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1

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Bcl-2 family member Bcl-G is not a proapoptotic protein (2012)

M Giam; T Okamoto; J D Mintern; A Strasser; P Bouillet

Springer Nature

In: Cell Death & Disease

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Publication Date: 2012-10-12

Description: Bcl-2 family member Bcl-G is not a proapoptotic protein Cell Death and Disease 3, e404 (October 2012). doi:10.1038/cddis.2012.130 Authors: M Giam, T Okamoto, J D Mintern, A Strasser & P Bouillet

Keywords: apoptosisBcl-GBcl-2 family

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

Published by Springer Nature

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Detection of Bcl-2 family member Bcl-G in mouse tissues using new monoclonal antibodies (2012)

M Giam; J D Mintern; G J P Rautureau; M G Hinds; A Strasser; P Bouillet

Springer Nature

In: Cell Death & Disease

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Publication Date: 2012-08-24

Description: Detection of Bcl-2 family member Bcl-G in mouse tissues using new monoclonal antibodies Cell Death and Disease 3, e378 (August 2012). doi:10.1038/cddis.2012.117 Authors: M Giam, J D Mintern, G J P Rautureau, M G Hinds, A Strasser & P Bouillet

Keywords: apoptosisBcl-GBcl-2 family

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

Published by Springer Nature

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Energy landscape of knotted protein folding [Biophysics and Computational Biology] (2012)

Sulkowska, J. I., Noel, J. K., Onuchic, J. N.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-10-31

Description: Recent experiments have conclusively shown that proteins are able to fold from an unknotted, denatured polypeptide to the knotted, native state without the aid of chaperones. These experiments are consistent with a growing body of theoretical work showing that a funneled, minimally frustrated energy landscape is sufficient to fold small...

Keywords: Chemical Physics of Protein Folding Special Feature

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Effects of chemical chaperones on {alpha}-synuclein [Biophysics and Computational Biology] (2012)

Ferreon, A. C. M., Moosa, M. M., Gambin, Y., Deniz, A. A.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-10-31

Description: Protein structure and function depend on a close interplay between intrinsic folding energy landscapes and the chemistry of the protein environment. Osmolytes are small-molecule compounds that can act as chemical chaperones by altering the environment in a cellular context. Despite their importance, detailed studies on the role of these chemical...

Keywords: Chemical Physics of Protein Folding Special Feature

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Mechanical unfolding pathway of src SH3 [Biophysics and Computational Biology] (2012)

Jagannathan, B., Elms, P. J., Bustamante, C., Marqusee, S.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-10-31

Description: Many biological processes generate force, and proteins have evolved to resist and respond to tension along different force axes. Single-molecule force spectroscopy allows for molecular insight into the behavior of proteins under force and the mechanism of protein folding in general. Here, we have used src SH3 to investigate the...

Keywords: Chemical Physics of Protein Folding Special Feature

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Villin kinetics and thermodynamics from simulation [Biophysics and Computational Biology] (2012)

Piana, S., Lindorff-Larsen, K., Shaw, D. E.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-10-31

Description: Advances in simulation techniques and computing hardware have created a substantial overlap between the timescales accessible to atomic-level simulations and those on which the fastest-folding proteins fold. Here we demonstrate, using simulations of four variants of the human villin headpiece, how simulations of spontaneous folding and unfolding can provide direct...

Keywords: Chemical Physics of Protein Folding Special Feature

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Folding GFP [Biophysics and Computational Biology] (2012)

Reddy, G., Liu, Z., Thirumalai, D.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-10-31

Description: We use molecular simulations using a coarse-grained model to map the folding landscape of Green Fluorescent Protein (GFP), which is extensively used as a marker in cell biology and biotechnology. Thermal and Guanidinium chloride (GdmCl) induced unfolding of a variant of GFP, without the chromophore, occurs in an apparent two-state...

Keywords: Chemical Physics of Protein Folding Special Feature

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

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Folding intermediate initiates misfolding pathway [Biophysics and Computational Biology] (2012)

Korzhnev, D. M., Religa, T. L., Kay, L. E.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-10-31

Description: Studies of protein folding and the intermediates that are formed along the folding pathway provide valuable insights into the process by which an unfolded ensemble forms a functional native conformation. However, because intermediates on folding pathways can serve as initiation points of aggregation (implicated in a number of diseases), their...

Keywords: Chemical Physics of Protein Folding Special Feature

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Mass independent isotope effects [Physical Sciences] (2013)

Thiemens, M. H.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2013-10-30

Description: Stable isotope ratio variations are regulated by physical and chemical laws. These rules depend on a relation with mass differences between isotopes. New classes of isotope variation effects that deviate from mass dependent laws, termed mass independent isotope effects, were discovered in 1983 and have a wide range of applications...

Keywords: Chemistry and Applications in Nature of Mass Independent Isotope Effects Special Feature

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

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Marine sulfur cycle constraints on S MIF [Earth, Atmospheric, and Planetary Sciences] (2013)

Halevy, I.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2013-10-30

Description: Mass-independent fractionation of sulfur isotopes (S MIF) in Archean and Paleoproterozoic rocks provides strong evidence for an anoxic atmosphere before ∼2,400 Ma. However, the origin of this isotopic anomaly remains unclear, as does the identity of the molecules that carried it from the atmosphere to Earth’s surface. Irrespective of the...

Keywords: Chemistry and Applications in Nature of Mass Independent Isotope Effects Special Feature

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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