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  • United States  (1,843)
  • Mutation  (1,229)
  • American Association for the Advancement of Science (AAAS)  (3,011)
  • Springer  (49)
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  • 2020-2024
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  • 1995-1999  (1,347)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Computers and the humanities 30 (1996), S. 381-392 
    ISSN: 1572-8412
    Keywords: comparative demographic history ; census ; data set integration ; ICAPUMS ; IPUMS ; coding schemes ; Canada ; United States
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Media Resources and Communication Sciences, Journalism
    Notes: Abstract The comparative use of census data is a useful way to study social characteristics across national boundaries. However, truly comparative demographic history is not possible without fully integrating separate census data, uniting multiple data files with a common set of comparably coded variables. This paper describes the integration of the 1871 Canadian census public use sample with similar samples of the 1850 and 1880 American censuses to form the Integrated Canadian-American Public Use Microdata Series (ICAPUMS). These data sets lent themselves well to integration because of their strong similarities in sampling design, data collection and data organization. Consistency in the availability and treatment of variables also eased integration of the samples, although the harmonization of occupation variables presented significant challenges. The ICAPUMS features a general household relationship variable which allows us to examine household structure across the two countries and three years. The paper concludes by proposing some general principles of census data set integration. This integrated data set is now available to researchers on the website of the University of Minnesota Historical Census Projects (www.hist.umn.edu/~ipums).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0789
    Keywords: Mungbean ; Vigna radiata ; Nitrogen fixation ; Hydrogen uptake ; Mutation ; Nitrosoguanidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract H2 uptake activity was well distributed in Rhizobium sp. strains isolated from nodules of mung-bean (Vigna radiata L.). Two effective strains, RMP1 und RMP2, exhibiting significantly higher H2 uptake activity were subjected to mutagenesis with nitrosoguanidine. The respective mutation frequencies were 0.18 and 0.19%. Three Hup- mutants each of RMP1 und RMP2 were compared with the wild-type parent strains under pot culture experiments to evaluate the significance of the H2 uptake system in biological N2 fixation. Nodulation capabilities, plant growth characteristics, and the chlorophyll content of the leaves were significantly reduced in the plants treated with Hup- mutants. Nitrogenase activity in Hup- nodules was reduced by 8–41%. Similarly, N accumulation was also reduced singificantly.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular evolution 41 (1995), S. 732-740 
    ISSN: 1432-1432
    Keywords: Mutation ; Nearest ; neighbor effects ; DNA structure ; Brassica incompatibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A highly variable family of related DNA sequences was examined in order to determine the effect of local sequence environment on substitution mutation; 29 sequences from the Brassica self-incompatibility gene family, which possess a high level of nonsynonymous mutations, were aligned and grouped according to their similarity and function. The level and distribution of substitution mutations were calculated. A nonrandom distribution of sequence variation was observed along the sequences. The effect of neighbor biases and structural and thermodynamic measures were then compared in the absence of strong codon conservation. Biases were observed in the rates of substitution of the same base pair in different local sequence environments. The effect of the 5′ neighbor was such that nucleotide A or C was associated with more mutations than G or T. There were significant interactions of certain dinucleotides with the frequency of mutation. Sequence-dependent measures of helical stability, intrinsic curvature, components of curvature, and stacking interactions were calculated for each sequence. Decreased helical stability was found to be associated with increased mutation. The compound measure of curvature, calculated according to the “wedge” model, showed little association with mutation. However, the components of increased wedge angle and decreased twist both showed an association with increased mutation. A small effect of A-type DNA stacking was found to be associated with mutated bases.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of law and economics 4 (1997), S. 147-232 
    ISSN: 1572-9990
    Keywords: Methodology ; history of social science ; economists ; political economy ; history ; historical school ; Germany ; England ; United States ; historicism ; economics ; philosophy ; Wolff
    Source: Springer Online Journal Archives 1860-2000
    Topics: Law , Economics
    Notes: Abstract This paper explores the place of Christian Wolff in the history of social science in English. The "Introduction" places Wolff in the context of the pre-history of modern social science. Samples are given of the great range of subjects on which he wrote. The importance of the German context is stressed. The second part is devoted to a sample of what the literature contains by and about Wolff. It emphasizes philosophy and science. Part three is a survey of works in the history of the social sciences that mention Wolff. He has a substantial place in political science and psychology, a much smaller place in economics and history, virtually none in anthropology, geography, and sociology. In the applied social sciences, he is found in the history of education. Possible reasons are given. Part four is devoted to the relationships of philosophy and philosophers in the pre-history of the social sciences. They were important in several different ways because they both shaped and reflected how many people thought about science and social problems. The “Summary and Conclusion” describes the present status. His contributions are summarized. He was a pivotal figure in the making of the German conception of social science. This is a preliminary study emphasizing the issues and problems that a more detailed examination would require. Several conventional judgments are challenged and possibilities for further research suggested.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of the history of biology 32 (1999), S. 163-195 
    ISSN: 1573-0387
    Keywords: cytogenetics ; diagrams ; genetics ; illustrations ; McClintock ; models ; molecular biology ; photographs ; twentieth-century ; United States
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , History
    Notes: Abstract Barbara McClintock won the Nobel Prize in 1983 for her discovery of mobile genetic elements. Her Nobel work began in 1944, and by 1950 McClintock began presenting her work on “controlling elements.” McClintock performed her studies through the use of controlled breeding experiments with known mutant stocks, and read the action of controlling elements (transposons) in visible patterns of pigment and starch distribution. She taught close colleagues to “read” the patterns in her maize kernels, “seeing” pigment and starch genes turning on and off. McClintock illustrated her talks and papers on controlling elements or transposons with photographs of the spotted and streaked maize kernels which were both her evidence and the key to her explanations. Transposon action could be read in the patterns by the initiated, but those without step by step instruction by McClintock or experience in maize often found her presentations confusing. The photographs she displayed became both McClintock's means of communication, and a barrier to successful presentation of her results. The photographs also had a second and more subtle effect. As images of patterns arrived at through growth and development of the kernel, they highlight what McClintock believed to be the developmental consequences of transposition, which in McClintock's view was her central contribution, over the mechanism of transposition, for which she was eventually recognized by others. Scientific activities are extremely visual, both at the sites of investigation and in communication through drawings, photographs, and movies. Those visual messages deserve greater scrutiny by historians of science.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of biomedical science 3 (1996), S. 143-158 
    ISSN: 1423-0127
    Keywords: Transforming growth factor-β ; Tumorigenesis ; Mutation ; Tumor suppressor gene ; Receptor ; Microsatellite instability ; Transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Transforming growth factor-β (TGF-β) plays a pivotal role in numerous vital cellular activities, most significantly the regulation of cellular proliferation and differentiation and synthesis of extracellular matrix components. Its ubiquitous presence in different tissues and strict conservation of nucleotide sequence down through the most primitive vertebrate organisms underscore the essential nature of this family of molecules. The effects of TGF-β are mediated by a family of dedicated receptors, the TGF-β types I, II, and III receptors. It is now known that a wide variety of human pathology can be caused by aberrant expression and function of these receptors or their cognate ligands. The coding sequence of the human type II receptor appears to render it uniquely susceptible to DNA replication errors in the course of normal cell division. There are now substantial data suggesting that TGF-β type II receptor should be considered a tumor suppressor gene. High levels of mutation in the TGF-β type II receptor gene have been observed in a wide variety of primarily epithelial malignancies, including colon, gastric, and hepatic cancer. It appears likely that mutation of the TGF-β type II receptor gene represents a very critical step in the pathway of carcinogenesis.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of biomedical science 4 (1997), S. 319-326 
    ISSN: 1423-0127
    Keywords: Oxidative damage ; Reactive oxygen species ; Mitochondria ; Mitochondrial DNA ; Mutation ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mitochondria are the major intracellular source and target sites of reactive oxygen species (ROS) that are continually generated as by-products of aerobic metabolism in animal and human cells. It has been demonstrated that mitochondrial respiratory function declines with age in various human tissues and that a defective respiratory chain results in enhanced production of ROS and free radicals in mitochondria. On the other hand, accumulating evidence now indicates that lipid peroxidation, protein modification and mitochondrial DNA (mtDNA) muutation are concurrently increased during aging. On the basis of these observations and the fact that the rate of cellular production of superoxide anions and hydrogen peroxide increases with age, it has recently been postulated that oxidative stress is a major contributory factor in the aging process. A causal relationship between oxidative modification and mutation of mtDNA, mitochondrial dysfunction and aging has emerged, although some details have remained unsolved. In this article, the role of mitochondria in the human aging process is reviewed on the basis of recent findings gathered from our and other laboratories.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1211
    Keywords: Key words Llama ; splice ; CH1 ; Antibody ; Mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1211
    Keywords: Key words HLA complex ; Immotile cilia syndrome ; Mutation ; Kinesin multigene family ; Human Chromosome 6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The kinesin-related protein (HSET) gene belongs to the kinesin superfamily, the members of which are involved in cellular transport processes. The HSET gene product was previously characterized by partial cDNA sequencing. The gene is located on the short arm of human Chromosome 6 (6p21.3), at the centromeric end of the major histocompatibility complex. Here, we report the genomic structure of the complete HSET gene together with its flanking loci. Sequence analysis of the 40 kilobase (kb) cosmid clone containing the HSET gene also revealed the presence of several new genes not related to the kinesin superfamily. These include a 60S ribosomal protein L35A-like pseudogene (rPL35A-like) on the telomeric side and a polycomb-like gene (PHF1), a copper tolerance-like gene (CUTA1) and the 5' part of the synaptic ras-GTPase-activating protein (SynGAP) gene centromeric of HSET. In addition, a complete 60S ribosomal protein L12-like (rPL12L) gene in intron 3 of the HSET gene was identified which appears to have an open reading frame. The possible involvement of the HSET gene and a β-tubulin gene (TUBB) in the pathogenesis of immotile cilia syndrome (ICS) was studied by screening two unrelated ICS families with microtubular defects and suspected HLA linkage for mutations within the HSET gene and the TUBB gene. Four single base substitutions were detected in the HSET gene, and none in the TUBB gene. On the basis of these data, a role of the HSET and TUBB products in the pathogenesis of ICS in the two families is unlikely.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Sexual plant reproduction 10 (1997), S. 300-304 
    ISSN: 1432-2145
    Keywords: Key words Embryo sac ; Structural changes ; Mutation ; Nicotiana tabacum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The semisterile tobacco plant BG-141.4 was produced using both irradiation with X-rays and anther culture. The embryological investigation of the progeny of this plant following selfing (R1) revealed disturbances in the structure of the mature embryo sacs (ESs). The major abnormality was a decrease in cell number in the ESs. Other abnormalities included disturbances in the distribution of nuclei and in cell differentiation. The overall frequency of abnormal ESs in individual plants investigated varied from 8% to 83%, while the frequency of ESs with a reduced number of cells varied from 5% to 72%. Since the examination of three subsequent generations - R2, R3 and R4 - showed similar results, it is concluded that a mutation has been induced. Its main phenotypic manifestation is most likely related to its lacking one or two nuclear division(s) during the coenocytic stage of megagametogenesis. The penetrance of the mutation varies widely.
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