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  • Polymer and Materials Science  (69,750)
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  • 1
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    Emerald Publishing | ICE Publishing
    Publication Date: 2024-04-11
    Description: The ebook edition of this title is Open Access and freely available to read online. Specification for Tunnelling, Fourth edition is a standard industry document for tunnelling contracts and forms the basis of tunnelling specifications for projects throughout the world. It reflects current industry best practice and considers technological advancements over the last ten years. It also investigates a range of new topics. Since the publication of the third edition in 2010, the British tunnelling industry has completed several major projects both domestic and abroad. This updated fourth edition captures the many advances made in the field of tunnelling and the lessons learned on these projects through a comprehensive review of all content by subject matter experts. The importance of sustainability and the increased market share of low CO2e materials have been reflected by removal of prescriptive requirements and a strong emphasis on performance-based specification. All references to codes, standards and other design documents have been comprehensively updated. Drafted by an expert editorial committee and supported by multiple rounds of industry-wide peer reviews, the Specification for Tunnelling in its fourth edition will continue to be the de facto standard reference work for tunnelling in the UK and worldwide.
    Keywords: Engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNC Company, commercial and competition law: general::LNCQ Construction and engineering law ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNC Company, commercial and competition law: general::LNCQ Construction and engineering law ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The 3rd International Conference on Advances in Mechanical Engineering 2023 (ICAME-23) was organized on 24th August 2023 by the Department of Mechanical Engineering, Capital University of Science and Technology (CUST). All the articles are single-blindfold reviewed. The acceptance rate of the conference was 65%. ICAME is held annually and welcame high-quality theoretical and empirical original research papers, case studies, and review papers from researchers, academicians, professionals, practitioners, and students worldwide. ICAME-23 accepted research papers in the discipline of: Experimental and Computational Fluid Dynamics; Thermodynamics and heat transfer analysis; Machine and Mechanisms; Design and Solid Mechanics; Manufacturing, Production and Industrial Engineering; Engineering and Technology Management; Renewable Energy and Environmental Engineering; Bioengineering; Materials and Failure Analysis; Other Related Fields. The ICAME-23 conference provided a platform for the national and international speakers/participants to present their state-of-the-art research work to diverse audiences from academia and industry. The conference proceedings are published in the Engineering Proceeding of MDPI, Switzerland. All the articles are individually indexed and are citable via Digital Object Identification (DOI).
    Keywords: Engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials
    Language: English
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  • 3
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-07
    Description: This book provides useful insight into how academics from diverse disciplinary backgrounds, such as science, engineering, technology, social science, policy, design, architecture, built environment, business, and management, have been conducting research into how to realise net zero emissions to address climate change. This book explores the ways in which countries around the world have pledged to achieve net zero emissions through decarbonisation processes. It presents the highest calibre research and impact activities carried out in the UK, Europe, North America, Australia, Asia, and Africa. Such activities include conceptualisation, opportunity identification, specific case studies, demonstration of proof of concepts, provision of evidence, education of the general public, and knowledge transfer to companies. Further to this, the chapters also bring to light personal career journeys to net zero by current and future international research leaders. From this book, readers will gain a full understanding of net zero research via multiple disciplinary pathways, be inspired by personal accounts, and will learn key methodologies, including quantitative and qualitative approaches. The diversity of authors and topics make the book widely applicable to a range of fields, and it will be of great interest to researchers, students, practitioners, and decision makers working towards the goals of net zero and decarbonisation.
    Keywords: Net Zero ; Net Zero emissions ; Decarbonisation ; Climate change ; Interdisciplinary education ; Carbon neutral ; 2050 ; Sustainability ; Sustainable consumption ; Sustainability transitions ; Sustainable fashion ; Engineering ; thema EDItEUR::A The Arts::AB The arts: general topics ; thema EDItEUR::A The Arts::AK Design, Industrial and commercial arts, illustration::AKP Product design ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THV Alternative and renewable energy sources and technology ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNP Pollution and threats to the environment::RNPG Climate change ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RP Regional and area planning::RPC Urban and municipal planning and policy ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTP Development studies ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBC Engineering: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBD Technical design::TBDG Ergonomics ; thema EDItEUR::P Mathematics and Science::PH Physics::PHD Classical mechanics::PHDY Energy ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSD Urban communities ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDP Other manufacturing technologies
    Language: English
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  • 4
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    TU Delft OPEN Publishing
    Publication Date: 2024-03-23
    Description: The Cross Domain City of the Future Graduation Lab, situated in the Faculty of Architecture and the Built Environment at TU Delft, has been a pioneer in experimenting with a multidisciplinary approach to education on the built environment. Drawing upon this expertise over the past years, this book reflects on multidisciplinarity in the built environment and its implementation in education on the built environment. How should one approach multidisciplinarity in education and practice? What encompasses its core elements, benefits, and challenges? By addressing these questions, the book aims to inform students and practitioners within the realm of the built environment by sharing insights from experiences in multidisciplinary education. It presents eight conclusions regarding the future of multidisciplinary education and, thereby, seeks to contribute to a more humane and sustainable future for cities: 1.Process is central to multidisciplinary collaboration. Negotiating positions, ensuring an environment of respect, balance and open-mindedness, and setting a common vocabulary. 2.Multidisciplinarity can be a way to foster innovation. It triggers complementarity and confrontation. As with any innovation, there is potential for greater outcomes, but, at the same time, extra risks emerge. These need to be managed. 3.Multidisciplinarity could be better integrated into organisational structures. 4.Disciplinarity and multidisciplinarity are in mutual coexistence. They are inseparable. They can complement and contradict each other. 5.Problem precedes solution, not the opposite. Framing the problem, or ‘problematizing’, is a considerable share of the actual solution. This is particularly applicable to multidisciplinarity. 6.Multidisciplinarity is by nature composed of fluid boundaries. Navigating through an enormous diversity of perspectives requires agility, flexibility, independence, spirit of adventure and embracing uncertainty. 7.Professionals should be trained as ‘T-shape’: grounded in their field while able to dialogue with other fields. 8.Both generalists and specialists are needed. Education should provide opportunities for both.
    Keywords: City ; Future ; Multidisciplinarity ; Design ; Education ; Engineering ; Graduation Lab ; Built Environment ; Architecture ; Urban Design ; Management ; Geomatics ; Transport ; Infrastructure ; Logistics ; Collaboration ; thema EDItEUR::A The Arts::AM Architecture
    Language: English
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  • 5
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    Amsterdam University Press
    Publication Date: 2024-03-23
    Description: Techne;/Technology offers a penetrating, close look at the origins of the term techne;, which unleashed a revolution in cinema and media studies when it was first introduced and which continues to influence the study of film as the digital revolution rolls along. The contributors investigate the effects of technologies on major film debates and, moreover, how technologies have affected film theory and its key concepts.
    Keywords: Film Studies ; Communication Studies ; Engineering ; thema EDItEUR::A The Arts::AT Performing arts::ATF Films, cinema ; thema EDItEUR::A The Arts::AT Performing arts::ATJ Television ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: English
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  • 6
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    Boydell & Brewer | James Currey an imprint of Boydell & Brewer
    Publication Date: 2024-03-29
    Description: No country has managed to develop beyond a subsistence economy without ensuring at least minimum access to electricity for the majority of its population. Yet many sub-Saharan African countries struggle to meet demand. Why is this, and what can be done to reduce energy poverty and further Africa's development? Examining the politics and processes surrounding electricity infrastructure, provision and reform, the author provides an overview of historical andcontemporary debates about access in the sub-continent, and explores the shifting role and influence of national governments and of multilateral agencies in energy reform decisions. He describes a challenging political environment for electricity supply, with African governments becoming increasingly frustrated with the rules and the processes of multilateral donors. Civil society also began to question reform choices, and governments in turn looked to new development partners, such as China, to chart a fresh path of energy transformation. Drawing on over fifteen years of research on Uganda, which has one of the lowest levels of access to electricity in Africa and has struggled to construct several, large hydroelectric dams on the Nile, Gore argues that there is a critical need to recognize how the changing political and social context in African countries, and globally, has affected the capacity to fulfil national energy goals, minimize energy poverty and transform economies.
    Keywords: Political Science ; African Studies ; Engineering ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::T Technology, engineering, agriculture::TH Energy technology & engineering::THR Electrical engineering::THRB Power generation & distribution ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THY Energy, power generation, distribution and storage
    Language: English
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  • 7
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    CLACSO
    Publication Date: 2024-04-14
    Description: Description not available.
    Keywords: Technology ; Engineering ; Political Science ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics::UBW Internet: general works ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPH Political structure and processes::JPHV Political structures: democracy
    Language: Spanish
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  • 8
    Publication Date: 2024-04-11
    Description: Este libro indaga desde múltiples preguntas y perspectivas las transformaciones provocadas por el incremento descomunal del flujo de información generada por el uso masivo e intensivo de las tecnologías digitales. El estudio de las apropiaciones por parte de la sociedad configura un mosaico desigual y combinado de usos y empleos de las tecnologías digitales. ¿Cómo han impactado en los grupos sociales, económicos y generacionales los usos de las tecnologías? ¿Que desafíos entrañan y que problemas nuevos generan las herramientas cotidianas a través de las cuales conocemos y nos comunicamos con nuestro entorno y el mundo?
    Keywords: Engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering
    Language: Spanish
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  • 9
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    University of Minnesota Press
    Publication Date: 2024-04-04
    Description: An investigation of how-to guides for sensor technologies Sensors are increasingly common within citizen-sensing and DIY projects, but these devices often require the use of a how-to guide. From online instructional videos for troubleshooting sensor installations to handbooks for using and abusing the Internet of Things, the how-to genres and formats of digital instruction continue to expand and develop. As the how-to proliferates, and instructions unfold through multiple aspects of technoscientific practices, Jennifer Gabrys asks why the how-to has become one of the prevailing genres of the digital. How to Do Things with Sensors explores the ways in which things are made do-able with and through sensors and further considers how worlds are made sense-able and actionable through the instructional mode of citizen-sensing projects. Forerunners: Ideas First Short books of thought-in-process scholarship, where intense analysis, questioning, and speculation take the lead
    Keywords: Science & Technology Studies ; General Science ; Engineering ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDA Philosophy of science ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Artificial intelligence is a term that refers to the ability to provide machines with human intelligence. In medicine it is becoming widely used. It finds application especially in the diagnostic and tumor fields. It is not yet able to replace the human brain, but several studies show how its support can be useful in making diagnoses and providing prognoses. This reprint addresses various satellite topics of this discipline, giving practical examples in various clinical fields. In addition, it highlights the strengths of this tool and proposes methods to improve its weaknesses by addressing issues such as increasing data sets and selecting the right features. It also addresses other innovative aspects that together with artificial intelligence can lead to improvements in surgery.
    Keywords: Artificial Intelligence ; Automatic ; Diagnostics ; Engineering ; Imaging ; Machine Learning ; Deep Learning ; Features ; Biomedics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 11
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    Pennsylvania State University Press
    Publication Date: 2024-03-27
    Description: Oil, like other fossil fuels, permeates every aspect of human existence. Yet it has been largely ignored by cultural critics, especially in the context of the Global South. Seeking to make visible not only the pervasiveness of oil in society and culture but also its power, Oil Fictions stages a critical intervention that aligns with the broader goals of the energy humanities.Exploring literature and film about petroleum as a genre of world literature, Oil Fictions focuses on the ubiquity of oil as well as the cultural response to petroleum in postcolonial states. The chapters engage with African, South American, South Asian, Iranian, and transnational petrofictions and cover topics such as the relationship of colonialism to the fossil fuel economy, issues of gender in the Thermocene epoch, and discussions of migration, precarious labor, and the petro-diaspora. This unique exploration includes testimonies of the oil encounter—through memoirs, journals, and interviews—from a diverse geopolitical grid, ranging from the Permian Basin to the Persian Gulf.By engaging with non-Western literary responses to petroleum in a concentrated, sustained way, this pathbreaking book illuminates the transnational dimensions of the discourse on oil. It will appeal to scholars and students working in literature and science studies, energy humanities, ecocriticism, petrocriticism, environmental humanities, and Anthropocene studies.In addition to the editors, the contributors to this volume include Henry Obi Ajumeze, Rebecca Babcock, Ashley Dawson, Sharae Deckard, Scott DeVries, Kristen Figgins, Amitav Ghosh, Corbin Hiday, Helen Kapstein, Micheal Angelo Rumore, Simon Ryle, Sheena Stief, Imre Szeman, Maya Vinai, and Wendy W. Walters.
    Keywords: Language & Literature ; Sustainability ; Engineering ; Environmental Science ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBH Literary studies: c 1900 to c 2000 ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THF Fossil fuel technologies::THFP Petroleum technology ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNF Environmental management
    Language: English
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  • 12
    Publication Date: 2024-04-09
    Description: The role of fossil planktonic foraminifera as markers for biostratigraphical zonation and correlation underpins most drilling of marine sedimentary sequences and is key to hydrocarbon exploration. The first - and only - book to synthesize the whole biostratigraphic and geological usefulness of planktonic foraminifera, Biostratigraphic and Geological Significance of Planktonic Foraminifera unifies existing biostratigraphic schemes and provides an improved correlation reflecting regional biogeographies. Renowned micropaleontologist Marcelle K. Boudagher-Fadel presents a comprehensive analysis of existing data on fossil planktonic foraminifera genera and their phylogenetic evolution in time and space. This important text, now in its Second Edition, is in considerable demand and is now being republished by UCL Press.
    Keywords: Geology ; Paleontology ; Geography ; Agriculture ; Engineering ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBG Geology, geomorphology and the lithosphere ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WN Nature and the natural world: general interest::WNR Rocks, minerals and fossils: general interest ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBX Palaeontology ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBG Geology, geomorphology and the lithosphere::RBGH Stratigraphy ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TV Agriculture and farming ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THF Fossil fuel technologies::THFP Petroleum technology
    Language: English
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  • 13
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    University of Minnesota Press
    Publication Date: 2024-04-04
    Description: Sensors are everywhere. Small, flexible, economical, and computationally powerful, they operate ubiquitously in environments. They compile massive amounts of data, including information about air, water, and climate. Never before has such a volume of environmental data been so broadly collected or so widely available. Grappling with the consequences of wiring our world, Program Earth examines how sensor technologies are programming our environments. As Jennifer Gabrys points out, sensors do not merely record information about an environment. Rather, they generate new environments and environmental relations. At the same time, they give a voice to the entities they monitor: to animals, plants, people, and inanimate objects. This book looks at the ways in which sensors converge with environments to map ecological processes, to track the migration of animals, to check pollutants, to facilitate citizen participation, and to program infrastructure. Through discussing particular instances where sensors are deployed for environmental study and citizen engagement across three areas of environmental sensing, from wild sensing to pollution sensing and urban sensing, Program Earth asks how sensor technologies specifically contribute to new environmental conditions. What are the implications for wiring up environments? How do sensor applications not only program environments, but also program the sorts of citizens and collectives we might become? Program Earth suggests that the sensor-based monitoring of Earth offers the prospect of making new environments not simply as an extension of the human but rather as new "technogeographies" that connect technology, nature, and people.
    Keywords: General Science ; Science & Technology Studies ; Engineering ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDA Philosophy of science ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering
    Language: English
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  • 14
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    CLACSO
    Publication Date: 2024-03-30
    Description: Gustavo Lins Riberio conjuga y tensiona la teoría con el trabajo de campo para desentrañar los significados que atribuyen los trabajadores a la construcción de Brasilia. Ello le permitirá reconstruir una memoria donde caben las penurias, los enojos, las broncas, las injusticias laborales, las solidaridades, las amistades, la familia, las lealtades, los sabores de las comidas, la música, la organización, el sindicato y los conflictos, en un todo desordenado pero legible a luz de la teoría. En definitiva, la experiencia de clase se puede leer en El capital de la esperanza de modo transversal, así como también las contradicciones del capitalismo, las políticas urbanistas, las condiciones de trabajo y demás campos problemáticos que han abordado las ciencias sociales. Las y los invitamos a leer —por primera vez o una vez más— esta obra magistral que nos permite comprender y complejizar la dinámica de la expansión capitalista.
    Keywords: Labor & Employment Relations ; Engineering ; History ; Latin American Studies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCF Labour / income economics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: Spanish
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  • 15
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    TU Delft OPEN Publishing
    Publication Date: 2024-03-29
    Description: Current systems design and decision management methodologies can be single-sided, ignoring or failing to capture the dynamic interplay between multi-stakeholder preferences (‘what they want’) and system performances (‘what they can’). In addition, these methodologies often contain fundamental modelling errors and do not provide single best-fit solutions. This leaves designers or decision-makers without unique answers to their problems. Above all, mainstream higher education primarily applies instructivist and research-based learning methods, and therefore does not adequately prepare students for designing solutions to future complex problems. This book introduces both a state-of-the-art participatory design methodology (Odesys), and a design-based learning concept (ODL), which together overcome the aforementioned issues. Odesys is a pure act of open design integration to confront conflicting socio-technical interests and is the key to unlocking these complexities to deliver socially responsible systems. Odesys’ design engine, the Preferendus, enables stakeholders to cooperatively identify their best-fit design synthesis. It employs a novel optimisation method that maximises the aggregated preferences, integrating sound mathematical and extended U-modelling via open technical-, social-, and purpose cycles. The art of ODL is a constructivist design-based and well-proven learning concept fostering students’ design capabilities to become open and persistent problem solvers. It is a reflective, creative, and engaged learning approach that opens human development and unlocks new knowledge and solutions. The author also introduces new management features such as the corporate social identifier (CSI), the ‘socio-eco’ threefold organization model and U-model based open loop management. Finally, the author places Odesys & ODL within the integrative context of empiricism, rationalism, spiritualism, and constructivism to unite the open design impulse. This book will be of interest to both academics and practitioners working in the field of complex systems design and managerial decision-making, and functions as a textbook on systems design and management for master students from diverse backgrounds.
    Keywords: Management ; Technology ; Engineering ; bic Book Industry Communication::J Society & social sciences::JN Education::JNV Educational equipment & technology, computer-aided learning (CAL) ; thema EDItEUR::J Society and Social Sciences::JN Education::JNV Educational equipment and technology, computer-aided learning (CAL)
    Language: English
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  • 16
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    CLACSO
    Publication Date: 2023-10-05
    Description: En junio del 2014 la comunidad Kukama de Cuninico, fue afectada por el derrame de 2500 barriles de petróleo. Como muchas otras comunidades nativas en la Amazonia, Cuninico está enfrascada en un contexto postdesastre agudizado por la ineficiencia estatal. Las dinámicas intrafamiliares y comunitarias, así como las expectativas a futuro de los que allí viven, han cambiado profundamente. En este contexto son las mujeres las que deben asumir más responsabilidades para enfrentar la crisis.
    Keywords: Environmental Science ; Sustainability ; Engineering ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNK Conservation of the environment ; bic Book Industry Communication::T Technology, engineering, agriculture::TH Energy technology & engineering::THF Fossil fuel technologies::THFP Petroleum technology
    Language: Spanish
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  • 17
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    UJ Press | UJ Press
    Publication Date: 2024-03-29
    Description: The book provides a rich, informative picture of the current state of student engagement evaluation, while also highlighting challenges and opportunities for future advances. A particular strength of this publication is its emphasis on the importance of taking evidence-based decisions, and showing how the South African Survey of Student Engagement (SASSE) can provide the evidence for well-informed changes in policy and practice in order to enhance student success." - Prof Magda Fourie-Malherbe, Stellenbosch University
    Keywords: Academics ; Academic achievement ; Academic advising ; Academic advisors ; Academic challenge ; Academic development ; Academic literacy ; Academic performance ; Academic support ; Access ; Academic staff (also see academics/Lecturers) ; Actionable ; Active learning ; Agency ; Aggregated ; Analyse ; Apply ; Ask questions ; Assessment ; Attitude ; Australasian Survey of Student Engagement (AUSSE) ; Beginning University Survey of Student Engagement (BUSSE) ; Benchmarking ; Bloom’s taxonomy ; Business ; economics and management ; Campus environment ; Capacity ; Career advisors ; Challenges ; Classroom activities ; Classroom Survey of Student Engagement (CLASSE) ; Co-curricular (also see extra-curricular) ; Cognitive ; Cognitive development ; Cognitive educational activities ; Cognitive functions ; Cognitive skills ; Collaborative learning ; Colleges ; Community college ; Comprehensive universities ; Conditional formatting ; Contextual ; Contextual challenges ; Contextualised ; Council on Higher Education (CHE) ; Course (module/subject) ; Critical thinking ; Culture ; Curriculum ; Data ; Data-informed ; Decision-making ; Decolonisation ; Deep learning ; Department chairs (heads of departments) ; Department of Higher Education and Training (DHET) ; Development ; Developmental outcomes ; Diagnostic ; Disaggregating ; Discussions ; Discussion with diverse others ; Dropout ; Education outcomes ; Effective educational behaviours ; Effective educational practices ; Effective leadership ; Effective teaching practices ; Empirical ; Engagement – also see Student Engagement ; Engineering ; Equity ; Equitable outcomes ; Evaluate ; Evidence ; Evidence-based ; Expectations ; Expected academic difficulty ; Expected academic perseverance ; Experiential learning ; Experience with staff ; Extended degree ; Extended curricula ; Extra-curricular (also see co-curricular) ; Financial Stress Scale ; First-generation ; First-year ; Food ; Food insecurity ; Frequency ; Freshman myth ; Gender ; Graduate attributes (Learning outcomes) ; Group work ; Heads of departments ; High-Impact practices ; Higher education outcomes ; Higher-Order Learning ; Holistic ; Humanities ; Incentive ; Indicators ; Innovation ; Innovative ; Instructional paradigm ; Interactions ; Interventions ; Institutional culture ; Institutional performance ; Institutional research ; Institutional researchers ; Institution-wide approaches ; Interpersonal relationships ; Interpersonal skills ; Intersectional ; Intersectionality ; Irish Survey of Student Engagement (ISSE) ; Knowledge ; Knowledge society ; Language ; Law ; Leaders ; Leadership (management/university leadership) ; Learning ; Learning environments ; Learning facilitator ; Learning outcomes ; Learning paradigm ; Learning strategies ; Learning with peers ; Lecturer Survey of Student Engagement (LSSE) ; Lecturers (also see academics/academic staff) ; Librarians ; Management (University leaders and Leadership) ; Mathematics ; Memorisation ; Mentor ; Mentoring ; Mentorship ; Mission ; Module (course/subject) ; Motivation ; National Benchmark Tests (NBT) ; National Benchmark Test Project (NBTP) ; National Development Plan ; National Survey of Student Engagement (NSSE) ; Natural and Agricultural Sciences ; Next Generation of Academics Programme (nGAP) ; Numeracy development ; Off-campus ; On-campus ; Online resources ; Pathways ; Peer learning (also see Tutor) ; Pedagogical approaches ; Pedagogical contexts ; Pedagogical environments ; Pedagogical experiences ; Pedagogical innovation ; Pedagogical practices ; Pedagogical relationship ; Pedagogical responsiveness ; Pedagogies ; Perceived academic preparation ; Perceived preparedness ; Persistence ; Policies ; Policy ; Policy makers ; Practical significance ; Practical work ; Preparing for class ; Professional development ; Professionals ; Professional staff ; Quadrant ; Quality ; Quality assurance ; Quality of interactions ; Quantitative reasoning ; Reflection ; Reflective and integrative learning ; Relationships ; Research ; Responsiveness ; Resources ; Retention ; Science ; engineering and technology ; Self-reflection ; Senior students ; Service learning ; Social sciences ; Socio-economic ; South African Survey(s) of Student Engagement (SASSE) ; Staff development (also academic development and lecturer development) ; Stakeholder ; Strategies ; Statistical ; Student affairs ; Student behaviour ; Student bodies ; Student data ; Student development ; Student engagement ; Student evaluation ; Student financial aid ; Student involvement ; Student learning ; Student life ; Student needs ; Student outcomes ; Student organisations ; Student perspective ; Student participation ; Student performance ; Student persistence ; Student retention ; Student responses ; Student societies ; Student-staff interaction ; Student success ; Student views ; Student voice ; Success rates ; Subject (course/module) ; Support services ; Support staff ; Supportive campus ; Supportive environment ; Synthesise ; Systemic perspective ; Systemic understanding ; Teaching ; Teaching and learning ; Techniques ; Time ; Time management ; Traditional universities ; Transformation ; Transformative ; Transition ; Tutor ; Tutorials ; Undergraduate research ; Underprepared ; United States ; University Capacity Development Grant (University Capacity Development Programme) ; Universities ; Universities of Technology ; University leaders ; Unrealistic ; Well-being ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education
    Language: English
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    University of North Carolina Press
    Publication Date: 2024-04-02
    Description: White working-class conservatives have played a decisive role in American history, particularly in their opposition to social justice movements, radical critiques of capitalism, and government help for the poor and sick. While this pattern is largely seen as a post-1960s development, Poor Man's Fortune tells a different story, excavating the long history of white working-class conservatism in the century from the Civil War to World War II. With a close study of metal miners in the Tri-State district of Kansas, Missouri, and Oklahoma, Jarod Roll reveals why successive generations of white, native-born men willingly and repeatedly opposed labor unions and government-led health and safety reforms, even during the New Deal. With painstaking research, Roll shows how the miners' choices reflected a deep-seated, durable belief that hard-working American white men could prosper under capitalism, and exposes the grim costs of this view for these men and their communities, for organized labor, and for political movements seeking a more just and secure society. Roll's story shows how American inequalities are in part the result of a white working-class conservative tradition driven by grassroots assertions of racial, gendered, and national privilege.
    Keywords: History ; American Studies ; Labor & Employment Relations ; Engineering ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNX Industrial relations, occupational health and safety::KNXN Industrial arbitration and negotiation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTU Mining technology and engineering
    Language: English
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  • 19
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    Springer Nature
    Publication Date: 2021-02-10
    Description: Resilience has become an important topic on the safety research agenda and in organizational practice. Most empirical work on resilience has been descriptive, identifying characteristics of work and organizing activity which allow organizations to cope with unexpected situations. Fewer studies have developed testable models and theories that can be used to support interventions aiming to increase resilience and improve safety. In addition, the absent integration of different system levels from individuals, teams, organizations, regulatory bodies, and policy level in theory and practice imply that mechanisms through which resilience is linked across complex systems are not yet well understood. Scientific efforts have been made to develop constructs and models that present relationships; however, these cannot be characterized as sufficient for theory building. There is a need for taking a broader look at resilience practices as a foundation for developing a theoretical framework that can help improve safety in complex systems. This book does not advocate for one definition or one field of research when talking about resilience; it does not assume that the use of resilience concepts is necessarily positive for safety. We encourage a broad approach, seeking inspiration across different scientific and practical domains for the purpose of further developing resilience at a theoretical and an operational level of relevance for different high-risk industries. The aim of the book is twofold: 1. To explore different approaches for operationalization of resilience across scientific disciplines and system levels. 2. To create a theoretical foundation for a resilience framework across scientific disciplines and system levels. By presenting chapters from leading international authors representing different research disciplines and practical fields we develop suggestions and inspiration for the research community and practitioners in high-risk industries. This book is Open Access under a CC-BY licence. ; Explores different approaches for operationalization of resilience across scientific disciplines and system levels Creates a theoretical foundation for a resilience framework across scientific disciplines and system levels Develops suggestions and inspiration for the research community and practitioners in high-risk industries Presents chapters from leading international authors representing different research disciplines and practical fields
    Keywords: Engineering ; Quality control ; Reliability ; Industrial safety ; Health economics ; Environmental management ; Health informatics ; Organization ; Planning ; Health care management ; Health services administration ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCQ Health economics ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJU Organizational theory & behaviour ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBG Medical equipment & techniques ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNF Environmental management ; bic Book Industry Communication::T Technology, engineering, agriculture::TG Mechanical engineering & materials::TGP Production engineering::TGPR Reliability engineering
    Language: English
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    Springer Nature
    Publication Date: 2024-03-25
    Description: This open access book presents a selection of the best contributions to the Digital Cities 9 Workshop held in Limerick in 2015, combining a number of the latest academic insights into new collaborative modes of city making that are firmly rooted in empirical findings about the actual practices of citizens, designers and policy makers. It explores the affordances of new media technologies for empowering citizens in the process of city making, relating examples of bottom-up or participatory practices to reflections about the changing roles of professional practitioners in the processes, as well as issues of governance and institutional policymaking. ;
    Keywords: Engineering ; Electrical engineering ; Regional planning ; Urban planning ; User interfaces (Computer systems) ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RP Regional and area planning ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYZ Human–computer interaction::UYZG User interface design and usability
    Language: English
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  • 21
    Publication Date: 2024-04-07
    Description: This open access book contains a structured collection of the complete solutions of all essential axisymmetric contact problems. Based on a systematic distinction regarding the type of contact, the regime of friction and the contact geometry, a multitude of technically relevant contact problems from mechanical engineering, the automotive industry and medical engineering are discussed. In addition to contact problems between isotropic elastic and viscoelastic media, contact problems between transversal-isotropic elastic materials and functionally graded materials are addressed, too. The optimization of the latter is a focus of current research especially in the fields of actuator technology and biomechanics. The book takes into account adhesive effects which allow access to contact-mechanical questions about micro- and nano-electromechanical systems. Solutions of the contact problems include both the relationships between the macroscopic force, displacement and contact length, as well as the stress and displacement fields at the surface and, if appropriate, within the half-space medium. Solutions are always obtained with the simplest available method - usually with the method of dimensionality reduction (MDR) or approaches which use the solution of the non-adhesive normal contact problem to solve the respective contact problem.
    Keywords: Engineering ; Mechanics ; Mechanics, Applied ; Mechanics ; Applied mathematics ; Engineering mathematics ; thema EDItEUR::P Mathematics and Science::PH Physics::PHD Classical mechanics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBJ Maths for engineers ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science::TGMD Engineering: Mechanics of solids
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-01-31
    Description: This edited book presents new results in the area of algorithm development for different types of scheduling problems. In eleven chapters, algorithms for single machine problems, flow-shop and job-shop scheduling problems (including their hybrid (flexible) variants), the resource-constrained project scheduling problem, scheduling problems in complex manufacturing systems and supply chains, and workflow scheduling problems are given. The chapters address such subjects as insertion heuristics for energy-efficient scheduling, the re-scheduling of train traffic in real time, control algorithms for short-term scheduling in manufacturing systems, bi-objective optimization of tortilla production, scheduling problems with uncertain (interval) processing times, workflow scheduling for digital signal processor (DSP) clusters, and many more.
    Keywords: QA75.5-76.95 ; QA1-939 ; Scheduling under Resource Constraints ; Enumerative Algorithms ; Scheduling under Uncertainty ; Assembly Scheduling ; Timetabling ; Approximation Algorithms ; Scheduling Problems in Logistics ; Complex Scheduling Problems ; Engineering ; Complexity Issues ; Scheduling Heuristics and Metaheuristics ; Agent Based Scheduling ; Just-in-Time Scheduling ; Real-Time Scheduling ; Scheduling Problems in Segments of a Supply Chain ; Healthcare ; Evolutionary Algorithms ; Energy Management etc. ; Transport ; Vehicle Routing ; Sports
    Language: English
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    Springer Nature
    Publication Date: 2024-04-11
    Description: Automatisiertes Fahren wird aktuell auf allen Ebenen diskutiert. Dieses Open Access Buch greift das Thema aus Sicht des ÖPNV auf und stellt Chancen und Risiken des Einsatzes automatisierter Shuttlebusse im Nahverkehr dar. Am Beispiel Bad Birnbach/Niederbayern wird gezeigt, welche Herausforderungen bei der Einführung eines solchen Services zu erwarten sind und wie diese gelöst werden können. Dabei fokussiert sich das Buch auf die Vermittlung von im Feld erhobenen Daten, z.B. zu technischen Schwierigkeiten, Erfahrungsberichten von Anwohnern und Gästen, Akzeptanz in der Bevölkerung, infrastrukturellen Anforderungen, etc. Konkrete Handlungsempfehlungen für Städteplaner, ÖPNV-Betreiber/-Strategen oder Kommunen, die eine Einführung automatisierter Busse in Erwägung ziehen, runden das Werk ab.
    Keywords: Engineering ; Automotive engineering ; Transportation engineering ; Traffic engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNH Highway and traffic engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TR Transport technology and trades::TRC Automotive technology and trades
    Language: German
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    Taylor & Francis | CRC Press
    Publication Date: 2022-04-28
    Description: As technological advancements widen the scope of applications for biomicroelectromechanical systems (BioMEMS or biomicrosystems), the field continues to have an impact on many aspects of life science operations and functionalities. Because BioMEMS research and development require the input of experts who use different technical languages and come from varying disciplines and backgrounds, scientists and students can avoid potential difficulties in communication and understanding only if they possess a skill set and understanding that enables them to work at the interface of engineering and biosciences. Keeping this duality in mind throughout, BioMEMS: Science and Engineering Perspectives supports and expedites the multidisciplinary learning involved in the development of biomicrosystems. Divided into nine chapters, it starts with a balanced introduction of biological, engineering, application, and commercialization aspects of the field. With a focus on molecules of biological interest, the book explores the building blocks of cells and viruses, as well as molecules that form the self-assembled monolayers (SAMs), linkers, and hydrogels used for making different surfaces biocompatible through functionalization. The book also discusses: Different materials and platforms used to develop biomicrosystems Various biological entities and pathogens (in ascending order of complexity) The multidisciplinary aspects of engineering bioactive surfaces Engineering perspectives, including methods of manufacturing bioactive surfaces and devices Microfluidics modeling and experimentation Device level implementation of BioMEMS concepts for different applications. Because BioMEMS is an application-driven field, the book also highlights the concepts of lab-on-a-chip (LOC) and micro total analysis system (μTAS), along with their pertinence to the emerging point-of-care (POC) and point-of-need (PON) applications.
    Keywords: BioMEMS ; Engineering ; Perspectives ; Science ; bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences ; bic Book Industry Communication::T Technology, engineering, agriculture::TC Biochemical engineering::TCB Biotechnology ; bic Book Industry Communication::M Medicine::MQ Nursing & ancillary services::MQW Biomedical engineering ; bic Book Industry Communication::T Technology, engineering, agriculture::TJ Electronics & communications engineering::TJF Electronics engineering ; bic Book Industry Communication::T Technology, engineering, agriculture::TG Mechanical engineering & materials::TGM Materials science
    Language: English
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: The Frontiers in Chemistry Editorial Office team are delighted to present the inaugural “Frontiers in Chemistry: Rising Stars” article collection, showcasing the high-quality work of internationally recognized researchers in the early stages of their independent careers. All Rising Star researchers featured within this collection were individually nominated by the Journal’s Chief Editors in recognition of their potential to influence the future directions in their respective fields. The work presented here highlights the diversity of research performed across the entire breadth of the chemical sciences, and presents advances in theory, experiment and methodology with applications to compelling problems. This Editorial features the corresponding author(s) of each paper published within this important collection, ordered by section alphabetically, highlighting them as the great researchers of the future. The Frontiers in Chemistry Editorial Office team would like to thank each researcher who contributed their work to this collection. We would also like to personally thank our Chief Editors for their exemplary leadership of this article collection; their strong support and passion for this important, community-driven collection has ensured its success and global impact.
    Keywords: Green and Sustainable Chemistry ; Analytical Chemistry ; Theoretical and Computational Chemistry ; Polymer Chemistry ; Medicinal and Pharmaceutical Chemistry ; Organic Chemistry ; Nanoscience ; Catalysis and Photocatalysis ; Supramolecular Chemistry ; Electrochemistry ; Inorganic Chemistry ; Chemical Biology ; thema EDItEUR::P Mathematics and Science::PD Science: general issues
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    Springer Nature
    Publication Date: 2024-04-11
    Description: This open access book comprises 10 high-level papers on research and innovation within the Flexitranstore Project that were presented at the FLEXITRANSTORE special session organized as part of the 21st International Symposium on High Voltage Engineering. FLEXITRANSTORE (An Integrated Platform for Increased FLEXIbility in smart TRANSmission grids with STORage Entities and large penetration of Renewable Energy Sources) aims to contribute to the development of a pan-European transmission network with high flexibility and high interconnection levels. This will facilitate the transformation of the current energy production mix by hosting an increasing share of renewable energy sources. Novel smart grid technologies, control and storage methods, and new market approaches will be developed, installed, demonstrated, and tested introducing flexibility to the European power system. FLEXITRANSTORE is developing a next-generation Flexible Energy Grid (FEG) that will be integrated into the European Internal Energy Market (IEM) through the valorization of flexibility services. This FEG addresses the capabilities of a power system to maintain continuous service in the face of rapid and large swings in supply or demand. As such, a wholesale market infrastructure and new business models within this integrated FEG must be upgraded for network players, and offer incentives for new ones to join, while at the same time demonstrating new business perspectives for cross-border resource management and energy trading.
    Keywords: Engineering ; Power electronics ; Electronics ; Microelectronics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THR Electrical engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering
    Language: English
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  • 27
    Publication Date: 2024-04-11
    Description: This book covers new advances in the field of impedance spectroscopy including fundamentals, methods and applications. It releases selected extended and peer reviewed scientific contributions from the International Workshop on Impedance Spectroscopy (IWIS 2017) focussing on detailed information about recent scientific research results in electrochemistry and battery research, bioimpedance measurement, sensors, system design, signal processing.
    Keywords: TA1-2040 ; International Workshop on Impedance Spectroscopy ; Engineering ; Electrochemistry and Battery Research ; Bioimpedance Measurement ; Sensors ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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    Taylor & Francis | Routledge
    Publication Date: 2024-03-29
    Description: This timely volume brings together a range of international scholars to analyse cultural, political, and individual factors which contribute to the continued global issue of female underrepresentation in STEM study and careers. Offering a comparative approach to examining gender equity in STEM fields across countries including the UK, Germany, the United States, Hong Kong, Taiwan, South Africa, and China, the volume provides a thematic breakdown of institutional trends and national policies that have successfully improved gender equity in STEM at institutions of higher education. Offering case studies that demonstrate how policies interact with changing social and cultural norms, and impact women’s choices and experiences in relation to the uptake and continuation of STEM study at the undergraduate level, the volume highlights new directions for research and policy to promote gender equity in STEM at school, university, and career levels. Contributing to the United Nations’ (UN) 2030 Agenda for Sustainable Development, this text will benefit researchers, academics, and educators with an interest in science education, higher education, and gender equity in STEM fields. The text will also support further discussion and reflection around multicultural education, educational policy and politics, and the sociology of education more broadly.
    Keywords: Access ; Chilly culture in STEM ; Diversity ; discrimination ; Engineering ; female agency ; Gender equality ; Gender equity ; gendered norms ; gender disparities ; Higher education ; Inclusion ; inequalities ; leaky pipeline in STEM ; Math ; Mathematics ; Minorities ; National Science Foundation (NSF) ; ProActive Network (WEPAN) ; participation ; Science ; STEM ; STEM careers ; STEM education ; STEM labor market ; STEM tertiary education ; STEM workforce ; Sustainable Development Goals ; Technology ; UN SDG ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy
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    Springer Nature
    Publication Date: 2024-04-06
    Description: This open access book presents theoretical framework and sample applications of variant construction. The first part includes the components variant logic, variant measurements, and variant maps, while the second part covers sample applications such as variation with functions, variant stream ciphers, quantum interference, classical/quantum random sequences, whole DNA sequences, and multiple-valued pulse sequences. Addressing topics ranging from logic and measuring foundation to typical applications and including various illustrated maps, it is a valuable guide for theoretical researchers in discrete mathematics; computing-, quantum- and communication scientists; big data engineers; as well as graduate and upper undergraduate students.
    Keywords: Engineering ; Electronic circuits ; Logic design ; Electronic circuits ; Information theory ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBW Applied mathematics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFC Electronics: circuits and components ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYF Computer architecture and logic design
    Language: English
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    Springer Nature
    Publication Date: 2024-03-29
    Description: This open access book presents theoretical and practical research relating to the vast, publicly financed program for the construction of new schools and the reorganization of existing educational buildings in Italy. This transformative process aims to give old buildings a fresh identity, to ensure that facilities are compliant with the new educational and teaching models, and to improve both energy efficiency and structural safety with respect to seismic activity. The book is divided into three sections, the first of which focuses on the social role of the school as a civic building that can serve the needs of the community. Innovations in both design and construction processes are then analyzed, paying special attention to the Building Information Modeling (BIM) strategy as a tool for the integration of different disciplines. The final section is devoted to the built heritage and tools, technologies, and approaches for the upgrading of existing buildings so that they meet the new regulations on building performance. The book will be of interest to all who wish to learn about the latest insights into the challenges posed by, and the opportunities afforded by, a comprehensive school building and renovation program.
    Keywords: Engineering ; Buildings—Design and construction ; Building ; Construction ; Engineering, Architectural ; Energy efficiency ; Building materials ; Materials science ; Schools ; bic Book Industry Communication::J Society & social sciences::JN Education::JNL Schools ; bic Book Industry Communication::T Technology, engineering, agriculture::TG Mechanical engineering & materials::TGM Materials science::TGMT Testing of materials ; bic Book Industry Communication::T Technology, engineering, agriculture::TH Energy technology & engineering ; bic Book Industry Communication::T Technology, engineering, agriculture::TN Civil engineering, surveying & building::TNK Building construction & materials ; thema EDItEUR::J Society and Social Sciences::JN Education::JNL Schools and pre-schools ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science::TGMT Testing of materials ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials
    Language: English
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    University of Ottawa Press / Les Presses de l’Université d’Ottawa
    Publication Date: 2022-04-28
    Description: Canada is a prosperous country, but this prosperity is being stressed by demographics, pressures on the public purse, and low productivity growth. To maintain the nation's high quality of life, prosperity must increase while remaining sustainable. Combining Tom Brzustowski's extensive knowledge of government, industry, and academia, 〈i〉The Way Ahead〈/i〉, articulates a strategy for moving the Canadian economy towards higher-value products based on research and development, describing the practical steps government, industry and academia must take to improve things in the short term and prepare strategically for the long term. He recommends increasing productivity growth by embracing an economy based on innovation, prioritizing research and development, marketing Canadian products internationally, and encouraging entrepreneurial activities in all sectors. Ultimately, increasing prosperity will require a new level of understanding, strategic coherence, and mutual support between the private and public sectors in Canada, a challenge that the author feels Canada is prepared to and absolutely must face.
    Keywords: economy ; canada ; Basic research ; Commodity ; Engineering ; Entrepreneurship ; Gross domestic product ; Research and development ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics
    Language: English
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    Springer Nature
    Publication Date: 2024-04-01
    Description: This open access book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner. Describes construction and application of computational human models including anatomically detailed and subject specific models; Explains new practices in computational human modeling for neuroelectromagnetics, electromagnetic safety, and exposure evaluations; Includes a survey of modern applications for which computational human models are critical; Describes cellular-level interactions between the human body and electromagnetic fields.
    Keywords: Engineering ; Biomedical engineering ; Electronic circuits ; Microwaves ; Optical engineering ; thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFC Electronics: circuits and components ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFN Microwave technology
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  • 33
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    Springer Nature
    Publication Date: 2024-04-16
    Description: The objective of this book is to help at-risk organizations to decipher the “safety cloud”, and to position themselves in terms of operational decisions and improvement strategies in safety, considering the path already travelled, their context, objectives and constraints. What link can be established between safety culture and safety models in order to increase safety within companies carrying out dangerous activities? First, while the term “safety culture” is widely shared among the academic and industrial world, it leads to various interpretations and therefore different positioning when it comes to assess, improve or change it. Many safety theories, concepts, and models coexist today, being more or less appealing and/or directly useful to the industry. How, and based on which criteria, to choose from the available options? These are some of the questions addressed in this book, which benefits from the expertise of its worldwide famous authors in several industrial sectors.
    Keywords: Engineering ; Quality control ; Reliability ; Industrial safety ; Economic sociology ; Industrial psychology ; Industrial organization ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBL Sociology: work and labour ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMJ Occupational and industrial psychology ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCD Economics of industrial organization ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering::TGPR Reliability engineering
    Language: English
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    Purdue University Press
    Publication Date: 2022-05-02
    Description: Engineering design is a fundamental problem-solving model used by the discipline. Effective problem-solving requires the ability to find and incorporate quality information sources. To teach courses in this area effectively, educators need to understand the information needs of engineers and engineering students and their information gathering habits. This book provides essential guidance for engineering faculty and librarians wishing to better integrate information competencies into their curricular offerings. The treatment of the subject matter is pragmatic, accessible, and engaging. Rather than focusing on specific resources or interfaces, the book adopts a process-driven approach that outlasts changing information technologies. After several chapters introducing the conceptual underpinnings of the book, a sequence of contributions go into detail about specific steps in the design process and the information needs for those steps.
    Keywords: Engineering ; Teaching ; design ; engineering ; education ; technology ; learning ; bic Book Industry Communication::J Society & social sciences::JN Education::JNT Teaching skills & techniques
    Language: English
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    Springer Nature
    Publication Date: 2021-02-10
    Description: This open access book explores the strategic importance and advantages of adopting multidisciplinary and multiscalar approaches of inquiry and intervention with respect to the built environment, based on principles of sustainability and circular economy strategies. A series of key challenges are considered in depth from a multidisciplinary perspective, spanning engineering, architecture, and regional and urban economics. These challenges include strategies to relaunch socioeconomic development through regenerative processes, the regeneration of urban spaces from the perspective of resilience, the development and deployment of innovative products and processes in the construction sector in order to comply more fully with the principles of sustainability and circularity, and the development of multiscale approaches to enhance the performance of both the existing building stock and new buildings. The book offers a rich selection of conceptual, empirical, methodological, technical, and case study/project-based research. It will be of value for all who have an interest in regeneration of the built environment from a circular economy perspective.
    Keywords: Engineering ; Buildings—Design and construction ; Building ; Construction ; Engineering, Architectural ; Sociology, Urban ; Economic development—Environmental aspects ; Sustainable development ; Environmental economics ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCN Environmental economics ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNU Sustainability ; bic Book Industry Communication::T Technology, engineering, agriculture::TN Civil engineering, surveying & building::TNK Building construction & materials
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  • 36
    Publication Date: 2024-04-11
    Description: This open access work presents selected results from the European research and innovation project IMPROVE which yielded novel data-based solutions to enhance machine reliability and efficiency in the fields of simulation and optimization, condition monitoring, alarm management, and quality prediction.
    Keywords: Engineering ; Quality control ; Reliability ; Industrial safety ; Robotics ; Automation ; Input-output equipment (Computers) ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering::TGPR Reliability engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFM Automatic control engineering::TJFM1 Robotics ; thema EDItEUR::U Computing and Information Technology::UT Computer networking and communications
    Language: English
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  • 37
    Publication Date: 2021-02-10
    Description: This open access book offers a timely guide to challenges and current practices to permanently plug and abandon hydrocarbon wells. With a focus on offshore North Sea, it analyzes the process of plug and abandonment of hydrocarbon wells through the establishment of permanent well barriers. It provides the reader with extensive knowledge on the type of barriers, their functioning and verification. It then discusses plug and abandonment methodologies, analyzing different types of permanent plugging materials. Last, it describes some tests for verifying the integrity and functionality of installed permanent barriers. The book offers a comprehensive reference guide to well plugging and abandonment (P&A) and well integrity testing. The book also presents new technologies that have been proposed to be used in plugging and abandoning of wells, which might be game-changing technologies, but they are still in laboratory or testing level. Given its scope, it addresses students and researchers in both academia and industry. It also provides information for engineers who work in petroleum industry and should be familiarized with P&A of hydrocarbon wells to reduce the time of P&A by considering it during well planning and construction.
    Keywords: Engineering ; Ocean engineering ; Geotechnical engineering ; Energy policy ; Energy and state ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RB Earth sciences ; bic Book Industry Communication::T Technology, engineering, agriculture::TH Energy technology & engineering ; bic Book Industry Communication::T Technology, engineering, agriculture::TT Other technologies & applied sciences::TTS Marine engineering::TTSH Offshore engineering
    Language: English
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  • 38
    Publication Date: 2024-04-09
    Description: Coding; Communications; Engineering; Networks; Information Theory; Algorithms
    Keywords: Coding ; Communications ; Engineering ; Networks ; Information Theory ; Algorithms ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: English
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  • 39
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    Taylor & Francis
    Publication Date: 2024-04-11
    Description: This modern treatise on compact models for circuit computer-aided design (CAD) presents industry standard models for bipolar-junction transistors (BJTs), metal-oxide-semiconductor (MOS) field-effect-transistors (FETs), FinFETs, and tunnel field-effect transistors (TFETs), along with statistical MOS models. Featuring exercise problems at the end of each chapter and extensive references at the end of the book, the text supplies fundamental and practical knowledge necessary for efficient integrated circuit (IC) design using nanoscale devices. It ensures even those unfamiliar with semiconductor physics gain a solid grasp of compact modeling concepts.
    Keywords: Engineering ; Electrical Engineering ; computer-aided design ; CAD ; compact modeling ; MOSFET ; Circuit Simulation ; compact models ; SPICE model ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFC Electronics: circuits and components
    Language: English
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  • 40
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    Springer Nature
    Publication Date: 2024-04-11
    Description: This open access book presents nine outstanding doctoral dissertations in Information Technology from the Department of Electronics, Information and Bioengineering, Politecnico di Milano, Italy. Information Technology has always been highly interdisciplinary, as many aspects have to be considered in IT systems. The doctoral studies program in IT at Politecnico di Milano emphasizes this interdisciplinary nature, which is becoming more and more important in recent technological advances, in collaborative projects, and in the education of young researchers. Accordingly, the focus of advanced research is on pursuing a rigorous approach to specific research topics starting from a broad background in various areas of Information Technology, especially Computer Science and Engineering, Electronics, Systems and Controls, and Telecommunications. Each year, more than 50 PhDs graduate from the program. This book gathers the outcomes of the nine best theses defended in 2018-19 and selected for the IT PhD Award. Each of the nine authors provides a chapter summarizing his/her findings, including an introduction, description of methods, main achievements and future work on the topic. Hence, the book provides a cutting-edge overview of the latest research trends in Information Technology at Politecnico di Milano, presented in an easy-to-read format that will also appeal to non-specialists.
    Keywords: Engineering ; Electrical engineering ; Control engineering ; Data structures (Computer science) ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFM Automatic control engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMB Algorithms and data structures ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFM Automatic control engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMB Algorithms and data structures
    Language: English
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  • 41
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    Springer Nature
    Publication Date: 2024-04-11
    Description: This open access book, authored by a world-leading researcher in this field, describes fundamentals of dynamic spectrum management, provides a systematic overview on the enabling technologies covering cognitive radio, blockchain, and artificial intelligence, and offers valuable guidance for designing advanced wireless communications systems. This book is intended for a broad range of readers, including students and professionals in this field, as well as radio spectrum policy makers.
    Keywords: Engineering ; Electrical engineering ; Wireless communication systems ; Mobile communication systems ; Computer organization ; Computers ; Artificial intelligence ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications::TJKW WAP (wireless) technology ; thema EDItEUR::U Computing and Information Technology::UT Computer networking and communications ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications::TJKW WAP (wireless) technology ; thema EDItEUR::U Computing and Information Technology::UT Computer networking and communications ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence
    Language: English
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  • 42
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    Springer Nature
    Publication Date: 2024-04-11
    Description: This Open Access proceedings presents new approaches to Machine Learning for Cyber Physical Systems, experiences and visions. It contains some selected papers from the international Conference ML4CPS – Machine Learning for Cyber Physical Systems, which was held in Karlsruhe, October 23-24, 2018. Cyber Physical Systems are characterized by their ability to adapt and to learn: They analyze their environment and, based on observations, they learn patterns, correlations and predictive models. Typical applications are condition monitoring, predictive maintenance, image processing and diagnosis. Machine Learning is the key technology for these developments.
    Keywords: Engineering ; Computational intelligence ; Computer organization ; Electrical engineering ; Data mining ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications ; thema EDItEUR::U Computing and Information Technology::UN Databases::UNF Data mining ; thema EDItEUR::U Computing and Information Technology::UT Computer networking and communications ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications ; thema EDItEUR::U Computing and Information Technology::UN Databases::UNF Data mining ; thema EDItEUR::U Computing and Information Technology::UT Computer networking and communications ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence
    Language: English
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  • 43
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    Springer Nature
    Publication Date: 2021-02-10
    Description: This open access book summarizes research being pursued within the Manutelligence project, the goal of which is to help enterprises develop smart, social and flexible products with high value added services. Manutelligence has improved Product and Service Design by developing suitable models and methods, and connecting them through a modular, collaborative and secure ICT Platform. The use of real data collected in real time by Internet of Things (IoT) technologies underpins the design of product-service systems and makes it possible to monitor them throughout their life cycle. Available data allows costs and sustainability issues to be more accurately measured and simulated in the form of Life Cycle Cost (LCC) and Life Cycle Assessment (LCA). Analysing data from IoT systems and sharing LCC and LCA information via the ICT Platform can help to accelerate the design of product-service systems, reduce costs and better understand customer needs. Industrial partners involved in Manutelligence provide a clear overview of the project’s outcomes, and demonstrate how its technological solutions can be used to improve the design of product-service systems and the management of product-service life cycles.
    Keywords: Engineering ; Manufactures ; Computational intelligence ; Artificial intelligence ; Service industries ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KNS Service industries ; bic Book Industry Communication::T Technology, engineering, agriculture::TG Mechanical engineering & materials::TGP Production engineering ; bic Book Industry Communication::U Computing & information technology::UY Computer science::UYQ Artificial intelligence
    Language: English
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  • 44
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    transcript Verlag
    Publication Date: 2022-05-02
    Description: What role does gender play in scientific research and the development of technologies? This book provides methodological expertise, research experiences and empirical findings in the dynamic field of Science and Technology Studies. The authors, coming from computer science, social sciences, or cultural studies of science, discuss how to ask questions about gender and give examples for the application in interdisciplinary research, development and teaching. Topics range from the design of information and communication technologies, epistemologies of biology and chemistry to teaching mathematics and professional processes in engineering. Contributions by Anne Balsamo, Wendy Faulkner, Rebecca Jordan-Young, Barbara Orland, Els Rommes, and others.
    Keywords: Sociology ; Gender ; Innovation Research ; Science ; Technology ; Engineering ; Gender Studies ; Sociology of Science ; Sociology of Technology ; Cultural Studies ; Sociology ; Gender ; Innovation Research ; Science ; Technology ; Engineering ; Gender Studies ; Sociology of Science ; Sociology of Technology ; Cultural Studies ; Epistemology ; Feminism ; London ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups
    Language: English
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  • 45
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    CRC Press
    Publication Date: 2024-04-11
    Description: This book brings together new developments in the area of strain-engineered MOSFETs using high-mibility substrates such as SIGe, strained-Si, germanium-on-insulator and III-V semiconductors into a single text which will cover the materials aspects, principles, and design of advanced devices, their fabrication and applications. The book presents a full TCAD methodology for strain-engineering in Si CMOS technology involving data flow from process simulation to systematic process variability simulation and generation of SPICE process compact models for manufacturing for yield optimization.
    Keywords: Engineering ; Electrical Engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering
    Language: English
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  • 46
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    Springer Nature
    Publication Date: 2024-04-04
    Description: Dieses Open Access Buch widmet sich dem Problem der Mechanik des Zusammenstoßes zweier makroskopischer Körper. Falls die Dynamik der Körper als Ganzes dies erlaubt, ohne in unüberschaubare Komplexität zu verfallen (in der Regel ist das nur für das reine Normalstoßproblem der Fall), werden allgemeine axialsymmetrische Stoßpartner betrachtet. Für das allgemeine räumliche Stoßproblem wird sich auf den Kontakt von Kugeln beschränkt. Zunächst werden im Buch sehr ausführlich die kontaktmechanischen Grundlagen (Elastizität, Plastizität, Viskoelastizität, Adhäsion, Gradientenmedien) dargestellt und anschließend auf das Stoßproblem übertragen. Mit der Methode der Dimensionsreduktion, der ein eigenes Kapitel gewidmet ist, steht außerdem seit wenigen Jahren ein Werkzeug zu Verfügung, das die sehr effiziente analytische und numerische Behandlung von dynamischen Kontaktproblemen (wie z.B. Stößen) ermöglicht. Den Abschluss des Buch bilden Anwendungsfälle aus verschiedenen Gebieten.
    Keywords: Engineering ; Mechanics ; Mechanics, Applied ; Mechanics ; Applied mathematics ; Engineering mathematics ; bic Book Industry Communication::P Mathematics & science::PH Physics::PHD Classical mechanics ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBJ Maths for engineers ; bic Book Industry Communication::T Technology, engineering, agriculture::TG Mechanical engineering & materials::TGM Materials science::TGMD Mechanics of solids ; thema EDItEUR::P Mathematics and Science::PH Physics::PHD Classical mechanics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBJ Maths for engineers ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science::TGMD Engineering: Mechanics of solids
    Language: German
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  • 47
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    Springer Nature
    Publication Date: 2024-04-11
    Description: Engineering; Industrial engineering; Production engineering
    Keywords: Engineering ; Industrial engineering ; Production engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering
    Language: English
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  • 48
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    Springer Nature
    Publication Date: 2024-04-11
    Description: This open access book contains the research report of the Collaborative Research Center “Micro Cold Forming” (SFB 747) of the University of Bremen, Germany. The topical research focus lies on new methods and processes for a mastered mass production of micro parts which are smaller than 1mm (by forming in batch size higher than one million). The target audience primarily comprises research experts and practitioners in production engineering, but the book may also be of interest to graduate students alike.
    Keywords: Engineering ; Manufactures ; Quality control ; Reliability ; Industrial safety ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering::TGPR Reliability engineering
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  • 49
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    Springer Nature
    Publication Date: 2021-02-10
    Description: This open access book presents work collected through the Liquefaction Experiments and Analysis Projects (LEAP) in 2017. It addresses the repeatability, variability, and sensitivity of lateral spreading observed in twenty-four centrifuge model tests on mildly sloping liquefiable sand. The centrifuge tests were conducted at nine different centrifuge facilities around the world. For the first time, a sufficient number of experiments were conducted to enable assessment of variability of centrifuge test results. The experimental data provided a unique basis for assessing the capabilities of twelve different simulation platforms for numerical simulation of soil liquefaction. The results of the experiments and the numerical simulations are presented and discussed in papers submitted by the project participants. The work presented in this book was followed by LEAP-Asia that included assessment of a generalized scaling law and culminated in a workshop in Osaka, Japan in March 2019. LEAP-2020, ongoing at the time of printing, is addressing the validation of soil-structure interaction analyses of retaining walls involving a liquefiable soil. A workshop is planned at RPI, USA in 2020.
    Keywords: Engineering ; Engineering geology ; Engineering—Geology ; Foundations ; Hydraulics ; Quality control ; Reliability ; Industrial safety ; Geotechnical engineering ; Soil science ; Soil conservation ; Natural disasters ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RB Earth sciences ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RB Earth sciences::RBG Geology & the lithosphere::RBGB Soil science, sedimentology ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RB Earth sciences::RBP Meteorology & climatology ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNR Natural disasters ; bic Book Industry Communication::T Technology, engineering, agriculture::TG Mechanical engineering & materials::TGP Production engineering::TGPR Reliability engineering
    Language: English
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  • 50
    Publication Date: 2024-03-29
    Description: Understanding the many complexities that define gender inequality has been described by researchers as a grand challenge. Novel insights, innovation, a broader community to conduct research and to ascertain effective interventions are essential in the challenge to create organizations that are gender equal. As such, this Research Topic in Frontiers in Psychology addresses the under-representation of women in engineering and computing as a complex, but solvable problem. This Research Topic seeks to inform the global community about advances in understanding the under-representation of women in engineering and computing with a focus on what enables change. Further, this Topic will promote fresh perspectives, innovative methodologies, and mixed method approaches important to accelerating the pace of change.
    Keywords: BF1-990 ; Q1-390 ; Women ; Engineering ; Tech ; Gender Equity ; Under-Represention of Women ; Computing ; STEM ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 51
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    Purdue University Press
    Publication Date: 2024-03-29
    Description: Higher education is coming under increasing scrutiny, both publically and within academia, with respect to its ability to appropriately prepare students for the careers that will make them competitive in the 21st-century workplace. At the same time, there is a growing awareness that many global issues will require creative and critical thinking deeply rooted in the technical STEM (science, technology, engineering, and mathematics) disciplines. Transforming Institutions brings together chapters from the scholars and leaders who were part of the 2011 and 2014 conferences. It provides an overview of the context and challenges in STEM higher education, contributed chapters describing programs and research in this area, and a reflection and summary of the lessons from the many authors’ viewpoints, leading to suggested next steps in the path toward transformation.
    Keywords: Engineering ; Undergraduate ; Education ; Science ; Technology ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy
    Language: English
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  • 52
    Publication Date: 2023-12-20
    Description: This volume features thirteen original chapters on the causes and consequences of gender segregation in scientific, technical, engineering, and mathematics (“STEM”) occupations and fields of study. Although women have made great strides in equalizing access to labor markets and higher education, many STEM fields—particularly in the physical sciences and engineering—remain strongholds of gender segregation in the United States and other reputably gender-progressive societies. Policymakers, business leaders and activists have launched countless initiatives to diversify access to lucrative, high status occupations and ameliorate labor shortages that diminish innovation and competitiveness. Contributors to this volume apply diverse theoretical lenses and methodological approaches to understand the individual, interactional, organizational, and cultural dynamics that drive this segregation in the United States. Results show that the gender composition of scientific and technical fields varies a great deal over time and across organizational contexts and socio-demographic groups defined by race, ethnicity, class, and sexuality. But despite this variability, STEM work and STEM workers are widely presumed to be naturally and inevitably masculine. Research presented here reveals how these stereotypes combine with cultural beliefs about natural and fundamental differences between men and women to produce gendered aspirations and reinforce inequalities in the US scientific and technical workforce.
    Keywords: HM401-1281 ; NX1-820 ; H1-99 ; Women ; Engineering ; Segregation ; Race/ethnicity ; Men ; Sexuality ; Science ; Mathematics ; Gender ; STEM ; Inequality ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFP Social interaction
    Language: English
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  • 53
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-24
    Description: Uncanny computer-generated animations of splashing waves, billowing smoke clouds, and characters’ flowing hair have become a ubiquitous presence on screens of all types since the 1980s. This Open Access book charts the history of these digital moving images and the software tools that make them. Unpredictable Visual Effects uncovers an institutional and industrial history that saw media industries conducting more private R&D as Cold War federal funding began to wane in the late 1980s. In this context studios and media software companies took concepts used for studying and managing unpredictable systems like markets, weather, and fluids and turned them into tools for animation. Unpredictable Visual Effects theorizes how these animations are part of a paradigm of control evident across society, while at the same time exploring what they can teach us about the relationship between making and knowing.
    Keywords: Animation ; Film/TV Industry ; Film Theory ; Film and Television Industry ; Visual Effects ; Live-Action Cinema ; Economics ; Mechanical Control ; Socio-Political ; Engineering ; Open Access ; Animated films ; Performing arts ; Film history, theory & criticism ; thema EDItEUR::A The Arts::AT Performing arts::ATF Films, cinema::ATFV Animated films and animation ; thema EDItEUR::A The Arts::AT Performing arts::ATF Films, cinema ; thema EDItEUR::A The Arts::AT Performing arts::ATJ Television ; thema EDItEUR::A The Arts::AT Performing arts::ATF Films, cinema::ATFA Film history, theory or criticism
    Language: English
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  • 54
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    Springer Nature | Springer
    Publication Date: 2024-04-11
    Description: This open access book presents the proceedings of the 3rd Indo-German Conference on Sustainability in Engineering held at Birla Institute of Technology and Science, Pilani, India, on September 16–17, 2019. Intended to foster the synergies between research and education, the conference is one of the joint activities of the BITS Pilani and TU Braunschweig conducted under the auspices of Indo-German Center for Sustainable Manufacturing, established in 2009. The book is divided into three sections: engineering, education and entrepreneurship, covering a range of topics, such as renewable energy forecasting, design & simulation, Industry 4.0, and soft & intelligent sensors for energy efficiency. It also includes case studies on lean and green manufacturing, and life cycle analysis of ceramic products, as well as papers on teaching/learning methods based on the use of learning factories to improve students’problem-solving and personal skills. Moreover, the book discusses high-tech ideas to help the large number of unemployed engineering graduates looking for jobs become tech entrepreneurs. Given its broad scope, it will appeal to academics and industry professionals alike.
    Keywords: Industrial and Production Engineering ; Renewable and Green Energy ; Engineering/Technology Education ; Study and Learning Skills ; Energy Efficiency ; Energy Policy, Economics and Management ; Engineering and Technology Education ; Engineering ; Entrepreneurship ; Education ; Sustainability ; Learning factories ; International collaboration ; Open Access ; Production engineering ; Alternative & renewable energy sources & technology ; Higher & further education, tertiary education ; Technology: general issues ; Study & learning skills: general ; Energy technology & engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering::THV Alternative and renewable energy sources and technology ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNZ Study and learning skills: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TH Energy technology and engineering
    Language: English
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  • 55
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    Springer Nature
    Publication Date: 2024-04-11
    Description: This open access book summarizes the results of the European research project “Twin-model based virtual manufacturing for machine tool-process simulation and control” (Twin-Control). The first part reviews the applications of ICTs in machine tools and manufacturing, from a scientific and industrial point of view, and introduces the Twin-Control approach, while Part 2 discusses the development of a digital twin of machine tools. The third part addresses the monitoring and data management infrastructure of machines and manufacturing processes and numerous applications of energy monitoring. Part 4 then highlights various features developed in the project by combining the developments covered in Parts 3 and 4 to control the manufacturing processes applying the so-called CPSs. Lastly, Part 5 presents a complete validation of Twin-Control features in two key industrial sectors: aerospace and automotive. The book offers a representative overview of the latest trends in the manufacturing industry, with a focus on machine tools.
    Keywords: Engineering ; Manufactures ; Vibration ; Dynamical systems ; Dynamics ; Control engineering ; Machinery ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGB Mechanical engineering::TGBN Engines and power transmission ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFM Automatic control engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGB Mechanical engineering::TGBN Engines and power transmission ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFM Automatic control engineering
    Language: English
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  • 56
    Publication Date: 2021-02-10
    Description: This open access book focuses on the development of methods, interoperable and integrated ICT tools, and survey techniques for optimal management of the building process. The construction sector is facing an increasing demand for major innovations in terms of digital dematerialization and technologies such as the Internet of Things, big data, advanced manufacturing, robotics, 3D printing, blockchain technologies and artificial intelligence. The demand for simplification and transparency in information management and for the rationalization and optimization of very fragmented and splintered processes is a key driver for digitization. The book describes the contribution of the ABC Department of the Polytechnic University of Milan (Politecnico di Milano) to R&D activities regarding methods and ICT tools for the interoperable management of the different phases of the building process, including design, construction, and management. Informative case studies complement the theoretical discussion. The book will be of interest to all stakeholders in the building process – owners, designers, constructors, and faculty managers – as well as the research sector.
    Keywords: Engineering ; Buildings—Design and construction ; Building ; Construction ; Engineering, Architectural ; Computer-aided engineering ; Building—Superintendence ; Construction industry—Management ; Construction superintendence ; Remote sensing ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGW Geographical information systems (GIS) & remote sensing ; bic Book Industry Communication::T Technology, engineering, agriculture::TN Civil engineering, surveying & building::TNK Building construction & materials ; bic Book Industry Communication::T Technology, engineering, agriculture::TN Civil engineering, surveying & building::TNT Building skills & trades ; bic Book Industry Communication::U Computing & information technology::UG Graphical & digital media applications::UGC Computer-aided design (CAD)
    Language: English
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  • 57
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    Springer Nature
    Publication Date: 2024-04-11
    Description: In diesem Open-Access-Tagungsband sind die besten Beiträge des 9. Jahreskolloquiums "Kommunikation in der Automation" (KommA 2018) und des 6. Jahreskolloquiums "Bildverarbeitung in der Automation" (BVAu 2018) enthalten. Die Kolloquien fanden am 20. und 21. November 2018 in der SmartFactoryOWL, einer gemeinsamen Einrichtung des Fraunhofer IOSB-INA und der Technischen Hochschule Ostwestfalen-Lippe statt. Die vorgestellten neuesten Forschungsergebnisse auf den Gebieten der industriellen Kommunikationstechnik und Bildverarbeitung erweitern den aktuellen Stand der Forschung und Technik. Die in den Beiträgen enthaltenen anschaulichen Beispiele aus dem Bereich der Automation setzen die Ergebnisse in den direkten Anwendungsbezug.
    Keywords: Engineering ; Electrical engineering ; Signal processing ; Image processing ; Speech processing systems ; Robotics ; Automation ; Quality control ; Reliability ; Industrial safety ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering::TGPR Reliability engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering::TJFM Automatic control engineering::TJFM1 Robotics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTB Applied optics::TTBM Imaging systems and technology
    Language: English , German
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  • 58
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    Springer Nature
    Publication Date: 2021-02-10
    Description: This open access book addresses several questions regarding the implementation of human and organisational factors (HOF) so that recent improvements in industrial safety can be built upon. It addresses sources of frustration in senior management with high expectations of operational recommendations and disquiet on the part of HOF specialists struggling to have an impact on high-level decision making. The brief explores these issues with an emphasis on examples and lessons learned based on the experience of its authors, who come from different academic disciplines and various industrial sectors such as oil and gas, energy and transportation. It then offers some ways forward for a better consideration of HOF in hazardous companies with a view of promoting safety and facing challenges in a rapidly changing world.
    Keywords: Engineering ; Engineering economics ; Engineering economy ; Industrial psychology ; Economic sociology ; Welfare economics ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBL Sociology: work & labour ; bic Book Industry Communication::J Society & social sciences::JM Psychology::JMJ Occupational & industrial psychology ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCA Economic theory & philosophy ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBC Engineering: general
    Language: English
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  • 59
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    Springer Nature
    Publication Date: 2024-03-26
    Description: Dieses Buch ist eine Open-Access-Publikation unter einer CC BY 4.0 Lizenz. Künstliche Intelligenz (KI) klingt in aktuellen Debatten oft abstrakt und alltagsfremd. Doch die meisten Internetnutzerinnern und -nutzer sind bereits täglich mit ihr konfrontiert – wenn auch unbewusst: sei es bei der Sprachsteuerung des Smartphones, bei Kaufempfehlungen im Online-Shop oder bei der Abfrage von auf Webseiten häufig gestellten Fragen (Frequently Asked Questions, FAQ). KI ist ein Teilaspekt der Digitalisierung, der als Schlagwort immer häufiger in den Medien auftaucht. Das aktuell große Interesse liegt darin begründet, dass es in den vergangenen Jahren verschiedene technologische Fortschritte gab, welche die Nutzung der KI nun auf andere Ebenen heben. Mit diesem Themenband des Instituts für Innovation und Technik (iit) „Künstliche Intelligenz“ erhalten Leserinnen und Leser einen schlaglichtartigen Einblick in die KI hinsichtlich ihrer Technologien, aktuellen und potenziellen Anwendungen sowie Auswirkungen auf die Gesellschaft.
    Keywords: Engineering ; Electrical engineering ; Humanities—Digital libraries ; Educational technology ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::J Society and Social Sciences::JN Education::JNV Educational equipment and technology, computer-aided learning (CAL) ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJK Communications engineering / telecommunications
    Language: German
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  • 60
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    Springer Nature
    Publication Date: 2024-04-11
    Description: It is common for us today to associate the practice of science primarily with the act of seeing—with staring at computer screens, analyzing graphs, and presenting images. We may notice that physicians use stethoscopes to listen for disease, that biologists tune into sound recordings to understand birds, or that engineers have created Geiger tellers warning us for radiation through sound. But in the sciences overall, we think, seeing is believing. This open access book explains why, indeed, listening for knowledge plays an ambiguous, if fascinating, role in the sciences. For what purposes have scientists, engineers and physicians listened to the objects of their interest? How did they listen exactly? And why has listening often been contested as a legitimate form of access to scientific knowledge? This concise monograph combines historical and ethnographic evidence about the practices of listening on shop floors, in laboratories, field stations, hospitals, and conference halls, between the 1920s and today. It shows how scientists have used sonic skills—skills required for making, recording, storing, retrieving, and listening to sound—in ensembles: sets of instruments and techniques for particular situations of knowledge making. Yet rather than pleading for the emancipation of hearing at the expense of seeing, this essay investigates when, how, and under which conditions the ear has contributed to science dynamics, either in tandem with or without the eye.
    Keywords: Engineering ; Acoustical engineering ; Technology—History ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTA Acoustic and sound engineering
    Language: English
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  • 61
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    De Gruyter
    Publication Date: 2024-04-11
    Description: This book covers new advances in the field of impedance spectroscopy including fundamentals, methods and applications. It releases selected extended and peer reviewed scientific contributions from the International Workshop on Impedance Spectroscopy (IWIS 2017) focussing on detailed information about recent scientific research results in electrochemistry and battery research, bioimpedance measurement, sensors, system design, signal processing.
    Keywords: Engineering ; International Workshop on Impedance Spectroscopy ; Electrochemistry and Battery Research ; Bioimpedance Measurement ; Sensors ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBM Instruments and instrumentation::TBMM Engineering measurement and calibration
    Language: English
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  • 62
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    Springer Nature
    Publication Date: 2024-03-25
    Description: The conventional approach to risk communication, based on a centralized and controlled model, has led to blatant failures in the management of recent safety related events. In parallel, several cases have proved that actors not thought of as risk governance or safety management contributors may play a positive role regarding safety. Building on these two observations and bridging the gap between risk communication and safety practices leads to a new, more societal perspective on risk communication, that allows for smart risk governance and safety management. This book is Open Access under a CC-BY licence.
    Keywords: Engineering ; Quality control ; Reliability ; Industrial safety ; Operations research ; Management science ; Communication ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTC Communication studies ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJT Operational research ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering::TGPR Reliability engineering
    Language: English
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  • 63
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    Springer Nature
    Publication Date: 2024-04-07
    Description: This open access book provides a concise explanation of the fundamentals and background of the surround sound recording and playback technology Ambisonics. It equips readers with the psychoacoustical, signal processing, acoustical, and mathematical knowledge needed to understand the inner workings of modern processing utilities, special equipment for recording, manipulation, and reproduction in the higher-order Ambisonic format. The book comes with various practical examples based on free software tools and open scientific data for reproducible research. The book’s introductory section offers a perspective on Ambisonics spanning from the origins of coincident recordings in the 1930s to the Ambisonic concepts of the 1970s, as well as classical ways of applying Ambisonics in first-order coincident sound scene recording and reproduction that have been practiced since the 1980s. As, from time to time, the underlying mathematics become quite involved, but should be comprehensive without sacrificing readability, the book includes an extensive mathematical appendix. The book offers readers a deeper understanding of Ambisonic technologies, and will especially benefit scientists, audio-system and audio-recording engineers. In the advanced sections of the book, fundamentals and modern techniques as higher-order Ambisonic decoding, 3D audio effects, and higher-order recording are explained. Those techniques are shown to be suitable to supply audience areas ranging from studio-sized to hundreds of listeners, or headphone-based playback, regardless whether it is live, interactive, or studio-produced 3D audio material.
    Keywords: Engineering ; Signal processing ; Image processing ; Speech processing systems ; Acoustical engineering ; Acoustics ; Music ; thema EDItEUR::A The Arts::AV Music ; thema EDItEUR::P Mathematics and Science::PH Physics::PHD Classical mechanics::PHDS Wave mechanics (vibration and acoustics) ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTA Acoustic and sound engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTB Applied optics::TTBM Imaging systems and technology
    Language: English
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  • 64
    ISSN: 0006-3525
    Keywords: folding type-specific secondary structure propensities ; amino acids ; α-helical proteins ; β sheet proteins ; α/β proteins ; α+β proteins ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Folding type-specific secondary structure propensities of 20 naturally occurring amino acids have been derived from α-helical, β-sheet, α/β, and α+β proteins of known structures. These data show that each residue type of amino acids has intrinsic propensities in different regions of secondary structures for different folding types of proteins. Each of the folding types shows markedly different rank ordering, indicating folding type-specific effects on the secondary structure propensities of amino acids. Rigorous statistical tests have been made to validate the folding type-specific effects. It should be noted that α and β proteins have relatively small α-helices and β-strands forming propensities respectively compared with those of α+β and α/β proteins. This may suggest that, with more complex architectures than α and β proteins, α+β and α/β proteins require larger propensities to distinguish from interacting α-helices and β-strands. Our finding of folding type-specific secondary structure propensities suggests that sequence space accessible to each folding type may have differing features. Differing sequence space features might be constrained by topological requirement for each of the folding types. Almost all strong β-sheet forming residues are hydrophobic in character regardless of folding types, thus suggesting the hydrophobicities of side chains as a key determinant of β-sheet structures. In contrast, conformational entropy of side chains is a major determinant of the helical propensities of amino acids, although other interactions such as hydrophobicities and charged interactions cannot be neglected. These results will be helpful to protein design, class-based secondary structure prediction, and protein folding. © 1998 John Wiley & Sons, Inc. Biopoly 45: 35-49, 1998
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  • 65
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    Biopolymers 45 (1998), S. 69-83 
    ISSN: 0006-3525
    Keywords: DNA branched junctions ; branch migration ; superhelical torque ; control of DNA structure ; endonuclease VII ; nanomechanical device ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: DNA branched junctions are analogues of Holliday junction recombination intermediates. Partially mobile junctions contain a limited amount of homology flanking the branch point. A partially mobile DNA branched junction has been incorporated into a synthetic double-stranded circular DNA molecule. The junction is flanked by four homologous nucleotide pairs, so that there are five possible locations for the branch point. Two opposite arms of the branched junction are joined to form the circular molecule, which contains 262 nucleotides to the base of the junction. This molecule represents a system whereby torque applied to the circular molecule can have an impact on the junction, by relocating its branch point. Ligation of the molecule produces two topoisomers; about 87% of the product is a relaxed molecule, and the rest is a molecule with one positive supercoil. The position of the branch point is assayed by cleaving the molecule with endonuclease VII. We find that the major site of the branch point in the relaxed topoisomer is at the maximally extruded position in the relaxed molecule. Upon the addition of ethidium, the major site of the branch point migrates to the minimally extruded position. © 1998 John Wiley & Sons, Inc. Biopoly 45: 69-83, 1998
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  • 66
    ISSN: 0006-3525
    Keywords: conformation ; aggregation ; κ-carrageenan ; flow field-flow fractionation ; multiangle light scattering ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The relatively novel combination of flow field-flow fractionation (FFF) and multiangle light scattering (MALS) was employed to study a nondegraded κ-carrageenan in different 0.1M salt solutions. The applicability of the technique was tested, and the effects of salt type and salt composition on the molar mass and radius of gyration were studied. A conformational ordering was induced at room temperature by switching the solvent from 0.1M NaCl (coil form) to 0.1M NaI (helix form). An approximate doubling of the average molar mass and an increase in radius of gyration was then observed, in agreement with results obtained previously using size exclusion chromatography-MALS. This increase in size was attributed to conformational ordering and to the formation of double helices. Severe aggregation was observed above 40% CsI in the 0.1M mixed salt solution of CsI and NaI. This was ascribed to the association of helices into large aggregates. For these large associates, having molar masses of several millions, a reversal of the elution order in flow FFF was detected. © 1998 John Wiley & Sons, Inc. Biopoly 45: 85-96 1998
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  • 67
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    Biopolymers 45 (1998), S. 119-133 
    ISSN: 0006-3525
    Keywords: conformations of D-alanyl-D-alanine ; β-lactam ; structural overlay ; AMBER force field ; AM1 ; ab initio ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In this article a conformational analysis of the D-alanyl-D-alanine dipeptide, both charged and neutral, has been carried out. The preferred conformations were determined by means of ab initio and semiempirical quantum, together with empirical force field calculations. The AMBER* force field and the 6-31 + G** and 6-31G** ab initio levels give rise to a coincident minimum energy structure, which, on the other hand, differs from that determined by AM1, 3-21 + G, and 3-21G. The solvent effect on the different charged and neutral conformations have been considered through the AMSOL semiempirical method. A quantification regarding the structural similarities between the different dipeptide conformations and the ampicillin has been performed. The results show that the best overlay is attained by the minimum structure energy obtained by using the 6-31 + G** methodology, which presents a planar amidic nitrogen. © 1998 John Wiley & Sons, Inc. Biopoly 45: 119-133, 1998
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  • 68
    ISSN: 0006-3525
    Keywords: chemical oxidation ; cellulose ; conformational transition ; capillary viscosity ; microcalorimetry ; calcium ions ; gels ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The conformational behavior of different molecular weight fractions of a synthetic C6-oxidized derivative of cellulose were investigated by means of capillary viscometry, CD, and microcalorimetric measurements. Experiments were carried out in the presence of either monovalent or divalent counterions.The experimental data indicated that C6-oxidized cellulose can assume an ordered extended conformation at low ionic strength, induced by the intrachain repulsions of negative charges. This conformation was suggested to be very similar to the fully extended structure of cellulose. In addition to this, upon increasing the ionic strength, a conformational transition of the order-to-disorder type occurred. In fact, the screening of the electrostatic repulsions introduced a number of conformational kinks into the cellulosic backbone, which enabled the polymer to assume a more coiled conformation hence producing less viscous aqueous solutions. © 1998 John Wiley & Sons, Inc. Biopoly 45: 157-163, 1998
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  • 69
    ISSN: 0006-3525
    Keywords: conformational stability ; biological polyelectrolytes ; enthalpy ; entropy ; conformational transitions ; carrageenan ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A new method is proposed for the determination of the enthalpy and entropy changes of nonionic origin upon conformational transition of linear biopolyelectrolytes in solution. For all transition midpoints, defined by given temperature and ionic strength, the total free energy change of the system is zero, which means that the nonionic contribution to the free energy change is equal in value and opposite in sign to the polyelectrolytic one. The counterion condensation theory of linear polyelectrolytes provides for the appropriate analytical expression to be used in such calculations. Linear plots of the proper functions of the calculated free energy changes vs the proper functions of temperature allows for the determination of the enthalpic and entropic terms of the nonionic free energy change of transition.The method has been applied to the extensive available data of the ion-induced conformational change of κ-carrageenan, a linear sulfated galactan extracted from seaweeds. The method has proved very successful, with the results showing a remarkable convergency of the enthalpy values for different monovalent counterions. On the other hand, the above approach has made it possible to explain the known effect of counterion specificity on the transition by a small difference in the nonionic entropic contributions. © 1998 John Wiley & Sons, Inc. Biopoly 45: 203-216, 1998
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  • 70
    ISSN: 0006-3525
    Keywords: uv resonance Raman spectroscopy ; Raman cross section ; hypochromism ; DNA ; deoxynucleoside ; protein ; aromatic amino acid ; virus assembly ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ultraviolet resonance Raman (UVRR) spectra of H2O and D2O solutions of the nucleoside (dA, dG, dC, dT) and aromatic amino acid (Phe, Trp, Tyr) constituents of DNA viruses have been obtained with laser excitation wavelengths of 257, 244, 238, and 229 nm. Using the 981 cm-1 marker of Na2SO4 as an internal standard, Raman frequencies and scattering cross sections were evaluated for all prominent UVRR bands at each excitation wavelength. The results show that UVRR cross sections of both the nucleosides and amino acids are strongly dependent on excitation wavelength and constitute sensitive and selective probes of the residues. The results provide a library of UVRR marker bands for structural analysis of DNA viruses and other nucleoprotein assemblies. © 1998 John Wiley & Sons, Inc. Biopoly 45: 247-256, 1998
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  • 71
    ISSN: 0006-3525
    Keywords: hemoglobin ; hexagonal bilayer ; Lumbricus ; electron microscopy ; three-dimensional reconstruction ; small-angle x-ray scattering ; three-dimensional models ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The quaternary structure of Lumbricus terrestris hemoglobin was investigated by small-angle x-ray scattering (SAXS). Based on the SAXS data from several independent experiments, a three-dimensional (3D) consensus model was established to simulate the solution structure of this complex protein at low resolution (about 3 nm) and to yield the particle dimensions. The model is built up from a large number of small spheres of different weights, a result of the two-step procedure used to calculate the SAXS model. It accounts for the arrangement of 12 subunits in a hexagonal bilayer structure and for an additional central unit of cylinder-like shape. This model provides an excellent fit of the experimental scattering curve of the protein up to h = 1 nm-1 and a nearly perfect fit of the experimental distance distribution function p(r) in the whole range. Scattering curves and p(r) functions were also calculated for low-resolution models based on 3D reconstructions obtained by cryoelectron microscopy (EM). The calculated functions of these models also provide a very good fit of the experimental scattering curve (even at h 〉 1 nm-1) and p(r) function, if hydration is taken into account and the original model coordinates are slightly rescaled. The comparison of models reveals that both the SAXS-based and the EM-based model lead to a similar simulation of the protein structure and to similar particle dimensions. The essential differences between the models concern the hexagonal bilayer arrangement (eclipsed in the SAXS model, one layer slightly rotated in the EM model), and the mass distribution, mainly on the surface and in the central part of the protein complex. © John Wiley & Sons, Inc. Biopoly 45: 289-298, 1998
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  • 72
    ISSN: 0006-3525
    Keywords: conformational changes ; vicinal glycosylation ; branched α-l-Rhap(1-2)[β-d-Galp(1-3)]-β-d-Glc1-OMe trisaccharide ; parent disaccharides ; hydrogen bond ; isotope effect ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Conformations of the α-l-Rhap(1-2)-β-d-Glc1-OMe and β-d-Galp(1-3)-β-d-Glc1-OMe disaccharides and the branched title trisaccharide were examined in DMSO-d6 solution by 1H-nmr. The distance mapping procedure was based on rotating frame nuclear Overhauser effect (NOE) constraints involving C- and O-linked protons, and hydrogen-bond constraints manifested by the splitting of the OH nmr signals for partially deuteriated samples. An “isotopomer-selected NOE” method for the unequivocal identification of mutually hydrogen-bonded hydroxyl groups was suggested. The length of hydrogen bonds thus detected is considered the only one motionally nonaveraged nmr-derived constraint. Molecular mechanics and molecular dynamics methods were used to model the conformational properties of the studied oligosaccharides. Complex conformational search, relying on a regular Φ,Ψ-grid based scanning of the conformational space of the selected glycosidic linkage, combined with simultaneous modeling of different allowed orientations of the pendant groups and the third, neighboring sugar residue, has been carried out. Energy minimizations were performed for each member of the Φ,Ψ grid generated set of conformations. Conformational clustering has been done to group the minimized conformations into families with similar values of glycosidic torsion angles. Several stable syn and anti conformations were found for the 1→2 and 1→3 bonds in the studied disaccharides. Vicinal glycosylation affected strongly the occupancy of conformational states in both branches of the title trisaccharide. The preferred conformational family of the trisaccharide (with average Φ,Ψ values of 38°, 17° for the 1→2 and 48°, 1° for the 1→3 bond, respectively) was shown by nmr to be stabilized by intramolecular hydrogen bonding between the nonbonded Rha and Gal residues. © 1998 John Wiley & Sons, Inc. Biopoly 46: 417-432, 1998
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  • 73
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    Biopolymers 46 (1998), S. 489-492 
    ISSN: 0006-3525
    Keywords: refractive index increment ; proteins ; solvent ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The refractive index increment of a protein solution is a property not only of the protein, but also of the solvent. This is demonstrated theoretically and confirmed experimentally using analytical interferometry. © 1998 John Wiley & Sons, Inc. Biopoly 46: 489-492, 1998
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  • 74
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    Biopolymers 47 (1998), S. 1-1 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract.
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  • 75
    ISSN: 0006-3525
    Keywords: hepatitis A ; synthetic peptides ; CD ; liposomes ; computational study ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The present study was undertaken to examine the structural features that may be important to explain the immunogenicity of the (110-121) peptide sequence (FWRGDLVFDFQV) of VP3 capsid protein of hepatitis A virus. A conformational analysis of the preferred conformations by CD and molecular mechanics was carried out. Present results suggest that the interaction with liposomes as biomembrane model induces and stabilizes the amphipathic β-structure of the peptide.To study the contribution of amino acid replacements at the RGD tripeptide as well as the influence of the peptide chain length on peptide conformation, solid-phase peptide synthesis of several peptide analogs was carried out and the peptide conformation was studied using CD spectroscopy. The results show that the RGD sequence is necessary to induce the β-structure in the presence of liposomes. © 1998 John Wiley & Sons, Inc. Biopoly 45: 479-492, 1998
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  • 76
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    Biopolymers 46 (1998), S. 31-37 
    ISSN: 0006-3525
    Keywords: DNA liquid crystals ; DNA fragments ; screened Coulomb interactions ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The critical volume fractions pertaining to the formation of DNA liquid crystals were obtained from polarization microscopy, 31P-nmr, and phase separation experiments. The DNA length (approximately one to two times the persistence length 50 nm), ionic strength, and counterion variety dependencies are reported. The cholesteric-isotropic transition is interpreted in terms of the coexistence equations, which are derived from the solution free energy including orientational entropy and excluded volume effects. With the wormlike chain as reference system, the electrostatic contribution to the free energy is evaluated as a thermodynamic perturbation in the second virial approximation with a Debye-Hückel potential of mean force. The hard core contribution has been evaluated with scaled particle theory and/or a simple generalization of the Carnahan-Starling equation of state for hard spheres. For sufficiently high ionic strengths, the agreement is almost quantitative. At lower amounts of added salt deviations are observed, which are tentatively attributed to counterion screening effects. The contour length dependence agrees with a DNA persistence length 50 nm. © 1998 John Wiley & Sons, Inc. Biopoly 46: 31-37, 1998
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  • 77
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    Biopolymers 46 (1998), S. 245-252 
    ISSN: 0006-3525
    Keywords: gelatin ; gelation ; atomic force microscopy ; interfacial rheology ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Gelation of gelatin under various conditions has been followed by atomic force microscopy (AFM) with the objective of understanding more fully the structure formed during the gelation process. AFM images were obtained of the structures formed from both the bulk sol and in surface films during the onset of gelation. While gelation occurred in the bulk sol, the extent of helix formation was monitored by measurements of optical rotation, and the molecular aggregation was imaged by AFM. Interfacial gelatin films formed at the air-water interface were also studied. Measurements of surface tension and surface rheology were made periodically and Langmuir-Blodgett films were drawn from the interface to allow AFM imaging of the structure of the interfacial layer as a function of time. Structural studies reveal that at low levels of helical content the gelatin molecules assemble into aggregates containing short segments of dimensions comparable to those expected for gelatin triple helices. With time larger fibrous structures appear whose dimensions suggest that they are bundles of triple helices. As gelation proceeds, the number density of fibers increases at the expense of the smaller aggregates, eventually assembling into a fibrous network. The gel structure appears to be sensitive to the thermal history, and this is particularly important in determining the structure and properties of the interfacial films. © 1998 John Wiley & Sons, Inc. Biopoly 46: 245-252, 1998
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  • 78
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    Biopolymers 48 (1998), S. 65-81 
    ISSN: 0006-3525
    Keywords: nucleotide analogue interference mapping ; phosphorothioate ; group I intron ; interference suppression ; RNA ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In this review I will outline several chemogenetic approaches used to determine the chemical basis of large ribozyme function and structure. The term chemogenetics was first used to describe site-specific functional group modification experiments in the analysis of DNA-protein interactions. Within the past few years equivalent experiments have been performed on large catalytic RNAs using both single-site substitution and interference mapping techniques with nucleotide analogues. While functional group mutagenesis is an important aspect of a chemogenetic approach, chemical correlates to genetic revertants and suppressors must also be realized for the genetic analogy to be intellectually valid and experimentally useful. Several examples of functional group revertants and suppressors have now been obtained within the Tetrahymena group I ribozyme. These experiments define an ensemble of tertiary hydrogen bonds that have made it possible to construct a detailed model of the ribozyme catalytic core. The model includes a functionally important monovalent metal ion binding site, a wobble-wobble receptor motif for helix-helix packing interactions, and a minor groove triple helix. © 1998 John Wiley & Sons, Inc. Biopoly 48: 65-81, 1998
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  • 79
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    Biopolymers 48 (1998), S. 83-96 
    ISSN: 0006-3525
    Keywords: nucleic acid ; disulfide cross-link ; structure ; dynamics ; stability ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In this review I discuss straightforward and general methods to modify nucleic acid structure with disulfide cross-links. A motivating factor in developing this chemistry was the notion that disulfide bonds would be excellent tools to probe the structure, dynamics, thermodynamics, folding, and function of DNA and RNA, much in the way that cystine cross-links have been used to study proteins. The chemistry described has been used to synthesize disulfide cross-linked hairpins and duplexes, higher order structures like triplexes, nonground-state conformations, and tRNAs. Since the cross-links form quantitatively by mild air oxidation and do not perturb either secondary or tertiary structure, this modification should prove quite useful for the study of nucleic acids. © 1998 John Wiley & Sons, Inc. Biopoly 48: 83-96, 1998
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  • 80
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    Biopolymers 48 (1998), S. 113-135 
    ISSN: 0006-3525
    Keywords: divalent cations ; magnesium ; RNA ; ion binding ; RNA folding ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Divalent cations, like magnesium, are crucial for the structural integrity and biological activity of RNA. In this article, we present a picture of how magnesium stabilizes a particular folded form of RNA. The overall stabilization of RNA by Mg2+ is given by the free energy of transferring RNA from a reference univalent salt solution to a mixed salt solution. This term has favorable energetic contributions from two distinct modes of binding: diffuse binding and site binding. In diffuse binding, fully hydrated Mg ions interact with the RNA via nonspecific long-range electrostatic interactions. In site binding, dehydrated Mg2+ interacts with anionic ligands specifically arranged by the RNA fold to act as coordinating ligands for the metal ion. Each of these modes has a strong coulombic contribution to binding; however, site binding is also characterized by substantial changes in ion solvation and other nonelectrostatic contributions. We will show how these energetic differences can be exploited to experimentally distinguish between these two classes of ions using analyses of binding polynomials. We survey a number of specific systems in which Mg2+-RNA interactions have been studied. In well-characterized systems such as certain tRNAs and some rRNA fragments these studies show that site-bound ions can play an important role in RNA stability. However, the crucial role of diffusely bound ions is also evident. We emphasize that diffuse binding can only be described rigorously by a model that accounts for long-range electrostatic forces. To fully understand the role of magnesium ions in RNA stability, theoretical models describing electrostatic forces in systems with complicated structures must be developed. © 1999 John Wiley & Sons, Inc. Biopoly 48: 113-135, 1998
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  • 81
    ISSN: 0006-3525
    Keywords: 1H-nmr ; molecular modeling ; peptaibol ; peptide-lipid interaction ; sodium dodecyl sulfate micelles ; trichorzianin TA VII ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Trichorzianin TA VII, Ac0 U1 A2 A3 U4 J5 Q6 U7 U8 U9 S10 L11 U12 P13 V14 U15 I16 Q17 Q18 Fol19, is a nonadecapeptide member of the peptaibol antibiotics biosynthesized by Trichoderma soil fungi, which is characterized by a high proportion of the α,α-dialkylated amino acids, α-aminoisobutyric acid (Aib, U) and isovaline (Iva, J), an acetylated N-terminus and a C-terminal phenylalaninol (Pheol, Fol). The main interest in such peptides stems from their ability to interact with phospholipid bilayers and form voltage-dependent transmembrane channels in planar lipid bilayers. In order to provide insights into the lipid-peptide interaction promoting the voltage gating, the conformational study of TA VII in the presence of perdeuterated sodium dodecyl sulfate (SDS-d25) micelles has been carried out. 1H sequential assignments have been performed with the use of two-dimensional homo- and -heteronuclear nmr techniques including double quantum filtered correlated spectroscopy, homonuclear Hartmann-Hahn, nuclear Overhauser effect spectroscopy, 1H-13C heteronuclear single quantum correlation, and heteronuclear multiple bond correlation. Conformational parameters, such as 3JNHCαH coupling constants, temperature coefficients of amide protons (Δδ/ΔTNH) and quantitative nuclear Overhauser enhancement data, lead to detailed structural information. Ninety-eight three-dimensional structures consistent with the nmr data were generated from 231 interproton distances and six Φ dihedral angle restraints, using restrained molecular dynamics and energy minimization calculations. The average rms deviation between the 98 refined structures and the energy-minimized average structure is 0.59 Å for the backbone atoms. The structure of trichorzianin TA VII associated with SDS micelles, as determined by these methods, is characterized by two right-handed helical segments involving residues 1-8 and 11-19, linked by a β-turn that leads to an angle about 90°-100° between the two helix axes; residues 18 and 19 at the end of the C-terminal helix exhibit multiple conformations. © 1998 John Wiley & Sons, Inc. Biopoly 46: 75-88, 1998
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  • 82
    ISSN: 0006-3525
    Keywords: 9-hydroxyellipticine ; DNA ; CD ; linear dichroism ; resonance light scattering ; intercalation ; drug-drug interactions ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The binding of 9-hydroxyellipticine to calf thymus DNA, poly[d(A-T)]2, and poly-[d(G-C)]2 has been studied in detail by means of CD, linear dichroism, resonance light scattering, and molecular dynamics. The transition moment polarizations of 9-hydroxyelliptiycine were determined in polyvinyl alcohol stretched film. Spectroscopic solution studies of the DNA/drug complex are combined with theoretical CD calculations using the final 50 ps of a series of molecular dynamics simulations as input. The spectroscopic data shows 9-hydroxyellipticine to adopt two main binding modes, one intercalative and the other a stacked binding mode involving the formation of drug oligomers in the DNA major groove. Analysis of the intercalated binding mode in poly[d(A-T)]2 suggests the 9-hydroxyellipticine hydroxyl group lies in the minor groove and hydrogen bonds to water with the pyridine ring protruding into the major groove. The stacked binding mode was examined using resonance light scattering and it was concluded that the drug was forming small oligomer stacks rather than extended aggregates. Reduced linear dichroism measurements suggested a binding geometry that precluded a minor groove binding mode where the plane of the drug makes a 45° angle with the plane of the bases. Thus it was concluded that the drug stacks in the major groove. No obvious differences in the mode of binding of 9-hydroxyellipticine were observed between different DNA sequences; however, the stacked binding mode appeared to be more favorable for calf thymus DNA and poly[d(G-C)]2 than for poly[d(A-T)]2, an observation that could be explained by the slightly greater steric hindrance of the poly[d(A-T)]2 major groove. A strong concentration dependence was observed for the two binding modes where intercalation is favored at very low drug load, with stacking interactions becoming more prominent as the drug concentration is increased. Even at DNA : drug mixing ratios of 70:1 the stacked binding mode was still important for GC-rich DNAs. © 1998 John Wiley & Sons, Inc. Biopoly 46: 127-143, 1998
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  • 83
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    Biopolymers 46 (1998), S. 169-179 
    ISSN: 0006-3525
    Keywords: macromolecular carriers ; drug targeting and delivery ; branched chain synthetic polypeptides ; membrane-synthetic polypeptide interaction ; lipid monolayers/bilayers ; polymer therapeutics ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The surface properties at the air/water interface and the interaction of branched chain polymeric polypeptides with a general formula poly[Lys-(DL-Alam-X1)], where X = Π (AK), Ser (SAK), or Glu (EAK), with phospholipids were investigated. Polylysine derivatives with polycationic (SAK, AK) or amphoteric (EAK) were capable to spread and form stable monomolecular layers. The stability of monolayers at the air/water interface was dependent on the side-chain terminal amino acid residue of polymers and can be described by SAK 〈 AK 〈 EAK order. The area per amino acid residue values calculated from compression isotherms were in the same range as compared to those of linear poly-α-amino acids and proteins. Moreover, these polymers interact with phospholipid monomolecular layers composed of dipalmitoyl phosphatidyl choline (DPPC) or DPPC/PG (PG: phosphatidyl glycerol; 95/5, mol/mol). Data obtained from compression isotherms of phospholipids spread on aqueous polymer solutions at different initial surface pressure indicated that insertion into lipid monolayers for SAK or AK is more pronounced than for EAK. The interaction between branched polypeptides and phospholipid membranes was further investigated using lipid bilayers with DPPC/PG and fluorescent probes located either at the polar surface [1-(4-trimethylammonium-phenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) sodium anilino naphthalene sulfonate (ANS)] or within the hydrophobic core (DPH) of the liposome. Changes in fluorescence intensity and in polarization were observed when TMA-DPH or ANS, but not DPH were used. Comparative data also indicate that all three polymers interact only with the outer surface of the bilayer, but even the most marked penetration of polycationic polypeptide (SAK) did not result in alteration of the ordered state of the alkyl chains in the bilayer. Taken together, data obtained from mono- or bilayer experiments suggest that the interaction between branched polymers and phospholipids are highly dependent on the charge properties (Ser vs Glu) and on the identity (Ser vs Ala) of side-chain terminating amino acids. The binding of polymers to the model membranes could be mainly driven by electrostatic forces, but the significant role of hydrophilic properties in case of SAK cannot be excluded. © 1998 John Wiley & Sons, Inc. Biopoly 46: 169-179, 1998
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  • 84
    ISSN: 0006-3525
    Keywords: Cα,α-dialkylated glycines ; molecular dynamics ; geometry and conformation ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The relationship between the local backbone conformation and bond angles at Cα of symmetrically substituted Cα,α-dialkylated glycines (Cα,α-dimethylglycine or α-aminoisobutyric acid, Aib; Cα,α-diethylglycine, Deg; Cα,α-di-n-propylglycine, Dpg) has been investigated by molecular dynamics (MD) simulation adopting flat bottom harmonic potentials, instead of the usual harmonic restraints, for the Cα bond angles. The MD simulations show that the Cα bond angles are related to the local backbone conformation, irrespectively of the side-chain length of Aib, Deg, and Dpg residues. Moreover, the N-Cα-C′ (τ) angle is the most sensitive conformational parameter and, in the folded form, is always larger and more flexible than in the extended one. © 1998 John Wiley & Sons, Inc. Biopoly 46: 239-244, 1998
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  • 85
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    Biopolymers 46 (1998), S. 319-327 
    ISSN: 0006-3525
    Keywords: methionine ligation ; parathyroid hormones ; biomimetic ligation ; S-methylation ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In biological systems, both proteolysis and aminolysis of amide bonds produce activated intermediates through acyl transfer reactions either inter- or intramolecularly. Protein splicing is an illustrative example that proceeds through a series of catalyzed acyl transfer reactions and culminates at an O- or S-acyl intermediate. This intermediate leads to an uncatalyzed acyl migration to form an amide bond in the spliced product. A ligation method mimicking the uncatalyzed final steps in protein splicing has been developed utilizing the acyl transfer amide-bond feature for the blockwise coupling of unprotected, free peptide segments at methionine (Met). The latent thiol moiety of Met can be exploited using homocysteine at the α-amino terminal position of a free peptide for transthioesterification with another free peptide containing an α-thioester to give an S-acyl intermediate. A subsequent, proximity-driven S- to N-acyl migration of this acyl intermediate spontaneously rearranges to form a homocysteinyl amide bond. S-methylation with excess p-nitrobenezensulfonate yields Met at the ligation site. The methionine ligation is selective and orthogonal, and is usually completed within 4 h when performed at slightly basic pH and under strongly reductive conditions. No side reactions due to acylation were observed with any other α-amines of both peptide segments as seen in the synthesis of parathyroid hormone peptides. Furthermore, cyclic peptide can also be obtained through the same strategy by placing both homocysteine at the amino terminus and the thioester at the carboxyl terminus in an unprotected peptide precursor. These biomimetic ligation strategies hold promise for engineering novel peptides and proteins. © 1998 John Wiley & Sons, Inc. Biopoly 46: 319-327, 1998
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  • 86
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    Biopolymers 46 (1998), S. 359-373 
    ISSN: 0006-3525
    Keywords: boundary element method ; DNA electrophoresis ; electrophoretic mobility of DNA ; free solution electrophoretic mobility of DNA ; ion relaxation, DNA electrophoresis ; modeling electrophoresis of polyions ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Boundary element methods are used to model the free solution electrophoretic mobility of short DNA fragments. The Stern surfaces of the DNA fragments are modeled as plated cylinders that reproduce translational and rotational diffusion constants. The solvent-accessible and ion-accessible surfaces are taken to be coincident with the Stern surface. The mobilities are computed by solving simultaneously the coupled Navier-Stokes, Poisson, and ion-transport equations. The equilibrium electrostatics are treated at the level of the full Poisson-Boltzmann equation and ion relaxation is included. For polyions as highly charged as short DNA fragments, ion relaxation is substantial. At .11 M KCl, the simulated mobilities of a 20 base pair DNA fragment are in excellent agreement with experiment. At .04 M Tris acetate, pH = 8.0, the simulated mobilities are about 10-15% higher than experimental values and this discrepancy is attributed to the relatively large size of the Tris counterion. The length dependence of the mobility at .11 M KCl is also investigated. Earlier mobility studies on lysozyme are reexamined in view of the present findings. In addition to electrophoretic mobilities, the effective polyion charge measured in steady state electrophoresis and its relationship to the preferential interaction parameter γgG is briefly considered. © 1998 John Wiley & Sons, Inc. Biopoly 46: 359-373, 1998
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  • 87
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    Biopolymers 45 (1998), S. 341-346 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract.
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  • 88
    ISSN: 0006-3525
    Keywords: diffusional encounter ; Brownian dynamics ; average Boltzmann factor ; acetylcholinesterase ; Poisson-Boltzmann ; electrostatics ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The utility of the average Boltzmann factor around the active site of an enzyme as the predictor of the electrostatic enhancement of the substrate binding rate is tested on a set of data on wild-type acetylcholinesterase and 18 charge mutants recently obtained by Brownian dynamics simulations. A good correlation between the average Boltzmann factors and the substrate binding rate constants is found. The effects of single charge mutations on both the Boltzmann factor and the substrate binding rate constant are modest, i.e., 〈5 fold increase or decrease. This is consistent with the experimental results of Shafferman et al. but does not support their suggestion that the overall rate of the catalytic reaction is not limited by the diffusional encounter of acetylcholinesterase and its substrate. © 1998 John Wiley & Sons, Inc. Biopoly 45: 355-360, 1998
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  • 89
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    Biopolymers 45 (1998), S. 469-478 
    ISSN: 0006-3525
    Keywords: molecular dynamics ; hydrated proteins ; crystal structures ; density distributions ; globular proteins ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Using molecular dynamics simulations of fully hydrated proteins and analysis of crystal structures contained in the Protein Data Bank, we develop a transferable set of perpendicular radial distribution functions for water molecules around globular proteins. These universal functions may be used to reconstruct the unique three-dimensional solvent density distribution around every individual protein with a modest error. We discuss potential applications of this solvent treatment in protein x-ray crystallographic refinements and in theoretical modeling. We also present a fast, grid-based algorithm for construction of the perpendicular solvent density distributions. © 1998 John Wiley & Sons, Inc. Biopoly 45: 469-478, 1998
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  • 90
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    Biopolymers 47 (1998), S. 23-29 
    ISSN: 0006-3525
    Keywords: independently folded polypeptide motifs ; miniproteins ; natural target domains ; BBA motif ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In this paper we present a redesign strategy for the development of uniquely folded polypeptide motifs of less than 40 residues. These mini proteins are based on natural target domains, including the zinc finger domains (BBA motif) Nomenclature corresponds to the defined elements of secondary structure, beginning at the N-terminus of the peptide. Roman lettering refers to a specific motif while Greek characters correspond to the elements of secondary structure within that motif. and the disulfide-rich snake and scorpion toxins (BBB motif). These motifs are designed to act as the molecular framework for the construction of novel functional polypeptides. We will explore the structural determinants of the folded BBA motif, inspired by the zinc finger peptides, in relation to the redesign process. © 1998 John Wiley & Sons, Inc. Biopoly 47: 23-29, 1998
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  • 91
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    Biopolymers 47 (1998), S. 75-81 
    ISSN: 0006-3525
    Keywords: ion channel ; synthetic peptide ; de novo design ; template-assembled synthetic proteins ; supramolecular assembly ; membrane protein ; planer lipid bilayers ; amphiphilic peptide ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: To create ion channel function by synthetic peptides is a challenge in the de novo design of artificial membrane proteins. Amphiphilic α-helical motifs of ∼ 20 amino acid residues to span lipid bilayers are most often used for the creation of peptide ion channels. Template molecules to tether helical peptides have been employed to obtain more organized pore structures. Approaches to form molecular assembly of peptides in the membranes by hydrogen bonding have been also investigated. We have developed approaches to assemble helices with individual amino acid sequences to construct artificial helical proteins. Using one of these approaches, four helices corresponding to the voltage sensor segments (S4 in repeat I-IV) of the sodium channel were assembled on a peptide template to give a protein having ion channel activity with rectification. © 1998 John Wiley & Sons, Inc. Biopoly 47: 75-81, 1998
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  • 92
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    Biopolymers 47 (1998), S. 127-142 
    ISSN: 0006-3525
    Keywords: collagen mimetics ; triple helix ; peptoid ; template ; biophysics ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Collagen peptidomimetics have been synthesized as an alternative to natural collagen. The incorporation of unnatural residues such as peptoids in the collagen sequences can demonstrate potent and specific biological activity and enhance the biostability against enzymatic degradation. Furthermore, the use of achiral peptoids simplifies synthetic strategies by reducing racemization problems. The peptoid residue N-isobutylglycine (Nleu) has been successfully incorporated into a series of collagen mimetics composed of Gly-Pro-Nleu, Gly-Nleu-Pro, and Gly-Nleu-Nleu. The discovery of template-assembled collagen mimetics and metal binding ability has laid the foundation for new opportunities in the design of novel collagen mimetic complexes. This review summarizes the synthesis and integrated biophysical analyses of the structures of these collagen mimetics. Solid phase segment condensation techniques have been utilized for the synthesis of the single chain and template-assembled analogues. The characterization of the collagen-like structures has been established by temperature-dependent optical rotation measurements, CD, NMR spectroscopy, and molecular modelling simulations. © 1998 John Wiley & Sons, Inc. Biopoly 47: 127-142, 1998
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  • 93
    ISSN: 0006-3525
    Keywords: non-natural amino acid ; peptide ; squarylium dye ; thin film ; poly(3-methylthiophene) ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We designed a polypeptide that behaves as a photodevice by using a non-natural amino acid with replacement of an α-hydrogen by a squarylium dye and succeeded in syntheses of the non-natural amino acid derivative containing a squarylium and its peptide with trialanine Ala-Ala-Ala. Strong dye-dye interactions were confirmed by absorption and CD spectra for the peptide in 2,2,2-trifluoroethanol solution and in water suspension. The non-natural amino acid derivative could be deposited onto a PMeT/Au electrode by the micelle disruption method. © 1998 John Wiley & Sons, Inc. Biopoly 47: 179-183, 1998
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  • 94
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    Biopolymers 47 (1998), S. 263-263 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract.
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  • 95
    ISSN: 0006-3525
    Keywords: electrostatically driven Monte Carlo method ; cluster analysis ; global energy minimum ; perturbed conformations ; conformational space ; lowest energy conformations ; polypeptide chain ; melittin, membrane-bound portion ; Empirical Conformational Energy Program for Peptides 3 ; annealing methods ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electrostatically driven Monte Carlo (EDMC) method has been greatly improved by adding a series of new features, including a procedure for cluster analysis of the accepted conformations. This information is used to guide the search for the global energy minimum. Alternative procedures for generating perturbed conformations to sample the conformational space were also included. These procedures enhance the efficiency of the method by generating a larger number of low-energy conformations.The improved EDMC method has been used to explore the conformational space of a 20-residue polypeptide chain whose sequence corresponds to the membrane-bound portion of melittin. The ECEPP/3 (Empirical Conformational Energy Program for Peptides) algorithm was used to describe the conformational energy of the chain. After an exhaustive search involving 14 independent runs, the lowest energy conformation (LEC) (-91.0 kcal/mol) of the entire study was encountered in four of the runs, while conformations higher in energy by no more than 1.8 kcal/mol were found in the remaining runs with the exception of one of them (run 8). The LEC is identical to the conformation found recently by J. Lee, H.A. Scheraga, and S. Rackovsky [(1998) “Conformational Analysis of the 20-Residue Membrane-Bound Portion of Melittin by Conformational Space Annealing,” Biopolymers, Vol. 46, pp. 103-115] as the lowest energy conformation obtained in their study using the conformational space annealing method. These results suggest that this conformation corresponds to the global energy minimum of the ECEPP/3 potential function for this specific sequence; it also appears to be the conformation of lowest free energy. © 1998 John Wiley & Sons, Inc. Biopoly 46: 117-126, 1998
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  • 96
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    Biopolymers 46 (1998), S. 195-200 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract.
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  • 97
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    Biopolymers 46 (1998), S. 201-214 
    ISSN: 0006-3525
    Keywords: band broadening ; dispersion ; DNA ; gels ; electrophoresis ; fluorescence recovery ; photobleaching ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We determined quantitatively the band broadening effect during gel electrophoresis by measuring the longitudinal dispersion coefficient Dx, with a fluorescence recovery after photobleaching setup, coupled to an electrophoretic cell. We carried out measurements as a function of the electric field, the average pore size, and the molecular length of DNA fragments. Our results are in good agreement with the predictions of the biased reptation model with fluctuations described by T. A. Duke et al. [(1992) Physics Review Letters, vol. 69, pp. 3260-3263]. This agreement is observed on single-stranded DNA [persistence length ≅ 4 nm; B. Tinland et al. (1997) Macromolecules, vol. 30, pp. 5763-5765] in polyacrylamide gels and on double-stranded DNA (persistence length ≅ 50 nm) in agarose gels, two systems where the ratio between the average pore size and the Kuhn length is larger than 1. © 1998 John Wiley & Sons, Inc. Biopoly 46: 201-214, 1998
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  • 98
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    Biopolymers 46 (1998), S. 403-415 
    ISSN: 0006-3525
    Keywords: molecular dynamics ; DNA curvature ; DNA flexibility ; TATA box functionality ; TATA box binding protein (TBP) ; TBP recognition ; TBP binding ; TBP transcriptional activation ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Four 1.5 ns molecular dynamics (MD) simulations were performed on the d(GCTATAAAAGGG) · d(CCCTTTTATAGC) double helix dodecamer bearing the Adenovirus major late promoter TATA element and three iso-composition mutants for which physical and biochemical data are available from the same laboratory. Three of these DNA sequences experimentally induce tight binding with the TATA box binding protein (TBP) and induce high transcription rates; the other DNA sequence induces much lower TBP binding and transcription. The x-ray crystal structures have previously shown that the duplex DNA in DNA-TBP complexes are highly bent. We performed and analyzed MD simulations for these four DNAs, whose experimental structures are not available, in order to address the issue of whether inherent DNA structure and flexibility play a role in establishing these observed preferences. A comparison of the experimental and simulated results demonstrated that DNA duplex sequence-dependent curvature and flexibility play a significant role in TBP recognition, binding, and transcriptional activation. © 1998 John Wiley & Sons, Inc. Biopoly 46: 403-415, 1998
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  • 99
    ISSN: 0006-3525
    Keywords: vibrational CD ; solution conformation ; alanine oligopeptides ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The solution conformation of a number of small, linear alanine oligomers was investigated via ir (or vibrational) CD (VCD). We find that these oligopeptides assume distinct solution conformations that depend primarily on chain lengths, and to a lesser degree on temperature, ionic strength, and pH. As expected, the longer chain oligomers exhibit more distinct VCD features and, presumably, more stable solution structures. At the level of the hexamer, however, aggregation of the peptide occurs. The fast time scale of VCD allows solution structures to be detected that may not be observable using slower techniques such as various forms of nmr spectroscopy. The VCD results reported here confirm that it is generally possible to obtain conformational information for small, linear homo- and heterooligopeptides via VCD spectroscopy. In this respect, the sensitivity of VCD is similar to that of electronic CD. Furthermore, the temperature dependence of the VCD results indicate that at elevated temperatures, the increasing number of conformational states results in a loss of discernible conformers, and consequently, a broadening and weakening of the VCD features. © 1998 John Wiley & Sons, Inc. Biopoly 46: 455-463, 1998
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  • 100
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    Biopolymers 47 (1998), S. 5-22 
    ISSN: 0006-3525
    Keywords: hemoproteins ; model systems ; miniaturized proteins ; mimochromes ; helix structures ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The present paper highlights and reviews current research in the field of hemoprotein models. Hemoproteins have been extensively studied in order to understand structure-function relationships, and to design new molecules with desired functions. A wide number of synthetic analogues have been developed, using quite different approaches. They differ in molecular structures, ranging from simple meso-substituted tetraaryl-metalloporphyrins and peptide-porphyrin conjugates.In this paper we summarize the state of the art on peptide based hemoprotein models. We also report here the approach used by us to develop a new class of molecules, named mimochromes. They can be regarded as miniaturized hemoproteins, because mimochromes are low molecular weight compounds with some structural and functional properties common to those of the parent high molecular weight protein. The basic structure of mimochromes is a deuteroporphyrin ring covalently linked to two helical peptide chains. Two molecules of this series have been fully characterized. All the information derived from their structural analysis has been applied to the design of new analogues with additional functions. © 1998 John Wiley & Sons, Inc. Biopoly 47: 5-22, 1998
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
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