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  • Q1-390  (1,698)
  • H1-99  (1,299)
  • Fisheries
  • Inorganic Chemistry
  • Organic Chemistry
  • Polymer and Materials Science
  • 2020-2024  (2,992)
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  • 1
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 2
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    Département des études, de la prospective et des statistiques
    Publication Date: 2024-04-01
    Description: Ce numéro de « Culture Prospective » est une anthologie de plusieurs textes d’Augustin Girard, fondateur du DEPS et observateur avisé de l’économie et la sociologie de la culture en France. Ces onze textes, qui parcourent la seconde moitié du XXème siècle de 1965 à 1997, permettent de découvrir le parcours et les idées d’Augustin Girard mais également de suivre l’évolution de l’activité prospective dans le secteur culturel.
    Keywords: H1-99 ; public policies ; cultural foresight ; thema EDItEUR::N History and Archaeology::NH History
    Language: French
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  • 3
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    Collège de France
    Publication Date: 2022-02-01
    Description: La théorie de Darwin aussi bien que sa réception scientifique, littéraire et politique en France continuent d’être matière à débat. Les controverses qu’elle a suscitées à partir de la première traduction française de L’Origine des espèces en 1862 n’ont pas été le seul fait des naturalistes, des géologues ou des paléontologues. De nombreux autres savants se sont préoccupés de l’impact du darwinisme sur leur discipline, notamment en philologie, dans les mathématiques, la linguistique, la psychologie comparée, l’histoire ou la philosophie. Les auteurs des textes réunis dans Darwin au Collège de France montrent que le Collège de France constitue un point de référence idéal pour étudier les idées de Darwin et leur réception ainsi que la manière dont elles ont pu jouer sur la formation des disciplines du milieu du xixe siècle jusqu’à aujourd’hui. Parmi les défenseurs ou les adversaires français du darwinisme, on compte en effet plusieurs de ses professeurs, à commencer par Pierre Flourens, dont l’Examen du livre de M. Darwin (1864) a été l’un des premiers comptes rendus hostiles de L’Origine des espèces. D’autres figurent encore dans la liste : Ernest Renan, Edgar Quinet, Théodule Ribot, Jean-Charles Lévêque, Étienne-Jules Marey, Jean-François Nourrisson, Michel Bréal, Gabriel Tarde, Henri Bergson, Étienne Gilson. À cette liste s’ajoutent les professeurs de biologie, de médecine, de paléontologie, de neurosciences, ou d’économie politique. Le colloque, dont les contributions sur quelques-uns des savants mentionnés ci-dessus sont réunies dans le deuxième volume de la collection « Passage des disciplines », a été organisé par Alain Prochiantz et Antoine Compagnon dans le cadre du projet « Passage des disciplines : Histoire globale du Collège de France, xixe siècle - xxe siècle », qui s’intéresse à l’évolution des matières enseignées aussi bien que celles qui ont n’y ont pas été admises et qui forment un « Collège virtuel », depuis la fin du xviiie siècle jusqu’aux années 1960. Il est dirigé par Antoine Compagnon, avec la collaboration de Céline Surprenant et le soutien financier de PSL (2016-2019), et de la Fondation Hugot.
    Keywords: P ; D1-2009 ; PN1-6790 ; B1-5802 ; H1-99 ; Q1-390 ; literary criticism ; biology ; psychology ; history of sciences ; social sciences ; literary history ; higher education ; life sciences ; history of ideas ; philosophy ; research
    Language: French
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-20
    Description: Anthropogenic greenhouse gas (GHG) emissions are dramatically influencing the environment, and research is strongly committed to proposing alternatives, mainly based on renewable energy sources. Low GHG electricity production from renewables is well established but issues of grid balancing are limiting their application. Energy storage is a key topic for the further deployment of renewable energy production. Besides batteries and other types of electrical storage, electrofuels and bioderived fuels may offer suitable alternatives in some specific scenarios. This Special Issue includes contributions on the energy conversion technologies and use, energy storage, technologies integration, e-fuels, and pilot and large-scale applications.
    Keywords: Q1-390 ; QC1-999 ; n/a ; PV ; GHG savings ; lithium-ion battery (LIB) ; probability prediction ; decarbonization ; supercapacitor (SC) ; least squares support vector machine ; EV fleet forecasts ; alternative maritime power (AMP) ; Markov chain ; feasibility study ; D funding ; hybrid power system ; numerical analysis ; ship structure ; optimal sizing ; cellulosic ethanol ; electric vehicles EV ; biofuel ; green ship ; R&amp ; bulk carrier ; molten carbonate fuel cell system ; sparse Gaussian process regression ; power-to-gas ; combination method ; charging infrastructure ; jet fuel ; flow characteristics ; hybrid refinery ; LNG-fueled ship ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: English
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  • 5
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 6
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    Presses universitaires de Paris Nanterre
    Publication Date: 2024-04-01
    Description: Si c’est « malgré tout » qu’il faut défendre la sociologie, c’est malgré ce qu’elle est devenue. Bien loin de ses grandes espérances initiales et des splendeurs que nous ont léguées les Durkheim, Weber, Simmel, Mead, Elias, Mauss, etc. Ce que l’on appelle sociologie s’est peu à peu recroquevillé jusqu’à apparaître comme la « science (ou la pseudo science) des restes », la science de ce dont ne parlent ni les philosophes, ni les économistes, ni les historiens, ni les anthropologues, ni les théoriciens de la littérature, etc. Éclatée en de multiples chapelles théoriques ou idéologiques, privée de colonne vertébrale paradigmatique et institutionnelle, elle ne croit plus pouvoir trouver son unité que dans une référence de plus en plus incantatoire au « terrain » et à l’empirisme, et dans ses querelles infinies sur ce qui fait la bonne méthode ou le bon terrain. La sociologie classique, celle qu’il nous faut faire revivre et actualiser, se présentait tout autrement. Elle revendiquait hautement une approche empirique de la réalité et le souci d’établir des faits, elle aussi, mais elle n’imaginait pas que ce puisse être accompli hors-théorie et sans enjeux normatifs, c’est-à- dire éthiques et politiques... Dit autrement, elle se vivait comme le lieu et le moment généraliste de la science sociale générale. C’est cette sociologie là, autrement dit la science sociale générale, qui nous fait désormais défaut et qu’on appelle ici à renaître de ses cendres.
    Keywords: H1-99 ; philosophie politique ; économie ; capitalisme ; utilitarisme ; approche empirique ; scientificité ; sociologie ; thema EDItEUR::N History and Archaeology::NH History
    Language: French
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  • 7
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    Département des études, de la prospective et des statistiques
    Publication Date: 2023-12-20
    Description: En 2011, une association sur cinq a une activité culturelle. Sur ces 267 000 associations culturelles, 35 100 emploient au moins un salarié, l’activité de toutes les autres reposant exclusivement sur la participation bénévole. Il y a 169 000 salariés employés par des associations culturelles, soit 9,4 % de l’emploi salarié associatif. Comme pour les entreprises, les salariés des associations culturelles sont plus fréquemment en contrat court et ont un niveau de formation plus élevé que les salariés des autres secteurs. On compte en moyenne cinq salariés par association culturelle employeuse, deux fois moins que la moyenne. Les associations s’appuient également sur des bénévoles, qui donnent donc de leur temps sans être rémunérés. Les associations culturelles emploient de manière bénévole l’équivalent de 189 000 emplois à temps plein. Le nombre de bénévoles présents dans une association culturelle est d’environ 18. Chaque bénévole travaille en moyenne 63 heures par an dans une association sans salariés, et 86 heures par an dans une association employeuse de salariés. En 2011, le budget cumulé de l’ensemble des associations culturelles est estimé à 8,3 milliards d’euros. En termes monétaires, les associations culturelles pèsent à peu près autant qu’en termes d’emplois au sein de l’économie associative : 9,7 %. Une association culturelle dispose d’un budget moyen de 31 000 euros, deux fois moins que la moyenne d’un budget associatif, du fait de leur taille plus réduite. Les associations culturelles sont moins dépendantes des financements publics (40 %) que la moyenne (49 %). En particulier, elles ont moins accès aux commandes publiques et se financent plutôt par le biais de subventions. Les communes sont, plus que dans les autres secteurs associatifs, à l’origine d’une grande part des subventions, notamment pour les associations qui n’emploient aucun salarié. La moitié des associations culturelles réalise de façon principale ou secondaire une activité d’organisation ou d’accueil de spectacle vivant. Elles ont en moyenne moins de salariés que celles des autres activités culturelles, des budgets plus réduits et ont davantage recours au bénévolat.
    Keywords: H1-99 ; HF5001-6182 ; voluntary work ; cultural associations ; cultural employment ; INSEE (National Institute of statistics and economic studies) ; bic Book Industry Communication::H Humanities
    Language: French
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  • 8
    Publication Date: 2024-04-01
    Description: Dans le sport, l'innovation s'impose de façon non équivoque, au moins en comparaison avec d'autres domaines de la vie sociale. La maîtrise de l'innovation - qu'elle soit ou non technique - et l'obligation de maintenir la recherche de solutions nouvelles sont bien des facteurs d'accès indispensables à la réussite sportive. Des chercheurs en sociologie, histoire économique, management et gestion des entreprises, sciences du sport et communication, ont confronté leurs travaux sur l'évolution de sports aussi divers que l'aviron à ses débuts, le rugby amateur ou professionnel, le football, la voile de compétition, le surf et les sports de glisse en Aquitaine, avec un grand crochet par la Martinique pour les compétitions de yoles martiniquaises… Ils examinent les conditions d'émergence et les multiples configurations que peut prendre l'innovation. Ils dégagent la morphologie des processus d'innovation également étudiés sous l'angle des politiques publiques territoriales et au sein d'associations sportives ou de clubs omnisports marqués depuis peu par des phénomènes de professionnalisation.
    Keywords: H1-99 ; association sportive ; politique publique ; club omnisport ; professionnalisation ; nouvelle technologie ; innovation sportive ; sport ; réussite ; thema EDItEUR::N History and Archaeology::NH History
    Language: French
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  • 9
    Publication Date: 2024-04-01
    Description: Arua como lugar estratégico para a observação da vida urbana no que esta tem de mais peculiar é o tema central deste livro. A proposta é simples e exploratoria: procurar diferentes aproximações a esta realidade complexa a partir do olhar da antropologia, da história, da sociología e da arquitectura, em contextos geográficos e temporais distintos. A rua surge como problema a identificar e como lugar privilegiado para a troca e circulação de saberes disciplinares. Enquanto imagem e símbolo de um modo de vida urbano, lugar onde ocorrem as sociabilidades mais “típicas” da cidade, a rua condensa e viabiliza todo um imaginário feito de discursos, memórias e emoções, que atravessam e elaboram simbolicamente a cidade naquilo que ela tem de mais original. Espaço, tempo e sociabilidade são apenas tres tópicos que ajudam a ler as contribuições da presente colectânea, cujos autores partilham urna preocupação fundamental: apreender a rua à escala de quem a vive, de perto e em situação... Na Paris popular oitocentista, nos actuais campos de refugiados ou na Lisboa dos séculos xix e xx, vamos ao encontro dos lugares da rua.
    Keywords: H1-99 ; city ; urban space ; urban anthropology ; urban history ; socialization ; urban life ; thema EDItEUR::N History and Archaeology::NH History
    Language: Portuguese
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  • 10
    Publication Date: 2023-12-20
    Description: Durante séculos, diversos conhecimentos elaborados e mantidos por grupos sociais considerados à margem da sociedade receberam a classificação de conhecimento popular e conhecimento vulgar, o que demarcou o distanciamento entre esses saberes e o mundo das ciências. Este livro destaca, sob a perspectiva da etnobiologia, o potencial dos saberes tradicionais na construção de ações sustentáveis, refletindo sobre possíveis benefícios para a sociedade. Os autores oferecem análises e informações sobre a contribuição do conhecimento tradicional para a conservação da biodiversidade, para a segurança alimentar e para a saúde, por meio da utilização das plantas medicinais e de outras práticas nativas. O leitor vai perceber que, em muitos momentos, a imposição do mercado ou de pressões políticas não acarretou necessariamente uma melhoria real na alimentação ou na saúde da maior parte da população, como no exemplo dos problemas decorrentes de uma nutrição baseada em alimentos industrializados.
    Keywords: Q1-390 ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: Portuguese
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