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  • Saccharomyces cerevisiae
  • gene expression
  • Springer  (438)
  • Wiley-Blackwell  (328)
  • MDPI - Multidisciplinary Digital Publishing Institute  (130)
  • 2020-2024  (130)
  • 1990-1994  (766)
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-08-08
    Beschreibung: The World Health Organization recommends the consumption of plant foods instead of animal-origin foods due to their high levels of saturated fat and cholesterol. Consumption of plant products has led to research on the beneficial properties of their components beyond basic nutrients. Vegetable-derived peptides have shown multifunctional effects related to chronic diseases, attracting interest from the food, nutraceutical, and pharmaceutical industries. This reprint highlights studies on various vegetable extracts, such as chestnut, quinoa, amaranth, buckwheat, and Protium heptaphyllum gum resin, which have demonstrated antimicrobial, anti-inflammatory, and cholesterol-regulating properties. Specific compounds derived from plants, such as methyl p-coumarate and lupin protein hydrolysate, have shown effectiveness in reducing inflammation and anxiety, respectively. A vegetable extract of rosemary has been studied for its potential to treat osteogenesis imperfecta. Moreover, this repprint reviews Lycium barbarum berries, essential oils from Annonaceae species, antioxidant compounds, phytosterols, and natural compounds for the prevention and treatment of oral mucositis was discussed. Overall, these studies suggest that vegetable-derived bioactive compounds could serve as new nutraceuticals to prevent and treat a wide range of chronic diseases.
    Schlagwort(e): hypercholesterolemia ; gene expression ; HMGCR ; PCSK9 ; PPARα ; enzymatic activity ; molecular docking ; statin ; monacolin ; breu branco ; seed storage proteins ; peptides ; anti-inflammatory ; antioxidant ; trypsin inhibitors ; quinoa ; amaranth ; buckwheat ; in vitro gastro-intestinal digestion ; natural products ; Brazilian species ; essential oil ; applications ; phytosterols ; neurodegeneration ; Alzheimer’s disease ; blood brain barrier ; obesity ; oxidative stress ; dyslipidemia ; diabetes ; enzyme-assisted extraction ; plant material ; phenolic compounds ; oligosaccharides ; prebiotic ; nanocellulose ; nanofibers ; fermentation ; sustainability ; cancer ; drug delivery ; oral mucositis ; treatment ; lupin ; protein hydrolysates ; anxiety ; ApoE−/− ; functional foods ; peptidomics ; rosemary extract ; collagen type I ; unfolded protein response ; autophagy ; proteasome ; skin fibroblasts ; apoptosis ; osteogenesis imperfecta ; asthma ; methyl p-coumarate ; Th2 cytokines ; eosinophil ; NF-κB ; Castanea sativa shells ; Subcritical Water Extraction (SWE) ; antimicrobial activity ; goji berries ; pro-healthy effects ; phenolics ; biological properties ; functional ingredients ; in vitro cultures ; Ruta montana ; coumarins ; alkaloids ; antibiofilm formation ; antibacterial activity ; antioxidant activity ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors
    Schlagwort(e): QH301-705.5 ; Q1-390 ; DNMTs ; n/a ; histone modification ; TBRS ; DNA methyltransferases ; autoinhibition ; epigenetics ; DNMT ; cell identity ; embryogenesis ; dwarfism ; DNMT3B ; germ cells ; HSAN1E ; USP7 ; DNMT3A ; DNA methyltransferase ; gene expression ; DNMT1 ; de novo DNA methylation ; DNA methyltransferase structure ; UHRF1 ; DNA methyltransferase mechanism ; allosteric regulation ; rare diseases ; DNA Methylation ; maintenance DNA methylation ; DNA methylation ; ADCA-DN ; PCC/PGL ; ubiquitination ; TETs ; DNA methyltransferase function ; molecular epigenetics ; DNA methyltransferase regulation ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-04-05
    Beschreibung: The eradication of vector-borne diseases is threatened by the limited range of available insecticides, leading, inevitably, to the development of resistance. This is particularly concerning for malaria control, which relies heavily on insecticide-treated nets (ITNs) and indoor residual sprays (IRS). New chemistries are being developed, and innovative deployment of insecticides may play a role in overcoming resistance, either through new types of tools or new means of distribution. A variety of novel product types and vector control strategies are under development and evaluation, which is to be celebrated, but a strong evidence base is needed to guide effective operational deployment decisions. Novel approaches should be supported by robust data collected using appropriate and validated methods to monitor efficacy, durability, and any emerging resistance. This reprint presents original research into developing and characterizing new vector control products, as well as understanding and monitoring insecticide resistance. Review articles explore the impact of insecticide resistance and offer guidance on insecticide choice in the face of pyrethroid resistance. Consensus methodologies are presented, in the form of standard operating procedures (SOPs) designed to be adopted and used to generate reproducible data that can be compared and interpreted across and between studies. It is hoped that this collection of articles offers inspiration and guidance on how consistent data can be generated to inform more effective development, evaluation, and use of new and existing vector control tools.
    Schlagwort(e): prallethrin ; insecticide ; spatial treatment ; mosquito fitness ; protection ; pyrethroids ; Aedes albopictus ; Culex pipiens ; life tables ; mosquito ; bite-proof garment ; model ; textile ; non-insecticidal ; physical barrier ; insecticide selection ; out-crossing ; strain authentication ; laboratory screening ; pyrethroid ; pyrethroid resistance ; insecticide resistance ; insecticide resistance management ; vector control ; malaria ; malaria control ; Anopheles ; host-seeking behavior ; insecticide exposure ; pathogen transmission ; Aedes aegypti ; Anopheles gambiae ; ATSB ; Culex quinquefasciatus ; Iroquois ; RNAi ; Saccharomyces cerevisiae ; yeast ; Anopheles mosquito ; fertility ; ovary development ; pyriproxyfen (PPF) ; side-effects ; machine learning ; image classification ; automated identification ; convolutional neural network ; insecticide-treated net (ITN) ; PBO ITN ; synergist ITN ; dual-AI ITN ; insecticide resistance management (IRM) ; method validation ; durability monitoring ; bioinsecticide ; disease transmission ; insecticide-resistance ; mosquito-borne disease ; mosquito control ; natural compounds ; phytochemical ; malaria vector ; insecticide treated nets ; cytochrome P450s ; kdr ; cuticular resistance ; deltamethrin ; imidacloprid ; bifenthrin ; β-cyfluthrin ; etofenprox ; α-cypermethrin ; λ-cyhalothrin ; thiacloprid ; mosquitoes ; Attractive Toxic Sugar Bait (ATSB) ; Attractive Targeted Sugar Bait (ATSB) ; diagnostic bioassay ; resistance monitoring ; insecticide-treated nets (ITN) ; strain characterisation ; method development ; product evaluation ; quality control (QC) ; dual active ingredients (dual-AI) ; bioefficacy ; IRS ; application technology ; broflanilide ; clothianidin ; pirimiphos-methyl ; WHO tube ; WHO tunnel test ; ITNs ; interceptor ; interceptor G2 ; membrane ; human arm ; rabbit ; bioassay ; bio-efficacy ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-11
    Beschreibung: Food waste is becoming an important and growing concern at both local and global levels. According to the Food and Agriculture Organization of the United Nations (FAO), one-third of all food production is wasted globally, and in particular, 1.3 billion tons of food produced for human consumption is wasted per year, representing an economic loss of EUR 800 billion. The main foods wasted are represented by vegetables, fruits, meat, and fish. Considering the high availability and the composition of food waste, there is an increasing interest in their bio-valorization. Moreover, according to the global Sustainable Development Goals (SDGs 12 and 13), an appropriate waste management represents an essential prerequisite for the sustainable development.This reprint collects interesting manuscripts regarding innovative research focused on food waste valorization through fermentation processes for obtaining value-added products such as enzymes, feed additives, biofuels, animal feeds as well as other useful chemicals or products, food-grade pigments, and single-cell protein (SCP), enhancing food security and environmentally sustainable development.
    Schlagwort(e): industrial food waste ; valorization ; biorefinery ; bioenergy ; biobased materials ; promotion policy ; rice husk ; pyrolysis ; porous biochar ; pore property ; surface composition ; microbial red pigment ; Monascus purpureus ; simultaneous hydrolysis and fermentation ; sustainability ; whey ; RSM ; bioethanol ; yeast fermentation ; sugar beet molasses ; industrial by-product ; scale-up ; agricultural waste ; wastewater ; microbial fuel cell ; techno-economic ; commercialization ; life cycle assessment ; Neurospora intermedia ; bread ; process development ; cheese whey ; Aspergillus awamori ; β-galactosidase ; lactose hydrolysis ; Acetobacter xylinum ; bacterial cellulose ; biosurfactant ; bioemulsifier ; waste frying oil ; Bacillus cereus ; food additives ; cookie ; microalgae ; DHA ; lignocellulosic biomass ; organosolv fractionation ; liquid fraction ; solid pulp ; omega-3 fatty acids ; soap ; olives ; olive oil ; fermentation ; food waste ; fish waste ; citrus peel ; aquafeed ; Saccharomyces cerevisiae ; Lactobacillus reuteri ; whey product ; proteins ; ultrafiltration ; nanofiltration ; keratinocytes scratch assay ; mozzarella cheese manufacturing ; pressing residue ; grape ; apple ; silage ; animal production ; enzyme production ; polyphenols ; Juglans regia L. ; walnut green husk ; agricultural wastes ; soil conditions ; glucans ; pectins ; Aspergillus oryzae ; rice hull ; paper mill wastewater ; bioremediation ; amylase ; solid-state fermentation (SSF) ; goat feeding ; durian peel ; silage additives ; propionate ; methane mitigation ; nitrogen balance ; waste management ; biofuel production ; circular economy ; single cell protein ; value-added product ; food and feed production ; yeast ; probiotics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
    Sprache: Englisch
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-12-06
    Beschreibung: Vegetable crops provide valuable minerals and vitamins that are indispensible for human health. Scientists have been working on the genetics of vegetable crops, deciphering the molecular bases of agronomically important traits. These genetic bases and variations in vegetable traits will greatly facilitate vegetable genetic improvement. Therefore, the genes of and genetic research on vegetable crops are of great importance. This Special Issue is a collection of 13 important research papers addressing the genes, genetics, and breeding of major vegetable crops. In the present book, the authors described the genes and QTLs responsible for stress tolerance, disease resistance, vegetable yield, and quality. The 13 research papers cover germplasm enhancement and evaluation, QTL mapping, gene isolation, marker development, and gene expression as well as gene editing in a wide range of vegetable species, including broccoli, pepper, eggplant, onion, and Cucurbita species. Readers from all over the globe are expected to greatly benefit from this Special Issue collection regarding their own work and the goal of improving breeding efficiency with molecular breeding to generate environment-adaptive, high-yield, and high-quality vegetable crops with which to feed the global population of 9.7 billion in an extreme climate by 2050.
    Schlagwort(e): pepper ; Capsicum annuum ; Phytophthora capsici ; high-density genetic map ; QTL ; Capcicum annuum L. ; RNA-Seq ; nitrogen-use efficiency ; low-nitrogen tolerance ; CaHSP18.1a ; gene silencing ; transgenic Arabidopsis ; heat stress ; gene expression ; pumpkin ; simple sequence repeat (SSR) ; syntenic relationship ; cross-species markers ; population structure ; eggplant ; heat shock factor (Hsf) ; heat shock protein (Hsp) ; thermotolerance ; C. frutescens ; SSR ; germplasm ; genetic diversity ; CRISPR/Cas ; gene knockout ; genome editing ; germplasm resource ; precision editing ; regulatory framework ; trait improvement ; Brassica oleracea ; broccoli ; candidate gene ; anthocyanin ; allelochemicals ; VOCs properties ; VOCs action ; VOCs detection ; green agriculture ; progress ; genetic researches ; molecular breeding ; transcriptomics ; transcription factor ; heritability ; genetic advance ; multi-trait selection ; principal component analysis ; HRM ; molecular marker ; phylogenetic analysis ; RNA sequencing ; SCAR ; SNP ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::T Technology, engineering, agriculture
    Sprache: Englisch
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: In this book, the performance of homogeneous and heterogeneous catalysts applied in biomass processing was assessed, paying special attention to the main advantages and challenges related to their use. Indeed, these challenges are opportunities to develop new research lines that could be fruitful in the near future. Thus, different studies are included, dealing with diverse subjects, with one main goal in common: the improvement of different aspects related to biomass processing through the use of catalysts.
    Schlagwort(e): nanospheroids ; zinc-doped CaO ; natural triglycerides ; aminolysis ; heterogeneous catalyst ; recyclability ; catalyst ; sodium hydroxide ; fatty acid methyl ester ; central composite rotatable design ; operational conditions ; aerated irrigation ; soil enzyme activity ; soil microbial biomass ; soil respiration ; bio-derived phenol ; Ni-Cu-Co/Al2O3 ; in-situ hydrodeoxygenation ; cyclohexane ; hydrogenolysis ; biomass ; 5-hydroxymethylfurfural ; 2,5-furandicrboxylic acid ; aerobic oxidation ; metal catalysts ; acid catalysis ; biodiesel ; biofuel ; esterification ; fatty acid ; methanolysis ; molybdenum oxide ; transesterification ; vegetable oil ; fatty acid methyl esters ; 2-ethyl-1-hexanol ; 1-heptanol ; 4-methyl-2-pentanol ; viscosity ; flash and combustion points ; methyl oleate ; methyl ricinoleate ; cellulase ; cellulose ; paper sludge ; Saccharomyces cerevisiae ; synergism ; furfural ; carbon-supported catalyst ; xylose conversion ; iron ; heterogeneous catalysts ; thermoset polymer ; epoxy ; cellulose nanofiber ; curing characteristics ; thermal properties ; mechanical properties ; RSM ; numerical optimization ; keratinase ; feather ; Bacillus sp. ; amino acids ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-11
    Beschreibung: In recent decades, the environmental impact of organic pollutants, especially persistent and emerging organic pollutants, has attracted widespread attention, and related research has been rapidly developed. Organic pollutants represent a popular topic of research in the environmental field. Large amounts of organic pollutants, which are widely distributed in air, water, sediment, soil, and other environmental media, are created via industrial production and other human activities. A series of research projects have been carried out regarding the development of analytical methods for organic pollutants, the distribution of environmental media, environmental concentration, environmental fate, the exploration of new pollutants, and the non-target analysis of organic pollutants.
    Schlagwort(e): regulated e-waste recycling ; polybrominated diphenyl ethers (PBDEs) ; heavy metals ; environmental media ; vegetable ; risks ; cardiovascular diseases (CVDs) ; heart failure ; polycyclic aromatic hydrocarbons (PAHs) ; trace elements ; serum ; polyhaloaromatic compounds ; chemiluminescence ; analytical method ; Fenton system ; hydroxyl radicals ; bisphenol analogues ; zebrafish ; joint toxicity ; gene expression ; online monitoring ; diagnosis ; PCDD/F ; incineration ; feedback control ; volatile organic compounds (VOCs) ; reference materials (RMs) ; quality control (QC) ; water analysis ; resin ; adsorption ; pore size distribution ; chemical modification ; water treatment ; PCNs ; spatial distribution ; congener ; environmental risk ; sediment ; VOCs ; distribution ; risk assessment ; chemical industrial park ; phthalate ; dietary intake ; DEHP ; DBP ; DIBP ; bottled drink ; PFASs ; QSAR–ICE–SSD ; electroplating industry ; ecological risk assessment ; PAHs ; historical trends ; shallow lake ; economic parameters ; sources ; sediment core ; gas chromatography-mass spectrometry ; HBCD ; EPS ; XPS ; POPs ; tetrabromobisphenol A ; Xenopus laevis ; brain development ; thyroid hormone ; biphasic concentration-response ; composting ; turning frequency ; ammonia oxidizing bacterial ; ammonia oxidizing archaeal ; N fractions ; ammonia emission ; screening assay ; thibz gene ; multiwell plate ; biomass combustion ; CHP plant ; renewable energies ; emission ; organic pollutants ; bisphenol analogs ; oxidative stress ; dechlorane plus ; maternal blood ; sequential samples ; variation ; correlation ; bisphenol A ; emissions ; polypropylene ; bottom sediments ; environmental monitoring ; Odra River estuary ; organotin compounds ; trueness ; verification ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering
    Sprache: Englisch
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: Fruits and vegetables are important sources of nutrients, such as vitamins, minerals, and bioactive compounds, and provide many health benefits. However, due to non-optimal post-harvest management, large quantities of fresh or fresh-cut fruits and vegetables experience a decline in their quality and nutritional value before they reach the consumer. This Special Issue covers technologies for the harvesting, handling, and storage of vegetables, including storage strategies such as active packaging, edible coatings, the application of nanotechnology in the post-harvest of vegetable crops, and others, with the aim of improving the shelf-life of fresh and fresh-cut fruits and vegetables.
    Schlagwort(e): fresh walnut ; total phenols ; frozen storage ; fatty acid ; antioxidant enzyme ; fruit storage ; antioxidant capacity ; phenolic compounds ; gene expression ; Fragaria × ananassa Duch. ; Sabrosa ; ripening stage ; headspace solid phase microextraction (HS SPME GC/MS) ; HPLC-MS/MS principal component analysis ; fresh-cut cauliflower ; storage period ; calcium chloride ; temperature ; factor analysis ; quality ; table grapes ; optimal harvesting ; technological maturity ; phenolic maturity ; non-destructive tools ; Multiplex® 3 ; pectin-based coating ; quality attributes ; fresh-cut carrot ; respiratory activity ; carotenoids and phenolic compounds ; lemon byproduct ; antioxidant ; e-nose ; ATR-FTIR ; image analysis ; multivariate analysis ; Barhi dates ; Phoenix dactylifera ; chitosan ; orange peel ; olive cake ; coating ; scanning electron microscopy ; surface structure ; antifungal active packaging ; raspberry ; green tea extract ; rosemary extract ; citrus ; intelligent logistics ; modeling ; orange ; postharvest ; chilling injury ; storage ; melatonin ; 1-MCP ; oregano ; vacuum packaging ; Allium cepa ; Rhus coriaria ; refrigeration ; mango fruit ; melatonin treatment ; cold storage ; decay ; physiological and metabolic processes ; goji berries ; shelf-life ; postharvest quality ; sensorial attributes ; freshness ; active packaging ; cold plasma ; dipping ; E-nose ; high hydrostatic pressure ; innovative postharvest technologies ; pulsed electric field ; vacuum impregnation ; near-infrared spectroscopy ; Pleurotus eryngii ; king oyster mushroom ; quality influential factors ; preservation ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The survival of plants under stressful environments requires the study of the mechanisms that help in reversing the adverse impacts of reactive oxygen species (ROS) excessively generated under these conditions. Understanding the mechanisms helps in adopting strategies to induce such mechanisms for the better acclimation of plants. These ROS, if not scavenged, cause damage of cellular components, including lipids, proteins, nucleic acids, and metabolites, and, in extreme cases, even the death of cells in plants. Confronted with abiotic stress, there is an initial elevation in ROS that activates redox signaling to initiate defense in plants through the activation of antioxidant activity. The improvement in the capacity of antioxidant machinery is one of the essential strategies with which to develop tolerance and relieve the pressure of abiotic-stress-induced oxidative changes for the survival of plants. This reprint provides knowledge on the following aspects: Impact of abiotic stress factors and the response of antioxidant machinery to changing abiotic stress conditions, as well as strategies with which to strengthen antioxidant machinery for the survival of plants; Strategies to improve the tolerance mechanisms of plants against abiotic stress factors; Roles and the mechanisms of the plant signaling molecules/growth modifiers/mineral nutrients/hormones/other elicitors in relieving the impacts of abiotic stresses; The utilization of approaches such as genomics, metabolomics, transcriptomics, proteomics, ionomics, and nutiomics to strengthen antioxidant machinery and make plant life easier under abiotic stress conditions.
    Schlagwort(e): tomato ; photosynthesis ; root growth ; oxidative damage ; melatonin ; drought ; gene expression ; toxic metals/metalloid ; nanoparticles ; phytohormones ; phytoremediation ; reactive oxygen species ; antioxidant enzymes ; heavy metal stress ; ubiquitination ; protein degradation ; gas exchange features ; osmotic adjustment ; water deficiency ; water-use-efficiency ; antioxidant defense ; arabidopsis ; bioinformatic analysis ; SlBAG genes ; SlBAG9 ; Solanum lycopersicum ; antioxidants ; oxidative stress ; marker-free transgenic rice ; mature seed-derived calli ; pea DNA helicase 45 ; salinity stress tolerance ; ethylene response factor ; flooding stress ; metallothionein ; monodehydroascorbic acid reductase ; resistant cultivar ; respiratory burst oxidase ; sensitive cultivar ; biochemical metabolites ; plant growth ; stigmasterol ; wheat ; polyamine ; iron-deficiency ; transcriptomics ; BAG9 ; Hsps ; thermotolerance ; ethylene ; hydrogen sulfide ; nitric oxide ; rice ; Arabidopsis ; metabolome ; ROS ; rohitukine ; ascorbate peroxidase ; catalase ; hydrogen peroxide ; NADP dehydrogenases ; NADPH oxidase ; salt stress ; superoxide dismutase ; seed priming ; spermine ; chromium ; S1fa transcription factor ; cell wall ; yeast ; antioxidant enzyme ; heat stress ; betaine ; seed germination ; physiology ; biochemistry ; Hibiscus cannabinus ; physiological changes ; bioactive constituents ; antioxidant capacity ; bioactive molecules ; carotenoids ; flavonoids ; osmotic stress ; phenolic acids ; secondary metabolites ; exogenous spermidine ; lettuce ; transcriptome ; vanadium stress ; sweet potato ; antioxidant defense system ; stomatal traits ; antioxidant systems ; Cu stress ; leucine ; nitrogen metabolism ; peach ; polyamine uptake protein ; Put2 ; ascorbate ; Dittrichia ; glutathione ; thallium toxicity ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-12-21
    Beschreibung: Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with P for “polycystin”, and TRPV with V for “vanilloid”. Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in “Cells” summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.
    Schlagwort(e): R5-920 ; n/a ; transient receptor potential channels ; photochromic ligands ; elementary immunology ; Purkinje cell ; EPSC ; substance P ; chemicals ; organ toxicity ; lymphocytes ; HSP70 ; physiology ; bioavailable ; inflammatory bowel disease ; platelets ; pollutants ; yeast ; regulatory T cells ; kinase ; Saccharomyces cerevisiae ; manganese ; cerebellum ; TRP channel ; NHERF ; inflammation ; nanoHPLC-ESI MS/MS ; TRPM7 ; chemical probes ; TRPM8 ; dorsal column nuclei ; TRPV2 ; TRPV3 ; calcitonin gene-related peptide ; TRPV1 ; ion channels ; transient receptor potential ; 2D gel electrophoresis ; MALDI-TOF MS(/MS) ; TRPV4 ; overproduction ; sulfur mustard ; oxidative stress ; graft versus host disease ; menthol ; topical ; chemosensor ; AP18 ; calcium signalling ; mucosal epithelium ; cuneate nucleus ; production platform ; TRPC channels ; ulcerative colitis ; channel structure ; xerostomia ; neutrophils ; cardiovascular system ; TRPC5 ; TRPC6 ; TRPC3 ; TRPC4 ; calcium signaling ; protein purification ; adipose tissue ; transient receptor potential (TRP) channels ; sodium ; TH17 ; diacylglycerol ; hypersensitivity ; TRPY1 ; GABAB ; HEK293 ; thrombosis ; ion channel ; TRPC ; pathophysiology ; SMAD ; toxicology ; endothelium ; calcium ; proteomics ; TRPA1 ; salivary glands ; TRP channels ; lipid mediators ; sensors ; radiation ; TRPM4 channel ; human medulla oblongata ; mGluR1 ; small molecules ; TRPC3 pharmacology ; bic Book Industry Communication::M Medicine
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-11
    Beschreibung: Plant stress could be defined as any unfavorable condition or substance that can affect or block the metabolism, growth or development of a plant. The response of the plant may vary depending on the frequency and intensity of the stressor, as well as the developmental stage of the plant. Plants, throughout their life cycle, are exposed to a large number of conditions or stressors. Abiotic stress is stress caused by non-living agents. Depending on the nature of the causal agent, it can be divided into physical and chemical. Physical (actually, physical-chemical) stresses include water deficits, salinity (in its osmotic component), temperature extremes (heat, cold, freezing), excessive or insufficient irradiation, anaerobiosis caused by waterlogging or flooding, mechanical stress caused by wind or excessive soil compaction and stress induced by wounds or injuries. Chemical stress is caused by salinity (in its ionic or toxic component), by the lack of mineral elements and by environmental pollutants such as sulphur dioxide (SO2), nitrogen oxides (NOx), chlorofluorocarbon compounds (CFCs), ozone (O3) and metals. The abiotic stresses that most negatively affect growth and production are probably drought, salt stress and temperature stress (high and low temperatures), all of which are associated with climate change.
    Schlagwort(e): gene bank ; germination ; orthodox seeds ; priming ; reactive oxygen species ; deficit irrigation ; plant physiology ; ornamental plants ; water relations ; water-use efficiency ; abiotic stress ; climacteric fruit ; ethylene scavengers ; fruit quality ; potassium permanganate ; Prunus persica ; UV radiation ; climate change ; soilless agriculture ; blossom-end rot ; tipburn ; calcium deficiency ; basil ; heat stress ; metabolome ; transcriptome ; molecular mechanism ; antioxidase ; factor analysis ; ion homeostasis ; osmoregulatory substance ; salicylic acid ; salt stress ; Melia azedarach ; provenance ; water deficit ; physiology response ; comprehensive evaluation ; chilling stress ; phenolics ; momilactones ; gene expression ; biosynthesis ; ultra-performance liquid chromatography-electrospray ionization-mass spectrometry ; real-time quantitative polymerase chain reaction ; L-arginine ; phenological periods ; regulated deficit irrigation (RDI) ; root reserves ; yield ; brassicas ; hyperspectral reflectance ; imaging sensors ; plant phenotyping ; multicolor fluorescence imaging ; thermography ; vegetation index ; salt tolerance ; Triticum aestivum L. ; Triticum durum Desf. ; autophagy ; mitophagy ; PCD ; ROS ; electromagnetic field ; seed priming ; eustress ; seed aging ; phytohormones ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Mitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translation, and assembly of respiratory chain complexes) that all take place within the mitochondria. Several aspects of mtDNA expression have already been well characterized, but many more either are under debate or have yet to be discovered. Understanding the molecular processes occurring in mitochondria also has clinical relevance. Dysfunctions affecting these important metabolic ‘hubs’ are associated with a whole range of severe disorders, known as mitochondrial diseases. In recent years, significant progress has been made to understand the pathogenic mechanisms underlying mitochondrial dysfunction; however, to date, mitochondrial diseases are complex genetic disorders without any effective therapy. Current therapeutic strategies and clinical trials are aimed at mitigating clinical manifestations and slowing the disease progression to improve the quality of life of patients. The goal of the Special Issue ‘Mitochondria: from Physiology to Pathology’ published in Life (ISSN: 2075-1729) was to collect research and review articles covering the physiological and pathological aspects related to mtDNA maintenance and gene expression, mitochondrial biogenesis, protein import, organelle metabolism, and quality control.
    Schlagwort(e): atherosclerosis ; carotid intima-media thickness ; mitochondrial mutations ; cardiovascular risk factors ; mitochondria ; mtDNA ; cristae ; mitochondrial fission ; mitochondrial fusion ; mitochondrial diseas ; mitochondrial dynamics ; mitoenergetics ; mitosteroidogenesis ; LH ; cAMP ; Leydig cell ; mitochondrial DNA segregation ; heteroplasmy ; selective elimination ; mitophagy ; mitochondrial engineered nucleases ; kinases ; phosphorylation ; disease ; PINK1 ; Parkinson’s disease ; mitochondria homeostasis ; Cterm ; MELAS ; transmitochondrial cybrids ; aminoacyl-tRNA synthetases ; LARS2 ; mitochondrial disease ; therapeutic peptides ; FAD synthase ; FAD1 ; mitochondria localization ; Saccharomyces cerevisiae ; mRNA ; mitochondrial localization motif ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-24
    Beschreibung: Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests.The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first “site-agnostic” drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic “signatures” that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.
    Schlagwort(e): patient-derived tumor xenograft (PDX) ; anti-cancer drug development ; immunodeficient mice ; precision medicine ; molecular profiling ; immunohistochemistry ; next-generation sequencing ; targeted therapy ; molecular oncology ; biomarkers ; molecular imaging ; non-small cell lung cancer ; proliferation ; cancer stem cells ; circulating tumour cells ; personalised treatment ; renal cell carcinoma ; clear cell ; VEGF ; immunotherapy ; PD-L1 ; immune checkpoint inhibitors ; immune checkpoint blockade ; tyrosine-kinase inhibitors ; integrin-linked kinase (ILK) ; ovarian cancer ; sgRNA ; gene expression ; microarray ; xenograft ; MTB ; cancer ; oncology practice ; community setting ; CGP ; pancreatic cancer ; FOLFIRINOX ; chemotherapy ; gender ; cholangiocarcinoma ; biliary tract cancer ; prognosis ; neutrophils ; BRCA1 ; BRCA2 ; PALB2 ; homologous recombination repair ; colorectal cancer ; heme oxygenase-1 ; endothelin-1 ; endothelin con-verting enzyme-1 ; bosentan ; precision oncology ; tumor-agnostic indications ; solid tumors ; tumor markers ; FDA-approved therapeutics ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-02-02
    Beschreibung: Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories.
    Schlagwort(e): developmental origins of health and disease (DOHaD) ; gut microbiota ; hypertension ; short chain fatty acid ; oxidative stress ; probiotics ; prebiotics ; renin–angiotensin system ; fibroblast growth factor-23 ; left ventricular hypertrophy ; renin–angiotensin–aldosterone system ; losartan ; canrenone ; Hyp mice ; X-linked hypophosphatemia ; hairless SHRM ; cold acclimation ; cardiac Cx43 ; extracellular matrix ; thyroid hormones ; SHR ; sacubitril/valsartan ; ARNI ; ivabradine ; remodelling ; cardiac dysfunction ; fibrosis ; angiotensin II ; angiotensin 1-7 ; knock-out ; genome-editing ; SHRSP ; Dahl SS ; foetal programming of hypertension ; sympathetic neurotransmission ; sympathetic innervation ; vascular remodelling ; foetal undernutrition ; old SHR ; antihypertensive therapy ; blood pressure monitoring ; LV hypertrophy ; ECM markers ; cardiac fibrosis ; SHR-CRP ; SGLT-2 inhibitor ; gene expression ; age ; lipid metabolism ; nitric oxide ; l-NAME ; rostral ventrolateral medulla ; aging ; reactive oxygen species ; NADPH oxidase activator 1 ; mitochondria ; chloride ; calcium-activated chloride channel ; Na+–K+–2Cl− cotransporter 1 ; TMEM16A ; smooth muscle ; fetal undernutrition programming ; cross-fostering ; lactation period ; cardiovascular hypertrophy ; adipose tissue browning ; cardiovascular disease ; catecholamines ; liquid chromatography–tandem mass spectrometry ; SGLT-2 inhibition ; proteinuria ; uninephrectomized salt-loaded ; two-kidney ; one-clip hypertension ; fawn-hooded hypertensive rat ; ApoE KO ; apolipoprotein E knockout mice ; atherosclerosis ; Na,K-ATPase ; TCTP ; TCTP-overexpressing transgenic mice ; translationally controlled tumor protein ; TCTP-TG ; experimental hypertension ; bone ; rats ; taurine ; magnesium ; 24 h urine(24U) ; stroke-prone spontaneously hypertensive rat ; young SHR ; combination therapy ; treatment effect ; systolic blood pressure ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
    Sprache: Englisch
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: Tea, made from the leaves of the Camellia senenisis plant, is the second most consumed beverage worldwide after water. Accumulating evidence from cellular, animal, epidemiological and clinical studies have linked tea consumption to various health benefits, such as chemoprevention of cancers, chronic inflammation, heart and liver diseases, diabetes, neurodegenerative diseases, etc. Although such health benefits have not been consistently observed in some intervention trials, positive results from clinical trials have provided direct evidence supporting the cancer-protective effect of green tea. In addition, numerous mechanisms of action have been suggested to contribute to tea’s disease-preventive effects. Furthermore, effects of the processing and storage of tea, as well as additives on tea’s properties have been investigated.
    Schlagwort(e): QH301-705.5 ; Q1-390 ; TX341-641 ; polyphenols ; n/a ; cell cycle arrest and apoptosis ; neuroblastoma ; salivary ?-amylase activity ; cancer apoptosis ; yaupon holly ; bioaccessibility ; fracture ; p53 ; tea ; Liubao tea ; BE(2)-C ; matrix metalloproteinase-1 (MMP-1) ; catechin ; renal stone ; oxalate ; protein expression ; 67LR ; Alzheimer’s disease ; EGCG ; nutraceutical ; diseases ; anti-oxidant ; heme oxygenase-1 ; polyphenol ; anxiety ; matcha ; ERCC1/XPF ; neuro-sphere ; tea consumption ; theanine ; Rosmarinic acid ; yerba mate ; hypercalciuria ; gene expression ; microbiota ; cohort study ; histone deacetylase 2 (HDAC2) ; guayusa ; nuclear factor erythroid 2-related factor 2 (Nrf2) ; DNA repair ; mRNA expression ; caffeine ; chemoprevention ; cisplatin ; 6-OH-11-O-hydroxyphenanthrene ; adrenal hypertrophy ; hepatic damage ; anti-photoaging ; cell death ; green tea ; kudingcha ; suberoylanilide hydroxamic acid (SAHA) ; epigallocatechin gallate (EGCG) ; stress-reduction ; calcium oxalate monohydrate ; Camellia sinensis ; chemoresistance ; tea polyphenols ; green tea polyphenols ; green tea catechins ; N-MYC ; cancer ; epigallocatechin-gallate (EGCG) ; Parkinson’s disease ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The exposure of animals to environmental stresses (restraint, bad housing conditions, irradiation, pollution, diseases, and heat stress) and endogenous stresses (metabolic and physiological disorders) can seriously disrupt the redox homeostasis, leading to impairments in animals’ health and overall performance. Under these circumstances, the self-antioxidant defense system may not be enough to neutralize ROS effects. In this context, the utilization of an exogenous source of antioxidants, mainly dietary sources, may present an effective and cost-effective solution. There are a plethora of substances, either naturally occurring or synthesized (organic acids, minerals, vitamins, hormones, and specific feed additives originating from plants such as essential oils and polyphenols), known for their antioxidant activity, that can be used to maintain adequate redox status in animals in order to preserve their well-being and/or productivity. This area of research still needs more investigations in order to clearly elucidate the effective antioxidant substances that could be used in practical applications, with an emphasis on their biological mechanisms during different physiological conditions and health statuses. We intend to bring together current research concerning the role of antioxidant substances either from natural sources or those synthesized for improving animal production, reproduction, health, and welfare.
    Schlagwort(e): antinutrient ; enzyme ; fermentation ; fiber ; gut health ; microbiota ; meta-analysis ; poultry ; prebiotic ; antioxidants ; growth ; heat stress ; rabbit ; selenium ; spirulina ; zinc ; broiler ; dietary protein level ; phytogenic feed additive ; growth performance ; immune response ; exercise ; endurance ; undenatured type II collagen ; anti-inflammatory ; cardiac injury markers ; oxidative stress ; histopathology ; Bcl-2 ; Bax ; TGF-β1 ; date palm (pollen extract) ; doxorubicin ; nitrocompounds ; nitropropanol ; nitroethanol ; biochemical parameters ; oregano essential oil ; temperature ; sea bass ; cornelian cherry extract ; glucose transporter ; gene expression ; oxidative biomarker ; chicken ; cyclic heat stress ; Spirulina platensis ; redox status ; serum metabolites ; blood hematology ; meat quality ; fipronil ; boswellic acid ; PCNA ; semen ; fertility-related markers ; Oreochromis niloticus ; antioxidant ; hematology ; nitric oxide ; lysozyme ; copper toxicity ; vitamin C ; vitamin E ; hematological parameters ; phytogenic ; phenols ; antimicrobial activity ; immunity ; phenolic antioxidant ; olive oil ; caprine ; spermatozoa ; Bayesian inference ; Duroc breed boars ; biochemistry ; blood parameters ; feeding time ; correlation coefficients ; Turraea fischeri ; polyphenolics ; semen cryopreservation ; sperm ultrastructure ; antioxidant biomarker ; apoptosis ; nano particles ; performance ; blood ; pathogens ; quails ; carcass traits ; blood biochemical constituents ; abdominal fat color ; meat fatty acid profile ; liver histology ; broilers ; Eimeria tenella ; broiler chickens ; oocyst shedding ; volatile fatty acids ; feed efficiency ; cecal health ; active yeast ; antioxidant status ; nutrient density ; trace element ; laying hen performance ; high temperature ; inflammation ; cryopreservation ; tannin ; polyphenols ; semen additives ; carcass ; fructooligosaccharide ; haemato-biochemical parameters ; cecal microbiota ; propolis ; bee pollen ; productive performance ; fertility ; Holstein ; folic acid ; pregnancy ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSV Zoology and animal sciences
    Sprache: Englisch
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-08-08
    Beschreibung: The externalization of animals’ genetic potential is determined by a number of external factors, of which feeding plays a major role. Animals’ nourishment is one of the most important levers to ensure the efficiency of animal production due to both the high share of feed costs in the total cost of products and the influence this has on the growth, reproduction, and health of animals as well as the quality of products obtained from these. This field is one of the most dynamic in the field of husbandry sciences due to the takeover and permanent use of numerous results obtained from research on energy metabolism and nutrients related to the composition of feed and its influence on animal products. This is also due to the great advances in genetics, which create new types of animals with increasing productive potential, but also with different food requirements. This Special Issue collated innovative papers on animal nutrition, physiology, chemistry, biochemistry, genetics, reproduction, and breeding technologies. The articles covered a wide range of topics related to feed quality, the influence of food on the production level, the quality of production, and also on animals’ health.
    Schlagwort(e): carcass yield ; commercial cuts ; low cost ; neutral detergent fiber ; non-fiber carbohydrate ; Yucca schidigera ; antimicrobial ; secondary metabolites ; sustainability ; pollution ; production ; food animals ; Ajuga iva ; chemical composition ; nutritive value ; unconventional feeds ; phenolic ; growing conditions ; dairy buffaloes ; farming environment ; reproductive and productive performances ; feeding trial ; mozzarella cheese ; sensory properties ; alternative feed ; degradability ; fractions ; ram ; sperm quality ; Saccharomyces cerevisiae ; apparent digestibility ; honey ; quality ; phenolic content ; flavonoid content ; Pearson’s correlation ; female camels ; milk ; minerals ; heavy metals ; winter ; total mixed ration ; paddlefish ; meat quality ; fatty acids ; biological value ; body condition score ; ewes ; reproductive traits ; flushing ; animal production ; genetic diversity ; grey cattle ; mitochondrial DNA ; Podolian cattle ; European catfish ; somatometry ; corporal indice ; flesh yield ; nutritional quality ; lactation ; manganese ; reproductive performance ; sows ; AP monitoring ; IoT ; AP estimation ; decision support ; livestock farming ; polycyclic aromatic hydrocarbons ; meat ; chicken ; duck ; turkey ; phenols ; flavonoids ; FTIR ; rearing system ; birds’ welfare condition ; biochemical analysis ; productive parameters ; food and feed safety ; yeasts and molds ; Salmonella spp. ; Escherichia coli ; Clostridium perfringens ; rabbit ; hare ; lipid health indices ; water-holding capacity ; cooking loss ; egg weight ; shell weight ; fractional reduction ; deletion method ; reproduction ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Sprache: Englisch
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  • 18
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-05-11
    Beschreibung: It was recently reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. Human and industrial activities generate various forms of residual wastes and by-products in a solid, liquid, or gaseous state. Waste generation starts with simple processes such as living, eating, and breathing. Managing waste and minimizing associated environmental impacts have become more challenging as worldwide populations and economies continue to grow. Once these hazardous chemicals are present in the environment, people can become exposed to them. Human health can be influenced by many factors, including exposure to physical, chemical, biological, and radiological contaminants in the environment.This reprint comprises research papers related to the aspects of environmental exposure to multiple toxic chemicals and human health. The manuscripts are focused on toxicology, biomonitoring, exposure and risk assessment, and endocrine disruptors.
    Schlagwort(e): pesticide ; insecticide ; herbicide ; fungicide ; rheumatoid arthritis ; autoimmune disease ; n/a ; ovary ; endocrine disruptors ; follicular growth ; hormonal secretions ; gene expression ; bisphenols ; plasticiser ; ewe ; tetracyclines ; sulfonamides ; quinolones ; streptomycines ; meat ; antibiotics ; risk assessment ; air pollution ; endothelium ; inflammation ; cardiovascular disease ; ALS ; Alzheimer’s ; Aβ1–42 ; α synuclein ; children ; cerebrospinal fluid ; cisternal CSF ; fronto-temporal dementia ; Metropolitan Mexico City ; nanoparticles ; olfactory bulb granule cells ; PM2.5 ; Parkinson’s ; hyperphosphorylated tau ; TDP-43 ; cadmium ; crab ; crustaceans ; heavy metal toxicity ; nutrition ; pollution ; biomagnification ; biomonitoring ; benchmark dose ; BMDL ; BMDU ; creatinine clearance ; chronic kidney disease ; eGFR ; NOAEL ; urine cadmium ; plant protection products ; residential exposure ; agriculture ; Africa ; exposure pathway ; intake dose ; temporal variations ; spatial variations ; pollutants ; women exposure ; microRNAs ; PAHs ; paint production plant ; volatile organic compounds (VOCs) ; inhalation exposure ; cancer risk ; non-cancer risk ; economic loss ; subway PM exposure ; health burden ; long-term mortality ; morbidity ; 3-PBA ; pyrethroid pesticides ; pregnancy ; newborn ; anthropometry ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
    Sprache: Englisch
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-09-11
    Beschreibung: Plants under natural conditions often face multiple stresses, including drought, salinity, temperature extremes, submergence stress, bacteria, viruses, fungi, insects, etc. These biotic and abiotic stresses negatively influence plant growth and productivity. Various approaches have recently been used to overcome stresses in plants. It is necessary to evaluate and explore how diverse molecular techniques can be applied to different biological studies to improve biotic and abiotic stress tolerance in plants. This will help reduce production losses and increase crop tolerance to various stresses. It is now the time to make a difference by developing plants that can withstand biotic and abiotic stresses.
    Schlagwort(e): antioxidants ; drought ; oxidative stress ; pearl millet ; redox implications ; ROS ; chlorophyll fluorescence efficiency ; photosynthetic responses ; enzyme activity ; sugarcane ; smut ; circadian clock ; reactive oxygen species ; Al-induced PCD ; photoperiodism ; peanut ; phylogenetic ; virus-induced gene silencing ; transgenic lines ; physiological and biochemical analysis ; Glycine max L. ; PR proteins ; chitinase ; genome-wide ; plant stresses ; crop residues ; profitability ; soil fertility ; soil biology ; allelopathy ; heat shock protein 20 ; maize ; abiotic stress ; yeast-one-hybrid ; abiotic stresses ; cotton ; hormones ; signaling pathway ; WRKY ; papaya (Carica papaya) ; brassicales ; late embryogenesis abundant protein ; orthogroup ; expression profile ; artificial light ; auxins ; chicory ; callus cells ; inulin ; plant growth regulators ; milk thistle ; secondary metabolites ; ecotypes ; salinity ; growth attributes ; biotic stress ; phenolic compounds ; seaweed ; Dendrobium catenatum ; lipase ; multi-omics ; expression pattern ; gene family ; bio-fertilizer ; ionic homeostasis ; organic amendments ; vermicompost ; cold stress ; PKS5 ; stomatal aperture ; microbiota ; natural farming ; physical factors ; physiological changes ; signal transduction and stressed conditions ; Rhizobium leguminosarum ; PGPR ; Triticum aestivum L. ; cadmium stress ; tolerance ; ascorbate ; glutathione ; malondialdehyde ; chlorophylls ; disease gradient ; disease outbreak ; Puccinia ; wheat stripe rust ; plant epidemic ; dispersal ecology ; alternative plant vitrification solution ; ammonium-free medium ; cytotoxicity ; droplet-vitrification ; endangered species ; liquid overlay ; regrowth medium ; within-plant phenotypic plasticity ; combined stresses ; additive ; antagonistic and synergic effects ; VOCs ; potassium ; soybean ; water logging ; yield ; non-thermal plasma ; plant defense ; glucosinolates ; nitriles ; RNA sequencing ; Arabidopsis thaliana ; Bt toxins ; Cry1Ah1 transgenic poplar ; ecology ; environment ; rhizosphere ; candidate genes ; drought tolerance ; crop improvement ; climate change ; adaptation ; Chenopodium quinoa Willd. ; genotypes ; Sahara ; Algeria ; chitosan ; pathogen ; sustainable ; plant protection ; tomato ; melatonin ; photosynthesis ; climate changes ; antioxidant system ; Malus seedlings ; NaCl treatments ; membrane damage ; osmotic regulation ; archives ; botanical collection ; Greece ; landscape ; pre-rebellion period ; wheat ; priming ; Aspergillus niger ; qRT-PCR ; wilting ; TLP ; β-1,3-glucanase ; biostimulants ; biofertilizers ; soil microorganisms ; phytostimulator ; jewel sweet potato ; shoot tip ; axillary bud ; different MS salts concentration ; micropropagation ; plant performance ; C4 species ; heterozygosity ; transient soil salinity ; soil layers ; desertification ; arid regoins ; total flavonoid ; phenolics ; antioxidant activity ; centella ; Na+ content ; molecular markers ; MAS ; oilseeds ; SSRs ; molecular breeding ; dehydration-responsive element binding (DREB) transcription factors ; gene expression ; mosses ; stress tolerance ; common centaury ; salinity stress ; antioxidative protection ; sodium nitroprusside ; proteomic analysis ; drought stress ; sorghum ; RNS ; RSS ; signaling ; post-translational modification ; microorganisms ; stressful conditions ; sustainability ; nutrition ; Brassicaceae ; Cicer arietinum L. ; chlorophyll a fluorescence transient ; physiological and biochemical traits ; high temperature ; chocolate spot disease ; Botrytis fabae ; faba bean ; antioxidant enzymes ; protein banding and anatomy ; actinobacteria ; Streptomyces tuirus ; chilli fruit rot ; Colletotrichum scovillei ; Colletotrichum truncatum ; Fusarium oxysporum ; liquid bio-formulation ; corn smut ; fungus infection ; MDA ; proline ; quality ; halophytes ; Tripolium pannonicum ; hydrogen peroxide ; cell wall extensibility ; cell wall polysaccharide ; coleoptile ; growth inhibition ; lead (Pb) ; rice ; Bactrocera oleae ; spinosad ; kaolin ; organic oliviculture ; chlorophyll fluorescence ; leaf gas exchange ; physiological traits ; BAG (Bcl-2-associated anthanogene) family proteins ; molecular chaperone ; metabolomics ; metabolic responses ; metabolites variation ; surveillance ; Candidatus Liberibacter asiaticus ; comprehensive control ; distribution ; screen house ; Copper hyperaccumulation ; stress mitigation ; EDTA and IAA ; sunflower ; Fusarium wilt ; conventional breeding ; molecular makers ; QTLs ; genomics ; transcriptomics ; metabolomics and proteomics ; bread wheat ; AMF ; zinc ; growth parameters ; osmolyte ; osmoprotector ; ionic attributes ; PGPBs ; growth-promoting fungi ; crop productivity ; plant tolerance ; arbuscular mycorrhizal fungi ; aerobic rice ; soil enzymes ; phosphorus utilization ; P-deficient ; plant growth promotion ; chickpea ; selection indices ; drought tolerant genotypes ; abiotic and biotic stress ; CRISPR ; mega nucleases ; TALEN ; ZFN ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 20
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-11
    Beschreibung: This Special Issue of Life, entitled "Plants as a Promising Biofactory for Bioactive Compounds," showcases the latest research that explores the utilization of plant biofactories for the production of compounds with multiple biological effects, including antioxidant, antitumor, antidiabetic, anti-inflammatory, antimicrobial, anti-Alzheimer, antihemolytic, neuroprotective, and pesticide activities.
    Schlagwort(e): Arabidopsis ; hairy roots ; lipase ; protein production ; phenolic acid ; flavonoids ; DPPH radical scavenging activity ; anti-inflammatory activity ; maximum possible analgesia ; beverage preservative ; natural essential oils ; antimicrobial activity ; Lithospermum erythrorhizon ; acetylshikonin ; shikonin ; BAHD ; LeSAT1 ; hairy root ; Agathophora alopecuroides ; antidiabetic ; LC-HRMS/MS ; molecular docking ; waste ; by-product ; composition ; bioactive compounds ; health benefits ; blueberry ; Vaccinium myrtillus ; Vaccinium arctostaphylos ; phenolic compounds ; antioxidant activity ; neuroprotective activity ; naringin ; naringenin ; polyphenols ; neurological disease ; dietary interventions ; Cinnamomum zeylanicum ; polyphenol ; cinnamon oil ; LC-HRMS ; GCMS ; enzyme inhibition ; arbuscular mycorrhizal fungi ; commercial herb cultivation ; gene expression ; rosemary ; terpene synthase ; volatile production ; coronavirus ; COVID-19 ; antivirals ; vaccines ; plant production ; molecular farming ; recombinant proteins ; secondary metabolites ; ABTS ; DPPH ; early bud burst ; English oak ; half-sib ; late bud burst ; pedunculate oak ; total flavonoid content ; total phenol content ; natural products ; acetone:butanol:ethanol ; solvent extraction ; process design and economics ; Caenorhabditis elegans ; Meloidogyne incognita ; Zivzik pomegranate ; Punica granatum ; antioxidant ; α-glycosidase ; acetylcholinesterase ; carbonic anhydrase ; LC-MS/MS analysis ; antitumor activity ; cancer ; ethnobotany ; lymphoma ; medicinal plants ; natural extracts ; Mexican plants ; Andrographis ; antioxidants ; GS-MS analysis ; β-D-glucans ; cereals ; biosynthesis ; genes ; breeding ; environment ; functions ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
    Sprache: Englisch
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Plant growth-promoting microorganisms (PGPM) are groups of rhizosphere microorganisms capable of colonizing the root environment. Some of the microbes that inhabit this zone are bacteria and fungi that are capable of efficiently colonizing roots and rhizosphere soil. These microorganisms can be used as biofertilizers for improving agricultural production even under stressful environmental conditions. In contrast to PGPM, plant growth regulators (PGR) are chemical compounds that significantly affect the growth and differentiation of plant cells and tissues. They function as chemical messengers for intercellular communication and play a vital role in plant signaling networks as they are involved in the plant developmental process and a wide range of biotic and abiotic stress responses. The application of PGPM and plant growth regulators/hormones or the synthesis of PGR and signal transduction, perception, and cross-talk creates a complex network that plays an essential role in the regulation of plant physiological processes. A better understanding of the mechanism of action of PGPM and PGR and their roles in plant growth and development, interaction and independence in their action, and hormonal crosstalk under stresses is essential for agricultural production and research. Therefore, this book has contributions in the form of research and review papers from eminent scientists worldwide and discusses the role of PGPM and PGR in agriculture production and research, their potentials as biocontrol agents, their effects on physicochemical properties of soil, innovation for sustainable agriculture, their role in seed transplanting, and their role in mitigating biotic and abiotic stresses.
    Schlagwort(e): Paecilomyces ; PGPF ; tomato ; pepper ; plant probiotic microorganisms ; Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae) ; Solanum lycopersicum L. ; secondary metabolites ; plant insect interactions ; seaweed extract ; phytohormone profiling ; fertilizers ; antioxidant ; plant growth regulators ; brown seaweed ; green algae ; abiotic stresses ; cell membrane stability ; climate change ; osmolytes ; polyamines ; bacterial community composition ; liquid food waste materials (LFM) ; plant growth-promoting bacteria (PGPB) ; plant growth-promoting (PGP) traits ; salinity ; PGPR ; wheat ; compatible solutes ; antioxidant enzymes ; Trichoderma ; plant growth promotion ; biostimulant ; aridity ; Bacillus sp. ; biochar ; nutrient availability ; organic matter ; soil health ; mVOCs ; Plant growth promoting rhizobacteria ; Mentha piperita ; Bacillus amyloliquefaciens GB03 ; salt stress ; MDA ; DPPH ; Bradyrhizobium japonicum ; Pseudomonas putida ; plant growth ; plant nutrients ; soil enzymes ; soil nutrients ; soybean ; sweet pepper ; Bacillus ; chitosan ; chlorophyll fluorescence ; fruit yield ; plant growth promoting microorganisms ; abiotic stress ; biotic stress ; flavonoids ; biotic and abiotic stress ; symbiosis ; signaling ; rhizobium ; AMF ; allelopathy ; biocontrol Aspergillus japonicus ; root-knot nematode ; fermentation filtrate ; biological control ; seed germination ; α-Tocopherol ; antioxidants ; drought ; nutrient dynamics ; tissue specific response ; deep N fertilization ; peroxidase activity ; catalase activity ; rice cultivation ; ABA biosynthesis ; drought stress ; gene expression ; signaling network ; transporters ; Zea mays L. ; environmental stresses ; endophytic bacteria ; plant growth promoting ability ; chromium ; Staphylococcus aureus ; oxidative stress ; available phosphorus ; enriched compost ; poultry litter ; rock phosphate ; pear trees ; PGR ; sustainable development ; crop nutrition ; fertiliser ; Timac Agro Italia ; allelopathic bacteria ; antimetabolites ; phytotoxic metabolites ; rhizobacteria ; weed invasion ; anthocyanins ; color ; fruit size ; phenolics ; Punica granatum ; PGPMs (plant growth-promoting microorganisms) ; tee tree oil ; plant biostimulants ; soil-borne phytopathogens ; antagonistic fungi ; biocontrol ; biotic effect ; crop production ; RIDER ; drylands ; water conservation ; biomass reduction ; cereal crops ; growth regulators ; metal stress ; sugar beet ; nitrogen fertilizer ; gibberellic acid ; TSS ; sugar yield ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 22
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: This Special Issue focuses on feeding and feed technology advances and challenges in aquaculture. These are of particular interest since aquaculture and fisheries are considered crucial sources of animal protein in human diets, providing around 17% of global edible animal protein. Special attention is given to alternative sources of fish meal and how substitutions can influence the metabolism, immune response, and disease resistance of the targeted species. Moreover, the impact of plant extracts on growth performances, physiological responses, immunity, and intestinal health is addressed.
    Schlagwort(e): Pacific bluefin tuna ; squid meal ; krill meal ; heat treatment ; growth performance ; dietary protein ; glycolipid metabolism ; immune response ; Streptococcus agalactiae ; high temperature ; Macleaya cordata extract ; serum lipid ; antioxidant ability ; intestinal microbiota ; intestinal health ; Anguilla rostrata ; feed additives ; immune gene expressions ; antioxidant defensive system ; Spirulina ; digestive enzymes ; hepatic enzymes ; gene expression ; aquaculture ; cyanobacteria ; Bangladesh ; children ; dry fish ; malnutrition ; minerals ; nutrients ; protein ; vitamins ; women ; whitebait ; larval diet ; formulated feed ; PUFA ; HUFA ; herbal medicines ; growth ; striped catfish ; immunity ; largemouth bass ; pompano ; amberjack ; red drum ; algal oil ; olive flounder ; fish meal replacement ; meat meal ; regression analysis ; innate immune response ; Lamiaceae ; fish ; health ; antioxidant ; nutrition ; Litopenaeus vannamei ; Yarrowia lipolytica ; Haematococcus pluvialis ; astaxanthin ; pigmentation deposit ; antioxidation ; Ctenopharyngodon idellus ; Phragmites australis ; serum biochemistry ; immune-related factors ; immune gene ; alternative protein source ; essential amino acid ; insect meal ; protein replacement ; T. tinca ; whole-body composition ; feed ; insects ; innovation ; sustainability ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNA Agribusiness and primary industries::KNAF Fisheries and related industries
    Sprache: Englisch
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  • 23
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-30
    Beschreibung: Environmental abiotic stresses, such as extreme temperatures, drought, excess light, salinity, and nutrient deficiency, have detrimental effects on plant growth, development, and yield. Plants are equipped with various adaptation mechanisms to cope with such unfavorable conditions. Our understanding of plants’ abiotic stress responses is crucial to maintaining efficient plant productivity. This book on the responses of plants to environmental stresses is an attempt to find answers to several basic questions related to their adaptation and protective mechanisms against abiotic stresses. The following chapters of the book describe examples of plants’ protective strategies, which cover physiological, cellular, biochemical, and genomic mechanisms. This book is aimed for use by advanced students and researchers in the area of stress biology, plant molecular biology and physiology, agriculture, biochemistry, as well as environmental sciences.
    Schlagwort(e): Heterogeneous water stress ; Phyllostachys edulis ; Rhizome ; Vascular bundle ; Stress Signal ; Physiological characteristics ; isoprene ; ocimene ; heat stress ; water stress ; ramie (Boehmeria nivea (L.) Gaudich) ; transcriptome ; nitrogen deficiency ; resilience ; nitrogen-use efficiency ; eggplant ; heat shock factor ; gene family ; expression profile ; abiotic stress ; Malus. ‘Prairifire’ ; photosynthetic characteristics ; chlorophyll a fluorescence ; 2-dimensional electrophoresis ; diurnal regulation ; OsGI ; rice ; U-box E3 ligase ; barley ; ABC gene family ; gene expression ; alarm photosynthesis ; Antarctic ; oxalate oxidase ; Elymus sibiricus, seed aging ; isobaric tandem mass tag labeling ; reactive oxygen species ; parallel reaction monitoring ; Dendrobium catenatum ; superoxide dismutase (SOD) ; stresses ; antioxidative enzyme activity ; low pH ; proline ; protein ; wheat ; WRKY transcription factor ; gene structural characteristics ; regulatory mechanism ; drought ; salinity ; heat ; cold ; ultraviolet radiation ; rainfed ; irrigated ; Gossypium hirsutum ; antioxidant activity ; growth inhibition ; ion homeostasis ; salt stress ; rhizoboxes ; gaseous exchange ; sub-Saharan Africa ; root length density
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 24
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-01-08
    Beschreibung: Wine has a complex matrix with many volatile compounds present, which evolves over time. These volatile compounds are important to wine quality as they contribute to the aroma and varietal characteristics of wine. Recent development in the analysis of volatile compounds in wine has greatly improved our understanding of the complexity of wine aroma. Analytical methods used for wine aroma fingerprinting have shown potential in determining the origin and quality of wine. Thus, research on volatile compounds responsible for wine aroma and their correlation with wine provenance and wine quality have increasingly attracted great interest from researchers and winegrowers. This Special Issue presents the latest research regarding wine aroma compounds, including, but not limited to, the topics on the characterization of aroma compounds in grapes and wine, factors influencing the production of aroma compounds in wine during fermentation and maturation, and analytical methods for wine aroma analysis.
    Schlagwort(e): marselan wine ; aroma compounds ; indigenous yeast strains ; Saccharomyces ; non-Saccharomyces ; icewine ; Vidal ; yeast ; sensory analysis ; amino acid ; fruity ester ; wine aroma ; nitrogen management ; Pearson correlation analysis ; carbon metabolism ; Vitis davidii Foёx ; spend coffee grounds ; fermentation ; sensory property ; volatile profile ; yeast protein hydrolysate ; nitrogen supplementation ; volatile compounds ; wine higher alcohols ; wine esters ; monoterpenes ; triangle test ; check-all-that-apply ; correspondence analysis ; Cochran’s Q-test ; nutrients ; central composite design ; Saccharomyces cerevisiae ; wine ; strain effect ; aromas ; non-Saccharomyces yeasts ; ethanol tolerance ; ultraviolet irradiation ; diethyl sulfate mutagenesis ; vineyard mechanization ; phenolics ; sensory properties ; anthocyanins ; bentonite ; cold soaking ; colour ; pathogenesis-related proteins ; Pinot noir ; tannin ; antioxidants ; glutathione ; glutathione-enriched inactivated dry yeasts ; methoxypyrazines ; oxidation ; Sauvignon Blanc ; thiols ; aroma profile ; grape pomace ; model juice ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::T Technology, engineering, agriculture
    Sprache: Englisch
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  • 25
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.
    Schlagwort(e): QH301-705.5 ; Q1-390 ; Werner Syndrome ; n/a ; A549 cells ; epigenetic ; neurodegeneration ; Genome integrity ; adaptation ; cellular senescence ; genome instability ; Werner Syndrome Protein ; lipofuscin ; cell cycle checkpoints ; exonuclease 1 ; template-switching ; energy metabolism ; mutation frequency ; DNA replication ; fork regression ; motor neuron disease ; Microsatellites ; Alzheimer’s disease ; chromatin remodeler ; repair of DNA damage ; AP site analogue ; mutagens ; replication timing ; Thermococcus eurythermalis ; nucleolar stress ; gene expression ; mutations spectra ; origin firing ; Fanconi Anemia ; superfamily 2 ATPase ; DNA translocation ; DNA repair ; SSB signaling ; homologous recombination ; common fragile sites ; 8-chloro-adenosine ; replication ; genome stability ; mutagenicity ; fork reversal ; multiple sclerosis ; non-B DNA ; protein stability ; heterogeneity ; ubiquitin ; SenTraGorTM (GL13) ; replication restart ; EdU ; ?-arrestin ; NER ; aging ; SSB end resection ; oxidative stress ; ATR ; dormant origins ; R loops ; DNA damage response ; Difficult-to-Replicate Sequences ; DNA double-strand repair ; endonuclease IV ; ALS ; double strand break repair ; premature aging ; replication stress ; EXO1 ; POL? ; translesion synthesis ; strand displacements ; G2-arrest ; DNA replication pattern ; SSB repair ; genome integrity ; G protein-coupled receptor kinase interacting protein 2 (GIT2) ; MMR ; replicative stress ; senolytics ; spacer ; interactome ; ATR-Chk1 DDR pathway ; C9orf72 ; replication fork restart ; translesion DNA synthesis ; DNA damage ; mismatch repair ; DNA replication stress ; DNA helicase ; Polymerase kappa ; DNA fiber assay ; H1299 cells ; TLS ; APE2 ; ageing ; cell death ; chromosome ; TopBP1 ; barley ; clock proteins ; post-translational modification ; 8-oxoG ; S phase ; ataxia telangiectasia mutated (ATM) ; G protein-coupled receptor (GPCR) ; Polymerase eta ; cancer ; G protein-coupled receptor kinase (GRK) ; helicase ; genomic instability ; Parkinson’s disease ; nucleotide excision repair ; SupF ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 26
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-02-20
    Beschreibung: Metabolic syndrome is defined by a cluster of interrelated cardiovascular risk factors (hyperglycemia, hypertension, dyslipidemia, insulin resistance, and central adiposity), linked to a chronic, systemic, and low-grade inflammation, which severely increases the risk of type II diabetes and cardiovascular disease. A growing body of evidence generated in the last decades has shown that not only the energy balance but also the macro-, micro-, and non-nutrient composition of the diet may influence the onset and progression of metabolic syndrome. However, further research is required to increase our understanding about the contribution of diet to metabolic syndrome prevention.
    Schlagwort(e): animal experimentation ; diet ; nutrition ; ingredients ; lard ; fibers ; fructose ; diet coloring ; autoclaving ; irradiation ; Passiflora setacea ; bioactive compounds ; phenolic compounds ; cardiovascular diseases ; nutrigenomics ; gene expression ; immune system ; cytokines ; insulin ; HDL ; diabetes mellitus ; dietary pattern ; metabotype ; metabolic phenotype ; Mediterranean Diet Score ; Alternate Healthy Eating Index ; atherosclerosis ; plaque burden ; lycopene ; tomato ; type 2 diabetes mellitus ; cis- and trans-isomers ; nutrients ; hypertension ; blood pressure ; management ; prevention ; mitochondria ; metabolic syndrome ; mitochondrial dysfunction ; balanced diet ; lifestyle ; Mediterranean diet ; plant-based diet ; DASH diet ; low-carbohydrate diet ; high-protein diet ; low-fat diet ; omega-3 fatty acids ; metabolism ; inflammation ; atherothrombosis ; clinical trials ; legacy effect ; metabolic memory ; cardiovascular disease ; diabetes ; dyslipidaemia ; abdominal obesity ; animal protein ; protein intake ; Alpha-linolenic acid ; docosahexaenoic acid ; rumenic acid ; punicic acid ; enriched eggs ; waist circumference ; obesity ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
    Sprache: Englisch
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  • 27
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: Renal cancer is a health problem of major concern worldwide. Although tyrosine kinase inhibitors and immune check-point blockade treatments, alone or in combination, are giving promising results, failures are quite frequent due to intratumor heterogeneity and to the acquisition of drug resistance. The spectrum of renal cell carcinoma subtypes is wide. Up to 70–80% of renal tumors are clear cell renal cell carcinomas, a clinically aggressive tumor subtype linked to VHL gene inactivation. Next in frequency, the papillary renal cell carcinoma category encompasses an intricate puzzle of classic and newly described entities with poorly defined limits, some of them pending definite clarification. Likewise, the chromophobe–oncocytoma duality, the so-called hybrid tumors and oncocytic neoplasms, remain to be well profiled. Finally, a growing list of very uncommon renal tumors linked to specific molecular signatures fulfill the current portrait of renal cell neoplasia. This Special Issue of Cancers regards RCC from very different perspectives, from the intimate basic mechanisms governing this disease to the clinical practice principles of their diagnoses and treatments. The interested reader will have the opportunity to contact with some of the most recent findings and will be updated with excellent reviews.
    Schlagwort(e): QH301-705.5 ; Q1-390 ; N-glycomapping ; n/a ; SMAD proteins ; patient survival ; pro-IL-1? ; survival prediction ; inflammation markers ; tumor migration ; prognostic factors ; practical approach ; circular RNAs in a clinico-genomic predictive model ; glycomarkers ; review ; nephrectomy ; uric acid ; VEGF inhibitors ; metabolic reprogramming ; collecting duct carcinoma ; curcumin ; metabolome profiling ; identification of circular RNAs ; IL-2 ; experimental validation of circular RNA ; Raf/MEK/ERK ; HOT ; PI3K/Akt/mTOR ; pentose phosphate pathway ; kidney cancer ; LOT ; mutation ; RCC ; polybromo-1 ; pale cell ; MMP-9 ; gene expression ; recurrence free survival ; chromosomal loss ; IL-1? ; chronic kidney disease ; glutathione transferase omega 2 ; label-free ; glutathione transferase omega 1 ; emerging entity ; copy number alteration ; FOXO3 ; predictive role ; tumor slice culture ; tyrosine kinase inhibitors ; PPP ; ESC ; CDKN1A expression ; metastasis ; PD-L1 ; diagnostic and prognostic markers ; EVI1 ; copy number loss ; RNA sequencing ; NK cells ; glutathione metabolism ; clear cell renal cell carcinoma ; renal cell cancer ; proliferation ; eosinophilic variant ; Xp11 translocation renal cell carcinoma ; prognosis ; invasion ; immune infiltration ; IL4R? ; FISH ; 11) translocation renal cell carcinoma ; tumor microenvironment ; metabolome ; hyperosmolality ; toxicity ; ALK ; drug sensitivity ; t(6 ; copy number analysis ; urine ; genetic association ; polymorphism ; solute carrier proteins ; kidney ; metastatic ccRCC ; molecular genetic features ; recurrence-free survival ; chromophobe renal cell carcinoma ; unclassified renal tumor ; overall survival ; mTOR inhibitors ; mTOR ; JAK2 ; von Hippel–Lindau ; miR-155-5p ; glycoproteomics ; PBRM1 ; miR-133b ; survival ; TFE3 ; TFEB ; oncocytic renal tumor ; immune checkpoint inhibitors ; biomarker ; MMP10 ; TCGA ; ghrelin ; EMT like ; checkpoint inhibitors ; MiT family translocation renal cell carcinoma ; gene signature ; sarcomatoid ; transforming growth factor beta ; clear cell Renal Cell Carcinoma ; tumor adhesion ; renal cancer ; unclassified renal cell carcinoma ; Papillary renal cell carcinoma (pRCC) ; miR-146a-5p ; renal cell ; everolimus ; integrins ; cytoreductive nephrectomy ; immunotherapy ; predictive factors ; immunohistochemistry ; MTA2 ; IL13R?1 ; targeted therapy ; intratumour heterogeneity ; aurora A ; TCA cycle ; AMP-activated protein kinases ; cancer-specific survival ; programmed death-ligand 1 ; efficacy ; renal cell carcinoma ; anaplastic lymphoma kinase rearrangement ; TFEB-amplified renal cell carcinoma ; statins ; cancer immunotherapy ; microRNA ; new entity ; proteome profiling ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 28
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-11-17
    Beschreibung: The transition from a growth-arrested seed to a germinating seed and then to a seedling is a crucial developmental step, dramatically affecting plant growth and viability. Before plants enter the vegetative phase of their ontogenesis, massive rearrangements of signaling pathways and switching of gene expression programs are required. It results in the suppression of the genes controlling seed maturation and the activation of those involved in regulating vegetative growth. These events are governed by the hormonal balance, primarily the abscisic acid and gibberellins, although other hormones are also involved. This book compiled the review and research papers published during the 2021–2022 biennium in the "Plant Development and Morphogenesis" section. The selection of papers covers a topic related to the most recent advances in the molecular mechanisms of metabolic switches during the seed-to-seedling transition and the relationship between seed longevity and seedling viability. It can help understand the complex regulatory mechanisms underlying the seedling establishment and facilitate the breeding of plants more tolerant to abiotic stresses.
    Schlagwort(e): desiccation tolerance ; DNA methylation ; epigenetics ; germination ; histone modification ; hormonal regulation ; miRNA ; post-germination ; seeds ; acceleration ; imbibition ; biological activity ; indexes ; germination measurements ; seed physiology ; soybean ; velocity ; V. vinifera ; grape seeds ; seed germination ; seedling formation ; seed longevity ; genetics ; quantitative trait loci ; candidate genes ; genebanks ; germinative process ; seedling establishment ; molecular tools ; gene expression ; RNA-seq ; Pisum sativum L. ; transcriptome ; seed ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Sprache: Englisch
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  • 29
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-12-21
    Beschreibung: Contamination of foods and agricultural commodities by various types of toxigenic fungi is a concerning issue for human and animal health. Moulds naturally present in foods can produce mycotoxins and contaminate foodstuffs under favourable conditions of temperature, relative humidity, pH, and nutrient availability. Mycotoxins are, in general, stable molecules that are difficult to remove from foods once they have been produced. Therefore, the prevention of mycotoxin contamination is one of the main goals of the agriculture and food industries. Chemical control or decontamination techniques may be quite efficient; however, the more sustainable and restricted use of fungicides, the lack of efficiency in some foods, and the consumer demand for chemical-residue-free foods require new approaches to control this hazard. Therefore, food safety demands continued research efforts for exploring new strategies to reduce mycotoxin contamination. This Special Issue contains original contributions and reviews that advance the knowledge about the most current promising approaches to minimize mycotoxin contamination, including biological control agents, phytochemical antifungal compounds, enzyme detoxification, and the use of novel technologies.
    Schlagwort(e): R5-920 ; RA1190-1270 ; n/a ; decontamination ; superheated steam ; quercetin glycosides ; antagonism ; mode of action ; corn ; Botrytis sp. ; AITC ; binding ; degradation ; brine shrimp bioassay ; apple pomace ; nanoparticles ; enzymatic detoxification ; Bacillus ; estrogen response element ; Fusarium ; biological detoxification ; abiotic factors ; stability ; fumonisin esterase FumD ; mycotoxigenic fungi ; Aspergillus flavus ; Aflatoxin M1 ; Fusarium graminearum ; milk ; Penicillium digitatum ; biocontrol agents ; biological control ; dry-cured ham ; mycotoxin reduction ; Fusarium sp. ; enzyme kinetics ; Penicillium nordicum ; Satureja montana ; roasted coffee ; fermentation ; crisp biscuit ; detoxification ; essential oils ; gene expression ; probiotics ; zearalenone ; mycotoxins ; degradation products ; Geothrichum citri-aurantii ; garlic-derived extracts ; Zearalenone ; biodegradation ; EU limits ; storage ; Origanum virens ; aflatoxin ; fungal growth reduction ; green chemistry ; Penicillium italicum ; deoxynivalenol ; ?-Fe2O3 ; ochratoxin A (OTA) ; wheat ; cell-free extracts of Aspergillus oryzae ; photocatalysis ; wheat quality ; post-harvest phytopathogen ; cold plasma ; pinnatifidanoside D ; ochratoxin A ; oats ; cell proliferation ; estrogen receptor ; Penicillium verrucosum ; pig production performance ; phloridzin ; maize ; biotransformation ; fumonisin ; fungi ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 30
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-04-05
    Beschreibung: The prostate is the largest accessory gland of the male reproductive tract. Together with seminal vesicles and bulbourethral glands, the prostate is responsible for the production of an alkaline fluid that forms part of the seminal fluid. The prostates of men over 40 years of age are commonly affected by several pathologies, such as benign prostate hyperplasia and cancer. Prostate cancer is one of the most frequently occurring cancers among men population worldwide. According to the World Health Organization (WHO), in the year 2018, prostate cancer affected approximately 1.28 million men and was responsible for the death of 358,989 of them. Prostate cancer development is associated with several risk factors, such as older age, black ethnicity, a family history of disease, an increased body mass index and obesity. In this way, the risk of prostate cancer development may be reduced through the consumption of a healthy diet full of fruits and vegetables, practice of physical exercise and maintenance of a healthy weight.Despite several approaches being available for prostate cancer treatment, the number of prostate cancer deaths is continuously increasing, which emphasizes the need to search for new methods for precocious diagnosis and more effective treatment. Animal models, including rodents, have greatly contributed to the study of biopathology and the prevention and treatment of prostate cancer.This Special Issue presents original research works, case reports and reviews concerning the diagnosis, treatment and prognosis of prostate cancer, highlighting new advances in this field.
    Schlagwort(e): neurotoxicity ; testosterone ; androgen-deprivation therapy ; cognitive function ; sleep ; depression ; prostate cancer ; long noncoding RNA ; NEAT1 ; laser capture microdissection ; diagnostic algorithm ; prostate health index ; biopsy ; Gleason score ; magnetic resonance ; positron emission tomography ; diagnosis ; imaging ; prostate-specific membrane antigen ; radical prostatectomy ; pelvic lymph node dissection ; lymph node invasion ; preoperative nomogram ; bone metastasis ; lymph node metastasis ; liver metastasis ; gene expression ; meta-analysis ; focal adhesion ; protein filament ; androgen receptor signaling ; biomarker ; circulating tumor cells ; Wnt ; β-catenin ; Wnt5A ; breast cancer ; DKK1 ; radiomic features ; classification ; risk stratification ; computed tomography ; prostate ; cancer ; urine ; PUR ; PUR-4 ; Gleason pattern 4 ; STEAP1 ; DNA methylation ; histone deacetylation ; bioinformatics ; Circulating Tumor Cell (CTC) ; prostate cancer (PCa) ; liquid biopsy ; cancer recurrence ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Sprache: Englisch
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  • 31
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-08-12
    Beschreibung: Rabbit livestock is especially important in the Mediterranean area and in the semi-arid zones of Africa, Asia, and America, representing a valuable alternative source of good animal protein of high quality (low fat and low cholesterol). However, rabbit husbandry should adapt to be a competitive and sustainable sector. In addition, it must maintain a balance between rabbit welfare, customer demands, and breeder requirements. Then, improvement in breeding systems is needed and may involve avoiding hormones and antibiotics in rabbit management; enhancing the efficiency of reproductive procedures such as artificial insemination systems and freezing of semen and embryos; extending the productive lifespan of does; improving genetic selection systems; and adjusting nutritional systems to optimize the physiological status of animals and the immune response. This Special Issue concerns all these challenges in increasing rabbit productivity and sustainability.
    Schlagwort(e): Oryctolagus cuniculus ; SNPs ; SLAF-seq ; genome-wide association study ; growth trait ; myeloperoxidase ; lysozyme ; rabbits ; viral infection ; rabbit hemorrhagic disease ; goji berries ; rabbit ; insulin resistance ; leptin ; non-esterified fatty acids ; pregnancy ; lactation ; body condition score ; principal component analysis ; gene expression ; endometrium ; oviduct ; spermatozoa ; seminal plasma ; inflammation ; angiogenesis ; corpus luteum ; reproduction ; genomic selection ; imputation ; litter size ; genomic simulation ; artificial insemination ; antibiotics ; antibacterial activity ; semen quality ; reproductive performance ; sperm quality ; cryopreservation ; animal model ; assisted reproductive technology ; CTSS ; granulosa cells ; proliferation ; apoptosis ; hormone secretion ; body composition ; fertility ; kits born alive ; rabbit does ; feed intake ; free tri-iodothyronine ; thyroxine ; insulin ; glucose ; corticosterone ; NEFA ; fetus ; placenta ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFZ Animals & society
    Sprache: Englisch
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  • 32
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-05-06
    Beschreibung: The Identification of the Genetic Components of Autism Spectrum Disorders 2019 will serve as a resource for laboratory and clinical scientists as well as translational-based researchers, primary healthcare providers or physicians, psychologists/psychiatrists, neurologists, developmental pediatricians, clinical geneticists, and other healthcare providers, teachers, caregivers and students involved in autism spectrum disorders (ASD) with the goal to translate information directly to the clinic, education and home setting. Other professionals, students and families might find this textbook of value based on better awareness, causes and understanding of genetic components leading to autism and open avenues for treatment. Genetics play a role with up to 90% of autism, with over 800 currently recognized genes contributing to causes, clinical presentation, treatment, and counseling of family members. This textbook includes 13 chapters divided into three sections (clinical, genetics, other) written by experts in the field dedicated to research and clinical care, description, treatment and generating relevant reviews for ASD and related disorders impacting gene expression, profiling, and pathways. Identification of potential risk factors will be discussed, including obesity, microbiota, malignancy, and the immune system, as well as their direct or indirect contribution to ASD treatment and causation.
    Schlagwort(e): autism spectrum disorders (ASD) ; cancer ; overlapping genes and gene profiling ; super-pathways ; phenotypes and diseases ; molecular functions and processes ; 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome ; imprinting ; parent-of-origin effects ; phenotype-genotype correlation ; autism ; developmental delays ; motor delays ; microbiome ; gut ; ProSAP2 ; Phelan McDermid Syndrome ; gut–brain interaction ; leaky gut ; IL-6 ; SHANK ; collapsin response mediator protein 4 ; autism spectrum disorder ; neurodevelopmental disorder ; whole-exome sequencing ; animal model ; sex different phenotypes ; 15q11.2 BP1–BP2 microdeletion (Burnside–Butler syndrome) ; NIPA1 ; NIPA2 ; CYFIP1 ; TUBGCP5 genes ; Prader–Willi and Angelman syndromes ; magnesium transporters and supplementation ; potential treatment options ; intellectual disability ; AMPA receptors ; NMDA receptors ; guanine nucleotide exchange factor ; synaptic plasticity ; Autism spectrum disorder ; ASD ; Obesity ; Overweight ; Body mass index ; BMI ; autism candidate genes ; synaptotagmin-like protein 4 (SYTL4) ; transmembrane protein 187 (TMEM187) ; SYTL4-protein structure ; STRING-protein-protein interaction ; expression profile ; microRNA- interactions ; autism spectrum disorders ; biological networks ; genomics ; multi-omics ; network diffusion ; data integration ; genetics ; quantitative traits ; stratification by trait severity ; heterogeneity reduction ; case-control association analysis ; fragile X syndrome ; RNA toxicity ; DNA methylation ; mosaicism ; pediatrics ; MS-QMA ; AmplideX ; cytokine ; monocyte ; β-glucan ; T cell cytokine ; trained immunity ; maternal immune activation ; epigenetics ; mice ; postnatal VPA injection ; SAM ; gene expression ; nanostring ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Sprache: Englisch
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  • 33
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: Yeasts are truly fascinating microorganisms. Due to their diverse and dynamic activities, they have been used for the production of many interesting products, such as beer, wine, bread, biofuels, and biopharmaceuticals. Saccharomyces cerevisiae (brewers’ or bakers’ yeast) is the yeast species that is surely the most exploited by humans. Saccharomyces is a top-choice organism for industrial applications, although its use for producing beer dates back to at least the 6th millennium BC. Bakers’ yeast has been a cornerstone of modern biotechnology, enabling the development of efficient production processes. Today, diverse yeast species are explored for industrial applications. This Special Issue “Yeast Biotechnology 2.0” is a continuation of the first Special Issue, “Yeast Biotechnology” (https://www.mdpi.com/books/pdfview/book/324). It compiles the current state-of-the-art of research and technology in the area of “yeast biotechnology” and highlights prominent current research directions in the fields of yeast synthetic biology and strain engineering, new developments in efficient biomolecule production, fermented beverages (beer, wine, and honey fermentation), and yeast nanobiotechnology.]
    Schlagwort(e): QH301-705.5 ; TP248.13-248.65 ; bioethanol production ; mead ; nanobiotechnology ; fermentation-derived products ; flavor ; citric acid production ; enzyme production ; non-Saccharomyces yeasts ; fermented beverages ; bioreactors ; Saccharomyces cerevisiae ; wine ; beer ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 34
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: The purpose of this Special Issue is to provide a thorough and up-to-date presentation of research investigating the impact of coffee and/or caffeine intake on various health outcomes. Areas of interest include, but are not limited to, the following topics: Human clinical trials of coffee or caffeine use in relation to disease or intermediate phenotypes. Epidemiological studies of habitual coffee or caffeine intake in relation to human health, among the general public, as well as, among special populations (i.e., children, pregnant women, diabetics, cancer patients, hypertensives, etc.). Mechanisms of action of nutrients and other bioactive components of coffee/caffeine. Studies integrating genetic or physiological markers of coffee/caffeine intake to investigations of coffee and health.
    Schlagwort(e): QH301-705.5 ; Q1-390 ; TX341-641 ; coronary artery disease ; n/a ; lipids ; NADH dehydrogenase ; tea ; tinnitus ; safety ; transcriptomics ; ergogenic ; guidelines ; myocardial perfusion ; placebo ; Caffeine ; risk factors ; lysophosphatidylcholine ; pregnancy ; assisted reproduction techniques ; population ; adenosine ; liver fibrosis ; coffee consumption ; cognitive ; causation ; supplement ; mate ; adult ; gene expression ; wine ; lipidomics ; chocolate ; exercise ; protection ; Suicide ; dipyridamole ; regadenoson ; live birth ; hearing ; pharmacological ergogenic aid ; behavior ; cardiovascular disease ; gene-diet interaction ; whole-blood ; sex ; health ; systematic review ; causality ; genetic epidemiology ; implantation ; pharmacogenomics ; cognitions ; ergogenic aid ; time trial performance ; CYP1A2 ; aging ; phenolic ; country ; caffeine intake ; serum chloride levels ; polymorphism ; responders ; intoxication ; trial ; epidemiological methods ; bias ; adenosine receptor ; longevity ; did not respond ; energy drinks ; biomarkers ; individual responses ; Mendelian Randomization ; public policy ; anxiety ; the Norwegian Women and Cancer Cohort (NOWAC) ; ADORA2A ; clinical pregnancy ; caffeine metabolism ; caffeine intoxication ; cohort study ; mood ; mRNA ; alcohol consumption ; epidemiology ; caffeine ; expectancy ; accidental death ; European Prospective Investigation into Cancer and Nutrition ; cognition ; consumption ; HIV-HCV co-infection ; cytochrome P450 ; chlorogenic acids ; soda ; 24-h dietary recall ; coffee ; depression ; sport ; age ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-11-17
    Beschreibung: Microorganisms is pleased to publish this book, which reprints papers that appeared in a Special Issue on “Phototrophic Bacteria”, with Guest Editors Robert Blankenship and Matthew Sattley. This Special Issue included research on all types of phototrophic bacteria, including both anoxygenic and oxygenic forms. Research on these bacterial organisms has greatly advanced our understanding of the basic principles that underlie the energy storage that takes place in all types of photosynthetic organisms, including both bacterial and eukaryotic forms. Topics of interest include: microbial physiology, microbial ecology, microbial genetics, evolutionary microbiology, systems microbiology, agricultural microbiology, microbial biotechnology, and environmental microbiology, as all are related to phototrophic bacteria.
    Schlagwort(e): aerobic anoxygenic phototrophic bacteria ; chlorophototroph ; thermophile ; hot spring ; bacteriochlorophyll ; Alphaproteobacteria ; cyanophage ; Nostoc sp. ; label-free quantitative proteomics ; photosynthesis ; substance metabolism ; energy metabolism ; purple sulfur bacteria ; genomic phylogeny ; Ectothiorhodospiraceae ; Halorhodospiraceae ; new family and genus ; scytonemin ; ultraviolet radiation ; high light ; cyanobacteria ; Acaryochloris ; chlorophyll ; genomics ; far-red photosynthesis ; plasmid ; horizontal gene transfer ; Rhodocyclus ; purpureus ; tenuis ; gracilis ; HiPIP ; cobalamin ; whole genome sequencing ; taxonomy ; chlorophyll d ; Moss Beach ; photosynthetic pigments ; absorbance spectra ; genome sequence ; Photosystem II ; oxygenic photosynthesis ; photosynthetic reaction center ; cryo-electron microscopy ; cyclic electron flow ; ferredoxin-NADP reductase ; NDH-1 ; proton motive force ; thylakoid ; anoxygenic phototrophs ; heliobacteria ; bacteriochlorophyll g ; Heliophilum fasciatum ; Heliobacteria ; promoters ; reporters ; gene expression ; phototrophic bacteria ; transcriptional regulation ; gene transfer ; persulfide ; redox signaling ; cyclic GMP ; PpsR ortholog ; AerR photoreceptor ; light regulation ; photosynthesis gene regulators ; two-component system ; RegA ; aerobic ; copper ion ; disulfide bond ; DNA binding ; gene regulation ; purple phototrophic bacteria ; extremophile ; Halorhodospira halochloris ; Halorhodospira abdelmalekii ; light-harvesting 1 reaction center ; bacteriochlorophyll b ; thermal stability ; salt- and pH-dependence ; near infrared ; stromatolite ; shark bay ; reduction-oxidation ; photosystem II ; phycobilisome ; RNase ; light-harvesting ; aerobic anoxygenic phototrophs ; AAP ; Rhodobacter ; purple nonsulfur bacteria ; Yellowstone ; xanthorhodopsin ; vitamin B12 ; frameshifting ; evolution ; chelatase ; chlIDH ; cobNST ; phototrophic extracellular electron uptake ; comparative genomics ; transcriptomics ; Rhodovulum sulfidophilum ; Rhodovulum visakhapatnamense ; ancestral sequence reconstruction ; chlorophyll f ; far-red light photoacclimation ; Synechococcus sp. PCC 7335 ; Chloroflexus aurantiacus ; proteomic analysis ; respiration ; chlorosome ; alternative complex III ; phylogenomic and comparative genomic analyses ; conserved signature indels (CSIs) ; molecular signatures ; class Chlorobia and the families Chlorobiaceae and Chloroherpetonaceae ; Ignavibacteria ; uncultured species/strains related to Chlorobia/Ignavibacteria ; FNR ; NDH ; photoheterotrophic growth ; comparative genome analysis ; cyanobacterial photoreceptors ; phycobiliproteins ; chromatic acclimation ; linker proteins ; phylogenetic comparison ; halophiles ; alkaliphiles ; nitrogen fixation ; diazotroph ; Rhodovulum tesquicola ; hydrogen ; electron transport ; photosystem I ; microbial ecology of lakes ; bacterial community ; Lake Winnipeg ; food web dynamics ; picoplankton ; bacterioplankton ; carotenoid ; Synechocystis ; zeta-carotene isomerase (Z-ISO) ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSG Microbiology (non-medical)
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: This Special Issue contains 28 papers covering a wide range of topics related to plant genomics and genetics. The papers utilize a variety of genomic tools and techniques to explore topics such as identification of quantitative trait loci associated with flax seed yield and oil quality, mucilage and hull content in flax seeds, and genomic prediction for pasmo resistance in flax. Other papers focus on the identification and characterization of specific genes, such as the EXO70 gene family in wheat and related species, hydroxycinnamoyl transferase in tea plants, and the WRKY transcription factor GmWRKY12 in soybeans. Several papers examine gene expression and regulation in response to abiotic stress, such as drought and salt tolerance in moso bamboo, and the response to chilling in bell peppers. Other topics include genetic diversity analysis of crested wheatgrass, genome-wide analysis of chitin-binding protein gene family in peppers, and genome-wide bioinformatics analysis of MAPK gene family in kiwifruit. Overall, this Special Issue provides a comprehensive view of the current state of plant genomics research, showcasing the diversity of approaches and tools being used to better understand and improve crop plants.
    Schlagwort(e): Solanum lycopersicum ; UGlcAE gene family ; identification ; characterization ; plant hormones ; gene expression ; Jatropha curcas ; Dof gene family ; transcription factor ; phylogenetic analysis ; gene expression analysis ; warming ; BrHSFA2 ; BrHSP18.2s ; transcriptome ; alternative splicing ; Kenshin ; Verbena bonariensis ; drought stress ; transcriptome sequencing ; differentially expressed genes ; analysis ; non-coding RNA ; transcriptomes ; bell pepper ; chilling injury ; longan ; WRKY ; expression analysis ; flower induction ; abiotic stress ; chitin-binding protein ; chitinase ; pepper ; expression ; biotic stress ; flax ; genome-wide association study (GWAS) ; selective sweep ; genotyping by sequencing (GBS) ; bi-parental population ; single nucleotide polymorphism (SNP) ; seed yield ; plant height ; maturity ; fatty acid composition ; DNA methylation ; flower color chimera ; bisulfate sequencing ; comparative epigenomes ; transposon ; ornamental Prunus mume ; novel accessions ; PIC ; PCR ; EST-gSSRs ; genes ; genetic distance ; apple ; SAP gene family ; function analysis ; osmotic stress ; mitogen-activated protein kinase (MAPK) ; kiwifruit ; phylogenetic relationships ; biotic and abiotic stresses ; genotyping-by-sequencing ; Agropyron ; genetic diversity ; genetic structure ; SNP ; flaxseed ; Linum usitatissimum ; GWAS ; seed mucilage content ; seed hull content ; ZmWRKY106 ; drought tolerance ; thermotolerance ; maize ; Pyrus hopeiensis ; cp genome ; IR boundary ; phylogeny ; Betula halophile ; salt stress ; Cleistogenes songorica ; LEA proteins ; abiotic stresses ; flow cytometry ; genome size ; nuclear DNA content ; reference genome assembly ; standardization ; upland cotton ; TCP genes ; miR319 ; target genes ; tea ; hydroxycinnamoyl transferase ; ABA signaling ; hormone ; stress responsive mechanism ; salt tolerance ; transgenic hairy root assay ; soybean ; regulation and efficiency of translation ; genome-wide scale ; experimental approaches ; computational algorithms ; features of plant mRNAs ; EXO70 ; Haynaldia villosa ; gene family ; phylogenetic relationship ; subcellular localization ; expression profiling ; rice ; trihelix transcription factor ; stress response ; light ; genomic selection ; genomic prediction ; genotyping by sequencing ; pasmo resistance ; pasmo severity ; quantitative trait loci ; single nucleotide polymorphism ; Septoria linicola ; Phyllostachys edulis ; Dof transcription factor ; flowering time ; satellite DNA ; genome evolution ; plants ; next-generation sequencing ; high order repeats ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-24
    Beschreibung: Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body’s own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions.
    Schlagwort(e): angiogenesis ; vessel maturity ; vessel permeability ; hemorrhage ; atherosclerosis ; two-photon intravital microscopy ; transforming growth factor-β ; endoglin ; neovascularization ; tissue repair ; myocardial infarction ; hind limb ischemia ; critical limb ischemia ; arteriogenesis ; cell therapy ; secretomes ; AP-1 transcription factors ; JunB ; tip cell specification ; vascular development ; neurovascular interactions ; peripheral arterial disease ; biomarkers ; inflammation ; coagulation ; extracellular vesicles ; microRNAs ; machine learning ; gene therapy ; stem cells ; clinical trials ; bioengineering ; gene expression ; non-viral vectors ; 2A-peptides ; growth factors ; tube formation ; VEGF ; FGF2 ; cytokines ; animal model ; Matrigel plug assay ; cold-inducible RNA-binding protein ; extracellular cold-inducible RNA-binding protein ; CIRP ; eCIRP ; neutrophil extracellular traps ; NETs ; macrophage polarization ; apoptosis ; ischemia ; vascular smooth muscle cell ; phenotypic switch ; collateral arteries ; C57BL/6J mice ; SV-129 mice ; leukocytes ; macrophages ; neutrophils ; C57BL6 ; 129S1/Sv ; CIRBP ; 14q32 microRNAs ; HUVECs ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: Viruses of the Parvoviridae family constitute a most diverse and intriguing field of research. Parvoviruses can differ widely in their structure, genome organization and expression, virus–cell interactions, and impact on hosts. The translational implication of research on parvoviruses is relevant, since many viruses are important human and veterinary pathogens, while other viruses can be engineered as tools for oncolytic therapy or as sophisticated gene delivery vectors. Exploring the diversity and inherent complexity in the biology of these apparently simple viruses is a still challenging topic for the scientific community. The Special Issue of Viruses is a collection of recent contributions in the field of parvovirus research, encompassing many aspects of basic and translational research on viruses of the family Parvoviridae, including on their structure, replication, and gene expression in addition to virus–host interactions and the development of vaccines and viral vectors.
    Schlagwort(e): feline parvovirus ; virus-like particles ; VP2 protein ; antibodies ; AAV ; neuro-degenerative disease ; gene therapy ; antigenicity ; sequencing ; virus ; canine parvovirus ; peri-urban ; wild dogs ; disease transmission ; Australia ; parvovirus B19 ; G-quadruplex ; bioinformatics ; antivirals ; BRACO-19 ; pyridostatin ; oncolytic viruses ; rodent protoparvovirus H-1PV ; virus entry ; clathrin-mediated endocytosis ; parvovirus ; minute virus of mice ; RNA processing ; gene expression ; canine ; COVID-19 ; veterinary epidemiology ; B19V ; VP1u ; receptor ; PLA2 ; erythroid cells ; biomarker ; drug delivery ; nanocarrier ; B19 parvovirus ; detection ; cell cycle ; permissivity ; serotype ; capsid ; cryo-EM ; genome packaging ; gene delivery ; bocavirus ; Caribbean region ; new CPV-2a ; outbreak ; endemic ; nearly complete genomes ; virus evolution ; parvoviruses ; nucleus ; imaging of viral interactions and dynamics ; analysis of protein–protein interactions ; analysis of virus–chromatin interactions ; AMDV ; Aleutian disease ; mink parvovirus ; Aleutian mink disease virus ; vaccine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine
    Sprache: Englisch
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  • 39
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-11
    Beschreibung: Ornamental crops account for more than US $42 billion globally. With the exception of few floral species, limited genetic, genomic, and breeding information is publicly available, owing to the fact that the majority of breeding work is performed by the private sector. Public research programs are increasingly participating in ornamental cultivar development and genetic studies. With lower sequencing costs, genomic information of non-model species including ornamental crops is continuously becoming available. Ornamental breeding utilizes a wide array of breeding strategies ranging from traditional crossing and selection methods to the use of next-generation sequencing in genomics and transcriptomics for gene identification and trait development. A continuing search of new species for the ornamentals industry has resulted in the utilization of tools that increase diversity and in the development of alternative methods for obtaining new crops by achieving interspecific and intergeneric crosses. This Special Issue aimed to present papers on new breeding methods, novel cultivars and species entering the ornamental industry, the identification of genes conferring novel traits, technological developments in ornamentals research, and the use of next-generation sequencing to improve ornamental plants.
    Schlagwort(e): Acer buergerianum ; Acer ginnala ; Acer platanoides ; Acer tataricum ssp. ginnala ; ploidy manipulation ; sterility ; Hydrangea macrophylla ; SSR ; SNP ; linkage map ; flower senescence ; nuclease ; nutrient deficiency ; petals ; programmed cell death ; virus induced gene silencing ; bolting ; cut flower ; germinal pore ; ornamental plant ; polyploidy periclinal chimera ; Plumbaginaceae ; polyploidy breeding ; cold hardiness ; LT50 ; sucrose ; oligosaccharides ; soluble sugar metabolism ; gene expression ; breeding ; geophytes ; interspecific cross ; plant hormone treatment ; pollen-pistil interaction ; pre-zygotic barrier ; Ranunculaceae ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: Fermented foods are consumed all over the world and their consumption shows an increasing trend. They play many roles, from preservation to food security, improved nutrition and social well-being. Different microorganisms are involved in the fermentation process and the diversity of the microbiome is high.Fermented foods are food substrates that are invaded or overgrown by edible microorganisms whose enzymes hydrolyze polysaccharides, proteins and lipids to nontoxic products with flavors, aromas, and textures that are pleasant and attractive to the human consumer. Fermentation plays different roles in food processing, including the development of a wide diversity of flavors, aromas, and textures in food, lactic acid, alcoholic, acetic acid, alkaline and high salt fermentations for food preservation purposes, biological enrichment of food substrates with vitamins, protein, essential amino acids, and essential fatty acids and detoxification during food fermentation processing.
    Schlagwort(e): fermented foods ; nutritional guidelines ; legislation ; national food guides ; Saccharomyces cerevisiae ; biomass ; date extract ; optimization ; response surface methodology ; kinetic models ; antifungal ; bioprotection ; bread ; Lactobacillus plantarum ; phenyllactic acid ; Aspergillus ; Penicillium ; Fusarium ; sauerkraut ; microbiome ; fermentation ; probiotics ; high-throughput sequencing ; nutrition ; health benefits ; microbiology ; health ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-07-06
    Beschreibung: Galectins are a family of soluble beta-galactoside-binding proteins with diverse glycan-dependent and glycan-independent functions outside and inside the cell. There are sixteen recognized mammalian galectin genes, and their expression profiles are very different between cell types, tissues, and species. This Special Issue covers recent progress in the field of the cell biology of galectins, relevant concepts of galectin regulatory mechanisms, and biomedical aspects of these unique multifunctional proteins.
    Schlagwort(e): galectin-7 ; p53 ; MMP-9 ; cancer ; gain-of-function ; vasculature ; gene expression ; tube formation ; sprouting ; VEGF ; integrins ; galectin ; extracellular matrix ; microenvironment ; Yersinia enterocolitica ; YopP ; Galectin-1 ; nitric oxide ; macrophages ; epithelial tissues ; apoptosis ; targeting ; inhibitors ; β-hairpin ; β-sandwich ; blood group B ; lectin ; sugar code ; LGALS16 ; placenta ; brain tissues ; cell differentiation ; transcription factor ; miRNA ; galectin-3 ; cardiac fibrosis ; heart failure ; atrial fibrillation ; chronic inflammation ; MMPs ; microRNAs ; lncRNAs ; pectin ; structure and function ; bioactive polysaccharides ; galectin-3 inhibition ; galacto-oligosaccharides ; galectins ; intestinal epithelial cells ; β-3′galactosyllactose ; immunomodulation ; mucosal immunity ; O-GlcNAc ; unconventional secretion ; extraembryonic endoderm ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Sprache: Englisch
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  • 42
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-12-06
    Beschreibung: Aquaculture is an important economic activity for food production all around the world that has experienced an exponential growth during the last few decades. However, several weaknesses and bottlenecks still need to be addressed in order to improve the aquaculture productive system. The recent fast development of the omics technologies has provided scientists with meaningful tools to elucidate the molecular basis of their research interests. This reprint compiles different works about the use of transcriptomics and genomics technologies in different aspects of the aquaculture research, such as immunity, stress response, development, sexual dimorphism, among others, in a variety of fish and shellfish, and even in turtles. Different transcriptome (mRNAs and non-coding RNAs (ncRNAs)), genome (Single Nucleotide Polymorphisms (SNPs)), and metatranscriptome analyses were conducted to unravel those different aspects of interest.
    Schlagwort(e): RNA-Seq ; lncRNAs ; Dicentrarchus labrax ; viral infection ; nodavirus ; immune response ; fish ; T lymphocytes ; infection ; malnutrition ; inflammation ; aquaculture ; histopathology ; immunohistochemistry ; enteromyxosis ; Philasterides dicentrarchi ; turbot ; transcriptomics ; Chinese mitten crab ; Eriocheir sinensis ; transportome ; transporters ; salinity ; osmoregulation ; transcriptome ; meta-analysis ; gills ; short pentraxins ; c-reactive protein ; zebrafish ; transcript expression ; antiviral ; SVCV ; rag1 mutants ; skin ; mucosal immunity ; hypoxia ; hypo-metabolic state ; growth ; swimming performance ; metabolic landmarks ; muscle transcriptome ; glycolysis ; lipid metabolism ; protein turnover ; gilthead sea bream ; hepatopancreas necrosis disease ; metatranscriptomics sequencing ; hepatopancreatic flora ; teleost ; B cells ; single cell transcriptomics ; immunoglobulins ; immune markers ; transcription factors ; long non-coding RNAs ; hepatic transcript expression ; salmon ; microarray ; omega-6/omega-3 ratio ; nutrigenomics ; fatty acids ; liver ; muscle ; Misgurnus anguillicaudatus ; sexual size dimorphism ; polyploid size dimorphism ; comparative transcriptome ; gene expression ; edible red sea urchin ; Loxechinus albus ; RNA-seq ; reference transcriptome ; Chinese soft-shelled turtle ; Aeromonas hydrophila ; hemorrhagic sepsis ; molecular immunopathogenesis ; tripartite motif proteins ; B30.2 domain ; antiviral immunity ; Ctenopharyngodon idella ; grass carp reovirus ; metamorphosis ; brain ; RNA ; sequencing ; intermuscular bone ; development ; Megalobrama amblycephala ; Oreochromis niloticus ; histological structure ; Atlantic salmon ; smoltification ; genome ; mRNAs ; miRNAs ; sox family genes ; Pelodiscus sinensis ; estradiol ; pseudo-female ; sex-related ; heterosis ; heterobeltiosis ; environment ; transgressive genes ; conserved miRNA ; high-throughput sequencing ; lumpfish ; novel miRNA ; RT-qPCR ; heat shock protein ; co-chaperon network ; salinity-alkalinity adaptation ; molecular evolution ; Lateolabrax maculatus ; genomics ; stress response ; HPI-axis ; neuroendocrine-immune interaction ; common carp ; poly-unsaturated fatty acid ; fatty acid elongase ; association study ; genomic selection ; bulked segregant analysis ; SNP ; association analysis ; joint effect ; seawater adaptation ; microRNAs ; small-RNA sequencing ; microarray transcriptome ; European seabass ; chronic inflammation ; opioid receptors ; immune status ; whole-transcriptome sequencing ; sex differentiation ; non-coding RNAs ; ceRNA ; red cusk-eel ; thermal stress ; liver transcriptome ; oxidative damage ; protein folding ; hepatic enzymes ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KNA Primary industries::KNAF Fisheries & related industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-11-30
    Beschreibung: Polyphenols are natural phytochemicals recognized as one of the largest and most widespread classes of plant constituents occurring throughout the plant kingdom. Over the years, polyphenols have attracted the attention of the scientific community due to their potential health-promoting effects. Owing to their several interesting properties, polyphenols have aroused considerable interest, shedding light on their chemistry, reactivity, biological properties and their beneficial effects on both plants and humans. As a result of these investigations, a huge number of research works have been reported on polyphenols. However, despite the voluminous literature studying polyphenols and their impact on human health, there are still many issues waiting to be explored in order to explain and elucidate the positive effects of polyphenols on human health. This Special Issue was intended to gather up-to-date knowledge related to the cutting-edge research in the broad scientific area of polyphenols, providing an opportunity to show the latest advances in the exploration of polyphenols and their health beneficial effects. The special issue was a great success with more than 50 published manuscripts covering various aspects related to polyphenols and their role in human health. We are confident that this Special Issue will be of great interest to the scientific community, and will contribute to the improvement of knowledge regarding the area of polyphenols, leading to a better understanding of their role in human health.
    Schlagwort(e): polyphenolic curcumin ; cisplatin ; combination therapy ; breast cancer ; apoptosis ; gemini surfactant nanoparticles ; Mucuna pruriens seed ; neuroprotective activity ; Parkinson’s disease ; anti-acetylcholinesterase activity ; L-dopa ; Mitrephora sirikitiae ; anti-inflammation ; lignans ; polyphenols ; mRNA expression ; cytokines ; gemini curcumin ; colorectal cancer ; RNA sequencing ; PPI network ; differentially expressed genes ; Ericaceae ; LC–DAD/ESI–MS ; phenolic compounds ; flavonoids ; antioxidant activity ; Artemia salina Leach ; resveratrol ; hexavalent chromium ; 8-hydroxydeoxyguanosine adduct repair ; endogenous antioxidant system ; antigenotoxic ; Opuntia sp. ; prickly pear ; inflammation ; ginseng leaf ; far-infrared irradiation ; ginsenosides ; antioxidants ; health benefits ; polysaccharides ; freeze-drying ; spray-drying ; antidiabetic ; Averrhoa carambola L. ; dihydrochalcone ; flavone glycosides ; obesity ; Oxalidaceae ; type 2 diabetes ; Alchemilla viridiflora Rothm. ; SARS-CoV-2 ; COVID-19 ; spike glycoprotein ; neuropilin-1 ; in vitro ; in silico ; Origanum compactum ; HPLC-PDA-ESI/MS ; antibacterial activity ; bioactive compounds ; nutraceuticals ; phenols ; pomegranate peels ; phytochemical ; wistin ; NADES ; total polyphenolic content ; enzyme inhibition ; functional food ; natural medicine ; Alzheimer cholinesterase inhibitors ; Maqui ; platelets ; phenolic compounds and cardiovascular ; phenolic acids ; sinapic acid ; ACE inhibition ; hypertension ; endothelial dysfunction ; Graminex pollen ; hydroalcoholic extract ; oxidative stress ; gene expression ; TRPV1 ; pterostilbene ; antioxidant ; bioavailability ; cancer ; diabetes ; Nrf2 ; Rosmarinus officinalis ; chemical analysis ; glioblastoma ; rhabdomyosarcoma ; red onion ; phytochemicals ; H9c2 rat cardiomyoblast ; primary human fibroblasts ; blood disorder ; haemoglobin ; natural product ; nutraceutical ; nutritional disease ; lichens ; neuroprotection ; cetrarioid clade ; grape polyphenols ; sarcopenia ; skeletal muscle ; clinical trial ; R. conduplicans ; lichen ; secondary metabolites ; DNA damage ; α-glucosidase inhibition ; adlay ; adlay testa ; antiglycation ; phenolic acid ; grape pomace ; anti-inflammatory ; curcumin ; poly(glycerol sebacate) ; nanoparticles ; drug delivery system ; human cervical cancer ; baicalein ; mangiferin ; quercetin ; diabetes mellitus ; peripheral artery disease ; cardiovascular diseases ; Cyperus esculentus ; tiger nut ; metabolomics ; UHPLC-ESI-QTOF-MS/MS ; foodomics ; scopolamine ; memory impairments ; phenol compounds ; polydatin ; 3-O-β-d-resveratrol-glucopyranoside ; cervical cancer ; lung cancer ; ovarian cancer ; nanosuspension ; antioxidant properties ; LPS-induced inflammation ; NO-scavenging activity ; mountain tea ; Lamiaceae ; iridoids ; phenylethanoids ; ultrasound-assisted extraction ; melittoside ; ajugoside ; verbascoside ; ferulic acid ; apoptosis and cell cycle arrest ; anti-angiogenesis ; anti-metastasis ; synergism ; Cymbopogon schoenanthus ; hyaluronidase ; acetylcholinesterase ; neurodegeneration ; skin ; hair ; human health ; immobilized PTP1B ; drug screening ; cell surface display ; salvianolic acid B ; traditional Chinese medicine ; Salicornia ; extraction technologies ; agro-industrial by-products ; biological activity ; circular economy ; health effects ; re-integration ; waste management ; blood orange peels ; infrared-assisted extraction ; optimization ; Aflatoxin B1 ; Achillea millefolium ; bioaccessibility ; Caco-2 absorption ; in vitro digestion ; sterol regulatory element-binding protein 1 ; human oral squamous cell carcinoma ; autophagy ; epidermal fatty acid-binding protein ; lentil hull ; enzymatic hydrolysis ; microwave-assisted extraction ; oligosaccharides ; Alocasia gigantea ; hepatocellular carcinoma ; histopathology ; UHPLC–DAD–ESI–MS/MS ; Salvianolic acid B ; matrix metalloproteinase 9 ; gelatinase B ; MDA-MB-231 human breast cancer cells ; TIMP-1 ; agri-food wastes ; sustainability ; polyphenols bioavailability ; polyphenols activity ; cosmeceuticals ; nano-delivery ; health ; Lithocarpus litseifolius ; trilobatin ; phloridzin ; phloretin ; metabolic pathway ; bioactivity ; honey ; functional beverage ; characterization ; alcoholic beverage ; fermented beverage ; functional foods ; beneficial effects ; biological treatment ; bioreactors ; water ; aerobic granular sludge ; conventional active ted sludge ; biofilter ; photobioreactor ; membrane bioreactor ; bio-electrochemical systems ; chitosan ; Indian borage ; biotic elicitor ; insect-based foods ; Folin–Ciocalteu method ; phenols and flavonoids ; polyphenols bioactivity ; cereal ; pre-harvest sprouting ; antiradical capacity ; antitumor activity ; bee products ; phenylamides ; multivariate statistical analysis ; Juniperus sabina ; cupressuflavone ; intranasal ; pharmacokinetic ; motor coordination ; oregano ; box–behnken ; phenolics ; HPLC-PDA analysis ; UPLC-Q-TOF MS ; olive pomace ; PBMC ; immune gene expression ; HPLC-DAD ; metabolome ; phenolic bioaccessibility ; propolis ; total phenolic compounds ; antioxidant capacity ; UHPLC-DAD-ESI-MS ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Sprache: Englisch
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  • 44
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: Nowadays, assisted reproductive technologies (ARTs) have a pivotal role not only in achieving fertilization in subfertile animals, but they are also involved in the management of the herd, decreasing disease spread and even allowing offspring sex selection. Nonetheless, there are differences between species or even within species that have led researchers worldwide to focus on those differences in order to bypass these specific difficulties. This Special Issue, titled “The Era of Assisted Reproductive Technologies Tailored to the Specific Necessities of Species, Industry and Case Reports” and published in Animals, is composed of 12 original manuscripts and three reviews that offer an overview of current and future ARTs used to improve reproductive outcomes, mainly focused on farm animals, such as horse, pig, bovine, rabbit and ovine species. Thus, the Special Issue covers information from the classical point of view, including comparative studies of different semen extenders, to the most advanced technologies of sperm selection by thermotaxis or chemoattractants, as well as the improvement of sperm features by red light irradiation. The female and embryo contributions to ART outcomes are also covered, for instance, with a study that improves our knowledge by the metabolomic description of follicular fluid composition or the description of better culture conditions of oocytes. In brief, this Special Issue provides a balanced overview of emerging techniques and technologies used to preserve, improve, rescue or even create fertility for domestic farm animals with high economic impact.
    Schlagwort(e): IVM ; oocytes ; equine ; metabolomic ; embryo transfer ; reproductive fluids ; pregnancy ; vitrification ; calving ; selection programme ; embryo vitrification ; Gompertz growth curve ; biobanking ; reproductive performance ; stallion sperm ; capacitation ; penicillamine ; thermotaxis ; selection ; BMP15 ; ram ; semen ; semen freezing ; semen extender ; stallions ; semen quality ; fertilizing ability ; Tris ; boar spermatozoa ; perfluorinated compounds ; PFHxS ; PFOS ; spermatozoa toxicology ; glucocorticoid receptor ; gene expression ; RT-qPCR ; seminal plasma ; female genital tract ; rabbit ; spermatozoa ; oocyte ; in vitro fertilization ; extracellular vesicles ; assisted reproductive technologies ; embryo ; oocyte competence ; livestock production ; assisted reproductive technology ; embryo development ; micromanipulation ; in vitro production ; nanoparticles ; liposomes ; exosomes ; cryopreservation ; sheep ; ovary storage ; transport ; in vitro embryo production ; sperm selection ; chemotaxis ; IVF ; IVC ; porcine ; cryopreserved sperm ; sperm–oviduct interaction ; ARTs ; equines ; horse ; sperm ; red light irradiation ; extender ; straw ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-09
    Beschreibung: The purpose of this book was not to provide a comprehensive overview of the vast arena of how fungi and fungal metabolites are able to improve human and animal nutrition and health; rather, we, as Guest Editors, wished to encourage authors working in this field to publish their most recent work in this rapidly growing journal in order for the large readership to appreciate the full potential of wonderful and beneficial fungi. Thus, this Special Issue welcomed scientific contributions on applications of fungi and fungal metabolites, such as bioactive fatty acids, pigments, polysaccharides, alkaloids, terpenoids, etc., with great potential in human and animal nutrition and health.
    Schlagwort(e): fungal pigment ; natural dye ; spalting ; Scytalidium cuboideum ; dramada ; sustainable clothing ; selenium ; biofortification ; transporters ; mycorrhizal fungi ; plant growth-promoting rhizobacteria (PGPRs) ; fungal pigments ; textile dyeing ; toxicity testing ; biotechnological approaches ; challenges ; limits ; Saccharomyces boulardii ; Saccharomyces cerevisiae ; probiotics ; gastrointestinal tract ; Alginate ; β-glucan ; oligosaccharides ; elicitation ; Sargassum species ; Sparassis latifolia ; polyphenol ; antioxidant ; agave mezcalero bagasse ; apple bagasse ; solid-state fermentation ; secondary metabolites ; Pleurotus ostreatus ; Endophytic fungi ; Hyptis dilatata ; Pestalotiopsis mangiferae ; Pestalotiopsis microspora ; chemical elicitors ; antibacterial activity ; LC–ESI–Q–TOF–MS ; yeast ; biological control ; postharvest decay ; fruit ; mycorrhizae ; elevated CO2 ; Thymus vulgare ; growth ; photosynthesis ; metabolites ; biological activity ; Candida albicans ; non-albicans Candida species ; Candida auris ; aromatic alcohols ; fungi ; metabolomics ; NTCD ; additives ; functional foods ; nutraceuticals ; sustainability ; healthy aging ; Mortierella alpina ; animal fat by-product ; arachidonic acid ; ATR-FTIR spectroscopy ; Mucor circinelloides ; high-throughput screening ; metal ions ; phosphorus ; lipids ; biofuel ; FTIR spectroscopy ; bioremediation ; co-production ; natural colorants ; filamentous fungi ; stirred-tank bioreactor ; biodegradable films ; food package ; bioactive compounds ; FIP ; human health ; immunomodulation ; induced apoptosis ; lectin ; medicinal mushrooms ; polysaccharide ; terpenes and terpenoids ; melanin ; carotenoids ; polyketides ; azaphilones ; antitumor ; medical roles ; sphinganine-analog mycotoxins ; fumonisins ; AAL-toxin ; chemical structure ; toxicity ; genetics and evolution ; biosynthesis ; livestock ; ewes ; energy ; cytokines ; yeasts ; liquid swine diets ; MALDI-TOF ; biochemical identification ; growth temperature Ancom Gas Production System ; Candida krusei ; Candida lambica ; M. purpureus ; red yeast rice ; cholesterol reduction ; probiotic potential ; natural colorant ; extraction ability ; marine fungi ; Talaromyces albobiverticillius ; aqueous two-phases system extraction ; ionic liquids ; feed additive ; probiotic ; Sporidiobolus ruineniae ; tannase ; micro-fungi ; macro-fungi ; Ganoderma ; kombucha ; anticancer ; carotenoid ; medicinal mushroom ; mycobiome ; antimicrobial ; antifungal ; bioconversion ; cheese ; dairy ; Sclerotinia ; secondary metabolite ; endophytic fungi ; uncommon secondary metabolites ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 46
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-30
    Beschreibung: Malignant mesothelioma (MM) is a rare and aggressive cancer, related to chronic inflammation and oxidative stress caused mainly by exposure to asbestos. Although this mineral has been banned for decades in many countries, epidemiologists predict the MM epidemic will last past 2040, raising many concerns in public health given its late diagnosis, dismal prognosis, and lack of current efficient therapies.To deal with this situation, important breakthroughs have recently been made in the understanding of MM’s complex biology and the carcinogenic process of the different patterns of the disease. Examples of these include the development of new biomarkers and the deciphering of gene–environment interactions, molecular mechanisms of invasiveness, deregulated pathways, altered expression of miRNAs, DNA damage repair, or metabolic profile. From now on, MM’s aggressive and chemoresistant character appears linked to a polyclonal malignancy, and heterogeneity in molecular alterations.Given these improvements, new therapeutic targets are being explored to solve the double challenge faced by clinicians. The first is to reduce tumor development and its wasting consequences as soon as possible, without resistance and with limited toxicity. The second is to stimulate the recognition of tumor cells by the induction of a specific immune response. This Special Issue will highlight all these aspects.
    Schlagwort(e): well-differentiated papillary mesothelioma ; WDPM ; malignant mesothelioma ; DNA sequencing ; mutation ; mesothelioma ; tumor suppressor ; targeted therapy ; immunotherapy ; biomarkers ; proteomics ; macrophage-capping protein ; fatty acid-binding protein ; laminin subunit beta-2 ; selenium-binding protein 1 ; carcinogenesis ; malignant pleural mesothelioma ; asbestos exposure ; DNA methylation ; lymphocyte-to-monocyte ratio ; epigenome-wide analysis ; survival analysis ; metabolomics ; radiotherapy ; cancers ; inflammation ; infiltrating immune cells ; prognostic biomarker ; predictive biomarker ; immune therapy ; VATS ; extrapleural pneumonectomy ; pleurectomy decortication ; therapy response ; survival ; FDG ; PET-CT ; mesothelium ; oxidative stress ; redox-sensitive factors ; asbestos ; carbon nanotubes ; protein-protein interactions ; systems biology ; network analysis ; drug repurposing ; pleural mesothelioma ; gene expression ; immunogenicity ; sarcomatoid ; epithelioid ; first line ; meta-analysis ; systematic review ; MPM ; lurbinectedin ; DNA damage response ; histotype ; Hippo pathway ; NF2 ; BAP1 ; CDKN2A ; PTCH1 ; SETD2 ; MTAP ; liquid biopsies ; circulating tumor DNA ; plasma ; cancer-specific mutations ; genomics ; cancer biomarkers ; tumor microenvironment ; tumor-associated macrophages ; dendritic cells ; immunohistochemistry ; interaction analysis ; pleural effusion ; n/a
    Sprache: Englisch
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  • 47
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-12-21
    Beschreibung: Natural products and the preparations based on them play a stable and ever-increasing role in human and veterinary medicine, agriculture, in food and the cosmetic industry, and in an increasing number of other fields. Their importance is based on the fact that they are mostly bound to renewable sources, which in fact makes them valuable within a circular economy, inter alia. At the same time, natural products provide the origin of stereochemistry, optical activity, regioselectivity, chirality, and many other concepts and directions within science, development, and industry in a scope, which is indispensable. They serve as a constant powerful stimulus and model that inspires researchers to create new effective tools, similar to natural ones, for controlling bioregulation mechanisms and solving practical problems. This was the reason for organizing this Special Issue aimed at underlining the current developments in all the fields connected to natural products.
    Schlagwort(e): T1-995 ; TP155-156 ; varioxiranol A ; natural enantiomer ; n/a ; ribosomally synthesized ; triterpenoids ; apo-CpcB ; water resistance ; radical scavenger ; bardoxolone methyl ; antioxidant activity ; octadecanoid ; derivatives ; inhibitor ; chlorogenic acid ; biosynthesis ; microbial biosynthesis ; flow cytometry ; adhesive ; phycocyanin ; antioxidant ; anticancer drug ; resource chemistry ; ginkgolide ; anti-inflammation ; salt stress ; polyphenol ; synthesis of natural products ; rheumatoid arthritis ; PEGylated purpurin 18 ; photosensitizer ; RiPP ; isosorbide ; bioactivity ; cell opening ; stilbene ; tea tussock moth ; flavonoids ; flexible polyurethane foam ; gene expression ; genetical transformation ; research progress ; oleic acid-elicited ; pharmacokinetic features ; phenolic acid ; Plantago depressa ; platelet-activating factor receptor ; photodynamic therapy ; fatty acid ; soy protein isolate ; apoptosis ; HepG2 cells ; cancer cells ; live-cell fluorescence microscopy ; tomato ; caffeoylquinic acids ; pinocembrin ; insect sex pheromone ; 4-epi-varioxiranol A ; natural products ; singlet oxygen ; total synthesis ; lipid-lowering effects ; reversible urethane linkages ; cytotoxicity ; bromelain ; Ramulus mori ; polysaccharides ; SlCOMT1 ; pharmacological activities ; absolute structure ; natural product ; mitochondria ; Emericella variecolor ; triglycidylamine ; Spirulina ; viscosity ; post-translationally modified peptides ; phototoxicity ; melatonin ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
    Format: application/octet-stream
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  • 48
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-11-17
    Beschreibung: Fungal infections are an important and increasing global threat, carrying not only high morbidity and mortality rates, but also high healthcare costs. Without an effective response, it is predicted that 10 million people will die per year as a result of multi-drug-resistant pathogens. A high percentage of the mortalities caused by fungi are known to be biofilm-related.This Special Issue, “Fungal Biofilms 2020”, is intended to cover the state of fungal biofilm research, from virulence and pathogenicity, to new compounds with antibiofilm and antifungal activity. We welcome reviews and original research articles covering the development/evaluation/validation of recent studies, especially those regarding multidrug resistance.
    Schlagwort(e): biofilms ; Candida albicans ; sexual biofilms ; pheromone-induced biofilms ; mating type-like (MTL) locus ; white cell ; opaque cell ; phenotypic states ; pheromone signaling ; biofilm formation ; biofilm development ; Candida haemulonii complex ; biofilm ; extracellular matrix ; catheter ; polystyrene ; virulence ; Candida ; farnesol ; tyrosol ; therapy ; combination ; planktonic growth ; echinocandins ; caspofungin ; micafungin ; Aspergillus fumigatus ; gene expression ; high-throughput screens ; biofilm inhibition ; biofilm disruption ; antimicrobial resistance ; therapeutics ; Chembridge Small Molecule Diversity library ; Galleria mellonella ; polymicrobial biofilm ; experimental method in vivo ; Candida parapsilosis ; colony morphology ; drug susceptibility ; Streptococcus mutans ; antimicrobial agents ; antibiofilm agents ; treatment ; antifungals ; natural compounds ; essential oil ; extract ; minimal inhibitory concentration (MIC) ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Sprache: Englisch
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  • 49
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: Vols 1 and 2 contain 57 papers in the Special Issue of ‘Plant Genomics 2009’ and cover a wide range of topics, highlighting the significant progress that has been made in recent years in our understanding of the genetics and genomics of plants’ growth, development, and stress responses. These studies provide valuable insights into the potential applications of genomic tools and technologies for crop improvement and sustainable agriculture, as well as fundamental questions about the evolution and function of plant genes and genomes.
    Schlagwort(e): Aristolochia ; chloroplast genome ; molecular evolution ; compare analysis ; phylogeny ; brassinosteroid-signaling kinase ; gene family ; expression profile ; alternative splicing ; intron retention ; genome-wide analysis ; drought tolerance ; foxtail millet ; LIM genes ; transgenic rice ; protein phosphatase (PP2C) ; cotton ; syntenic relationships ; expression patterns ; evolutionary analysis ; Populus trichocarpa ; multiple organellar RNA editing factor ; drought stress ; RNA editing ; genome ; β-glucosidase ; Brassica rapa ; BrBGLU10 ; pollen development ; co-expression analysis ; VQ genes family ; Eucalyptus grandis ; expression pattern ; plant hormones ; abiotic stress ; calcium-dependent protein kinases ; CDPK-related kinases ; cucurbitaceae ; hst1 ; Na+ accumulation ; SNP ; rapid generation advance ; salt tolerant ; variant annotation ; whole-genome sequencing ; expression ; genome-wide ; identification of peroxidase genes ; duplication pattern ; stress ; cassava ; ABCDE model ; cereals ; evolutionary relationships ; flower organ identity ; floral speciation ; MADS-box genes ; maize ; ZmTCP ; natural variation ; subgroup IId ; CsWRKY7 ; flowering ; Arabidopsis ; Camellia sinensis ; pomegranate ; sequence diversity ; site-specific selection ; tomato ; MADS-box ; floral organ ; fruit development ; polygalacturonase (PGs), pectin methylesterase (PMEs), collinearity analysis ; gene duplications ; expression profiling ; grapevine ; Rehmannia glutinosa L. ; replant disease ; rhizosphere microbes ; NB-LRR ; plant hormone ; apple ; aquaporin ; functional analysis ; stress tolerance ; Salicaceae ; phylogenetic relationship ; plastid genome ; comparative genomics ; repeat sequences ; stress marker genes ; sesame ; gene co-expression ; abiotic stress tolerance ; hub genes ; meta-analysis ; agrobacterium ; transient expression ; virus-induced gene silencing (VIGS) ; tobacco rattle virus (TRV) ; cassava (Manihot esculenta) ; chalcone synthase ; chromatin accessibility ; epigenetic inheritance ; genetic engineering ; methylation ; ODNs ; CRISPR/Cas9 ; genome editing ; plant breeding ; multiplex genome editing ; crop improvement ; TALEN ; ZFN ; biotic stress ; avocado ; carotenoid biosynthesis ; mesocarp ; seed ; de novo assembly from short read sequencing ; full-length transcript sequencing ; differentially expressed genes ; gene dosage ; pigment ; turnip ; gene expression ; antioxidant ; nutritional quality ; B3 superfamily ; transcription factor ; ovule abortion ; Vitis vinifera ; expression analysis ; cold response ; Pittosporum tobira ; leaf variegation ; linoleic acid ; ROS scavenging enzyme ; heat shock protein ; invasive weed ; Rhizoctonia solani ; phytohormone signaling ; systemic signal ; plant defense ; calcium signaling ; ABA ; drought ; salinity ; citrulline ; genome-wide association study ; haplotype ; watermelon ; acetolactate synthase ; ferrochelatase ; rice ; large grain gene ; large grain-isogenic Koshihikari ; fine mapping ; NGS ; GW2 ; co-integration ; gene recombination ; semidwarf gene ; d60 ; linkage ; chromosome 2 ; Brachypodium ; comparative chromosome barcoding ; dysploidy ; karyotype structure and evolution ; model grass genus ; molecular cytogenetics ; polyploidy ; plant genome ; artificial microRNA ; gene silencing ; Lagerstroemia indica ; ornamental value ; anthocyanins ; leaf coloration ; directional improvement ; YABBY ; pineapple ; subcellular localization ; oak species identification ; Quercus ; mutation hotspots ; Centranthera grandiflora Benth ; transcriptome ; catalpol biosynthesis ; acteoside biosynthesis ; azafrin biosynthesis ; wheat ; Dasypyrum villosum ; alien substitution line ; GISH ; molecular marker ; marker-assisted selection ; regulation ; RNA-seq ; biosynthesis pathway ; chalcones ; stilbenes ; common bean ; Fusarium oxysproum ; plant–pathogen interaction ; metabolome ; evolution ; genome fractionation ; ABC transporters ; transcription factors ; transposable elements ; whole-genome duplication ; RNA-sequencing ; ChIP-sequencing ; transcriptional regulatory mechanism ; data integration ; karyopherin ; solanum tuberosum ; chemical fungicide ; disease control ; Neoscytalidium dimidiatum ; royal poinciana ; stem canker ; UAE ; bioinformatics ; VvGAST ; GASR ; Cis-elements ; wheat genome ; kernel hardness ; Puroindoline ; Puroindoline b-2 variants ; genotype-to-phenotype association ; synteny ; phylogenetic analysis ; genomic selection ; missing data ; minor allele frequency ; GDSL lipase ; GPAT6 ; cutin ; habaneros ; Capsicum chinense ; fruit ; RNA-Seq ; flax ; genome-wide association study (GWAS) ; single nucleotide polymorphism (SNP) ; prediction accuracy ; quantitative trait loci (QTL) ; quantitative trait nucleotides (QTNs) ; Fabaceae ; Lupinus ; glutamine synthetase (GS) ; phosphoenolpyruvate carboxylase (PEPC) ; gene families ; duplication/triplication ; structural genomics ; genome organization ; genome evolution ; microRNA ; miRNA156 ; seed development ; fatty acid synthesis ; linseed flax ; anthocyanin biosynthetic genes ; cis-regulatory motifs ; DEGs ; network analysis ; qRT-PCR ; reddish purple Chinese cabbage ; abscisic acid ; flavonolignans ; metabolite profiling ; Silybum marianum ; silymarin ; aquaporins ; bright yellow-2 suspension cells ; Nicotiana tabacum ; substrate specificity ; TaCKX1 ; TaCKX expression ; grain yield ; cytokinins ; phytohormones ; RNAi ; wheat spikes ; genome-wide identification ; 2OGD family ; hormone biosynthetic and metabolism genes ; tomato fruit ripening ; DNA methylation ; phenomics ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-24
    Beschreibung: The milk industry is largely based on dairy cattle production. After decades of great advancements in genetics, nutrition, and management, today, one cow can reach unprecedented levels of milk production. New challenges have been posed to preserving the health and welfare of these domestic animals. “High-Yielding Dairy Cows” is a collection of scientific papers focusing on three main areas: metabolic diseases, reproduction diseases, and herd (heath) management in confined and pasture production systems. This book aggregates knowledge from a molecular level to a more holistic approach on disease prevention and management, giving the reader an accurate overview of the current state of the art of this topic. It intends to contribute to ensuring the supply of ethical and responsible animal protein for about eight billion of people.
    Schlagwort(e): dairy cow ; fatty liver ; lipid metabolism ; oxidative stress ; SIRT1 ; dairy cows ; PPARγ ; non-alcoholic fatty liver disease (NAFLD) ; genetic factor ; dairy industry ; milking system ; work routine ; parlor ; milking model ; small dairy ; reproductive strategy ; parity ; season ; rank of AI ; type of AI ; heat stress ; whole transcript sequencing ; immune response ; stress response ; myostatin gene ; variation ; milk ; fatty acid ; cattle ; milk production ; metabolomics ; biomarkers ; flaxseed ; dry period ; enterolactone ; milk fatty acids ; peak of lactation ; lipolysis ; fatty acids ; casein ; postpartum diseases ; activin ; inhibin ; cytokines ; endometrium ; subclinical endometritis ; cow ; milk beta-hydroxybutyrate ; fat to protein content ratio ; left displaced abomasum ; negative energy balance ; alpha-tocopherol/vitamin E-related gene ; calving ; colostrum ; high-yield dairy cows ; inflammation ; health ; lactation ; liver ; mammary gland ; ultrasonography ; pregnancy proteins ; embryonic mortality ; fetal mortality ; body condition score ; urea ; β-hydroxybutyrate ; metabolism ; urea in milk ; primiparous cows ; lactation curves ; feeding system ; herd management ; protein metabolism ; amino acids ; milk protein ; Saccharomyces cerevisiae ; high-yield cows ; pH ; VFA ; inflammatory cytokines ; transition period ; ketosis ; RNA-Seq ; clustering ; liver metabolism ; Jersey ; oral calcium bolus ; calcium ; hypocalcemia ; mastitis ; culling ; reproduction ; herd health ; milking management ; production systems ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 51
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-06-23
    Beschreibung: Arthritis has a high prevalence globally and includes over 100 types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. All types of arthritis share common features of the disease, including monocyte infiltration, inflammation, synovial swelling, pannus formation, stiffness in the joints, and articular cartilage destruction. The exact etiology of arthritis remains unclear, and no cure exists as of yet. Anti-inflammatory drugs (NSAIDs and corticosteroids) are commonly used in the treatment of arthritis. However, these drugs are associated with significant side effects, such as gastric bleeding and an increased risk of heart attack and other cardiovascular problems. It is therefore crucial that we continue to research the pathogenesis of arthritis and seek to discover novel modes of therapy. This reprint summarizes the themes of the 29 articles published in our Special Issue “Research of Pathogenesis and Novel Therapeutics in Arthritis 2.0”. This reprint details important novel research discoveries that contribute to our current understanding of arthritis.
    Schlagwort(e): rheumatoid arthritis ; exercise therapy ; autoimmune disorder ; treadmill running ; exercise ; articular cartilage ; collagen-induced arthritis ; pro-inflammatory cytokine ; connexin 43 ; osteoporosis ; microenvironment ; inflammation ; mesenchymal stem/stromal cells ; bone injury ; repair/regeneration ; microparticles ; joint inflammatory diseases ; Wnt signaling ; Dkk-1 ; biologics ; ankylosing spondylitis ; axial spondyloarthritis ; bone homeostasis ; osteoarthritis ; aging ; PTOA ; gene expression ; RNA-seq ; cartilage degeneration ; scRNA-seq ; chondrocytes ; animal model ; pain ; melatonin ; angiotensin II ; arthritis ; bone erosion ; tumor necrosis factor ; renin-angiotensin system ; angiotensin II type 1 receptor ; psoriatic arthritis ; osteoclastogenesis ; miR-941 ; WNT16 ; polymorphism ; genetic predisposition ; mutation ; methotrexate ; interleukin ; targeted therapy ; interstitial lung disease ; subclinical involvement ; ACPA ; pulmonary function testing ; CPET ; surfactant protein D ; DLCO ; HRCT ; lymph node stromal cells ; tolerance ; autoimmunity ; citrullination ; macrophages ; PADI2 ; inflammatory cytokines ; adhesion ; apoptosis ; L5 ; macrophage foam cell ; CD11c expression ; atherosclerosis ; rheumatoid arthritis (RA) ; synovium ; cytokines ; HHV-7 ; PCR ; ELISA ; immunohistochemistry ; adipocyte ; infrapatellar fat pad ; anterior cruciate ligament ; cartilage ; whole transcriptome sequencing ; biomarker ; CRISPR/Cas9 ; miRNA ; genome editing ; autoimmune arthritis ; Nkx2-3 ; B cell activation ; Spondyloarthritis ; ankylosing arthritis ; interleukin-17 ; interleukin-23 ; tibial compression ; gut microbiome ; antibiotics ; LPS ; adults ; juvenile ; immune ; laser blood irradiation ; low-level laser ; systemic ; naïve rheumatoid arthritis ; CD4+ T-lymphocytes ; methotrexate response ; IFNγ, IL-17A ; STAT expression ; osteonecrosis ; taurine ; mitochondrial function ; glucocorticoid ; discoidin domain receptors 1 (Ddr1) ; osteoarthritis (OA) ; autophagy ; terminal differentiation ; Treg ; Th17 ; microRNA ; transcriptional factor ; JAK/STAT ; Janus kinase inhibitors ; cardiovascular system ; heart failure ; thromboembolic ; lipid profile disturbances ; treatment ; molecular mechanisms ; biomarkers ; prevention ; collagen triple helix repeat containing 1 ; CTHRC1 ; cartilage destruction ; fibroblast-like synoviocytes ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Sprache: Englisch
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  • 52
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-04-05
    Beschreibung: Adaptation to external changes is necessary for all cells to survive and thrive in diverse environments. Key to these responses are the MAPK-mediated signaling pathways, intracellular communication routes that sense stimuli at the cell surface, and are ubiquitous in all eukaryotic organisms. In the case of fungi, MAPKs mediate essential processes, such as adaptation to environmental stresses, morphology regulation, or developmental processes. First studied in the early nineties in Saccharomyces cerevisiae, the fungal cell wall integrity (CWI) pathway has proven to be a central MAPK-mediated signaling cascade conserved in the fungal kingdom. Cells need to sense cell wall-perturbing conditions and mount the appropriate salvage response. Understanding this CWI pathway-mediated compensatory mechanism is key for the development of cell wall-targeted antifungal therapies. Moreover, its functional roles go beyond the maintenance of this essential structure, reaching many other physiological aspects that have major implications in development or virulence.In this Special Issue, expert researchers in this relevant subject have contributed with seven reviews and eleven original articles to advance our understanding of the CWI pathway by covering different structural, regulatory, and functional aspects in distinct yeasts and filamentous fungi.
    Schlagwort(e): Wsc1 ; membrane sensor ; SMALP ; detergent-free extraction ; fluorescence correlation spectroscopy ; transmission electron microscopy ; 3D reconstruction ; fission yeast ; MAPK ; cell integrity pathway ; S. japonicus ; S. pombe ; protein kinase C ; Pmk1 ; dimorphism ; hyphae ; yeast ; cell wall integrity ; phosphorylation ; azoles ; clotrimazole ; cytokinesis ; actomyosin ring ; septum ; cell integrity ; fungi ; cell wall ; cell wall proteins ; signaling pathways ; stress tolerance ; mannoprotein ; budding yeast ; morphology ; CalMorph ; cell wall integrity (CWI) pathway ; PKC ; GTPases ; MAP kinase ; morphogenesis ; virulence ; pathogenesis ; Hrr25 ; Mec1 ; Tel1 ; Pkc1 ; hydroxyurea ; UV irradiation ; cell wall integrity (CWI) ; Mtl1 ; autophagy ; glucose ; mitophagy ; Saccharomyces cerevisiae ; histidine kinase ; Paracoccidioides ; paracoccidioidomycosis ; cell cycle ; Slt2 ; checkpoint ; DNA damage ; conjugation ; ploidy ; lysis ; Cell Integrity Pathway ; stress ; CWI pathway ; UPR ; glucosamine ; tunicamycin ; N-glycosylation ; cell wall integrity pathway ; MAPK substrate ; kinase assay ; fungal cell wall ; cysteine-rich domain ; PAN domain ; aromatic clusters ; filamentous fungi ; signaling pathway ; surface sensor ; mitogen-activated protein kinase ; plant pathogen ; application ; fungicide ; drug target ; culture ; productivity ; stress response ; screening ; transcription ; essential genes ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Sprache: Englisch
    Format: application/octet-stream
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  • 53
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-12-20
    Beschreibung: The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.
    Schlagwort(e): HM401-1281 ; H1-99 ; endometrial stromal cells ; endometrial cell ; uterine cancer ; regeneration ; stem cell markers ; RANK ; chronic endometritis ; small RNA sequencing ; HOXA10 ; Vitamin D ; PPP2R1A ; molecular marker ; translational research ; angiogenesis ; endometriosis ; oestradiol ; mtDNA mutations ; antioxidant response ; protein phosphatase ; SMAP ; circulating tumour cells (CTCs) ; circulating tumour DNA (ctDNA) ; estrogen dependent ; endometrial regeneration ; mesenchymal stem cells ; endometrial cancer ; niche ; gene expression ; phosphoinositide 3-kinase ; lncRNAs ; mitochondrial biogenesis ; inflammation ; preclinical studies ; miRNA ; orthoxenograft ; tight junction ; proliferation ; aromatase ; testosterone ; CRISPR/Cas9 ; endometrium ; developmental pathway ; PP2A ; avatar ; infertility ; prognosis ; gene editing ; kinase inhibitor ; implantation ; haploinsufficiency ; contrast-enhanced CT scan ; pathway ; dehydroepiandrosterone (DHEA) ; CTCF ; PIK3CB ; zinc finger ; ectopic stroma ; liquid biopsy ; type II endometrial carcinoma ; eutopic and ectopic endometrium ; preclinical models ; EDN1 ; uterine aspirate ; cell contacts ; tumour suppressor gene ; pathogenomics ; mitochondrial dynamics ; adult stem cells ; PIK3CA ; murine models ; menstrual cycle ; immunomodulation ; decidualisation ; breakdown ; bioluminescence imaging ; protein kinase ; macrophages ; adherens junction ; exosomes ; immunohistochemistry ; orthotopic xenograft model ; decidualization ; p110? ; deficit of complex I ; targeted therapy ; mesenchymal stem cell ; sulfatase ; TRP channels ; personalized medicine ; mitophagy ; miR-375 ; migration ; microRNA ; gap junction ; cancer ; LGR5 ; miR-139-5p ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFP Social interaction
    Sprache: Englisch
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  • 54
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: The development of new plant varieties is a long and tedious process involving the generation of large seedling populations for the selection of the best individuals. While the ability of breeders to generate large populations is almost unlimited, the selection of these seedlings is the main factor limiting the generation of new cultivars. Molecular studies for the development of marker-assisted selection (MAS) strategies are particularly useful when the evaluation of the character is expensive, time-consuming, or with long juvenile periods. The papers published in the Special Issue “Plant Genetics and Molecular Breeding” report highly novel results and testable new models for the integrative analysis of genetic (phenotyping and transmission of agronomic characters), physiology (flowering, ripening, organ development), genomic (DNA regions responsible for the different agronomic characters), transcriptomic (gene expression analysis of the characters), proteomic (proteins and enzymes involved in the expression of the characters), metabolomic (secondary metabolites), and epigenetic (DNA methylation and histone modifications) approaches for the development of new MAS strategies. These molecular approaches together with an increasingly accurate phenotyping will facilitate the breeding of new climate-resilient varieties resistant to abiotic and biotic stress, with suitable productivity and quality, to extend the adaptation and viability of the current varieties.
    Schlagwort(e): QH301-705.5 ; Q1-390 ; n/a ; GA2ox7 ; cabbage ; OsGPAT3 ; oleic acid ; OsCDPK1 ; nutrient use efficiency ; stem borer ; yellow-green-leaf mutant ; branching ; epigenetics ; NPK fertilizers ; particle bombardment ; stress tolerance ; overexpression ; glycine ; heat-stress ; bulk segregant RNA-seq ; Prunus ; protein-protein interaction ; AdRAP2.3 ; plant architecture ; waterlogging stress ; genes ; Cucumis sativus L. ; Flower color ; resistance ; Tobacco ; gynomonoecy ; drought stress ; Brassica oleracea ; starch biosynthesis ; Overexpression ; WUS ; agronomic traits ; Ghd7 ; the modified MutMap method ; cry2A gene ; light-induced ; gene expression ; breeding ; Heterodera schachtii ; ABA ; Green tissue-specific expression ; subcellular localization ; squamosa promoter binding protein-like ; transcriptome ; FAD2 ; As3+ stress ; metallothionein ; flowering ; bisulfite sequencing ; tomato ; quantitative trait loci ; Promoter ; marker–trait association ; DEGs ; cytoplasmic male sterile ; Rosa rugosa ; MADS transcription factor ; yield ; P. suffruticosa ; CYC2 ; common wild rice ; Actinidia deliciosa ; gene-by-gene interaction ; Aechmea fasciata ; hybrid rice ; soybean ; R2R3-MYB ; bread wheat ; BRANCHED1 (BRC1) ; linoleic acid ; differentially expressed genes ; complex traits ; transgenic chrysanthemum ; D-genome ; Brassica ; candidate gene ; SmJMT ; gene expression pattern ; RNA-Seq ; candidate genes ; leaf shape ; Brassica napus ; recombination-suppressed region ; anthocyanin ; WRKY transcription factor ; Idesia polycarpa var ; single nucleotide polymorphism ; bud abortion ; QTL ; reproductive organ ; transient overexpression ; Elongated Internode (EI) ; sugarcane ; abiotic stress ; Oryza sativa L. ; RrGT2 gene ; Hd1 ; cZR3 ; cytoplasmic male sterility (CMS) ; seed development ; tapetum ; near-isogenic line (NIL) ; phytohormones ; TCP transcription factor ; pollen accumulation ; Anthocyanin ; WRKY ; quantitative trait loci (QTLs) ; salt stress ; floral scent ; sucrose ; Ogura-CMS ; root traits ; endosperm development ; Zea mays L. ; sesame ; Bryum argenteum ; AP2/ERF genes ; transcriptional regulation ; WB1 ; haplotype block ; broccoli ; agronomic efficiency ; durum wheat ; gene pyramiding ; Oryza sativa ; genetics ; flowering time ; Cicer arietinum ; Hs1pro-1 ; endosperm appearance ; phenolic acids ; anther wall ; bromeliad ; genomics ; transgenic ; DgWRKY2 ; Clone ; yield trait ; flower symmetry ; partial factor productivity ; rice ; molecular breeding ; genotyping-by-sequencing ; Chimonanthus praecox ; nectary ; Salvia miltiorrhiza ; pollen development ; regulation ; ZmES22 ; genome-wide association study ; VIGS ; iTRAQ ; genome-wide association study (GWAS) ; ethylene-responsive factor ; starch ; molecular markers ; rice quality ; Chrysanthemum morifolium ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: miRNAs are small noncoding RNAs that control gene expression at the post-transcriptional level. It has been recognized that dysregulation of miRNAs reflects the state and function of cells and tissues, contributing to their dysfunction. The identification of hundreds of extracellular miRNAs in biological fluids has underscored their potential in the field of biomarker research. In addition, the therapeutic potential of miRNAs is receiving increasing attention in numerous conditions. On the other hand, many operational issues, including stability, delivery systems, and bioavailability, have yet to be resolved. In this dynamic field, biopharmaceutical companies are increasingly engaged, and ongoing clinical trials point to anti-miR and miR-mimic molecules as novel classes of molecules for upcoming therapeutic applications. This reprint aims to provide a broad overview of current knowledge on several outstanding issues and new opportunities offered by miRNAs in the treatment of diseases and as early diagnostic tools for next-generation medicine.
    Schlagwort(e): mi-RNA ; physical exercise ; gene expression ; stress ; head and neck cancer ; miRNA ; chemoresistance ; protocol ; systematic review ; hazard ratio ; patient survival ; up-regulation ; down-regulation ; microRNA ; circulating miRNA ; theranostic biomarkers ; chemosensitivity ; melanoma ; meta-analysis ; miRNAs ; microRNAs ; liver neoplasms ; angiogenesis ; cancer biomarkers ; transfection ; qRT-PCR ; plasma ; amplification efficiency ; EBV ; LMP1 ; nasopharyngeal cells ; expression profiling ; chronic low-grade inflammation ; inflammation-associated biomarkers ; overweight and obesity ; children/adolescents ; sex-related associations ; DNA copy number variation ; comparative study ; progenitor cells ; amniotic fluid ; leiomyoma ; myometrium ; divergent cell commitment ; linear dysregulation ; circulating microRNAs ; extracellular miRNA ; nasopharyngeal carcinoma ; miRNA-based diagnosis ; HNSCC ; tumor-suppressor ; miR-30e-5p ; FOXD1 ; TCGA ; cervical cancer ; non-coding RNAs ; diagnosis ; prognosis ; therapeutics ; regulation of gene expression ; alveolar epithelial type II cells ; type II pneumocytes ; ATII ; AECII ; flow cytometry ; autofluorescence ; pathway analysis ; TGF-beta ; homeostasis ; EMT ; RNA-based therapeutic ; personalized medicine ; translational medicine ; breast cancer ; diagnostics ; therapy response ; hepatitis C virus ; liver injury ; microRNA-192 ; microRNA-29a ; HCV genotype-3 ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 56
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-03-21
    Beschreibung: We would like to provide the scientists a set of studies entitled "Study of the Influence of Abiotic and Biotic Stress Factors on Horticultural Plants". The reprint book contains 12 papers about the influence of the stress factors on the plant growth and soil parameters. Authors descripted the impact of the biotic and abiotic stress factors (i.e., high, and low temperature, salt, inorganic pollutants such as salts, heavy metals, phosphite, as well as irrigation) on the physiological, biochemical, and anatomical changes occurring in the plants at the cellular, tissue, organ, and whole plant level. The subject of these studies were different plant species, i.e., watermelon, lettuce, kale, potato, grapevine, hops, orchid, strawberry, and boxwood. The ideas of the papers can be divided into five topics: (1) achieving better quality of plant material for food production by changes made in the growth conditions, metabolic and genetic modifications; (2) increasing the plant resistance to environmental stresses by application of exogenous compounds of different chemical character; (3) reducing plant stress caused by anthropogenic activity applying nonmodified and genetically modified plants; (4) mitigating drought stress by irrigation; and 5) the positive effect of plant growth-promoting microorganisms on horticulture plants performance during drought stress.
    Schlagwort(e): abiotic stress ; strawberry ; companion plants ; phytoremediation ; cold stress ; cold-responsive genes ; anti-oxidants ; proline ; malondialdehyde ; hormone profiling ; 5-aminolevulinic acid ; Buxus megistophylla ; chlorophyll fast fluorescence characteristics ; mineral nutrition ; urban road greening ; orchid ; transformed ecosystems ; fly ash ; metals ; adaptive responses ; water exchange ; leaf mesostructure ; photosynthetic pigments ; photosynthesis ; plant introduction ; grapevine ; maximum daily shrinkage ; daily increase ; stem water potential ; leaf relative water content ; signal intensity ; Humulus lupulus L. ; soil porosity ; soil bulk density ; liming ; hop ridges ; Vitis spp. ; piwi cultivars ; disease-resistant varieties ; malic acid ; ripening ; fruit composition ; downy mildew ; phosphite stress ; antioxidant enzyme ; hydrogen peroxide ; root morphology ; potato ; genotypes ; Brassica oleracea var. acephala ; short-term cold stress ; phytochemicals ; pigments ; antioxidant enzymes ; chitosan (CTS) ; lettuce ; salinity ; soluble sugars ; climate change ; drought stress ; biopreparations ; plant stimulation ; plant growth-promoting microorganisms ; watermelon ; rootstock ; gene expression ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Sprache: Englisch
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  • 57
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: Foamy viruses, currently referred to as spumaretroviruses, are the most ancient retroviruses as evidenced by traces of viral sequences dispersed in all vertebrate classes from fish to mammals. Additionally, infectious foamy viruses circulate in a variety of mammalian species including simian, bovine, equine, caprine, and feline. Foamy viruses have many unique features which led to the division of the retrovirus family into two subfamilies, the Orthoretrovirinae and Spumaretrovirinae. In vitro, foamy viruses have a broad host range and in vivo, human infections have been described due to cross-species transmission from infected nonhuman primates. Thus far, there are no reports of virus-induced disease in humans or in the natural host species. These unique properties of foamy viruses have led researchers to develop foamy viruses as gene therapy vectors to study virus–virus and virus–host interactions for identifying factors involved in virus replication, transmission, and immune regulation that could influence potential clinical outcomes in humans as well as for using endogenous foamy virus sequences in the analysis of host species evolution.
    Schlagwort(e): spumavirus ; feline illness ; proviral load ; neglected virus ; bovine foamy virus ; infectious clone ; particle release ; cell-free transmission ; foamy virus ; spumaretrovirus ; cross-species virus transmission ; zoonosis ; restriction factors ; immune responses ; FV vectors ; virus replication ; latent infection ; feline foamy virus ; epidemiology ; retrovirus ; Spumaretrovirus ; mountain lion ; Puma concolor ; ELISA ; protease ; reverse transcriptase ; RNase H ; reverse transcription ; antiviral drugs ; resistance ; simian foamy virus ; gibbon ; lesser apes ; co-evolution ; complete viral genome ; equine foamy virus ; isolation ; Japan ; sero-epidemiology ; reptile foamy virus ; endogenous foamy virus ; endogenous retrovirus ; ancient retroviruses ; co-speciation ; foamy virus-host interactions ; viral tropism ; infection ; kidney ; cats ; chronic kidney disease ; chronic renal disease ; integrase ; integration ; co-infections ; NHP ; pathogenesis ; zoonoses ; viral prevalence ; Neotropical primates ; free-living primates ; Brazil ; new world primates ; simian retrovirus ; BFV ; spuma virus ; model system ; animal model ; animal experiment ; miRNA function ; gene expression ; antiviral host restriction ; gene therapy ; in-vivo gene therapy ; hematopoietic stem and progenitor cells ; foamy virus vector ; pre-clinical canine model ; SCID-X1 ; innate sensing ; cGAS ; STING ; foamy viruses ; wild ruminants ; European bison ; red deer ; roe deer ; fallow deer ; seroreactivity ; inter-species transmission ; HSC ; gene marking ; FV gene transfer to HSCs ; gene therapy alternatives ; serotype ; high-throughput sequencing ; replication kinetics ; cytopathic effect ; reverse transcriptase activity ; miRNA expression ; virus-host-interaction ; miRNA target gene identification ; innate immunity ; ANKRD17 ; Bif1 (SH3GLB1) ; replication in vitro ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 58
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-11-17
    Beschreibung: Clear cell renal cell carcinoma is currently one of the most interesting areas of study in oncology. Despite the advances made in this field, this tumor continues to be a health problem of major concern in Western societies, seriously affecting public health services. Several characteristics of this tumor make it an exciting meeting point for translational collaboration between clinicians and basic researchers. Clear cell renal cell carcinoma is a paradigmatic example of inter- and intra-tumor heterogeneity from morphological, immunohistochemical, and molecular viewpoints. This tumor is also a good example to investigate the complexity of tumor/tumor and tumor/environment relationships from an ecological perspective. A deeper identification of the varied internal tumor self-organization through the specialization of cell clones and subclones as local invaders and metastasizers, on one hand, and the interactions of specific subsets of tumor cells with the local host microenvironment, on the other, will significantly enrich our knowledge of this neoplasm. Clear cell renal cell carcinoma is also a paradigmatic test bench for antiangiogenic and immune checkpoint blockage therapies. The refinement of these therapeutic tools administered alone or in combination is a hot issue in oncology, and several international trials are underway.
    Schlagwort(e): clear cell renal cell carcinoma ; prognosis ; plasma ; PD-1 ; PD-L1 ; renal cell carcinoma ; immune checkpoint inhibitors ; immune related adverse events (irAEs) ; thyroid ; cutaneous ; biomarker ; DNA methylation ; epigenetics ; kidney ; hypoxia ; tumor microenvironment ; SCD-1 ; oleic acid ; renal cancer ; sunitinib ; resistance ; miRNA ; transcriptome ; pathway analysis ; nivolumab ; tissue slice culture ; PD1 ; T-cells ; metastatic clear cell renal cell carcinoma ; first-line treatment ; immunotherapy ; tyrosine kinase inhibitors ; combinations ; single-cell RNA sequencing ; immune landscape ; cancer immunotherapy ; intra-tumoral heterogeneity ; inter-tumoral heterogeneity ; inter-metastatic heterogeneity ; renal cell cancer ; treatment resistance ; angiogenesis ; adjuvant therapy ; prediction model ; prognostic factor ; clear cell kidney cancer ; radiogenomics ; radiomics ; machine learning ; gene expression ; cystic tumor ; imaging ; magnetic resonance ; surgery ; ddPCR ; circulating miRNA ; diagnosis ; malignancy ; histomorphological features ; PBRM1 ; immunohistochemistry ; architectural patterns ; endothelial cells ; translational ; immune checkpoint inhibitor ; responsiveness ; molecular features ; multisite tumor sampling ; intratumor heterogeneity ; clear-cell renal cell carcinoma ; disease progression ; prognostic factors ; biomarkers ; RNA sequencing ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
    Sprache: Englisch
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  • 59
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-06-21
    Beschreibung: Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, rendering oncology well along the path to “personalised cancer medicine”. Thanks to developments in genetics, several mutations and gene rearrangements have been identified in patients with endocrine cancers (e.g., thyroid and adrenocortical carcinoma). In particular, each patient can be considered as a unique, individual one, with unique genetic information. The aim of this Special Issue is to offer an overview of exciting new research in the area of endocrine tumours may set the stage for an innovative personalised management and precision medicine modalities for individualised care.New affordable individual genomic analyses, as well as the opportunity to test new compounds in primary cells may allow a personalised management of patients with endocrine malignancies. This approach may improve the prediction of clinical outcome and therapeutic effectiveness, as well as help to avoid the use of ineffective drugs. However, further efforts are needed to obtain an adjustment of clinical management in patients with endocrine cancers that would rely solely or in great part on genetic information. This Special Issue includes basic, translational, and clinical papers on personalised medicine in endocrine malignancies (i.e., thyroid and adrenal), especially focusing on diagnostic and prognostic biomarkers, as well as novel drug targets or targeted treatments, including eventual clinical trials.
    Schlagwort(e): papillary thyroid cancer ; SUV PET/CT ; BRAF V600E ; immune checkpoint inhibitors (ICIs) ; ipilimumab ; nivolumab ; prolactinoma ; Cushing’s disease ; aggressive pituitary tumor ; aggressive PitNET ; aggressive pituitary adenoma ; pituitary carcinoma ; adrenocortical cancer ; adrenal adenomas ; adrenal tumors ; p53 ; p27 ; ki-67 ; reticulin ; mitotane ; adjuvant treatment ; recurrence ; recurrence free survival ; timing ; intratumoral heterogeneity ; thyroid tumor ; BRAF ; RET/PTC rearrangements ; RAS mutation ; adrenal cortex ; carcinoma ; angiogenesis ; gene expression ; osteopontin ; hyaluronan synthase 1 ; multikinase inhibitors ; sorafenib ; lenvatinib ; differentiated thyroid cancer ; radioiodine resistance ; predictive marker ; predictors ; response to treatment ; survival ; information needs and preferences ; focus group interview ; personalized medicine ; neuroendocrine tumours ; phaeochromocytoma ; paraganglioma ; molecular clusters ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 60
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: During the last few years, industrial fermentation technologies have advanced in order to improve the quality of the final product. Some examples of those modern technologies are the biotechnology developments of microbial materials, such as Saccharomyces and non-Saccharomyces yeasts or lactic bacteria from different genera. Other technologies are related to the use of additives and adjuvants, such as nutrients, enzymes, fining agents, or preservatives and their management, which directly influence the quality and reduce the risks in final fermentation products. Other technologies are based on the management of thermal treatments, filtrations, pressure applications, ultrasounds, UV, and so on, which have also led to improvements in fermentation quality in recent years. The aim of the issue is to study new technologies able to improve the quality parameters of fermentation products, such as aroma, color, turbidity, acidity, or any other parameters related to improving sensory perception by the consumers. Food safety parameters are also included.
    Schlagwort(e): QH301-705.5 ; Q1-390 ; TX341-641 ; low-ethanol wines ; wine-related fungi ; non-Saccharomyces ; yeasts ; narince ; wine quality ; tryptophol ; low ethanol wine ; serotonin ; non-conventional yeasts ; Bombino bianco ; Schizosaccharomyces pombe ; volatile compounds ; ethyl carbamate ; phthalates ; autochthonous ; meta-taxonomic analysis ; Pichia kluyveri ; pH control ; IAA ; Torulaspora delbrueckii ; chemical analyses ; aroma profile ; yeast ; enzymatic patterns ; wine flavor ; fermentation ; must replacement ; Saccharomyces cerevisiae ; malolactic fermentation ; wine ; HACCP ; food quality ; sequential inoculation ; alcoholic beverages ; itaconic acid ; biocontrol application ; white wine ; hydroxytyrosol ; tryptophan ; glucose ; kinetic analysis ; wine aroma ; amino acid decarboxylation ; lactic acid bacteria ; vineyard soil ; wine color ; tyrosol ; Saccharomyces ; Gompertz-model ; sequential culture ; biogenic amines ; SO2 reduction ; climate change ; Vineyard Microbiota ; A. terreus ; sulfur dioxide ; human health-promoting compounds ; Hanseniaspora guilliermondii ; non-Saccharomyces screening ; aromatic/sensorial profiles ; Malvar (Vitis vinifera L. cv.) ; probiotics ; Yeasts ; native yeast ; color ; glutathione ; hot pre-fermentative maceration ; technological characterization ; wine-related bacteria ; Riesling ; Torulaspora microellipsoides ; Lachancea thermotolerans ; Metschnikowia pulcherrima ; cashew apple juice ; resveratrol ; biocontrol ; shiraz ; Tannat ; ochratoxin A ; aroma compound ; trehalose ; wine composition ; Hanseniaspora uvarum yeast ; food safety ; acidity ; sensory evaluation ; viticulture ; melatonin ; alcoholic fermentation ; aroma ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: Explore a decade of groundbreaking research in "10th Anniversary of Cells—Advances in Plant, Algae, and Fungi Cell Biology." This reprint offers a comprehensive journey into the realms of plant, algae, and fungi cell biology. Delve into the world of genomics, cellular defense mechanisms, mycorrhizal fungi, and the physiology of extremophile algae. A celebration of scientific excellence, this reprint is a valuable resource for researchers, educators, and enthusiasts passionate about these fascinating domains. Join us in commemorating a decade of discovery and advancement in cellular biology.
    Schlagwort(e): membrane proteins ; overproduction ; production platform ; protein purification ; Saccharomyces cerevisiae ; solute carrier 39 ; SLC39 ; family ; yeast ; zinc ; zinc transporters ; ZIPs ; Agave americana ; crassulacean acid metabolism ; genetic engineering ; Nicotiana sylvestris ; phosphoenolpyruvate carboxylase ; photosynthesis ; drought tolerance ; salt tolerance ; microalgae ; Chlamydomonas reinhardtii ; starch ; supraoptimal temperature ; cell cycle ; pilot-scale production ; DNA methylation ; Fusarium graminearum ; in vitro subcultures ; virulence reduction ; ddRAD-MCSeEd ; virulence genes ; 13C ; 14C ; aldol ; Calvin-Benson cycle ; light respiration ; isotope labeling ; cytokinin ; endocytosis ; cytoskeleton ; actin ; plant immunity ; induced resistance ; Parachlorella kessleri ; supra-optimal temperature ; energy reserves ; growth processes ; reproduction events ; deuterium ; deuterated starch ; deuterated lipid ; soft scale insects ; Ophiocordyceps ; symbiosis ; transovarial transmission ; Verticillium wilt ; Glomus viscosum Nicolson ; arbuscular mycorrhizal fungi ; oxidative stress ; antioxidant systems ; defense ability ; ABI5 ; ABF ; AREB ; abiotic stress response ; abscisic acid ; phytohormone crosstalk ; salinity stress ; chloroplast ; plastid ; osmolytes ; osmotic adjustment ; reactive oxygen species ; herbivory ; membrane potential ; ion channel ; Arthrospira ; haloalkalotolerant cyanobacteria ; metagenomics ; phylogenomics ; fatty acid ; enveloped virus ; Ebola virus ; HIV ; herpes simplex virus ; human cytomegalovirus ; influenza virus ; MERS-CoV ; SARS-CoV-2 ; N-glycosite ; O-glycosite ; high-mannose glycan ; complex N-glycans ; Vicieae man-specific lectin ; T/Tn-specific lectin ; specific interaction ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 62
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: Orchids are fascinating, with attractive flowers that sell in the markets and an increasing demand around the world. Additionally, some orchids are edible or scented and have long been used in preparations of traditional medicine.This book presents recent advances in orchid biochemistry, including original research articles and reviews. It provides in-depth insights into the biology of flower pigments, floral scent formation, bioactive compounds, pollination, and plant–microbial interaction as well as the biotechnology of protocorm-like bodies in orchids. It reveals the secret of orchid biology using molecular tools, advanced biotechnology, multi-omics, and high-throughput technologies and offers a critical reference for the readers.This book explores the knowledge about species evolution using comparative transcriptomics, flower spot patterning, involving the anthocyanin biosynthetic pathways, the regulation of flavonoid biosynthesis, which contributes to leaf color formation, gene regulation in the biosynthesis of secondary metabolites and bioactive compounds, the mechanism of pollination, involving the biosynthesis of semiochemicals, gene expression patterns of volatile organic compounds, the symbiotic relationship between orchids and mycorrhizal fungi, techniques using induction, proliferation, and regeneration of protocorm-like bodies, and so on. In this book, important or model orchid species were studied, including Anoectochilus roxburghii, Bletilla striata, Cymbidium sinense, Dendrobium officinale, Ophrys insectifera, Phalaenopsis ‘Panda’, Pleione limprichtii.
    Schlagwort(e): Phalaenopsis ; transcriptome ; microRNA ; anthocyanin biosynthesis ; molecular mechanism ; coelonin ; Bletilla striata ; anti-inflammation ; signal pathway ; cell-cycle arrest ; PTEN ; Dendrobium officinale ; PLP_deC ; bioinformatics ; expression pattern analysis ; evolution ; Pleione limprichtii ; flower color polymorphism ; variation within populations ; metabolome analysis ; anthocyanin biosynthetic pathway ; RNA sequencing ; transcription factor ; Dendrobium ; molecular identification ; endophytic fungi ; pathogenicity ; protocorm ; seedling ; Anoectochilus roxburghii ; Ceratobasidium sp. ; metabolome and transcriptome analyses ; flavonoid ; HPLC-MS/MS ; qRT-PCR ; Ophrys ; sexual deception ; semiochemicals ; fly orchid ; pollination ; comparative transcriptome ; active ingredients ; different tissues ; biotechnology ; breeding ; mass propagation ; Orchidaceae ; protocorm-like bodies ; somaclonal variation ; somatic embryogenesis ; Cymbidium ; floral scents ; volatile organic compounds ; metabolomic analysis ; differential metabolites ; enzyme activity ; gene expression ; leaf color ; Cymbidium sinense ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 63
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-09-11
    Beschreibung: Plants under natural conditions often face multiple stresses, including drought, salinity, temperature extremes, submergence stress, bacteria, viruses, fungi, insects, etc. These biotic and abiotic stresses negatively influence plant growth and productivity. Various approaches have recently been used to overcome stresses in plants. It is necessary to evaluate and explore how diverse molecular techniques can be applied to different biological studies to improve biotic and abiotic stress tolerance in plants. This will help reduce production losses and increase crop tolerance to various stresses. It is now the time to make a difference by developing plants that can withstand biotic and abiotic stresses.
    Schlagwort(e): antioxidants ; drought ; oxidative stress ; pearl millet ; redox implications ; ROS ; chlorophyll fluorescence efficiency ; photosynthetic responses ; enzyme activity ; sugarcane ; smut ; circadian clock ; reactive oxygen species ; Al-induced PCD ; photoperiodism ; peanut ; phylogenetic ; virus-induced gene silencing ; transgenic lines ; physiological and biochemical analysis ; Glycine max L. ; PR proteins ; chitinase ; genome-wide ; plant stresses ; crop residues ; profitability ; soil fertility ; soil biology ; allelopathy ; heat shock protein 20 ; maize ; abiotic stress ; yeast-one-hybrid ; abiotic stresses ; cotton ; hormones ; signaling pathway ; WRKY ; papaya (Carica papaya) ; brassicales ; late embryogenesis abundant protein ; orthogroup ; expression profile ; artificial light ; auxins ; chicory ; callus cells ; inulin ; plant growth regulators ; milk thistle ; secondary metabolites ; ecotypes ; salinity ; growth attributes ; biotic stress ; phenolic compounds ; seaweed ; Dendrobium catenatum ; lipase ; multi-omics ; expression pattern ; gene family ; bio-fertilizer ; ionic homeostasis ; organic amendments ; vermicompost ; cold stress ; PKS5 ; stomatal aperture ; microbiota ; natural farming ; physical factors ; physiological changes ; signal transduction and stressed conditions ; Rhizobium leguminosarum ; PGPR ; Triticum aestivum L. ; cadmium stress ; tolerance ; ascorbate ; glutathione ; malondialdehyde ; chlorophylls ; disease gradient ; disease outbreak ; Puccinia ; wheat stripe rust ; plant epidemic ; dispersal ecology ; alternative plant vitrification solution ; ammonium-free medium ; cytotoxicity ; droplet-vitrification ; endangered species ; liquid overlay ; regrowth medium ; within-plant phenotypic plasticity ; combined stresses ; additive ; antagonistic and synergic effects ; VOCs ; potassium ; soybean ; water logging ; yield ; non-thermal plasma ; plant defense ; glucosinolates ; nitriles ; RNA sequencing ; Arabidopsis thaliana ; Bt toxins ; Cry1Ah1 transgenic poplar ; ecology ; environment ; rhizosphere ; candidate genes ; drought tolerance ; crop improvement ; climate change ; adaptation ; Chenopodium quinoa Willd. ; genotypes ; Sahara ; Algeria ; chitosan ; pathogen ; sustainable ; plant protection ; tomato ; melatonin ; photosynthesis ; climate changes ; antioxidant system ; Malus seedlings ; NaCl treatments ; membrane damage ; osmotic regulation ; archives ; botanical collection ; Greece ; landscape ; pre-rebellion period ; wheat ; priming ; Aspergillus niger ; qRT-PCR ; wilting ; TLP ; β-1,3-glucanase ; biostimulants ; biofertilizers ; soil microorganisms ; phytostimulator ; jewel sweet potato ; shoot tip ; axillary bud ; different MS salts concentration ; micropropagation ; plant performance ; C4 species ; heterozygosity ; transient soil salinity ; soil layers ; desertification ; arid regoins ; total flavonoid ; phenolics ; antioxidant activity ; centella ; Na+ content ; molecular markers ; MAS ; oilseeds ; SSRs ; molecular breeding ; dehydration-responsive element binding (DREB) transcription factors ; gene expression ; mosses ; stress tolerance ; common centaury ; salinity stress ; antioxidative protection ; sodium nitroprusside ; proteomic analysis ; drought stress ; sorghum ; RNS ; RSS ; signaling ; post-translational modification ; microorganisms ; stressful conditions ; sustainability ; nutrition ; Brassicaceae ; Cicer arietinum L. ; chlorophyll a fluorescence transient ; physiological and biochemical traits ; high temperature ; chocolate spot disease ; Botrytis fabae ; faba bean ; antioxidant enzymes ; protein banding and anatomy ; actinobacteria ; Streptomyces tuirus ; chilli fruit rot ; Colletotrichum scovillei ; Colletotrichum truncatum ; Fusarium oxysporum ; liquid bio-formulation ; corn smut ; fungus infection ; MDA ; proline ; quality ; halophytes ; Tripolium pannonicum ; hydrogen peroxide ; cell wall extensibility ; cell wall polysaccharide ; coleoptile ; growth inhibition ; lead (Pb) ; rice ; Bactrocera oleae ; spinosad ; kaolin ; organic oliviculture ; chlorophyll fluorescence ; leaf gas exchange ; physiological traits ; BAG (Bcl-2-associated anthanogene) family proteins ; molecular chaperone ; metabolomics ; metabolic responses ; metabolites variation ; surveillance ; Candidatus Liberibacter asiaticus ; comprehensive control ; distribution ; screen house ; Copper hyperaccumulation ; stress mitigation ; EDTA and IAA ; sunflower ; Fusarium wilt ; conventional breeding ; molecular makers ; QTLs ; genomics ; transcriptomics ; metabolomics and proteomics ; bread wheat ; AMF ; zinc ; growth parameters ; osmolyte ; osmoprotector ; ionic attributes ; PGPBs ; growth-promoting fungi ; crop productivity ; plant tolerance ; arbuscular mycorrhizal fungi ; aerobic rice ; soil enzymes ; phosphorus utilization ; P-deficient ; plant growth promotion ; chickpea ; selection indices ; drought tolerant genotypes ; abiotic and biotic stress ; CRISPR ; mega nucleases ; TALEN ; ZFN ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 64
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: Dive into the fascinating world of photosynthesis through the latest publications. This comprehensive work delves deep into the intricate regulatory mechanisms that underpin the vital process of photosynthesis. From the molecular reactions at the core to the overarching responses of entire plants, explore the diverse facets of this fundamental phenomenon. Discover how plants adeptly adapt to an ever-changing and often challenging environment. Gain valuable insights with real-world applications, spanning agriculture, forestry, and biotechnology. Whether you're a scientist, educator, or enthusiast, this reprint promises to unravel the mysteries of life's essential processes. Join us in this exploration of photosynthesis as we bridge the gap between scientific inquiry and practical knowledge, ensuring a sustainable future for both natural ecosystems and cultivated environments.
    Schlagwort(e): abiotic stressors ; environmental stress ; growth ; light intensity ; photosynthetic pigments ; picocyanobacteria ; plant physiology ; Alternaria brassicicola ; chlorophyll a fluorescence ; chloroplast ultrastructure ; defense response ; microarray ; photosynthesis ; susceptibility ; chlorophyll fluorescence ; extremely low frequency magnetic field ; Schumann resonance frequencies ; photosynthetic light reactions ; non-photochemical quenching ; quantum yield of photosystem II ; wheat ; pea ; endophytes ; culture filtrate ; exogenously hormone ; Phaseolus vulgaris ; antioxidant enzymes ; antioxidants ; carotenoids ; photochemical efficiency ; protein ; tocopherol ; xanthophyll cycle ; zeaxanthin ; root ; rhizosphere ; rhizobacteria ; root morphology ; abiotic stresses ; phase-sensitive imaging ; magnetopriming ; UV exclusion ; leaf venation ; leaf hydraulics ; high light ; thylakoid membrane ; microdomains ; photoprotection ; Synechocystis ; photoinhibition ; photosystems ; seed priming ; nanotechnology ; germination ; seed resistance ; sustainability ; cold plasma technology ; machine learning ; proton gradient regulation 5 (PGR5) ; PGR5-like photosynthetic phenotype 1 (PGRL1) ; photosynthetic electron transport ; PSI photoinhibition ; oxidation of P700 ; oxidative stress ; combined effect ; Pisum sativum L. ; nanoparticles ; cerium oxide ; zinc oxide ; metal uptake ; hydroponic culture ; photomorphogenesis ; Pinus sylvestris ; light of various spectral composition ; gene expression ; pigment content ; lipid droplets ; microalgae ; Raman spectroscopy ; Surface-enhanced Raman Spectroscopy ; cyanobacteria ; heavy metals ; nitrogenase ; heterocyst ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 65
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-11-30
    Beschreibung: Chronic immune-mediated inflammatory diseases (IMIDs), usually accompanied by cardiovascular disease and neoplasias, are now prevailed worldwide. The limited efficacy of current therapeutics and a proportion of non-responders are linked to missing aspects in their pathophysiology at the molecular and cellular levels. High-throughput single- and multi-omics approaches and their combinations are expected to pinpoint the key players underlying IMIDs’ establishment and/or progression, thus suggesting potential therapeutic targets and biomarkers. This Reprint gathered 13 papers presenting recent relevant data related to the assessment of CVD risk in RA, tailored therapeutics in RA-interstitial lung disease, IgG4-related RA, and Sjögren’s syndrome, enabling early identification of PsA and improving outcomes in patients’ with psoriasis. Also, novel non-invasive biomarkers for endoscopic activity and mucosal healing in ulcerative colitis, IBD, and cell-death-associated inflammatory syndromes are proposed. Moreover, a certain subset of telocytes is suggested as the pilot governor of epithelial behavior in preneoplastic gastric lesions, a newer member of IL-1 family, as it is a critical partner in lung adenocarcinoma, while distinct transcriptomic signatures and pathway profiles in human melanocytes corresponding to different Staphylococcal superantigenic enterotoxins are possible targets for therapeutic intervention in cases of toxic shocks. Lastly, Tregs- and dendritic cell-based IMID biomarkers are recommended to enable at more efficient, personalized, and precise treatment strategies.
    Schlagwort(e): arthritis ; rheumatoid ; immunoglobulin G ; immune system ; inflammation ; proteins ; proteomics ; rheumatoid arthritis ; periodontal disease ; cardiovascular disease ; biomarker ; ulcerative colitis ; gelsolin ; mucosal healing ; interstitial lung disease ; biomarkers ; treatment ; superantigens ; gene expression ; transcriptional dynamics ; staphylococcal enterotoxins ; SEB ; SEA ; TSST-1 ; toxins ; biological networks ; clustering ; functional pathways ; time–course analysis ; cDNA microarray ; human melanocytes ; cell death ; apoptosis ; necroptosis ; pyroptosis ; ubiquitin ; LUBAC ; OTULIN ; A20 ; autoimmunity ; human genetics ; epigenetics ; endoscopy ; imaging ; laboratory testing ; Sjogren’s syndrome ; patient stratification ; clinical relevance ; multi-omics ; psoriasis ; methylation ; histone ; ncRNAs ; immune-mediated inflammatory disorders ; autoimmune diseases ; immune regulation ; dendritic cells ; regulatory T cells ; omics ; therapeutic targeting ; chronic inflammation ; psoriatic diseases ; psoriatic arthritis ; data integration ; interleukin (IL-)37 ; lung adenocarcinoma ; survival ; infiltration rates ; FoxL1+-telocytes ; epithelial–mesenchymal interaction ; BMP signaling ; extracellular matrix ; mechanical microenvironment ; matrisome ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 66
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-02-20
    Beschreibung: This book presents the latest advances in assisted reproductive technologies applied to ruminants, such as multiovulation, artificial insemination, embryo transfer, and in vitro fertilization (IVF), which have been useful tools to accelerate the genetic progress in these species. The reader will find detailed studies on bisons, bovines, and goats
    Schlagwort(e): sperm viability ; embryo production ; fertilization ; blastocyst ; caprine ; COC ; IVF ; IVP ; IVEP ; oocyte competence ; photoperiod ; reproductive efficiency ; season ; seasonal breeder ; HSP70 ; heat stress ; in vitro embryos ; gene expression ; cattle ; Holstein ; Mediterranean Water Buffalo ; in vitro embryo production ; laparoscopic ovum pickup ; accelerated genetic gain ; prepubertal ; embryo development ; wisent ; European bison ; oocytes ; sperm ; embryos ; embryo transfer ; germplasm bank ; threatened species ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFZ Animals & society
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  • 67
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-31
    Beschreibung: Brown algae comprise approx. 2040 species grown in various climatic conditions. They represent a reservoir of various bioactive compounds, including fucoidan, alginate, phlorotannins, and fucoxanthins. They have shown an array of applications in pharmaceutical and medical fields. Hence, the Guest Editor invites all interested authors to submit their contributions to the current issue in Marine Drugs entitled “Bioactive Compounds from Brown Algae”. It aims to highlight different aspects of bioactive compounds found in brown algae, in either research or review articles. Specifically, we are interested in downstream processes, chemistry, biotechnology, and applications of, for example, heteropolysaccharides and other brown algae bioactives. In addition, the structure elucidation and enzymatic modification of these components are also within the scope of the present Issue.
    Schlagwort(e): hepatic steatosis ; lipogenesis ; seaweed ; polyphenol ; fucoidans ; fucoidanases ; glycosidic linkages ; molecular masses ; NMR ; structure–activity relationships ; fucoidan ; cancer ; VEGF ; gene expression ; toxicity ; Dictyosiphon foeniculaceus ; retinal pigment epithelium ; glioblastoma ; astrocytes ; uveal melanoma ; 7-phloro-eckol ; HepG2/CYP2E1 cells ; oxidative stress ; apoptosis ; anti-lung cancer ; brown algae ; human lung carcinoma A-549 cells ; oversulfation ; Sargassum aquifolium ; phlorotannins ; antifungal ; larvicidal ; brown seaweeds ; biological activities ; anti-inflammatory ; antioxidant ; coastal area ; crude lipid extract ; Sargassum ilicifolium ; gut microbiota ; bioaccessibility ; short-chain fatty acids ; prebiotics ; gastrointestinal tract ; noise ; hearing loss ; dieckol ; PFF-A ; alginate ; laminarin ; bioactivity ; thema EDItEUR::M Medicine and Nursing
    Sprache: Englisch
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  • 68
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-12-21
    Beschreibung: Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.
    Schlagwort(e): R5-920 ; RM1-950 ; receptor activator of nuclear factor ?B ; infliximab ; tripterine ; triptolide ; osteoblast ; tumor necrosis factor-alpha ; synovial cell ; anti-arthritis ; biosimilars ; Epstein-Barr virus ; cytokines ; SOX9 ; parathyroid hormone ; nitric oxide ; rat ; etanercept ; angiogenesis ; glycosylation ; mitogen activated protein kinase ; Th9 lymphocytes ; rheumatoid arthritis ; IL-6 ; clodronate ; bone erosion ; mesenchymal stem cells ; collagen-induced arthritis ; biological ; gene expression ; inflammatory arthritis ; osteoarthritis ; fraxinellone ; nuclear factor kappa B ; messenger RNA ; inflammation ; miRNA ; disease-modifying ; adipokines ; WNT ; glycoprotein 42 ; miR-199a-5p ; proliferation ; next-generation sequencing ; collagen ; osteoarthritis (OA) ; experimental arthritis ; bone morphogenetic protein ; TNF-? ; computational modeling ; basic research ; osteoclast ; therapeutics ; certolizumab pegol ; chondrocytes ; progenitor cells ; adjuvant arthritis ; adalimumab ; triterpenoid ; sclareol ; TNF? ; fibroblast growth factor 2 ; antibodies ; osteoblasts ; molecular pathology ; Th17 ; immunology ; obesity ; visfatin ; articular cartilage ; autoimmune ; biomarkers ; celastrol ; MAPK ; disease pathways ; IL1? ; arthritis ; bioinformatics ; anticitrullinated peptide antibodies ; drug delivery system ; antagonists ; shared epitope ; pathology ; SMA- and MAD-related protein ; small-molecule inhibitor ; transforming growth factor ? ; mice ; golimumab ; spinal fusion ; antirheumatic drug ; early osteoarthritis ; stem cell ; rheumatoid factor ; therapeutic antibody ; bisphosphonate ; osteoclastogenesis ; interleukin ; spondyloarthropathies ; clinical translation ; therapy ; Traditional Chinese medicine ; chemokines ; structure ; cell signaling ; microRNA ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 69
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-09
    Beschreibung: Yeasts are truly fascinating microorganisms. Due to their diverse and dynamic activities, they have been used for the production of many interesting products, such as beer, wine, bread, biofuels and biopharmaceuticals. Saccharomyces cerevisiae (bakers’ yeast) is the yeast species that is surely the most exploited by man. Saccharomyces is a top choice organism for industrial applications, although its use for producing beer dates back to at least the 6th millennium BC. Bakers’ yeast has been a cornerstone of modern biotechnology, enabling the development of efficient production processes for antibiotics, biopharmaceuticals, technical enzymes, and ethanol and biofuels. Today, diverse yeast species are explored for industrial applications, such as e.g. Saccharomyces species, Pichia pastoris and other Pichia species, Kluyveromyces marxianus, Hansenula polymorpha, Yarrowia lipolytica, Candida species, Phaffia rhodozyma, wild yeasts for beer brewing, etc. This Special Issue is focused on recent developments of yeast biotechnology with topics including recent techniques for characterizing yeast and their physiology (including omics and nanobiotechnology techniques), methods to adapt industrial strains (including metabolic, synthetic and evolutionary engineering) and the use of yeasts as microbial cell factories to produce biopharmaceuticals, enzymes, alcohols, organic acids, flavours and fine chemicals, and advances in yeast fermentation technology and industrial fermentation processes.
    Schlagwort(e): coffee processing ; coffee fermentation ; starter culture ; coffee beverage ; yeast ; Icewine ; Saccharomyces cerevisiae ; hyperosmotic stress ; CRISPR-Cas9 ; glycerol transport ; STL1 ; brewing ; Cyberlindnera ; NABLAB ; non-alcoholic beer ; non-conventional yeast ; non-Saccharomyces yeast ; response surface methodology ; Ustilago ; itaconic acid ; process improvement ; lignocellulosic feedstock ; yeasts ; grape ; federweisser ; wine ; microbiota identification ; MALDI-TOF MS Biotyper ; Torulaspora delbrueckii ; craft beer ; microbrewery plant ; mixed fermentation ; aroma profile ; strain collection ; aroma profiling ; gas chromatography ; wine yeast ; Saccharomyces ; fermentation ; volatile aroma compounds ; Simultaneous inoculation ; Alcoholic fermentation ; Malolactic fermentation ; Sacccharomyces cerevisiae ; Oenococcus oeni ; PN4TM ; OmegaTM ; Aroma profile ; antioxidant ; coffee ; W. anomalus ; industrial brewer’s strains ; adaptive laboratory evolution (ALE) ; snowflake phenotype ; beer fermentation ; wine yeasts ; lactic acid bacteria ; co-inoculation ; sequence inoculation ; flavor compounds ; color pigments ; cell printing ; piezoelectric dispensing ; GFP-tagged yeast clone collection ; living cell microarrays ; microfluidic chip ; dynamic single-cell analysis ; Candida albicans ; adhesion ; fibronectin ; nanomotion ; atomic force microscope (AFM) ; xylose metabolism ; genetic engineering ; biofuel ; Spathaspora passalidarum ; Pichia stipitis ; volatile organic compounds ; proton-transfer reaction-mass spectrometry ; Metschnikowia pulcherrima ; flavor ; non-Saccharomyces yeasts ; fermentation-derived products ; fermented beverages ; beer ; coffee bean fermentation ; itaconic acid production ; bioethanol production ; bioreactors ; yeast micro- and nanobiotechnology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 70
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-03-07
    Beschreibung: In the study of head and neck squamous cell carcinoma (HNSCC), we know that virally induced malignancies behave differently than those generated through other carcinogenic mechanisms. This paradigm extends into differences in tumor growth, treatment response and resistance, as well as invasion and metastasis. The inability to correctly diagnose and appropriately treat HNSCC at early stages has contributed to reduced survival for HNSCC patients, particularly those with HPV-negative disease. The examination of the molecular differences between HPV-positive and HPV-negative HNSCC will provide support for early diagnostic markers and guide appropriate treatment selection to improve patient care and survival.This Special Issue highlights current research efforts to understand the evolving contribution of human papillomavirus in HNSCC.
    Schlagwort(e): head and neck cancer ; human papillomavirus ; oropharyngeal cancer ; virus-related cancers ; human papillomavirus diagnosis ; sinonasal squamous cell carcinoma ; prevalence ; detection method ; anatomic subsite ; photodynamic therapy ; ER/mitochondrial photosensitizer ; paraptosis ; apoptosis ; autophagy ; HPV ; OPSCC ; tonsillar cancer ; survival ; OS ; DFS ; p16 ; recurrence ; cancer subtypes ; gene expression ; oropharynx ; HPV integration ; immune response ; keratinization ; TATI ; Human Papillomavirus (HPV) ; immune status ; hematological parameters ; radiotherapy ; oropharyngeal squamous cell carcinoma ; DNA methylation ; transposable elements ; overall survival ; head and neck squamous cell carcinoma ; extracellular vesicle ; proteomic ; oropharyngeal cancer (OPC) ; human papillomavirus (HPV) ; cancer stem cells (CSCs) ; CSC markers ; prognosis ; tumor heterogeneity ; positron emission tomography ; diffusion-weighted ; dynamic contrast-enhanced ; kinetic modeling ; fast exchange regime model ; community detection algorithm ; spin-glass model ; high-risk human papillomaviruses ; head and neck squamous cell carcinomas ; viral DNA integration ; PCR ; DIPS-PCR ; APOT-PCR ; WGS ; WES ; capture-based assay ; RNASeq ; FISH ; consequences of HPV integration ; p53 ; cancer ; glycolysis ; oxidative phosphorylation ; metabolism ; biomarkers ; staging ; TNM ; prognostic ; T regulatory lymphocytes ; FoxP3 ; Langerhans cells ; CD1a ; immune cells ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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  • 71
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: Viruses are microscopic agents that exist worldwide and are present in humans, animals, plants, and other living organisms in which they can cause devastating diseases. However, the advances of biotechnology and next-generation sequencing technologies have accelerated novel virus discovery, identification, sequencing, and manipulation, showing that they present unique characteristics that place them as valuable tools for a wide variety of biotechnological applications. Many applications of viruses have been used for agricultural purposes, namely concerning plant breeding and plant protection. Nevertheless, it is interesting to mention that plants have also many advantages to be used in vaccine production, such as the low cost and low risks they entail, showing once more the versatility of the use of viruses in biotechnology. Although it will obviously never be ignored that viruses are responsible for devastating diseases, it is clear that the more they are studied, the more possibilities they offer to us. They are now on the front line of the most revolutionizing techniques in several fields, providing advances that would not be possible without their existence. In this book there are presented studies that demonstrate the work developed using viruses in biotechnology. These studies were brought by experts that focus on the development and applications of many viruses in several fields, such as agriculture, the pharmaceutical industry, and medicine.
    Schlagwort(e): Bacteriophage ; Salmonella ; biocontrol ; comparative genomics ; phage diversity ; grapevine ; apple latent spherical virus vector ; virus-induced flowering ; reduced generation time ; breeding of grapevine ; virus elimination ; Newcastle disease virus ; reverse genetics ; vaccines ; infectious diseases ; cancer ; porcine epidemic diarrhea virus ; VLP ; chemokines ; pig ; vaccine ; SARS-CoV-2 ; COVID-19 ; phages ; CRISPR ; viruses ; prevention ; diagnosis ; treatment ; adeno-associated virus (AAV) vector ; jaagsiekte sheep retrovirus (JSRV) ; LTR ; enhancer ; transduction ; viral vaccines ; cancers ; COVID-19 vaccines ; self-replicating RNA vectors ; DNA-based vaccines ; RNA-based vaccines ; plant virus ; viroid ; viral vector ; virus-induced gene silencing (VIGS) ; CRISPR/Cas9 ; genome editing ; carotenoid biosynthesis ; circular RNA ; infectious bursal disease virus ; immunization ; recombinant Lactococcus lactis ; variant strain ; baculovirus ; insect cells ; bacmid ; Tn7 ; genome stability ; protein expression ; chikungunya virus ; VLPs ; bioreactor ; CRISPR/Cas systems ; viral vectors ; gene editing ; plant genome engineering ; viral resistance ; adeno-associated virus ; AAV ; cancer gene therapy ; prophage ; hydrothermal vent ; Hypnocyclicus thermotrophus ; lytic cassette ; Escherichia coli ; heterologous expression ; codon optimization ; codon harmonization ; expression vectors ; aspect ratio ; VNPs ; TMV ; PVX ; CPMV ; geminivirus ; theranostics ; CRISPR-cas9 ; clodronate ; macrophage ; gene therapy ; gene expression ; nanotechnology ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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  • 72
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: This Special Issue Book, “Marine Bioactive Peptides: Structure, Function, andTherapeutic Potential"" includes up-to-date information regarding bioactivepeptides isolated from marine organisms. Marine peptides have been found invarious phyla, and their numbers have grown in recent years. These peptidesare diverse in structure and possess broad-spectrum activities that have greatpotential for medical applications. Various marine peptides are evolutionaryancient molecular factors of innate immunity that play a key role in host defense.A plethora of biological activities, including antibacterial, antifungal, antiviral,anticancer, anticoagulant, endotoxin-binding, immune-modulating, etc., makemarine peptides an attractive molecular basis for drug design. This Special IssueBook presents new results in the isolation, structural elucidation, functionalcharacterization, and therapeutic potential evaluation of peptides found inmarine organisms. Chemical synthesis and biotechnological production of marinepeptides and their mimetics is also a focus of this Special Issue Book.
    Schlagwort(e): QH301-705.5 ; Q1-390 ; cone snail ; tilapia ; n/a ; animal models ; BRICHOS domain ; recombinant peptide ; calcium absorption ; plastein reaction ; antioxidant activity ; endothelial dysfunction ; C3a ; lung cancer ; invertebrate immunity ; identification ; zinc bioavailability ; NA-inhibitory peptide ; nuclear magnetic resonance (NMR) ; review ; ACE-inhibitory activity ; intestinal absorption ; hairtail (Trichiurus japonicas) ; DU-145 cells ; peptide ; crustacean ; venom duct ; Kalloconus ; drug design ; molecular symmetry ; arenicin ; ?-helix ; APETx2 ; conotoxins ; functional diversity ; docking ; conotoxin ; neuraminidase ; angiotensin II ; polychaeta ; influenza virus ; phylogeny ; gene expression ; host defense peptide ; Perinereis aibuhitensis ; anti-diabetic activity ; conopeptides ; SHRs ; Chlorella pyrenoidosa protein hydrolysate (CPPH) ; metastasis ; Caco-2 cell monolayer ; Nrf2 ; caco-2 cells ; HUVEC ; PYP15 ; sea cucumber ; decapeptide ; cytotoxic ; arenicin-1 ; marine peptides ; cell proliferation ; Conus ; Conus ateralbus ; self-production of hydrogen peroxide ; antimicrobial activity ; molecular dynamics ; machine learning ; tachyplesins ; ion channels ; gut microbiota ; Anthopleura anjunae oligopeptide ; signaling pathways ; half-fin anchovy hydrolysates ; NF-?B ; Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) ; antihypertensive effect ; QAGLSPVR ; antimicrobial peptides ; vasculogenic mimicry ; antibacterial ; ?-hairpin ; innate immunity ; transcriptome sequencing ; HIF-1? ; Gracilariopsis lemaneiformis ; function ; ACE-inhibitory peptide ; complement ; peptide-zinc complex ; structure-activity relationship ; multi-functional peptides ; cod skin ; adsorption ; Maillard reaction products ; molecular docking ; antibacterial peptide ; PI3K/AKT/mTOR signaling pathway ; Arenicola marina ; structure–activity relationship ; antimicrobial peptide ; Rana-box ; acid-sensing ion channel ; Neptunea arthritica cumingii ; apoptosis ; membrane damage ; proteolytic system ; toxin ; polyphemusins ; computational studies ; muscle ; oyster zinc-binding peptide ; abalone ; pain relief ; transport routes ; cytotoxicity ; dexamethasone ; cell death ; host?microbe relationship ; anti-LPS factor ; MMPs ; protein synthesis ; structure ; Pyropia yezoensis peptide ; cone snails ; chemical synthesis ; prostate cancer ; Ugr 9-1 ; myotube atrophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 73
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-08-12
    Beschreibung: This colligated Special Issue of Pharmaceutics on Precision Medicine: Applied Concepts of Pharmacogenomics in Patients with Various Diseases and Polypharmacy offers to the reader a series of articles that describe the concept of Precision Medicine, discuss its implementation process and limitations, demonstrate its value by illustrating some clinical cases, and open the door to new and more sophisticated techniques and applications.
    Schlagwort(e): fibromyalgia (FM) ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; microRNA ; miRNome ; pharmacogenomics ; pharmacoepigenomics ; SM2miR ; Pharmaco-miR ; repoDB ; ME/CFS Common Data Elements (CDEs) ; dihydropyrimidine dehydrogenase ; DPYD ; 5-fluorouracil ; fluoropyrimidine ; therapeutic drug monitoring ; orthotopic liver transplant ; busulfan ; glutathione S-transferase ; genetic polymorphism ; limited sampling strategy ; pharmacokinetics ; clinical pharmacogenetics ; pharmacogenetic testing ; adverse drug reactions ; genotype ; phenotype ; pharmacogene ; barriers to pharmacogenetics implementation ; Sub-Saharan Africa ; chronic low back pain (cLBP) ; genetics ; personalized treatment ; polymorphism ; CYP450 ; tacrolimus ; CYP3A5 ; liver transplant ; pharmacogenomic ; minority ; data collection ; drug ; biomarker ; pharmacogenetics ; pharmacogenetic test ; personalized medicine ; gene expression ; infliximab ; adalimumab ; ulcerative colitis ; Crohn disease ; inflammatory bowel disease ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
    Sprache: Englisch
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  • 74
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-06-21
    Beschreibung: Recently, there has been a dramatic increase in the use of DNA-derived data and innovative phenotyping to obtain insights into the causative genes underlying traits of agronomical interest or to characterize tree genetic resources. The latter, in particular, could represent an important source of genetic diversity that can be readily used to enhance the adaptability to limiting environmental factors and resistance to biotic stresses or to promote novel genotypes with improved agronomic traits. On the whole, the studies collected in this book report on tree crop biodiversity characterization that could provide the essential building blocks to ensure future improvements in production and quality, as well as for innovations in tree crop development and utilization.
    Schlagwort(e): Camellia sinensis ; genetic diversity ; population structure ; SSR ; bark phenotype ; bark scale ; Norway spruce ; resonance wood ; sonic tomography ; conifer adaptation ; phenotypic plasticity ; comparative proteomics ; stress response ; Hainan Province ; endemic species ; conservation ; codon usage ; sequence divergence ; phylogeny ; Acer ; sect. Platanoidea ; chloroplast genome ; structural variation ; phylogenetics ; nSSR ; cpDNA ; Magnoliaceae ; conservation genetics ; fragmentation ; agroforestry ; domestication ; Inga edulis ; amazon forest ; microsatellite markers ; Paeonia rockii (flare tree peony) germplasm accessions ; phenotypic traits ; EST-SSR markers ; chloroplast DNA sequences ; tree improvement ; evergreen oak ; phenotypic selection ; selection criteria ; seed orchard ; generalized value ; genetic differentiation ; natural regeneration ; cultivated population ; semi-domesticated population ; growth trait ; wood property ; cytosine methylation ; epimarker ; candidate gene ; gene expression ; color mutation ; pigment metabolism ; chlorophyll ; anthocyanin ; mutation mechanism ; RNA-seq ; Castanopsis × kuchugouzhui ; natural hybrid ; molecular identification ; chloroplast DNA sequence ; microsatellite ; Ilex species ; Aquifoliaceae ; morphological traits ; DNA C-value ; plastid genome ; S-genotyping ; S-locus ; P. communis ; P. pyrifolia ; P. amygdaliformis ; genetic structure ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 75
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-11
    Beschreibung: This Special Issue, “Biotechnology Applications of Microalgae”, is focused on the latest novel advances related to the production of different bioactive compounds from microalgae and their biotechnological use.
    Schlagwort(e): enzymatic activity ; fluid dynamics ; microalgae ; oxidative stress ; static magnetic fields ; violaxanthin ; reactive oxygen species ; ascorbic acid ; glutathione ; tocopherols ; phenolic compounds ; carotenoids ; thraustochytrids ; antioxidants ; saturated fatty acids ; polyunsaturated fatty acids ; transcriptomics ; sustainability ; industrial valorization ; carbon dioxide fixation ; biological activities ; phytosterol ; Saccharomyces cerevisiae ; Phaeodactylum tricornutum ; Sparus aurata ; β-glucans ; pulse feeding ; immune tolerance ; salt stress ; seawater cultivation ; Internet of Things ; proteomics ; blue light ; astaxanthin ; fatty acid ; heme ; cell wall ; salicylic acid ; fucoxanthin ; green consumption ; food consumption ; amino acids ; carbohydrates ; radical scavenging activity (RSA) ; RP-HPLC ; Chromochloris zofingiensis ; lutein ; CO2 aeration ; cGMP-dependent kinase ; biodiesel ; microalgal biotechnology ; natural antioxidants ; Yarrowia lipolytica ; Chlorella vulgaris ; growth ; fatty acids ; Spirulina ; healthcare ; space missions ; medicine applications ; microgravity effects ; humic substances ; microalgae cultivation ; hormetic effects ; increased nutrient availability ; improved protection against abiotic stress ; higher accumulation of bioactive ingredients ; enhanced microalgal productivity ; Dunaliella salina ; chlorpropham ; herbicide ; phytoene ; Nannochloropsis ; mixotrophy ; photobioreactors ; CHN analysis ; metabolomics ; bioassay ; cell death pathway ; autophagy ; antitumoral activity ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
    Sprache: Englisch
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  • 76
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: This reprint presents recent developments in the field of biological liquid–liquid phase separation (LLPS, also known as biomolecular condensation). LLPS and related biogenesis of various membraneless organelles (MLOs) and biomolecular condensates (BMCs) represent fundamental molecular mechanisms governing the spatio-temporal organization of the intracellular space. In fact, MLOs and BMCs, being liquid droplets, represent specific compartments within a cell that are not enclosed by a lipid membrane. Most biological LLPS processes are reversible, and many MLOs/BMCs exist transiently; they rapidly emerge when conditions are changed and rapidly disintegrate as soon as the original conditions are restored, thereby showing a characteristic “now you see me, now you don’t” behavior. Numerous MLOs/BMCs are found inside eukaryotic cells, where they exist as liquid droplets (or cellular bodies, puncta, etc.) in the cytoplasm, nucleoplasm, mitochondrial matrix, and stroma of chloroplasts. Furthermore, MLOs/BMCs are commonly observed in Archaea, bacteria, and, likely, viruses. MLOs/BMCs have numerous crucial functions, and their biogenesis is known to be controlled by various external factors and environmental cues, such as changes in temperature, pH, and ionic strength of the solution. All of these have garnered the close attention of many researchers to biological LLPS, MLOs, and BMCs.
    Schlagwort(e): Alzheimer’s disease ; amyloid aggregation ; lipid bilayer ; cholesterol ; time-lapse AFM imaging ; molecular dynamics ; liquid–liquid phase separation (LLPS) ; membraneless organelles ; phase-separated condensates ; human diseases ; liquid–liquid phase separation ; intrinsically disordered proteins ; proteins with low complexity ; P-body ; Nst1 ; polyampholyte domain ; aggregation-prone domain ; Saccharomyces cerevisiae ; membrane-less organelle ; nuclear speckle ; nucleolus ; phase separation ; chromatin organization ; nuclear condensate ; intrinsically disordered region ; transcription ; DNA damage repair ; super-enhancer ; quantitative imaging ; CTP synthase ; cytoophidium ; fluorescence recovery after photobleaching (FRAP) ; stimulated emission depletion (STED) ; Drosophila ; epithelium ; follicle cell ; ingression ; paramyxoviruses ; Hendra virus ; amyloid-like fibrils ; Taylor Dispersion Analysis (TDA) ; negative staining Transmission Electron Microscopy (ns-TEM) ; Polyethylene glycol (PEG) precipitation assays ; Congo Red ; Small-Angle X-ray Scattering (SAXS) ; actin ; actin polymerization ; actin-binding proteins ; coacervate ; membrane ; signaling proteins ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
    Format: application/octet-stream
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  • 77
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-10-25
    Beschreibung: Among gluten-related disorders, coeliac disease (CD) is the best-known one to date, a chronic immune-mediated enteropathy triggered by exposure to gluten in genetically predisposed individuals. It is a common disease, occurring at all ages and characterized by a wide spectrum of clinical manifestations, affecting any organ or tissue. The diagnosis rate of this pathology has increased in the last 10 years, so worldwide epidemiologic data are now available that show that CD is ubiquitous, with a prevalence of 1.4%, higher in female than male individuals. Currently, the only effective treatment for CD is strict and lifelong adherence to a gluten-free diet (GFD). However, CD research is changing rapidly due to the continuous advancing of knowledge. For this reason, the main goal of this Special Issue has been to address the existing knowledge gaps and help advance such important aspects as the pathophysiology, diagnosis, follow-up, and therapeutic options of this pathology. This Special Issue includes 12 peer-reviewed articles reporting on the latest research findings in and evidence related to CD. The published articles cover a range of topics central to CD and GFDs.
    Schlagwort(e): celiac disease ; relatives ; microbiota ; Saccharomyces cerevisiae ; Pseudomonas fluorescens ; Bacteroides caccae ; coeliac disease ; oral diseases ; oral prevention ; gingival bleeding ; sleep-related breathing disorders ; oral health ; enamel defects ; interceptive orthodontics ; data mining gluten free diet ; gluten proteins ; immunogenicity ; evidence-based practice ; case management ; treatment adherence and compliance ; anemia ; iron transporter ; IgA nephropathy ; tissue transglutaminase autoantibody ; tissue transglutaminase-targeted IgA deposits ; flow cytometry ; age ; sex ; lesion grade ; intraepithelial lymphocytes TCRγδ+ ; functional bowel disease ; gluten-free diet ; tissue biomarkers ; non-coeliac gluten sensitivity ; FODMAP diet ; dietitian ; rural health services ; gluten ; gliadin ; gluten immunogenic peptides ; non-dietary therapies ; gluten cross-contaminations ; dietary adherence ; vital gluten ; oat ; hidden gluten ; patients with CD ; symptoms ; gluten excretion urine ; gluten-free diet monitoring ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 78
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: This book includes a collection of eight original research articles and three reviews covering a wide range of topics in the field of kinetoplastids. In addition, readers can find a compendium of molecular biology procedures and bioinformatics tools.
    Schlagwort(e): trypanosomatids ; yeasts ; trypanosomatids genome ; cell cycle phases ; S-phase duration ; DNA replication ; replication origins ; neglected tropical diseases ; Leishmania ; Trypanosoma cruzi ; Trypanosoma brucei ; drug discovery ; in vitro models ; in vivo models ; genomics ; drug resistance ; Leishmania infantum ; proteome ; post-translational modifications (PTMs) ; proteogenomics ; mass spectrometry ; Retrotransposon Hot Spot (RHS) multigene family ; chromosome distribution ; recombination ; gene mosaic structure ; evolution ; nuclear protein ; Leishmania braziliensis ; reverse genetics ; CRISPR–Cas9 ; gene targeting ; phenotyping ; heat shock proteins ; Trypanosoma cruzi strain ; sequencing methods ; genome plasticity ; gene expression ; trans-sialidases ; mucins ; SENP ; Ulp2 ; SUMO ; CRISPR ; protease ; genome ; repeats ; 3′UTR ; multigenic family ; Leishmania donovani ; whole-genome sequencing (WGS) ; transcriptome ; artemisinin drug resistance ; Leishmania viruses ; phylogeny ; coevolution ; endosymbiont protozoan viruses ; transcriptome assembly ; transcriptional regulation ; ontology network ; co-expression network ; taxonomic analysis ; database contamination ; kleptoplastidy ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Sprache: Englisch
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  • 79
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: DNA is a rapidly developing vaccine platform for cancer and infectious and non-infectious diseases. Plasmids are used as immunogens to encode proteins to be further synthesized in vaccine recipients. DNA is mainly synthetic, ensuring enhanced expression in the cells of vaccine recipients (mostly mammalians). Their introduction into the host induces antibody and cellular responses. The latter are often more pronounced, and mimic the events occurring in infection, especially viral. There are a few distinct ways in which the vaccine antigen can be processed and presented, which determine the resulting immune response and which can be manipulated. Routinely, the antigen synthesized within the host cell is processed by proteasome, loaded onto, and presented in a complex with MHC I molecules. Processing can be re-routed to the lysosome, or immunogen can be secreted for further presentation in a complex with MHC II. Apart from expression, vaccination efficacy depends on DNA delivery. DNA immunogens are generally administered by intramuscular or intradermal injections, usually followed by electroporation, which enhances delivery 1000-fold. Other techniques are also used, such as noninvasive introduction by biojectors, skin applications with plasters and microneedles/chips, sonication, magnetofection, and even tattooing. An intense debate regarding the pros and cons of different routes of delivery is ongoing. A number of studies have compared the effect of delivery methods at the level of immunogen expression, and the magnitude and specificity of the resulting immune response. According to some, the delivery route determines immunogenic performance; according to others, it can modulate the level of response, but not its specificity or polarity. The progress of research aiming at the optimization of DNA vaccine design, delivery, and immunogenic performance has led to a marked increase in their efficacy in large species and humans. New DNA vaccines for use in the treatment of infectious diseases, cancer, allergies, and autoimmunity are forthcoming. This Special Issue covers various aspects of DNA vaccine development.
    Schlagwort(e): alphaviruses ; layered RNA/DNA vectors ; DNA vaccines ; RNA replicons ; recombinant particles ; tumor regression ; protection against tumor challenges and infectious agents ; ebola virus disease ; artificial T-cell antigens ; DNA vaccine constructs ; computer design ; gene expression ; immunogenicity ; DNA vaccine ; mRNA vaccine ; plasmid DNA ; in vitro transcribed mRNA ; immune responses ; formulations ; Cytolytic T Lymphocytes ; antibodies ; innate immunity ; adjuvants ; vaccine delivery ; plasmid ; cytolytic ; perforin ; bicistronic ; HCV ; HIV ; IL-36 ; adjuvant ; DNA ; Zika ; Epstein-Barr virus ; latent proteins ; LMP2 ; EBNA1 ; LMP1 ; HIV-1 ; enhancer element ; circovirus ; influenza ; immunization ; intranasal ; lipid ; flagellin ; BCG ; vaccine ; rBCG ; HTI ; T-cell ; AIDS ; clinical trial ; therapeutic vaccine ; hepatitis C virus (HCV) ; mesenchymal stem cells (MSC) ; modified MSC ; DNA immunization ; nonstructural HCV proteins ; immune response ; HCV vaccine ; myeloid derived suppressor cells (MDSCs) ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine::MBNS Epidemiology & medical statistics
    Sprache: Englisch
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  • 80
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-04-05
    Beschreibung: Sarcomas are a group of rare cancers that arise in connective tissues of the body. Surgical resection is pivotal for the management of locoregional disease. In locally advanced or metastatic disease settings, systemic therapy has an important role in the multidisciplinary management of sarcoma. Cytotoxic therapy has been the primary treatment for many years. However, recent advances in molecular pathogenesis, the investigation of the tumour microenvironment, changes in clinical trial design, and increased international collaboration have led to the development of histology-driven therapy. Furthermore, genomic profiling has highlighted that, while some sarcomas have complex karyotypes, others are driven by translocation, amplification, and mutation, representing targets for the development of novel therapies. Checkpoint inhibitors have been used as single agents or in combination in clinical sarcoma trials. This progress will move the therapeutic modality in sarcoma patients from the “one-size-fits-all” approach towards a more personalized therapeutic algorithm and better outcomes soon. In this Special Issue, we present original research and review articles highlighting novel therapeutic approaches in the treatment of sarcoma patients.
    Schlagwort(e): osteosarcoma ; survival ; prognosis ; age groups ; chemotherapy ; metastasis ; local recurrence ; TEM1 ; VEGFR-1 ; EGFR ; VEGFR-2 ; IGF-1R ; PDGFRα ; CD40 ; image guided surgery ; near-infra red fluorescence ; soft tissue sarcomas ; angiosarcoma ; paclitaxel ; pazopanib ; efficacy ; toxicity ; progression-free survival ; sarcoma ; radiotherapy ; neoadjuvant therapy ; hypofractionated radiotherapy ; thermotherapy ; hyperthermia ; incisional biopsy ; core needle biopsy ; sensitivity ; bone ; soft tissue ; LC3B ; ATG16L1 ; p62 ; M6PR ; PD-L1 ; CD8 ; notochord ; tumor endoprosthesis ; megaprosthesis ; periprosthetic joint infection ; revision surgery ; bone sarcoma ; extracellular acidosis ; tumour microenvironment ; tumour-associated stroma ; acid-sensing ion channels ; vacuolar-ATP-ase ; carbonic anhydrase IX ; acridine orange ; soft tissue sarcoma ; immune monitoring ; immunophenotyping ; cytokines ; immune checkpoints ; gene expression ; Angiosarcoma ; biomarkers ; tumor microenvironment ; immunotherapy ; next-generation sequencing ; whole transcriptome sequencing ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Sprache: Englisch
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  • 81
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-04-05
    Beschreibung: Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins. This largest amino acid serves as the precursor for the important endogenous indoleamines serotonin, N-acetylserotonin, and melatonin that act as neurotransmitters, neuromodulators, and neurohormones. Kynurenic acid is the most potent endogenous antiexitotoxic agent. Other highly relevant pathways of tryptophan are the reversible transamination to indole-3-pyruvate with formation related indolic acids that act as potent antioxidant agents. Tryptophan metabolites, such as melatonin, and structurally related agents, such as indole-3-propionic acid, act as potent catalytic antioxidants and bioenergetic agents that facilitate regeneration and protection against stress and aging. Several indole compounds act as uremic toxins since these agents can induce radical formation that is associated with enhanced oxidative stress and damage. The exploration of the effects of these protective and toxic tryptophan derived agents has revealed important molecular mechanisms and mediators of adaptation and aging. Research on tryptophan in nutrition and health can facilitate the development of new approaches to extend human health and life span. Amino acids are the building blocks of life that enable repair, as well as recycling and regeneration. Research on nutrients like amino acids, such as tryptophan and its metabolites, as well as peptides and proteins, or extracts containing this molecular metabolism modifiers can improve health. Research into the indololome is a new emerging and rapidly growing field of utmost relevance to science and society.
    Schlagwort(e): tryptophan ; kynurenine ; kynurenic acid ; FICZ ; AhR ; melanoma ; proliferation ; cell death ; aryl hydrocarbon receptor ; chronic kidney disease ; developmental origins of health and disease (DOHaD) ; hypertension ; indole ; melatonin ; serotonin ; uremic toxin ; virus ; immunity ; codon ; depression ; chronic mild stress ; oxidative stress ; tryptophan catabolites pathway ; methylation ; expression ; escitalopram ; 5-hydroxytryptophan ; natural sources ; microbial production ; biosynthetic pathways ; physiological effects ; animal ; human ; kynurenine pathway ; MEL biosynthesis ; Saccharomyces cerevisiae ; yeast ; tryptophan extraction ; LC-MS/MS ; soybean ; skin ; atopic dermatitis ; psoriasis ; severe acute respiratory syndrome ; SARS-CoV-2 ; COVID-19 ; malignant melanoma ; urine ; autofluorescence ; transplantation ; ischemia-reperfusion ; tolerance ; rejection ; indoleamine-2,3-dioxygenase ; L-tryptophan ; amino acids ; MAC-T cell ; proteomics ; omics ; β-casein ; mTOR ; systemic inflammation ; dysbiosis ; gut ; microbiota ; obesity ; mice ; tyrosine ; cytokines ; behavior ; inflammation ; liver morphology ; color ; cell culture media ; LC-MS ; antioxidant ; cytotoxicity ; biomanufacturing ; 5-hydroxytryptamine ; secretion ; metabolism ; nitrofurantoin ; antibiotics ; human serum albumin ; molecular interactions ; FTIR ; fluorescence ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Sprache: Englisch
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  • 82
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-11-17
    Beschreibung: This Special Issue focuses on the effects of hydrostatic pressure on biological systems and the use of these effects for exploring the structure, function, and molecular dynamics of biological macromolecules and their ensembles. Here, we present a selection of papers highlighting new experimental findings and new theoretical concepts in high-pressure biosciences. In these studies, the authors combine pressure perturbation approaches with NMR and optical spectroscopy, kinetic and thermodynamic techniques, functional genomics and transcriptomics, and molecular dynamics simulations to gain new insights into the conformational dynamics of proteins and nucleic acids and to better understand the mechanisms of high-pressure adaptation in piezophiles. The articles collected in this issue demonstrate the unique exploratory potential of the pressure perturbation approach for biochemistry, biophysics, mechanistic enzymology, and evolutionary biology.
    Schlagwort(e): protein folding ; NMR ; high hydrostatic pressure ; thermodynamic stability ; protein–ligand binding ; high pressure ; Martian salts ; perchlorate ; BSA ; ANS ; viroid ; hydrostatic pressure ; temperature ; structure–activity relationship ; RNA World ; n/a ; G-quadruplex ; i-motif ; volumetric properties ; pressure-temperature phase diagram ; thermodynamics ; hepatitis B ; DNA ; oligo ; FRET ; FTIR ; spectroscopy ; pressure ; volume change ; TMPyP4 ; deep-sea adaptations ; compressibility ; cavities ; potential energy landscape ; yeast ; Saccharomyces cerevisiae ; high-pressure response ; genetic manipulation ; transcriptomics ; piezophysiology ; Anfinsen’s dogma ; native state N ; unfolded state U ; fibril state F ; protofibrils ; hen lysozyme ; circular dichroism ; 1H NMR spectroscopy ; atomic force microscopy ; cytochrome P450 reductase ; conformational change ; pressure-perturbation spectroscopy ; protein hydration ; reduction kinetics ; stop-flow spectroscopy ; Sorghum bicolor ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
    Sprache: Englisch
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  • 83
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-10-25
    Beschreibung: In this Special Issue, we present the state of the art in the field of pig genetics and genomics, including the identification of gene candidates linked to important pig traits and to nutritional modifications, with the aim of collecting the most recent advances. The published manuscripts focused on high-throughput methodologies, such as RNA sequencing, ATAC-seq, MACE-seq, chip-seq, and RRBS, and covered other fields of pig genetics. The pig (Sus scrofa) is the most common large mammal in the world. The Sus genus includes domestic pig and wild boar. Since the draft reference genome sequence of S. scrofa was assembled in 2012, the processes of identification of genes related to important phenotypic traits and of search of genetic markers for pig selection have been significantly refined. In addition, the newest wide-range high-throughput techniques, including microarrays, next-generation sequencing, and the recent PacBio sequencing platform providing ultra-long sequencing reads, allow identifying gene mutations and gene candidates throughout the whole genome, transcriptome, or epigenome and estimating quantitative traits important for breeding as well as the genetic backgrounds of inherited diseases.
    Schlagwort(e): HMOX1 gene ; promoter ; transcriptional regulation ; Hezuo Tibetan pig ; AQP3 ; pig ; intramuscular fat ; adipogenesis ; proliferation ; litter size ; total number born alive ; SNP (single nucleotide polymorphism) ; GWAS (Genome-Wide Association Studies) ; heat stress ; Duroc ; RNA-Seq ; NMR ; metabolome ; fatness ; obesity ; extracellular matrix ; fat deposition ; lipid metabolism ; NGS ; genetically modified pigs ; genome modifications ; transgenic pigs ; genetic engineering ; disease models ; recombinant proteins ; xenotransplantation ; xenoantigen ; coagulation system dysregulation ; CRISPR/Cas9 system ; non-homologous DNA ends joining (NHEJ) ; TIDE analysis ; off-target ; skeletal muscle fiber ; meat quality ; metabolic diseases ; lncRNA ; RNA-seq ; porcine β-defensin 2 ; CRISPR/Cas9 ; antimicrobial peptide ; disease-resistant animals ; porcine alveolar macrophages ; DNMT3B ; DNA methylation ; isoform ; TNF-α ; pigs ; fatty acids ; 3′quant mRNA-seq ; nutrigenomics ; TRIM26 ; antiviral response ; IFN-β ; poly (I:C) ; VSV ; PRRSV ; seminal plasma ; endometrium ; global gene expression ; microarray ; alternative splicing ; transcript ; protein ; domain ; single nucleotide polymorphism ; hypothalamus ; puberty ; circRNAs ; pubertal genes ; Duroc pigs ; growth traits ; weighted single-step GWAS ; SNP ; gene expression ; congenital defects ; transcriptomics ; swine ; Sus scrofa ; precision medicine ; lymphatic system ; whole-genome sequencing ; SNP array genotyping ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSV Zoology & animal sciences
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  • 84
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: Computational fluid dynamics (CFD), which uses numerical analysis to predict and model complex flow behaviors and transport processes, has become a mainstream tool in engineering process research and development. Complex chemical processes often involve coupling between dynamics at vastly different length and time scales, as well as coupling of different physical models. The multiscale and multiphysics nature of those problems calls for delicate modeling approaches. This book showcases recent contributions in this field, from the development of modeling methodology to its application in supporting the design, development, and optimization of engineering processes.
    Schlagwort(e): pumped hydroelectric storage ; inlet/outlet ; surrogate model selection ; multi-objective optimization process ; thermal environment ; numerical simulations ; ventilation cooling ; duct position ; the heat dissipation of LHD ; auxiliary ventilation ; triboelectric separation ; particle size distribution ; particle charge ; binary mixture ; in situ particle size measurement ; charge estimation ; computational fluid dynamics ; membrane module ; gas separation ; concentration polarization ; coal mining ; radon concentration ; ventilation ; occupational exposure assessment ; gasification ; fluidized bed ; CFD ; hydrodynamics ; multiphase flow ; surface tension modelling ; VOF ; rising bubbles ; capillary rise ; high pressure bubble column ; the critical bubble diameter ; the gas holdup ; the large bubbles ; the small bubbles ; Stirred fermenter ; dual-impeller ; Segment impeller ; Optimization ; rotating packed bed ; natural gas desulfurization ; droplet characteristic ; Eulerian–Lagrangian approach ; heat transport ; optimized design ; dynamic numerical simulation ; evaporative cooling system ; water recycling ; temperature ; humidity ; n/a ; gas–solid ; cyclone separator ; elevated temperature process ; pneumatic conveying ; large coal particles ; Euler–Lagrange approach ; DPM ; pressure drop ; swirling burner ; combustion characteristics ; industrial pulverized coal furnace ; scale-up ; scale-down ; Saccharomyces cerevisiae ; mechanistic kinetic model ; bioreactor ; concentration gradients ; digital twin ; bioprocess engineering ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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  • 85
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-02-02
    Beschreibung: The impairment of neurogenesis may be induced after pre- and post-natal chemical and biological toxin, alcohol, or radiation exposure, drug treatment, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition, and aging. It also occurs as a result of genetic disorders such as Down syndrome (DS), autism, fragile X syndrome (FXS), neurological disorders including Alzheimer's disease (AD), Parkinson's disease (PD) epilepsy, and Huntington's disease (HD), and neuropsychiatric disorders such as depression and schizophrenia; however, the causal relationship between the impairment of neurogenesis and neurological and neuropsychiatric disorders remains unknown. In this Special Issue, entitled “Induced Impairment of Neurogenesis and Brain Diseases”, original animal or cell experimental research and review papers were combined to discuss different causes of the impairment of neurogenesis, relevant neurobehavioral changes, molecular mechanisms, and therapeutic approaches. The aim is to update researchers and clinicians about the complexity of the development of the impairment of neurogenesis, the importance of the involvement of the impairment of neurogenesis in neurological and neuropsychiatric disorders, and to provide some clues for designing novel therapeutic approaches by targeting the impairment of neurogenesis to effectively prevent or treat different genetic, neurological, and neuropsychological disorders.
    Schlagwort(e): neurogenesis ; TGF-β ; smad ; depression ; stress ; complementary and alternative medicines ; natural products ; peripheral nerve injury ; nerve repair ; nerve regeneration ; functional recovery ; neuroinflammation ; microglia ; TSPO ; mitochondria ; cytokines ; antioxidants ; γ-irradiation ; miR-34a-5p ; tia1 ; N6-methyladenosine ; Mettl3 ; Mettl14 ; Fto ; Ythdf1 ; neurodevelopment ; neurodegeneration ; SMG6 ; NMD ; neurodevelopmental syndromes ; ionizing radiation ; aging ; brain ; oxidative stress ; mitochondrial dysfunction ; DNA damage ; gut microbiota ; gut-brain axis ; adult neurogenesis ; ageing ; neural stem cells ; nutrients ; polyphenols ; TRIM32 ; excitatory-inhibitory imbalance ; cortex development ; ASD ; NPCs ; GHSR1 ; ghrelin ; hypoxia ; transcription factors ; progenitor cells ; adult hippocampal neurogenesis ; Alzheimer’s disease ; Aβ peptide ; DNA methylation ; gene expression ; NXN ; CNTNAP1 ; SEPT5-GP1BB ; TBX5 ; miR-146b ; cognition ; anxiety ; astrocytes ; neuronal development ; Gdnf ; microcephaly ; MCPH1 ; central domain ; brain development ; gonad development ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 86
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-04-05
    Beschreibung: In the study of head and neck squamous cell carcinoma (HNSCC), we know that virally induced malignancies behave differently than those generated through other carcinogenic mechanisms. This paradigm extends into differences in tumor growth, treatment response and resistance, as well as invasion and metastasis. The inability to correctly diagnose and appropriately treat HNSCC at early stages has contributed to reduced survival for HNSCC patients, particularly those with HPV-negative disease. The examination of the molecular differences between HPV-positive and HPV-negative HNSCC will provide support for early diagnostic markers and guide appropriate treatment selection to improve patient care and survival.This Special Issue highlights current research efforts to understand the evolving contribution of human papillomavirus in HNSCC.
    Schlagwort(e): head and neck cancer ; human papillomavirus ; oropharyngeal cancer ; virus-related cancers ; human papillomavirus diagnosis ; sinonasal squamous cell carcinoma ; prevalence ; detection method ; anatomic subsite ; photodynamic therapy ; ER/mitochondrial photosensitizer ; paraptosis ; apoptosis ; autophagy ; HPV ; OPSCC ; tonsillar cancer ; survival ; OS ; DFS ; p16 ; recurrence ; cancer subtypes ; gene expression ; oropharynx ; HPV integration ; immune response ; keratinization ; TATI ; Human Papillomavirus (HPV) ; immune status ; hematological parameters ; radiotherapy ; oropharyngeal squamous cell carcinoma ; DNA methylation ; transposable elements ; overall survival ; head and neck squamous cell carcinoma ; extracellular vesicle ; proteomic ; oropharyngeal cancer (OPC) ; human papillomavirus (HPV) ; cancer stem cells (CSCs) ; CSC markers ; prognosis ; tumor heterogeneity ; positron emission tomography ; diffusion-weighted ; dynamic contrast-enhanced ; kinetic modeling ; fast exchange regime model ; community detection algorithm ; spin-glass model ; high-risk human papillomaviruses ; head and neck squamous cell carcinomas ; viral DNA integration ; PCR ; DIPS-PCR ; APOT-PCR ; WGS ; WES ; capture-based assay ; RNASeq ; FISH ; consequences of HPV integration ; p53 ; cancer ; glycolysis ; oxidative phosphorylation ; metabolism ; biomarkers ; staging ; TNM ; prognostic ; T regulatory lymphocytes ; FoxP3 ; Langerhans cells ; CD1a ; immune cells ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 87
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-02-02
    Beschreibung: Dinoflagellates are an important group of aquatic microbial eukaryotes, showing great diversity in life histories, ecological niches, morphology, and pigment composition. They include species with photosynthetic, heterotrophic, symbiotic, mixotrophic, and parasitic lifestyles, and encompass coral symbionts, harmful algal bloom forming species, and important fish parasites. They are present in fossil records that date back several hundred million years. Dinoflagellates include the majority of species that produce marine biotoxins, impacting aquaculture. In recent years, molecular approaches have been applied to understand dinoflagellate biology, including techniques for studying dinoflagellate ecology, physiology, basic genetics, and evolution. This Special Issue, edited by Professor Shauna Murray, is dedicated to the application and development of molecular approaches for enhancing our understanding of dinoflagellate biology.
    Schlagwort(e): nanoplastics ; dinoflagellate ; coral reef ; Symbiodinium ; Cladocopium ; gene expression ; Prorocentrum minimum ; harmful algae ; next-generation sequencing ; cDNA library ; coral reefs ; Hemerythrin-like protein ; RACK1 ; spliced leader ; yeast two-hybrid ; bioluminescence ; Pyrodinium bahamense ; harmful algal blooms ; saxitoxin ; sxtA4 ; RNA-seq ; scleractinian coral ; Symbiodiniaceae ; endosymbiosis ; PKS ; phosphopantetheinyl transferase ; toxin ; BpsA ; indigoidine ; natural product ; knockdown ; morpholino ; translation ; dinoflagellates ; metagenomics ; monitoring ; genome ; Cladocopium goreaui ; phylogenomics ; horizontal gene transfer ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 88
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-04-05
    Beschreibung: MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.
    Schlagwort(e): QH426-470 ; QH301-705.5 ; Q1-390 ; microRNAs ; n/a ; lipoprotein ; myofibroblast ; miR-148a ; C2C12 cell line ; endometrial receptivity ; interstitial lung disease ; exon switch ; atherosclerosis ; colorectal cancer ; let-7 ; miR-125b ; idiopathic pulmonary fibrosis ; biomarker ; recurrent implantation failure ; severe acute respiratory syndrome coronavirus ; miRSNP ; transfer ; miR-106a-5p ; somatostatin analogues ; neuroendocrine tumors ; gene expression ; uremia ; HKII ; miRNAs ; metabolic interactions ; non-Hodgkin lymphoma ; PIK3R1 ; small RNA ; miR-7 ; Hexokinase 2 ; CD34 cryptic splicing ; systemic sclerosis ; small RNA-seq ; myogenic differentiation ; proteomics ; CD34 cell-clusters ; palindromic small RNA ; infertility ; gut microbiota ; ORF miRNA target ; DNA complemented palindrome ; rs17723799 ; complemented palindromic small RNA ; MIR143 ; microRNA ; cancer ; muscle atrophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
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  • 89
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Sustainability, defined as ‘meeting current needs without compromising the future’, is a widely accepted goal across many sectors of society. Sustainability’s criteria and indicators often only regard sustaining present conditions through increased resilience, intended as a system’s capacity to experience shocks while retaining essentially the same functions and structures. However, new sustainability concepts, sometimes referred to as “sustainagility”, also consider the properties and assets of a system that sustains the ability (agility) of agents to adapt and meet their needs in new ways, preparing for future unpredictability and unforeseen changes. Therefore, resilience must coexist with adaptive capacity for real, long-term sustainability. Consumers are paying increasing attention to the sustainability of the food supply chain; thus, sustainable development is necessary for all food processes. Since the olive oil sector has a well-established historical tradition, any change and innovation that aims to obtain a sustainable development not only needs to be analyzed in terms of environmental, economic, and social aspects, it should also be significantly improved and closely monitored. Thus, this Special Issue is a collection of papers that can increase sustainability knowledge in the olive-oil-processing chain, to take a significant step forward in future developments.
    Schlagwort(e): extra virgin olive oil ; authentication ; chemometrics ; proton NMR ; carbon NMR ; machine learning ; artificial neural networks ; PLS-DA ; olive leaf polyphenols ; encapsulation ; functional food ; mayonnaise ; alginate/pectin beads ; phenolic extract ; food enrichment ; olive leaves ; organic ; local ; consumer attitude ; up-cycled ingredients ; by-products ; generational differences ; virgin olive oil ; organic production ; harvesting method ; harvesting time ; volatile compounds ; olive by-product ; reactive oxygen species (ROS) ; olive leaf ; pomace ; olive wastewater ; clones ; minor accessions ; olive oil ; quality ; olive landrace ; ripening ; harvest season ; antioxidants ; minor compounds ; oil quality ; circular economy ; environmental impact ; global warming ; valorization of waste ; phenolic compounds ; acidic hydrolysis ; derivative UV spectroscopy ; green chemistry ; screening methods ; health claim ; antioxidant activity ; olive mill wastewaters ; reactive oxygen species ; vascular cells ; breadsticks ; gluten-free ; olive oil by-products ; oxidation stability ; electronic nose ; accelerated shelf-life tests ; transparent plastic material ; metallized material ; brown-amber glass ; oxidation ; stability ; packaging ; olive oil quality ; life cycle assessment ; biocompounds ; shelf life ; environmental sustainability ; biscuits ; gluten-free breadsticks ; salad dressing ; vegan mayonnaise ; waste recovery ; choice experiment (CE) ; extra virgin olive oil (EVOO) ; willingness to pay (WTP) ; country of origin ; organic food ; consumer preferences ; sustainable food system ; authenticity ; biodiversity ; differential scanning calorimetry ; color ; chlorophyll ; geographical origin ; botanical origin ; principal component analysis ; anaerobic codigestion ; biomethane ; life cycle assessment (LCA) ; life cycle costing (LCC) ; olive mill by-products ; olive composition ; olive cultivars ; olive ripening ; PLS regression model ; portable device ; quality parameters ; sustainability ; Olea europaea ; kaolin ; zeolitite ; foliar treatments ; sustainable agriculture ; crop defense ; autochthonous cultivars ; molecular fingerprinting ; polyphenol content ; gene expression ; fruit developmental stages ; n/a ; olive storage duration ; oil chemical composition ; sensory properties ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-06-21
    Beschreibung: The book collects scientific contributions aiming at describing the common mechanism, across living species, by which innate immunity interacts with nanomaterials with the goal of harnessing such interactions for improving environmental and human safety and exploiting them for modulating immunity in vaccination strategies.
    Schlagwort(e): innate immunity ; infection ; microbiome ; survival ; nanomaterials ; nanoparticles ; copper ; earthworms ; Eisenia fetida ; cosmetic formulation ; cosmetic lifecycle ; hydrophobic compound ; nano-TiO2 ; nano safety ; marine invertebrate ; metabolomics ; avian pathogenic Escherichia coli ; nanovaccine ; outer membrane vesicles ; immune response ; broiler ; earthworm ; coelomocyte ; TiO2 nanoparticles ; reactive oxygen species ; lipid peroxidation ; alkaline comet assay ; phagocytosis ; apoptosis ; gene expression ; hemocytes ; Mytilus ; in vitro ; scanning electron microscopy ; innate memory ; Schistosoma mansoni ; monocytes ; macrophages ; vaccination ; gold nanoparticles ; cerium nanoparticles ; woodlice ; haemocyte ; environmental models ; human cells ; markers ; NPs testing ; immune system ; inflammation ; tolerance ; engineered nanomaterial (ENM) ; nanoparticle (NP) ; gold nanoparticle (AuNP) ; plant ; Arabidopsis thaliana ; plant growth ; stress response ; transcriptomics ; proteomics ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Sprache: Englisch
    Format: application/octet-stream
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  • 91
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-09-11
    Beschreibung: 10th Anniversary of Plants—Recent Advances and Perspectives is a scientific paper collection specially published on the anniversary of Plants. Covering all major areas of plant science, it is a valuable guide through current achievements and future discoveries in this scientific field.
    Schlagwort(e): Secale cereale ; Secale montanum ; Secale strictum ; QTL mapping ; molecular marker ; self-incompatibility ; fertility ; seed set ; abiotic stress ; cell homeostasis ; heterologous host synthetic approach ; terpenophenolics ; brown spot ; ACT ; fungus culture filtrate ; mycotoxin ; fruit development ; fruit gauge ; VPD ; Mangifera indica ; cell division ; cell expansion ; ripening ; pulegone ; isomenthone ; menthone ; thymol ; p-cymene ; chemotypes ; seasonal variation ; enantiomeric distribution ; label-free proteomics ; Panax ginseng ; ginsenosides ; cytochrome p450 ; UDP-glycosyltransferase ; MEP pathway ; MVA pathway ; TCA/acetone ; methanol/chloroform ; endophytes ; foliar pathogens ; pathogenicity ; taxonomy ; Thymus vulgaris ; Crithmum maritimum ; leather artifacts ; essential oils ; anti-bacterial activity ; Euphorbia dendroides L. ; aerial parts ; polyphenols ; antioxidant activity ; anti-inflammatory activity ; toxicity ; calcium oxalate crystals ; colleter ; extrafloral nectaries ; resin gland ; bud protection ; plant-environment interaction ; carbohydrate metabolism ; microarray ; crop ; rice ; productivity ; endosperm ; geometry ; morphology ; seed shape ; Vitaceae ; exDNA ; environmental DNA ; DNA sensing ; self-DNA inhibition ; autotoxicity ; plant response ; DAMP ; PAMP ; EDAP ; climate change ; food security ; Mediterranean countries ; sustainable exploitation ; phytogenetic resources ; candidate gene ; quantitative trait locus ; recombinant inbred line ; soybean drought tolerance ; weighted drought coefficient ; antioxidants ; biostimulants ; biotic stress ; GABA ; metabolism ; phytohormones ; reactive oxygen species ; signaling ; tricarboxylic acid cycle ; bacterial functions ; co-presence networks ; metagenomics ; microbial ecology ; plant domestication ; trace element ; plant nutrient ; salinity ; antioxidant defense system ; glyoxalase system ; biochar ; licorice ; soil enzymes ; nutrients ; root system ; ALS ; BCAA ; low oxygen ; flooding ; AIP1 ; Eucommia ulmoides Oliver ; trait variations ; probability grading ; quantitative traits ; planting models ; leaves ; cytokinin ; TD-K ; thidiazuron ; INCYDE ; CPPU ; isopentenyl transferase ; IPT ; cytokinin oxidase/dehydrogenase ; CKX ; wheat ; barley ; yield ; cucumber ; QTL-seq ; SNP markers ; white immature fruit skin color ; ecological costs ; germination models ; herbicide resistance ; hydrotime ; target-site resistance ; hydrogen peroxide ; sodium hypochlorite ; generalized regression neural network ; genetic algorithm ; scarification ; seed dormancy ; plant tissue culture ; foliar descriptors ; leaf area ; models ; vine leaves ; Olea europaea L. ; olive ; genotype by sequencing (GBS) ; single-nucleotide polymorphism (SNP) ; whole-genome sequencing (WGS) ; reference genome ; plastid markers ; DNA barcoding ; ISSR markers ; Egyptian barley ; agro-morphological traits ; cluster analysis ; genetic variation ; biplot ; drought stress ; drying processes ; mathematical model ; plant hydric stress tolerance ; rate of weight loss ; RWLMod ; water evaporation ; photosynthesis ; elevated CO2 ; Rubisco ; electron transport ; light ; diurnal cycle ; sexual propagation ; cold stratification ; in situ ; ex situ ; plant endemism ; Morocco ; biodiversity ; ex-situ conservation ; protocols ; germplasm ; forest berries ; brushing ; lettuce ; chicory ; phytochemicals ; antioxidant capacity ; Ziziphus lotus ; phenolics ; SH-SY5Y cell line ; chromatography ; Koelreuteria paniculata ; dry ethanol extracts ; GC-MS analysis ; chemical compounds ; antitumor and antimicrobial activities ; medicinal plant ; bioactive compounds ; plant-derived secondary metabolites (PDSM) ; cell suspension culture (CSC) ; bioreactor engineering ; apple ; Golden Delicious ; Top Red ; fruitlet thinners ; light reactions ; electron transport rate ; photoprotective mechanism ; state transitions ; PSII repair cycle ; vegetation structure ; environmental variables ; PC-ORD ; plant community assembly ; Himalaya ; allopolyploidy ; interspecific hybridization ; unreduced gametes ; cytological diploidization ; genomic changes ; root length ; root/shoot ratio ; specific root length ; Saragolle Lucana ; seed coating ; heavy metals ; evolution ; hyperaccumulation ; black chokeberry (Aronia melanocarpa) ; anthocyanin stability ; herbs ; co-pigmentation ; color stability ; functional foods/beverages ; biotechnological tools ; ethnomedicine ; in vitro culture ; genetic improvement ; pollen ; tip growth ; calcium ; calcium dependent protein kinase ; Rho Guanine Dissociation Inhibitor ; ROP GTPase ; RhoGDI displacement factor ; polarity ; guar ; gene expression ; qRT-PCR ; RNA-Seq ; salt stress ; salt tolerance ; stress ; transcriptome ; D-tagatose ; IFP48 ; induced resistance ; sweet immunity ; sugar-enhanced defense ; Plasmopara viticola ; Botrytis cinerea ; Vitis vinifera ; human diet ; edible wild plants ; Plantago coronopus L. ; Rumex acetosa L. ; Cichorium intybus L. ; Artemisia dracunculus L. ; phytochemistry ; anti-inflammatory properties ; stem photosynthesis ; hydraulic recovery ; soaking ; X-ray micro-CT ; bark water uptake ; embolism ; genetic resources ; Solanaceae ; Cucumis ; Lactuca ; diversity ; vegetables ; genebank ; essential oil ; iNOS ; interleukin ; lavenders ; NF-κB ; glycosyltransferases ; ER-Golgi trafficking ; mechanism of protein sorting ; COPI and COPII complexes ; sequences and motifs involved in trafficking ; Arabidopsis ; gene regulation ; protein-protein interaction ; transcription factor ; WRI1 ; TCP20 ; lipases ; lipid metabolism ; plant-environment interactions ; reproductive development ; vegetative development ; Urtica dioica ; soilless systems ; cultivated nettle ; stress factors ; functional properties ; preharvest sprouting ; MKK3 ; maternal and paternal expressed genes ; imprinted genes ; polycomb repressive complex 2 ; mRNA processing bodies ; ribonucleic binding proteins ; monosomes ; ethylene ; elicitors ; fruit ripening ; ACC synthase/oxidase ; GC-MS ; polyamines ; Vigna genus ; introgression ; hybridisation ; phylogeny ; de novo domestication ; feralisation ; novel ecosystems ; complex networks ; tree communities ; Lantana camara ; Prosopis juliflora ; ascorbic acid ; genetic diversity ; molecular markers ; aquaculture pond sediment ; recovery ; Triticum aestivum ; chlorophyll fluorescence ; wheat grass juice quality ; UV-B radiation ; olive tree ; metabolomic ; phenolic profile ; lipophilic profile ; ecophysiology ; environment ; arbuscular mycorrhizal symbiosis ; comparative transcriptomics ; Arum-type ; Paris-type ; Solanum lycopersicum ; Rhizophagus irregularis ; Gigaspora margarita ; Camelina sativa ; semi-arid lands ; biofuel feedstock ; biodiesel ; renewable diesel ; crop breeding ; transgenesis ; genome editing ; Xanthomonas euvesicatoria ; host associate factor ; comparative genomics ; Cannabis sativa L. ; chemovars ; secondary metabolites ; trichomes ; residual by-products ; biogeography ; cardioid ; islands ; geometric models ; Mediterranean flora ; Silene ; super-ellipse ; abscisic acid ; aromatic herb ; ascorbate-glutathione cycle ; jasmonic acid ; lipoic acid ; oxidative stress ; salicylic acid ; Salvia officinalis ; drought ; state of stress ; tolerance ; avoidance ; stress survival ; amino acids ; nitrate reductase ; glutamine synthetase ; plants mycorrhized ; dark septate ; Daphne genkwa ; Thymelaeaceae ; flavonoids ; design of experiments ; blooming stages ; germination stimulant ; witchweed ; methyl phenlactonoates (MPs) ; Nijmegen-1 ; weed ; plant development ; vasculature ; leaf traces ; structure ; microtomography ; Euphorbiaceae ; in vitro crop ; gamma radiation ; ionizing radiation ; mutants ; Fumaria scheleicheri Soy. Will. ; isoquinoline alkaloids ; HPLC-DAD ; in vitro anti-cholinesterase ; cytotoxic ; antioxidant ; ABC model ; hop ; transcription factors ; type-II MADS box ; type-I MADS-box ; AFLP ; carpological traits ; genetic structure ; molecular systematics ; plastid phylogeny ; Valerianaceae ; auxins ; embryogenic calli ; HPLC ; IAA ; immunohistochemistry ; deficit irrigation ; grape quality ; phenology ; plant diseases ; bacterium ; symptoms ; molecular classification ; common juniper ; common larch ; Cupressaceae ; Pinaceae ; SPME-GC-MS ; volatile compounds ; herbicidal activity ; weed control ; trait association ; GCV ; genetic variability ; genetic advance ; heritability ; PCV ; Cicer arietinum L. ; gold nanoparticles ; carbon nanotubes ; ATR-FTIR spectroscopy ; machine learning techniques ; principal component analysis ; support vector machine classification ; citrus ; melanose ; Diaporthe citri ; epidemiology ; symptomatology ; Pseudomonas cannabina pv. alisalensis ; resistance-nodulation-cell division transporter ; type-three secretion system ; phytoalexin ; brassinin ; glucosinolate ; cabbage ; flowering ; juvenile traits ; genetic stability ; flow cytometry ; somaclonal variation ; thorniness ; carbohydrates ; protein ; lipids ; fatty acids ; minerals ; plastome ; Plicosepalus acaciae ; Plicosepalus curviflorus ; loranthaceae ; mistletoe ; phylogenetic relationship ; plastome structure ; comparative analysis ; magnetic resonance imaging ; Solanum tuberosum ; multi-exponential transverse relaxation ; water stress ; broccoli ; human nutrition ; improved health ; melatonin ; postharvest ; apricot ; pollen tube ; pollination ; Prunus armeniaca ; S-alleles ; Populus ; hexokinase ; sucrose metabolism ; sugar signaling ; stress and defense ; centres of origin ; crop wild relatives ; crop domestication ; cryopreservation ; conservation ; in vitro storage ; ecosystem restoration ; plant breeding ; acidification ; alkalinisation ; bud burst ; freezing ; Malus domestica ; pH ; Picea abies ; Pinus cembra ; histone modification ; Taraxacum kok-saghyz ; natural rubber ; high light stress ; singlet oxygen ; signalling ; GPX5 ; beta cyclocitral ; acrolein ; glutathione peroxidase ; carbonyl ; transcription ; SLIM1 transcription factor ; sulfur deficiency ; Arabidopsis thaliana ; sulfate transporter ; sulfate assimilation ; stress tolerance ; LRR-RLK receptors ; dodders ; parasitic plants ; proteomics ; virus vertical transmission ; CMV-Fny strain ; pseudorecombinant virus ; chimeric virus ; infection rate ; seed-growth tests ; electron microscopy ; circular dichroism spectroscopy ; viral assembly ; Adiantetea capilli-veneris ; demographic analysis ; ecology ; IUCN ; plant conservation ; phytosociology ; rupicolous habitat ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-03-07
    Beschreibung: The eradication of vector-borne diseases is threatened by the limited range of available insecticides, leading, inevitably, to the development of resistance. This is particularly concerning for malaria control, which relies heavily on insecticide-treated nets (ITNs) and indoor residual sprays (IRS). New chemistries are being developed, and innovative deployment of insecticides may play a role in overcoming resistance, either through new types of tools or new means of distribution. A variety of novel product types and vector control strategies are under development and evaluation, which is to be celebrated, but a strong evidence base is needed to guide effective operational deployment decisions. Novel approaches should be supported by robust data collected using appropriate and validated methods to monitor efficacy, durability, and any emerging resistance. This reprint presents original research into developing and characterizing new vector control products, as well as understanding and monitoring insecticide resistance. Review articles explore the impact of insecticide resistance and offer guidance on insecticide choice in the face of pyrethroid resistance. Consensus methodologies are presented, in the form of standard operating procedures (SOPs) designed to be adopted and used to generate reproducible data that can be compared and interpreted across and between studies. It is hoped that this collection of articles offers inspiration and guidance on how consistent data can be generated to inform more effective development, evaluation, and use of new and existing vector control tools.
    Schlagwort(e): prallethrin ; insecticide ; spatial treatment ; mosquito fitness ; protection ; pyrethroids ; Aedes albopictus ; Culex pipiens ; life tables ; mosquito ; bite-proof garment ; model ; textile ; non-insecticidal ; physical barrier ; insecticide selection ; out-crossing ; strain authentication ; laboratory screening ; pyrethroid ; pyrethroid resistance ; insecticide resistance ; insecticide resistance management ; vector control ; malaria ; malaria control ; Anopheles ; host-seeking behavior ; insecticide exposure ; pathogen transmission ; Aedes aegypti ; Anopheles gambiae ; ATSB ; Culex quinquefasciatus ; Iroquois ; RNAi ; Saccharomyces cerevisiae ; yeast ; Anopheles mosquito ; fertility ; ovary development ; pyriproxyfen (PPF) ; side-effects ; machine learning ; image classification ; automated identification ; convolutional neural network ; insecticide-treated net (ITN) ; PBO ITN ; synergist ITN ; dual-AI ITN ; insecticide resistance management (IRM) ; method validation ; durability monitoring ; bioinsecticide ; disease transmission ; insecticide-resistance ; mosquito-borne disease ; mosquito control ; natural compounds ; phytochemical ; malaria vector ; insecticide treated nets ; cytochrome P450s ; kdr ; cuticular resistance ; deltamethrin ; imidacloprid ; bifenthrin ; β-cyfluthrin ; etofenprox ; α-cypermethrin ; λ-cyhalothrin ; thiacloprid ; mosquitoes ; Attractive Toxic Sugar Bait (ATSB) ; Attractive Targeted Sugar Bait (ATSB) ; diagnostic bioassay ; resistance monitoring ; insecticide-treated nets (ITN) ; strain characterisation ; method development ; product evaluation ; quality control (QC) ; dual active ingredients (dual-AI) ; bioefficacy ; IRS ; application technology ; broflanilide ; clothianidin ; pirimiphos-methyl ; WHO tube ; WHO tunnel test ; ITNs ; interceptor ; interceptor G2 ; membrane ; human arm ; rabbit ; bioassay ; bio-efficacy ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science
    Sprache: Englisch
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  • 93
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-05-11
    Beschreibung: Toxins are biologically active substances produced by most kinds of living organisms, bacteria, fungi, plants, and animals. They present a vast diversity of molecular structures and target a wide variety of receptors involved in a range of physiological processes. As toxins are selected during evolution to acquire/improve their disabling/lethal effects, they display finely tuned functional properties often associated with high affinities and selectivity. Moreover, toxins are valuable tools to unravel cellular processes due to their extreme specificity for cell surface and/or intracellular targets. Therefore, toxins are very attractive compounds because of their Janus-like character; while they mostly act as deadly poisons like monstrous Mr. Hyde, they can also be tamed into good remedies like admirable Dr. Jekyll. As such, they have been primarily investigated not only for the light they can throw on fundamental physiological processes but also for their potential therapeutic applications. This reprint, emerging from the 27th Annual Meeting of the French Society of Toxinology (SFET, http://sfet.asso.fr/international), will be of great interest for those in the scientific community who want to know more about the fascinating world of toxins.
    Schlagwort(e): toxins ; peptide chemistry ; native chemical ligation ; α-bungarotoxin ; click chemistry ; automated patch-clamp ; fluorescent peptide ; TE671 cells ; nicotinic acetylcholine receptor ; animal toxin ; bacterial toxin ; marine toxin ; medical application ; plant toxin ; toxin function/activity ; toxin receptor/target ; toxin structure ; Debaryomyces hansenii ; Wickerhamomyces anomalus ; Saccharomyces cerevisiae ; PDR transporters ; killer toxin ; fetal adrenomedullary chromaffin cell ; gambierol ; potassium currents ; calcium-activated K+ channels ; ATP-sensitive K+ channels ; catecholamine release ; Clostridium tetani ; Clostridium botulinum ; botulinum neurotoxin ; tetanus neurotoxin ; toxin gene regulation ; two-component system ; small RNA ; adenylate cyclase toxin ; Bordetella pertussis ; cyclic nucleotide ; cAMP ; spectrophotometric enzymatic assay ; ASIC ; sodium channels ; peptide ; PcTx1 ; APETx2 ; MitTx ; mambalgin ; pain ; nociception ; clostridial C3 toxin ; C3bot ; C3botE174Q ; dendritic cells ; macrophages ; monocytes ; stimulated emission depletion (STED) ; super-resolution microscopy ; trained immunity ; effector-triggered immunity ; effector-triggered trained immunity ; staphylococcal superantigen ; enterotoxin ; toxin pathogenicity ; immunomodulation ; molecular and cellular targets ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 94
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: In this Special Issue, authors from nine countries on five continents provide overviews on and insights into current research topics related to the ‘Genetic Complexity of Hormone-Sensitive Cancers’. The chapters cover topics on completely novel technologies and instruments revolutionizing our view of biological entities, and also, novel extensions and revisions of existing and well-established technologies such as genetic probes and bar-coding techniques, which add a new dimension to microscopy, as they allow us to visualize DNA sequences and mRNA in situ. With this Special Issue, the editors wanted to create a forum for the international biomedical research community to compile their data on the genetic complexity of cancer in a unique resource. While this collection of articles cannot certainly claim completeness in any way, it represents an attractive collection of the different aspects of hormone-dependent cancers and will hopefully encourage further targeted research.
    Schlagwort(e): palbociclib ; estrogen receptor ; breast cancer ; CDK4/6 ; CDK4/6 inhibitors ; therapy resistance ; DNA repair ; metabolic rewiring ; quantitative proteomics ; urothelial carcinoma ; molecular subtypes ; therapeutic target ; prostate cancer ; prognostic signature ; diagnostic signature ; biomarkers ; cancer progression ; aggressive cancer ; androgen receptor ; gene expression ; insulin receptor ; germline mutations ; somatic mutations ; PTEN ; TMPRSS2 ; ERG ; androgen receptors ; cervical cancer ; alternative splicing ; SR proteins ; hnRNP ; drug resistance ; head and neck squamous cell carcinoma (HNSCC) ; aberrant splicing events ; human papillomavirus (HPV) infection ; non-coding RNA (ncRNA) ; methylation ; mutational burden ; next-generation digital histopathology ; tissue cytometry ; multiplexing ; RNA ISH ; cancer ; tumor immune microenvironment ; tumor microenvironment ; IRX4 ; transcript ; isoforms ; long non-coding RNA ; single nucleotide polymorphisms ; genome-wide association studies ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 95
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-09-11
    Beschreibung: 10th Anniversary of Plants—Recent Advances and Perspectives is a scientific paper collection specially published on the anniversary of Plants. Covering all major areas of plant science, it is a valuable guide through current achievements and future discoveries in this scientific field.
    Schlagwort(e): Secale cereale ; Secale montanum ; Secale strictum ; QTL mapping ; molecular marker ; self-incompatibility ; fertility ; seed set ; abiotic stress ; cell homeostasis ; heterologous host synthetic approach ; terpenophenolics ; brown spot ; ACT ; fungus culture filtrate ; mycotoxin ; fruit development ; fruit gauge ; VPD ; Mangifera indica ; cell division ; cell expansion ; ripening ; pulegone ; isomenthone ; menthone ; thymol ; p-cymene ; chemotypes ; seasonal variation ; enantiomeric distribution ; label-free proteomics ; Panax ginseng ; ginsenosides ; cytochrome p450 ; UDP-glycosyltransferase ; MEP pathway ; MVA pathway ; TCA/acetone ; methanol/chloroform ; endophytes ; foliar pathogens ; pathogenicity ; taxonomy ; Thymus vulgaris ; Crithmum maritimum ; leather artifacts ; essential oils ; anti-bacterial activity ; Euphorbia dendroides L. ; aerial parts ; polyphenols ; antioxidant activity ; anti-inflammatory activity ; toxicity ; calcium oxalate crystals ; colleter ; extrafloral nectaries ; resin gland ; bud protection ; plant-environment interaction ; carbohydrate metabolism ; microarray ; crop ; rice ; productivity ; endosperm ; geometry ; morphology ; seed shape ; Vitaceae ; exDNA ; environmental DNA ; DNA sensing ; self-DNA inhibition ; autotoxicity ; plant response ; DAMP ; PAMP ; EDAP ; climate change ; food security ; Mediterranean countries ; sustainable exploitation ; phytogenetic resources ; candidate gene ; quantitative trait locus ; recombinant inbred line ; soybean drought tolerance ; weighted drought coefficient ; antioxidants ; biostimulants ; biotic stress ; GABA ; metabolism ; phytohormones ; reactive oxygen species ; signaling ; tricarboxylic acid cycle ; bacterial functions ; co-presence networks ; metagenomics ; microbial ecology ; plant domestication ; trace element ; plant nutrient ; salinity ; antioxidant defense system ; glyoxalase system ; biochar ; licorice ; soil enzymes ; nutrients ; root system ; ALS ; BCAA ; low oxygen ; flooding ; AIP1 ; Eucommia ulmoides Oliver ; trait variations ; probability grading ; quantitative traits ; planting models ; leaves ; cytokinin ; TD-K ; thidiazuron ; INCYDE ; CPPU ; isopentenyl transferase ; IPT ; cytokinin oxidase/dehydrogenase ; CKX ; wheat ; barley ; yield ; cucumber ; QTL-seq ; SNP markers ; white immature fruit skin color ; ecological costs ; germination models ; herbicide resistance ; hydrotime ; target-site resistance ; hydrogen peroxide ; sodium hypochlorite ; generalized regression neural network ; genetic algorithm ; scarification ; seed dormancy ; plant tissue culture ; foliar descriptors ; leaf area ; models ; vine leaves ; Olea europaea L. ; olive ; genotype by sequencing (GBS) ; single-nucleotide polymorphism (SNP) ; whole-genome sequencing (WGS) ; reference genome ; plastid markers ; DNA barcoding ; ISSR markers ; Egyptian barley ; agro-morphological traits ; cluster analysis ; genetic variation ; biplot ; drought stress ; drying processes ; mathematical model ; plant hydric stress tolerance ; rate of weight loss ; RWLMod ; water evaporation ; photosynthesis ; elevated CO2 ; Rubisco ; electron transport ; light ; diurnal cycle ; sexual propagation ; cold stratification ; in situ ; ex situ ; plant endemism ; Morocco ; biodiversity ; ex-situ conservation ; protocols ; germplasm ; forest berries ; brushing ; lettuce ; chicory ; phytochemicals ; antioxidant capacity ; Ziziphus lotus ; phenolics ; SH-SY5Y cell line ; chromatography ; Koelreuteria paniculata ; dry ethanol extracts ; GC-MS analysis ; chemical compounds ; antitumor and antimicrobial activities ; medicinal plant ; bioactive compounds ; plant-derived secondary metabolites (PDSM) ; cell suspension culture (CSC) ; bioreactor engineering ; apple ; Golden Delicious ; Top Red ; fruitlet thinners ; light reactions ; electron transport rate ; photoprotective mechanism ; state transitions ; PSII repair cycle ; vegetation structure ; environmental variables ; PC-ORD ; plant community assembly ; Himalaya ; allopolyploidy ; interspecific hybridization ; unreduced gametes ; cytological diploidization ; genomic changes ; root length ; root/shoot ratio ; specific root length ; Saragolle Lucana ; seed coating ; heavy metals ; evolution ; hyperaccumulation ; black chokeberry (Aronia melanocarpa) ; anthocyanin stability ; herbs ; co-pigmentation ; color stability ; functional foods/beverages ; biotechnological tools ; ethnomedicine ; in vitro culture ; genetic improvement ; pollen ; tip growth ; calcium ; calcium dependent protein kinase ; Rho Guanine Dissociation Inhibitor ; ROP GTPase ; RhoGDI displacement factor ; polarity ; guar ; gene expression ; qRT-PCR ; RNA-Seq ; salt stress ; salt tolerance ; stress ; transcriptome ; D-tagatose ; IFP48 ; induced resistance ; sweet immunity ; sugar-enhanced defense ; Plasmopara viticola ; Botrytis cinerea ; Vitis vinifera ; human diet ; edible wild plants ; Plantago coronopus L. ; Rumex acetosa L. ; Cichorium intybus L. ; Artemisia dracunculus L. ; phytochemistry ; anti-inflammatory properties ; stem photosynthesis ; hydraulic recovery ; soaking ; X-ray micro-CT ; bark water uptake ; embolism ; genetic resources ; Solanaceae ; Cucumis ; Lactuca ; diversity ; vegetables ; genebank ; essential oil ; iNOS ; interleukin ; lavenders ; NF-κB ; glycosyltransferases ; ER-Golgi trafficking ; mechanism of protein sorting ; COPI and COPII complexes ; sequences and motifs involved in trafficking ; Arabidopsis ; gene regulation ; protein-protein interaction ; transcription factor ; WRI1 ; TCP20 ; lipases ; lipid metabolism ; plant-environment interactions ; reproductive development ; vegetative development ; Urtica dioica ; soilless systems ; cultivated nettle ; stress factors ; functional properties ; preharvest sprouting ; MKK3 ; maternal and paternal expressed genes ; imprinted genes ; polycomb repressive complex 2 ; mRNA processing bodies ; ribonucleic binding proteins ; monosomes ; ethylene ; elicitors ; fruit ripening ; ACC synthase/oxidase ; GC-MS ; polyamines ; Vigna genus ; introgression ; hybridisation ; phylogeny ; de novo domestication ; feralisation ; novel ecosystems ; complex networks ; tree communities ; Lantana camara ; Prosopis juliflora ; ascorbic acid ; genetic diversity ; molecular markers ; aquaculture pond sediment ; recovery ; Triticum aestivum ; chlorophyll fluorescence ; wheat grass juice quality ; UV-B radiation ; olive tree ; metabolomic ; phenolic profile ; lipophilic profile ; ecophysiology ; environment ; arbuscular mycorrhizal symbiosis ; comparative transcriptomics ; Arum-type ; Paris-type ; Solanum lycopersicum ; Rhizophagus irregularis ; Gigaspora margarita ; Camelina sativa ; semi-arid lands ; biofuel feedstock ; biodiesel ; renewable diesel ; crop breeding ; transgenesis ; genome editing ; Xanthomonas euvesicatoria ; host associate factor ; comparative genomics ; Cannabis sativa L. ; chemovars ; secondary metabolites ; trichomes ; residual by-products ; biogeography ; cardioid ; islands ; geometric models ; Mediterranean flora ; Silene ; super-ellipse ; abscisic acid ; aromatic herb ; ascorbate-glutathione cycle ; jasmonic acid ; lipoic acid ; oxidative stress ; salicylic acid ; Salvia officinalis ; drought ; state of stress ; tolerance ; avoidance ; stress survival ; amino acids ; nitrate reductase ; glutamine synthetase ; plants mycorrhized ; dark septate ; Daphne genkwa ; Thymelaeaceae ; flavonoids ; design of experiments ; blooming stages ; germination stimulant ; witchweed ; methyl phenlactonoates (MPs) ; Nijmegen-1 ; weed ; plant development ; vasculature ; leaf traces ; structure ; microtomography ; Euphorbiaceae ; in vitro crop ; gamma radiation ; ionizing radiation ; mutants ; Fumaria scheleicheri Soy. Will. ; isoquinoline alkaloids ; HPLC-DAD ; in vitro anti-cholinesterase ; cytotoxic ; antioxidant ; ABC model ; hop ; transcription factors ; type-II MADS box ; type-I MADS-box ; AFLP ; carpological traits ; genetic structure ; molecular systematics ; plastid phylogeny ; Valerianaceae ; auxins ; embryogenic calli ; HPLC ; IAA ; immunohistochemistry ; deficit irrigation ; grape quality ; phenology ; plant diseases ; bacterium ; symptoms ; molecular classification ; common juniper ; common larch ; Cupressaceae ; Pinaceae ; SPME-GC-MS ; volatile compounds ; herbicidal activity ; weed control ; trait association ; GCV ; genetic variability ; genetic advance ; heritability ; PCV ; Cicer arietinum L. ; gold nanoparticles ; carbon nanotubes ; ATR-FTIR spectroscopy ; machine learning techniques ; principal component analysis ; support vector machine classification ; citrus ; melanose ; Diaporthe citri ; epidemiology ; symptomatology ; Pseudomonas cannabina pv. alisalensis ; resistance-nodulation-cell division transporter ; type-three secretion system ; phytoalexin ; brassinin ; glucosinolate ; cabbage ; flowering ; juvenile traits ; genetic stability ; flow cytometry ; somaclonal variation ; thorniness ; carbohydrates ; protein ; lipids ; fatty acids ; minerals ; plastome ; Plicosepalus acaciae ; Plicosepalus curviflorus ; loranthaceae ; mistletoe ; phylogenetic relationship ; plastome structure ; comparative analysis ; magnetic resonance imaging ; Solanum tuberosum ; multi-exponential transverse relaxation ; water stress ; broccoli ; human nutrition ; improved health ; melatonin ; postharvest ; apricot ; pollen tube ; pollination ; Prunus armeniaca ; S-alleles ; Populus ; hexokinase ; sucrose metabolism ; sugar signaling ; stress and defense ; centres of origin ; crop wild relatives ; crop domestication ; cryopreservation ; conservation ; in vitro storage ; ecosystem restoration ; plant breeding ; acidification ; alkalinisation ; bud burst ; freezing ; Malus domestica ; pH ; Picea abies ; Pinus cembra ; histone modification ; Taraxacum kok-saghyz ; natural rubber ; high light stress ; singlet oxygen ; signalling ; GPX5 ; beta cyclocitral ; acrolein ; glutathione peroxidase ; carbonyl ; transcription ; SLIM1 transcription factor ; sulfur deficiency ; Arabidopsis thaliana ; sulfate transporter ; sulfate assimilation ; stress tolerance ; LRR-RLK receptors ; dodders ; parasitic plants ; proteomics ; virus vertical transmission ; CMV-Fny strain ; pseudorecombinant virus ; chimeric virus ; infection rate ; seed-growth tests ; electron microscopy ; circular dichroism spectroscopy ; viral assembly ; Adiantetea capilli-veneris ; demographic analysis ; ecology ; IUCN ; plant conservation ; phytosociology ; rupicolous habitat ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Sprache: Englisch
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  • 96
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-04-05
    Beschreibung: Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease. This reprint contains original and review articles by experts at the cutting edge of their fields published in a Special Issue on the “Molecular mechanisms of steroid hormone biosynthesis and action” of the International Journal of Molecular Sciences. The topics include: 1) Steroid hormone biosynthesis, including substrate availability, mechanism of steroidogenic enzyme action, and the impact of mutations; 2) Molecular and cellular regulation of steroidogenesis, including steroidogenic cell response to hormone stimulation, signaling pathways, kinases, transcription factors, and gene expression; 3) Molecular mechanisms of endocrine disruptor action on steroidogenic cells; and 4) New tools and approaches to detect and study steroid hormones.
    Schlagwort(e): steroidogenesis ; testis ; transcription ; testosterone ; Leydig cell ; GATA ; cholesterol ; cholesterol transport ; steroidogenic acute regulatory protein ; sterol carrier protein 2 ; sterol carrier protein-x ; MnHR4 ; 20-hydroxyecdysone (20E) ; Macrobrachium nipponense ; molt ; RNA interference ; Leydig cells ; star ; AMPK ; phosphoproteomics ; proteomics ; activator protein 1 ; CREB ; CEBPB ; Steroidogenesis ; signaling cascade ; Nuclear receptors ; bZIP factors ; MEF2 factors ; GATA4 ; CAMKI ; PKA ; ERK1/2 ; Hippo signaling ; Lats1/2 ; fetal Leydig cells ; Sertoli cells ; transgenic mouse model ; ovary ; cow ; Hippo ; follicle deviation or divergence ; yes-associated protein 1 ; CTGF ; CYR61 ; ANKRD1 ; transgenic mice ; adrenal cortex ; development ; maintenance ; glucocorticoid receptor ; androgens ; leydig cells ; AAV9 ; insulin-like 3 ; transcription factors ; linker-scanning mutagenesis ; DNA–protein interactions ; bile acids ; TGR5 ; cholesterol esters ; LH ; LH-receptor ; spermatogenesis ; thrombospondin-2 ; NR5A1 ; enhancer ; pituitary gonadotrope ; luteinizing hormone ; follicle-stimulating hormone ; 11-oxygenated androgens ; steroid hormones ; LC-MS/MS ; method validation ; adrenocortical carcinoma ; histone deacetylase inhibitor ; cell differentiation ; gene expression ; adrenal gland inner cortex ; X-zone ; DHCR24 ; seladin-1 ; endocrine disruptors ; EDC mixtures ; in utero exposures ; transcriptome analysis ; testicular function ; aldo-keto reductase ; bile acid ; deficiency ; congenital adrenal hyperplasia ; hydroxysteroid dehydrogenase ; prostate cancer ; single nucleotide polymorphism ; structure-function ; steroid reductase ; pseudohermaphroditism ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
    Format: application/octet-stream
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-12-21
    Beschreibung: Treatment strategies for breast cancer are wide-ranging and often based on a multi-modality approach, depending on the stage and biology of the tumour and the acceptance and tolerance of the patient. They may include surgery, radiotherapy, and systemic therapy (endocrine therapy, chemotherapy, and targeted therapy). Advances in technologies such as oncoplastic surgery, radiation planning and delivery, and genomics, and the development of novel systemic therapy agents alongside their evaluation in ongoing clinical trials continue to strive for improvements in outcomes. In this Special Issue, we publish a collection of studies looking at all forms of therapeutic strategies for early and advanced breast cancer, focusing on their outcomes, notably survival.
    Schlagwort(e): R5-920 ; RC31-1245 ; relative survival ; young women ; cancer treatment ; n/a ; fulvestrant ; lapatinib ; tumor biology ; antihormone therapy ; mastectomy ; aromatase inhibitors ; chemotherapy ; serum biomarker ; cyclin E ; anthracycline resistance ; zero-inflated Poisson regression model ; lymph-node ratio ; CHEK2 ; comparative effectiveness ; breast-conserving therapy ; taxane sensitivity ; liquid biopsy ; HER2 c-erbB2 ; colorectal cancer ; infiltrating breast cancer ; survival ; exercise characteristics ; lactate dehydrogenase ; biomarker ; breast cancer survivors ; BRCA ; disease-free survival ; PIK3CA ; metastatic breast cancer ; cell-free DNA ; invasive breast cancer ; radiotherapy ; Metformin ; social well-being ; gene expression ; contralateral breast cancer ; basal-like breast cancer ; LMK-235 ; Src kinase ; HER2/neu ; LKB1 ; Older women ; LDH ; mutation carriers ; stage IV ; mammography screening ; NCDB ; cMet ; SEER ; pertuzumab ; physical function ; outcome ; ribociclib ; older patients ; geriatric oncology ; metastatic ; overdiagnosis ; next-generation sequencing ; abemaciclib ; Endocrine therapy ; monitoring metastatic breast cancer ; breast cancer ; circulating tumor cells ; Breast Cancer ; PALB2 ; histone deacetylase ; prognosis ; physical activity ; trastuzumab ; ductal carcinoma in situ ; contralateral prophylactic mastectomy ; ERCC1 ; family history ; T-DM1 ; ATM ; advanced breast cancer ; incidence ; palbociclib ; HDAC5 inhibitors ; APOBEC3B ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
    Format: application/octet-stream
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-06-23
    Beschreibung: Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of the blood–optic nerve barrier, and, eventually, the induction of apoptosis of retinal ganglion cells (RGCs), resulting in optic atrophy. To date, there is no effective treatment for most optic neuropathies; however, because the damage initially is axogenic, there may exist a window of therapeutic opportunity before the death of RGCs. Thus, the search for effective treatments for various optic neuropathies before there is permanent damage to prevent or limit visual dysfunction and the development of methods to stimulate axon and/or RGC regeneration to restore vision after damage has occurred is pivotal.This reprint collected 19 articles published in this Special Issue of IJMS which covers the molecular mechanisms to protect RGCs and/or axonal damage, translational research, gene therapy, regenerative medicine, and neuroprotection for glaucoma.
    Schlagwort(e): neuroprotection ; retinal ganglion cells ; optic neuropathy ; glaucoma ; pattern electroretinogram ; NMO ; astrocytes ; apoptosis ; BID ; inflammation ; neuroimmunology ; erythropoietin ; retinal ganglion cell ; optic nerve protection ; neuromyelitis optica spectrum disease ; aquaporin-4 ; myelin oligodendrocyte glycoprotein ; ocular coherence tomography ; complement ; microcystic macular degeneration ; Müller cell ; astrocyte ; oligodendrocyte ; microglia ; optic nerve head ; lamina cribrosa ; lamina cribrosa cells ; scleral fibroblasts ; glial cells ; intraocular pressure ; rat anterior ischemic optic neuropathy model ; retinal ganglion cell death ; TBP associated factor 9 ; TP53 regulated inhibitor of apoptosis 1 ; transcriptome ; optic nerve ; epigenetics ; myelin ; regeneration ; oligodendrocytes ; atypical optic neuritis treatment ; typical optic neuritis ; MOG ; MS prevention ; retina ; transcription ; CNS repair ; oncomodulin ; myeloid cells ; glaucomatous optic neuropathy ; fibrosis ; miR-29 ; extracellular matrix ; optic nerve crush ; azithromycin ; NAION ; neural injury ; neural ischemia ; neural inflammation ; Leber’s hereditary optic neuropathy ; LHON ; whole exome sequencing ; nuclear modifier genes ; leber’s hereditary optic neuropathy ; mitochondrial disorder ; mitochondrial optic neuropathy ; hereditary optic neuropathy ; neuro-ophthalmology ; idebenone ; nonarteritic anterior ischemic optic neuropathy ; rodents ; gene expression ; models ; diabetes ; ischemic optic neuropathy ; pioglitazone ; HSF1 ; Klf4 ; Oct4 ; Sox2 ; Yamanaka factors ; optic nerve regeneration ; zebrafish ; oligodendrocyte precursor cells ; secondary degeneration ; oxidative stress ; DNA damage ; proliferation ; blood-brain barrier ; CNS injury ; optic nerve injury ; synaptamide ; A8 ; axonal degeneration ; neuronal survival ; visual evoked potential ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2023-06-23
    Beschreibung: This reprint, edited by Prof. Gaetano Santulli, MD, PhD, collects the most up-to-date peer-reviewed scientific papers dealing with cardiovascular medicine, from basic science to pre-clinical and clinical investigations, highlighting the fundamental importance of translational medicine in the challenging quest for new therapies to cure cardiovascular disease. Indeed, cardiovascular disease is the leading cause of death worldwide, and the search for novel mechanisms and therapeutics is desperately needed. Therefore, both basic and translational studies in the cardiovascular field represent a paramount strategy to identify novel therapeutic targets and improve the quality of life of patients with cardiovascular disorders.
    Schlagwort(e): cardiovascular disease ; vaccine ; clinical trials ; translational medicine ; atherosclerosis ; oxLDL ; phosphorylcholine ; RBP-4 ; insulin resistance ; severity of CAD ; T2D ; atherosclerotic CAD ; endothelial dysfunction ; hypoxia ; HIF-1α ; mitochondria ; oxidative stress ; inflammation ; cardiovascular diseases ; cancer ; therapeutic target ; extracellular NAD+ metabolism ; extracellular NMN metabolism ; vascular endothelial cells ; CD38 ; CD73 ; myocardial infarction ; neuregulin ; glial growth factor 2 ; pre-clinical therapy ; skeletal muscle ; gene expression ; RNA sequencing ; inflammatory bowel disease ; limb ischemia ; endothelial function ; ROS ; acute myocardial infarction ; diabetes ; lactic acid ; carbonic anhydrase ; CD34 ; endothelial cells ; ERG ; hypothermic oxygenated perfusion ; liver transplantation ; machine perfusion ; nestin ; VEGFR ; IDH1 ; foam cell ; macrophage ; ferroptosis ; NRF2 ; atrial fibrillation ; obesity ; immune infiltration ; biomarkers ; cardiac fibrosis ; lncRNAs ; TGF-β ; ECMs ; exosome ; red blood cells ; chemotherapy ; anemia ; microcirculation ; laser diffraction ; osmotic fragility test ; microfluidics ; valvular heart disease ; degenerative aortic valve stenosis ; irisin ; periostin ; osteoglycin ; IL-18 ; HMGB-1 ; PCSK9 ; blood–brain barrier ; blood pressure ; cerebrovascular disease ; hBMECs ; hypertension ; HUVEC ; microRNA ; miRNA ; miR-4432-3p ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-01-31
    Beschreibung: The plant hormone jasmonic acid (JA) and its derivative, an amino acid conjugate of JA (jasmonoyl isoleucine, JA-Ile), are signaling compounds involved in the regulation of defense and development in plants. The number of articles studying on JA has dramatically increased since the 1990s. JA is recognized as a stress hormone that regulates the plant response to biotic stresses such as herbivore and pathogen attacks, as well as abiotic stresses such as wounding and ultraviolet radiation. Recent studies have remarkably progressed the understanding of the importance of JA in the life cycle of plants. JA is directly involved in many physiological processes, including stamen growth, senescence, and root growth. JA regulates production of various metabolites such as phytoalexins and terpenoids. Many regulatory proteins involved in JA signaling have been identified by screening for Arabidopsis mutants. However, much more remains to be learned about JA signaling in other plant species. This Special Issue, “Jasmonic Acid Pathway in Plants”, contains 5 review and 15 research articles published by field experts. These articles will help with understanding the crucial roles of JA in its response to the several environmental stresses and development in plants.
    Schlagwort(e): SB1-1110 ; QH301-705.5 ; Q1-390 ; transcription factor ; n/a ; ectopic metaxylem ; elicitor ; methyl jasmonate ; salicylic acid ; multiseeded ; Panax ginseng ; tea ; heterotrimeric G proteins ; Chinese flowering cabbage ; biosynthesis ; endocytosis ; jasmonic acid signaling ; MutMap ; JA-Ile ; gibberellic acid ; nitric oxide ; abiotic stresses ; MAP kinase ; light-sensitive ; transcriptional activation ; TIFY ; JAZ repressors ; JA ; gene expression ; environmental response ; xylogenesis ; priming ; jasmonate ; circadian clock ; phylogenetic analysis ; chloroplast ; Pogostemon cablin ; albino ; antioxidant enzyme activity ; stress ; Jas domain ; Zea mays ; auxin ; PatJAZ6 ; rice bacterial blight ; Tuscan varieties ; leaf senescence ; degron ; plant development ; Camellia sinensis ; AtRGS1 ; Prunus avium ; msd ; dammarenediol synthase ; sorghum ; jasmonic acid (JA) signaling pathway ; biological function ; ABA biosynthesis ; MYB transcription factor ; ethylene ; secondary metabolite ; cytokinin ; Nicotiana plants ; grain development ; grain number ; opr3 ; stress defense ; diffusion dynamics ; proline ; crosstalk ; ROS ; bioinformatics ; adventitious rooting ; ginsenoside ; jasmonates ; quantitative proteomics ; signaling ; signal molecules ; MeJA ; hypocotyl ; lipoxygenase ; jasmonic acid ; ancestral sequences ; proteomics ; Ralstonia solanacearum ; Jasmonate-ZIM domain ; signaling pathway ; patchouli alcohol ; volatile ; rice ; ectopic protoxylem ; chlorophyll fluorescence imaging ; type III effector ; fatty acid desaturase ; salt response ; transcriptional regulators ; aroma
    Sprache: Englisch
    Format: application/octet-stream
    Standort Signatur Erwartet Verfügbarkeit
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