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  • COVID-19  (379)
  • MDPI - Multidisciplinary Digital Publishing Institute  (378)
  • American Chemical Society
  • Copernicus
  • Nature Publishing Group (NPG)
  • Taylor & Francis
  • 2020-2024  (379)
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  • 2020-2024  (379)
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  • 101
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: Toll-like receptors (TLRs) represent a powerful system for the recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens and damage-associated molecular patterns (DAMPs) released from dying cells. Typical PAMPs include bacterial cell wall components, viral pathogens, or pathogenic nucleic acids, including viral RNA and DNA. Activation of TLRs leads to the production of proinflammatory cytokines and type I interferons which are important for the induction of the host immune response against bacterial and viral infections. However, dysregulation and overstimulation can be detrimental, leading to hyper-inflammation, sepsis, and loss of tissue integrity. The involvement of TLRs in inflammation and bacterial infection has been recognized for a long time. There is an increasing number of reports demonstrating the involvement of TLR activation in a variety of viral infections, associated with protective immunity, but also immune hyper activation and even viral replication. Recent data show the involvement of TLR activation in various acute respiratory viral infections, including SARS-CoV-2 and indicate an essential role in COVID-19 pathology. It aimed to gather newest data and hypotheses regarding molecular and cellular mechanisms of TLR triggering and activation and their downstream signaling pathways by viral infections, and their correlation to immunology and pathophysiology of the associated diseases, to facilitate translational research resulting in new targets for the treatment of viral infectious diseases including COVID-19.
    Keywords: hepatitis C virus ; infection ; innate immunity ; Toll-like receptor ; cytokines ; Omicron ; spike protein ; SARS-CoV-2 ; COVID-19 ; cytokine storm ; NF-kappaB ; Toll-like receptor (TLR) ; monoclonal antibody TLR4 ; compression force ; MAPKs ; AKT ; human PDL ; sterile inflammation ; TLR ; immune system ; inflammation ; antiviral ; polymorphism ; sepsis ; septic shock ; TLR7 ; TLR8 ; 2′-O-ribose-methylation ; RNase T2 ; immune activation ; CD14 ; LPS ; hop ; TLR4 ; oligonucleotide ; sncRNA ; endocytosis ; broad-spectrum ; antiviral agent ; nucleolin ; virus entry ; immunoregulation ; RNA therapeutics ; TLR7 (Toll-like receptor 7) ; MUC1 (Mucin 1) ; aluminum adjuvant ; tumor vaccine ; immunotherapy ; toll-like receptor-2 (TLR2) ; advanced glycation end products (AGEs) ; aquaporin-3 (AQP3) ; histone deacetylase inhibitor ; diabetes ; keratinocytes ; skin ; n/a ; TLR4–RAGE crosstalk ; glucose ; lipopolysaccharide (LPS) ; inflammatory ; alveolar macrophages ; bic Book Industry Communication::M Medicine
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  • 102
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: The purpose of the Special Issue was to collect the results of research and experience on the consequences of the COVID-19 pandemic for the energy sector and the energy market, broadly understood, that were visible after a year. In particular, the impact of COVID-19 on the energy sector in the EU, including Poland, and the US was examined. The topics concerned various issues, e.g., the situation of energy companies, including those listed on the stock exchange, mining companies, and those dealing with renewable energy. The topics related to the development of electromobility, managerial competences, energy expenditure of local government units, sustainable development of energy, and energy poverty during a pandemic were also discussed.
    Keywords: energy manager ; competences ; labor market ; energy industry ; COVID-19 ; decarbonizing transport ; energy efficiency ; electrify transport ; zero-emissions vehicles ; sustainable transport ; electric car charging points ; novel coronavirus pandemic ; alternative energy ; stock market sectors ; stock market companies ; energy ; energy company ; efficiency ; financial analysis ; pandemic ; environmental protection ; environmental problems ; greenhouse gas ; particulate matter (PM) ; renewable energy ; corruption ; electromobility ; companies in the Transport-Shipping-Logistics Sector ; pandemic-COVID-19 ; development ; self-government units ; energy consumption ; monitoring ; energy consumption effectiveness ; sustainable energy development ; households ; OPEC ; crude price ; volatility ; storage crisis ; futures ; shale ; electric vehicles market and policy ; electric vehicles ; purchase intention ; e-mobility ; consumers preferences ; consumer decision making ; social values ; delay discounting ; cultural factors ; economic factors ; machine learning methods ; sustainability ; energy poverty ; economic uncertainty ; energy policy ; policy measures ; reducing energy intensity ; ranking of countries’ energy intensity ; multi-criteria analysis ; sectors of the economy ; economic effects of the pandemic ; social effects of the pandemic ; countries of Western Europe ; countries of Central and Eastern Europe ; mining sector ; initiatives and adaptation measures ; economic situation ; COVID-19 pandemic ; fossil fuel energy ; carbon dioxide emissions ; nonlinear autoregressive distributed lag model ; frequency domain causality test ; Markow switching regression ; photovoltaics ; pandemics ; changes in energetic balance due to COVID-19 ; renewable sources of energy during pandemics ; United States ; energy sector ; fossil fuel ; emissions ; expenditures ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PH Physics
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  • 103
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-02
    Keywords: online learning ; higher education ; engagement ; interactive strategies ; learner engagement ; blended learning ; institutional support ; support for engagement ; COVID-19 ; digital learning environments ; teaching anxiety ; online teaching ; student engagement ; coping strategies ; distance learning ; visualizing web application ; progress in learning ; perceived usefulness ; companies ; accounting ; student retention ; student success ; learning analytics ; STEM ; Chinese as a foreign language (CFL) ; intervention program ; cultural study ; Chinese culture ; VooV Meeting ; mathematical modeling ; mathematics education ; differential equations ; engineering education ; Learning Analytics ; Educational Data Mining ; student performance prediction ; clickstream data ; mobile-assisted language learning (MALL) ; English vocabulary learning and teaching ; WeChat ; higher education (HE) ; mainland China ; emotional well-being ; educational innovation ; stress ; education in emergency ; insomnia ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JN Education
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  • 104
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-23
    Description: This reprint covers various aspects of sustainable urbanisation. It includes empirical evidence, theoretical insights, and practical recommendations in order to inform and inspire sustainable urban strategies. The ten original research studies presented in this reprint explore topics such as green buildings, rail transportation, land-use efficiency, energy consumption, innovation management, heritage preservation, digital technologies, and behaviour change. The interdisciplinary and international scope of the issue reflects the complexity and diversity of the challenges and opportunities encountered when striving for urban sustainability. This Special Issue aimed to provide researchers, practitioners, policymakers, and students with a comprehensive and up-to-date perspective on sustainable urban development.
    Keywords: green buildings ; occupant well-being ; healthy buildings ; occupant-orientation ; indoor environment conditions ; residential property ; public transportation ; metro ; rail ; flat ; resource-based city ; green land use efficiency (GLUE) ; carbon emissions ; the Yellow River Basin (YRB) ; multimodal data ; attention mechanisms ; data fusion ; urban planning ; energy consumption ; building energy ; spatial autocorrelation ; multiscale geographically weighted regression (MGWR) ; prefabricated construction ; digital green innovation management ; venture capital ; project partners ; transfer of development rights (TDR) ; land registry ; land management ; preservation of buildings ; historic buildings ; development restriction ; development loss ; floor area ; Turkey ; sustainable urban planning ; digital legislation and policy ; rural digitalization reform ; digital technology ; energy conservation ; extraversion ; green hotel ; past behaviour ; personality traits ; pro-environmental management ; city–county consolidation ; market competition ; earnings management ; urbanization development ; sustainable urban development ; urban resilience ; influencing factors ; Chengdu–Chongqing urban agglomeration ; urban rail transit (URT) ; PPP ; value creation ; grounded theory ; smart home ; secure architecture ; blockchain ; storage efficiency ; IoT ; climate change ; GHG mitigation ; public policy ; enabler networks ; net-zero roadmap ; developing countries ; social network analysis ; COVID-19 ; COVID-19 response policy ; operational restrictions on facilities ; Night-Time Economy (NTE) ; Night-Time Economic Vitality (NTEV) ; credit-card sales ; PLS-SEM (partial least square structural equation modeling) ; formative measurement model ; superblocks urbanism ; gulf urbanization ; street connectivity and efficiency ; walkability ; sustainable urban development policy and practice ; urban vulnerabilities ; vulnerable communities ; multidisciplinary approach ; disciplinary boundaries ; design workshops ; research by design ; Design for Vulnerables ; Krebs cycle design ; generative urban design ; evidence-based design decision-making ; activity-based model ; transit-oriented development ; amenity accessibility ; green roofs ; sustainable urban planning and design ; urban development ; public perception ; urban policy and governance ; Saudi Arabia ; post-occupancy evaluation ; semantic differential method ; sports parks ; real estate enterprise ; digitalization ; operations management ; barriers ; FTA–DEMATEL–ISM ; sustainability ; heritage redevelopment ; participatory design ; public engagement ; community value ; social value ; Faro Convention ; HUL ; heritage ; cognitive mapping ; urban regeneration ; text mining ; keyword network analysis ; students’ participation ; social network service ; stakeholder ; Korea ; industrial building renovation ; brownfield buildings ; conflicts ; stakeholders ; n/a ; innovation district ; user preferences ; user-centric planning ; decision makers’ perspectives ; urban policy ; Kelvin Grove Urban Village ; Diamantina Knowledge Precinct ; Brisbane Technology Park ; Brisbane ; Australia ; sustainable development ; Central Taiwan Science Park ; green infrastructure ; residents’ opinions ; urban ecosystem ; environmental education ; thema EDItEUR::A The Arts ; thema EDItEUR::A The Arts::AM Architecture
    Language: English
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  • 105
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint, entitled “Process Control and Smart Manufacturing for Industry 4.0”, contains the extended papers from the Series of annual IFSA conferences on Automation, Robotics and Communications for Industry 4.0/5.0 (ARCI) on the following topics: Process Automation, Process Control and Monitoring, Design Principles in Industry 4.0, Smart Manufacturing and Technologies, Smart Factories, Machine Learning and Artificial Intelligence in Manufacturing. The reprint contains 13 chapters written by 54 ARCI conference participants from seven countries: China, Croatia, Denmark, Germany, Italy, Poland and Romania. This reprint will inform readers of cutting-edge developments in the field and provide effective starting points and a road map for further research and development. All chapters follow the same structure: firstly, an introduction to the specific topic under study; secondly, a description of the field, including sensing or/and measuring applications. Each chapter ends with a curated list of references, including books, journals, conference proceedings and websites. “Process Control and Smart Manufacturing for Industry 4.0” is intended for researchers and scientists from academia and industry, as well as for postgraduate students.
    Keywords: steel alloys ; resistance spot welding ; RSW ; electrode wear ; electrode tip-dressing ; process monitoring ; mushrooming ; plateau forming ; quality control ; COVID-19 ; FDM ; 3D printing ; injection molding ; personal protection ; rapid prototyping ; protective face shields ; mechatronics line ; visual servoing system ; wheeled mobile robot ; industrial robotic manipulator ; Industry 4.0 ; NDT ; magnetic particle inspection ; optimization ; condition monitoring ; vibration ; acoustic emission ; drive train ; data fusion ; machine learning ; product morphology ; core data model ; phase rule filter ; phase private data model ; storage system ; forklift AGV ; deep learning ; semantic segmentation ; H-Swish ; community transformation ; community innovation governance ; ternary space ; coupling and coordination analysis ; lean manufacturing ; lean principles ; pull principle ; production control mechanisms ; production processes ; lean implementation ; batch process ; partial least squares ; multi-phase ; multi-mode ; master production scheduling ; make-to-order ; mathematical programming ; agent-based ; overtime ; earliness ; tardiness ; equipment selection decision ; business compass ; energy consumption ; processing time ; beetle antennae search algorithm ; sustainable blank dimension design ; energy-saving ; low-carbon ; grey wolf algorithm ; gas–solid ; cyclone ; separator ; gas dynamics ; erosion ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 106
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The second volume of the Special Issue entitled “Antimicrobial Prescribing and Stewardship” consists of manuscripts, including original research articles, review articles, and opinion papers regarding antimicrobial stewardship-related topics, including disease-based/organism-based antimicrobial stewardship; the influence of antimicrobial utilization changes on antimicrobial resistance; the impact of antimicrobial stewardship on quality performance measures and patient outcomes; novel antimicrobial stewardship education and training approaches or interventions aimed toward the public and/or healthcare workers; behavioral change approaches to antimicrobial stewardship; collaborative practice agreements in antimicrobial stewardship; antimicrobial stewardship in special populations (e.g., pediatrics, geriatrics, emergency medicine, hematology/oncology); tackling AMR through antimicrobial stewardship in low- and middle-income countries; antimicrobial stewardship for animal health; antimicrobial stewardship in alternative settings (e.g., community practice, long-term care, resource-limited settings, small and rural hospitals); antimicrobial use and stewardship in the context of the COVID-19 pandemic; and global collaborations to tackle AMR through antimicrobial stewardship.
    Keywords: antimicrobial stewardship programs ; hospitals ; multi-drug resistance ; antibiotics ; antimicrobial stewardship ; quality of prescription ; prescriptive appropriateness ; surgical prophylaxis ; antibiotic stewardship ; febrile neutropenia ; appropriateness ; pharmacist-driven ; hematology oncologic patient ; hospital care ; primary care ; physicians ; antibiotic ; prescription ; Portugal ; upper respiratory tract infections ; antimicrobial resistance ; parental knowledge ; attitudes ; practices ; child ; Greece ; COVID-19 ; emergency department ; prescribing ; antimicrobial prescribing ; behavior change ; primary healthcare ; general practice ; community pharmacy ; qualitative study ; patient attitudes ; self-care ; questionnaire ; behavioural science ; global-pps ; antimicrobial surveillance ; antimicrobials ; ceftriaxone prescription ; prevalence ; Uganda ; life-long ; suppression ; multi-resistant organisms ; antibiotic prophylaxis ; joint replacement ; prosthetic joint infection ; oral implantology ; dental implants ; hospital physicians ; low-resistance country ; antibiotic prescription ; semi-structured interviews ; antibiotic prescribing quality ; low-risk intra-abdominal infections ; post-operative antibiotic treatment ; antimicrobial drug use ; dairy cattle ; knowledge ; logistic regression models ; machine learning ; survey ; cystitis ; fluoroquinolones ; point prevalence survey ; antibiotic use surveillance ; hospital ; private sector ; global health security ; multisectoral ; stewardship ; surveillance ; collaboration ; antimicrobial use ; food animals ; AMU ; DDD ; biosecurity ; animal welfare ; anthelmintics ; prudent use ; imprudent use ; livestock production systems ; Fiji ; healthcare providers ; infectious diseases ; caregivers ; antibiotic resistance ; rural population ; India ; antimicrobial resistance (AMR) ; antimicrobial stewardship (AMS) ; AMS Game ; board game ; online game ; Commonwealth Partnerships for Antimicrobial Stewardship ; CwPAMS ; gaming ; game-based learning ; gamification ; prescribing app ; anti-infective ; antimicrobial ; behaviour change ; healthcare workers ; national action plans ; pharmacy ; One Health ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 107
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Keywords: website premia ; international firm activities ; Flash Eurobarometer 421 ; innovation networks ; knowledge ; R&D cooperation ; patents ; persistence ; data protection ; cookie consent fatigue ; privacy concerns ; legal remedies ; union wage premium ; collective bargaining ; union membership ; Germany ; online channels sales ; firm performance ; COVID-19 ; Germany 2021 Enterprise Survey Data Set ; educational economics ; signaling theory ; international student mobility ; degree mobility ; high-ability students ; Bologna reforms ; youth entrepreneurship ; entrepreneurship ; spatial context ; demographics ; entrepreneurship policies ; Global Entrepreneurship Monitor (GEM) ; short-time work ; dynamic labour demand ; panel analysis ; high-frequency establishment data ; core-periphery hypothesis ; fixed-term contracts ; job security ; linked employer-employee data ; temporary agency work ; remote sensing ; global public goods ; unsupervised ML ; structural topic modeling ; text as data ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCM Development economics & emerging economies
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  • 108
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This reprint emerges as a beacon guiding researchers, scientists, and medical professionals through uncharted territories. In this volume, we delve deep into the intricate world of immunization, where the fusion of bioinformatics and network medicine reshapes our understanding of vaccines' efficacy, safety, and immunogenicity.
    Keywords: monkeypox ; mpox ; MPXV ; universal vaccine ; multi-epitope mRNA vaccine ; immunoinformatics ; influenza ; H3N2 ; antigenic distance ; hemagglutinin ; attribute network embedding ; herpes simplex virus ; HSV-2 ; vaccine ; costimulation ; genital ; antibodies ; T cells ; MDV ; chickens ; Th17 cells ; IL-17A ; interferon-gamma and adaptive immunity ; adenoviral vector ; cell fusion ; human endogenous retrovirus type W (HERV-W) ; R-peptide ; Syncytin-1 ; HIV ; PLWH ; ART ; vaccination ; immune responses ; CD4 ; COVID-19 ; HPV ; respiratory syncytial virus ; RSV ; mucosal vaccine ; inactivated vaccine ; low-energy electron irradiation ; LEEI ; PC formulation ; PCLS ; binding antibody assay ; immune correlates of protection ; modified treatment policy ; neutralizing antibody assay ; principal stratification ; principal surrogate ; SARS-CoV-2 ; stochastic intervention ; stochastic interventional vaccine efficacy ; peste des petits ruminants ; ewes ; lambs ; passive immunity ; quadrivalent adjuvanted influenza vaccines ; toll-like receptors ; CVID ; azoximer bromide ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
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  • 109
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Arts therapy is a form of psychotherapy that uses artistic media, the creative process, and artwork as its primary forms of communication. The arts therapies cover six areas of specialization: visual arts, music, dance and movement, drama, psychodrama, and bibliotherapy. Several studies and reviews have demonstrated its effectiveness for adult populations (e.g., Regev and Cohen-Yatziv, 2018), as well as for children and adolescents (e.g., Cohen-Yatziv and Regev, 2019). Academic writing and research, which have evolved extensively in recent decades, have underscored the considerable significance of arts therapies especially for children and adolescents.This Special Issue, “Arts Therapies with Children and Adolescents”, is dedicated to presenting research and clinical writing in the field of the Arts Therapies with Children and Adolescents in a variety of settings, including hospitals, the education system, mental health clinics, and others. I hope that this Special Issue will serve as a repository of knowledge for arts therapists and as a fertile terrain for further research in the field. It should also pave the way for more professionals working with children and adolescents to better understand the meaning and uniqueness of the therapeutic work in arts therapies and the dedicated ways in which arts therapists use assessment tools and arts-based interventions to better understand the world of children and adolescents.
    Keywords: creative arts therapy ; online psychotherapy ; COVID-19 ; education system ; remote therapeutic response ; child abuse ; sexual abuse ; physical abuse ; emotional abuse ; self-figure drawing ; dance movement therapy ; remote therapy ; art therapy ; music therapy ; dramatherapy ; children ; schools ; randomised controlled study (RCT) ; mental health ; well-being ; prevention ; intellectual disability ; adolescents ; mother–adolescent relationship ; joint painting procedure ; music ; PICU ; anxiety ; quality improvement ; questionnaires ; parent-child arts therapy ; Autism Spectrum Disorders ; the creative arts ; OS-ID ; open studio ; identity development ; supported autonomy ; social anxiety ; autism spectrum disorders ; change processes ; OAT ; EAT ; at-risk children ; art ; foster care ; school arts therapies ; behavioral problems ; experience of art making ; art materials ; art process ; art products ; drama therapy ; youth ; review ; psychosocial problems ; mechanisms of change ; psychodrama ; PPAT ; self-potency ; EF ; maternal distress ; political violence ; refugee children/adolescents ; process evaluation ; sense of belonging ; affect ; resilience ; arts therapies ; ultra-Orthodox Jews ; intercultural therapy ; parents’ perceptions ; rehabilitation ; medical clowning ; physiotherapy ; role theory ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 110
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint focuses on studies dealing with bio-based materials and its contribution to a circular economy. Research dealing with recycling, waste conversion to bio-based products, the development of bio-based composites, and surface treatments on cellulose fibres have been included in this reprint.
    Keywords: microcrystalline cellulose ; Conocarpus fiber ; morphology ; crystallinity ; thermal stability ; poly(lactic acid) ; poly(butylene succinate) ; scanning electron microscopy ; tensile properties ; biocomposites ; blend ; recycle composites ; biodegradable ; mechanochemical esterification ; long fatty acid chain ; oleic acid ; ionic liquid ; magnetic mortar and pestle ; induced disease resistance ; sodium alginate ; polysaccharides ; plant growth-promoting bacteria ; lignin ; polypropylene ; tobacco lignin ; blends ; characterization ; biopolymers ; bio-based ; plantain ; natural fibers ; agroindustrial waste ; starch biopolymer ; birch bark ; wood coating ; suberin fatty acids ; hydrophobicity ; artificial aging ; geopolymer ; fly ash ; sugarcane bagasse ash ; mechanical properties ; dielectric properties ; bioplastics ; biobased plastics ; plastic degradation ; bioplastic sources ; plastic business case ; bioplastic legislation ; waste plastics ; fillers ; Prosopis juliflora ; thorn powder ; abrasive wear resistance ; chitosan ; antibiotic ; Gram-positive and -negative bacteria ; drug delivery ; heavy metal removal ; COVID-19 ; wound healing ; ASA polymer ; fused deposition modelling ; infill density ; L18 orthogonal array ; 3D printing ; n/a ; sand-fixing materials ; attapulgite ; biological mycelia ; 16S rDNA sequencing technology ; soil feritlity ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PH Physics
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  • 111
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Research and development related to smart, connected, and portable biosensors and bioelectronics have been game changing in the fields of diagnostics and health management. Unlike conventional biosensors, these devices allow rapid, accurate, and on-site detection of biomarkers, which helps to prevent disease spread by the source control. This reprint contains experimental/computational studies and systematic reviews that report advances towards addressing current challenges and the future scope of the field of portable biosensors and bioelectronics.
    Keywords: portable biosensor ; biomarkers in body fluids ; portability ; point-of-care ; biosensor ; ZnO NWs ; piezoelectric effect ; self-powered ; real-time monitoring ; waveguide ; surface plasmon resonance ; graphene ; silicon carbide ; refractive index ; chemical sensor ; autopsy record ; three-dimensional model ; LiDAR sensor ; wearable ; flexible compound sensor ; wrist pulse signal ; the varying trend of pulse wave peak ; best pulse wave positioning ; single-walled carbon nanotubes ; immunoresistive sensor ; resistance ratio ; COVID-19 ; point-of-care diagnosis ; automatic sleep stage classification ; convolutional neural network ; nanomembrane electrode ; multi-taper spectrogram ; photoplethysmography ; remote monitoring ; computational modeling and simulation ; medical device design ; triboelectric nanogenerator ; self-powered device ; adaptivity ; clinical treatment ; self-diagnosis ; wearable paper sensor ; molecular imprinting ; conductive polymer ; lentivirus ; virus sensor ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 112
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-23
    Description: The rapid emergence of COVID-19 presented unprecedented challenges to the education sector. COVID-19 caused the full or partial closing of schools and universities, as well as the cancellation of face-to-face activities in most parts of the world. To conduct business as usual, many higher education providers have taken steps towards digital transformation, moving to online or hybrid learning and teaching delivery approaches. This reprint provides timely research on the impact of COVID-19 on education systems, including the lessons learned. It seeks to unite scholars, educators, policymakers and practitioners to collectively and critically identify, investigate and share the best practices that may lead to rethinking and reframing the way we deliver education in the future.
    Keywords: COVID-19 ; online instruction ; belongingness ; engagement ; STEM education ; study abroad ; international education ; community of inquiry ; CoI ; emergency remote teaching ; ERT ; online learning ; graduate students ; digital divide ; undergraduates ; internet access ; technology access ; Hispanic-Serving Institution ; underserved and vulnerable students ; lecturing ; lecture capture ; higher education ; flipped teaching ; blended learning ; digital learning ; student perspective ; disruptive learning contexts ; transformational learning ; graduate competencies ; postgraduate medical education ; registrars ; face-to-face classes ; academic performance ; history/mission ; internet/virtual learning ; first-year undergraduates ; second-year undergraduates ; general chemistry ; survey ; assessment ; social media ; technology ; professional identity ; academic lecturers ; seniority ; academic rank ; work performance ; occupational security ; digital education ; teaching and learning ; sustainable education ; educational innovation ; ‘New Normal’ transition ; face-to-face education ; online education ; physics ; belonging ; hybrid learning ; laboratory-based teaching ; student engagement ; student experience ; teaching ; higher education academy (HEA) ; learning ; education ; diversity ; group learning ; sustainability ; systematic review ; annotated bibliography ; interior architecture ; blended online learning ; research modules ; curriculum ; post-COVID-19 ; teacher education ; distance learning ; nursing education ; social learning ; peer mentor ; thema EDItEUR::A The Arts ; thema EDItEUR::A The Arts::AF The Arts: art forms::AFC Paintings and painting
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  • 113
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: This Antimicrobial Prescribing and Stewardship Issue (volume 1) consist of manuscripts, including original research, review articles, case series, and opinion papers for topics related to antimicrobial (antibiotic, antifungal) stewardship, including: Disease-based/organism-based antimicrobial stewardship;Diagnostic stewardship;Influence of antimicrobial utilisation changes in antimicrobial resistance;Impact of antimicrobial stewardship on quality performance measures and patient outcomes;Novel antimicrobial stewardship education and training approaches or interventions aimed at the public and/or healthcare workers;Behavioural change approaches to antimicrobial stewardship;Collaborative practice agreements in antimicrobial stewardship;Antimicrobial stewardship in special populations (e.g., paediatrics, geriatrics, emergency medicine, hematology/oncology);Tackling AMR through antimicrobial stewardship in low- and middle-income countries;Antimicrobial stewardship for animal health;Antimicrobial stewardship in alternative settings (e.g., community practice, long-term care, and resource-limited small and rural hospitals);Antimicrobial use and stewardship in the context of the COVID-19 pandemic;Global collaborations to tackle AMR through antimicrobial stewardship.
    Keywords: antimicrobial stewardship ; pharmacy ; sepsis ; wound management ; culture and sensitivity testing ; resistance patterns ; low-and middle-income countries ; Uganda ; antibiotic ; antimicrobial resistance ; veterinary ; animal health ; Africa ; bone infection ; joint infection ; osteomyelitis ; pediatric infectious disease ; septic arthritis ; antibiotics ; microbial resistance ; upper respiratory tract infections ; fosfomycin ; urinary infection ; resistance ; CwPAMS App ; smartphone apps ; antimicrobial prescribing ; low- and middle-income countries ; barriers and enablers ; training ; antibiotics use ; behavior change ; Helicobacter pylori ; therapy ; metronidazole ; clarithromycin ; fluoroquinolones ; amoxicillin ; proton pump inhibitors ; ethical trials ; obesity ; bloodstream infection ; antimicrobials ; prescription ; community health workers ; health practitioners ; infection prevention and control ; multidisciplinary ; one health ; UK ; antimicrobial resistance (AMR) ; antimicrobial stewardship (AMS) ; delayed/back-up prescribing ; developing countries ; LMICs ; Ghana ; knowledge ; attitudes ; medical students ; antimicrobial ; stewardship ; prescribing ; meningitis ; encephalitis ; FilmArray ; multiplex PCR ; rapid diagnostic technology ; children ; adolescents ; outcomes ; antibiotic stewardship program ; complementarity ; prospective audit and feedback ; antibiotic stewardship ; pharyngitis ; acute otitis media ; clinical pathways ; emergency departments ; antibiotic use ; prescribing appropriateness ; follow-up blood cultures ; Gram negative bacteremia ; critically ill patients ; antibiotic therapy ; general practice ; family practice ; health policy ; quality of health care ; public health ; pharmacist ; nurse ; COVID-19 ; antibiotic resistance ; wound care ; burn care ; Nepal ; AMS ; antimicrobial stewardship intervention ; PDSA cycle ; enterococcal ; bacteremia ; epidemiology ; risk factors ; mortality ; urinary tract infections (UTI) ; older adults ; qualitative ; leaflet ; Theoretical Domains Framework ; coronavirus ; SARS-CoV-2 ; anti-infective agents ; candidemia ; hematologic diseases ; complex intervention ; bic Book Industry Communication::M Medicine
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  • 114
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Robotics and intelligent systems are key technologies to promote efficient and innovative applications in the most diverse domains (industry, healthcare, agriculture, construction, mobility, etc.), performing and supporting activities that are not suitable to be performed by humans. Such activities are frequently time-consuming, repetitive tasks with low added value, which are physically demanding and/or dangerous. Nevertheless, robotics and intelligent systems face several scientific and technological challenges related to their integration and interoperability with other systems, safety, flexibility, re-configurability and autonomy. These challenges are especially relevant when robots operate in real unstructured environments and share a workspace with humans and other equipment. This reprint collects research achievements, ideas, and applications regarding advanced intelligent robotic systems, covering diverse technologies and application domains. Generically, the contributions cover optimal path-planning strategies and innovative designs for mobile manipulators, the integration of robotic and intelligent systems, grasping, manipulation, teleoperation, haptics, user experience approaches for collaborative robots, and multi-agent systems.
    Keywords: robot ; manipulator ; robotized workplace ; robotic cell ; optimization ; wear ; motion planning ; trajectory tracking ; mobile manipulator ; joint constraints ; self-collision avoidance ; manipulability ; service robot ; assistant robot ; collaborative robot ; healthcare ; elderly care ; intelligent systems ; COVID-19 ; multi-agent systems ; bigraphs ; design ; verification ; modeling ; non-functional requirements ; robot path planning ; RRT ; midpoint interpolation ; triangular rewiring ; path smoothness ; non-prehensile manipulation ; manipulation planning ; pivoting ; robotics ; mobile manipulation ; large-scale inspection ; wind turbine production ; autonomous navigation ; surface-orthogonal path planning ; intelligent robot ; flexible production ; manipulation ; intelligent control ; User eXperience ; human–robot interaction ; human–robot collaboration ; human-centered design ; augmented reality ; human factors ; omnivehicle ; omnitracks ; Mecanum rollers ; FDM ; simultaneous localization and mapping ; dual lidar inertial odometry ; IMU ; time synchronization ; tight coupling ; impact hammers ; industrial robotics ; haptic teleoperation ; underground mining ; genetic algorithm ; principal component analyses ; standard triangle language ; traveling salesman problem ; trajectory planning ; haptic recognition ; convolutional neural network ; channel attention ; spatial interactive second-order feature ; multiorder feature ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 115
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: With the advancements in the medical and scientific fields, the global community has acquired a comprehensive understanding about brain insults and pathologies. In addition, new findings and discoveries are being made globally every day, which keep our curiosity high and drive a knowledge gain. Any brain insult or pathology is multifactorial, including a cascade of inflammation, necrotic, and apoptotic pathways; can be influenced by genetic or environmental factors; and may lead to chronic neurodegeneration or disabilities. This Special Issue, entitled “Brain Injury and Neurodegeneration: Molecular, Functional, and Translational Approach”, has addressed various important aspects of brain injury and neurodegeneration, such as TBI, cerebral hypoxia, epilepsy, AD, and SARS-CoV-2-mediated brain damage. It received appreciable global response, and published 18 peer-reviewed articles, including 10 research articles and 8 reviews. Briefly, it explores the recent coronavirus infection-mediated cerebral damage; discusses the mechanism of TBI, ischemia, hypoxia, and epilepsy; talks about neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and CONDCA; and, finally, reviews the translational values of phytochemicals in brain pathologies. In conclusion, this Special Issue provides a unique review on brain injury and neurodegeneration, and will be a good tool in enhancing knowledge in terms of brain disease-related pathology, mechanisms, and translational approach.
    Keywords: neurodegenerative diseases ; phytochemicals ; natural products ; neuroprotection ; neurotrauma ; neuroinflammation ; excitotoxicity ; oxidative stress ; apoptosis ; edema ; brain injury ; therapeutic strategies ; 18F-FDG PET ; anosmia ; COVID-19 ; SARS-CoV-2 ; olfactory dysfunction ; anti-convulsants ; anti-epileptic drugs ; drug targets ; epileptogenesis ; non-communicable disease ; seizures ; transcriptional modifications ; pseudo-resistance ; ischemia ; FABP3 ; FABP5 ; FABP7 ; mPGES-1 ; PGE2 ; treadmill exercise ; Parkinson’s disease ; neural mitochondrial functions ; amyloid beta ; Alzheimer’s disease ; inflammation ; gene regulation ; organelle dysfunction ; AGTPBP1 ; CCP1 ; CONDCA ; neurodegeneration ; NNA1 ; pcd ; microglia ; chronic alcoholism ; HHV-6 ; Substantia Nigra ; ischemic stroke ; epigenetics ; histone deacetylase ; histone deacetylase inhibitor ; mechanical stimulations ; traumatic brain injury (TBI) ; stretching ; neurons ; GSK-3β ; p-Tau ; extracellular matrix ; icariin ; icaritin ; middle cerebral artery occlusion ; traumatic brain injury ; blunt-force TBI ; post-traumatic seizures ; zebrafish ; sonic hedgehog signaling ; purmorphamine ; mild traumatic brain injury ; microRNA ; exomiRNA ; exosome ; TBI ; tRNA ; miRNA ; isomiR ; RNAseq ; moderate traumatic brain injury ; reactive oxygen species ; cognitive impairment ; mitochondria ; hypoxia ; neuraxis ; hypoxic-ischemic injuries ; neural ischemia ; neural tissue hypoxic injuries ; neuro-recovery ; neurorehabilitation ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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  • 116
    Publication Date: 2024-04-02
    Description: The ever-growing information and communications within society require us to continuously update our knowledge. For this reason, higher education must provide students and lecturers with the opportunity to implement new learning approaches in the classroom. In this sense, teaching is adapting to a fast-changing world, and achieving a high-quality standard for our educational systems will ensure that the education standard appropriately adapts to both the current times and to new teaching–learning processes. This topic captures the attention of different socio-educational actors in order to achieve an education style that develops individuals and provides them with the necessary strategies to assist their learning throughout their lifetime.
    Keywords: higher education ; inclusive education ; disability ; technological platforms ; faculty members ; international students ; service quality evaluation ; perceived satisfaction ; sustainable higher education system ; China ; active learning ; career adaptability ; Hong Kong ; human resources management ; university students ; university teaching ; mobile-assisted language learning ; foreign language learning ; productive-receptive skills ; technology acceptance model ; WhatsApp ; Line App ; VET ; European ; validation principles ; Spain ; virtual meeting platform ; technology readiness ; social presence ; course satisfaction ; sustained use intention ; serial mediation ; science scenario ; collaborative problem solving ; behavioral transition patterns ; lag sequential analysis ; disadvantaged students ; higher education SPROUT project ; learning effects ; qualitative changes ; distance learning ; university authorities ; lecturers ; students ; cross-cultural pragmatic competence ; social context ; communicative dynamics in classroom situations ; EFL context ; online instruction ; students’ perceptions ; education quality ; online learning ; socioemotional competence ; models ; emotional intelligence ; social intelligence ; TAM Model ; learning analytics ; academic performance ; COVID-19 ; middle school students ; parenting style ; self-esteem ; academic achievement ; academic engagement ; social emotions ; performance ; performance enhancement ; performance anxiety ; psychological flexibility ; ACT ; transdiagnostic approach ; transdiagnostic assessment ; transdiagnostic interventions ; transdiagnostic dimensions ; psychopathology ; mental health ; health conditions ; emotional disorders ; implementation ; dissemination ; cost-effectiveness ; prevention ; evidence-based psychological interventions ; sustainable education ; learning environments ; active learning classrooms ; informal learning ; student perceptions ; educational quality ; dropout ; permanence ; public policies ; institutions ; modelling ; learning stories ; early childhood curriculum ; program evaluation ; workstation design ; online classes ; user preference ; conjoint analysis ; grade retention ; psychosocial outcomes ; school retention composition ; quasi-experimental methods ; multilevel modelling ; PISA ; teacher self-regulation ; student self-regulation ; secondary education ; quantitative study ; engagement ; sense of belonging ; social support ; freshmen ; university ; virtual campus ; quality ; virtual education ; digital environments ; first-year students ; student adjustment ; marketing research ; evolution ; university subject ; professors ; professionals ; data ; technology ; critical thinking ; assessment ; quality education ; n/a ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JN Education
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  • 117
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Since the emergence of the Coronavirus-19 infectious disease (COVID-19) pandemic, a rising number of reports have underlined the risk of increasing antimicrobial resistance due to antibiotic overuse in COVID-19 patients. In addition, many physicians and pharmacists involved in antimicrobial stewardship have had to shift their activities to the containment of the COVID-19 crisis. In contrast to this observed overconsumption of antibiotics, very few bacterial superinfections have been documented in COVID-19 patients, especially in patients admitted outside the intensive care unit and in the first days of admission. However, the identification of bacterial co-/superinfections in COVID-19 patients is difficult, as inflammatory and radiological markers of bacterial infection lack specificity in this setting. Furthermore, studies regarding the effect of immune suppression, including the use of corticosteroids and anti-interleukins, and the effect of potential immunomodulatory properties of certain antibiotics on the occurrence of bacterial co-/superinfection are needed.This Special Issue of Antibiotics aims to increase our knowledge regarding (more or less specific) markers associated with bacterial co-/superinfection in COVID-19 patients, quantitative and qualitative data regarding antibiotic prescriptions in COVID-19 patients, potential beneficial effects of antibiotic use in certain COVID-19 subgroups, detrimental effects associated with antibiotic overuse in COVID-19 patients, and evidence-based guidelines, which could facilitate the decision-making process when antibiotic prescriptions are considered.
    Keywords: COVID-19 ; antimicrobial use ; multicentre ; point-prevalence study ; Influenza ; co-infection ; secondary infections ; aspergillosis ; ivermectin ; randomized-controlled trial ; prevention ; treatment ; SARS-CoV-2 ; antiviral ; antibiotic ; azithromycin ; remdesivir ; macrolides ; virus ; coronavirus ; immunolides ; antivirus ; pandemics ; procalcitonin ; SARS virus ; community-acquired infections ; emergency service ; hospital ; pneumonia ; viral ; community-acquired pneumonia ; Mid-regional Pro-adrenomedullin ; ARDS ; biomarker ; prognosis ; superinfection ; bacterial co-infection ; bacterial superinfection ; antibiotic stewardship ; AMR ; antibiotics ; cephalosporin ; secondary infection ; variant of concern ; interleukin-6 receptor antagonist ; early administration ; mortality rates ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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  • 118
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-30
    Description: The purpose of this Special Issue is to show progress regarding current research and literature on the theme of “Current Trends in Tourism under COVID-19 and Future Implications for Sustainability”. In particular, this Special Issue of the peer-reviewed international journal Sustainability aspires to expand the discussion and scientific debate on a range of viewpoints, trends, approaches, cases, impacts, challenges, models, and/or frameworks relating to tourism in the time of COVID-19, as well as the possibility of implementing the principles of sustainable tourism development in the post-pandemic period. Restarting the frozen tourism economy is an opportunity to build healthy relations between various groups of tourism stakeholders, including entrepreneurs and tourists. "New tourism" also requires legal and organizational solutions in order to balance the economic relations between global and local market actors in terms of consumer protection, as well as prevent the phenomenon of overtourism. The digitization of tourism services in the areas of marketing and sales should be one of the priorities addressed by entrepreneurs and DMOs. In the literature, as well as in the media and the scientific community, the impact of the pandemic on tourism has been the most commonly discussed topic over the last two years. This Special Issue aims to explore further sustainable tourism practices.
    Keywords: pandemic fatigue ; travelers’ fear of missing out (FOMO) ; destination crisis marketing ; post-COVID-19 tourism ; vaxication intention ; greatest of all trips (GOAT) ; international expats ; theory of planned behavior ; cognitive load theory ; protection motivation theory ; COVID-19 ; safety ; tourism branding ; health-protective behavior ; Greece–Spain ; customer satisfaction ; P2P accommodation market ; exploratory factor analysis ; service quality ; tourism ; impact ; DMO ; support tools ; hotel ; OCC ; ADR ; RevPAR ; revenue management ; Poland ; stakeholder ; social capital ; pandemic ; collective action ; community adaptation ; SEM analysis ; resilience ; absorption ; SARS-CoV-2 ; Tyrol ; marketing ; marketing mix ; crisis management ; COVID-19 epidemic ; catering industry ; restaurants ; risks ; stigmatized ; destinations ; Serbia ; youth ; students ; tourist activity ; COVID-19 pandemic ; trends ; perspectives ; contemporary tourism ; risk perceptions ; travel intentions ; personality traits ; market segmentation ; sustainable tourism ; tourism industry ; sustainable recovery ; health crisis ; tour operator ; travel package ; linked travel arrangements ; insolvency ; destination management organizations ; tourism technology ; content analysis ; thematic analysis ; smart tourism destination ; smart city ; sustainable development ; systematic literature review (SLR) ; research agenda ; package holiday ; tourist decision-making ; tourist behavior ; tourism sustainability ; Masai Mara ; policy interventions ; Kenya ; bibliometric study ; VOS viewer ; R bibliometrix ; government subsidies ; perceived quality ; perceived behavioral control ; predicted risks ; travel intention ; behavioral intention ; online digital exhibition ; competence ; meetings industry ; management ; post-COVID ; museums in a pandemic ; new technologies in museums ; traditional cultural participation ; Madeira ; population density ; correlation significance analysis ; k-means clustering ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCZ Economic history
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  • 119
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The effects of nutrition on chronic conditions, such as diabetes, obesity, heart disease, and stroke, continue to generate interest among researchers. This is because diet is a modifiable risk factor. The composition of diet, including the proportions and types of macronutrients and micronutrients, is a major contributor to chronic diseases. The beneficial effects of nutritional interventions on chronic conditions have been well documented, although differences remain among researchers concerning their overall impact. The evaluations of the role of nutrition in chronic conditions draw on diet’s effects on body weight, body composition, glycemic, and insulin excursions, and vascular remodeling. The effect of diet in modulating gut microbiota dysbiosis is also an evolving area of research. This reprint, entitled “Nutrition in Chronic Conditions”, aims to examine the effect of nutrition in the development, care, and management of chronic conditions. This reprint includes 11 original studies conducted in high- and middle-income countries, 3 systematic reviews with meta-analysis, and 3 literature reviews. The topics covered in the reprint include: the effects of diet on (1) insulin and glucose metabolism; (2) gut health; (3) brain and cognitive impairment; (4) infections, chronic conditions, malnutrition, and all-cause mortality; (5) obesity and dietary variables in post-menopausal women; (6) non-alcoholic fatty liver disease in mice, specifically with the consumption of coffee; and (7) chronic conditions and COVID-19 infection.
    Keywords: metabolic syndrome ; insulin resistance ; diabetes mellitus type 2 ; mild cognitive impairment ; Alzheimer’s disease ; NAFLD ; coffee ; lncRNA ; Gm16551 ; H19 ; diabetes ; chronic kidney disease ; proteinuria ; inflammation ; diet ; nutrition ; plant-based foods ; medical nutrition therapy ; type 2 diabetes ; almonds ; tree nuts ; glycated haemoglobin ; gut microbiota ; body mass index ; bone metabolism ; obesity ; osteoporosis ; fracture ; bone turnover markers ; economic analysis ; chronic heart failure ; nutritional support ; clinical outcomes ; cost savings ; COVID-19 ; micronutrients ; deficiency ; SARS-CoV-2 ; hospital outcomes ; childhood obesity ; pandemic ; personalised lifestyle intervention ; overweight ; BMI ; extract of Ginkgo biloba (EGb) ; innate immunity ; PBLs ; cytokines ; handgrip strength ; malnutrition ; cancer ; glycemic control ; intake ; adolescents ; glycemic index ; glycemic load ; dietary fiber ; mortality ; cardiovascular diseases ; cohort study ; beta-hydroxybutyrate ; evolution ; ketogenesis ; anti-inflammatory ; zinc deficiency ; inflammatory bowel disease ; meta-analysis ; dietary habits ; Helicobacter pylori ; socio-demographic factors ; biochemical measurement ; vitamin D ; Bahrain ; postprandial ; hypertension ; insulinaemia ; triglyceridaemia ; prebiotics ; oral anti-diabetic agents ; gut microbiome ; Network meta-analysis ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC4 Cultural studies: food and society
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: This Special Issue aimed to cover a diverse scope of topics, from diagnostics to the management of temporomandibular disorders and myofascial pain, with a special focus on innovations in those areas. Intense research progress in the subject as well as technological development, access to knowledge, and novel digital tools allow developing more precise, reproducible, and dedicated diagnostic and therapeutic protocols.
    Keywords: temporomandibular disorders ; arthralgia ; sodium hyaluronate ; betamethasone ; platelet-rich plasma ; mastication ; bite force ; alloplastic total joint replacement ; temporomandibular joint ; facial pain ; telemedicine ; community dentistry ; public health dentistry ; COVID-19 ; temporomandibular joint disorders ; temporomandibular joint dysfunction syndrome ; musculoskeletal manipulations ; manual therapies ; systematic review ; dental occlusion ; dental prosthesis ; trigger points ; myofascial pain ; manual therapy ; botox ; botulin toxin therapy ; masticatory dysfunction syndrome ; pilot study ; feedback ; muscle strength ; neurofeedback ; rehabilitation ; reproducibility of results tongue ; arcon articulator ; condylar guidance angle ; non-arcon articulator ; panoramic radiographs ; radiographic examination ; novel diagnosis ; temporomandibular dysfunction ; therapeutic ; lateral spread response ; abnormal muscle response ; hemifacial spasm ; microvascular decompression ; compressive patterns ; penetrating offender ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The main difficulty of radiotherapy is to destroy cancer cells without depletion of healthy tissue. Stem cells and cancers are tightly interrelated. On one hand, radiosensitivity/radioressistance of cancer stem cells affects the radiocurability of tumors. On the other hand, radiosensitivity is responsible for the stem cell depletion of organs at risk exposed to irradiation. Efficient solide cancer destruction is limited by the preservation of organ homeostasis. For this reason, targeted irradiation is an effective cancer therapy, but damage inflicted to normal tissues surrounding the tumor may cause severe complications. The consequences of stem cell depletion of healthy tissue irradiated are acute and chronic radiation diseases. Research on the radiosensitivity of cancer stem cells and adult stem cells associated with tissue regeneration medicine will bring forth the solution for optimal radiocurability associated with long-term patients’ quality of life.
    Keywords: human epidermis ; keratinocytes ; stem cells ; precursor cells ; low-dose γ irradiation ; regeneration ; dysplasia ; epithelial-to-mesenchymal transition (EMT) ; ZEB1 ; experimental radiotherapy ; radiobiology ; mesenchymal stem cells ; cell therapy ; exosome ; annexin A1 ; acute respiratory-distress syndrome ; COVID-19 ; local radiation injuries ; conditioned medium ; cell technologies ; X-ray radiation ; skin ; placenta ; Radiation ; stem/progenitor cells ; organoids ; radiation therapy ; radiation cystitis ; fibrosis ; treatment ; stem cells therapy ; macrophages ; mesenchymal stem cell ; radiation damage ; BCSC ; ALDH activity ; fractionated dose of γ radiation ; radioresistance ; ROS ; Nrf2 ; Keap1 ; miR200a ; epithelial–mesenchymal transition (EMT) ; colorectal cancer ; cancer-stem like cells ; SOX2 ; PI3K/AKT ; radiation-induced injury ; radiotherapy ; radiation ; mesenchymal ; stem cell ; extracellular vesicles ; micro vesicles ; paracrine effect ; adipose tissue derived stem cells ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 122
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-30
    Description: The topic of the reprint is very important nowadays, because ever-evolving machine learning techniques make it possible to obtain better real-world data. Therefore, this reprint contains information related to real data in fields such as automatic sign language translation, bike-sharing travel characteristics, stock index, sports data, fake news data, and more. However, it should be noted that the reprint also contains a lot of information on new developments in machine learning, new algorithms, algorithm modifications, and a new measure of classification quality assessment that also takes into account the preferences of the decision maker.
    Keywords: machine learning ; optical networks ; imbalanced data ; one-class classification ; entropy measure ; real-world data ; preprocessing ; decision table ; classification ; query set ; decision tree ; differential cryptanalysis ; metaheuristics ; symmetric block ciphers ; memetic algorithms ; DES ; simulated annealing ; COVID-19 ; vaccination ; agent-based modelling ; dynamic stochastic general equilibrium models ; scenario analyses ; validation of results ; stock index forecasting ; CEEMDAN ; ADF ; ARMA ; LSTM ; hybrid model ; classification measure ; quality of classification ; quality measure ; preference-driven classification ; fast iterative filtering ; parameter adaptive refined composite multiscale fluctuation-based dispersion entropy ; rotating machinery ; fault diagnosis ; short-term demand prediction ; bike-sharing ; travel characteristics analysis ; hybrid TCN-GRU model ; distributed data ; decision tables ; information systems ; decision trees ; decision rules ; tests ; reducts ; association rules ; Pawlak conflict analysis model ; independent data sources ; coalitions ; dispersed data ; length ; support ; greedy heuristics ; feature selection ; rough sets ; action units ; automatic translation ; sign language ; entropy of real data ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNT Media, entertainment, information and communication industries::KNTX Information technology industries ; thema EDItEUR::U Computing and Information Technology::UY Computer science
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  • 123
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint, as a continuation of a previous Special Issue entitled “Efficiency and Optimization of Buildings Energy Consumption”, gives an up-to-date overview of new technologies based on Machine Learning (ML) and Internet of Things (IoT) procedures to improve the mathematical approach of algorithms that allow control systems to be improved with the aim of reducing housing sector energy consumption.
    Keywords: ventilation ; energy ; COVID-19 ; procedure ; building ; ISO ; energy consumption ; building construction ; Passivhaus ; affordable housing ; neural network ; LSTM ; MLP ; thermal inertia ; building performance ; artificial intelligence ; artificial neural network ; demand-side management ; evolutionary computing ; non-intrusive appliance load monitoring ; parallel computing ; smart grid ; smart house ; cellular concrete ; lightweight materials ; thermal conductivity ; electricity ; dynamic simulation ; housing ; climate change ; weather controlled central system ; energy saving ; thermal improved of buildings ; new energy technologies ; sustainable buildings ; energy efficiency ; heat loss coefficient ; machine learning ; XGBoost ; SVR ; load disaggregation ; multi-scale ; attention mechanism ; residual network ; energy savings ; daylighting ; photovoltaic system ; EnergyPlus ; Homer PRO ; Net Zero Energy Buildings ; solar radiation ; support vector machine ; heuristic algorithm ; renewable energy ; solar energy systems ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PH Physics
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book brings together all 16 articles published in the Special Issue "Applied Mathematics to Mechanisms and Machines" of the MDPI Mathematics journal, in the section “Engineering Mathematics”. The subject matter covered by these works is varied, but they all have mechanisms as the object of study and mathematics as the basis of the methodology used. In fact, the synthesis, design and optimization of mechanisms, robotics, automotives, maintenance 4.0, machine vibrations, control, biomechanics and medical devices are among the topics covered in this book. This volume may be of interest to all who work in the field of mechanism and machine science and we hope that it will contribute to the development of both mechanical engineering and applied mathematics.
    Keywords: path generation ; dimensional synthesis ; hybrid optimization ; slider-crank mechanism ; hybrid compliant mechanisms ; path analysis ; numerical methods ; elliptic integrals ; kinematics ; Levenberg–Marquardt algorithm ; convergence ; neural networks ; local minima ; optimization ; three-legged parallel mechanism ; compliant mechanism ; flexure-based mechanism ; flexure ; compliant joint ; decoupled motion ; coupled motion ; stiffness ; compliance ; suspension algorithm ; predictive suspension ; land vehicle ; sprung mass ; autoencoder ; aeroengine ; denoising ; GRU ; rotordynamic ; adaptive rejection control ; sinusoidal disturbance ; flexible rotor ; hydrodynamic journal bearing ; six-bar mechanism ; dynamic balancing ; fully Cartesian coordinates ; multiobjective optimization ; differential evolution ; Pareto front ; serial robotic manipulators ; singularity identification ; geometric algebra ; rotor group ; distance to a singularity ; air flow medical sensor ; emergency air flow sensor ; low-cost air flow sensor ; nanostructures ; COVID-19 ; FEM analysis ; biomechanics ; effort mathematical models ; NMR reconstruction ; reverse engineering ; elbow joint ; zipper-coupled tubes ; Miura-ori pattern ; deployable mechanism ; origami inspired design ; smooth sheet attachment ; relative rotation ; jump ; safe basin ; fractal ; heteroclinic bifurcation ; delayed feedback ; helical spring ; vibration ; Frenet trihedral ; dispersion relation ; natural frequency ; approximate entropy ; non-linear systems ; phase space reconstruction ; fault classification ; random forest ; support vector machines ; lateral dynamics ; track parameters ; vehicle mathematical modeling ; safety vehicle index ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 125
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Since the emergence of the Coronavirus-19 infectious disease (COVID-19) pandemic, a rising number of reports have underlined the risk of increasing antimicrobial resistance due to antibiotic overuse in COVID-19 patients. In addition, many physicians and pharmacists involved in antimicrobial stewardship have had to shift their activities to the containment of the COVID-19 crisis. In contrast to this observed overconsumption of antibiotics, very few bacterial superinfections have been documented in COVID-19 patients, especially in patients admitted outside the intensive care unit and in the first days of admission. However, the identification of bacterial co-/superinfections in COVID-19 patients is difficult, as inflammatory and radiological markers of bacterial infection lack specificity in this setting. Furthermore, studies regarding the effect of immune suppression, including the use of corticosteroids and anti-interleukins, and the effect of potential immunomodulatory properties of certain antibiotics on the occurrence of bacterial co-/superinfection are needed.This Special Issue of Antibiotics aims to increase our knowledge regarding (more or less specific) markers associated with bacterial co-/superinfection in COVID-19 patients, quantitative and qualitative data regarding antibiotic prescriptions in COVID-19 patients, potential beneficial effects of antibiotic use in certain COVID-19 subgroups, detrimental effects associated with antibiotic overuse in COVID-19 patients, and evidence-based guidelines, which could facilitate the decision-making process when antibiotic prescriptions are considered.
    Keywords: COVID-19 ; antimicrobial use ; multicentre ; point-prevalence study ; Influenza ; co-infection ; secondary infections ; aspergillosis ; ivermectin ; randomized-controlled trial ; prevention ; treatment ; SARS-CoV-2 ; antiviral ; antibiotic ; azithromycin ; remdesivir ; macrolides ; virus ; coronavirus ; immunolides ; antivirus ; pandemics ; procalcitonin ; SARS virus ; community-acquired infections ; emergency service ; hospital ; pneumonia ; viral ; community-acquired pneumonia ; Mid-regional Pro-adrenomedullin ; ARDS ; biomarker ; prognosis ; superinfection ; bacterial co-infection ; bacterial superinfection ; antibiotic stewardship ; AMR ; antibiotics ; cephalosporin ; secondary infection ; variant of concern ; interleukin-6 receptor antagonist ; early administration ; mortality rates ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 126
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Plants produce a wide range of phytochemicals, known as non-nutrition compounds, to confirm their identity, and they are used for the production of natural pharmaceuticals, cosmetics, and functional food, among other things, due to their pro-health properties. The use of modern chromatographic techniques allows for accurate quantitative and qualitative identification of the above-mentioned phytochemicals and their natural products. Liquid chromatography is one of the most efficient and robust specific techniques due to the merits of convenience and strong separation ability, as well as a wide range of material applications for identification. Liquid chromatography is widely used to analyze plants, nutraceuticals, pharmaceuticals, and cosmetics and in natural product quality control or quantitative determination of bioactive compounds. The most commonly used for identifying different plant materials and pharmaceuticals are ultra- and high-performance liquid chromatography with UV-VIS, fluorescence, and diode array, which is equipped with mass spectrometry or tandem mass spectrometry detection methods. Therefore, for this Special Issue, we published studies concerning the latest scientific news, insights, and advances in the field of innovation of liquid chromatography for the analysis of bioactive compounds for pharmaceuticals, cosmetics, and functional food interests.
    Keywords: antibiotics ; food safety ; oral fluid ; pigs ; UHPLC-MS/MS ; dietary supplement ; food supplement analysis ; LC-MS/MS ; release test ; quality control ; food composition ; pentacyclic triterpenoids ; plant feedstock ; supercritical fluid chromatography ; tandem mass spectrometry ; bioactive compounds ; in vitro biological potency ; medical plant ; marsh woundwort ; clover sprouts ; Trifolium ; isoflavones ; prostate cancer ; breast cancer ; cytotoxic ; COVID-19 ; HPLC-UV ; quality control of Umckaloabo ; Pelargonium sidoides root extract ; umckalin ; Astragalus fruticosus ; HPLC–MS/MS profiling ; colorectal cancer ; cytotoxic activity ; contezolid ; CSF ; plasma ; capillary electrophoresis ; mass spectrometry ; online preconcentration ; stacking ; tyrosine kinase inhibitors ; tiamulin ; withdrawal time ; Crocus sativus L. ; phorone ; crocins ; picrocrocin ; safranal ; DPPH ; FRAP ; total antioxidant capacity ; antimicrobial activity ; anticoagulant activity ; antidiabetic activity ; Allium cepa L. ; direct thermal desorption–gas chromatography–mass spectrometry ; multi-response optimization ; onion ; organosulfur compounds ; LC-MS ; tissue ; morphine ; fentanyl ; opioids ; antipsychotic drug LQFM05 ; sample pretreatment ; tissue distribution ; bioanalytical methods ; LC-QTOF/MS ; antioxidants ; radioresistant microorganisms ; radioprotection ; biofilm ; co-operative growth ; oxidative stress ; chlorogenic acids ; ion trap MS analyzer ; isomers recognition ; ERMS ; solid-phase extraction ; CDK4/6 inhibitors ; therapeutic drug monitoring ; liquid chromatography ; bioanalysis ; patient plasma ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-30
    Description: Sensors used to diagnose, monitor or treat diseases in the medical domain are known as medical sensors. There are several types of medical sensors that can be utilized for various applications, such as temperature probes, force sensors, pressure sensors, oximeters, electrocardiogram sensors that measure the electrical activity of the heart, heart rate sensors, electroencephalogram sensors that measure the electrical activity of the brain, electromyogram sensors that record electrical activity produced by skeletal muscles, and respiration rate sensors that count how many times the chest rises in a minute. The output of these sensors used to be interpreted by humans, which was time consuming and tedious; however, such interpretations became easy with advances in artificial intelligence (AI) techniques and the integration of the sensor outputs into computer-aided diagnostic (CAD) systems. This reprint presents some of the state-of-the-art AI approaches that are used to diagnose different diseases and disorders based on the data collected from different medical sensors. The ultimate goal is to develop comprehensive and automated computer-aided diagnosis by focusing on the different machine learning algorithms that can be used for this purpose as well as novel applications in the medical field.
    Keywords: prostate cancer ; image processing ; histopathology images ; digital image analysis ; computational pathology ; artificial intelligence ; Nosema disease ; machine learning ; deep learning ; image ; disease detection ; blood flow velocity quantification ; conjunctival microvessel ; motion correction ; optical imaging system ; vessel segmentation ; transfer learning ; ALexNet ; VGGNet ; ADC maps ; computer-aided diagnosis ; convolutional neural networks ; diabetic retinopathy ; diabetic retinopathy classification ; diabetic retinopathy lesions localization ; YOLO ; thyroid ; cancer ; CNN ; MRI ; DWI ; radiomics ; BITalino ; BrainAmp ; ICC ; intraclass correlation coefficient ; Bland–Altman method ; big healthcare data ; classification ; decision-making ; feature selection ; whale optimization ; naive bayes ; renal cell carcinoma ; CE-CT ; morphology ; texture ; functionality ; RC-CAD ; electrocardiogram (ECG) ; affective computing ; emotion recognition system ; healthcare ; Alzheimer’s disease ; personalized diagnosis ; mild cognitive impairment ; sMRI ; U-NET ; uveitis grading ; OCT segmentation ; computed tomography (CT) ; lung ; chest ; segmentation ; COVID-19 ; autism ; ASD ; CWT ; dendritic cells ; electrical characterization ; immune system ; macrophages ; chest X-ray ; diagnosis ; POCUS ; multichannel system ; channel data ; bladder monitoring ; POUR ; machine-learning ; NC protein ; optical detection ; protein–protein interactions ; RBD ; SARS-CoV-2 ; grade groups ; CAD system ; chewing ; smart devices ; discrete wavelet decomposition ; low pass filter ; number of chews ; carotid intima-media thickness ; IMT ; CCA ; encoder-decoder model ; left ventricular assist devices ; sensor-based control ; pump independent ; suction index ; physiological perfusion ; suction prevention ; biomedical informatics ; cardiovascular disease ; ECG ; heart rate variability ; PPG ; smartphones ; smart wearables ; thermal camera ; non-contact spirometry ; artificial intelligence regression ; respiration signal ; respiration rate mobile application ; multiple object tracking ; data association ; dataset ; semantic attribute ; autism spectrum disorder (ASD) ; DTI ; neuroimaging ; ABIDE-II ; lung sound detection ; heart sound detection ; convolutional neural network ; model fusion ; multi-features ; texture analysis ; shape features ; functional features ; PSA ; osteoporosis ; strength training ; osteopenia ; bone mass ; DEXA ; diabetic retinopathy (DR) ; optical coherence tomography angiography (OCTA) ; convolutional neural networks (CNN) ; image encryption ; security analysis ; convolutional neural network (CNN) ; brain imaging ; machine learning (ML) ; cervical cancer ; human papillomavirus (HPV) ; gradient boosting ; support vector machine (SVM) ; skin lesions ; skin cancer ; melanoma ; image classification ; Diabetic Retinopathy ; fundus images ; lesions detection ; n/a
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: The reprint provides a comprehensive review of various topics related to sustainable building design and operation, with a particular focus on energy efficiency and environmental impact. It covers a wide range of topics, including visual comfort assessment, decision-making processes of residents, low-cost devices for CO2 monitoring, and the impact of the COVID-19 pandemic on residential energy use. The reprint also includes discussions on solar energy in urban planning, cost-optimal measures for energy renovation, and passive solar solutions for buildings. It provides insights into the use of different materials and strategies for improving the energy efficiency of building envelopes, including the integration of phase change materials and the use of reflective coatings on building roofs. Several case studies are presented in the book, which explores the implementation of sustainable design strategies in different building types and climates. The authors also discuss the use of advanced modeling techniques to simulate the performance of different building systems, including vertical greenery systems and the solar cadaster.
    Keywords: bidirectional gated recurrent unit ; convolutional neural networks ; electricity consumption prediction ; hybrid deep learning model ; residential load prediction ; solar energy ; building energy performance ; energy saving ; passive solar design ; synergistic design ; risk assessment ; climate change ; health ; heat stress ; AQI ; solar reflective coatings ; heat transfer ; daily heat gains ; cool roofs ; residential energy modeling ; COVID-19 ; coronavirus pandemic ; temperature sensitivity ; energy security ; phase change material ; thermal energy storage ; energy efficiency ; passive strategies ; active strategies ; adaptive envelopes ; Vertical Greenery Systems (VGS) ; classification ; comparison of different types of VGS ; mathematical modeling and thermohygrometric analysis ; EnergyPlus ; public school buildings ; optimal cost ; energy renovation ; public buildings ; solar cadaster ; solar potential modeling ; numerical validation ; heritage values ; user ; sustainability ; thermal comfort ; heritage buildings ; decision-making ; preservation ; Mexico City ; urban planning ; active solar systems ; passive solar strategies ; Italian case studies ; agrivoltaics ; visual comfort ; lighting ; daylight ; user centred design ; modeling ; monitoring ; indoor air quality (IAQ) ; smart building ; sustainable development goals (SDGs) ; CO2 ; refurbishment ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-30
    Description: The theme of entrepreneurship in the post-pandemic context is essential for the economic and social revitalization of economies. Despite this importance, this theme has hardly been explored, and therefore one of the central aspects of this reprint is to bring the debate on the competitiveness of micro-, small-, and medium-sized enterprises in various sectors to academic discussion. Through 11 chapters, involving the collaboration of more than 30 authors, this reprint pragmatically discusses a wide range of strategies and critical success factors for fostering entrepreneurship. This reprint also presents a set of practical solutions for various sectors, from tourism to agriculture, covering several countries, from Latin America to Asia to Europe. The various chapters present very diverse methodological approaches.
    Keywords: barriers to innovation ; innovative performance ; product innovation ; process innovation ; innovation ; entrepreneur ; self-confidence ; Venezuelan migration ; taking risks ; seizing opportunities ; Colombia ; post-pandemic ; COVID-19 ; Can Tho city ; resilience ; mitigation ; Vietnam ; drive tourism ; routes ; sustainable ; systematic literature review ; PRISMA ; entrepreneurial self-efficacy ; social entrepreneurial self-efficacy ; innovativeness ; organizational capabilities ; philanthropic CSR ; tourism lifestyle entrepreneurs ; surf ; life satisfaction ; networking ; financial objectives ; Azores ; canyoning ; entrepreneurship ; tourism ; hospitality sector ; soft skills ; hard skills ; human resources ; workers’ perceptions ; COVID-19 pandemic ; comparative study ; empowerment ; human capital ; economic capital ; financial capital ; level of ability of business actors in the agricultural sector ; tourism entrepreneurship ; digital nomads ; self-efficacy ; SMEs ; Latin American entrepreneurship ; COVID-19 economic crisis ; n/a ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJC Business strategy
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  • 130
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-30
    Description: The articles discussed in this reprint show the potential health benefits of nutraceuticals, which are products containing bioactive compounds that can prevent and treat chronic diseases. This book explores various functional ingredients, including plant-derived products, mushrooms, microalgae, and goji berries, for their therapeutic, hypoallergenic, and sporting purposes. The study of the gut microbiome and its interactions with dietary components is also discussed. Additionally, the importance of sustainable and environmentally friendly practices in the food industry also stands out. As consumers seek out natural and functional food products, continued research on and the development of nutraceuticals will be critical in promoting healthy aging and addressing chronic diseases.
    Keywords: goji berry ; functional foods ; antioxidant ; health ; antibacterial ; health promotion ; chitosan ; high-fat diet ; hyperlipidemia ; dyslipidemia ; cardiovascular diseases ; obesity ; Basidiomycetes-X (BDM-X) ; Shirayukidake ; Ceraceomyces tessulatus ; Mibyou ; Mibyou-care functional food ; healthy lifespan expenditure ; buckwheat ; fava bean ; hemp ; anthocyanin ; flour fortification ; functional food ; berries ; soft fruit ; agricultural waste ; bilberry ; anti-allergy ; Coriandrum sativum L. ; cedar pollen ; degranulation ; RBL-2H3 cell ; coriander leaf ; antioxidants ; aging theories ; cohort study ; healthy diet ; longevity ; nutraceuticals ; oxidative stress ; reactive oxygen species ; senescence ; vitamins ; fruit ; food ; sugar ; athlete ; comfort ; mucilages ; ecological functions ; human and animal health-promoting properties ; application in agriculture ; genes ; nutritional components ; quercetin ; docosahexaenoic acid ; pectin ; polymeric conjugate ; biological properties ; anti-inflammation ; antioxidant activity ; chronic disease ; diabetes ; phenols ; testa ; prebiotic ; alginate ; alginate oligosaccharides ; intestinal microbiota ; microbial metabolites ; short-chain fatty acids ; colon simulation ; European black elderberry extract ; natural substance ; anthocyanins ; phenolic compounds ; SARS-CoV-2 ; antiviral ; COVID-19 ; coronavirus ; SARS-CoV-2 variants of concern ; microalgae ; mitochondria ; PUFA ; carotenoids ; sterols ; polyphenols ; chronic diseases
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-14
    Description: Available research has indicated a decline in physical fitness and motor competence over the last several decades. Movement restrictions and policies that have emphasized social distancing, due to the recent COVID-19 pandemic, may have further increased the prevalence of youth with insufficient physical fitness and motor competence. As physical fitness and motor competence are critical contributors to an active and healthy lifestyle, it is important to re-emphasize their role in the general health and development of children and adolescents and, accordingly, future public health. Particularly with the re-opening of schools, sports clubs and public parks, the promotion of activities that enhance physical fitness and motor competence in children and adolescents is warranted. This reprint highlights the importance of physical fitness and motor competence for the health and well-being of children and adolescents, by providing an interdisciplinary platform for research addressing this topic.
    Keywords: childhood obesity ; health-related quality of life ; self-concept ; self-perception ; physical fitness ; psychosocial health ; overweight ; obesity ; youth ; cardiorespiratory fitness ; muscular strength ; BMI percentile ; motor competence ; SARS-CoV-2 ; adolescent fitness ; young athletes ; outdoor sport ; horse riding ; perceived health ; structured sport activities ; screen time ; 0th-period physical education class ; adolescent ; parents ; Q-methodology ; subjectivity ; motor skills ; child ; Test of Gross Motor Development ; sex differences ; motor performance ; motor development ; effects ; influences ; cross-sectional study ; kindergarten ; sport ; health ; physical education ; well-being ; COVID-19 ; adult group ; fitness APP ; influencing factors ; sleep quality ; puberty ; sleep disorders ; physical condition ; insomnia ; sleepiness ; body fat ; lean body mass ; school ; teaching ; coaching ; thema EDItEUR::W Lifestyle, Hobbies and Leisure
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The interrelationship between economic growth, efficient use of natural resources, and sustainability has been of great interest to economists, researchers and policy makers. Knowledge of actual causality direction between sustainability, efficiency and growth has important implications for modeling environmental economic policies. Various serious environmental problems demand urgent attention and planning of adequate policies towards sustainability. Development of new economic and environmental policies and use of new econometric, operational research and mathematical and statistical techniques offers scope for further research. Studies were invited to address economic growth and environment: environmental problems; Air/water pollution; Health impact of pollution; Waste management; Natural resources management; Population economics; Environmental policy tools; Renewable energy sources; Business and sustainable development; Sustainable transport; Sustainable tourism; Urban and regional development.
    Keywords: budgeting analysis ; rural household income ; medicinal plants ; women ; sustainability ; Tobit regression ; system GMM ; acreage response ; yield response ; supply elasticity ; dynamic panel data approach ; major cereals ; Ethiopia ; space ; scale ; land degradation ; externalities ; indicators ; Italy ; resource rents ; human development ; development expenditure ; financial development ; economic growth ; co-integration ; VECM ; Sudan ; social cost ; environmental protection ; efficient voter rule ; environmental taxation ; EU ETS ; fiscal impact ; cluster analysis ; spatial patterns ; overlapping generations ; climate justice ; technology shock ; environmental quality ; OLG model ; intergenerational sustainability ; commons ; resource governance ; city logistics ; last-mile delivery ; sustainable development ; e-commerce ; COVID-19 ; environmental economics ; sustainable transport ; corporate sustainability ; corporate social responsibility ; economic results ; environmental responsibility ; social welfare ; oil and gas fields ; circular economy ; second-hand ; reuse ; transaction costs ; pollution control ; differential games ; trade agreements ; WTO ; climate change ; carbon dioxide emission ; literature review ; bic Book Industry Communication::K Economics, finance, business & management
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Global immunization rates were stagnating prior to the COVID-19 pandemic, and declined further in 2020 and 2021, with substantial variation. Across countries, the level of protection afforded by immunization varies, with many countries reporting gaps in coverage of Human Papilloma Virus (HPV) and seasonal influenza, and many population subgroups, especially children, being left behind. In this Special Issue, we explore the latest evidence on various types of immunization across the life course at global, regional, national, and subnational levels. Exploring various dimensions of inequality—such as economic status, subnational geographic regions, sex, maternal education—and other categories, this issue includes contributions characterizing the situation of inequality, the drivers of inequality, and finally, actions and initiatives that hold promise for enhancing equity of immunization across countries.
    Keywords: Inequality ; immunization ; COVID-19 ; child immunization ; zero dose ; health equity&nbsp ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: The COVID-19 pandemic is considered to be a global public health emergency. Due to its route of transmission via contact with droplets and aerosols, dentists are at high risk of acquiring an infection while treating patients. The impact of the coronavirus on the dental community is eminent, and the greatest challenge is how we can offer dental treatment despite the outbreak. Dental education programs in both under- and postgraduate forms will also suffer from the ramifications of the pandemic. This topical collection offers many perspectives on the management of the COVID-19 crisis within the dental community.
    Keywords: COVID-19 ; dentistry ; teleassistance ; remote sensing technology ; orthodontics ; teledentistry ; teleorthodontics ; SARS-CoV-2 ; dental care ; children ; dentist-patient relation ; pandemic ; oral oncology ; dental ; oral surgery ; head and neck cancer ; cancer patients ; oral manifestation ; xerostomia ; dysgeusia ; coronavirus pandemic ; temporomandibular disorders ; bruxism ; orofacial pain ; dental anxiety ; periodontitis ; bio-inspired ; nonsurgical periodontal therapy ; dental hygiene ; Angiotensin Converting Enzyme 2 (ACE-2) ; saliva ; inflammation ; oxidative stress ; dental practice ; n/a ; candidiasis ; critical care ; macroglossia ; oral manifestations ; pressure ulcer ; prone position ; oral health ; IES-R ; DASS-21 ; stress ; anxiety ; depression ; dentists ; psychological impact ; RT-PCR testing ; antigen ; antibody ; aerosols ; body fluids ; viral load ; epidemiological monitoring ; adverse effects ; BNT162 vaccine ; cross-sectional studies ; Czech Republic ; drug-related side effects and adverse reactions ; health personnel ; mass vaccination ; prevalence ; coronavirus ; resumption ; mitigating measures ; vaccination ; rapid testing ; Google Trends ; COVID-19 pandemic ; dental education ; OSPE ; communications skills ; remote ; surgery ; oral ; dental implantation ; retrospective studies ; population characteristics ; cross-sectional study ; oral cavity ; taste disorders ; maxillofacial injuries ; facial bone fractures ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-08
    Description: This collection of essays addresses a range of topics probing the interface between religious practice and the COVID-19 pandemic. Significant attention is given to religious and cultural debates over health care policy as well as vaccination policy development in the United States, but contributions from Africa, Asia, South America, and Europe are included as well. In addition to the North American perspectives (with an emphasis on the white evangelical Christian encounter with public health regulation), the volume highlights voices from Islamic Nigeria and southern Africa, traditional Confucian culture, Greek Orthodoxy, Catholic social teaching, as well as the insights of Haṭha yoga from the Hindu tradition.
    Keywords: COVID-19 ; public health ; religious practice ; vaccination policy ; vaccine hesitancy ; religious authority ; libertarianism ; other-regard ; moral decision-making ; rights to health care ; bic Book Industry Communication::H Humanities::HR Religion & beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: In times of rising polarization and disinformation at the global level, this reprint, “Geopolitics, Public Communication, and Social Cohesion Facing the Crisis of Democracy: Risks and Challenges”, explores the communication of the main conflicts that put integrity and geopolitics at risk. Drawing upon different methods, the contributions offer insightful findings on the role of communication by public institutions in crisis management and the actions of journalists and citizens. Therefore, this reprint furthers our understanding of how to deal with problems such as audiences’ distrust in politics, citizens’ disaffection with the media, and institutions’ loss of credibility.
    Keywords: trust ; social cohesion ; community ; low socio-economic ; South Africa ; far right ; emotions ; satisfaction with democracy ; climate change ; livestock ; meat consumption ; meat production ; cultivated meat ; media framing ; food transition ; food system ; Europe ; COVID-19 ; vaccination ; public communication ; polarization ; Twitter ; political communication ; criticism ; mobile instant messaging services ; Telegram ; Community of Madrid ; social media ; internet ; youth ; information ; women ; hate speech ; online violence ; constitutional process ; Chile ; platforms ; local media ; authorship ; audiences ; news ; disinformation ; LGBTQI+ ; LGBTQI+ organisations ; social audience ; activism ; pseudo-media ; communication ; Red Cross ; press ; reputation ; stakeholders ; Ukraine ; war ; logical fallacies ; digital pseudo-identification ; pseudo-authorities ; pseudo-statistics ; stereotypes ; Walter Lippmann ; agenda setting ; online misinformation ; mainstream media ; n/a ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
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  • 137
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-08-08
    Description: The experience of a good indoor environment can result in positive perceptual outcomes, which is related to the occupant’s well-being. Conversely, noise, uncomfortable temperatures and humidity, dim light, poor air quality, and pungent smells can compromise occupants’ life quality, negatively affect their place experience, or even reduce personal health. In order to ensure positive indoor environments for occupants, a perceptual quality assessment has been introduced and extensively studied in recent years. Influenced by indoor environmental quality (IEQ), it is necessary and beneficial to explore how humans perceive and what effects indoor environments. It is necessary for designers and researchers to address these issues associated with indoor environmental quality. Therefore, this Special Issue aims to gather articles that discuss indoor environmental quality and occupant comfort. The articles in this Special Issue encompass different research categories, ranging from conceptual analyses and reviews to research papers. These studies have investigated the characterization and perception of both individual indoor environments and complex environmental interactions, along with their management and design implications. The focuses of these investigations include both theoretical aspects (such as the relationships between environmental quality and psychological or physiological reactions) and methodological aspects (such as protocols and procedures of gathering objective and subjective data).
    Keywords: state arousal level ; visual comfort ; daylight illumination ; elderly persons ; reading behavior ; acoustic comfort ; speech transmission index ; speech intelligibility ; open-plan office ; thermal comfort ; PMV-PPD ; radiant floor ; cooling ; office buildings ; fan coil ; energy consumption ; lighting design ; lighting control system ; HDRi luminance analysis ; LabVIEW ; energy saving ; thermal environment ; cold regions ; university classroom ; heating season ; color psychology ; hotel indoor environment ; emotion ; subjective evaluation ; VR experiment ; rural houses ; winter ; ventilation ; waste heat recover ; air quality ; nursery ; classrooms ; vertical temperature difference ; humidity ; CO2 ; air stuffiness index ; particle matter ; illumination ; noise level ; elderly facility ; in-between area ; EEG ; HRV ; STAI ; architectural scheme design ; general demand analysis ; Kano model ; indoor navigation ; system design ; sunlight patterns ; aperture design ; immersive virtual reality ; ECG ; sky type ; decoration style ; text analysis ; questionnaire survey ; comparative study ; China ; blind older adults ; nursing homes ; acoustic environment ; sound perception ; aural diversity ; inclusive design ; COVID-19 ; classroom colour environment ; college students’ mental health ; HAD scale ; daylight simulation ; atrium ; corelighting ; heritage retrofit ; historical building ; indoor environmental quality ; view analysis ; Nordic latitude ; historical residential buildings ; passive cooling ; hotel interior spaces ; high sound insulation ; lightweight composite structure partition ; sound transmission loss ; annual daylighting performance ; atrium design ; parametric simulation ; primary and secondary school ; IEQ preferences ; psychosocial preferences ; twostep cluster analysis ; study place ; students’ profiles ; daylighting performance ; terrace classrooms ; interior space geometry ; window geometry ; severe cold regions ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Assessing the risk of difficult-to-treat bacterial superinfections, such as multidrug-resistant (MDR) Gram-negative bacilli, according to comorbidities, lung abnormalities or systemic diseases, the severity of pneumonia and the risks of drug-related effects are crucial points for the clinical management. Despite the wide—and not always appropriate—use of broad-spectrum antimicrobials, specific data about bacterial and fungal co-infection in COVID-19 patients are lacking, and confirmed evidence is urgently required to build prospective evidence and to support the development of antimicrobial policy and appropriate stewardship interventions. The present Special Issue aims to focus on the following key points: Importance of superinfections in COVID-19 patients who are typically characterized by immunosuppression related to viral infection, need for prolonged hospitalization, treatment with immunomodulatory therapies (steroids, monoclonal antibodies, etc.); Their impact on the outcome of a cohort of patients who are relatively young, with few comorbidities, but requiring prolonged invasive support; Incidence, characteristics and impact of bacterial infections caused by multidrug-resistant, Gram-negative pathogens in the context of COVID-19 disease; Incidence, characteristics and impact of fungal infections, such as the most known invasive aspergillosis but also candidemia and/or other fungal infections (e.g., mucormycosis); Antimicrobial surveillance, control and management measures as implemented on a local, national and international basis.
    Keywords: Superinfections ; COVID-19 ; SARS-CoV-2 ; multidrug-resistant pathogens ; antimicrobial stewardship ; antimicrobial resistance ; fungal infections ; bacterial infections ; intensive care medicine ; critical care medicine ; bic Book Industry Communication::M Medicine
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  • 139
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The present reprint contains all of the articles accepted and published in the Special Issue "Probability and Stochastic Processes with Applications to Communications, Systems and Networks" from the MDPI Mathematics journal. This Special Issue is devoted to probability, statistics, stochastic processes and their different applications in system and network analysis. The Special Issue includes works related to the analysis and applications of different queuing models, which begin with general approaches in modeling queuing systems and networks; an analysis of probabilistic and statistical methods in telecommunication; an asymptotic analysis of queuing networks in the condition of a large load; general complex networks and their structures, e.g., topology and graph theory; mathematical methods and models in smart cities; exclusive statistical methods, such as statistical estimates in bio/ecology, medicine and neural networks; and studies that estimate parameters in complex technical systems, etc. We hope that the scientific results collected in this reprint will help foster future research related to probability, stochastic processes and their applications.
    Keywords: acyclic digraph ; maximal flow ; minimal cut ; minimal arc cover ; bipartite digraph ; decision-making ; expert assessments ; pairwise comparisons ; risk ; smart expansive system ; uncertainty ; vector compression method ; non-homogeneous Markov systems ; asymptotic behavior ; rate of convergence ; noisy threshold group testing ; defective samples ; number of tests ; bounds ; COVID-19 ; cyber-attack detection ; deep machine learning ; smart power grid ; data processing ; unavailability ; imperfect repair ; failure-based replacement ; renewal theory ; optimization ; batch service ; roots ; discrete-time queue ; discrete renewal theory ; finite buffer capacity ; large outliers ; arrays of observations ; complex systems ; digraphs ; queues ; bulk service ; multi-server ; Markov chain ; quorum ; k-out-of-n system ; dependent failures ; order statistics ; reliability characteristics ; sensitivity analysis ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins. This largest amino acid serves as the precursor for the important endogenous indoleamines serotonin, N-acetylserotonin, and melatonin that act as neurotransmitters, neuromodulators, and neurohormones. Kynurenic acid is the most potent endogenous antiexitotoxic agent. Other highly relevant pathways of tryptophan are the reversible transamination to indole-3-pyruvate with formation related indolic acids that act as potent antioxidant agents. Tryptophan metabolites, such as melatonin, and structurally related agents, such as indole-3-propionic acid, act as potent catalytic antioxidants and bioenergetic agents that facilitate regeneration and protection against stress and aging. Several indole compounds act as uremic toxins since these agents can induce radical formation that is associated with enhanced oxidative stress and damage. The exploration of the effects of these protective and toxic tryptophan derived agents has revealed important molecular mechanisms and mediators of adaptation and aging. Research on tryptophan in nutrition and health can facilitate the development of new approaches to extend human health and life span. Amino acids are the building blocks of life that enable repair, as well as recycling and regeneration. Research on nutrients like amino acids, such as tryptophan and its metabolites, as well as peptides and proteins, or extracts containing this molecular metabolism modifiers can improve health. Research into the indololome is a new emerging and rapidly growing field of utmost relevance to science and society.
    Keywords: tryptophan ; kynurenine ; kynurenic acid ; FICZ ; AhR ; melanoma ; proliferation ; cell death ; aryl hydrocarbon receptor ; chronic kidney disease ; developmental origins of health and disease (DOHaD) ; hypertension ; indole ; melatonin ; serotonin ; uremic toxin ; virus ; immunity ; codon ; depression ; chronic mild stress ; oxidative stress ; tryptophan catabolites pathway ; methylation ; expression ; escitalopram ; 5-hydroxytryptophan ; natural sources ; microbial production ; biosynthetic pathways ; physiological effects ; animal ; human ; kynurenine pathway ; MEL biosynthesis ; Saccharomyces cerevisiae ; yeast ; tryptophan extraction ; LC-MS/MS ; soybean ; skin ; atopic dermatitis ; psoriasis ; severe acute respiratory syndrome ; SARS-CoV-2 ; COVID-19 ; malignant melanoma ; urine ; autofluorescence ; transplantation ; ischemia-reperfusion ; tolerance ; rejection ; indoleamine-2,3-dioxygenase ; L-tryptophan ; amino acids ; MAC-T cell ; proteomics ; omics ; β-casein ; mTOR ; systemic inflammation ; dysbiosis ; gut ; microbiota ; obesity ; mice ; tyrosine ; cytokines ; behavior ; inflammation ; liver morphology ; color ; cell culture media ; LC-MS ; antioxidant ; cytotoxicity ; biomanufacturing ; 5-hydroxytryptamine ; secretion ; metabolism ; nitrofurantoin ; antibiotics ; human serum albumin ; molecular interactions ; FTIR ; fluorescence ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The present reprint contains all of the articles accepted and published in the Special Issue " Advances in Artificial Intelligence and Statistical Techniques with Applications to Health and Education" from the MDPI journal Mathematics. This Special Issue aims to develop more efficient and effective approaches to healthcare and education, leveraging the increasing availability of big data and advancements in artificial intelligence. By sharing new methods, applications, and case studies, this reprint is dedicated to the development of innovative solutions that improve healthcare and education for all. The topics addressed in this Special Issue cover a wide range of areas, including data mining, machine learning, learning analytics, prediction methods, pattern recognition, decision analysis, probabilistic reasoning, fuzzy systems, student or patient modelling, adaptive systems, collaborative systems, recommendation systems, experimental design, and empirical study cases. We hope that this reprint will enable the scientific community in both medicine and education to leverage the techniques from statistics and artificial intelligence to drive significant advances in their respective fields. These approaches hold promise for improving patient outcomes and enhancing the quality of education for students around the world.
    Keywords: Alzheimer’s disease ; dementia ; functional data analysis ; functional depth ; statistical data depth ; symmetry ; elemental information matrix ; gamma distribution ; poisson distribution ; D-optimization ; misspecification ; machine learning ; modeling ; programming ; text analysis ; remote rehabilitation ; recommender system ; stroke ; fuzzy logic ; telemedicine ; collaborative learning ; collaborative work ; genetic algorithms ; group formation ; personality traits ; computer-supported cooperative learning ; non-parametric statistics ; predictive methods ; supervised classification ; random methods ; after-school exercise ; academic performance ; structural relationship ; quantile regression ; instrumental variable quantile regression ; vitamin D ; decision making ; anthropometric parameters ; optimal experimental design ; bioimpedance ; impedance spectroscopy ; algorithm ; competency-based model ; didactic planning ; ontology ; natural language processing ; Bloom’s taxonomy ; retina ; fundus image ; retinal vasculature ; retinal disorders ; semantic segmentation ; learning behavior ; student performance prediction ; deep neural network (DNN) ; recurrent neural network (RNN) ; educational data mining (EDM) ; probabilistic graphical models ; bayesian networks ; value-based potentials ; approximate inference ; medical applications ; electrocardiogram signal ; discriminative convolutional sparse coding ; dictionary filter learning ; linear SVM ; student dropout ; Feature Selection ; Artificial Neural Networks ; Support Vector Machines ; decision trees ; logistic regression ; ECG ; mental fatigue ; signal analysis ; classification ; OpenMarkov ; Bayesian Networks ; d-separation ; inference ; Learning Bayesian Networks ; continuous assessment ; Bayesian networks ; artificial neural networks ; influenza-like illness ; COVID-19 ; Arabic sentiment analysis ; disease classification ; Facebook ; Algerian dialect ; mobile computing ; dual tasking ; cognitive decline ; human motion tracking ; gait analysis ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Biosensors, especially non-invasive ones, are an area of extreme importance and fantastic advancements. As nanotechnology continually becomes more and more refined, its applications in a multitude of areas also grow. One area that has seen an explosion of innovations is healthcare. Such biosensors have allowed for the diagnosis, monitoring, and even treatment of a myriad of different disease states. This reprint highlights many of the past, current, and potential future advancements.
    Keywords: breathalyzer ; acetone ; ketogenic diet ; semi-conductor metal oxides ; tremor ; medical devices ; transcutaneous electrical nerve stimulation ; electrical stimulation systems ; wearable orthoses ; assistive feeding devices ; arteriovenous fistula ; SVM ; harmonic ratio ; vascular wall motion monitor ; SARS-CoV-2 ; COVID-19 ; point of care testing ; rapid diagnostics ; glucose sensor ; Cu2O nanomaterial ; electrochemical sensor ; non-enzymatic sensor ; chronic kidney disease ; salivary conductivity ; non-invasive ; portable ; biosensor ; n/a ; cellulose paper ; chitosan ; layer-by-layer ; self-assembly ; nanocomposite ; SERS spectroscopy ; iso-block postural identity ; OpenPose ; fusion deep learning ; electronic nose ; volatile organic compounds ; breath analysis ; smoking ; electromyography ; facial pain ; temporomandibular joint disorders ; jaw muscles ; diagnosis ; blood pressure (BP) ; Squeeze U-net ; photoplethysmogram (PPG) ; mHealth ; real time ; deep learning ; bioinstrumentation ; dual-channel ; glucose ; near-infrared ; NIR technology ; sensors ; optical spectroscopy ; photoacoustic spectroscopy ; electromagnetic sensing ; nanomaterials ; diabetes management ; biosensors ; biomaterials ; oral diagnostics ; pediatric population ; salivary diagnostics ; salivary biomarkers ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-29
    Description: The global financial crisis plunged the global economy into a great recession. Many central banks responded with unconventional monetary policies such as quantitative easing, negative policy rates, and forward guidance to calm down financial markets. The COVID-19 pandemic led the global economy, financial markets, and central banks to face even more severe problems. Central banks set up further asset purchase programmes to complement existing unconventional monetary policy measures that have already been in place to help the economy to absorb the COVID-19 shock. The new crisis has increased the importance of preserving financial stability through the international cooperation of central banks around the globe. Managing the expectations of market participants plays a crucial role in the context of financial stability. Therefore, the aim of this Special Issue is to disseminate important empirical and theoretical research questions concerning the connection between monetary policy and international financial markets and to stimulate discussion among academics and policymakers. A special focus is devoted to emerging and developing economies. The Special Issue covers several different articles on a variety of topics from the fields of monetary policy and international financial markets. The contributions address research questions on exchange rates, cryptocurrencies, stock markets, the connection between money supply and inflation after the COVID-19 pandemic, the role of commodity price shocks for banking system stability in developing countries, global liquidity effects, the twin deficit, and the Taylor rule.
    Keywords: Taylor rule fundamentals ; exchange rate ; out-of-sample ; forecast ; random walk ; directional accuracy ; financial crisis ; twin deficit hypothesis ; budget balance ; current account balance ; MENA region ; oil countries ; non-oil countries ; PVAR modeling ; financial-crisis ; South-East Asia ; event driven ; fund performance ; efficient market hypothesis ; adaptive market hypothesis ; behavioral finance ; market conditions ; Markov switching model ; threshold VAR ; global inflation ; inflation ; financial global ; finance liquidity ; commodity ; BRVM ; WAEMU ; regional stock exchange ; economic growth ; developing countries ; currency ; export ; stock returns ; triple regime-switching model ; Vietnam ; TASI ; unit root ; granger causality ; sectoral indices ; Sharia investment ; Jakarta Islamic Index (JKII) price ; loss risk ; geometric Brownian motion ; Value at Risk ; exchange ; exchange theory ; money ; money theory ; power ; financial inclusion ; commercial banks ; financial services ; profitability ; financial leverage ; Jordan ; cryptocurrency ; blockchain ; survival function ; risk ; weight ; hazard ratio ; commodity price shocks ; banking sector stability ; panel data ; Africa ; time series ; vector autoregressiion ; pandemic ; COVID-19 ; unemployment rate ; thema EDItEUR::K Economics, Finance, Business and Management
    Language: English
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  • 144
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Psychiatric disorders in children and adolescents are relevant both in terms of their prevalence (they are roughly estimated to affect about 20% of school-aged children and adolescents) and of their impact on the quality of life of the child/adolescent and their family, but also on the society as a whole. Disorders affecting children and adolescents are increasingly seen as having highly specific features, and, therefore, require an equally specific approach despite the coexisting need to integrate contributions from other professions (e.g., pediatricians, psychiatrists, psychologists, and therapists of different sorts). However, the available data are still insufficient, especially for treatment options and too often therapeutic choices are still made based on studies conducted in adults. Even more important, the existence itself of some disorders is questioned especially outside the scientific field (e.g., ADHD). This Special Issue provided cutting edge data on different aspects of child and adolescent psychiatry, including etiopatogenesis, clinical characteristics and diagnosis, medical and neurological comorbidities (and psychiatric comorbidities of medical and neurological disorders), impact on patients/families/society (including school and other social groups), prognosis, and treatment options of the different disorders.
    Keywords: social withdrawal ; alexithymia ; adolescence ; psychological disorders ; anxiety ; depression ; social problems ; videogames ; internet gaming disorder ; child behavior checklist ; post traumatic stress disorder ; refugee ; screening ; COVID-19 ; dyslexia ; reading skills ; learning disability ; attention deficit disorder with hyperactivity ; child ; adolescent ; mental health ; chronic disease ; register ; clinical protocol ; trans adolescents ; psychological distress ; internalizing problems ; YSR-R/CBCL-R ; parental congruence ; peer relations ; gender minority stress ; earthquake ; trauma ; PTSD ; parental psychopathology ; internalizing disorders ; youths ; children ; adolescents ; children and adolescents ; clinical practice ; early intervention ; interpersonal violence ; sexual abuse ; grandiose-manipulative ; callous-unemotional ; daring-impulsive ; psychopathy ; early adolescent ; conduct problems ; hyperactivity ; pediatric conditions ; psychiatric genetics ; anger ; self-regulation ; aneuploidy ; autosomal trisomy ; vocal stereotypies ; autism spectrum disorder ; automatic reinforcement ; stimulus control ; changing criterion design ; mental imagery ; social pain ; child and adolescent psychiatry ; inpatient ; day-clinic ; outcome quality ; treatment satisfaction ; quality of life ; Autism Spectrum Disorder ; social problem-solving skills ; interpersonal skills ; treatment ; assessment ; generalization ; n/a ; Child and Adolescent Mindfulness Measure (CAMM) ; reliability ; validity ; cutoff ; primary school students ; Chinese ; congenital heart disease ; health-related quality of life ; questionnaire ; anorexia nervosa ; family functioning ; Lausanne Trilogue Play ; restrictive eating disorders ; psychosocial difficulties ; daily performance ; play performance ; activities of daily living ; occupational therapy ; participation ; school-aged ; typically developing ; lockdown ; mood disorders ; chronic illness ; pandemic ; childhood ; positivity ; intolerance of uncertainty ; psychopathological symptoms ; psychological adjustment ; longitudinal study ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
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  • 145
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: The Special Issue "Focus on Antibiotics - New Challenges and Steps Forward in Discovery and Development" addresses the latest efforts towards discovering new antibiotics. The articles in this Special Issue cover various topics concerning antibacterial drugs. They provide valuable insights into the challenges and opportunities facing the field of antibiotic research and offer innovative solutions to tackle the growing problem of antibiotic resistance. The content of this Special Issue addresses antibacterial quinolones of the latest generation, new tetracyclines (such as glycylcyclines, aminomethylcyclines, and fluorocyclines), metal complexes (Ru (II/III) frameworks and Co(III) complexes with diamine chelate ligands), various nanoparticles (gold, silver and titanium dioxide nanoparticles), bioactive compounds produced by Mixobacterials species, anti-mycobacterial compounds acting as phosphopantetheinyl transferase inhibitors. The research in this Special Issue will contribute to pharmaceutics and ultimately contribute to developing new and effective antibiotics. We are grateful to the authors for their contributions and hope this Special Issue will stimulate further research and discussion on antibiotics. We also thank the reviewers for their time and expertise, and the editorial team for supporting this Special Issue. Finally, we hope this Special Issue will serve as a valuable resource for researchers, clinicians, and policymakers working towards a future where antibiotics remain vital in our fight against infectious diseases.
    Keywords: ruthenium ; antimicrobial ; antibacterial ; antiviral ; antiparasitic ; COVID-19 ; Co(III) coordination complexes ; antibacterial activity ; microbroth dilution method ; minimum inhibitory concentration ; minimum bactericidal concentration ; synergy assay ; serial passages assay ; DNA interactions ; PPTase ; NRPS ; indigoidine ; PptT ; antibiotic screening ; antibiotics ; bioactive compounds ; medication ; Myxobacteria ; human diseases ; fluoroquinolones ; quinolones ; structure-activity relationship ; DNA gyrase ; topoisomerase IV ; antibiotic resistance ; antimicrobial resistance ; Lepidium sativum L. ; silver nanoparticles ; biomaterials ; antimicrobial activity ; synergism ; green synthesis ; surgical site infection ; wound dressing ; oral bacteria ; Rothia mucilaginosa ; TiO2NPs ; biofilm inhibition ; Arthrobacter bangladeshi MAHUQ-56T ; AgNPs ; S. typhimurium ; Y. enterocolitica ; antimicrobial peptides ; synergistic effect ; CRAB ; antibacterial resistance ; ceftriaxone ; gold nanoparticles ; MIC50 ; tetracyclines ; mechanism ; resistance ; fluorocycline ; aminomethylcycline ; glycylcycline ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 146
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The clinical spectrum of systemic lupus erythematosus (SLE) is highly heterogeneous, ranging from mild disease, which can be limited to skin and joint involvement, to life-threatening conditions with renal impairment, severe cytopenias, central nervous system disease, and thromboembolic events. Apart from the host genetics, several environmental factors, such as sunlight, infections, drugs, and probably hormonal factors, can trigger the onset of symptoms related to SLE. Despite significant advances in our understanding of the pathophysiology and optimization of medical care, patients with SLE still have significant rates of premature mortality and many patients experience severe disease with increased risk of sustaining organ damage and having a reduced health-related quality of life. The development of effective drugs that can induce remission or low disease activity, the unanimous use of definitions of remission and low or high disease activity, flare, and response to therapy, the identification of non-invasive biomarkers of disease activity and long-term outcomes, and the implementation of SLE patients’ perspectives as an integral part of the clinical assessment constitute only a few of the many unmet needs in the field of SLE.
    Keywords: systemic lupus erythematosus ; quality of life ; cross-sectional studies ; surveys and questionnaires ; rheumatoid arthritis ; fatigue ; pain ; psychosocial ; disease activity ; health-related quality of life ; patient-reported outcomes ; clinical follow-up ; outcome measures ; abnormal liver function tests ; autoimmune liver diseases ; autoimmune hepatitis ; hepatic involvement ; liver biopsy ; primary biliary cholangitis ; COVID-19 ; hydroxychloroquine ; glucocorticoids ; epidemiology ; Systemic Lupus Erythematosus ; outcome ; mortality ; survival ; end-stage renal disease ; cancer ; cardiovascular disease ; infections ; neoplasm ; hospital admissions ; medication adherence ; compliance ; patient perspective ; qualitative research ; classification ; cluster analysis ; laboratory ; linear discriminant analysis ; genetics ; chronic damage ; polymorphisms ; TNFSF4 ; MIR1279 ; Ki/SL ; proteasome ; autoantibodies ; lupus ; SLE ; Sjögren syndrome ; flare ; damage ; long disease duration ; trajectories ; remission ; low disease activity ; comorbidities ; mood disorders ; low-disease activity ; patient outcome ; Afro-Caribbean ; systemic lupus ; lupus nephritis ; long-term prognosis ; dehydroepiandrosterone ; SLEDAI-2K ; n/a ; bic Book Industry Communication::M Medicine
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  • 147
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-08-08
    Description: The present reprint contains the 11 articles published in the Special Issue “Advances in Delay Differential Equations” of the MDPI journal Mathematics. The papers cover a wide range of topics connected to the theory of differential equations with delay. These topics include, among others, the construction of solutions, analytical and numerical methods for; dynamical properties of; and applications of DDE to the mathematical modeling of various phenomena and processes in physics, biology, ecology, and medicine. It is hoped that the reprint will be interesting and useful for those working in the area of differential equations with delays and nonlinear dynamics, as well as for those with the proper mathematical background who are willing to become familiar with recent advances in mathematical modelling, which have now entered almost all areas of science.
    Keywords: stochastic processes ; stochastic differential equation ; coupled system ; nonlocal stochastic integral conditions ; Ulam stability ; delay integro-differential equation ; Gronwall–Bellman inequality ; semi-Hyers–Ulam–Rassias stability ; delay differential equations ; Laplace transform ; epidemic model ; disease duration ; time delay ; COVID-19 ; logistic equation ; delay ; quasinormal form ; asymptotic behavior ; dynamics ; carbon absorption-emission model ; multiple time scales method ; normal form ; Hopf bifurcation ; asymptotics ; large parameter ; relaxation oscillations ; periodic solutions ; HIV ; AIDS ; PrEP ; differential–difference system ; discrete delay ; France ; neutral differential equations ; higher-order ; oscillation theory ; monotonic properties ; noncanonical case ; stability ; Andronov–Hopf bifurcation ; normal forms ; Kuramoto model ; synchronization ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science
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  • 148
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as a high-affinity ligand for the transcription factor VDR, i.e., it has direct effects on gene regulation. The key physiological functions of vitamin D are the regulation of calcium homeostasis, which is essential for bone mineralization, and the modulation of the immune system by stimulating innate immunity and preventing overreactions of adaptive immunity. This reprint presents recent developments and the latest research in the fascinating broad range of today’s vitamin D biology, from evolution to systems biology.
    Keywords: vitamin D ; VDR ; target genes ; chromatin ; epigenome ; transcriptome ; vitamin D signaling ; 25-hydroxyvitamin D ; 1,25-(OH)2D3 ; antitumor action ; breast cancer ; case-control studies ; colorectal cancer ; cohort studies ; ecological studies ; epidemiological studies ; randomized controlled trials ; UVB ; vitamin D receptor ; 3D structure ; structural analysis ; molecular recognition ; protein–ligand interactions ; coregulators ; acute myeloid leukemia ; blast ; 1,25-dihydroxyvitamin D ; analogs ; all-trans-retinoic acid ; differentiation ; immunomodulation ; evolution ; energy metabolism ; immune system ; calcium homeostasis ; migration of Homo sapiens ; influenza ; SARS-CoV-2 ; lung ; inflammation ; infantile hypercalcemia type 1 ; idiopathic infantile hypercalcemia ; CYP24A1 ; 25-hydroxyvitamin D 24-hydroxylase ; hypercalcemia ; 24,25-dihydroxyvitamin D3 ; fracture repair ; diet ; transcellular ; absorption ; diffusion ; intestine ; homeostasis ; parathyroid hormone ; gestational diabetes ; preeclampsia ; preterm birth ; ovarian cancer ; vitamin D analogs ; vitamin D deficiency ; single high dose ; vitamin D3 supplementation ; proinflammatory cytokines ; IL6 ; IL8 ; TNF ; 25(OH)D3 ; brain ; development ; neuroprotection ; disease mechanisms ; genetic risk ; heritability ; personalized supplementation ; genome-wide association study ; Mendelian randomization ; lumisterol ; anti-inflammatory ; ACE2 ; Mpro ; RdRp ; month of birth ; muscle ; pregnancy ; older adults ; metabolites ; hybrids and VDR nonsecosteroidal ligands ; nongenomic response ; PDIA3 ; ultraviolet radiation ; megalin ; mitochondria ; vitamin D metabolism ; fibroblast growth factor-23 ; klotho ; 1α-hydroxylase ; RAAS ; systems biology ; cell differentiation ; prostate cancer ; n/a ; bone ; osteoblasts ; differentiation and mineralization ; McCollum ; sunlight ; rickets ; food fortification ; vitamin D2 ; vitamin D3 ; COVID-19 ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 149
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-29
    Description: This reprint comprises 17 papers published in the Special Issue entitled “The Impact of COVID-19 on Financial Markets and the Real Economy”, centered on socioeconomic models affected by the pandemic (Vasin, 2022); the COVID-19 impact on various sectors or the economy as a whole, for instance in Canada (Singh et al., 2022), China (Habibi et al., 2022), Slovakia (Svabova et al., 2022), the United States (Rodousakis & Soklis, 2022) or Vietnam (Huynh et al., 2021; Nguyen et al., 2022); the benefits of teleworking on the continuity of operations across various sectors (Santos et al., 2022); research of the tourism and recreational possibilities of Russia and Kazakhstan’s cross-border regions and the threats these areas faced during the pandemic (Tanina et al., 2022), the impact of the new coronavirus infection on the Russian labor market (Rodionov et al., 2022); the factors driving young Vietnamese people’s intention to use financial technology in the context of the COVID-19 outbreak (Khuong et al., 2022) or those influencing access to credit for informal labor sector (Vu and Ho, 2022); predicting and analyzing Jordanian insurance firms’ performance (Altarawneh et al., 2022) or developing an early warning system for solvency risk in the banking industry (Hidayat et al., 2022) during the COVID-19 pandemic; the impact of the pandemic on European stock markets (Keliuotyte-Staniuleniene and Kviklis, 2022); the drivers of cross-border mergers and acquisitions during the pandemic (Lee et al., 2021); examining the financial and fiscal variables of Ecuadorian economic groups (Tulcanaza-Prieto and Morocho-Cayamcela, 2021).
    Keywords: COVID-19 ; pandemic ; tourism ; impact ; Vietnam ; entry mode ; mergers and acquisitions (M&As) ; sustainable development goal (SDG) index ; generalized linear model (GLM) ; economic groups ; family firms ; economic concentration ; economic power ; Latin America ; Ecuador ; coronavirus ; US economy ; multiplier effects ; tourism sector ; COVID-19 pandemic ; stock market ; stock index ; market volatility ; impulse response functions ; GARCH (1,1) model ; banking sector ; COVID-19 outbreak ; corporate insolvency ; simulation ; loan restructuring policy ; system dynamics ; early warning early action ; urban ; rural ; informal labor ; credit access ; quality of life ; Canada ; labour market ; industrial sectors ; financial time series forecasting ; stock markets ; forecasting methods ; technical analysis ; financial technology ; TAM model ; TRA model ; trade ; GDP ; economy ; labor market ; informational spread of coronavirus ; information environment ; monetary policy ; the COVID-19 pandemic ; policy responses ; DSGE models ; tourist and recreational potential ; border areas ; state support measures ; Leontief model ; Dirichlet distribution ; uncertainty analysis ; workforce ; disaster ; business environment ; pandemic impact ; transformation ; socioeconomic model ; Anglo-Saxon model ; Rhenish (German) model ; Scandinavian (Swedish) model ; Japanese model ; Chinese model ; Stringency Index ; World Pandemic Uncertainty Index ; n/a ; thema EDItEUR::K Economics, Finance, Business and Management
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  • 150
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-30
    Description: This Special Issue on Atopic Dermatitis focuses on novel insights into the pathogenesis of the immunological components of the disorder and the impaired epidermal barrier properties. It also explores the efficacy and safety of breakthrough therapies with topical agents and systemic therapies, such as monoclonals and JAK inhibitors. The aim of this Special Issue is also to present the expected future forefront of research and the treatment options that are expected to be available in the next few years.
    Keywords: atopic dermatitis ; dupilumab ; skin barrier ; transepidermal water loss ; n/a ; dexpanthenol ; topical corticosteroid ; emollient ; psoriasis ; mesenchymal stem cells ; biologics ; therapy ; regenerative medicine ; topical treatment ; JAK inhibitors ; PDE-4 inhibitors ; information campaign ; early diagnosis ; comorbidities ; patterns ; network analysis ; cancer ; real-world study ; biological therapy ; human epidermis ; immunofluorescence ; transmission electron microscopy ; keratinocytes ; interleukins ; toll-like receptors ; human beta-defensin 2 ; involucrin ; filaggrin ; claudin-1 ; exposome ; age ; skin of color ; COVID-19 ; war ; intrinsic atopic dermatitis ; atopic ; child ; dermatitis ; family ; quality of life ; narrow-band UVB phototherapy ; ultraviolet A1 phototherapy
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  • 151
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: This Special Issue welcomes research papers on new approaches that have been applied or are under development to improve preparedness and emergency response. We especially encourage the submission of inter-disciplinary and crosscutting research. We also encourage the submission of manuscripts that focus on various types of disasters, disaster and emergency research, and on policy or management solutions at multiple scales.
    Keywords: alcohol ; ethanol ; pedestrians ; traffic accidents ; flood ; disasters ; emergency preparedness ; hospital preparedness ; Saudi Arabia ; first aid ; education ; basic life support ; cardiopulmonary resuscitation ; feedback device ; simulation ; quality ; skill retention ; motivation ; chest recoil ; mannequin ; contact tracing ; ethics ; pandemic ; psychology ; public education ; public health ; alternative care facilities ; flexible surge capacity ; major incidents and disasters ; surge capacity ; information and communication technology ; smart disaster management system ; Internet of Things ; disaster ; flood early warning ; flood response ; community volunteerism ; disaster volunteer group ; resilience ; governance and planning ; disaster management ; sustainability ; security ; safety ; crisis management ; risk management ; emergencies ; health emergency ; management ; disaster legislation ; preparedness ; COVID-19 ; stress ; stressors ; cortisol ; medical simulation ; low-fidelity simulation ; high-fidelity simulation ; stress appraisal questionnaire ; KOS-B ; nursing ; machine learning ; health geomatics ; geographic information system ; emergency medical services ; spatial filtering ; geo-AI ; resources management ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine
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  • 152
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This reprint presents recent advances in understanding the molecular processes that take place in adipose tissue inflammation in the context of obesity. It discusses the impact of adipose tissue inflammation on systemic metabolic alterations associated with excess adiposity, as well as its repercussion in several pathological conditions that may help to understand obesity-associated metabolic derangements.
    Keywords: adipose tissue ; fatty acid-binding protein 4 ; proinflammatory adipokine ; insulin resistance ; gestational diabetes mellitus ; type 2 diabetes mellitus ; adiponectin ; body mass index ; colostrum ; leptin ; phagocytes ; obesity ; overweight ; oxidative stress ; adipose tissue inflammation ; pancreatic ductal adenocarcinoma ; BDNF ; Val66Met polymorphism ; adipogenesis ; arterial thrombosis ; physical exercise ; Il-6 ; Mcp-1 ; Tnf-α ; liver ; inflammation ; steatosis ; liver resection ; liver transplantation ; lipectomy ; type 2 diabetes ; bariatric surgery ; mast cells ; coagulopathy ; COVID-19 ; cytokine storm ; SARS-CoV-2 ; adipokines ; body fat distribution ; obesity pathophysiology ; hypoxia ; steroid receptor RNA activator 1/SRA1 ; TLRs ; IRFs ; type-2 diabetes ; n/a ; bic Book Industry Communication::M Medicine
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  • 153
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions.
    Keywords: COVID-19 ; drug repurposing ; topological data analysis ; persistent Betti function ; SARS-CoV-2 ; network-based pharmacology ; combination therapy ; nucleoside GS-441524 ; fluoxetine ; synergy ; antidepressant ; natural compounds ; QSAR ; molecular docking ; drug repositioning ; UK Biobank ; vaccine ; LC-2/ad cell line ; drug discovery ; docking ; MM-GBSA calculation ; molecular dynamics ; cytotoxicity assay ; GWAS ; multiple sclerosis ; oxidative stress ; repurposing ; ADME-Tox ; bioinformatics ; complex network analysis ; modularity clustering ; ATC code ; hidradenitis suppurativa ; acne inversa ; transcriptome ; proteome ; comorbid disorder ; biomarker ; signaling pathway ; druggable gene ; drug-repositioning ; MEK inhibitor ; MM/GBSA ; Glide docking ; MD simulation ; MM/PBSA ; single-cell RNA sequencing ; pulmonary fibrosis ; biological networks ; p38α MAPK ; allosteric inhibitors ; in silico screening ; computer-aided drug discovery ; network analysis ; psychiatric disorders ; medications ; psychiatry ; mental disorders ; toxoplasmosis ; Toxoplasma gondii ; in vitro screening ; drug targets ; drug-disease interaction ; target-disease interaction ; DPP4 inhibitors ; lipid rafts ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries
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  • 154
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This reprint presents information to update the state-of-the-art knowledge on young, professional or recreational, male and female athletes. Moreover, it addresses current gaps in the literature on issues that have an impact on athletes (e.g., Crohn’s disease, Olympic weightlifting, and velocity speed loss). Importantly, this reprint contributes to knowledge on how to improve load monitoring (of training and competition) and health care for athletes through direct or indirect research.
    Keywords: football ; male ; training ; youth ; RPE ; GPS ; running ; high-speed running ; sprint ; performance ; load monitoring ; match load ; player load ; long-term ; talent identification ; team sport ; multivariate analysis ; electromyography ; lower trapezius ; muscle strength ; shoulder kinematics ; sports injuries ; psychological factors ; Bayesian network ; sport metabolomics ; oxidative stress ; hormone signalling ; adiponectin ; basketball ; n/a ; correlation ; external intensity ; inertial device ; internal intensity ; perceived exertion ; SIATE ; agility ; soccer ; flexibility ; predictors ; outcome ; strength ; power ; reactive strength ; players ; plyometric training ; resistance training ; external load ; contextual variables ; amateur ; home match ; away match ; combat sports ; elite athletes ; rapid weight loss ; extreme weight loss ; weight management ; female ; Hooper Index ; internal load ; load ; match ; training load ; inflammation ; bowel ; malnutrition ; physical activity ; high-intensity interval training ; sport ; mental load ; Stroop ; triathlon ; sports medicine ; sports physiology ; female athlete ; VO2 max ; ultra-endurance ; bone mass density ; bone remodelling markers ; bone formation ; bone resorption ; athlete ; exercise ; injury ; aquatic training ; bicycling training ; meniscal allograft transplantation ; rehabilitation ; dynamic balance ; range of motion ; external training load ; technology ; wearable inertial measurement units ; heart rate ; monitoring ; sports technology ; load quantification ; competition phases ; exercise monitoring ; athletic performance ; reproducibility ; coping with stress ; SARS-CoV-2 ; COVID-19 ; cross-cultural research ; blood flow restriction ; body composition ; low-intensity aerobic training ; recreational runner ; physical fitness ; vascular responses ; isometric ; jump ; stability ; static balance ; Clean and Jerk ; Olympic exercises ; Power Clean ; Snatch ; Squat ; weightlifting derivatives ; physical exercise ; saliva ; metabolomics ; proteomics ; sex ; hearing-impaired ; skill ; inspiratory muscle training ; center of pressure ; soccer players ; velocity–based training ; one–repetition maximum ; maximum strength ; training efficiency ; ports physiology ; women ; maximal aerobic speed ; athletics ; sprint/power athletes ; endurance athletes ; VDR ; rs2228570 polymorphism ; personality trials ; Big Five ; resilience ; athletes ; car drivers ; mindfulness ; awareness ; psychosocial variables ; fast day ; adaptation ; lifestyle ; men ; mental health ; interlimb ; symmetry ; injury risk ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 155
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Energy transformation significantly redefines the business models of enterprises in the energy sector, putting difficult decisions before them in terms of both strategy and operationalization. This shift aligns with climate protection policies, Industry 4.0 principles, and advanced technologies like artificial intelligence, blockchain, and IoT. The technological revolution is set to significantly alter lifestyles and business operations in energy production, supply, and distribution. This revolution demands that managers equip their companies and staff for upcoming challenges, emphasizing customer relations, networking, eco-development, and energy efficiency. In addition, companies from the energy sector are particularly susceptible to macroeconomic and environmental factors, such as government regulations, fluctuations in demand, price pressure on commodity exchanges, and measures to prevent global warming and engage in the creation of renewable energy. Furthermore, the situation related to the SARS-CoV-2 pandemic has forced many companies to rethink their actions. However, some recorded a significant slowdown in technology implementation and research and development. We do not know whether the long-term effect will influence the energy paradigm. This work aims to create new theoretical and empirical works on changes to energy sector management, including new business models and the use of Industry 4.0 technology, and their impact on organizations, digitization, companies’ energy self-sufficiency, and investments supporting the so-called green economy.
    Keywords: pro-environmental self-identity ; green energy purchase intention ; photovoltaic panels ; social value ; emotional value ; energy sector ; pro-innovative HR practices ; psychological contract ; job commitment ; job satisfaction ; management ; schools of management ; planning approach ; positional school ; resource-based approach to strategy ; the innovative and entrepreneurial approach ; network organization ; energetics ; regulated sector ; strategy ; energy producers ; management model ; rural electrification ; sustainability ; governance ; technology ; business model ; non-dominated sorting genetic algorithm-II (NSGA-II) ; multi-objective particle swarm optimization (MOPSO) ; cross-docking ; multi-energy concern ; Agenda 2030 ; the energy sector in Poland ; capital concentration ; mergers and acquisitions ; FSRU ; LNG ; appraisal modeling ; modeling energy project appraisal ; economic assessment ; project incentives ; energy project accounting ; greenfield project planning ; project due-diligence ; restructuring ; energy policy ; hard coal mining ; energy transition ; agglomeration ; cluster ; specialization ; cooperation ; innovation ; PLS-SEM ; energy ; oil price shocks ; hydrocarbon markets ; transmission channels ; asymmetries ; fuel ; fuel supplies ; COVID-19 ; coronavirus ; transport ; UE ; energy economics and management ; digitalisation ; drivers ; business models ; changes ; circular business model ; circular economy ; environmental awareness ; supply chain ; development ; waste ; controlling ; controlling tools ; energy and heating ; E&H ; integrated reporting ; non-financial reporting ; Warsaw Stock Exchange (WSE) ; energy industry ; petroleum industry ; crisis index ; bic Book Industry Communication::J Society & social sciences
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  • 156
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Satellite measurements of night-time lights are widely recognized as a valuable indicator of human activity on Earth. These measurements capture the amount of light emitted from Earth at night and provide significant insights into a range of fields, including urbanization processes, socio-economic dynamics, local and regional GDP, economic impacts of conflicts, effects of epidemics on economic activity, and the various impacts of natural and man-made disasters. This reprint includes 16 articles that were published in the Remote Sensing Special Issue “Remote Sensing of Night-Time Light” and that highlight novel research on the remote sensing of night-time lights. The reprint aims to stimulate progress in the remote sensing research domain related to the utilization of night-time lights in a wide range of multidisciplinary and interdisciplinary domains, including urban studies, ecology, economics, oceanography, sociology, epidemiology, and more.
    Keywords: VIIRS ; Day-night band (DNB) ; Nighttime lights ; COVID-19 ; Pandemic ; earth observation data ; nitrogen dioxide (NO2) ; night light imagery (VIIRS) ; mobility ; environmental impacts ; night-time lights ; pandemic ; protected areas ; wildlife tourism ; night-time light remote sensing ; ethnic minorities ; core ethnic minority areas ; development index ; toponym data ; VIIRS/DNB ; nighttime lights ; shipping ; spatial analysis ; anchorage area ; GDP ; nonlinearity ; panel data ; MAUP ; aggregation ; DNB ; flicker ; artificial lighting ; county urbanization ; population urbanization ; land urbanization ; economic urbanization ; comprehensive urbanization ; China ; Suomi NPP VIIRS ; recalibrated/reprocessed historical radiance data ; CNN/SI ; urban night light long-term time series ; urban growth ; aerosols ; night-time light data ; extraction of urban areas ; rank–size rule ; law of primate city ; DMSP-OLS ; data fusion ; urbanization processes ; insect decline ; artificial light at night ; nighttime light remote sensing ; road lighting quality measurements ; JL1-3B ; Nanjing ; CO2 emission ; integration of two nighttime light datasets ; spatial-temporal dynamics ; STIRPAT ; policy ; Tibetan plateau ; light pollution ; urbanization ; highway ; railway ; biodiversity ; landscape sustainability ; carbon emission ; energy conservation ; genetic algorithm ; nighttime light data ; urban agglomerations ; remote sensing ; snow extent ; nighttime ; moonlight ; thresholding ; land cover ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 157
    Publication Date: 2024-04-02
    Description: In spring 2020, the COVID-19 virus and subsequent lockdown demanded that university institutions across the globe undertake an emergency migration to online teaching. To secure the continuation of university teaching, Emergency Remote Teaching (Bozkurt and Ramesh, 2020)—prompt rethinking and adjustment among university teachers—had to be managed. On the one hand, this abrupt change is associated with a certain digital and pedagogical potential for change due to the necessary adaptation efforts. On the other hand, it also poses an extraordinary organisational and pedagogical challenge. From an empirical perspective, it is therefore crucial to ask how university teachers and universities are tackling the coronavirus situation against the backdrop of the goal to maintain high-quality teaching. Furthermore, the adjustment and well-being of students in the context of hybrid and distance learning situations must remain in focus. The aim of this Special Issue was to provide unique insights into organisational, pedagogical, and psychological challenges related to digital transition in Higher Education institutions in different countries resulting from university lockdowns during the COVID-19 pandemic. It also discusses digital and pedagogical potentials evolving through the adaptation efforts related to the situation of Emergency Remote Teaching at universities.
    Keywords: educational technology ; pandemic ; future ; social construction ; health sciences ; academic productivity ; COVID-19 ; higher education institution ; university teaching ; faculty ; self-efficacy ; technology-enhanced learning ; professional development ; institutional support ; Social Cognitive Theory ; medical science ; student motivation ; education ; undergraduate ; remote teaching ; higher education ; assessment ; teacher’s perceptions ; levels of satisfaction ; emergency remote education (ERE) ; online learning ; digitalization ; SWOT ; emergency remote teaching ; university teachers ; wellbeing ; agency ; digital literacy ; Emergency Remote Teaching ; pedagogical conceptions ; COVID-19 lockdown ; critical realism ; rural-based university ; unintended pedagogical consequences ; Bangladesh ; challenges ; digital pedagogies ; education in emergencies ; emergency remote teaching and learning ; higher education institutes ; online distance teaching and learning ; opportunities ; future directions ; teaching methodologies ; face-to-face teaching ; online teaching ; learning difficulties ; statistics teaching ; remote evaluation ; ERT ; self-efficacy in online teaching ; cross-country comparison ; technology acceptance and use ; SEM ; COVID ; e-learning ; n/a ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JN Education
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  • 158
    Publication Date: 2024-03-28
    Description: This Special Issue of Biomolecules, “Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday”, is a dedication to one of the discoverers of IDPs. This collection is a small token of the respect, admiration, and affection the contributors have for Prof. Vladimir (Volodya) Uversky. It is also a celebration of his illustrious career, and his accomplishments, and contributions to the IDP field that have inspired so many minds worldwide. This Special Issue presents the state of the art as it emerges from the contribution of the community of IDP researchers (IDPers), who have responded to the invitation to give credit to the pioneering work of Prof. Vladimir Uversky aimed at defining the class of disordered proteins and at promoting the attention of scientists toward the existence of “non-globular proteins”. The papers in this collection show the advancement of our knowledge through the application of an integrative structural approach and witnesses at the same time the interest of the IDPer community toward new concepts (i.e., liquid-liquid phase separation) and new methodological frontiers (i.e., the application of machine learning and artificial intelligence to disorder prediction and modelling).
    Keywords: charge clustering ; polyelectrolytes ; average shape of conformational ensembles ; charged-residue patterning ; hydrodynamic radius ; solvent-accessible surface area ; proline content ; conformational compactness ; ellipsoid model ; intrinsically disordered proteins (IDPs) ; intrinsically disordered protein regions (IDRs) ; LC–MS/MS ; IUPred analysis ; Ostrinia nubilalis ; cold hardiness ; intrinsic disorder ; intrinsically disordered proteins ; intrinsic disordered regions ; disorder scale ; disorder propensity ; amino acids ; amino acid bias ; predictive performance ; disorder prediction ; SARS-CoV-2 ; COVID-19 ; IDP ; RNA ; NMR ; pH ; liquid-liquid phase separation ; protein solubility ; protein disorder ; mutations ; bioinformatics ; kinetics ; fluorescence ; site-directed mutagenesis ; protein–protein interactions ; SH2 domains ; Crkl ; Paxillin ; Calvin-Benson-Bassham cycle ; conditionally disordered protein ; history of modern science ; metabolism regulation ; moonlighting protein ; protein-protein interaction ; biomolecular condensates ; machine learning ; predictor ; physical interactions ; phase separation ; liquid–liquid phase separation ; biomineralization ; calcium carbonate ; otoliths ; nucleation pathways ; nickel ; intrinsically disordered regions ; lung cancer ; nmr ; isothermal titration calorimetry ; circular dichroism ; light scattering ; Dss1 ; intrinsically disordered protein ; IDPs ; molecular dynamics ; sequence composition ; SAXS ; membrane-less organelles ; stress ; long foldable segments ; pyHCA ; soluble domains ; protein sequence ; conditional order ; hidden order ; dark proteomes ; intrinsically disordered domains ; coexistence line ; tumor suppressor p53 ; intramolecular interaction ; salt-dependent binding affinity ; counterion condensation theory ; DNA binding ; fluorescence anisotropy ; van’t Hoff ; protein purification ; affinity chromatography ; Tau ; androgen receptor (AF1) ; isoform ; large-scale analysis ; protein structure ; AlphaFold ; canonical protein ; alpha-synuclein ; membrane ; synaptic vesicle ; synapsin ; Parkinson’s ; Myc ; drug targets ; SLiM ; small-molecule inhibitors ; glutamate receptor ; discrete molecular dynamics ; single molecule fluorescence ; integrative structural biology ; unfolded ; unstructured ; flexible ; protein function ; polymer physics ; percolation ; entanglement ; topology ; polymer rheology ; D/E repeats ; K/R repeats ; molecular dynamics simulations ; hub proteins ; multivalency ; transcription factor ; linker length ; heterogeneity ; dimers ; duplexes ; coarse-grained simulation ; molecular mass ; LLPS stability ; FUS ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 159
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The development of mathematical models and their optimization are fundamental for the effective resolution of many problems in operational research. In recent years, increased insights into real-world problems have led to the development of new mathematical models and optimization algorithms, contributing to the development of a research area with increasing practical relevance. This Special Issue is dedicated to works at the interface of mathematical modeling, optimization, and operations research, with a special focus on their real-world applications. The interest of the scientific community was significant, with submissions from authors from different countries from five continents, including Australia, China, Egypt, India, Israel, Portugal, Russia, Saudi Arabia, and the United States of America. Ten papers were accepted for publication after thorough peer review by dedicated reviewers with expertise in the relevant fields. We are confident that the papers selected for this Special Issue will attract a significant audience in the scientific community and will further stimulate research involving the development of mathematical models and their optimization.
    Keywords: multi-time generalized Nash equilibrium problem ; projected dynamical system ; river basin pollution problem ; traffic network equilibrium problem ; variational inequality problem ; freight transportation ; heavy-haul railway ; combination scheme ; train timetable ; genetic algorithm ; trapezoidal type demand ; interval-valued inventory costs ; deterioration ; preservation technology ; QPSO algorithms ; mixed integer nonlinear programming ; piecewise linear approximation ; branch and bound ; pairwise comparison ; matrix approximation ; log-Chebyshev metric ; tropical optimization ; consumer preference ; hotel selection ; partial trade credit ; cash discount ; deteriorating items ; EOQ ; COVID-19 ; metaheuristics ; project selection ; portfolio management ; resource ; R&D ; roadmap ; program management ; scheduling ; unrelated parallel machines ; sequence-dependent tasks ; makespan ; statistical analysis ; global optimization ; unconstrained minimization ; numerical approximations of gradients ; meta-heuristics ; stochastic parameters ; conjugate gradient methods ; efficient algorithm ; performance profiles ; comparisons ; testing ; discrete optimization ; dragonfly algorithm ; optimization ; swarm intelligence algorithms ; traveling salesman problem ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science
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  • 160
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: Working life is in a major transition. Furthermore, environmental, societal, and economic problems challenge human activities. The need to develop reliance and sustainability also through higher education is evident. It has been anticipated that emphasis on entrepreneurship competencies will be even stronger in the future. In this book, Entrepreneurial Education Strengthening Resilience, Societal Change and Sustainability, we provide insights on how to develop entrepreneurial competencies within higher education and its existing networks. First, the book guides the reader to understand how political documents steer the implementation of global goals and what could be improved. Second, we present how pedagogical solutions and models can meaningfully support the development of entrepreneurial competencies in the field of higher education. We also show the complexity of this phenomenon, thus developing a deeper understanding of this educational issue. Third, we highlight the essence of developing teacher education in this context. Fourth, we stress that entrepreneurial competencies are also needed in the working life. Lastly, we present some interesting key points for developing entrepreneurial higher education from the entrepreneurial ecosystem point of view. The book consists of 13 articles from international scientific experts in this field. Our book provides new knowledge, ideas and opportunities for creating practices to enhance the development entrepreneurial, sustainable and resilient societies. The book is targeted to researchers, policy-makers, higher education providers, stakeholders, educators and trainers.
    Keywords: universities’ partnerships ; entrepreneurial attitude ; perceived desirability ; perceived feasibility ; entrepreneurial passion ; sustainable entrepreneurship intentions ; human capital ; labor market ; training ; talent management ; corporate governance ; entrepreneurial mindset ; career adaptability ; intolerance of uncertainty ; prospective anxiety ; inhibitory anxiety ; college student ; team learning ; entrepreneurship ; entrepreneurship education ; entrepreneurial competencies ; innovation ; entrepreneurial competences ; learning community ; EntreComp ; EU policy ; entrepreneurial education ; sustainability education ; social change ; creativity ; action competence ; faculty community of practice ; resilience ; COVID-19 ; sustainability-oriented entrepreneurship education ; teaching cases ; university-based ecosystem ; key elements ; development process ; sustainable construction strategy ; entrepreneurial education model ; entrepreneurial university ; graduate entrepreneurship ; progression model ; sustainability in entrepreneurial education modeling ; education for sustainable development ; key sustainability competencies ; transformative learning ; sustainability ; sustainable education ; teacher education ; curriculum ; Nordic education ; entrepreneurial intention ; Theory of Planned Behavior ; multigroup analysis ; Sustainable Development Goals ; social impact ; empowerment ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
    Language: English
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  • 161
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Personalized medicine is playing an important role in cancer prevention. To date, it is clear that many cancers are molecularly distinct subtypes, and different therapeutic approaches would be required for each. This Special Issue brings together original research and review articles on molecular oncology with attention to the early detection and prevention of cancer. It highlights new findings, methods, and technical advances in molecular cancer research. The main feature of this reprint was to provide an open-source sharing of significant works in the field of molecular oncology that can increase our understanding of cancer development. Topics include:Molecular methods to personalize cancer screening and detection;Molecular target therapies to prevent cancer development and metastases;Identification and new aspects of cellular signaling molecules and pathways for target discovery, drug design and personalized and gender medicine;Drug repurposing for cancer prevention;Molecular modeling studies.
    Keywords: colorectal cancer ; adenomas ; array comparative genomic hybridization ; long non-coding RNA ; MALAT1 ; COVID-19 ; SARS-CoV-2 ; ketogenic diet ; nutrition in pregnancy ; microbiota ; cancer ; carcinoma ; precision medicine ; health promotion ; metabolomics ; amino acid restriction ; glucose restriction ; mass spectrometry ; low carb ; 2-deoxy-D-glucose ; 2-DG ; methionine ; perfusion culture ; energy restriction ; caloric restriction ; target discovery ; epithelial–mesenchymal transition (EMT) ; RNA-binding protein 3 (RBMS3) ; carcinogenesis ; target therapy ; zinc fingers ; homeoboxes ; ZHX1 ; ZHX2 ; ZHX3 ; HCC ; miR-221 ; astrocyte elevated gene-1 ; angiogenesis ; cell proliferation ; regulatory genes ; α-catulin ; CTNNAL1 ; catenin ; invasion ; epithelial-mesenchymal transition ; EMT ; vascular mimicry ; statins ; repurposed drugs ; gynecological cancer ; endometrial cancer ; ovarian cancer ; cervical cancer ; NSCLC ; BPR0C261 ; radiosensitivity ; DNA damage ; microtubule inhibitor ; p53 ; PTEN ; acridine-triazole ; acridine-thiadiazole ; topoisomerase I ; anti-angiogenesis ; zebrafish ; neuroblastoma ; ATRX ; MYCN ; ClpPX protease ; ONC201 ; apoptosis ; mitochondria ; liquid biopsy ; lung cancer ; biomarkers ; dysgeusia ; dysosmia ; taste ; smell ; cancer treatment ; rapid review ; glycolysis ; cancer metabolism ; combination therapy ; Akt ; anti-inflammatory action ; COX-1 ; hydrazones ; non-small cell lung cancer ; thiosemicarbazides ; gastric cancer ; pepsinogen ; gastrin G17 ; Helicobacter pylori ; screening ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 162
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains original research and review chapters concerning the latest advancements in various topics related to pediatric fractures. Topics include fractures of the face, clavicle, shoulder, elbow, forearm, wrist, pelvis, femur, and tibia; special considerations focus on osteogenesis imperfecta patients; and consideration is also given to general pediatric fracture topics, such as the influence of the COVID-19 pandemic, mortality after pediatric trauma, the effects of NSAID and electronic cigarette use, and chapters on epidemiology and physical activity.
    Keywords: 3D ultrasonography ; wrist ; fractures ; pediatric ; artificial intelligence ; humerus fracture ; proximal humeral fracture ; children ; plate fixation ; ORIF ; tissue entrapment ; biceps ; COVID-19 ; pediatric trauma HUB ; outbreak ; ER admissions ; pediatric fractures ; pediatric injuries ; non-accidental trauma ; self-defense ; violence ; adolescent ; dexterity ; biomechanics ; shock index ; pediatric age-adjusted shock index ; trauma ; pediatric trauma ; mortality ; forearm malunion ; osteotomy ; patient-specific guides ; 3D ; NSAIDs ; ibuprofen ; fracture healing ; pediatrics ; evidence-based recommendations ; recurrent patellar dislocation ; knee injury ; medial patellofemoral ligament reconstruction ; supracondylar humerus fracture ; vascular injury ; brachial artery injuries ; bone fractures ; osteogenesis imperfecta ; clavicle ; fracture ; pseudarthrosis ; treatment ; diagnosis ; e-cigarette ; vaping ; adolescent health ; pediatric orthopedics ; surgery ; orthopedics ; supracondylar humerus ; night ; reduction ; after-hours ; brittle bone disease ; rehabilitation ; collagen ; injury prevention ; fracture risk ; global recommendations on physical activity for health ; SQUASH questionnaire ; multi-center ; adolescents ; pediatric orbital fracture ; orbital trapdoor fracture ; n/a ; titanium elastic nails ; tibial fracture ; elastic stable intramedullary nailing (ESIN) ; physeal ; physis ; long-bone fractures in children ; pediatric facial fractures ; etiology ; epidemiology ; Romania ; fat pad sign (FPS) ; elbow ; survey ; receiver operating characteristic (ROC) ; intraclass correlation coefficients (ICC) ; anterior fat pad sign (AFPS) ; posterior fat pad sign (PFPS) ; apophysial avulsion ; rectus femoris tendon ; sport ; pediatric radial neck fracture ; radial neck angulation ; elbow motion ; bic Book Industry Communication::M Medicine
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  • 163
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This Special Issue on CFS/ME collects 18 papers with an interdisciplinary view on the current demographic and epidemiological data and immunological characteristics of CFS/ME and examines the different pathogenic hypotheses, as well as giving information about the latest knowledge on diagnostic investigations, pharmacological, integrative, physical, cognitive-behavioral and psychological curative approaches.
    Keywords: chronic fatigue syndrome ; myalgic encephalomyelitis ; RCT ; measurement ; cardiopulmonary exercise test ; postexertional malaise ; fibromyalgia ; dual task ; MMSE ; MoCA ; TUG ; cognitive ; autonomic nervous system ; exercise ; mitofusin ; oxygen consumption ; PEM ; brain fog ; vascular stiffness ; autoimmunity ; immunology ; IgG replacement ; IgG deficiency ; biomarker ; ME/CFS ; COVID-19 ; diagnostic ; impact on society ; myalgic encephalomyelitis/chronic fatigue syndrome ; routine blood tests ; diagnostic criteria ; functional status ; creatinine ; creatine kinase ; CFS ; prevalence ; Korea and Japan ; meta-analysis ; EEG ; fast Fourier transform ; diagnosis ; ROC curve ; follow-up ; adolescence ; health ; wellbeing ; adrenergic receptors ; autoantibodies ; vasoregulation ; G-protein-coupled receptor ; exercise for well-being ; active exercise program ; flexibility ; static balance ; pain ; quality of life ; C1q ; complement system ; blood analytics ; symptoms ; cluster analysis ; autonomic function ; electrodermal activity ; electrocardiogram ; heart rate ; immunity ; dysbiosis ; hormone ; depression ; genetics ; miRNA ; therapy ; intestinal permeability ; metabolic endotoxemia ; LPS ; ozone ; oxygen–ozone therapy ; fatigue ; clinical trial ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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  • 164
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: This reprint covers the theory and fabrication of plasmonic nanostructures, patterned surfaces, and devices for lossy mode resonance (LMR), surface plasmon resonance (SPR), surface-enhanced fluorescence spectroscopy (SEFS), and surface-enhanced Raman scattering (SERS)-based biosensors. The chapters in this reprint cover a range of topics, including the interplay between SPR and lossy mode resonance, fabrication of LSPR substrates using high-throughput techniques, recent advances in various nanostructures, recent developments in the field of nanostructured Ag substrates, and innovative advances in biosensors based on DNA nanotechnology. These chapters provide a comprehensive overview of recent developments in plasmonic biosensors, making this reprint essential reading for researchers working in biosensors and plasmonics.
    Keywords: patterned sapphire substrate ; localized surface plasmon resonance ; oblique deposition ; nanoimprint lithography ; wafer-scale ; biosensors ; DNA nanotechnology ; DNAzyme ; plasmonic biosensor ; aptamer ; DNA origami ; flexible SERS substrates ; coronavirus ; ultrasensitive detection ; biomarker ; rice sample ; mercury ; immunochromatographic assay ; qualitatively ; strip ; silver ; plasmonics ; sensors ; surface-enhanced Raman spectroscopy ; surface-enhanced fluorescence ; surface-enhanced infrared spectroscopy ; optical fiber sensor ; surface plasmon resonance ; lossy mode resonance ; indium-tin oxide ; sensitivity ; detection accuracy ; biosensor ; smart MXene quantum dots ; biomedical ; tetrabromobisphenol A ; surface-enhanced Raman scattering ; hydrophobic interaction ; bi-metal chips ; synergistic coupling ; glancing angle deposition (GLAD) ; biomedical detection ; GLAD substrates ; GO-SELEX ; ITC ; colorimetric sensor ; pesticide ; biosensing ; SERS ; disease diagnosis ; biomolecules ; microorganisms ; COVID-19 ; biohazardous molecules ; cancer ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: English
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  • 165
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: Working life is in a major transition and environmental, societal, and economic problems challenge human activities. The need to develop reliance and sustainability also through higher education is evident. It has been anticipated that emphasis on entrepreneurship competencies will be even stronger in the future. In this reprint, we provide insights on how to develop entrepreneurial competencies within higher education and its existing networks. It guides the reader to understand how political documents steer the implementation of global goals and what could be improved. Second, we present how pedagogical solutions and models can meaningfully support the development of entrepreneurial competencies in the field of higher education. We show the complexity of this phenomenon, thus developing a deeper understanding of this educational issue. Third, we highlight the essence of developing teacher education in this context. Fourth, we stress that entrepreneurial competencies are also needed in the working life. We present some interesting key points for developing entrepreneurial higher education from the entrepreneurial ecosystem point of view. It consists of 13 articles from international scientific experts in this field and provides new knowledge, ideas and opportunities for creating practices to enhance the development entrepreneurial, sustainable and resilient societies. It is targeted to researchers, policy-makers, higher education providers, stakeholders, educators and trainers.
    Keywords: universities’ partnerships ; entrepreneurial attitude ; perceived desirability ; perceived feasibility ; entrepreneurial passion ; sustainable entrepreneurship intentions ; human capital ; labor market ; training ; talent management ; corporate governance ; entrepreneurial mindset ; career adaptability ; intolerance of uncertainty ; prospective anxiety ; inhibitory anxiety ; college student ; team learning ; entrepreneurship ; entrepreneurship education ; entrepreneurial competencies ; innovation ; entrepreneurial competences ; learning community ; EntreComp ; EU policy ; entrepreneurial education ; sustainability education ; social change ; creativity ; action competence ; faculty community of practice ; resilience ; COVID-19 ; sustainability-oriented entrepreneurship education ; teaching cases ; university-based ecosystem ; key elements ; development process ; sustainable construction strategy ; entrepreneurial education model ; entrepreneurial university ; graduate entrepreneurship ; progression model ; sustainability in entrepreneurial education modeling ; education for sustainable development ; key sustainability competencies ; transformative learning ; sustainability ; sustainable education ; teacher education ; curriculum ; Nordic education ; entrepreneurial intention ; Theory of Planned Behavior ; multigroup analysis ; Sustainable Development Goals ; social impact ; empowerment ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
    Language: English
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  • 166
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: Diabetes is a worldwide public health problem that can be explained by the classic model of the determinants of health. Thus, success in preventing diabetes mellitus and its associated complications not only depends on the individual but also on social and community networks as well as general socioeconomic, cultural, and environmental conditions. For that reason, we need to create conditions that ensure good health and social care for an entire population through the development and implementation of preventive strategies, promotion of healthy lifestyles, protection from diseases, and the design of targeted screening strategies. This aligns with the United Nations Sustainable Development goal number 3, good health and well-being, which includes the achievement of universal health coverage and access to quality essential healthcare services. In addition, this also has a direct link to goal number 10, which focuses on reducing inequalities within and among countries. Pathological Mechanisms in Diabetes is a compilation of high-quality scientific evidence aimed at unraveling the molecular mechanisms involved in the association between diabetes and comorbidities and at describing their clinical and therapeutic implications. The variety of updated topics included from different approaches shows the need for more efficient preventive activities to reduce the incidence of this disease and its related complications.
    Keywords: Diabetes Mellitus, Type 2 ; Diabetes Mellitus, Type 1 ; Diabetes, Gestational ; Pancreatic and Duodenal Homeobox 1 Protein ; MAFA Protein ; Incretins ; Glucagon-Like Peptide-1 Receptor ; Insulin Resistance ; Oxidative Stress ; Hydroxyl Radical ; 2-Tyrosine ; 3-Tyrosine ; IRS1 Protein ; Phosphorylation ; Placental Insulin Receptor ; Fetal Development ; Obesity ; Body Mass Index ; Leptin ; Ghrelin ; Life Style ; Diet ; Primary Health Care ; Inflammation ; B-Lymphocytes ; Hepacivirus ; Immunoglobulin Light Chains ; NF- kappa B ; Insulin-Secreting Cells ; Immunosuppression Therapy ; Diabetic Nephropathies ; Lipid Metabolism ; MORG1 protein, mouse ; Mitogen-Activated Protein Kinase 1 ; WDR83 Protein ; Xanthine Dehydrogenase ; Polyneuropathies ; Diabetic Retinopathy ; Fovea Centralis ; Tomography, Optical Coherence ; Macular Edema ; COVID-19 ; SARS-CoV-2 ; Epidemiology ; alpha-Macroglobulins ; Apolipoprotein A-I ; Haptoglobins ; Non-alcoholic Fatty Liver Disease ; Liver Cirrhosis ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine
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  • 167
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This Special Issue contains 25 articles about mental health considering various cross-cultural perspectives. The findings and insights obtained from these articles will help researchers, practitioners, educators, students, and the general public to better understand mental health from different perspectives. We hope that such insights will help build a more compassionate world, instead of a stigmatised one.
    Keywords: hospices ; terminal care ; character ; attitude toward death ; nurses ; emotional contagion ; depression ; online depression community ; social media ; text-mining ; generalized trust ; psychological distress ; sleep ; insomnia ; suicide ; COVID-19 ; mental health ; psychological impact ; pandemic ; epidemic ; primary care physicians ; coronavirus disease ; rural ; coronavirus disease 2019/COVID-19 ; Internet Gaming Disorder Scale 9—Short Form (IGDS9-SF) ; university students ; factorial structure/psychometric properties/structural validity/validation ; cultur*/collectivisti*/individualis* ; invariance ; gender ; game type ; education students ; mental health shame ; caregiver identity ; self-compassion ; nursing ; health personnel ; clinical competence ; sexuality ; intervention ; Czech university students ; mental health attitudes ; K-12 ; coronavirus anxiety ; coronavirus obsession ; psychosocial impact ; DNA methylation ; schizophrenia ; Illumina EPIC ; C-SSRS ; anxiety ; psychiatric department ; hospital ; Mexico ; Indonesian students ; mental wellbeing ; academic engagement ; vigour ; dedication ; academic motivation ; online students ; intrinsic motivation ; extrinsic motivation ; mixed-method ; therapeutic patient education programme ; mental healthcare ; patient partnership ; motor function ; physical activity ; psychiatric inpatients ; physical therapist ; visual narratives ; diabetes ; chronic illnesses ; Tumblr ; obsessive-compulsive disorder ; psychotic disorder ; comorbidity ; insight ; functioning ; children ; fear of peers and inferiority ; urban–rural distinction ; economic segmentation ; China ; self-criticism ; amotivation ; self-hate ; self-inadequacy ; traumatic brain injury ; religious practice ; coping strategies ; caregiver ; social and emotional learning (SEL) ; pre-post intervention study ; school ; mainland China ; psychological intervention ; behavioral intervention ; adolescent depression ; ART adherence ; individual therapy ; theory of change ; intervention development ; mindfulness ; stress ; students ; brief COPE ; factorial analysis ; reduced version ; Spanish-speaking populations ; Mini-COPE ; distress ; return to work ; fathers ; fatherhood ; transitions ; paternal ; perinatal ; identity ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 168
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: The majority of newborns do not need medical interventions to manage the neonatal transition after birth. However, every year millions of newborns worldwide require respiratory support immediately after birth, and another considerable number of newborns additionally require extensive resuscitation including chest compressions and drug administration. Despite a significant increase in knowledge and development of enhanced therapy strategies over the past few years, morbidity and mortality caused by failures in neonatal transition remain an important health issue. The purpose of this reprint is to support or introduce novel concepts and add information in the area of the “Stabilization and Resuscitation of Newborns”, aiming to improve neonatal care and, as the major objective, to enhance neuro-developmental outcomes.
    Keywords: newborn ; neonatal resuscitation ; chest compressions ; sustained inflation ; neonate ; fetal hemoglobin ; oxygen saturation monitoring ; pulse oximetry ; inhaled nitric oxide ; resuscitation ; prematurity ; persistent pulmonary hypertension of newborn ; pulmonary vascular resistance ; hypoxic pulmonary vasoconstriction ; ventricular fibrillation ; defibrillation ; perinatal asphyxia ; hypoxic–ischemic encephalopathy ; therapeutic hypothermia ; outcome ; hypocapnia ; hyperoxia ; mechanical ventilation ; cardiac output ; cerebral oxygenation ; term neonates ; neonatal transition ; epinephrine ; flush volume ; asphyxia ; cardiac arrest ; epinephrine concentrations ; intubation ; endotracheal tube ; ventilation ; acute respiratory failure ; desaturation ; neonatal intensive care unit ; neonates ; multisystem inflammatory syndrome in children (MIS-C) ; anti SARS-CoV-2 antibodies ; COVID-19 ; meconium aspiration ; oxygen saturation targets ; persistent pulmonary hypertension of the newborn ; ductus arteriosus ; pulmonary blood flow ; post-resuscitation ; lung ultrasound ; transition process ; respiratory distress syndrome ; VLBW neonate ; blood sampling ; blood transfusion ; iatrogenic blood loss ; infant ; premature ; term ; bio-impedance ; non-invasive cardiac output monitoring ; meconium-stained amniotic fluid (MSAF) ; meconium aspiration syndrome (MAS) ; cyclooxygenase-2 (COX-2) ; nitric oxide (NO) ; nitric oxide synthase (NOS) ; (secure method for) umbilical venous catheter (UVC) ; UVC securement technique ; neonatal emergency ; disposable umbilical clamp ; vascular access ; n/a ; thema EDItEUR::M Medicine and Nursing
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  • 169
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Success, injuries, future career opportunities of athletes, and the societal gains of participating in sports and organizing (mega) sports events are all related to individual risk-taking behavior. Although the sports economics and management literature has broadly addressed these issues, it is surprising that less attention has been paid to the implications of risk-taking on the organization of sports in general and, more particularly, on the design and behavior of sports organization members.
    Keywords: sports ; economics ; management ; risk-taking ; in ; professional ; (e.g., ; doping, ; injuries, ; post-career ; path) ; organizing ; (mega) ; events ; implications ; of ; on ; the ; organization ; risk ; treatment ; organizations ; taking ; after ; COVID-19 ; pandemic
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  • 170
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: A multidisciplinary approach that involves multiple sectors and stakeholders is essential for disaster risk reduction and adaptation to climate change. This Special Issue explores how interdisciplinary approaches could resolve a wide range of issues, including risk and damage assessment, behavior change, investment, and evidence-based policy formulation.
    Keywords: natural hazard-triggered technological (Natech) ; risk perception ; protective actions ; evacuation ; household survey ; Cilegon ; Indonesia ; agricultural drought vulnerability ; spatial heterogeneity ; entropy weight method ; contribution model ; China ; risk assessment ; high-temperature disaster ; kiwifruit ; climatic suitability zoning ; hazard ; vulnerability ; exposure ; disaster prevention and mitigation capacity ; extreme temperature indices ; abrupt ; prediction ; disaster risk ; Yangtze River Basin ; climate change ; adaptation ; method ; digital disaster reduction ; natural disasters ; agricultural production ; food aid ; official development assistance ; conflict ; poverty ; cereal production ; humanitarian aid ; financing mechanism ; flood protection ; investment cycle ; investment in DRR ; Japan ; long-term plan ; lost decades ; Sendai Framework for Disaster Risk Reduction ; multi-variate Probit model ; Poisson regression model ; agricultural productive services ; earthquake disaster ; earthquake fatalities ; rapid estimation ; earthquake relief ; disaster assessment ; earthquake emergency response ; numerical simulation ; empirical method ; Yangbi earthquake ; COVID-19 ; disaster science ; evidence-based policymaking ; ordinal logistic regression ; principal component analysis ; compound indicator ; single-person households ; indirect death ; long-term effects ; excess mortality ; surveillance system ; disaster risk reduction ; disaster risk perception ; the population at risk ; agent-based modeling ; coastal areas ; community-based adaptation ; nature-based solutions ; green infrastructure ; perception ; family ; community ; Jakarta ; disaster preparedness capability ; heavy rainstorm ; local government ; AHP ; evaluation index system ; n/a ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: Recently, microfluidic, nanofluidic and lab-on-a-chip devices have gained particular attention in biomedical applications. Due to their advantages, such as miniaturization, versatility, ease of use, cost-effectiveness, and the potential to replace animal models for drug development and testing, these devices hold tremendous potential to revolutionize the research of more effective treatments for several diseases that threaten human life. With integrated biosensors, these devices allow the development and design of micro- and nanoparticles to be studied in detail, modelling human physiology, investigating the molecular and cellular mechanisms underlying disease formation and progression, and gaining insights into the performance and long-term effects of responsive drug delivery nanocarriers. This Special Issue gathered research papers, and review articles focusing on novel microfluidic, nanofluidic and lab-on-a-chip devices for biomedical applications, addressing all steps related to fabrication, biosensor integration and development, characterization, numerical simulations and validation of the devices, optimization and, the translation of these devices from research labs to industry settings.
    Keywords: protein biomarker ; microarray ; microfluidic cassette ; multiplex measurement ; immunoassay ; point-of-care testing ; microfluidic device ; small intestine ; ex vivo ; histology ; embedded resin ; sectioning ; peptide biosensor ; lab-on-a-chip ; label-free detection ; peptide aptamers ; protein biomarkers ; microfluidic biochip ; troponin T ; computational simulations ; drug discovery ; organ-on-a-chip ; microfluidic devices ; preclinical models ; numerical simulations ; automation ; non-enzymatic ; DNA amplification ; L-DNA ; microfluidic ; fluorescence ; paper microfluidics ; sweat ; sensing ; hydrogels ; lactate ; osmotic pumping ; evaporation ; capillary ; wicking ; biochemical assay ; microfluidics ; cell trap ; RBC ; evolutionary algorithm ; generative design ; artificial intelligence ; organ-on-chip ; liver-on-chip ; liver disease ; multi-level microfluidic device ; live cell imaging ; long-term microscopy imaging ; focus drifting ; immersion oil viscosity ; bacterial population dynamics ; single-cell studies ; E. coli ; mother machine ; computational fluid dynamics ; cancer-on-chip ; xenograft ; colorectal cancer ; pharmacodynamics ; pharmacokinetics ; drug efficacy ; oxaliplatin ; microfabrication ; microphysiological system ; biophysical stimuli ; biochemical stimuli ; in vitro cell culture ; cortical neurons ; hippocampal neurons ; electrical stimulation ; Micro-Electrode Arrays ; engineered neuronal networks ; polydimethylsiloxane ; microchannels ; in vivo micro bioreactor ; additive manufacturing ; poly-(ethylene glycol)-diacrylate ; biocompatibility ; COVID-19 ; diagnosis ; image analysis ; PCR ; SARS-CoV-2 ; n/a ; thema EDItEUR::M Medicine and Nursing
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: The present reprint contains all of the articles accepted and published in the Special Issue "Probability and Stochastic Processes with Applications to Communications, Systems and Networks" from the MDPI Mathematics journal. This Special Issue is devoted to probability, statistics, stochastic processes and their different applications in system and network analysis. The Special Issue includes works related to the analysis and applications of different queuing models, which begin with general approaches in modeling queuing systems and networks; an analysis of probabilistic and statistical methods in telecommunication; an asymptotic analysis of queuing networks in the condition of a large load; general complex networks and their structures, e.g., topology and graph theory; mathematical methods and models in smart cities; exclusive statistical methods, such as statistical estimates in bio/ecology, medicine and neural networks; and studies that estimate parameters in complex technical systems, etc. We hope that the scientific results collected in this reprint will help foster future research related to probability, stochastic processes and their applications.
    Keywords: acyclic digraph ; maximal flow ; minimal cut ; minimal arc cover ; bipartite digraph ; decision-making ; expert assessments ; pairwise comparisons ; risk ; smart expansive system ; uncertainty ; vector compression method ; non-homogeneous Markov systems ; asymptotic behavior ; rate of convergence ; noisy threshold group testing ; defective samples ; number of tests ; bounds ; COVID-19 ; cyber-attack detection ; deep machine learning ; smart power grid ; data processing ; unavailability ; imperfect repair ; failure-based replacement ; renewal theory ; optimization ; batch service ; roots ; discrete-time queue ; discrete renewal theory ; finite buffer capacity ; large outliers ; arrays of observations ; complex systems ; digraphs ; queues ; bulk service ; multi-server ; Markov chain ; quorum ; k-out-of-n system ; dependent failures ; order statistics ; reliability characteristics ; sensitivity analysis ; n/a ; thema EDItEUR::M Medicine and Nursing
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: "Functional Nanomaterials for Healthcare" is a collection showcasing cutting-edge research in advanced nanomaterials for healthcare applications. As healthcare evolves through science and innovation, these articles provide the latest insights into nanomaterial applications. Researchers have tailored nanomaterials for improved diagnostics, medical imaging, precise drug delivery, tissue engineering, and groundbreaking theranostics. This compilation, written by experts, explores advanced nanomaterial synthesis, functionalization, characterization, and diverse medical uses. Dive into this significant contribution to the field, offering a comprehensive overview of the latest innovations in healthcare nanomaterials for researchers, students, and healthcare professionals.
    Keywords: mitochondrial targeting ; gold nanoparticles ; cancer chemotherapy ; drug delivery ; betulinic acid ; laminin receptor ; zinc oxide nanoparticles ; organic surface deposit ; cytotoxicity assay ; photocatalytic activity ; ROS generation ; toxicity mechanism ; MDA-MB-231 ; HT-29 ; ebselen ; cerium ; ERK1/2 ; STAT-6 ; IL-4 ; STAT-1 ; antimicrobial activity ; carbon nanotubes ; human SP-D ; cancer cells ; apoptosis ; immunotherapy ; Alhydrogel® ; silica nanoparticles ; Bet v 1 ; BM4 ; SiO2 ; allergen ; structural integrity ; alum ; nanoparticles ; antimicrobial resistance ; bacteria ; resistance mechanism ; hyaluronic acid ; adipic acid dihydrazide ; silver nanoparticles ; polymer molecular weight ; antimicrobial ; SARS-CoV-2 ; protein nanoparticles ; vaccines ; nanovaccine ; nanomedicine ; protein-based nanotechnology ; graphene oxide ; biopolymer blends ; biomineralization ; ectopic bone formation ; osteoinduction ; ex vivo analysis ; nanotechnology ; cosmetic ; chitosan ; essential oils ; preservative agents ; metal-organic framework ; cardiovascular diseases ; graphene ; G+ ; PLA ; Grafylon ; scaffold ; neuronal differentiation ; stem cells ; 3D printing ; regenerative medicine ; Curcumin ; Paclitaxel ; triple-negative breast cancer cell lines (4T1 and MDA MB 231) ; metastasis ; capsaicin ; human ; pruritogens ; desensitization ; itch ; polymers ; compartments ; biomedical ; mesoporous silica nanoparticles ; MSN ; porous materials ; functionalisation ; NMR ; HR-MAS NMR ; surface ; COVID-19 ; cationic surfactants ; virucidal activity ; quaternary ammonium compounds ; disinfectants ; nanoprophylaxis ; viral inhibition ; human papillomavirus ; HPV ; pseudovirus ; viral infection inhibition ; nanocomplex formation ; photodynamic therapy ; photosensitizer ; upconversion nanoparticles ; graphene quantum dots ; reactive oxygen species ; green synthesis ; carbon nanomaterials ; biomass ; sustainability ; nanomaterials ; machine learning ; antioxidant ; biopolymers ; therapeutic substances ; incorporation ; biocompatibility ; healthcare ; biomedical applications ; surface characterization ; quantum yield ; label-free detection ; zinc oxide nanostructure ; surface functionalization ; mesoporous polydopamine ; ferric ions ; doxorubicin (DOX) ; hyaluronic acid target modification ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
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  • 174
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: The huge prevalence of type 2 diabetes is a leading human and economic concern worldwide. The diagnosis code of type 2 diabetes includes multiple clinical phenotypes showing different degrees of obesity, fat distribution patterns, types of dyslipidemia, and characteristics of insulin resistance syndrome. In addition, subjects with type 2 diabetes could develop different clinical trajectories, with age being a critical factor in progression. The chronic complications of type 2 diabetes are a major cause of mortality and disability, and are ranked in the top places in western countries’ scores. The pathophysiological heterogeneity of type 2 diabetes is not captured by the current classifications and guidelines. The potential for diabetes progression and complications developing is different depending on the type 2 diabetes cluster, which is mostly regardless of the degree of glycemic control. However, the impact on quality and life expectancy with the current therapeutic approach is not always the same for every individual. Clinical research is the key to reducing the burden of diabetes. New basic, digital, and clinical approaches are obtaining useful knowledge and designing more individualized interventions to prevent, track, and treat diabetic complications. This Special Issue is a clear reflection of this methodological evolution.
    Keywords: dipeptidyl peptidase-4 inhibitor ; diabetes mellitus ; diabetic retinopathy ; progression ; machine learning ; diabetic sensorimotor polyneuropathy ; random forest ; prediction ; electrophysiology ; COVID-19 ; hyperglycemia ; glycemic control ; blood glucose monitoring ; telemedicine ; fibrosis ; NAFLD ; diabetes ; screening ; primary care ; secondary care ; glucose variability ; end-stage kidney disease ; Korean National Health Insurance Corporation ; microvascular complications ; cardiac autonomic neuropathy ; diabetic peripheral neuropathy ; diabetic nephropathy ; patient profiles ; non-alcoholic fatty liver disease ; non-alcoholic steatohepatitis ; NASH ; type 2 diabetes ; cardiovascular disease ; cardiovascular complications ; CVD ; complex intervention ; behaviour change intervention ; co-design ; continuity of care ; developing country ; Ethiopia ; patient participation ; patient transfer ; stroke outcome ; skin autofluorescence ; advanced glycation end products ; poststroke complications ; obesity and diabetes mellitus type 2 ; research ; hospitalization ; risk factors ; cardiovascular diseases ; type 2 ; gender ; type 2 diabetes mellitus ; bone fragility ; fracture risk ; bone structure ; bone quality ; cardiac fibrosis ; pulse wave velocity ; liraglutide ; body weight ; obesity ; hypoglycemia ; meta-analysis ; nephropathy ; urine albumin-creatinine ratio ; diabetes complications ; coronavirus infections ; hypoglycemic agents ; ambulatory care ; comorbidity ; glucagon-like peptide-1 receptor agonist ; HbA1c ; real-world evidence ; semaglutide ; SURE study ; pneumatosis intestinalis ; alpha-glucosidase inhibitors ; acarbose ; voglibose ; miglitol ; comorbidities ; concomitant drugs ; prednisone ; immunosuppressants ; n/a ; depression ; sex ; in-hospital mortality ; readmission ; empagliflozin ; SGLT-2 ; monocytes ; endothelial cells ; vascular dysfunction ; chemotaxis ; reactive oxygen species (ROS) ; glucose transport ; VEGFR-2 ; VEGFR-1 ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This Special Issue, entitled the “Synthesis of Heteroaromatic Compounds”, is an outstanding collection of fourteen original research papers and six review articles that discuss the advances made in both conventional and green preparatory methods, as well as the properties and applications of heteroaromatic molecules in industrial and medicinal chemistry areas of study.The collected works featured herein collate contributions from a truly international and diverse array of ninety experts in the fields of heteroaromatic compound synthesis, QSAR studies, computational chemistry and molecular docking, as well as bioactivity studies.
    Keywords: heteroaromatics ; C-H bond functionalization ; oxidative cyclization ; cross-coupling ; amination ; triazoles ; palladium ; carbene ligands ; heterocycles ; nitrogen-containing heterocycles ; synthesis ; antiviral agents ; viruses ; COVID-19 ; inhibition ; Mpro inhibitors ; drug design and synthesis ; structure-activity relationships (SAR) ; s-tetrazine ; 4H-1,2,4-triazole ; pinner reaction ; 1,2,3-triazole ; fused 1,2,3-triazole ; 1,2,3-triazolo[4,5-b]pyrazine ; 1,2,3-triazolo[4,5-c]pyridazine ; 1,2,3-triazolo[4,5-d]pyridazine ; 1,2,3-triazolo[1,5-a]pyrazine ; 1,2,3-triazolo[1,5-b]pyridazine ; triazolopyrazine ; triazolopyridazine ; practical applications ; spiro π-conjugated compound ; chiral compound ; thiophene ; furan ; pyrrole ; nucleophilic aromatic substitution ; circular dichroism ; circularly polarized luminescence ; pyridines ; 1,3,4-thiadiazoles ; 1,3-thiazoles ; hydrazonoyl halides ; molecular docking ; anticancer activity ; 1,3,4-oxadiazoles ; organic ligands ; substitution ; diisopropyl iminodiacetate ; pyrimidine ; benzimidazole ; aza-Diels–Alder reaction ; Povarov reaction ; oxidation ; fluorescence ; aggregation-induced emission ; mechanochromic properties ; heterocycle ; natural product ; nicotinic acid ; fungicidal activity ; 4-pyrone ; DMF-DMA ; enamination ; cycloaddition ; merocyanine ; 1,6-conjugate addition ; solvatochromism ; fluorophore ; acetylcoumarin ; thiazoles ; VEGFR-2 ; polyfluoroflavones ; 1H-1,2,4-triazole ; imidazole ; regioselectivity ; azolyl-substituted flavones ; photoluminescence ; 4-pyridone ; oxazinone ; ring-opening ; aldehyde-lactol tautomerism ; ammonium acetate ; diazirine ; medicinal chemistry ; photoaffinity labeling ; metathesis ; carboaromatics ; 4,5-dihydro-5-oxo-pyrazolo[1,5-a]thieno[2,3-c]pyrimidines ; novel scaffold ; molecular dynamic studies ; proximity frequencies (PF) ; GABAA receptor subtype ; GABAA receptor ligands ; antibacterial ; anticancer ; antifibrotic ; antifungal ; antimicrobial ; antiviral ; appel salt ; 1,2,3-dithiazole ; disulfide bridge ; herbicidal ; chalcone ; heteroaromatic ; hybrid chalcone ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PN Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Major concerns regarding health and the environment are at the heart of the United Nations Educational, Scientific and Cultural Organization's Sustainable Development Goals. Now more than ever, humanity is called upon to take action to protect the environment and public health. The environment in which we live is the most vital factor for our health and well-being. Human activities have significant impacts on the atmosphere, lithosphere, hydrosphere, biosphere, and even outer space. Biological, chemical, and physical risk factors are part of our everyday lives, and scientific research continuously faces challenges to understand and mitigate these interactions to make life on Earth more sustainable. The sustainability of human societies and the biodiversity that supports them requires the responsible supervision of natural resources, including the development of technologies and regulations.
    Keywords: Acinetobacter baumannii ; biofilm ; citric acid ; combined disinfection ; infection prevention ; infection control ; ozone ; food safety ; hygiene ; mountaineers ; excursionist ; disinfection ; opportunistic pathogens ; Pseudomonas fluorescens ; UV light ; COVID-19 ; surveillance ; outbreaks ; educational settings ; children ; consumers ; knowledge ; practice ; observation ; construction waste decreasing ; evolutionary game ; sewage discharge fees ; fine ; numerical simulation ; growth character ; rebellious character ; beetle swarm optimization ; test function ; local optimum ; character decision ; Baiyangdian basin ; land use/cover change ; eco-environmental quality index ; spatio-temporal pattern ; GeoDetector ; factor detector ; interaction detector ; terpenoids ; food-borne bacteria ; minimum inhibitory concentration ; viability ; biomass ; primary school ; indoor air quality factors ; outdoor air quality factors ; questionnaire ; cross-sectional study ; maize disease ; adversarial training ; context feature aggregation ; patch embedding ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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  • 177
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Interactions between nucleic acids and proteins are essential requirements for the viability of cellular life because they are indispensable for many basic biological processes. DNA is typically presented as a specific double-stranded helical structure, but nucleic acids have great structural flexibility. Current knowledge demonstrates that the structural conformations of nucleic acids play critical roles in protein–DNA interactions. This book presents a collection of research findings published in the Special Issue of the International Journal of Molecular Sciences, titled “Impacts of Molecular Structure on Nucleic Acid-Protein Interactions”.The breadth of research findings reported here demonstrates that the structural flexibility of nucleic acids plays critical roles in their interactions with proteins, with important implications across a range of human diseases, including cancer and some infectious diseases.Prof. Richard BowaterUniversity of East Anglia, Norwich, United KingdomProf. Václav BrázdaInstitute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic
    Keywords: DNA ; RNA ; protein binding ; G-quadruplex ; triplex ; i-motif ; Z-DNA ; Z-RNA ; cruciform ; amino acid composition ; COVID-19 ; SARS-CoV-2 ; coronavirus ; CNBP ; virus ; bioinformatics ; coevolution ; host ; dsDNA ; G4Hunter ; evolution ; plant science ; nucleic acids ; circular dichroism ; UV light ; ligand ; rhodamine ; thiazole orange ; thioflavin T ; p53 ; aging ; longevity ; comparative analysis ; protein sequence ; Drosophila ; polytene chromosomes ; Canton-S ; agnostic ; ectopic pairing ; 1.688 repeats ; 372-bp repeats ; fragile X-associated primary ovarian insufficiency (FXPOI) ; fragile X-associated tremor/ataxia syndrome (FXTAS) ; fragile X syndrome (FXS) ; repeat instability ; repeat expansion ; chromosome fragility ; RNA gain-of-function ; repeat-associated non-AUG (RAN) translation ; repeat-mediated gene silencing ; Zα domain ; orthogonal representation ; algorithm ; toehold switch ; arithmetic operation ; RNA–RNA interaction ; molecular computing ; reversible computing ; DNA base sequence ; DNA structure ; DNA supercoiling ; epigenetics ; genome stability ; inverted repeat ; replication ; transcription ; nucleic acid–protein interactions ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Energy and its economic implications have been in the spotlight of policymakers, academics, traders, speculators and the industry for decades now. It has been an active research topic for more than 150 years. From the 19th century, the problem of creating, processing, storing and transporting energy was well defined. The issues of efficiently producing, pricing, distributing, and forecasting the demand, supply and prices of energy-related products and services are central to most modern economies irrespective of their level of development. These issues are apparent in times of relative tranquility in the respective markets but become central for all stakeholders in times of turbulence. This volume focuses on emerging methodologies of analysis, description, modelling, and forecasting in the topical area of Energy Economics. Includes emerging and innovative methodological approaches from the areas of machine learning, artificial intelligence, econometrics, and statistics aimed to model, describe or forecast the energy markets at all levels. Additionally, the volume also presents a bibliographical review, summarizes and compares results of different studies in the energy-sustainable economic growth and development nexus. The practical importance of the results to all energy market stakeholders in terms of regulating, pricing, and distributing energy is evident. Theoretical robustness, methodological innovation, and possible direct applicability of the conclusions were the basic requirements for research work to be included in this publication.
    Keywords: economic growth ; innovation activity ; globalization ; international trade ; uncertainty ; spillovers ; realized variance ; crude oil ; forecasting ; bibliometric analysis ; development economics ; energy ; renewable energy ; energy-growth nexus ; sustainable economy ; new economics ; critical review ; natural gas ; spot price ; machine learning ; energy commodities ; financial crises ; Brent ; WTI ; gasoline ; clustering ; t-SNE ; COVID-19 pandemic ; target model ; Greek wholesale electricity market ; day-ahead market ; intraday market ; balancing market ; trading volumes ; COVID-19 ; pandemic ; energy market volatility ; announcements ; deaths ; infections ; load forecasting ; load series ; mode decomposition ; extreme learning machine ; kernel density estimation ; geopolitical risk ; renewable energy sources ; energy production ; ARDL ; GDP ; CO2 emissions ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PH Physics
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: Carbazoles are important aromatic heterocyclic compounds isolated from plants or synthetically obtained. Today, many carbazole derivatives are used in different industrial sectors, especially in the fields of physical chemistry, materials chemistry, and pharmaceuticals. In this Special Issue, “Carbazole derivatives: latest progress and prospects”, recent studies on carbazole derivatives that are utilized, such as β1-blocking, anticancer (e.g., STAT inhibitors, microtubule-targeting agents), and antidiabetic as well as antiviral (e.g., for the treatment of COVID-19 infection) agents, are reported.
    Keywords: β-blockers ; carbazole ; indole ; molecular docking ; H9c2 cells ; cardiac hypertrophy ; carbazoles ; heterocycles ; STAT proteins ; STAT inhibitors ; target STATs ; tumoral cells ; ellipticine ; tubulin ; breast cancer ; apoptosis ; docking simulations ; alkaloids ; diabetes mellitus ; antihyperglycemic agents ; COVID-19 ; coronaviruses ; SARS-CoV-2 ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Sudden cardiac death (SCD) affects more than four million patients per year worldwide, and accounts for up to 50% of all cardiovascular deaths. Related to the improved treatment options for cardiovascular diseases during the past several decades (e.g., improved guideline adherence to pharmacotherapies, increasing supply with cardiac devices, and better revascularization strategies), the characteristics of patients presenting with SCD have significantly changed, making risk prediction for SCD even more complex. The present Special Issue reprint addresses the prognostic impact of patients’ characteristics (such as body mass index), airway and ventilation management in patients needing cardiopulmonary resuscitation, and the prognostic value of a targeted ambulance treatment quality improvement programme. Furthermore, the prognostic value of blood-derived biomarkers and cardiac pharmacotherapies for the prevention of SCD was investigated.
    Keywords: ventricular tachycardia ; ventricular fibrillation ; mortality ; ACE inhibitor ; ARB ; medical treatment ; pharmacological drugs ; gamma-glutamyl transferase ; metabolic syndrome ; sudden cardiac death ; ammonia ; cardiopulmonary resuscitation ; neurological outcome ; biomarkers ; cardiac arrest ; intensive care ; levosimendan ; inotropy ; ventricular tachyarrhythmias ; cardiac troponin I ; coronary artery disease ; n/a ; coronary angiography ; neurological sequelae ; quality of life ; temporal variability ; COVID-19 ; coronavirus ; out-of-hospital cardiac arrest (OHCA) ; resuscitation ; porcine ; ventilation ; MIGET ; EIT ; airway management ; advanced life support ; emergency medical service ; tracheal intubation ; videolaryngoscopy ; intra-arrest hypothermia ; sudden cardiac arrest ; N-terminal of the prohormone brain natriuretic peptide predicts postoperative (NT-proBNP) ; valve surgery ; emergency treatment ; invasive procedures ; heart massage ; circulation ; clamshell thoracotomy ; extra-corporeal membrane oxygenation ; echocardiography ; resuscitative endovascular balloon occlusion of the aorta ; out-of-hospital cardiac arrest ; quality improvement ; ROSC ; ambulance crew ; underweight ; diabetes mellitus ; body-mass index ; waist circumference ; central obesity ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This reprint is a compilation of the articles and reviews published in the Special issue entitled "Controversies and Recent Advances in Senescence and Aging" in Cells. The Editorial summarises and highlights the contents of the published articles. Aging is the leading predictive factor of many chronic diseases that account for most of the morbidity and mortality worldwide, i.e., neurodegeneration, cardiovascular, pulmonary, renal, and bone diseases, as well as cancers. Oxidative stress and reactive oxygen species generation, the over-production of inflammatory cytokines, the activation of oncogenes, DNA damage, telomere shortening, and the accumulation of senescent cells are all widely accepted mechanisms contributing to aging. Senescence is mainly thought to be provoked by negative cellular stress but might also be induced by physiological developmental stimuli. Senescence is characterized by irreversible cell cycle arrest independent of quiescence and terminal differentiation. The Special Issue entitled “Controversies and Recent Advances in Senescence and Aging”, which is contained in this reprint, comprises an excellent collection of original articles and reviews highlighting different novel aspects in the fields of senescence and aging research. They will hopefully stimulate discussions and further research in these fields, which are extremely important in a constantly aging human population.
    Keywords: aging ; endothelial cells ; development ; liver ; heart ; brain ; kidney ; senescence ; SASP ; ageing ; senolytics/senostatics ; p16Ink4a ; p19Arf ; p21Waf1/Cip1 ; replicative senescence ; DNA damage response ; telomerase and telomeres ; TGF-β signalling ; pulmonary fibrosis ; COVID-19 ; natural killer cells (NK cells) ; immunosenescence ; elderly ; frailty ; cytokines ; inflammation ; immune system ; sarcopenia ; NLRP ; pyroptosis ; gasdermin ; aging-related disease ; mouse model ; melanocyte ; melanoma ; beta-galactosidase ; telomerase/hTERT ; anti-cancer ; sanguinarine chloride ; cellular senescence ; multinucleation ; retinal pigment epithelium ; reactive oxygen species ; photoreceptor ; DNA damage ; p53 ; telomeres ; telomerase ; shelterin ; moderate exercise ; high-fat diet ; Sprague Dawley rats ; lung diseases ; asthma ; COPD ; remodeling ; mitochondrial dysfunction ; metabolic function ; stem cells ; lysosome ; lifespan ; duox ; ROS ; Drosophila melanogaster ; air pollution ; skin aging ; cosmetics ; short-chain fatty acids ; neutrophil ; HIV ; women ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 182
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Psychiatric disorders in children and adolescents are relevant both in terms of their prevalence (they are roughly estimated to affect about 20% of school-aged children and adolescents) and of their impact on the quality of life of the child/adolescent and their family, but also on the society as a whole. Disorders affecting children and adolescents are increasingly seen as having highly specific features, and, therefore, require an equally specific approach despite the coexisting need to integrate contributions from other professions (e.g., pediatricians, psychiatrists, psychologists, and therapists of different sorts). However, the available data are still insufficient, especially for treatment options and too often therapeutic choices are still made based on studies conducted in adults. Even more important, the existence itself of some disorders is questioned especially outside the scientific field (e.g., ADHD). This Special Issue provided cutting edge data on different aspects of child and adolescent psychiatry, including etiopatogenesis, clinical characteristics and diagnosis, medical and neurological comorbidities (and psychiatric comorbidities of medical and neurological disorders), impact on patients/families/society (including school and other social groups), prognosis, and treatment options of the different disorders.
    Keywords: social withdrawal ; alexithymia ; adolescence ; psychological disorders ; anxiety ; depression ; social problems ; videogames ; internet gaming disorder ; child behavior checklist ; post traumatic stress disorder ; refugee ; screening ; COVID-19 ; dyslexia ; reading skills ; learning disability ; attention deficit disorder with hyperactivity ; child ; adolescent ; mental health ; chronic disease ; register ; clinical protocol ; trans adolescents ; psychological distress ; internalizing problems ; YSR-R/CBCL-R ; parental congruence ; peer relations ; gender minority stress ; earthquake ; trauma ; PTSD ; parental psychopathology ; internalizing disorders ; youths ; children ; adolescents ; children and adolescents ; clinical practice ; early intervention ; interpersonal violence ; sexual abuse ; grandiose-manipulative ; callous-unemotional ; daring-impulsive ; psychopathy ; early adolescent ; conduct problems ; hyperactivity ; pediatric conditions ; psychiatric genetics ; anger ; self-regulation ; aneuploidy ; autosomal trisomy ; vocal stereotypies ; autism spectrum disorder ; automatic reinforcement ; stimulus control ; changing criterion design ; mental imagery ; social pain ; child and adolescent psychiatry ; inpatient ; day-clinic ; outcome quality ; treatment satisfaction ; quality of life ; Autism Spectrum Disorder ; social problem-solving skills ; interpersonal skills ; treatment ; assessment ; generalization ; n/a ; Child and Adolescent Mindfulness Measure (CAMM) ; reliability ; validity ; cutoff ; primary school students ; Chinese ; congenital heart disease ; health-related quality of life ; questionnaire ; anorexia nervosa ; family functioning ; Lausanne Trilogue Play ; restrictive eating disorders ; psychosocial difficulties ; daily performance ; play performance ; activities of daily living ; occupational therapy ; participation ; school-aged ; typically developing ; lockdown ; mood disorders ; chronic illness ; pandemic ; childhood ; positivity ; intolerance of uncertainty ; psychopathological symptoms ; psychological adjustment ; longitudinal study ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Nurses represent the highest number of healthcare workers globally and have played a critical role in the COVID-19 pandemic. This reprint highlights the issues and challenges faced by nurses practicing in hospital and community settings during the COVID-19 pandemic. The manuscripts herein focus on nurses in various areas of practice, including nurse managers, highlighting the impact, experience, and reality of providing care during the crisis. Interventions and strategies to support practice environments and the mental health and wellbeing of the nursing workforce were identified. Evidence from these manuscripts shed light on how nurse leaders can provide relevant, coordinated, and consistent organizational and leadership support to better establish a safe and healthy work environment that protects and fosters the mental health and wellbeing of all nursing personnel. The pandemic exacerbated the already demanding quality of work environments for nurses, as well as their mental health and wellbeing, thereby inducing a global nursing shortage; therefore, improving these factors, which ultimately influence nurse retention, is critical. We trust that sharing the lived experiences of nurses during the COVID-19 pandemic can enable us to leverage their expertise in meeting the complex care needs of patients, including COVID-19 patients, while improving the care needed by nurses in their working environments, alongside preparing for future pandemic waves.
    Keywords: SARS-CoV-2 ; pandemic ; confinement ; Spain ; depression ; anxiety ; COVID-19 ; health workforce ; nursing students ; professional identity ; qualitative study ; volunteers ; nurse ; willingness ; relational capital ; post-traumatic growth ; psychological security ; work meaning ; coronavirus disease 2019 (COVID-19) ; junior nurses ; transformational experience ; personal protection equipment (PPE) ; protective equipment ; emergency medical services ; post-traumatic stress disorder ; mental status ; sleep disorders ; COVID-19 pandemic ; sexism ; female nurses ; gender equity ; gender bias ; female stereotype ; nursing records ; patient isolation ; nursing care ; nurses ; long-term care ; community nursing ; coronavirus ; workforce ; spirituality ; palliative care ; nursing skills ; end-of-life ; symptoms ; depression symptoms ; frontlines ; meta-analysis ; systematic review ; public health ; insomnia ; nursing ; mitigation measures ; care homes ; wellbeing ; care ethics ; relational care ; narratives ; infectious diseases ; caregiving ; qualitative research ; psychosocial burden ; psychosocial risk scale ; nurse management ; crisis management ; primary healthcare ; COVID-19 ambulatory care ; in-action review ; novel infectious disease ; burnout ; job stress ; resilience ; changes in outlook ; influencing factors ; crisis response ; topic modeling ; ultra-Orthodox ; transcultural ; minority ; cultural competence ; mixed methods ; cross-cultural ; item response theory ; measurement invariance ; mental health ; nursing staff ; pandemics ; validation ; WHO-5 Well-Being Index ; correctional nurses ; occupational health ; work conditions ; prison ; management ; professional roles ; survey ; potentially morally injurious event (PMIE) ; turnover intentions ; basic psychological need satisfaction ; episodic memories ; self-determination theory ; self-disclosure ; perceived autonomy support ; coping strategies ; health ; students ; bic Book Industry Communication::M Medicine
    Language: English
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  • 184
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The reprint “Sustainable Healthy Working Life for All Ages—Work Environment, Age Management and Employability” provide an outlet of research contributing to the development of theoretical and practical knowledge influencing people’s working life. Working life is complex and there are many different factors that influence, such as the demographic change, pandemic and rapid technological development, etc., which place constantly changing demands on both employees, organizations/companies and society in different countries. This reprint covers new knowledge, as identified factors and areas that affect employees' ability to work to an older age, interventions and measures that enable a healthy and sustainable working life throughout the entire working life journey, from young to senior employees. The reprint also addresses the pressured work situation of school leaders in managing the education of children and young people in society, and what makes them stay or leave their jobs. In addition, the reprint addresses the way in which the Covid-19 pandemic has affected working life, not least for the health care professional groups and organizations.
    Keywords: work resources ; work ability ; forest industry ; timber harvesting ; restructuring ; COVID-19 ; coronavirus ; COVID-19 phobia ; school administrator ; work–family conflict ; family–work conflict ; life satisfaction ; lifestyle health ; stratified consumption structure ; self-rated health ; regional differences ; intergenerational program ; swAge ; social capital ; trust in colleagues ; employability ; ageing ; work environment ; swAge-model ; demography ; retirement ; work–life balance ; discrimination ; competence ; older worker ; senior worker ; extended working life ; age management ; sustainable work ; employment ; well-being ; older workers ; aging ; person-centred ; organization ; nurse ; abuse ; long-term care ; wellbeing ; workforce ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine
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  • 185
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Cardiothoracic and pulmonary diseases are a significant cause of mortality and morbidity worldwide. The COVID-19 pandemic has highlighted the lack of access to clinical care, the overburdened medical system, and the potential of artificial intelligence (AI) in improving medicine. There are a variety of diseases affecting the cardiopulmonary system including lung cancers, heart disease, tuberculosis (TB), etc., in addition to COVID-19-related diseases. Screening, diagnosis, and management of cardiopulmonary diseases has become difficult owing to the limited availability of diagnostic tools and experts, particularly in resource-limited regions. Early screening, accurate diagnosis and staging of these diseases could play a crucial role in treatment and care, and potentially aid in reducing mortality. Radiographic imaging methods such as computed tomography (CT), chest X-rays (CXRs), and echo ultrasound (US) are widely used in screening and diagnosis. Research on using image-based AI and machine learning (ML) methods can help in rapid assessment, serve as surrogates for expert assessment, and reduce variability in human performance. In this Special Issue, “Artificial Intelligence in Image-Based Screening, Diagnostics, and Clinical Care of Cardiopulmonary Diseases”, we have highlighted exemplary primary research studies and literature reviews focusing on novel AI/ML methods and their application in image-based screening, diagnosis, and clinical management of cardiopulmonary diseases. We hope that these articles will help establish the advancements in AI.
    Keywords: lung ; conventional radiography ; diagnostic procedure ; chronic obstructive pulmonary disease ; COVID-19 ; computed tomography ; lungs ; variability ; segmentation ; hybrid deep learning ; artificial intelligence ; deep learning ; computer-based devices ; radiology ; thoracic diagnostic imaging ; chest X-ray ; CT ; observer tests ; performance ; lung CT images ; nodule detection ; VGG-SegNet ; pre-trained VGG19 ; cardiac amyloidosis ; AL/TTR amyloidosis ; hypertrophic cardiomyopathy ; left ventricular hypertrophy ; convolutional neural network ; Tuberculosis (TB) ; drug resistance ; chest X-rays ; generalization ; localization ; Electrical Impedance Tomography ; lung imaging ; cardiopulmonary monitoring ; aorta ; lung cancer ; pulmonary artery ; pulmonary hypertension ; modality-specific knowledge ; object detection ; RetinaNet ; ensemble learning ; pneumonia ; mean average precision ; source data set ; supervised classification ; coronary artery disease ; machine learning ; cardiopulmonary disease ; faster CNN ; medical imaging ; X-rays ; transfer learning ; explainability ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
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  • 186
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: Robotics and intelligent systems are key technologies to promote efficient and innovative applications in the most diverse domains (industry, healthcare, agriculture, construction, mobility, etc.), performing and supporting activities that are not suitable to be performed by humans. Such activities are frequently time-consuming, repetitive tasks with low added value, which are physically demanding and/or dangerous. Nevertheless, robotics and intelligent systems face several scientific and technological challenges related to their integration and interoperability with other systems, safety, flexibility, re-configurability and autonomy. These challenges are especially relevant when robots operate in real unstructured environments and share a workspace with humans and other equipment. This reprint collects research achievements, ideas, and applications regarding advanced intelligent robotic systems, covering diverse technologies and application domains. Generically, the contributions cover optimal path-planning strategies and innovative designs for mobile manipulators, the integration of robotic and intelligent systems, grasping, manipulation, teleoperation, haptics, user experience approaches for collaborative robots, and multi-agent systems.
    Keywords: robot ; manipulator ; robotized workplace ; robotic cell ; optimization ; wear ; motion planning ; trajectory tracking ; mobile manipulator ; joint constraints ; self-collision avoidance ; manipulability ; service robot ; assistant robot ; collaborative robot ; healthcare ; elderly care ; intelligent systems ; COVID-19 ; multi-agent systems ; bigraphs ; design ; verification ; modeling ; non-functional requirements ; robot path planning ; RRT ; midpoint interpolation ; triangular rewiring ; path smoothness ; non-prehensile manipulation ; manipulation planning ; pivoting ; robotics ; mobile manipulation ; large-scale inspection ; wind turbine production ; autonomous navigation ; surface-orthogonal path planning ; intelligent robot ; flexible production ; manipulation ; intelligent control ; User eXperience ; human–robot interaction ; human–robot collaboration ; human-centered design ; augmented reality ; human factors ; omnivehicle ; omnitracks ; Mecanum rollers ; FDM ; simultaneous localization and mapping ; dual lidar inertial odometry ; IMU ; time synchronization ; tight coupling ; impact hammers ; industrial robotics ; haptic teleoperation ; underground mining ; genetic algorithm ; principal component analyses ; standard triangle language ; traveling salesman problem ; trajectory planning ; haptic recognition ; convolutional neural network ; channel attention ; spatial interactive second-order feature ; multiorder feature ; n/a ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 187
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Polyphenols are natural phytochemicals recognized as one of the largest and most widespread classes of plant constituents occurring throughout the plant kingdom. Over the years, polyphenols have attracted the attention of the scientific community due to their potential health-promoting effects. Owing to their several interesting properties, polyphenols have aroused considerable interest, shedding light on their chemistry, reactivity, biological properties and their beneficial effects on both plants and humans. As a result of these investigations, a huge number of research works have been reported on polyphenols. However, despite the voluminous literature studying polyphenols and their impact on human health, there are still many issues waiting to be explored in order to explain and elucidate the positive effects of polyphenols on human health. This Special Issue was intended to gather up-to-date knowledge related to the cutting-edge research in the broad scientific area of polyphenols, providing an opportunity to show the latest advances in the exploration of polyphenols and their health beneficial effects. The special issue was a great success with more than 50 published manuscripts covering various aspects related to polyphenols and their role in human health. We are confident that this Special Issue will be of great interest to the scientific community, and will contribute to the improvement of knowledge regarding the area of polyphenols, leading to a better understanding of their role in human health.
    Keywords: polyphenolic curcumin ; cisplatin ; combination therapy ; breast cancer ; apoptosis ; gemini surfactant nanoparticles ; Mucuna pruriens seed ; neuroprotective activity ; Parkinson’s disease ; anti-acetylcholinesterase activity ; L-dopa ; Mitrephora sirikitiae ; anti-inflammation ; lignans ; polyphenols ; mRNA expression ; cytokines ; gemini curcumin ; colorectal cancer ; RNA sequencing ; PPI network ; differentially expressed genes ; Ericaceae ; LC–DAD/ESI–MS ; phenolic compounds ; flavonoids ; antioxidant activity ; Artemia salina Leach ; resveratrol ; hexavalent chromium ; 8-hydroxydeoxyguanosine adduct repair ; endogenous antioxidant system ; antigenotoxic ; Opuntia sp. ; prickly pear ; inflammation ; ginseng leaf ; far-infrared irradiation ; ginsenosides ; antioxidants ; health benefits ; polysaccharides ; freeze-drying ; spray-drying ; antidiabetic ; Averrhoa carambola L. ; dihydrochalcone ; flavone glycosides ; obesity ; Oxalidaceae ; type 2 diabetes ; Alchemilla viridiflora Rothm. ; SARS-CoV-2 ; COVID-19 ; spike glycoprotein ; neuropilin-1 ; in vitro ; in silico ; Origanum compactum ; HPLC-PDA-ESI/MS ; antibacterial activity ; bioactive compounds ; nutraceuticals ; phenols ; pomegranate peels ; phytochemical ; wistin ; NADES ; total polyphenolic content ; enzyme inhibition ; functional food ; natural medicine ; Alzheimer cholinesterase inhibitors ; Maqui ; platelets ; phenolic compounds and cardiovascular ; phenolic acids ; sinapic acid ; ACE inhibition ; hypertension ; endothelial dysfunction ; Graminex pollen ; hydroalcoholic extract ; oxidative stress ; gene expression ; TRPV1 ; pterostilbene ; antioxidant ; bioavailability ; cancer ; diabetes ; Nrf2 ; Rosmarinus officinalis ; chemical analysis ; glioblastoma ; rhabdomyosarcoma ; red onion ; phytochemicals ; H9c2 rat cardiomyoblast ; primary human fibroblasts ; blood disorder ; haemoglobin ; natural product ; nutraceutical ; nutritional disease ; lichens ; neuroprotection ; cetrarioid clade ; grape polyphenols ; sarcopenia ; skeletal muscle ; clinical trial ; R. conduplicans ; lichen ; secondary metabolites ; DNA damage ; α-glucosidase inhibition ; adlay ; adlay testa ; antiglycation ; phenolic acid ; grape pomace ; anti-inflammatory ; curcumin ; poly(glycerol sebacate) ; nanoparticles ; drug delivery system ; human cervical cancer ; baicalein ; mangiferin ; quercetin ; diabetes mellitus ; peripheral artery disease ; cardiovascular diseases ; Cyperus esculentus ; tiger nut ; metabolomics ; UHPLC-ESI-QTOF-MS/MS ; foodomics ; scopolamine ; memory impairments ; phenol compounds ; polydatin ; 3-O-β-d-resveratrol-glucopyranoside ; cervical cancer ; lung cancer ; ovarian cancer ; nanosuspension ; antioxidant properties ; LPS-induced inflammation ; NO-scavenging activity ; mountain tea ; Lamiaceae ; iridoids ; phenylethanoids ; ultrasound-assisted extraction ; melittoside ; ajugoside ; verbascoside ; ferulic acid ; apoptosis and cell cycle arrest ; anti-angiogenesis ; anti-metastasis ; synergism ; Cymbopogon schoenanthus ; hyaluronidase ; acetylcholinesterase ; neurodegeneration ; skin ; hair ; human health ; immobilized PTP1B ; drug screening ; cell surface display ; salvianolic acid B ; traditional Chinese medicine ; Salicornia ; extraction technologies ; agro-industrial by-products ; biological activity ; circular economy ; health effects ; re-integration ; waste management ; blood orange peels ; infrared-assisted extraction ; optimization ; Aflatoxin B1 ; Achillea millefolium ; bioaccessibility ; Caco-2 absorption ; in vitro digestion ; sterol regulatory element-binding protein 1 ; human oral squamous cell carcinoma ; autophagy ; epidermal fatty acid-binding protein ; lentil hull ; enzymatic hydrolysis ; microwave-assisted extraction ; oligosaccharides ; Alocasia gigantea ; hepatocellular carcinoma ; histopathology ; UHPLC–DAD–ESI–MS/MS ; Salvianolic acid B ; matrix metalloproteinase 9 ; gelatinase B ; MDA-MB-231 human breast cancer cells ; TIMP-1 ; agri-food wastes ; sustainability ; polyphenols bioavailability ; polyphenols activity ; cosmeceuticals ; nano-delivery ; health ; Lithocarpus litseifolius ; trilobatin ; phloridzin ; phloretin ; metabolic pathway ; bioactivity ; honey ; functional beverage ; characterization ; alcoholic beverage ; fermented beverage ; functional foods ; beneficial effects ; biological treatment ; bioreactors ; water ; aerobic granular sludge ; conventional active ted sludge ; biofilter ; photobioreactor ; membrane bioreactor ; bio-electrochemical systems ; chitosan ; Indian borage ; biotic elicitor ; insect-based foods ; Folin–Ciocalteu method ; phenols and flavonoids ; polyphenols bioactivity ; cereal ; pre-harvest sprouting ; antiradical capacity ; antitumor activity ; bee products ; phenylamides ; multivariate statistical analysis ; Juniperus sabina ; cupressuflavone ; intranasal ; pharmacokinetic ; motor coordination ; oregano ; box–behnken ; phenolics ; HPLC-PDA analysis ; UPLC-Q-TOF MS ; olive pomace ; PBMC ; immune gene expression ; HPLC-DAD ; metabolome ; phenolic bioaccessibility ; propolis ; total phenolic compounds ; antioxidant capacity ; UHPLC-DAD-ESI-MS ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 188
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-30
    Description: The present reprint contains 11 articles accepted for publication and published in the Special Issue From COVID-19 to Resilience: Quantitative Methods in Economics and Business of the MDPI Mathematics journal. These articles cover a wide range of topics analyzing economics and business situations during and post the COVID-19 pandemic. It is hoped that these selected research papers will be found to be impactful by the international scientific community and that these papers will facilitate further research on quantitative techniques for solving complex problems in various disciplines and application fields.
    Keywords: COVID-19 ; tourism industry ; hospitality sector ; interval-valued intuitionistic fuzzy set ; k-means clustering ; system structural harmonicity ; synergetics ; orderliness ; entropy ; generalized golden ratio (GGR) ; quantitative assessment ; road safety ; COVID-19 epidemic ; Russia ; Anscombe’s quartet ; Cook’s distance ; default rate ; expected credit loss ; gross domestic product ; commodities ; structure of copper futures prices ; cointegration ; contango ; backwardation ; extreme event contexts ; entrepreneurial resilience ; creative performance ; institutional orientation ; SEM ; telecommunications ; broadband ; digitization ; resilience ; pandemics ; business performance ; financial analysis ; COVID-19 pandemic ; construction sector ; Slovak enterprises ; rural hospitality and tourism ; agritourism ; micro-businesses ; agritourism performance ; support for agritourism development ; personal resident benefit ; resident–micro-business interaction ; COVID-19 news ; volatility ; granger causality ; time-varying ; time series ; financial markets ; MSGARCH ; symmetry ; regime changes ; safe haven ; hedge properties ; Bitcoin ; gold ; government bond price volatility ; government policy responses ; international financial markets ; containment and closure ; economic support ; panel quantile regression ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCM Development economics and emerging economies
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  • 189
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-08
    Description: Catholic education faces many challenges, mainly due to secularisation. This applies to both content and methods, as well as teacher training. In response to these challenges, the publication titled "Catholic Education" has been prepared. This topic is understood very broadly and includes all dimensions of education provided within the Catholic Church, in Catholic schools and Catholic communities around the world. The main aim of this reprint is to specify and answer new challenges for Catholic education and Catholic religious education that arise from secularisation and other reasons. This reprint contains 17 chapters authored by researchers from various countries and different traditions. Drawing from their diverse experiences, they not only address the issues within their own environments but also analyse global problems. Papers presenting Catholic education and Catholic religious education in historical, contemporary, and future perspectives are also present.
    Keywords: baptism ; God ; values ; community ; parish ; duties ; parents of the child receiving baptism ; godparents ; lay Catholics ; formation ; St. Francis ; Franciscan spirituality ; religious education ; Poland ; youth ; religiosity ; adaptive religious education ; constructivist approach ; student-centred approach ; religious dimension of intercultural education ; intercultural education ; intercultural competence ; religious education teachers ; religiousness ; religious lessons ; Catholic education ; sociology ; pastoral theology ; Catholic school leaders ; interruption ; practical wisdom ; educational design research ; soft strategies ; reflective questions ; freedom of religion ; COVID-19 ; Catholic Church ; communication ; faithful ; canon law ; liturgy ; media ; pandemic ; pragmalinguistic ; Catholic schools ; faith formation ; teachers ; Christian anthropology ; transcendentals ; religious motivations ; young Catholics ; marriage ; pastoral care of families ; empirical theology ; Catholic school ; capitalism ; capitalism index ; economic ideology ; Benin ; fiancé ; girls ; convent ; Roman Catholic ; nuns ; interdenominational rivalry ; Mariology ; Vatican II ; seminaries ; Congregation for Catholic Education ; Program for Priestly Formation ; sexual morality ; Benedictine hospitality ; language learning ; communities ; liminal ; liminoid ; ACTFL ; internet ; loneliness ; socialisation ; leisure ; young people ; bic Book Industry Communication::H Humanities::HR Religion & beliefs ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRL Aspects of religion (non-Christian)::HRLB Theology ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRV Aspects of religion::QRVG Theology
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  • 190
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Ageing is a diverse and multifaceted experience that is unique to each person. The process of ageing is lived differently according to each individual’s socio-cultural, historical, religious, and political context, among other factors. However, the stereotype of homogeneity is still one of the strongest aspects related to later life. This Special Issue covers manuscripts of original research that critically explore the experience of old age and the process of growing older from the social sciences and humanities perspectives. It also explores the topics pertaining to social gerontology, cultural and literary gerontology, environmental gerontology, gerotechnological studies, social anthropology, gender studies, body politics, sexuality, active and healthy ageing, space and place, age-friendly politics and other themes. The published articles collect arguments that show the variables and uniqueness of later life, and expand on the current theoretical frameworks in the field of age studies and beyond. The overall aim of this Special Issue was to broaden the gerontological scholarship and develop critical thought of old age and the life course beyond the merely biological processes of growing older and their sociocultural constructs. This Special Issue can be of interest to scholars, practitioners, stakeholders, care workers and individuals who are concerned with the dynamics of ageing as well as current and future dialogues on the unique experiences of ageing.
    Keywords: ageing ; older adults ; intimacy ; creativity ; strict morality ; sexuality ; theories of retirement ; rhythmanalysis ; management of time ; interdisciplinary gerontology ; busy ethic ; societal rhythms ; home ; identity ; Ireland ; place attachment ; rural ; Sweden ; women ; inclusivity ; Zimbabwe ; urban environments ; discourse analysis ; urban policy ; Africa ; ageism ; COVID-19 ; fourth age ; nursing homes ; third age ; cultural and literary gerontology ; aging and society ; agism ; popular culture and comics ; DC superheroes ; aging in place ; dementia ; cognitive changes ; design practice ; user involvement ; participatory design ; socio-gerontechnology ; active ageing ; age-friendly ; age panic ; metaphor ; neoliberal imagination ; older adults’ media practices ; older adults’ media biographies ; long-term care ; social isolation in later life ; social agency ; person-centered care ; information and communication technology (ICT) ; life course perspective ; communicative ecology mapping ; focused ethnography ; activism ; Iaioflautas ; intergenerational solidarity ; politicization ; social movements ; culture ; interdependence ; older immigrants ; religious minority ; social relationships ; older people ; public participation ; European welfare states ; gerontological responses ; pandemic management ; materiality ; corporeality ; humanoid robot Pepper ; human–robot interactions ; gender ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography
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  • 191
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: This Special Issue includes 12 articles, consisting of original research, narrative reviews, systematic reviews, and an editorial regarding the roles of dietary and lifestyle factors in the prevention and mangement of noncommunicable diseases. Studies in this Special Issue cover a range of topics including dietary patterns and diseases risk and prevention, the association of lifestyle factors and disease risk, the role of vitamin D and solar radiation in health and pregnancy, and urbanization in modifying risk of adverse health outcomes for various noncommunicable diseases.
    Keywords: dietary patterns ; physical activity ; noncommunicable diseases ; human health ; COVID-19 ; pregnancy ; bic Book Industry Communication::M Medicine
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  • 192
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: The COVID-19 pandemic caused a change in the pattern of various infectious diseases. Evidence suggests that the same nonpharmaceutical interventions employed to prevent the transmission of SARS-CoV-2 likely led to the reduced incidence of influenza in various regions across the globe. However, the COVID-19 pandemic caused disruptions in the reporting of other infectious diseases such as sexually transmitted diseases and other coronavirus infections. Decreased reporting of notifiable infectious diseases and conditions during the pandemic remained a major concern for health authorities. Ascertaining the impact of the COVID-19 pandemic on the transmission patterns of other infectious diseases holds significant implications for public health, but this topic has not yet been studied to a greater extent. On the other hand, the scope and relevance of clinical microbiology are appreciated more than ever. Viral structure, transmission, diagnosis, and optimal sterilization and disinfection process were the key elements that clinical microbiologists shared for the betterment of the community throughout the pandemic. This issue underscores various aspects of the advancements in infectious diseases and clinical microbiology during the ongoing COVID-19 pandemic. This Special Issue highlights the need for integrated efforts to control any future outbreak along with parallel management of other infectious diseases.
    Keywords: n/a ; COVID-19 ; antibiotic therapy ; mortality ; female gender ; neoplasm history ; heart failure ; diabetes mellitus ; aspirin ; elderly population ; low molecular weight heparin ; pulmonary thromboembolism ; hospital stay ; parental knowledge ; HPV infection ; HPV vaccine ; children ; adolescents ; NSAID ; duration ; side effects ; safety ; vaccine hesitancy ; comorbidities ; hypertension ; hyperlipidemia ; pharmacovigilance ; SARS-CoV-2 ; sequencing ; Nanopore ; MinION ; Ion Torrent ; mediterranean diet ; inflammatory factors ; stress oxidative ; appetite ; antiviral ; clinical outcome ; coronavirus ; disease severity ; Saudi Arabia ; vaccine ; knowledge ; attitude ; perception ; survey ; questionnaire ; breakthrough infections ; neutralizing antibodies (NAbs) ; Omicron ; vaccines ; variants ; latent tuberculosis infection ; hemodialysis ; QuantiFERON-TB Gold Plus assay ; Lebanon ; dexamethasone ; tocilizumab ; epidural abscess ; bacteremia ; inflammatory markers ; therapeutic plasma exchange ; plasmapheresis ; monkeypox outbreak ; public health ; emergency ; Peru ; coinfections ; antimicrobials ; Colombia ; epidemiology ; superinfections ; telemedicine ; primary practice ; ophthalmological diseases ; HIV infection ; CMV retinitis ; tuberculosis verrucosa cutis (TBVC) ; multifocal ; infectious diseases ; tuberculosis ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
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  • 193
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: In the age of neural networks and the Internet of Things (IoT), the search for new neural network architectures capable of operating on devices with limited computing power and small memory size is becoming an urgent agenda. This reprint focuses on recent developments in the organization of artificial intelligence (AI) on edge devices for various IoT-enabled smart applications and starts with the illustration of achievements in smart healthcare services. Digitalization of healthcare driven by the IoT and AI leads to the effective use of sensors, enabling various parameters of the human body to be instantly tracked and processed in daily life. The concept of machine learning sensors is applied to the diagnosis of COVID-19 as an IoT application in healthcare and ambient assisted living. Wearable sensors and IoT-enabled technologies also look promising for monitoring motor activity and gait in Parkinson's disease patients. IoT devices with AI can be effectively used in speech recognition and environmental monitoring, for detecting distracting actions in driver activities and for lifesaving applications such as child drowning prevention systems. Smart disaster rescue is an interesting development of a wearable device for search dogs that recognizes the behavior of a dog when a victim is found, using deep learning models. This reprint illustrates advanced cases of using AI technology for IoT-enabled smart applications.
    Keywords: deep learning ; canine activity recognition ; bark detection ; wearable computing ; search and rescue system ; stacking ; ensemble learning ; distracted driving ; imaginary speech ; convolutional neural network ; electroencephalography ; signal processing ; Kara One database ; COVID-19 ; biochemical and hematological biomarkers ; routine blood values ; feature selection method ; LogNNet neural network ; Internet of Medical Things ; IoT ; 5G and beyond ; child drowning prevention ; network slicing architecture ; point clouds ; remote sensing ; machine learning sensors ; inertial measurement unit ; smartphone ; accelerometry ; TUG test ; gait ; Parkinson’s disease ; “dry” immersion ; arrhythmia ; artificial intelligence (AI) ; cardiac ; communication technologies ; Electrocardiogram (ECG) ; systematic literature review (SLR) ; chemical carcinogens ; machine learning ; deep learning neural network ; hybrid neural network ; convolution neural network ; fast forward neural network ; edge computing ; ANN ; microprocessor ; water level prediction ; decentralized ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 194
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: Tackling inequalities in health and healthcare is more important than ever. The COVID-19 pandemic starkly illustrated the disproportional impact of the virus on those who already faced disadvantage and discrimination. Moreover, there is evidence that the public health measures taken to contain the virus are likely to have longstanding differential impacts across populations. Numerous studies have documented avoidable differences in health, within and between populations. Similarly, studies have consistently shown inequalities in access, use, experience and outcomes from healthcare and public health programmes. The focus has often been on individual determinants, such as gender, age and ethnicity. Less attention has been paid to structural or contextual determinants, except for area-level socioeconomic conditions. In addition, to tackle inequalities, there is a need to move beyond measuring; to understand why inequalities arise and how they can be addressed. This Special Issue sought to extend the parameters of inequalities research in health and healthcare beyond measuring and documenting inequalities. Reviews, observational studies, and quasi-experimental and other evaluation designs (using quantitative, qualitative or mixed methods), focusing on the following were welcomed: • understanding inequalities across health and care systems; • methodological developments to understand drivers of inequalities; • efforts to reduce inequalities, particularly in evidence-based healthcare or public health policy and practice; • understanding and mitigating the adverse impact of the COVID-19 pandemic on inequalities.
    Keywords: COVID-19 ; health inequalities ; general practice ; primary care ; social determinants of health ; social prescribing ; remote consulting ; marginalised communities ; health care inequalities ; health/healthcare inequity ; child development ; childhood education ; school ; adolescent health ; health inequality ; adolescent mental health ; adolescent weight ; health literacy ; organization and administration ; health care settings ; organizational innovation ; culture ; program development ; ethnic inequalities ; healthcare use ; care quality ; multiple long-term conditions ; UK ; mental disorders ; healthcare disparities ; primary health care ; systematic review ; PROGRESS-Plus ; social inequalities ; young people ; qualitative ; multimorbidity ; comorbidity ; housing ; household tenure ; data linkage ; population health management ; population health ; inequalities ; inequities ; process evaluation ; protocol ; early life health ; core outcome set ; public health interventions ; systems approach ; intervention ; workplace ; occupational stress ; older workers ; inequality ; health equity ; health services ; virtual care ; scoping review ; HIV ; chronic kidney disease ; Central and Eastern Europe ; serious injury ; traumatic brain injury ; orthopaedic injury ; spinal cord injury ; road trauma ; access to healthcare ; healthcare utilisation ; geography ; health disparities ; data quality ; public health ; head and neck cancer ; routes to diagnosis ; socio-demographic inequalities ; healthcare inequalities ; emergency presentation ; refugee ; asylum seeker ; health access ; health information ; women ; violence ; Australia ; Aboriginal and Torres Strait Islander ; care systems ; population groups ; risk behavior ; perceived tobacco use norms ; ethnic groups ; academic achievement ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
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  • 195
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint provides important scientific information across all areas of respiratory research including COVID-19, COPD, asthma, pulmonary embolism, pneumonia, sleep medicine and respiratory critical care.
    Keywords: SARS-CoV-2 ; transmission ; masks ; medical masks ; FFP masks ; N95 masks ; cloth masks ; respiratory side effects ; cough ; dyspnea ; sputum ; COVID-19 ; β-Thalassemia ; mortality ; critical care ; pandemic ; biomarkers ; chronic obstructive pulmonary disease ; exacerbations ; lung aging ; oxidative stress ; sleep deprivation ; exercise ; cardiovascular ; cognitive ; vitamin D ; hospitalization ; ICU admission ; intubation ; mechanical ventilation ; acute respiratory distress syndrome ; open lung biopsy ; histology ; diffuse alveolar damage ; pulmonary fibrosis ; idiopathic pulmonary fibrosis ; outcomes ; COPD ; respiratory muscle training ; cognitive impairment ; inspiratory muscle training ; expiratory muscle training ; FEV1 ; diaphragmatic thickness fraction ; mandibular advancement devices (MADs) ; obstructive sleep apnea (OSA) ; dental effects ; skeletal effects ; adults ; influenza ; human ; troponin ; cardiovascular infections ; virus diseases ; usTnT ; tuberculosis ; antituberculotic drugs ; host immune response ; pulmonary rehabilitation ; breakthrough COVID-19 hospitalizations ; clinical outcomes ; SARS-CoV-2 IgG Spike responses ; vaccine-induced immunity ; recovery ; septic shock ; venous return ; mean circulatory filling pressure ; stressed volume ; unstressed volume ; rest volume ; cardiovascular dynamics ; hemodynamics ; anesthesiology ; intensive care medicine ; latent tuberculosis ; inflammatory rheumatoid disease ; interferon-inducible protein-10 ; one-lung ventilation ; supine position ; iloprost ; oxygenation ; lung mechanics ; pulmonary embolism ; venous thromboembolism ; bleeding complications ; anticoagulant treatment ; prediction of bleeding ; in-hospital bleeding ; vaccination ; risk factors ; effectiveness ; fractional exhaled NO ; sevoflurane ; propofol ; eosinophil blood count ; thyroidectomy ; asthma ; sarcopenia ; low muscle mass ; inflammation ; respiratory disease ; diagnosis ; D-dimers ; ischemia modified albumin ; microparticles ; microRNAs ; Factor VIII ; C-reactive protein (CRP) ; community-acquired pneumonia (CAP) ; prognosis ; length of stay ; antibody ; infection ; immunization ; digitalization of healthcare ; control ; severity ; urokinase plasminogen activator receptor ; PM2.5 ; air pollution ; respiratory diseases ; pneumonia ; upper respiratory infections ; emergency department ; n/a ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: By joining the two previous editions, this Special Issue completes the trilogy of Special Issues entitled "Biological and Pharmacological Activity of Plant Natural Compounds", which deal with the properties and effects of phytonatural products in preclinical models. This third edition has also remained focused on their therapeutic potential, with the aim of increasing and contributing to the expansion of our scientific knowledge on plants in human health. We hope readers will enjoy this Special Issue as much as the previous publications.
    Keywords: seaweed ; extraction ; vitamin B12 ; central composite design ; curcumin ; antioxidant properties ; ozone ; Ammodaucus leucotrichus ; proximate analysis ; mineral element analysis ; decoction ; alcoholic extract ; essential oil ; secondary metabolites ; ammolactone-A ; R-perillaldehyde ; chemical characterization ; seaweeds ; marine algae ; marine drugs ; fucoidan ; sulfated polysaccharide ; cancer ; adjuvant ; prebiotics ; Candida albicans ; Lavandula angustifolia ; fluconazole ; caspofungin ; time-kill curve ; antioxidative activity ; antimicrobial activity ; Thai edible plant ; microwave-assisted extraction ; ultrasonic-assisted extraction ; quercetin ; antioxidant ; toxipathy ; diabetes mellitus ; advanced glycation end products (AGEs) ; protein cross link formation ; Punica granatum peel ; methylglyoxal ; apocarotenoid ; abiotic stress ; β-carotene ; gene expression ; herb–drug interactions ; Andrographis paniculata ; andrographolide ; glipizide ; superoxide dismutase ; isoflavones ; ion mobility-mass spectrometry ; amyotrophic lateral sclerosis ; aggregation ; bacterial resistance ; combination therapy ; COVID-19 ; medicinal plants ; new drugs ; synergism ; G. tenax ; GC-MS ; anti-spasmodic ; Ca2++ channel blockers ; phosphodiesterase ; artichoke bud ; synchronous extraction ; aqueous two-phase system ; dual-response surface model ; antioxidant activity ; carbohydrates ; polyphenols ; Carica papaya ; in silico ; cytotoxicity ; ethanol extract ; sepsis ; almond [Prunus dulcis (Mill.) DA Webb] hull ; extract ; triterpenoid acids ; hydroxycinnamic acids ; Ajuga integrifolia ; binding energies ; flavonoids ; phenolic acids ; shigellosis ; nephrotoxicity ; cisplatin ; diosmin ; lipid peroxidation ; inflammatory cytokines ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint, guest edited by Anne-Marie Caminade, gives an impressionist overview of the current state of the art about “Personalized and Precision Medicine”. Twenty contributions illustrate the diversity of the topic, including new approaches about cancers, neurodegenerative diseases, infectious diseases, lungs obstruction, skeletal diseases, intestinal microbiomes, new tools such as ultra-high-frequency ultrasound or non-oncological radiotherapy, and a new class of drugs (dendrimers). This reprint is an illustration of the present and future impact of Personalized and Precision Medicine on all the therapeutic domains.
    Keywords: cancer treatment ; immune checkpoint blockade ; PD-(L)1 inhibitors ; interorganizational transaction ; combination therapy ; bacteremia ; carbapenemase ; carbapenem-resistant Enterobacteriaceae ; Klebsiella pneumoniae ; mortality ; risk factors ; bone-anchored maxillary protraction ; skeletal class III malocclusion ; 3D printing ; growth modification ; cancer ; mucormycosis ; COVID-19 ; COVID-associated mucormycosis ; diabetes ; steroids ; immunosuppression ; dendrimers ; clinical trials ; phases 1, 2, and 3 ; polylysine ; polyamidoamine ; TPMT genotype ; TPMT poor metabolizers ; TPMT intermediate metabolizers ; AZA ; hepatotoxicity ; cumulative incidence of hepatotoxicity ; pharmacogenomics ; autoimmune disease ; preemptive genotyping ; TPMI ; black elderberry ; polyphenols ; prebiotic ; microbiota ; heart rate variability ; autonomic nervous system ; sleep ; obstructive sleep apnea ; radiotherapy ; non-malignant disorders ; non-oncological radiotherapy ; electromyography ; kinematic ; kinetic ; low back pain ; lumbar belt ; sit-to-stand ; chronic obstructive pulmonary disease ; overlap syndrome ; vitamin D ; ultrasound ; ultra-high frequency ; musculoskeletal ; imaging ; urinary bladder neoplasms ; neoadjuvant therapy ; cystectomy ; clinical decision rules ; prognosis ; multiple sclerosis ; personalized medicine ; autoimmune ; comorbidities ; hallmarks of cancer ; differential interactome ; system biomarkers ; druggability ; personalized treatments ; total knee arthroplasty ; fast track rehabilitation ; inpatient rehabilitation ; postoperative rehabilitation ; patient reported outcome measures ; Huntington’s disease ; psychosocial effects ; underserved region ; disease burden ; genetic counselling ; genetic testing ; complications ; low-molecular-weight heparin ; thromboembolism ; cerebral palsy ; muscle spasticity ; primary cell culture ; satellite cells ; skeletal muscle ; muscle ; skeletal ; humans ; epigenomics ; DNA methylation ; regulatory non-coding RNAs ; Alzheimer’s disease ; logopenic variant primary progressive aphasia ; empathy ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: The reprint “Sustainable Healthy Working Life for All Ages—Work Environment, Age Management and Employability” provide an outlet of research contributing to the development of theoretical and practical knowledge influencing people’s working life. Working life is complex and there are many different factors that influence, such as the demographic change, pandemic and rapid technological development, etc., which place constantly changing demands on both employees, organizations/companies and society in different countries. This reprint covers new knowledge, as identified factors and areas that affect employees' ability to work to an older age, interventions and measures that enable a healthy and sustainable working life throughout the entire working life journey, from young to senior employees. The reprint also addresses the pressured work situation of school leaders in managing the education of children and young people in society, and what makes them stay or leave their jobs. In addition, the reprint addresses the way in which the Covid-19 pandemic has affected working life, not least for the health care professional groups and organizations.
    Keywords: work resources ; work ability ; forest industry ; timber harvesting ; restructuring ; COVID-19 ; coronavirus ; COVID-19 phobia ; school administrator ; work–family conflict ; family–work conflict ; life satisfaction ; lifestyle health ; stratified consumption structure ; self-rated health ; regional differences ; intergenerational program ; swAge ; social capital ; trust in colleagues ; employability ; ageing ; work environment ; swAge-model ; demography ; retirement ; work–life balance ; discrimination ; competence ; older worker ; senior worker ; extended working life ; age management ; sustainable work ; employment ; well-being ; older workers ; aging ; person-centred ; organization ; nurse ; abuse ; long-term care ; wellbeing ; workforce ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Social good is typically defined as an actions and services that benefit the general public. In this case, internet connection, education, and healthcare are all good examples of social goods. However, new media innovations and the explosion of online communities have added new meaning to the term. Social good is now about global citizens uniting to unlock the potential of individuals, technology, and collaboration to create a positive societal impact.
    Keywords: online education ; learning analytics ; emergency remote teaching ; responsive dashboard ; eLearning and digital transformation of education ; IT for education ; automated transportation network ; collision-free routing ; grid network ; optimization algorithm ; integer linear programming ; heuristics ; Smart Campus ; smart waste management ; waste classification ; multi access edge computing ; Digital Twin ; big data ; geographic information system ; smart city ; Urban Facility Management ; Apache Spark ; ambient intelligence ; smart home in a box ; architecture ; framework ; digital libraries ; minority languages ; humanistic informatics ; computer archiving ; intercultural communication ; wearable computing ; interaction design ; neck-mounted interface ; flex sensor ; machine learning (ML) ; multi-person detection ; sensor data ; smart environment ; distributed ledger technology ; decentralized file storage ; distributed hash table ; data marketplace ; keyword-based search ; citizen-generated data ; COVID-19 ; contact awareness ; spatiotemporal analytics ; indoor positioning ; pedestrian dead reckoning ; landmark identification ; human-computer interaction ; virtual reality ; serious game ; interpersonal communications ; uncertainty ; social well-being ; behavioral responses ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: This collection that is based on the Special Issue contains 37 high-quality, rigorously peer-reviewed, cutting-edge pieces of original research applying a multi-disciplinary academic approach to study how to improve environment quality and healthy living in contemporary and future urban environments. This multidisciplinary collection helps to disseminate and communicate scientific knowledge and impactful discoveries of how to make healthy cities available to researchers, academics, and the general public globally.
    Keywords: urban sprawl ; physical health ; mental health ; Smog Free Tower ; air purification ; housing price ; moderating effect ; traffic convenience ; urban resilience ; spatiotemporal differentiation ; ESDA ; geographical detector model ; YRB ; social capital ; social participation ; volunteering ; urban China ; urban governance ; Chinese national scenic areas ; tourism economy ; time-limited rectification ; pilot free trade zones ; green total factor productivity ; green development ; difference-in-differences ; quasi-natural experiment ; land use evolution ; land ecological security ; AHP-FCE model ; evaluation ; China ; business environment ; FDI ; BRI countries ; status elevation the global value chain ; pilot free trade zone ; port ; green TFP ; environmental constraints ; regional heterogeneity ; air pollution ; health shocks ; labor mobility ; mediating effect ; threshold effect ; production-living-ecology ; spatial transformation characteristics ; spatial conflicts ; urban agglomeration ; carbon emissions ; Tapio decoupling ; LMDI model ; provincial level ; low-carbon economy ; physical inactivity ; prolonged sitting ; unhealthy diet ; sports facilities ; street greenery ; spatial accessibility ; medical system ; multi-tiered two-step floating catchment area (MT2SFCA) method ; equity ; healthcare ; Hu Line of land ; “production-living-ecology” coordination ; spatial heterogeneity ; ESDA-GWR ; COVID-19 ; mask ; willingness to pay ; protection motivation theory ; contingent value method ; urban ; health impact assessment ; bibliometric analysis ; CiteSpace ; knowledge mapping ; disaster-preventive migration (DPM) ; social stability risk ; fuzzy comprehensive evaluation (FCE) ; ethnic minority area ; green finance ; ecological environment ; coupling coordination rate ; spatiotemporal evolution ; driving factor ; environmental equality ; guanxi network ; pig farming pollution ; cost and benefit sharing ; technological innovation ; coupling coordination ; green economy ; aging migration ; housing tenure ; social integration ; Beijing ; environmental pollution control investment efficiency ; three-stage DEA ; super-efficient SBM ; Global-Malmquist-Luenberger index ; regional differences ; digital financial inclusion ; green innovation ; financing constraints ; life cycle ; carbon emissions trading ; total factor productivity of agricultural enterprises ; double difference ; policy mix ; policy design ; pandemic management ; policy outcomes ; compound crisis ; urban sustainability ; healthy cities ; projects ; risks ; expert evaluation ; fuzzy sets ; European Green Deal ; Industry 5.0 ; decision-making ; transport ; medical infrastructure ; healing and therapeutic design ; blockchain ; building information modeling (BIM) ; landscape information modeling (LIM) ; city information modeling (CIM) ; art therapy ; sustainable development ; non-fungible token (NFT) ; Health Metaverse ; workplace ; avoidance behavior ; public health ; regression discontinuity design ; migration intention ; high human capital ; instrumental variable ; regional economic resilience ; influence mechanism ; Yellow River Basin ; quality of life ; healthy region ; healthy environment ; spatial ; synthetic measure ; voivodship ; national fitness policy ; national health ; human capital ; public finance health expenditures ; civil registration ; block chain ; digitization governance ; smart contract ; urban young returnees ; happiness ; healthy China ; HLM ; SEM ; rural-to-urban migrant ; performance analysis ; science mapping ; network analysis ; environmental policy uncertainty ; enterprise pollution emission ; enterprise innovation ; the foreign investment ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
    Language: English
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