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An H-NS-like Stealth Protein Aids Horizontal DNA Transmission in Bacteria (2007)

Doyle, Marie ; Fookes, Maria ; Ivens, Al ; [weitere]

American Association for the Advancement of Science

In: Science. 2007; 315(5809): 251-252. Published 2007 Jan 12. doi: 10.1126/science.1137550.

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Publikationsdatum: 2007-01-12

Beschreibung: The Sfh protein is encoded by self-transmissible plasmids involved in human typhoid and is closely related to the global regulator H-NS. We have found that Sfh provides a stealth function that allows the plasmids to be transmitted to new bacterial hosts with minimal effects on their fitness. Introducing the plasmid without thesfhgene imposes a mild H-NS–phenotype and a severe loss of fitness due to titration of the cellular pool of H-NS by the A+T-rich plasmid. This stealth strategy seems to be used widely to aid horizontal DNA transmission and has important implications for bacterial evolution.

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science

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In SYNC: The Ins and Outs of Circadian Oscillations in Calcium (2007)

Imaizumi, T. ; Schroeder, J. I. ; Kay, S. A.

American Association for the Advancement of Science

In: Science Signaling. 2007; 2007(390): pe32-pe32. Published 2007 Jun 06. doi: 10.1126/stke.3902007pe32.

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Publikationsdatum: 2007-06-06

Print ISSN: 1945-0877

Digitale ISSN: 1937-9145

Thema: Biologie , Medizin

Publiziert von American Association for the Advancement of Science

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Proteasome-Independent Functions of Ubiquitin in Endocytosis and Signaling (2007)

Mukhopadhyay, Debdyuti ; Riezman, Howard

American Association for the Advancement of Science

In: Science. 2007; 315(5809): 201-205. Published 2007 Jan 12. doi: 10.1126/science.1127085.

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Publikationsdatum: 2007-01-12

Beschreibung: Ubiquitination is a reversible posttranslational modification of cellular proteins, in which a 76–amino acid polypeptide, ubiquitin, is primarily attached to the ϵ-amino group of lysines in target proteins. Ubiquitination is a major player in regulating a broad host of cellular processes, including cell division, differentiation, signal transduction, protein trafficking, and quality control. Aberrations in the ubiquitination system are implicated in pathogenesis of some diseases, certain malignancies, neurodegenerative disorders, and pathologies of the inflammatory immune response. Here, we discuss the proteasome-independent roles of ubiquitination in signaling and endocytosis.

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science

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Probing Rényi entanglement entropy via randomized measurements (2019)

Brydges, Tiff ; Elben, Andreas ; Jurcevic, Petar ; [weitere]

American Association for the Advancement of Science

In: Science. 2019; 364(6437): 260-263. Published 2019 Apr 18. doi: 10.1126/science.aau4963.

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Publikationsdatum: 2019-04-18

Beschreibung: Entanglement is a key feature of many-body quantum systems. Measuring the entropy of different partitions of a quantum system provides a way to probe its entanglement structure. Here, we present and experimentally demonstrate a protocol for measuring the second-order Rényi entropy based on statistical correlations between randomized measurements. Our experiments, carried out with a trapped-ion quantum simulator with partition sizes of up to 10 qubits, prove the overall coherent character of the system dynamics and reveal the growth of entanglement between its parts, in both the absence and presence of disorder. Our protocol represents a universal tool for probing and characterizing engineered quantum systems in the laboratory, which is applicable to arbitrary quantum states of up to several tens of qubits.

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science

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