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  • Frontiers Media SA  (2,471)
  • KIT Scientific Publishing  (2,057)
  • American Meteorological Society
  • MDPI Publishing
  • Periodicals Archive Online (PAO)
  • 2020-2024  (4,576)
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  • 1
    Publication Date: 2023-12-20
    Description: Auf dem Hintergrund von Organisation und Marke beschäftigt sich der Beitrag mit den Anforderungen an eine moderneFührung aus der Perspektive der unternehmerischen Praxis.
    Keywords: HF5001-6182 ; Dialogische Führung ; Marke ; Führung ; Subsidiaritätsprinzip ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJC Business strategy
    Language: German
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  • 2
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: social-decision making ; animal behavior ; behavioral ecology ; animal collective behavior ; animal SDM ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 3
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    KIT Scientific Publishing
    Publication Date: 2023-12-20
    Description: The reuse of process models is a promising technique to reduce modelling effort. Yet, finding similar models in large model collections is not feasible manually. A search functionality for relevant models, which can be used as a template, is therefore helpful. This work describes multiple techniques for finding similar process models and acitvities in process model repositories.
    Keywords: HF5001-6182 ; Ähnlichkeitsbasierte Suche ; Similarity-based Search ; Process Model Matching ; Geschäftsprozess ; AnfragespracheBusiness Process ; Query Language ; Prozessmodell-Matching ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJC Business strategy
    Language: German
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  • 4
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    KIT Scientific Publishing
    Publication Date: 2024-04-08
    Description: Der vorliegende Band gibt die Beiträge der Ringvorlesung "Verantwortung für die Zukunft. Technik - Ökonomie - Ethik" aus dem Sommersemester 2008 wieder. Behandelt werden neben Fragen der Verantwortung in der Technik, umweltökonomische und umweltethische sowie unternehmensethische Themen. Ergänzend finden sich Überlegungen zur Technikfolgenabschätzung, zu Technik und Kommunikation, zu ethischen und ästhetischen Aspekten bei der Entwicklung von Technik und zur Ethik als Schlüsselqualifikation.
    Keywords: Ethik ; Technik ; Ökonomie ; Schlüsselqualifikation ; bic Book Industry Communication::H Humanities::HP Philosophy::HPQ Ethics & moral philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy
    Language: German
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  • 5
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 6
    Publication Date: 2024-04-09
    Description: Radio communications in the range of 60 GHz enable multi-Gigabit/s network access in indoor environments. Due to the propagation characteristics of such signals only very short range radio transmission is feasible. In order to distribute these signals across large distances, analog transmission over optical fiber is considered. In this work, mode-locked laser diodes serve as optoelectronic oscillators for the generation of such signals. Their system-relevant properties are studied in detail.
    Keywords: T1-995 ; millimeter wave communications ; mode-locked lasers ; wireless personal area networks ; radio-over-fiber ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: English
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  • 7
    Publication Date: 2023-12-21
    Description: This document presents the development and optoelectronic analysis of a flexible electrode system. The focus is the application of all functional layers out of solution to enable a cost effective processing with large area print and coating techniques. Moreover, the mechanical stability of the electrode system and the complete solar cell is investigated by tensile tests.
    Keywords: T1-995 ; organische Halbleiter ; printed electronics ; flexible electronics ; druckbare Elektronik ; Photovoltaik ; flexible Elektronik photovoltaic ; organic semiconductor ; solar cell ; Solarzelle ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 8
    Publication Date: 2023-12-20
    Description: This work is about random measures stationary with respect to a possibly non-transitive group action. It contains chapters on Palm Theory, the Mass-Transport Principle and Ergodic Theory for such random measures. The thesis ends with discussions of several new models in Stochastic Geometry (Cox Delauney mosaics, isometry stationary random partitions on Riemannian manifolds). These make crucial use of the previously developed techniques and objects.
    Keywords: QA1-939 ; mass-transport principle ; Random measure ; ergodic theory ; Stochastic Geometry ; Palm theory ; bic Book Industry Communication::P Mathematics & science
    Language: English
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  • 9
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: omics ; epigenetics ; pharmacogenetics ; CYP ; risk prediction ; microbiota ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 10
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 11
    Publication Date: 2023-12-21
    Description: In automotive lighting technology there have been taken place intense research efforts in the field of adaptive lighting systems to provide a flexible luminance intensity distribution optimally adapted to the situational prevailing traffic and atmospheric situation in the last recent years.This paper describes the development and comparative evaluation of an image-based control system for a marking light approach designed for motor vehicles.
    Keywords: T1-995 ; Bildverarbeitung ; Probandenstudie ; Lichtbasiertes Fahrerassistenzsystem ; Erkennbarkeitsentfernung ; Dynamische Zustandsschätzung ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 12
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: oligodendrocyte ; Schwann cell ; oligodendrocyte precursor cell ; myelin ; myelin repair ; axon physiology ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 13
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
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  • 14
    Publication Date: 2024-04-11
    Description: The design of approaches for future market-based energy network operation faces the technical challenge of needing to coordinate a vast number of network participants spatially and temporally, in order to balance energy supply and demand, while achieving secure network operation. To meet this challenge, the research field of transactive control emerged. Within this work a new transactive control approach for coupled electric power and district heating networks is presented.
    Keywords: Transactive Control; Wärmenetze; Stromnetze; Sektorenkopplung; Energiemärkte; District Heating Networks; Electric Power Networks; Energy Markets ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THR Electrical engineering
    Language: English
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  • 15
    Publication Date: 2023-12-21
    Description: The electrical energy on electrified bicycles offers new functional possibilities such as an active safety system to assist the rider during the braking process. This work shows the technical feasibility of such a system by presenting a rideable prototype. The so-called braking dynamics assistance system prevents the cyclist from both front wheel lockup and rollover (along the vehicle’s transverse axis).
    Keywords: T1-995 ; Elektrofahrrad ; safety system ; Fahrdynamik ; Electric bicycle ; vehicle dynamics ; model-based design ; Verkehrssicherheit ; road safety ; Modellbasierte Entwicklung ; Sicherheitssystem ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 16
    Publication Date: 2024-04-09
    Description: Im Rahmen dieser Arbeit wurde eine Plattform zur individuellen Ansteuerung einer Vielzahl thermisch aktivierter Mikroventile und aktoren, auf Grundlage eines Phasenüberganges, zum Einsatz in der Mikrofluidik entwickelt. Ventile dienen dazu den Fluidstrom in komplexen mikrofluidischen Systemen, aus Einsatzgebieten wie der Biologie, Chemie oder Biotechnologie, zu manipulieren. Mit steigender Komplexität der Mikrosysteme steigt auch die Anzahl der benötigten, individuell steuerbaren Mikroventile.
    Keywords: T1-995 ; thermisch ; Mikrofluidik ; Mikroventile ; Phasenübergang ; Mikroaktoren ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: German
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  • 17
    Publication Date: 2024-04-05
    Description: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Keywords: RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 18
    Publication Date: 2024-04-04
    Description: Evolution of the horse has been an often-cited primary example of evolution, as well as one of the classic and important stories in paleontology for over a century and a half, due to their rich fossil record across 5 continents: North America, South America, Europe, Asia and Africa. The recent horse has served a profound role in human ancestry, including agriculture, commerce, sport, transport, warfare, and in prehistory, for the subsistence of humans. Many studies have examined the evolution of the Equidae and chronicled the striking changes in skulls, dentition, limbs, and body size which have long been perceived to be a response to environmental shifts through time. Most comprehensive studies heretofore have: (1) focused on the “Great Transformation”- changes that occurred in the early Miocene, (2) involved tracking long-term diversity or paleoecological trends on a single continent or within a geographical locality, or (3) concentrated on the 3-toed hipparions. The Plio–Pleistocene evolutionary stage of horse evolution is punctuated by the great climatic fluctuations of the Quaternary beginning 2.6 Ma which influenced Equus evolution, biogeographic dispersion and adaptation on a nearly global scale. The evolutionary biology of Equus evolution across its entire range remains relatively poorly understood and often highly controversial. Some of this lack of understanding is due to assumptions that have arisen because of the relatively derived craniodental and postcranial anatomy of Equus and its close relatives which has seemed to imply that that these forms occupied relatively homogenous and narrow dietary and locomotor niches - notions that have not been adequately addressed and rigorously tested. Other challenges have revolved around teasing apart environmentally-driven adaptation versus phylogenetically defined morphological change. Geochronologic age control of localities, geographic provinces and continents has improved, but in no way is absolute and can be reexamined in our proposed volume. Temporal resolution for paleodietary, paleohabitat and paleoecological interpretations are also challenging for understanding the evolution of Equus. Our proposed volume attempts to assemble a group of experts who will address multiple dimensions of Equus’ evolution in time and space.
    Keywords: Ecomorphology ; Equus ; Paleoecology ; Taxonomy ; Biogeography ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere
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  • 19
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
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  • 20
    Publication Date: 2024-04-05
    Description: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Keywords: RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 21
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
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  • 22
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Keywords: RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 23
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
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  • 24
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    KIT Scientific Publishing
    Publication Date: 2023-12-21
    Description: Within the scope of this work a generic approach to the control of multiple-drive electric vehicles is evolved. An analysis of the overall system with respect to the exploitable degrees of freedom for wheel torque control reveals that several possible solutions for distributing wheel torque exist in certain driving situations. This characteristic of over-actuated systems is exploited in order to pursue further subordinate objectives from from a control perspective.
    Keywords: T1-995 ; mehrmotoriger Antriebsstrangvehicle dynamics control ; efficiency ; energieoptimal ; Elektrofahrzeug ; torque allocation ; Fahrdynamik ; over-actuated ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 25
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Exercise Science ; Performance ; Physiology ; Japan ; Olympics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 26
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: organohalide respiration ; Microbial reductive dehalogenation ; Dehalococcoides ; electron transport chain ; reductive dehalogenase ; Community composition and function ; bioremediation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 27
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    KIT Scientific Publishing
    Publication Date: 2024-04-09
    Description: In this work, the realisation of an adaptive driving beam is examined that is based on the motion prediction of the ego vehicle and other traffic participants. Furthermore, light functions are developed and analysed regarding their effectiveness that project situation adaptive recommendations for action in front of the vehicle regarding a turn or lane change intention of the driver.
    Keywords: T1-995 ; Trajektorienprädiktion ; maneuver detection ; trajectory prediction ; predictive light functions ; Lichtbasierte Assistenzsysteme ; Prädiktive Lichtfunktionen ; Manöverdetektion ; light-based assistance systems ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: German
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  • 28
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: artificial reefs ; offshore oil and gas platforms ; coastal infrastructure ; aquaculture facilities ; anthropogenic influences ; ecological restoration ; marine conservation ; rigs-to-reef ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBK Hydrology and the hydrosphere::RBKC Oceanography (seas and oceans)
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  • 29
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 30
    Publication Date: 2024-03-29
    Description: In the year 2013, ‘selfie’ was named word of the year by Oxford Dictionaries in recognition of dramatic changes in frequency, prominence, and register of the term. This drastic increase in selfie-taking was spurred by two factors. The first was the advent of smartphones equipped with front cameras and preview screens that made it easy to compose a photographic self-portrait by a process of deliberately exploring one’s image, choosing a pose, and finally taking the picture. The second key change contributing to the rise of the selfie age was the increasing availability of internet connections. It is estimated that about 50% of the world population has access to the internet today (2018; https://www.internetworldstats.com). At the end of the past century, this percentage was a mere 1%. The growth of the internet infrastructure simultaneously spurred the development of social network applications such as Facebook, Twitter, Snapchat, and Instagram, providing accessible media for sharing photographs including photographic self-portraits. However, despite their tremendous reach and popularity, selfies have so far received relatively little attention by the scientific community, especially within psychology. Thus, we proposed a Frontiers in Psychology Research Topic to expand empirical and theoretical work on the massively popular, yet scientifically unexplored, phenomenon of the selfie. The articles published in this eBook offer a multifaceted insight into current scholarly work on this topic.
    Keywords: BF1-990 ; Q1-390 ; group selfies ; self-esteem ; Human Computer Interaction (HCI) ; self-presentation ; selfie ; viewing perspective ; perception bias ; smartphones ; social media ; internet ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 31
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    KIT Scientific Publishing
    Publication Date: 2023-12-21
    Description: This book examines the Vehicle-Routing-Problem with split-deliveries and alternative delivery periods (SDVRPA). It is solved with a Branch-and-Price-Algorithm. When alternative delivery periods and split-deliveries are employed, freight forwarders get a wider scope for planning and can therefore plan more efficient routes. Even with few alternative delivery periods, which allow vehicles to be used more efficiently, substantial savings can be achieved.
    Keywords: T1-995 ; Column-Generation ; SDVRPAVehicle-Routing-Problem ; Alternative Periods ; SDVRPA ; Tourenplanung ; Teillieferungen ; Branch-Price-and-Cut ; Alternative Perioden ; Split-Deliveries ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 32
    Publication Date: 2023-12-21
    Description: New methods to generate and analyze motions of humanoid robots are presented and applied to a demonstrator. Reflexes of humans and neural central pattern generators (CPGs) were used as archetype. With leaky Integrate-and-Fire neurons a generic reflex template was designed and put to work for several specialized reflexes. The designed CPGs were used to analyze robotik motion as well as for generation of locomotion patterns on a biped demonstrator.
    Keywords: T1-995 ; Reflexe ; Humanoider Roboter ; Zentrale MustergeneratorenHumanoid Robot ; CentralPatternGenerator ; Reflexes ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 33
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    KIT Scientific Publishing
    Publication Date: 2024-04-11
    Description: Sandstone is the most common kind of natural stone used for historic buildings in Central Europe. During the past century a dramatic increase in different types of damage to historic buildings, monuments and sculptures made from natural stone has been observed. The present work deals with theoretical aspects of strength loss, fracture processes and degradation during the decay processes.
    Keywords: TA1-2040 ; Ermüdung ; weathering model ; Lebensdauer ; finite element methods ; durability ; Verwitterungsmodell ; FEMsandstone ; Sandstein ; fatigue behaviour ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: German
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  • 34
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.
    Keywords: QP1-981 ; Q1-390 ; Vitamin D ; Immune System ; Genomics ; vitamin D receptor ; Physiology ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 35
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    KIT Scientific Publishing
    Publication Date: 2023-12-21
    Description: Die vorliegende Arbeit beschäftigt sich mit der Phasengleichgewichts- und Stofftransportcharakteristik vernetzter Polymere, wie sie in Controlled-Release-Anwendungen, der Brennstoffzellen- und Separationstechnologie oder der Sensor-Aktor-Technik zum Einsatz kommen. Dabei werden insbesondere auch Strategien zur quantitativen Bestimmung der relevanten Gleichgewichts- und Transportparameter vorgestellt, welche auf der Kopplung einer spektroskopischen Messmethode und Simulationsrechnungen basieren.
    Keywords: T1-995 ; Polymermembran ; Stofftransport ; Polyvinylalkohol ; Raman-Spektroskopie ; Phasengleichgewicht ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 36
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: resting-state fMRI ; fMRI denoising ; vascular modulation ; head motion ; arousal ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 37
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    KIT Scientific Publishing
    Publication Date: 2023-12-21
    Description: In this work, a novel measurement system for the analysis of the gyrotron RF output spectrum was developed. It enables unprecedented time dependent measurements within a large bandwidth, dynamic range and unambiguous RF indication in the entire D-Band (110-170 GHz). Special attention was given to the investigation of parasitic RF oscillations, and the analysis of the interplay of thermal cavity expansion and ionization-based space charge neutralization at the start of long RF pulses.
    Keywords: T1-995 ; spectrum analysis ; Mikrowellenmesstechnik ; millimeter waves ; Gyrotron ; Spektralanalyse ; Millimeterwellen ; microwave measurement techniques ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 38
    Publication Date: 2023-12-20
    Description: A predictive tracking approach and a novel method for visual motion compensation are introduced, which accurately reconstruct and compensate the deformation of the elastic object, even in the case of complete measurement information loss. The core of the methods involves a probabilistic physical model of the object, from which all other mathematical models are systematically derived. Due to flexible adaptation of the models, the balance between their complexity and their accuracy is achieved.
    Keywords: QA75.5-76.95 ; stochastic estimation ; physics-based modeling ; robotics ; distributed parameter systems ; beating heart surgery ; video processing ; probabilistic models ; bic Book Industry Communication::U Computing & information technology::UY Computer science
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  • 39
    Publication Date: 2024-04-09
    Description: Das Wiederherstellen der Akkommodationsfähigkeit des Auges bei Presbyopie oder nach Kataraktoperationen stellt derzeit eine der größten Herausforderungen der Augenheilkunde dar. Das Künstliche Akkommodationssystem ermöglicht die dauerhafte Wiederherstellung der Akkommodationsfähigkeit. In der vorliegenden Arbeit wird ein neues Konzept für die bedarfsgerechte Energieversorgung des Künstlichen Akkommodationssystems erstellt.
    Keywords: T1-995 ; Akkommodationssystem bedarfsgerecht Energieversorgung ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: German
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  • 40
    Publication Date: 2023-12-21
    Description: Die Steuerung von künstlichen Gliedmaßen durch Muskel- bzw. Nervensignale oder von virtuellen Tastaturen durch Hirnsignale erfordert eine Schnittstelle, die die menschlichen Wünsche erfasst, interpretiert und dem angeschlossenen System verfügbar macht. Bestehende Systeme zeichnen sich durch eine einfache Bedienbarkeit aus, verfügen jedoch nur über eine eingeschränkte Funktionalität und müssen zudem manuell entworfen werden.In dieser Arbeit wird ein neues Verfahren zum automatischen Entwurf von MMIs vorgestellt und so die Funktionalität bestehender Systeme erweitert.
    Keywords: T1-995 ; Mensch-Maschine-Schnittstelle ; Diskriminanzfunktion ; Mensch-Maschine-Kommunikation ; Echtzeitverarbeitung ; Entwurfsautomation ; Steuerung ; Lernende Steuerung ; Klassifikation ; Muskelkontraktion ; Systementwurf ; Gehirn-Computer-Schnittstelle ; Echtheit / Merkmal ; Diskriminanzanalyse ; Elektromyographie ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 41
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    Frontiers Media SA
    Publication Date: 2022-01-31
    Description: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Keywords: RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
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  • 42
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
    Keywords: RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Astrocytes ; DREADD ; Cortex ; plasticity ; Gq ; Behavior ; glia ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 43
    Publication Date: 2024-04-05
    Description: Ein wesentlicher Aspekt dieser Arbeit ist die Suche nach besseren Donorkomponenten für die, mit Hilfe der Kokondensationstechnik dargestellten, Germaniummonohalogenidlösungen.Des Weiteren befaßt sich die Arbeit mit der Folgechemie von metalloiden Germaniumclustern sowohl in Lösung, als auch in der Gasphase.
    Keywords: QD1-999 ; metalloid ; Kokondensation ; Cluster ; Germanium ; Folgechemie ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: German
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  • 44
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Thy-1 ; CD90 ; Signal Transduction ; cell-cell interaction ; Cell-matrix interaction ; Scaffold ; Nanodomains ; integrin ; Mechanotransduction ; Cancer ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 45
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: export ; secretion ; pathogens ; toxins ; macromolecular machineries ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases
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  • 46
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
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  • 47
    Publication Date: 2023-12-20
    Description: Der Autor beleuchtet den längst überfälligen Paradigmenwechsel in der Welt von Arbeit und Bildung: Aporien der Führung - Aspekte von Autonomie - Bedingungsloses Grundeinkommen - Salutogenese - Dialogische Kultur liefern ermutigende und spannende Ansätze zum neuen Verständnis eines zentralen Lebensfeldes.
    Keywords: HF5001-6182 ; Arbeit ; Dialogische Führung ; Führung ; Bildung ; Grundeinkommen ; Dialogische Kultur ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJC Business strategy
    Language: German
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  • 48
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Heart Rate ; Heart rate variability ; Autonomic Nervous System ; infants ; Children ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 49
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: NMDAR = N-methyl-d-aspartate receptor ; Enzymes - metabolism ; enzyme drug target ; d-serine ; L-serine ; thema EDItEUR::P Mathematics and Science::PD Science: general issues
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  • 50
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    Frontiers Media SA
    Publication Date: 2024-03-30
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: biobank ; samples ; data ; biobank network ; BBMRI
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  • 51
    Publication Date: 2023-07-05
    Description: Ein noch offenes Problem der optischen 3D-Modellerfassung ist die Notwendigkeit einer zeitintensiven, manuell gestützten Montage mehrerer Ansichten bzw. Tiefenbilder zu einem geschlossenen 3D-Oberflächenmodell. Könnte dieser Vorgang der sog. 3D-Registrierung in den Scanprozess verlagert werden, so könnte das bisher erfasste Gesamtergebnis dem Anwender visualisiert werden und dieser hätte die Möglichkeit, interaktiv auf noch nicht erfasste Bereiche einzugehen. In der vorliegenden Arbeit wird hierzu ein neuer Ansatz entwickelt und vorgestellt.
    Keywords: QA75.5-76.95 ; Oberfläche ; Profil 〈Oberfläche〉 ; Oberflächenprüfung ; Optische Messung ; Triangulierung ; Optische Messtechnik ; Messtechnik ; Kalibrieren 〈Messtechnik〉
    Language: German
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  • 52
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial ; activity ; extracellular enzyme ; marine ; freshwater ; Metabolic potential ; function ; metabolic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 53
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    KIT Scientific Publishing
    Publication Date: 2024-04-11
    Description: The increasing use of automated laser welding processes causes high demands on process monitoring. This work demonstrates methods that use a camera mounted on the focussing optics to perform pre-, in-, and post-process monitoring of welding processes. The implementation uses machine learning methods. All algorithms consider the integration into industrial processes. These challenges include a small database, limited industrial manufacturing inference hardware, and user acceptance.
    Keywords: CNN; stacked dilated U-Net; semantic segmentation; hairpin technology; laser welding; quality assurance; machine learning; Qualitätssicherung; semantische Segmentierung; Hairpin Technologie; Laserschweißen; Maschinelles Lernen; Künstliche Intelligenz ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THR Electrical engineering
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  • 54
    Publication Date: 2024-04-09
    Description: The aim of this work was to identify the patterns that can induce heating around implanted cardiac pacemakers during MRI and to develop strategies to counteract them. Two approaches were taken: computer simulations of the occurring electromagnetic field distributions and in-vitro experiments using phantoms in real MRI devices, both for conventional bore-hole and new open MRI systems. Using the open MRI, the observed heating could be reduced significantly.
    Keywords: T1-995 ; pacemaker ; MRI ; numerical field calculation ; biomedical engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
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  • 55
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: precise genome editing ; CRISPR ; HDR efficiency ; biallelic HDR targeting ; off-target effect ; animal model ; base editing ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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  • 56
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    KIT Scientific Publishing
    Publication Date: 2024-04-04
    Description: The annual report of the Institute for Nuclear and Energy Technologies of KIT summarizes its research activities and provides some highlights of each working group, like thermal-hydraulic analyses for fusion reactors, accident analyses for light water reactors, and research on innovative energy technologies: liquid metal technologies for energy conversion, hydrogen technologies and geothermal power plants. The institute has been engaged in education and training in energy technologies.
    Keywords: Fusion ; Kernenergie ; Flüssigmetall-Technologien ; Wasserstofftechnologien ; geothermische Energie ; Jahresbericht ; Nuclear energy ; liquid metal technologies ; hydrogen technologies ; geothermal energies ; annual report ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 57
    Publication Date: 2024-04-11
    Description: Several experimental campaigns are conducted to find feasible fiber reinforcements for buildings under earthquake conditions. Therefore tensile tests for the description of the bonding behavior of the fibers, shear tests on three-stone small specimen, small static cyclic shear wall tests, bending tests of wall segments, large format dynamically loaded wall plates and five building experiments were performed under realistic time history acceleration. At the end a calculation method is proposed.
    Keywords: TA1-2040 ; masonry ; Erdbeben ; Verstärkungen ; fiber reinforced concrete ; Bemessung ; Faserverbundwerkstoffe ; earthquake ; Mauerwerk ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: German
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  • 58
    Publication Date: 2024-04-05
    Description: In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.
    Keywords: RC321-571 ; Q1-390 ; non-invasive brain stimulation NIBS ; TMS-EEG ; Transcranial magnetic stimulation TMS ; transcranial electric stimulation tES ; Coregistration ; Near-infrared spectroscopy NIRS ; Functional magnetic resonance imaging fMRI ; transcranial direct current stimulation tDCS ; transcranial alternating current stimulation tACS ; transcranial random noise stimulation tRNS ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 59
    Publication Date: 2024-04-11
    Description: Ultrasound Tomography is an emerging technology for medical imaging that is quickly approaching its clinical utility. Research groups around the globe are engaged in research spanning from theory to practical applications. The International Workshop on Medical Ultrasound Tomography 2019 brought together scientists to exchange their knowledge and discuss new ideas and results in order to boost the research in Ultrasound Tomography.
    Keywords: Ultraschall Tomographie ; Medizinische Bildgebung ; Ultrasound Tomography ; Medical Imaging ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THR Electrical engineering
    Language: English
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  • 60
    Publication Date: 2024-04-05
    Description: Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship between them; in addition they typically fail to reach towards location of the single object, which they can perceive. The deficit of the allocation of spatial attention in Balint’s syndrome has been linked to a problem in feature binding which results in illusory conjunctions. Patients with Balint’s syndrome also show deficits in global processing i.e. when integration of multiple local elements into global compound shapes is required. Consequently, Balint’s syndrome provides a unique opportunity to study the nature and neuroanatomy of human visuospatial processing, in particular multi-level object representation, spatial awareness and the distribution of visual attention. The studies collected here cover both the anatomical and the cognitive mechanisms of the different symptoms associated with the syndrome. Furthermore, the dissociations between the components of Bálints’ syndrome, in particular simultanagnosia and optic ataxia, can also co-occur with visual neglect and extinction and the different combinations of reported lesions raises a question about the status of the syndrome and whether it should be merely treated as a historical compilation of symptoms which may or may not coexist cohesively. This interesting argument is raised here.
    Keywords: RC321-571 ; Q1-390 ; posterior cortical atrophy ; Balints syndrome ; optic ataxia ; Posterior parietal cortex ; simultanagnosia ; ocular apraxia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 61
    Publication Date: 2023-12-21
    Description: In this work fiber reinforced polymers were characterized. The composites were manufactured with optimized resin transfer molding (RTM) production strategies to make the standard RTM process more efficient. To determine where the potential of the new production techniques is the quasi static mechanical properties were measured and also calculated with an analytical modulation. On this database the different processes were compared to each other.
    Keywords: T1-995 ; Werkstoffprüfung ; RTM-Fertigungsverfahren ; process comparison ; Polymer ; RTM ; Verbundwerkstoff ; materials characterization ; RTM manufacturing process ; Glasfaser ; aserverbundwerkstoffe ; Prozessvergleich ; fiber reinforced polymers ; Materialcharakterisierung ; Analytische Modellierung ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 62
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    KIT Scientific Publishing
    Publication Date: 2024-04-09
    Description: In this work, the realization limits of an impulse-based Ultra-Wideband (UWB) localization system for indoor applications have been thoroughly investigated and verified by measurements. The analysis spans from the position calculation algorithms, through hardware realization and modeling, up to the localization experiments conducted in realistic scenarios. The main focus was put on identification and characterization of limiting factors as well as developing methods to overcome them.
    Keywords: T1-995 ; localization ; UWB ; transceiver ; positioning ; ultra-wideband ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
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  • 63
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    KIT Scientific Publishing
    Publication Date: 2024-03-24
    Description: The essays collected in this volume explore some of the themes that have been at the centre of recent debates within Wittgensteinian scholarship. In opposition to what we are tentatively inclined to think, the articles of this volume invite us to understand that our need to grasp the essence of ethical and religious thought and language will not be achieved by metaphysical theories expounded from such a point of view, but by focusing on our everyday forms of expression.
    Keywords: philosophy ; wittgenstein ; philosophie ; Moral ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFA Philosophy of language ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHR Western philosophy from c 1800
    Language: German
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  • 64
    Publication Date: 2024-04-11
    Description: In der vorliegenden Arbeit wurde der Einfluss der Zylindergeometrie (zylindrisch; rippenförmig) auf die Mischcharakteristik eines kontinuierlich durchströmten Taylor-Vortex Reaktors untersucht. Hierfür wurde die Makro- und Mikromischung mittels Spurstoffversuchen, Messung des Rührenergieeintrages und einer chemischen Testreaktion bestimmt.
    Keywords: TP155-156 ; Spurstoffversuche ; Mikromischung ; alkalische Verseifung Ethylacetat ; Taylor-Vortex Reaktor ; Makromischung ; spezifischer Rührenergieeintrag ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
    Language: German
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  • 65
    Publication Date: 2024-04-05
    Description: The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
    Keywords: RC321-571 ; Q1-390 ; Glaucoma ; Visceral Pain ; Calcium ; membrane guanylate cyclase ; ANF-RGC ; Gene Therapy ; Cyclic GMP ; synaptic plasticity ; trafficking ; ROS-GC ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 66
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial communities ; Pollutants ; Environmental risk assessment ; Bioindication ; Biodegradation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 67
    Publication Date: 2024-04-09
    Description: Teleskopierbare, spielbehaftete Hubgerüste von Gabelstaplern werden während eines Arbeitszyklus oftmals zu Schwingungen angeregt. Die charakteristischen Schwingungseigenschaften, bedingt durch das usammenwirken von Spiel, auskragender Last und Schwerkraft, werden experimentell untersucht und durch ein 5-Massen-Modell sehr gut abgebildet.Sowohl mit aktiven als auch mit passiven Maßnahmen lassen sich die Schwingungen schnell und deutlich reduzieren.
    Keywords: T1-995 ; Maschinenelement ; Spiel ; Schwingungsverhalten ; Gabelstapler ; Flurförderer ; Hubgerüst ; Schwingungsdämpfer ; Schwingungstilger ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: German
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  • 68
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    KIT Scientific Publishing
    Publication Date: 2023-12-21
    Description: Verbrennungsprozesse sind meist mit der Emission von Schadstoffen verbunden, weshalb sie möglichst schadstoffarm und energieeffizient geführt werden müssen.Bei den bislang dominierenden primären Brennstoffen sind aufgrund der gleichbleibenden Brennstoffeigenschaften langfristig optimierte Technologien und feste Regelungen einsetzbar. Zunehmend werden jedoch sekundäre Brennstoffe wie Prozessabgase oder Biomasse genutzt. Sie haben stark veränderliche chemisch-physikalische Eigenschaften und bewirken so einen veränderlichen Verbrennungsablauf der schwierig beherrschbar ist. Eine optimale Verbrennung lässt sich dann nur durch eine an den Verbrennungszustand und die Brennstoffe adaptierte modellbasierte Prozessregelung erreichen, die noch nicht Stand der Technik ist.Die Arbeit widmet sich im ersten Schwerpunkt dem modellbasierten Reglungsentwurf. Die theoretische Modellierung und der modellbasierte Entwurf adaptiver Regelungen für die Temperatur und die Sauerstoffkonzentration im Abgas wird am Beispiel einer halbtechnischen Brennkammer für veränderliche Brenngase analysiert. Berücksichtigt wird dabei das für Verbrennungen typische vorhaltbehaftete Regelstreckenverhalten.Der zweite Schwerpunkt bildet die online Messung und die rechnerba-sierte Auswertung von Zustandsgrößen am Beispiel der infrarotbasierten Temperaturmessung bei einem Feststoffbrennbett. Es werden neue Auswerteverfahren entwickelt, die sich u.a. auch bei der Regelung industrieller Verbrennungen bewährt haben.
    Keywords: T1-995 ; Modellierung ; Verbrennungsanalyse ; Regelungstechnik ; Technikumsanlage ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 69
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Alzheimer's disease ; Neurodegeneration ; Peptides ; cognitive ; model ; Parkinson's disease ; database ; transgenic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 70
    Publication Date: 2023-12-21
    Description: The gas phase direct hydroxylation of benzene into phenol with hydrogen and oxygen, as initially described by Niwa in 2002, was realized in a newly developed double-membrane reactor. In the concept described by Niwa, a dense Pd membrane is used for the (safe) dosage of dissociated hydrogen species into the tubular reaction zone, where it reacts with gas phase oxygen to form surface species capable of directly converting benzene into phenol in a single-step process.
    Keywords: T1-995 ; Pd-Membran ; Katalyse ; Phenol ; Benzol ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 71
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    KIT Scientific Publishing
    Publication Date: 2023-12-21
    Description: High temperature superconducting (HTS) bulks and stacks of coated conductors can be magnetized to become trapped-field magnets that provide much stronger magnetic fields than those reachable with conventional permanent magnets. This work investigates the flux dynamics during the magnetization of HTS trapped-field magnets and proposes possible strategies to improve the trapped field produced by the pulsed field magnetization method that is promising for practical applications.
    Keywords: T1-995 ; trapped-field magnet ; Hochtemperatur-Supraleiter ; pulsed field magnetization ; High temperature superconductor ; Supraleiter mit eingeschlossenem Magnetfeld ; gepulste Feldmagnetisierung ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 72
    facet.materialart.
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Sport ; performance ; physiology ; kinesiology ; biomechanics ; health ; exercise ; physical activity ; athletes ; training ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::S Sports and Active outdoor recreation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKW Sports injuries and medicine
    Language: English
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  • 73
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    KIT Scientific Publishing | KIT Scientific Publishing
    Publication Date: 2024-04-11
    Description: Elastocaloric cooling is an emerging solid-state cooling technology with the potential to provide environmentally friendly, efficient cooling. The elastocaloric effect in superelastic shape memory alloy films is used to develop advanced cooling devices for small-scale applications. Cascaded and parallelized devices are developed to increase device temperature span and cooling capacity. The concepts are proven experimentally, a maximum temperature span of 27° C is achieved in a cascaded device.
    Keywords: Elastokalorik ; Festkörperkühlung ; Kaskadierte Kühleinheit ; Superelastische Formgedächtnislegierung ; Aktive Miniatur Kühlung ; Elastocaloric Cooling ; Solid-State Cooling ; Superelastic Shape Memory Alloy ; Cascaded Cooling Device ; Small Scale Cooling ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials
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  • 74
    Publication Date: 2024-04-05
    Description: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.
    Keywords: RC321-571 ; Q1-390 ; Nervous System ; Ion Channels ; Interactome ; cellular signaling ; Protein complexes ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 75
    Publication Date: 2024-04-11
    Description: Experiments to characterize the effects of moisture content and temperature on the mechanical properties of concrete were conducted. Based on these experiments, a new overall material model capable of predicting the mechanical behaviour of concrete subject to elevated temperatures up to 100 °C was developed. The material model estimates the time, temperature and moisture dependency of the compressive and tensile strength, creep and shrinkage of concrete.
    Keywords: TA1-2040 ; concrete ; Temperatur ; Beton ; Schwinden ; Temperature ; strength ; Kriechen ; creep ; Festigkeit ; shrinkage ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 76
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Brainstem monoamine neurons ; locus coeruleus ; emotion ; pain ; morphometry ; amphetamine derivatives ; sleep ; gaze ; trigeminal nerve ; microglia. ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 77
    Publication Date: 2024-04-05
    Description: Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.
    Keywords: QH426-470 ; Q1-390 ; Regional heritability ; prostate cancer ; infectious diseases ; MCMC ; combining studies screening ; conditional-logistic linkage ; Informatics ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
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  • 78
    Publication Date: 2024-04-11
    Description: Polymer solar cells can be produced by a continuous low cost coating and drying process. This work details a specialized experimental set-up to enable large scale roll to roll processing. Material properties such as surface energy, surface tension, and viscosity are presented and modelled. The impact of coating method, as well as process parameters (e.g. coating speed, shear rate, solvent composition) on process stability and film properties, is discussed.
    Keywords: TP155-156 ; Viscosity ; ViskositätPolymer solar cell ; Polymersolarzelle ; Organic Electronic ; Beschichtung ; Organische Elektronik ; Prozess ; Process ; Coating ; Trocknung ; Drying ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
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  • 79
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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  • 80
    Publication Date: 2022-01-31
    Description: This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.
    Keywords: Q1-390 ; small-Hsp ; Hsp60/CCT/BBS ; Indirect/Secondary Chaperonopathies ; Genetic Chaperonopathies ; Hsp40/DnaJ ; chaperonotherapy
    Language: English
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  • 81
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    KIT Scientific Publishing
    Publication Date: 2024-04-02
    Description: Wer Nordsee sagt, meint Langeoog, heißt es griffig auf einem Werbeprospekt für 1931/32. Aber wofür steht eigentlich Langeoog? Welche sozialen Konstruktionen haben sich zwischen den 1930er und 1980er Jahren mit der Insel verbunden? Wer waren ihre Träger und was waren deren Vorstellungen von Nordseeurlaub? Was wandelt sich daran vor, während und nach dem Nationalsozialismus? Was von seinen Prägungen ist bis weit in die 1960er Jahre noch deutlich erkennbar und warum ist das so? Diesen und anderen Fragen gehen die folgenden Essays zu ausgewählten Aspekten der Sozial und Mentalitätsgeschichte Langeoogs im 20. Jahrhundert nach.
    Keywords: Nordseeinsel Langeoog ; Nordseeurlaub ; 1930er bis 1980er Jahre ; Nationalsozialismus ; Nachkriegszeit ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: German
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  • 82
    Publication Date: 2024-04-05
    Description: Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent respiratory virus infection. To solve the issues, it is essential to clarify and delineate both aspects of the virus and host defense systems including acute/chronic inflammation and airway tissue remodeling. To deeply review and discuss pathophysiology and epidemiology of virus-induced asthma, this topics includes new findings of the host immunity, pathology, epidemiology, and virology of asthma/chronic obstructive pulmonary disease (COPD). We believe that these works are well summarized and informative to glimpse the field of virus- associated asthma and COPD, and may help understanding the basic and clinical aspects of the diseases.
    Keywords: QR1-502 ; QK1-989 ; Q1-390 ; virus-induced asthma ; Pathology ; respiratory virus ; human immunity ; Epidemiology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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  • 83
    Publication Date: 2023-12-21
    Description: Comprehension of the beating of the human heart is important for cardiac research and will improve many clinical applications. Simulations based on models describing cardiac electro-mechanics can acquire insights into this behavior. This work focuses on the mathematical reconstruction of electrophysiology, excitation conduction, and tension development in the human heart on the cellular and the tissue level. The tissue models represent accurate anatomical shapes of the atria and the ventricles and incorporate electrophysiological heterogeneity and anisotropic conduction. The simulations comprehend the physiological behavior of the ventricles and of the atrium including the sinoatrial node as well as pathological cases like ventricular and atrial fibrillation and genetic defects in ionic channels.
    Keywords: T1-995 ; Heterogenität ; Gewebe ; Kardiologie ; Computersimulation ; Ionenkanal ; Aktionspotenzial ; Erregung ; Elektrophysiologie ; Muskelfaser ; Kraft ; Tachykardie ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 84
    Publication Date: 2024-04-11
    Description: The subject of this PhD-thesis is the transferability of Facility Management (FM) by using the example of hospitals in Germany and Iran. The intention is to determine the status and significance of facility management in the project countries, to analyse similarities, semblances and differences in order to develop a system transferability model.
    Keywords: TA1-2040 ; health system ; facility management ; system transferability ; hospital ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 85
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    KIT Scientific Publishing
    Publication Date: 2023-12-21
    Description: At the 37th Prandtl memorial lecture on Regions of Viccous Flow, H.Oertel 1994 developed for the first time the stability theory of local perturbations in boundary layers and wake flows, as well as their practical application in the flow control of vehicle flows and the boundary layer of civil aircraft wings.This work presents how the stability theory concept of absolute instability has advanced and proven in practice in the last 15 years in terms of the efficient flow control.
    Keywords: T1-995 ; Flow Control ; Fluid Mechanics ; Stability Theory ; Wake Flow ; Bundary Layer Transition ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: English
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  • 86
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
    Language: English
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  • 87
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    KIT Scientific Publishing
    Publication Date: 2024-03-28
    Description: ‚Vertrauen‘ spielt in fast allen Bereichen menschlichen Lebens eine wichtige Rolle. Von ‚Vertrauen‘ wird gesprochen in Bezug auf Personen, Unternehmen, Verbände, Vereine, Institutionen, Technik, Wirtschaft, Wissenschaft ganz allgemein, Medien usw. Es gibt das Urvertrauen, die vertrauensvolle Zusammenarbeit im Betrieb, Ranglisten des Vertrauens in Berufe bzw. Berufsgruppen, die Vertrauensfrage bzw. den Misstrauensantrag im Parlament, den Vertrauensschaden im Recht und eine Asymmetrie im Aufbau und dem Verlust bzw. bei der Zerstörung des Vertrauens. Das Vertrauen der Konsumenten wird durch Kunstschinken und Analogkäse getäuscht bzw. auf eine harte Probe gestellt. Wir sollen in neue bzw. alte ‚Techniken‘ vertrauen – z.B. in die verschiedenen Arten der Gentechnik, in das Internet-Banking, in das E-Business, in Navigationssysteme –, aber können wir das auch?
    Keywords: Vertrauen ; Wissenschaft ; Technik ; Ökonomie ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTZ General studies and General knowledge
    Language: German
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  • 88
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    Unknown
    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Transfer cells are anatomically specialized cells optimized to support high levels of nutrient transport in plants. These cells trans-differentiate from existing cell types by developing extensive and localized wall ingrowth labyrinths to amplify plasma membrane surface area which in turn supports high densities of membrane transporters. Unsurprisingly, therefore, transfer cells are found at key anatomical sites for nutrient acquisition, distribution and exchange. Transfer cells are involved in delivery of nutrients between generations and in the development of reproductive organs and also facilitate the exchange of nutrients that characterize symbiotic associations. Transfer cells occur across all taxonomic groups in higher plants and also in algae and fungi. Deposition of wall ingrowth-like structures are also seen in “syncytia” and “giant cells” which function as feeding sites for cyst and root-knot nematodes, respectively, following their infection of roots. Consequently, the formation of highly localized wall ingrowth structures in diverse cell types appears to be an ancient anatomical adaption to facilitate enhanced rates of apoplasmic transport of nutrients in plants. In some systems a role for transfer cells in the formation of an anti-pathogen protective barrier at these symplastic discontinuities has been inferred. Remarkably, the extent of cell wall ingrowth development at a particular site can show high plasticity, suggesting that transfer cell differentiation might be a dynamic process adapted to the transport requirements of each physiological condition. Recent studies exploiting different experimental systems to investigate transfer cell biology have identified signaling pathways inducing transfer cell development and genes/gene networks that define transfer cell identity and/or are involved in building the wall ingrowth labyrinths themselves. Further studies have defined the structure and composition of wall ingrowths in different systems, leading in many instances to the conclusion that this process may involve previously uncharacterized mechanisms for localized wall deposition in plants. Since transfer cells play important roles in plant development and productivity, the latter being relevant to crop yield, especially so in major agricultural species such as wheat, barley, soybean and maize, understanding the molecular and cellular events leading to wall ingrowth deposition holds exciting promise to develop new strategies to improve plant performance, a key imperative in addressing global food security. This Research Topic presents a timely and comprehensive treatise on transfer cell biology to help define critical questions for future research and thereby generating a deeper understanding of these fascinating and important cells in plant biology.
    Keywords: QK1-989 ; Q1-390 ; Wall ingrowth ; Arabidopsis thaliana ; synctial cells ; Zea mays ; transfer cells ; endosperm transfer cells ; Giant Cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: English
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  • 89
    Publication Date: 2024-04-05
    Description: Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress.
    Keywords: RC321-571 ; Q1-390 ; stress ; Obesity ; Dopamine ; Ghrelin ; Leptin ; Seasonal regulation ; feeding ; HPA axis ; Hypothalamus ; circadian rhythms ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 90
    Publication Date: 2024-04-11
    Description: Kalium-Natrium-Niobat (KNN) ist eine bleifreie ferroelektrische Keramik. Seine Herstellung ist aufgrund des hygroskopischen Verhaltens von Alkalikarbonat und Verdampfung bei hohen Temperaturen eine Herausforderung. Während des Herstellungsverfahrens wird die erwünschte Stöchiometrie schwanken. Undotierten und kupferdotierten KNN mit Alkali- oder Niobüberschüssen wurden hergestellt. Ihre Strukturbildung, Sinterverhalten, Mikrostrukturbildung und ihre elektrischen Eigenschaften werden untersucht.
    Keywords: T1-995 ; ferroelektrisch ; Stöchiometrie ; piezoelektrisch ; Keramik ; bleifrei ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering::TDCQ Ceramic and glass technology
    Language: German
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  • 91
    Publication Date: 2024-04-05
    Description: euromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
    Keywords: RC321-571 ; Q1-390 ; Informed Consent ; Deep Brain Stimulation ; Depression ; Neurosurgery ; Movement Disorders ; Neuromodulation ; Enhancement ; Neuroethics ; Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 92
    Publication Date: 2023-12-21
    Description: Several in-depth studies have verified the positive impact of lean techniques on performance indicators in production environments. Studies performed on warehouse environments have partially confirmed this. This thesis helped to close the gap between the disparities in the level of evidence mentioned above. A study was conducted that included 16 warehouses in an observation group and 56 warehouses in a control group. These significant results help close the gap in the evidence.
    Keywords: T1-995 ; Lean Management ; Lean Production ; schlanke Produktionssysteme ; Lager ; LogistikLean Management ; KPI ; Logistikzentren ; Lean Warehousing ; Logistics ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: English
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  • 93
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    Unknown
    KIT Scientific Publishing
    Publication Date: 2023-07-06
    Description: Für die Opfer zahlreicher Kriege alleine im 20. Jahrhundert ist die Thematik "Konflikt - Trauma - Neubeginn" von schrecklicher Kontinuität. Angesichts der Terrorangriffe auf das World Trade Center und das Pentagon hat das Thema eine weitere Bedeutung und Brisanz gewonnen. An vielen Orten der Welt schwelen Konflikte, die erst dann wahrgenommen werden, wenn es zu spät ist. Gesellschaftlicher Zusammenhalt steht allzu oft auf gefährlich dünnem Eis, das jederzeit einzubrechen droht. Der vorliegende Band widmet sich unter dieser Perspektive terroristischen Bedrohungen, Kriegen und Völkermord in ihrer historischen Dimension und aktuellen Problematik. Ein breites Spektrum an Expertinnen und Experten aus der Politik, Geschichtswissenschaft, Philosophie und institutionellen Praxis, aber auch Zeitzeugen und Opfer von Gewalttaten kommen in diesem Heft der Problemkreise der Angewandten Kulturwissenschaft zu Wort.
    Keywords: Trauma ; Konfliktbewältigung ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPW Political activism::JPWL Terrorism, armed struggle
    Language: German
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  • 94
    Publication Date: 2024-03-29
    Description: The integration of multisensory information is an essential mechanism in perception and in controlling actions. Research in multisensory integration is concerned with how the information from the different sensory modalities, such as the senses of vision, hearing, smell, taste, touch, and proprioception, are integrated to a coherent representation of objects. Multisensory integration is central for action control. For instance, when you grasp for a rubber duck, you can see its size and hear the sound it produces. Moreover, identical physical properties of an object can be provided by different senses. You can both see and feel the size of the rubber duck. Even when you grasp for the rubber duck with a tool (e.g. with tongs), the information from the hand, from the effect points of the tool and from the eyes are integrated in a manner to act successfully. Over the recent decade a surge of interest in multisensory integration and action control has been witnessed, especially in connection with the idea that multiple sensory sources are integrated in an optimized way. For this perspective to mature, it will be helpful to delve deeper into the information processing mechanisms and their neural correlates, asking about the range and constraints of this mechanisms, about its localization and involved networks.
    Keywords: BF1-990 ; Q1-390 ; recalibration ; haptic ; Human Information Processing ; Vision ; Perception ; reference frame ; Acoustics ; Tool Use ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 95
    Publication Date: 2023-12-21
    Description: Innerhalb des zweijährigen Verbundprojektes KLASTER (Klassifikationssysteme automatisiert erstellen) wurde aufbauend auf den Ergebnissen des Vorgängerprojektes PAK (Produkte automatisch klassifizieren) ein Konzept erarbeitet und validiert, das eine Automatisierung des Klassifizierungsprozesses erlaubt. Während innerhalb von PAK die automatische Einordnung von Objekten in eine existierende Klassenstruktur behandelt wurde, beschäftigt sich KLASTER mit der automatischen Erstellung eines unternehmensspezifischen Klassensystems.Der vorliegende Abschlussbericht beschreibt neben dem Konzept ausführlich Anwendungsbeispiele bei den beteiligten Projektpartnern.
    Keywords: T1-995 ; Klassifikation ; Datenverwaltung ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 96
    Publication Date: 2024-04-05
    Description: Volume I, entitled “Augmentation of Brain Functions: Brain-Machine Interfaces”, is a collection of articles on neuroprosthetic technologies that utilize brain-machine interfaces (BMIs). BMIs strive to augment the brain by linking neural activity, recorded invasively or noninvasively, to external devices, such as arm prostheses, exoskeletons that enable bipedal walking, means of communication and technologies that augment attention. In addition to many practical applications, BMIs provide useful research tools for basic science. Several articles cover challenges and controversies in this rapidly developing field, such as ways to improve information transfer rate. BMIs can be applied to the awake state of the brain and to the sleep state, as well. BMIs can augment action planning and decision making. Importantly, BMI operations evoke brain plasticity, which can have long-lasting effects. Advanced neural decoding algorithms that utilize optimal feedback controllers are key to the BMI performance. BMI approach can be combined with the other augmentation methods; such systems are called hybrid BMIs. Overall, it appears that BMI will lead to many powerful and practical brain-augmenting technologies in the future.
    Keywords: RC321-571 ; Q1-390 ; microcircuits ; Brain machine interface (BMI) ; nootropics ; tDCStranscranial direct current stimulation ; neural networks ; neuroprosthesis ; TMS ; implants ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 97
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    KIT Scientific Publishing
    Publication Date: 2023-12-21
    Description: This work presents investigates the feasibility of the ""directly steered wheels (DSW)"" under operating condition of tramcars. After analyzing the wheel/rail geometric contact between track and DSW, a mathematical model has been developed to describe the lateral dynamics. Based on this model, a robust guidance controller is designed according to the µ-synthesis. The results of simulations show that the DSW with the designed controller can improve the running performance of tramcars significantly.
    Keywords: T1-995 ; aktive Spurführung ; active guidance ; directly steered wheels ; Straßenbahn&#956 ; -Synthesis ; µ-synthesis ; wheel/rail geometric contact ; Rad-Schiene-Kontaktkinematik ; aktiv gelenktes Radpaar ; tramcar ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Language: German
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  • 98
    facet.materialart.
    Unknown
    KIT Scientific Publishing
    Publication Date: 2024-04-05
    Description: August Ludwig Hülsen (1765-1809) was a contributor to the emergence of German idealism. Notwithstanding, his name and works are up to this day almost entirely unknown to most scholars in the field. This monograph discusses the historical importance of Hülsen's Prüfung der von der Akademie der Wissenschaften zu Berlin aufgestellten Preisfrage: Was hat die Metaphysik seit Leibniz und Wolf für Progressen gemacht? (1796), his only book, for the emergence of German idealism, especially the thought of Reinhold and Fichte during the 1790's. The usual way of focusing on the Wissenschaftslehre, and hence, on the emergence of German idealism, is as a “response” of Fichte to the skeptical objections of Schulze-Aenesidemus to Reinhold's early Elementarphilosophie. This “response”, as Fichte himself recognized in 1798, was far from complete. Hülsen, a Fichtean thinker, restructured and regrounded those aspects of Reinhold's system that Fichte left intact: in particular, Reinhold's almost forgotten approach to the rational history of philosophy. In 1797, Hülsen's achievement prompted Fichte's recommendation of Hülsen's book in Annalen des philosophischen Tons as an introduction to his Wissenschaftslehre. This indicates that Fichte recognized Hülsen as a partner in the development of his incomplete system. Accordingly, the historical importance of Hülsen's book is that it completed Fichte's attempt to overcome Reinhold's standpoint and contributed to the emergence of German idealism.
    Keywords: German Idealism ; August Ludwig Hülsen ; Johann Gottlieb Fichte ; Karl Leonhard Reinhold ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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  • 99
    Publication Date: 2024-04-09
    Description: This work has arisen out of the strong demand for a superior power-added efficiency (PAE) of AlGaN/GaN high electron mobility transistor (HEMT) high-power amplifiers (HPAs) that are part of any advanced wireless multifunctional RF-system with limited prime energy. Different concepts and approaches on device and design level for PAE improvements are analyzed, e.g. structural and layout changes of the GaN transistor and advanced circuit design techniques for PAE improvements of GaN HEMT HPAs.
    Keywords: T1-995 ; MMIC design ; power amplifier ; AlGaN/GaN HEMT ; X-band ; power-added efficiency ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: English
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  • 100
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
    Language: English
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