO) to describe this complex spatial structure. The descriptor combines local information for signal intensity and global three-dimensional spatial information for the whole brain. We also improve a framework to address the classification of three-dimensional images based on MRI. This framework, three-dimensional spatial pyramid, uses additional information regarding the spatial relationship between features. The proposed method can be used to distinguish gender at the individual level. We examine our method by using the gender identification of individual magnetic resonance imaging (MRI) scans of a large sample of healthy adults across four research sites, resulting in up to individual-level accuracies under the optimized parameters for distinguishing between females and males. Compared with previous methods, the proposed method obtains higher accuracy, which suggests that this technology has higher discriminative power. With its improved performance in gender identification, the proposed method may have the potential to inform clinical practice and aid in research on neurological and psychiatric disorders.
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    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 29
    Publication Date: 2018-04-04
    Description: Ultra-high dimensional variable selection has become increasingly important in analysis of neuroimaging data. For example, in the Autism Brain Imaging Data Exchange (ABIDE) study, neuroscientists are interested in identifying important biomarkers for early detection of the autism spectrum disorder (ASD) using high resolution brain images that include hundreds of thousands voxels. However, most existing methods are not feasible for solving this problem due to their extensive computational costs. In this work, we propose a novel multiresolution variable selection procedure under a Bayesian probit regression framework. It recursively uses posterior samples for coarser-scale variable selection to guide the posterior inference on finer-scale variable selection, leading to very efficient Markov chain Monte Carlo (MCMC) algorithms. The proposed algorithms are computationally feasible for ultra-high dimensional data. Also, our model incorporates two levels of structural information into variable selection using Ising priors: the spatial dependence between voxels and the functional connectivity between anatomical brain regions. Applied to the resting state functional magnetic resonance imaging (R-fMRI) data in the ABIDE study, our methods identify voxel-level imaging biomarkers highly predictive of the ASD, which are biologically meaningful and interpretable. Extensive simulations also show that our methods achieve better performance in variable selection compared to existing methods.
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    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 30
    Publication Date: 2018-04-04
    Description: In systems neuroscience, it is becoming increasingly common to record the activity of hundreds of neurons simultaneously via electrode arrays. The ability to accurately measure the causal interactions among multiple neurons in the brain is crucial to understanding how neurons work in concert to generate specific brain functions. The development of new statistical methods for assessing causal influence between spike trains is still an active field of neuroscience research. Here, we suggest a copula-based Granger causality measure for the analysis of neural spike train data. This method is built upon our recent work on copula Granger causality for the analysis of continuous-valued time series by extending it to point-process neural spike train data. The proposed method is therefore able to reveal nonlinear and high-order causality in the spike trains while retaining all the computational advantages such as model-free, efficient estimation, and variability assessment of Granger causality. The performance of our algorithm can be further boosted with time-reversed data. Our method performed well on extensive simulations, and was then demonstrated on neural activity simultaneously recorded from primary visual cortex of a monkey performing a contour detection task.
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    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 31
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    Publication Date: 2018-04-04
    Description: The focus of this paper is the frequent gene team problem. Given a quorum parameter μ and a set of m genomes, the problem is to find gene teams that occur in at least μ of the given genomes. In this paper, a new algorithm is presented. Previous solutions are efficient only when μ is small. Unlike previous solutions, the presented algorithm does not rely on examining every combination of μ genomes. Its time complexity is independent of μ. Under some realistic assumptions, the practical running time is estimated to be $O(m^{2}n^{2}; {mathrm{lg}};n)$ , where n is the maximum length of the input genomes. Experiments showed that the presented algorithm is extremely efficient. For any μ, it takes less than 1 second to process 100 bacterial genomes and takes only 10 minutes to process 2,000 genomes. The presented algorithm can be used as an effective tool for large scale genome analyses.
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    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 32
    Publication Date: 2018-04-04
    Description: In this era of genome-wide association studies (GWAS), the quest for understanding the genetic architecture of complex diseases is rapidly increasing more than ever before. The development of high throughput genotyping and next generation sequencing technologies enables genetic epidemiological analysis of large scale data. These advances have led to the identification of a number of single nucleotide polymorphisms (SNPs) responsible for disease susceptibility. The interactions between SNPs associated with complex diseases are increasingly being explored in the current literature. These interaction studies are mathematically challenging and computationally complex. These challenges have been addressed by a number of data mining and machine learning approaches. This paper reviews the current methods and the related software packages to detect the SNP interactions that contribute to diseases. The issues that need to be considered when developing these models are addressed in this review. The paper also reviews the achievements in data simulation to evaluate the performance of these models. Further, it discusses the future of SNP interaction analysis.
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    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 33
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    Publication Date: 2018-04-04
    Description: Motifs in complex biological, technological, and social networks, or in other types of networks are connected to patterns that occur at significantly higher frequency compared to similar random networks. Finding motifs helps scientists to know more about networks’ structure and function, and this goal cannot be achieved without efficient algorithms. Existing methods for counting network motifs are extremely costly in CPU time and memory consumption. In addition, they restrict to the larger motifs. In this paper, a new algorithm called FraMo is presented based on ‘fractal theory’. This method consists of three phases: at first, a complex network is converted to a multifractal network. Then, using maximum likelihood estimation, distribution parameters is estimated for the multifractal network, and at last the approximate number of network motifs is calculated. Experimental results on several benchmark datasets show that our algorithm can efficiently approximate the number of motifs in any size in undirected networks and compare its performance favorably with similar existing algorithms in terms of CPU time and memory usage.
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    Topics: Biology , Computer Science
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    Publication Date: 2018-04-04
    Description: Regions of interest (ROIs) based classification has been widely investigated for analysis of brain magnetic resonance imaging (MRI) images to assist the diagnosis of Alzheimer's disease (AD) including its early warning and developing stages, e.g., mild cognitive impairment (MCI) including MCI converted to AD (MCIc) and MCI not converted to AD (MCInc). Since an ROI representation of brain structures is obtained either by pre-definition or by adaptive parcellation, the corresponding ROI in different brains can be measured. However, due to noise and small sample size of MRI images, representations generated from single or multiple ROIs may not be sufficient to reveal the underlying anatomical differences between the groups of disease-affected patients and health controls (HC). In this paper, we employ a whole brain hierarchical network (WBHN) to represent each subject. The whole brain of each subject is divided into 90, 54, 14, and 1 regions based on Automated Anatomical Labeling (AAL) atlas. The connectivity between each pair of regions is computed in terms of Pearson's correlation coefficient and used as classification feature. Then, to reduce the dimensionality of features, we select the features with higher $F-$ scores. Finally, we use multiple kernel boosting (MKBoost) algorithm to perform the classification. Our proposed method is evaluated on MRI images of 710 subjects (200 AD, 120 MCIc, 160 MCInc, and 230 HC) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. The experimental results show that our proposed method achieves an accuracy of 94.65 percent and an area under the receiver operating characteristic (ROC) curve (AUC) of 0.954 for AD/HC classification, an accuracy of 89.63 percent and an AUC of 0.907 for AD/MCI classification, an- accuracy of 85.79 percent and an AUC of 0.826 for MCI/HC classification, and an accuracy of 72.08 percent and an AUC of 0.716 for MCIc/MCInc classification, respectively. Our results demonstrate that our proposed method is efficient and promising for clinical applications for the diagnosis of AD via MRI images.
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    Publication Date: 2018-04-04
    Description: Enumeration of chemical structures is useful for drug design, which is one of the main targets of computational biology and bioinformatics. A chemical graph $G$ with no other cycles than benzene rings is called tree-like , and becomes a tree $T$ possibly with multiple edges if we contract each benzene ring into a single virtual atom of valence 6. All tree-like chemical graphs with a given tree representation $T$ are called the substituted benzene isomers of $T$ . When we replace each virtual atom in $T$ with a benzene ring to obtain a substituted benzene isomer, distinct isomers of $T$ are caused by the difference in arrangements of atom groups around a benzene ring. In this paper, we propose an efficient algorithm that enumerates all substituted benzene isomers of a given tree representation $T$ . Our algorithm first counts the number
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  • 36
    Publication Date: 2018-04-04
    Description: Determining the dynamics of pathways associated with cancer progression is critical for understanding the etiology of diseases. Advances in biological technology have facilitated the simultaneous genomic profiling of multiple patients at different clinical stages, thus generating the dynamic genomic data for cancers. Such data provide enable investigation of the dynamics of related pathways. However, methods for integrative analysis of dynamic genomic data are inadequate. In this study, we develop a novel nonnegative matrix factorization algorithm for dynamic modules ( NMF-DM ), which simultaneously analyzes multiple networks for the identification of stage-specific and dynamic modules. NMF-DM applies the temporal smoothness framework by balancing the networks at the current stage and the previous stage. Experimental results indicate that the NMF-DM algorithm is more accurate than the state-of-the-art methods in artificial dynamic networks. In breast cancer networks, NMF-DM reveals the dynamic modules that are important for cancer stage transitions. Furthermore, the stage-specific and dynamic modules have distinct topological and biochemical properties. Finally, we demonstrate that the stage-specific modules significantly improve the accuracy of cancer stage prediction. The proposed algorithm provides an effective way to explore the time-dependent cancer genomic data.
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  • 37
    Publication Date: 2018-04-04
    Description: MicroRNAs (miRNAs) are known as an important indicator of cancers. The presence of cancer can be detected by identifying the responsible miRNAs. A fuzzy-rough entropy measure (FREM) is developed which can rank the miRNAs and thereby identify the relevant ones. FREM is used to determine the relevance of a miRNA in terms of separability between normal and cancer classes. While computing the FREM for a miRNA, fuzziness takes care of the overlapping between normal and cancer expressions, whereas rough lower approximation determines their class sizes. MiRNAs are sorted according to the highest relevance (i.e., the capability of class separation) and a percentage among them is selected from the top ranked ones. FREM is also used to determine the redundancy between two miRNAs and the redundant ones are removed from the selected set, as per the necessity. A histogram based patient selection method is also developed which can help to reduce the number of patients to be dealt during the computation of FREM, while compromising very little with the performance of the selected miRNAs for most of the data sets. The superiority of the FREM as compared to some existing methods is demonstrated extensively on six data sets in terms of sensitivity, specificity, and $F$ score. While for these data sets the $F$ score of the miRNAs selected by our method varies from 0.70 to 0.91 using SVM, those results vary from 0.37 to 0.90 for some other methods. Moreover, all the selected miRNAs corroborate with the findings of biological investigations or pathway analysis tools. The source code of FREM is available at http://www.jayanta.droppages.com/FREM.html .
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  • 38
    Publication Date: 2018-04-04
    Description: Identification of combinatorial markers from multiple data sources is a challenging task in bioinformatics. Here, we propose a novel computational framework for identifying significant combinatorial markers ( $SCM$ s) using both gene expression and methylation data. The gene expression and methylation data are integrated into a single continuous data as well as a (post-discretized) boolean data based on their intrinsic (i.e., inverse) relationship. A novel combined score of methylation and expression data (viz., $CoMEx$ ) is introduced which is computed on the integrated continuous data for identifying initial non-redundant set of genes. Thereafter, (maximal) frequent closed homogeneous genesets are identified using a well-known biclustering algorithm applied on the integrated boolean data of the determined non-redundant set of genes. A novel sample-based weighted support ( $WS$ ) is then proposed that is consecutively calculated on the integrated boolean data of the determined non-redundant set of genes in order to identify the non-redundant significant genesets. The top few resulting genesets are identified as potential $SCM$ s. Since our proposed method generates a smaller number of significant non-redundant genesets than those by other popular methods, the method is much faster than the others. Application of the proposed techniq- e on an expression and a methylation data for Uterine tumor or Prostate Carcinoma produces a set of significant combination of markers. We expect that such a combination of markers will produce lower false positives than individual markers.
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  • 39
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    Publication Date: 2018-03-06
    Description: In this paper, we seek to improve deep neural networks by generalizing the pooling operations that play a central role in the current architectures. We pursue a careful exploration of approaches to allow pooling to learn and to adapt to complex and variable patterns. The two primary directions lie in: (1) learning a pooling function via (two strategies of) combining of max and average pooling, and (2) learning a pooling function in the form of a tree-structured fusion of pooling filters that are themselves learned. In our experiments every generalized pooling operation we explore improves performance when used in place of average or max pooling. We experimentally demonstrate that the proposed pooling operations provide a boost in invariance properties relative to conventional pooling and set the state of the art on several widely adopted benchmark datasets. These benefits come with only a light increase in computational overhead during training (ranging from additional 5 to 15 percent in time complexity) and a very modest increase in the number of model parameters (e.g., additional 1, 9, and 27 parameters for mixed, gated, and 2-level tree pooling operators, respectively). To gain more insights about our proposed pooling methods, we also visualize the learned pooling masks and the embeddings of the internal feature responses for different pooling operations. Our proposed pooling operations are easy to implement and can be applied within various deep neural network architectures.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Presents the front cover for this issue of the publication.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: The IEEE Geocience and Remote Sensing Society (GRSS) Nominations Committee calls upon our membership to nominate members to serve on the GRSS Administrative Committee (AdCom). A nominating petition carrying a minimum of 2% of the names of eligible Society members (~70), excluding students, shall automatically place that nominee on the slate. Such nominations must be made by 30 April 2018. The Nominations Committee may choose to include a name on the slate regardless of the number of names generated by the nominating petition process. Prior to submission of a nomination petition, the petitioner shall have determined that the nominee named in the petition is willing to serve if elected; and evidence of such willingness to serve shall be submitted with the petition. Candidates must be current Members of the IEEE and the GRSS. Petition signatures can be submitted electronically through the Society website or by signing, scanning, and electronically mailing the pdf file of the paper petition. The name of each member signing the paper petition shall be clearly printed or typed. For identification purposes of signatures on paper petitions, membership numbers and addresses as listed in the official IEEE Membership records shall be included. Only signatures submitted electronically through the Society website or original signatures on paper petitions shall be accepted. Further information is provided here.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Presents the table of contents for this issue of the publication.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Presents a listing of the editorial board, board of governors, current staff, committee members, and/or society editors for this issue of the publication.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Presents the President’s message for this issue of the publication.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Prospective authors are requested to submit new, unpublished manuscripts for inclusion in the upcoming event described in this call for papers.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: The Lombardy Aerospace Industry Cluster [1] was founded in Italy in 2014 as the final step in constructing a representative institution for the regional system of aerospace industries. The process was initiated in 2009 with the first formal contacts between the local industry federation and the regional government of Lombardy, which led to the foundation of a provisional body (Distretto Aerospaziale Lombardo) in preparation for a more formalized industry cluster to come and in light of a mandate to represent the local aerospace industry politically.
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    Publication Date: 2018-04-04
    Description: Hyperspectral imagery contains hundreds of contiguous bands with a wealth of spectral signatures, making it possible to distinguish materials through subtle spectral discrepancies. Because these spectral bands are highly correlated, dimensionality reduction, as the name suggests, seeks to reduce data dimensionality without losing desirable information. This article reviews discriminant analysisbased dimensionality-reduction approaches for hyperspectral imagery, including typical linear discriminant analysis (LDA), state-of-the-art sparse graph-based discriminant analysis (SGDA), and their extensions.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Presents the introductory editorial for this issue of the publication.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Describes the above-named upcoming conference event. May include topics to be covered or calls for papers.
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    Publication Date: 2018-04-04
    Description: Graph algorithm is pervasive in many applications ranging from targeted advertising to natural language processing. Recently, Asynchronous Graph Processing (AGP) is becoming a promising model to support graph algorithm on large-scale distributed computing platforms because it enables faster convergence speed and lower synchronization cost than the synchronous model for no barrier between iterations. However, existing AGP methods still suffer from poor performance for inefficient vertex state propagation. In this paper, we propose an effective and low-cost forward and backward sweeping execution method to accelerate state propagation for AGP, based on a key observation that states in AGP can be propagated between vertices much faster when the vertices are processed sequentially along the graph path within each round. Through dividing graph into paths and asynchronously processing vertices on each path in an alternative forward and backward way according to their order on this path, vertex states in our approach can be quickly propagated to other vertices and converge in a faster way with only little additional overhead. In order to efficiently support it over distributed platforms, we also propose a scheme to reduce the communication overhead along with a static priority ordering scheme to further improve the convergence speed. Experimental results on a cluster with 1,024 cores show that our approach achieves excellent scalability for large-scale graph algorithms and the overall execution time is reduced by at least 39.8 percent, in comparison with the most cutting-edge methods.
    Print ISSN: 1041-4347
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    Publication Date: 2018-04-04
    Description: Deal selection on Groupon is a typical social learning and decision making process, where the quality of a deal is usually unknown to the customers. The customers must acquire this knowledge through social learning from other social medias such as reviews on Yelp. Additionally, the quality of a deal depends on both the state of the vendor and decisions of other customers on Groupon. How social learning and network externality affect the decisions of customers in deal selection on Groupon is our main interest. We develop a data-driven game-theoretic framework to understand the rational deal selection behaviors cross social medias. The sufficient condition of the Nash equilibrium is identified. A value-iteration algorithm is proposed to find the optimal deal selection strategy. We conduct a year-long experiment to trace the competitions among deals on Groupon and the corresponding Yelp ratings. We utilize the dataset to analyze the deal selection game with realistic settings. Finally, the performance of the proposed social learning framework is evaluated with real data. The results suggest that customers do make decisions in a rational way instead of following naive strategies, and there is still room to improve their decisions with assistance from the proposed framework.
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    Publication Date: 2018-04-04
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    Publication Date: 2018-04-04
    Description: Various perceptual domains have underlying compositional semantics that are rarely captured in current models. We suspect this is because directly learning the compositional structure has evaded these models. Yet, the compositional structure of a given domain can be grounded in a separate domain thereby simplifying its learning. To that end, we propose a new approach to modeling bimodal perceptual domains that explicitly relates distinct projections across each modality and then jointly learns a bimodal sparse representation. The resulting model enables compositionality across these distinct projections and hence can generalize to unobserved percepts spanned by this compositional basis. For example, our model can be trained on red triangles and blue squares ; yet, implicitly will also have learned red squares and blue triangles . The structure of the projections and hence the compositional basis is learned automatically; no assumption is made on the ordering of the compositional elements in either modality. Although our modeling paradigm is general, we explicitly focus on a tabletop building-blocks setting. To test our model, we have acquired a new bimodal dataset comprising images and spoken utterances of colored shapes (blocks) in the tabletop setting. Our experiments demonstrate the benefits of explicitly leveraging compositionality in both quantitative and human evaluation studies.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Building upon recent Deep Neural Network architectures, current approaches lying in the intersection of Computer Vision and Natural Language Processing have achieved unprecedented breakthroughs in tasks like automatic captioning or image retrieval. Most of these learning methods, though, rely on large training sets of images associated with human annotations that specifically describe the visual content. In this paper we propose to go a step further and explore the more complex cases where textual descriptions are loosely related to the images. We focus on the particular domain of news articles in which the textual content often expresses connotative and ambiguous relations that are only suggested but not directly inferred from images. We introduce an adaptive CNN architecture that shares most of the structure for multiple tasks including source detection, article illustration and geolocation of articles. Deep Canonical Correlation Analysis is deployed for article illustration, and a new loss function based on Great Circle Distance is proposed for geolocation. Furthermore, we present BreakingNews, a novel dataset with approximately 100K news articles including images, text and captions, and enriched with heterogeneous meta-data (such as GPS coordinates and user comments). We show this dataset to be appropriate to explore all aforementioned problems, for which we provide a baseline performance using various Deep Learning architectures, and different representations of the textual and visual features. We report very promising results and bring to light several limitations of current state-of-the-art in this kind of domain, which we hope will help spur progress in the field.
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  • 57
    Publication Date: 2018-04-04
    Description: Machine learning algorithms for the analysis of time-series often depend on the assumption that utilised data are temporally aligned. Any temporal discrepancies arising in the data is certain to lead to ill-generalisable models, which in turn fail to correctly capture properties of the task at hand. The temporal alignment of time-series is thus a crucial challenge manifesting in a multitude of applications. Nevertheless, the vast majority of algorithms oriented towards temporal alignment are either applied directly on the observation space or simply utilise linear projections-thus failing to capture complex, hierarchical non-linear representations that may prove beneficial, especially when dealing with multi-modal data (e.g., visual and acoustic information). To this end, we present Deep Canonical Time Warping (DCTW), a method that automatically learns non-linear representations of multiple time-series that are (i) maximally correlated in a shared subspace, and (ii) temporally aligned. Furthermore, we extend DCTW to a supervised setting, where during training, available labels can be utilised towards enhancing the alignment process. By means of experiments on four datasets, we show that the representations learnt significantly outperform state-of-the-art methods in temporal alignment, elegantly handling scenarios with heterogeneous feature sets, such as the temporal alignment of acoustic and visual information.
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    Publication Date: 2018-04-04
    Description: Domain adaptation between diverse source and target domains is challenging, especially in the real-world visual recognition tasks where the images and videos consist of significant variations in viewpoints, illuminations, qualities, etc. In this paper, we propose a new approach for domain generalization and domain adaptation based on exemplar SVMs. Specifically, we decompose the source domain into many subdomains, each of which contains only one positive training sample and all negative samples. Each subdomain is relatively less diverse, and is expected to have a simpler distribution. By training one exemplar SVM for each subdomain, we obtain a set of exemplar SVMs. To further exploit the inherent structure of source domain, we introduce a nuclear-norm based regularizer into the objective function in order to enforce the exemplar SVMs to produce a low-rank output on training samples. In the prediction process, the confident exemplar SVM classifiers are selected and reweigted according to the distribution mismatch between each subdomain and the test sample in the target domain. We formulate our approach based on the logistic regression and least square SVM algorithms, which are referred to as low rank exemplar SVMs (LRE-SVMs) and low rank exemplar least square SVMs (LRE-LSSVMs), respectively. A fast algorithm is also developed for accelerating the training of LRE-LSSVMs. We further extend Domain Adaptation Machine (DAM) to learn an optimal target classifier for domain adaptation, and show that our approach can also be applied to domain adaptation with evolving target domain, where the target data distribution is gradually changing. The comprehensive experiments for object recognition and action recognition demonstrate the effectiveness of our approach for domain generalization and domain adaptation with fixed and evolving target domains.
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    Publication Date: 2018-04-04
    Description: In content-based image retrieval, SIFT feature and the feature from deep convolutional neural network (CNN) have demonstrated promising performance. To fully explore both visual features in a unified framework for effective and efficient retrieval, we propose a collaborative index embedding method to implicitly integrate the index matrices of them. We formulate the index embedding as an optimization problem from the perspective of neighborhood sharing and solve it with an alternating index update scheme. After the iterative embedding, only the embedded CNN index is kept for on-line query, which demonstrates significant gain in retrieval accuracy, with very economical memory cost. Extensive experiments have been conducted on the public datasets with million-scale distractor images. The experimental results reveal that, compared with the recent state-of-the-art retrieval algorithms, our approach achieves competitive accuracy performance with less memory overhead and efficient query computation.
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    Publication Date: 2018-04-04
    Description: In this paper, we propose a context-aware local binary feature learning (CA-LBFL) method for face recognition. Unlike existing learning-based local face descriptors such as discriminant face descriptor (DFD) and compact binary face descriptor (CBFD) which learn each feature code individually, our CA-LBFL exploits the contextual information of adjacent bits by constraining the number of shifts from different binary bits, so that more robust information can be exploited for face representation. Given a face image, we first extract pixel difference vectors (PDV) in local patches, and learn a discriminative mapping in an unsupervised manner to project each pixel difference vector into a context-aware binary vector. Then, we perform clustering on the learned binary codes to construct a codebook, and extract a histogram feature for each face image with the learned codebook as the final representation. In order to exploit local information from different scales, we propose a context-aware local binary multi-scale feature learning (CA-LBMFL) method to jointly learn multiple projection matrices for face representation. To make the proposed methods applicable for heterogeneous face recognition, we present a coupled CA-LBFL (C-CA-LBFL) method and a coupled CA-LBMFL (C-CA-LBMFL) method to reduce the modality gap of corresponding heterogeneous faces in the feature level, respectively. Extensive experimental results on four widely used face datasets clearly show that our methods outperform most state-of-the-art face descriptors.
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    Publication Date: 2018-04-04
    Description: Single modality action recognition on RGB or depth sequences has been extensively explored recently. It is generally accepted that each of these two modalities has different strengths and limitations for the task of action recognition. Therefore, analysis of the RGB+D videos can help us to better study the complementary properties of these two types of modalities and achieve higher levels of performance. In this paper, we propose a new deep autoencoder based shared-specific feature factorization network to separate input multimodal signals into a hierarchy of components. Further, based on the structure of the features, a structured sparsity learning machine is proposed which utilizes mixed norms to apply regularization within components and group selection between them for better classification performance. Our experimental results show the effectiveness of our cross-modality feature analysis framework by achieving state-of-the-art accuracy for action classification on five challenging benchmark datasets.
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    Publication Date: 2018-04-04
    Description: Recently, cross-modal search has attracted considerable attention but remains a very challenging task because of the integration complexity and heterogeneity of the multi-modal data. To address both challenges, in this paper, we propose a novel method termed hetero-manifold regularisation (HMR) to supervise the learning of hash functions for efficient cross-modal search. A hetero-manifold integrates multiple sub-manifolds defined by homogeneous data with the help of cross-modal supervision information. Taking advantages of the hetero-manifold, the similarity between each pair of heterogeneous data could be naturally measured by three order random walks on this hetero-manifold. Furthermore, a novel cumulative distance inequality defined on the hetero-manifold is introduced to avoid the computational difficulty induced by the discreteness of hash codes. By using the inequality, cross-modal hashing is transformed into a problem of hetero-manifold regularised support vector learning. Therefore, the performance of cross-modal search can be significantly improved by seamlessly combining the integrated information of the hetero-manifold and the strong generalisation of the support vector machine. Comprehensive experiments show that the proposed HMR achieve advantageous results over the state-of-the-art methods in several challenging cross-modal tasks.
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  • 63
    Publication Date: 2018-04-04
    Description: We propose Multi-Task Learning with Low Rank Attribute Embedding (MTL-LORAE) to address the problem of person re-identification on multi-cameras. Re-identifications on different cameras are considered as related tasks, which allows the shared information among different tasks to be explored to improve the re-identification accuracy. The MTL-LORAE framework integrates low-level features with mid-level attributes as the descriptions for persons. To improve the accuracy of such description, we introduce the low-rank attribute embedding, which maps original binary attributes into a continuous space utilizing the correlative relationship between each pair of attributes. In this way, inaccurate attributes are rectified and missing attributes are recovered. The resulting objective function is constructed with an attribute embedding error and a quadratic loss concerning class labels. It is solved by an alternating optimization strategy. The proposed MTL-LORAE is tested on four datasets and is validated to outperform the existing methods with significant margins.
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  • 64
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
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  • 65
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: In the early days, content-based image retrieval (CBIR) was studied with global features. Since 2003, image retrieval based on local descriptors ( de facto SIFT) has been extensively studied for over a decade due to the advantage of SIFT in dealing with image transformations. Recently, image representations based on the convolutional neural network (CNN) have attracted increasing interest in the community and demonstrated impressive performance. Given this time of rapid evolution, this article provides a comprehensive survey of instance retrieval over the last decade. Two broad categories, SIFT-based and CNN-based methods, are presented. For the former, according to the codebook size, we organize the literature into using large/medium-sized/small codebooks. For the latter, we discuss three lines of methods, i.e., using pre-trained or fine-tuned CNN models, and hybrid methods. The first two perform a single-pass of an image to the network, while the last category employs a patch-based feature extraction scheme. This survey presents milestones in modern instance retrieval, reviews a broad selection of previous works in different categories, and provides insights on the connection between SIFT and CNN-based methods. After analyzing and comparing retrieval performance of different categories on several datasets, we discuss promising directions towards generic and specialized instance retrieval.
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  • 66
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: This paper proposes a method for line segment detection in digital images. We propose a novel linelet-based representation to model intrinsic properties of line segments in rasterized image space. Based on this, line segment detection, validation, and aggregation frameworks are constructed. For a numerical evaluation on real images, we propose a new benchmark dataset of real images with annotated lines called YorkUrban-LineSegment. The results show that the proposed method outperforms state-of-the-art methods numerically and visually. To our best knowledge, this is the first report of numerical evaluation of line segment detection on real images.
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  • 67
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: This paper introduces a fast and efficient segmentation technique for 2D images and 3D point clouds of building facades. Facades of buildings are highly structured and consequently most methods that have been proposed for this problem aim to make use of this strong prior information. Contrary to most prior work, we are describing a system that is almost domain independent and consists of standard segmentation methods. We train a sequence of boosted decision trees using auto-context features. This is learned using stacked generalization. We find that this technique performs better, or comparable with all previous published methods and present empirical results on all available 2D and 3D facade benchmark datasets. The proposed method is simple to implement, easy to extend, and very efficient at test-time inference.
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  • 68
    Publication Date: 2018-04-04
    Description: A minimum hybridization network is a rooted phylogenetic network that displays two given rooted phylogenetic trees using a minimum number of reticulations. Previous mathematical work on their calculation has usually assumed the input trees to be bifurcating, correctly rooted, or that they both contain the same taxa. These assumptions do not hold in biological studies and “realistic” trees have multifurcations, are difficult to root, and rarely contain the same taxa. We present a new algorithm for computing minimum hybridization networks for a given pair of “realistic” rooted phylogenetic trees. We also describe how the algorithm might be used to improve the rooting of the input trees. We introduce the concept of “autumn trees”, a nice framework for the formulation of algorithms based on the mathematics of “maximum acyclic agreement forests”. While the main computational problem is hard, the run-time depends mainly on how different the given input trees are. In biological studies, where the trees are reasonably similar, our parallel implementation performs well in practice. The algorithm is available in our open source program Dendroscope 3, providing a platform for biologists to explore rooted phylogenetic networks. We demonstrate the utility of the algorithm using several previously studied data sets.
    Print ISSN: 1545-5963
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    Topics: Biology , Computer Science
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  • 69
    Publication Date: 2018-04-04
    Description: The human colorectal carcinoma cell line (Caco-2) is a commonly used in-vitro test that predicts the absorption potential of orally administered drugs. In-silico prediction methods, based on the Caco-2 assay data, may increase the effectiveness of the high-throughput screening of new drug candidates. However, previously developed in-silico models that predict the Caco-2 cellular permeability of chemical compounds use handcrafted features that may be dataset-specific and induce over-fitting problems. Deep Neural Network (DNN) generates high-level features based on non-linear transformations for raw features, which provides high discriminant power and, therefore, creates a good generalized model. We present a DNN-based binary Caco-2 permeability classifier. Our model was constructed based on 663 chemical compounds with in-vitro Caco-2 apparent permeability data. Two hundred nine molecular descriptors are used for generating the high-level features during DNN model generation. Dropout regularization is applied to solve the over-fitting problem and the non-linear activation. The Rectified Linear Unit (ReLU) is adopted to reduce the vanishing gradient problem. The results demonstrate that the high-level features generated by the DNN are more robust than handcrafted features for predicting the cellular permeability of structurally diverse chemical compounds in Caco-2 cell lines.
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    Topics: Biology , Computer Science
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  • 70
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Read trimming is a fundamental first step of the analysis of next generation sequencing (NGS) data. Traditionally, it is performed heuristically, and algorithmic work in this area has been neglected. Here, we address this topic and formulate three optimization problems for block-based trimming (truncating the same low-quality positions at both ends for all reads and removing low-quality truncated reads). We find that all problems are NP-hard. Hence, we investigate the approximability of the problems. Two of them are NP-hard to approximate. However, the non-random distribution of quality scores in NGS data sets makes it tempting to speculate that quality constraints for read positions are typically satisfied by fulfilling quality constraints for reads. Thus, we propose three relaxed problems and develop efficient polynomial-time algorithms for them including heuristic speed-up techniques and parallelizations. We apply these optimized block trimming algorithms to 12 data sets from three species, four sequencers, and read lengths ranging from 36 to 101 bp and find that (i) the omitted constraints are indeed almost always satisfied, (ii) the optimized read trimming algorithms typically yield a higher number of untrimmed bases than traditional heuristics, and (iii) these results can be generalized to alternative objective functions beyond counting the number of untrimmed bases.
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    Topics: Biology , Computer Science
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  • 71
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Advances in de novo synthesis of DNA and computational gene design methods make possible the customization of genes by direct manipulation of features such as codon bias and mRNA secondary structure. Codon context is another feature significantly affecting mRNA translational efficiency, but existing methods and tools for evaluating and designing novel optimized protein coding sequences utilize untested heuristics and do not provide quantifiable guarantees on design quality. In this study we examine statistical properties of codon context measures in an effort to better understand the phenomenon. We analyze the computational complexity of codon context optimization and design exact and efficient heuristic gene recoding algorithms under reasonable constraint models. We also present a web-based tool for evaluating codon context bias in the appropriate context.
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    Topics: Biology , Computer Science
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  • 72
    Publication Date: 2018-04-04
    Description: To assess the genetic diversity of an environmental sample in metagenomics studies, the amplicon sequences of 16s rRNA genes need to be clustered into operational taxonomic units (OTUs). Many existing tools for OTU clustering trade off between accuracy and computational efficiency. We propose a novel OTU clustering algorithm, hc-OTU, which achieves high accuracy and fast runtime by exploiting homopolymer compaction and k-mer profiling to significantly reduce the computing time for pairwise distances of amplicon sequences. We compare the proposed method with other widely used methods, including UCLUST, CD-HIT, MOTHUR, ESPRIT, ESPRIT-TREE, and CLUSTOM, comprehensively, using nine different experimental datasets and many evaluation metrics, such as normalized mutual information, adjusted Rand index, measure of concordance, and F-score. Our evaluation reveals that the proposed method achieves a level of accuracy comparable to the respective accuracy levels of MOTHUR and ESPRIT-TREE, two widely used OTU clustering methods, while delivering orders-of-magnitude speedups.
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    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 73
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Recent studies have suggested abnormal brain network organization in subjects with Autism Spectrum Disorders (ASD). Here we applied spectral clustering algorithm, diverse centrality measures (betweenness (BC), clustering (CC), eigenvector (EC), and degree (DC)), and also the network entropy (NE) to identify brain sub-systems associated with ASD. We have found that BC increases in the following ASD clusters: in the somatomotor, default-mode, cerebellar, and fronto-parietal. On the other hand, CC, EC, and DC decrease in the somatomotor, default-mode, and cerebellar clusters. Additionally, NE decreases in ASD in the cerebellar cluster. These findings reinforce the hypothesis of under-connectivity in ASD and suggest that the difference in the network organization is more prominent in the cerebellar system. The cerebellar cluster presents reduced NE in ASD, which relates to a more regular organization of the networks. These results might be important to improve current understanding about the etiological processes and the development of potential tools supporting diagnosis and therapeutic interventions.
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  • 74
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Probabilistic models have been successfully adopted in computational biology and bioinformatics. Recently, a number of powerful probabilistic models and methods have been developed in the field of computational neuroscience, and these effective models have significantly advanced this field. This special section aims to capture some snapshots of recent developments of probabilistic methods in the synergistic combinations of cognitive brain science, brain imaging, and neuroscience. It aims to report the latest advances in these fields to the research community working on probabilistic methods in brain imaging analysis and computational neuroscience. This special section includes five contributed articles.
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  • 75
    Publication Date: 2018-04-04
    Description: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized clinically by motor dysfunction (bradykinesia, rigidity, tremor, and postural instability), and pathologically by the loss of dopaminergic neurons in the substantia nigra of the basal ganglia. Growing literature supports that cognitive deficits may also be present in PD, even in non-demented patients. Gray matter (GM) atrophy has been reported in PD and may be related to cognitive decline. This study investigated cortical thickness in non-demented PD subjects and elucidated its relationship to cognitive impairment using high-resolution T1-weighted brain MRI and comprehensive cognitive function scores from 71 non-demented PD and 48 control subjects matched for age, gender, and education. Cortical thickness was compared between groups using a flexible hierarchical multivariate Bayesian model, which accounts for correlations between brain regions. Correlation analyses were performed among brain areas and cognitive domains as well, which showed significant group differences in the PD population. Compared to Controls, PD subjects demonstrated significant age-adjusted cortical thinning predominantly in inferior and superior parietal areas and extended to superior frontal, superior temporal, and precuneus areas (posterior probability >0.9). Cortical thinning was also found in the left precentral and lateral occipital, and right postcentral, middle frontal, and fusiform regions (posterior probability >0.9). PD patients showed significantly reduced cognitive performance in executive function, including set shifting (p = 0.005) and spontaneous flexibility (p = 0.02), which were associated with the above cortical thinning regions (p 〈 0.05).
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  • 76
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-03-06
    Description: Super resolving a low-resolution video, namely video super-resolution (SR), is usually handled by either single-image SR or multi-frame SR. Single-Image SR deals with each video frame independently, and ignores intrinsic temporal dependency of video frames which actually plays a very important role in video SR. Multi-Frame SR generally extracts motion information, e.g., optical flow, to model the temporal dependency, but often shows high computational cost. Considering that recurrent neural networks (RNNs) can model long-term temporal dependency of video sequences well, we propose a fully convolutional RNN named bidirectional recurrent convolutional network for efficient multi-frame SR. Different from vanilla RNNs, 1) the commonly-used full feedforward and recurrent connections are replaced with weight-sharing convolutional connections. So they can greatly reduce the large number of network parameters and well model the temporal dependency in a finer level, i.e., patch-based rather than frame-based, and 2) connections from input layers at previous timesteps to the current hidden layer are added by 3D feedforward convolutions, which aim to capture discriminate spatio-temporal patterns for short-term fast-varying motions in local adjacent frames. Due to the cheap convolutional operations, our model has a low computational complexity and runs orders of magnitude faster than other multi-frame SR methods. With the powerful temporal dependency modeling, our model can super resolve videos with complex motions and achieve well performance.
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  • 77
    Publication Date: 2018-03-06
    Description: Human faces in surveillance videos often suffer from severe image blur, dramatic pose variations, and occlusion. In this paper, we propose a comprehensive framework based on Convolutional Neural Networks (CNN) to overcome challenges in video-based face recognition (VFR). First, to learn blur-robust face representations, we artificially blur training data composed of clear still images to account for a shortfall in real-world video training data. Using training data composed of both still images and artificially blurred data, CNN is encouraged to learn blur-insensitive features automatically. Second, to enhance robustness of CNN features to pose variations and occlusion, we propose a Trunk-Branch Ensemble CNN model (TBE-CNN), which extracts complementary information from holistic face images and patches cropped around facial components. TBE-CNN is an end-to-end model that extracts features efficiently by sharing the low- and middle-level convolutional layers between the trunk and branch networks. Third, to further promote the discriminative power of the representations learnt by TBE-CNN, we propose an improved triplet loss function. Systematic experiments justify the effectiveness of the proposed techniques. Most impressively, TBE-CNN achieves state-of-the-art performance on three popular video face databases: PaSC, COX Face, and YouTube Faces. With the proposed techniques, we also obtain the first place in the BTAS 2016 Video Person Recognition Evaluation.
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  • 78
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    Publication Date: 2018-04-04
    Description: The Constellation of Small Satellites for the Mediterranean Basin Observation (COSMO)-SkyMed Second Generation (CSG) ground segment (GS) is based on an interoperable and multimission design that provides CSG functionalities to external partners and access through the CSG to services belonging to other Earth observation (EO) partners. Moreover, the CSG GS design supports such cooperation by expansion through replication of user GSs (UGSs) in different ways. In this manner, the CSG GS is able to manage EO foreign missions by providing centralized and multimission access in an integrated environment, thus offering valuable technological solutions to the defense and civilian communities. This article provides an indepth description of the CSG system access portfolio, focusing on the architectural details of the GS that allow the provisioning and exploitation of the CSG's interoperability, expandability, and multisensor/multimission (IEM) features.
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    Topics: Architecture, Civil Engineering, Surveying , Electrical Engineering, Measurement and Control Technology , Geosciences , Computer Science
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  • 79
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Describes the above-named upcoming conference event. May include topics to be covered or calls for papers.
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  • 80
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Presents information on various GRSS Society chapters.
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  • 81
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Presents information on various GRSS Society chapters.
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  • 82
    Publication Date: 2018-04-04
    Description: The Global Learning and Observations to Benefit the Environment (GLOBE) program is a worldwide hands-on primary and secondary school-based science and education program. GLOBE’s vision promotes and supports collaboration among students, teachers, and scientists on inquiry-based investigations of the environment and the Earth system, working in close partnership with NASA, the National Oceanic and Atmospheric Administration (NOAA), and the National Science Foundation (NSF) Earth System Science Projects for study and research about the dynamics of Earth’s environment.
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  • 83
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Presents information on the PIERS 2018 conference.
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  • 84
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Presents information on the 2018 IEEE GRSS Data Fusion Contest.
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  • 85
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Presents the GRSS society calendar of upcoming events.
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  • 86
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    Publication Date: 2018-04-04
    Description: RSCL is a publication of IEEE GRSS, just like the GRSS Transactions and the GRSS Newsletter, but its currency is computer codes associated with one or more aspect of geoscience remote sensing. For more information, contact the RSCL Editor.
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  • 87
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: RDF question/answering (Q/A) allows users to ask questions in natural languages over a knowledge base represented by RDF. To answer a natural language question, the existing work takes a two-stage approach: question understanding and query evaluation. Their focus is on question understanding to deal with the disambiguation of the natural language phrases. The most common technique is the joint disambiguation, which has the exponential search space. In this paper, we propose a systematic framework to answer natural language questions over RDF repository (RDF Q/A) from a graph data-driven perspective. We propose a semantic query graph to model the query intention in the natural language question in a structural way, based on which, RDF Q/A is reduced to subgraph matching problem. More importantly, we resolve the ambiguity of natural language questions at the time when matches of query are found. The cost of disambiguation is saved if there are no matching found. More specifically, we propose two different frameworks to build the semantic query graph, one is relation (edge)-first and the other one is node-first. We compare our method with some state-of-the-art RDF Q/A systems in the benchmark dataset. Extensive experiments confirm that our method not only improves the precision but also speeds up query performance greatly.
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  • 88
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    Publication Date: 2018-04-04
    Description: Spatial clustering deals with the unsupervised grouping of places into clusters and finds important applications in urban planning and marketing. Current spatial clustering models disregard information about the people and the time who and when are related to the clustered places. In this paper, we show how the density-based clustering paradigm can be extended to apply on places which are visited by users of a geo-social network. Our model considers spatio-temporal information and the social relationships between users who visit the clustered places. After formally defining the model and the distance measure it relies on, we provide alternatives to our model and the distance measure. We evaluate the effectiveness of our model via a case study on real data; in addition, we design two quantitative measures, called social entropy and community score, to evaluate the quality of the discovered clusters. The results show that temporal-geo-social clusters have special properties and cannot be found by applying simple spatial clustering approaches and other alternatives.
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  • 89
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Semantic drift is a common problem in iterative information extraction. Previous approaches for minimizing semantic drift may incur substantial loss in recall. We observe that most semantic drifts are introduced by a small number of questionable extractions in the earlier rounds of iterations. These extractions subsequently introduce a large number of questionable results, which lead to the semantic drift phenomenon. We call these questionable extractions Drifting Points (DPs). If erroneous extractions are the “symptoms” of semantic drift, then DPs are the “causes” of semantic drift. In this paper, we propose a method to minimize semantic drift by identifying the DPs and removing the effect introduced by the DPs. We use isA (concept-instance) extraction as an example to describe our approach in cleaning information extraction errors caused by semantic drift, but we perform experiments on different relation extraction processes on three large real data extraction collections. The experimental results show that our DP cleaning method enables us to clean around 90 percent incorrect instances or patterns with about 90 percent precision, which outperforms the previous approaches we compare with.
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  • 90
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    Publication Date: 2018-04-04
    Description: Graphs are used for representing and understanding objects and their relationships for numerous applications such as social networks, Semantic Webs, and biological networks. Integrity assurance of data and query results for graph databases is an essential security requirement. In this paper, we propose two efficient integrity verification schemes—HMACs for graphs (gHMAC) for two-party data sharing, and redactable HMACs for graphs (rgHMAC) for third-party data sharing, such as a cloud-based graph database service. We compute one HMAC value for both the schemes and two other verification objects for rgHMAC scheme that are shared with the verifier. We show that the proposed schemes are provably secure with respect to integrity attacks on the structure and/or content of graphs and query results. The proposed schemes have linear complexity in terms of the number of vertices and edges in the graphs, which is shown to be optimal. Our experimental results corroborate that the proposed HMAC-based schemes for graphs are highly efficient as compared to the digital signature-based schemes—computation of HMAC tags is about 10 times faster than the computation of digital signatures.
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  • 91
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Reliable propagation of information through large networks, e.g., communication networks, social networks, or sensor networks is very important in many applications concerning marketing, social networks, and wireless sensor networks. However, social ties of friendship may be obsolete, and communication links may fail, inducing the notion of uncertainty in such networks. In this paper, we address the problem of optimizing information propagation in uncertain networks given a constrained budget of edges. We show that this problem requires to solve two NP-hard subproblems: the computation of expected information flow, and the optimal choice of edges. To compute the expected information flow to a source vertex, we propose the F-tree as a specialized data structure, that identifies independent components of the graph for which the information flow can either be computed analytically and efficiently, or for which traditional Monte-Carlo sampling can be applied independently of the remaining network. For the problem of finding the optimal edges, we propose a series of heuristics that exploit properties of this data structure. Our evaluation shows that these heuristics lead to high quality solutions, thus yielding high information flow, while maintaining low running time.
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  • 92
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Business to Business (B2B) marketing aims at meeting the needs of other businesses instead of individual consumers, and thus entails management of more complex business needs than consumer marketing. The buying processes of the business customers involve series of different marketing campaigns providing multifaceted information about the products or services. While most existing studies focus on individual consumers, little has been done to guide business customers due to the dynamic and complex nature of these business buying processes. To this end, in this paper, we focus on providing a unified view of social and temporal modeling for B2B marketing campaign recommendation. Along this line, we first exploit the temporal behavior patterns in the B2B buying processes and develop a marketing campaign recommender system. Specifically, we start with constructing a temporal graph as the knowledge representation of the buying process of each business customer. Temporal graph can effectively extract and integrate the campaign order preferences of individual business customers. It is also worth noting that our system is backward compatible since the participating frequency used in conventional static recommender systems is naturally embedded in our temporal graph. The campaign recommender is then built in a low-rank graph reconstruction framework based on probabilistic graphical models. Our framework can identify the common graph patterns and predict missing edges in the temporal graphs. In addition, since business customers very often have different decision makers from the same company, we also incorporate social factors, such as community relationships of the business customers, for further improving overall performances of the missing edge prediction and recommendation. Finally, we have performed extensive empirical studies on real-world B2B marketing data sets and the results show that the proposed method can effectively improve the quality of the campaign recommendat- ons for challenging B2B marketing tasks.
    Print ISSN: 1041-4347
    Electronic ISSN: 1558-2191
    Topics: Computer Science
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  • 93
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: In this paper, we propose a prototype-based classification model for evolving data streams, called SyncStream, which allows dynamically modeling time-changing concepts, making predictions in a local fashion. Instead of learning a single model on a fixed or adaptive sliding window of historical data or ensemble learning a set of weighted base classifiers, SyncStream captures evolving concepts by dynamically maintaining a set of prototypes in a proposed P-Tree, which are obtained based on the error-driven representativeness learning and synchronization-inspired constrained clustering. To identify abrupt concept drifts in data streams, PCA and statistical analysis based heuristic approaches have been introduced. To further learn the associations among distributed data streams, the extended P-Tree structure and KNN-style strategy are introduced. We demonstrate that our new data stream classification approach has several attractive benefits: (a) SyncStream is capable of dynamically modeling the evolving concepts from even a small set of prototypes. (b) Owing to synchronization-based constrained clustering and P-Tree, SyncStream supports efficient and effective data representation and maintenance. (c) SyncStream is also tolerant of inappropriate or noisy examples via error-driven representativeness learning. (d) SyncStream allows learning relationship among distributed data streams at the instance level. The experimental results indicate its efficiency and effectiveness.
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  • 94
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Community search is important in graph analysis and can be used in many real applications. In the literature, various community models have been proposed. However, most of them cannot well identify the overlaps between communities which is an essential feature of real graphs. To address this issue, the $k$ -clique percolation community model was proposed and has been proven effective in many applications. Motivated by this, in this paper, we adopt the $k$ -clique percolation community model and study the densest clique percolation community search problem which aims to find the $k$ -clique percolation community with the maximum $k$ value that contains a given set of query nodes. We adopt an index-based approach to solve this problem. Based on the observation that a $k$ -clique percolation community is a union of maximal cliques, we devise a novel compact index, $mathsf {DCPC}$ - $mathsf {Index}$ , to preserve the max- mal cliques and their connectivity information of the input graph. With $mathsf {DCPC}$ - $mathsf {Index}$ , we can answer the densest clique percolation community query efficiently. Besides, we also propose an index construction algorithm based on the definition of $mathsf {DCPC}$ - $mathsf {Index}$ and further improve the algorithm in terms of efficiency and memory consumption. We conduct extensive performance studies on real graphs and the experimental results demonstrate the efficiency of our index-based query processing algorithm and index construction algorithm.
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  • 95
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: The class imbalance problem in machine learning occurs when certain classes are underrepresented relative to the others, leading to a learning bias toward the majority classes. To cope with the skewed class distribution, many learning methods featuring minority oversampling have been proposed, which are proved to be effective. To reduce information loss during feature space projection, this study proposes a novel oversampling algorithm, named minority oversampling in kernel adaptive subspaces (MOKAS), which exploits the invariant feature extraction capability of a kernel version of the adaptive subspace self-organizing maps. The synthetic instances are generated from well-trained subspaces and then their pre-images are reconstructed in the input space. Additionally, these instances characterize nonlinear structures present in the minority class data distribution and help the learning algorithms to counterbalance the skewed class distribution in a desirable manner. Experimental results on both real and synthetic data show that the proposed MOKAS is capable of modeling complex data distribution and outperforms a set of state-of-the-art oversampling algorithms.
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  • 96
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: In this paper, we study a novel variant of obstructed nearest neighbor queries, namely, range-based obstructed nearest neighbor (RONN) search. As a natural generalization of continuous obstructed nearest-neighbor (CONN), an RONN query retrieves a set of obstructed nearest neighbors corresponding to every point in a specified range. We propose a new index, namely binary obstructed tree (called OB-tree ), for indexing complex objects in the obstructed space. The novelty of OB-tree lies in the idea of dividing the obstructed space into non-obstructed subspaces , aiming to efficiently retrieve highly qualified candidates for RONN processing. We develop an algorithm for construction of the OB-tree and propose a space division scheme, called optimal obstacle balance (OOB2) scheme, to address the tree balance problem. Accordingly, we propose an efficient algorithm, called RONN by OB-tree Acceleration (RONN-OBA), which exploits the OB-tree and a binary traversal order of data objects to accelerate query processing of RONN. In addition, we extend our work in several aspects regarding the shape of obstacles, and range-based $k$ NN queries in obstructed space. At last, we conduct a comprehensive performance evaluation using both real and synthetic datasets to validate our ideas and the proposed algorithms. The experimental result shows that the RONN-OBA algorithm outperforms the two R-tree based algorithms and RONN-OA significantly.
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  • 97
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Existing graph classification usually relies on an exhaustive enumeration of substructure patterns, where the number of substructures expands exponentially w.r.t. with the size of the graph set. Recently, the Weisfeiler-Lehman (WL) graph kernel has achieved the best performance in terms of both accuracy and efficiency among state-of-the-art methods. However, it is still time-consuming, especially for large-scale graph classification tasks. In this paper, we present a -Ary Tree based Hashing (KATH) algorithm, which is able to obtain competitive accuracy with a very fast runtime. The main idea of KATH is to construct a traversal table to quickly approximate the subtree patterns in WL using $K$ -ary trees. Based on the traversal table, KATH employs a recursive indexing process that performs only $r$ times of matrix indexing to generate all $(r-1)$ -depth $K$ -ary trees, where the leaf node labels of a tree can uniquely specify the pattern. After that, the MinHash scheme is used to fingerprint the acquired subtree patterns for a graph. Our experimental results on both real world and synthetic data sets show that KATH runs significantly faster than state-of-the-art methods while achieving competitive or better accuracy.
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  • 98
    Publication Date: 2018-04-04
    Description: This special section of the IEEE/ACM Transactions on Computational Biology and Bioinformatics contains extended versions of the best papers presented at the First International Conference on Algorithms for Computational Biology (AlCoB 2014). Out of 39 submissions to the conference, only four papers representing the current state-of-the-art in their respective domains were accepted to this special section.
    Print ISSN: 1545-5963
    Electronic ISSN: 1557-9964
    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 99
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: Genome Rearrangements are large-scale mutational events that affect genomes during the evolutionary process. Therefore, these mutations differ from punctual mutations. They can move genes from one place to the other, change the orientation of some genes, or even change the number of chromosomes. In this work, we deal with inversion events which occur when a segment of DNA sequence in the genome is reversed. In our model, each inversion costs the number of elements in the reversed segment. We present a new algorithm for this problem based on the metaheuristic called Greedy Randomized Adaptive Search Procedure (GRASP) that has been routinely used to find solutions for combinatorial optimization problems. In essence, we implemented an iterative process in which each iteration receives a feasible solution whose neighborhood is investigated. Our analysis shows that we outperform any other approach by significant margin. We also use our algorithm to build phylogenetic trees for a subset of species in the Yersinia genus and we compared our trees to other results in the literature.
    Print ISSN: 1545-5963
    Electronic ISSN: 1557-9964
    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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  • 100
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018-04-04
    Description: The endoplasmic reticulum (ER) is an intricate network that pervades the entire cortex of plant cells and its geometric shape undergoes drastic changes. This paper proposes a mathematical model to reconstruct geometric network dynamics by combining the node movements within the network and topological changes engendered by these nodes. The network topology in the model is determined by a modified optimization procedure from the work (Lemarchand, et al. 2014) which minimizes the total length taking into account both degree and angle constraints, beyond the conditions of connectedness and planarity. A novel feature for solving our optimization problem is the use of “lifted” angle constraints, which allows one to considerably reduce the solution runtimes. Using this optimization technique and a Langevin approach for the branching node movement, the simulated network dynamics represent the ER network dynamics observed under latrunculin B treated condition and recaptures features such as the appearance/disappearance of loops within the ER under the native condition. The proposed modeling approach allows quantitative comparison of networks between the model and experimental data based on topological changes induced by node dynamics. An increased temporal resolution of experimental data will allow a more detailed comparison of network dynamics using this modeling approach.
    Print ISSN: 1545-5963
    Electronic ISSN: 1557-9964
    Topics: Biology , Computer Science
    Published by Institute of Electrical and Electronics Engineers (IEEE) on behalf of The IEEE Computational Intelligence Society ; The IEEE Computer Society ; The IEEE Control Systems Society ; The IEEE Engineering in Medicine and Biology Society ; The Association for Computing Machinery.
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