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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Computer vision. ; Radiology. ; Biotechnology. ; Computer Vision. ; Radiology.
    Description / Table of Contents: Introduction -- Preliminaries -- Fuzzy spatial objects (fuzzy geometry and topology, set theoretic operations) -- Mathematical morphology -- Distances and similarities between fuzzy sets -- Machine learning in image processing and understanding -- Fusion -- Spatial relations -- Structural representations.
    Abstract: This book provides a thorough overview of recent methods using higher level information (object or scene level) for advanced tasks such as image understanding along with their applications to medical images. Advanced methods for fuzzy image processing and understanding are presented, including fuzzy spatial objects, geometry and topology, mathematical morphology, machine learning, verbal descriptions of image content, fusion, spatial relations, and structural representations. For each methodological aspect covered, illustrations from the medical imaging domain are provided. This is an ideal book for graduate students and researchers in the field of medical image processing. This book also: Enriches reader understanding of the latest fuzzy sets methods using higher level information (object or scene level) for advanced tasks, such as image understanding Shares many insights into fuzzy spatial objects, including fuzzy geometry and topology as well as set theoretical operations Covers in detail machine learning in image processing and understanding, with special focus on clustering, classification, and basic and advanced fuzzy methods .
    Type of Medium: Online Resource
    Pages: XIII, 302 p. 97 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031194252
    DDC: 660.6
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Forestry. ; Geography. ; Biotic communities. ; Forestry. ; Regional Geography. ; Ecosystems.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Forest Land Use/Cover Change -- Chapter 3. Forest Classifications and Working Circles -- Chapter 4. National Parks, Wildlife Sanctuaries, and Conservation Reserves -- Chapter 5. Forest Diversity and Distribution -- Chapter 6. Forest Stocks and Products -- Chapter 7. Environmental Index -- Chapter 8. Ecosystem Goods and Services -- Chapter 9. Drivers of Forest Degradation and Conservation Measures -- Chapter 10. Climate Change and Forests -- Chapter 11. Cultural and Socio-Economic Significance of Forests -- Chapter 12. Sustainable Forest Management -- Chapter 13. Conclusions.
    Abstract: This volume presents a comprehensive description of forests of the Uttarakhand Himalaya. It looks into the major drivers of forest depletion and suggests paths toward sustainable forest management. The book comprises thirteen chapters, which together describe forest land use/cover change; forest classification and working circles; national parks, wildlife sanctuaries, and conservation reserves; forest diversity and distribution; forest stocks and products; ecosystem goods and services; environmental index; drivers of forest degradation and conservation; climate change and forests; cultural and economic significance of forests, and sustainable forest management. The text is richly complemented by nearly seventy photographs and figures.
    Type of Medium: Online Resource
    Pages: XXX, 172 p. 71 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031219368
    DDC: 634.9
    Language: English
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  • 3
    Keywords: Regenerative medicine. ; Stem cells. ; Nervous system Regeneration. ; Biomaterials. ; Cells. ; Regenerative Medicine and Tissue Engineering. ; Stem Cell Biology. ; Regeneration and Repair in the Nervous System. ; Biomaterials-Cells.
    Description / Table of Contents: Chapter 1. Regeneration and tissue microenvironment -- Chapter 2. Non stem cell mediated tissue regeneration and repair -- Chapter 3. Immunological Perspectives Involved in Tissue Engineering -- Chapter 4. Advances in Medical Imaging for Wound Repair and Regenerative Medicine -- Chapter 5. Role of Biosensors in Regenerative Therapeutics: Past, Present & Future Prospects -- Chapter 6. Acute and Chronic Wound Management: Assessment, Therapy and Monitoring Strategies -- Chapter 7. Stem cells and therapies in cardiac regeneration -- Chapter 8. Hydrogel-based Tissue-mimics for Vascular Regeneration and Tumor Angiogenesis -- Chapter 9. Advances in 3D Printing Technology for Tissue Engineering -- Chapter 10. Adult Neurogenesis: A Potential Target for Regenerative Medicine -- Chapter 11. Regenerative approaches in the nervous system -- Chapter 12. Prenatal interventions for the treatment of congenital disorders -- Chapter 13. Understanding LncRNAs in biomaterials development for osteointegration -- Chapter 14. Current approaches in vertical bone augmentation and large bone deficiencies in the oro-facial region -- Chapter 15. In-vitro and in-vivo tracking of cell-biomaterial interaction to monitor the process of bone regeneration -- Chapter 16. The Prospects of RNAs and Common Significant Pathways in Cancer Therapy and Regenerative Medicine.
    Abstract: This book focuses on the recent innovations and therapeutic potentials of regenerative medicine and discusses the applications of stem cells, biomaterials, and tissue engineering in regenerative medicine. The book covers essential aspects of regenerative medicine, including tissue microenvironment, immunological perspectives, stem, and non-stem cell-mediated approaches, imaging techniques, biomarkers, and 3D printing technology. It also reviews the applications of biosensing technologies in regenerative medicine, including biomanufacturing, organ-on-a-chip technologies, and as indicators of therapeutic efficacy. Further, it focuses on the regenerative medicine approaches for diseases of the central nervous system. It also provides the therapeutic potential of regenerative medicine to improve soft tissue and wound healing, cardiovascular, neural, bone, and orofacial regeneration.
    Type of Medium: Online Resource
    Pages: XV, 390 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811960086
    DDC: 612.028
    Language: English
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  • 4
    Keywords: Biodiversity. ; Biotic communities. ; Conservation biology. ; Ecology . ; Vertebrates. ; Invertebrates. ; Biodiversity. ; Ecosystems. ; Conservation Biology. ; Vertebrate Zoology. ; Invertebrate Zoology.
    Description / Table of Contents: 1.1 General Introduction Principal -- 2. Zoloogical Groups -- 2.1 Arachnids -- 2.2 Insects: Migrants, endemics, and old to new pests -- 2.3 Freshwater decapod crustaceans: the challenges of documenting and preserving a very diverse fauna -- 2.4 Mexican molluscs: In the process of a 'silent extinction' -- 2.5 Amphibians and reptiles -- 2.6 Anthropocene impacts on the Mexican freshwater fish fauna -- 2.7 Mexican avifaunas of the Anthropocene -- 2.8 Marine birds -- 2.9 Terrestrial mammals -- 2.10 Marine mammals -- 2.11Mexican bats: conservation challenges in the Anthropocene -- 3. Ecosytems -- 3.1 The impact of the growth of urban environments on Mexican fauna -- 3.2 Anchialine fauna of the Yucatan Peninsula -- 3.3 Semi-terrestrial and aquatic invertebrates and fish in mangroves in México -- 3.4 Defaunation of Mexican tropical forests3.5 Mezcal boom and extinction debts in Mexican arid ecosystems -- 3.6 Deep sea life -- 3.7 The importance of agroecosystems for the Mexican fauna -- 3.8 The salamanders of the Mexican cloud forest -- 3.9 Human effects on caves in Mexico -- 3.10 Fauna of lakes and rivers -- 3.11 Coral reef faunal assemblages in the Mexican Caribbean: assessing the cryptic biodiversity -- 4 Processes -- 4.1 Contemporary climate change impacts on Mexican fauna -- 4.2 Invasive alien species of invertebrates and fishes introduced to Mexican freshwater systems -- 4.3 Are marine fisheries sustainable? -- 4.4 Pest dynamics in Mexican forests -- 4.5 Pollination by wild and managed animal vectors -- 4.6 Social participation strategies for the conservation of Mexican fauna -- 4.7 Citizen science for deep ocean biodiversity: a crowdsourcing tool in support of conservation -- 4.8 Legal actions for the conservation of fauna.
    Abstract: This contributed volume presents an analysis of the current conservation status of major faunal groups in Mexico. The chapters describe a prognosis of future challenges, and also explore the expanding threats inherent in the Anthropocene within the context of the unique physical, biological and cultural aspects of the nation. Covering 27 chapters, and written by Mexican and international authors, this book analyzes a wide range of vertebrate and invertebrate animal taxa, their ecosystems and the critical processes related to their present conservation status. This volume is an important reference material for researchers, conservationists and students interested in the biological and ecological processes shaping the Mexican fauna.
    Type of Medium: Online Resource
    Pages: XVII, 597 p. 50 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031172779
    DDC: 333.95
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Water. ; Hydrology. ; Biotic communities. ; Social sciences. ; Humanities. ; Environmental management. ; Freshwater and Marine Ecology. ; Water. ; Ecosystems. ; Humanities and Social Sciences. ; Environmental Management.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Southern Baltic Coastal Systems Analysis: Questions, Conceptions and Red Threads -- Chapter 2. Coastal Ecosystems from a Social-Ecological Perspective -- Part II. Ecological Structures and Functions of the German Baltic Sea Coast -- Chapter 3. The Abiotic Background: Climatic, Hydrological and Geological Conditions of the Southern Baltic -- Chapter 4. Geological and Sedimentary Conditions -- Chapter 5. Environmental Conditions at the Coast: The Terrestrial Ecosystems -- Chapter 6. Environmental Conditions at the Coast: Shoreline Ecosystems -- Chapter 7. Ecosystem and Landscape Functions of the Coast: Recent Research Results -- Chapter 8: Benthic Habitats and Their Inhabitants -- Part III. Ecological Structures and Functions of Coastal Water and Offshore Ecosystems -- Chapter 9. Introducing the Ecological Aspects -- Chapter 10. Baltic Sea Aquatic Ecosystems in a Gradient from Land to Open Sea -- Chapter 11. Comparison of Abiotic Parameters and Dominant Primary Producers Between the Two Main Investigation Areas -- Chapter 12. Short-Term Variability, Long-Term Trends and Seasonal Aspects in the Darß-Zingst Bodden Chain -- Chapter 13. Carbon Fluxes/Food-Webs: Effect of Macrophytes on Food Web Characteristics in Coastal Lagoons -- Chapter 14. Ecological Structure in Benthic Habitats of Offshore Waters -- Chapter 15. Patterns of Bioturbation and Associated Matter Fluxes -- Chapter 16. Seasonal Aspects and Short-Term Variability of the Pelagic Offshore Ecosystems -- Chapter 17. Long-Term Trends of the Offshore Ecosystems -- Chapter 18. Nutrient and Limitation Regimes in Coastal Water Ecosystems -- Part IV. Combining the Aspects: Ecosystem Service Assessment -- Chapter 19. The Human Factor: Coastal Social-Ecological Systems -- Chapter 20. Introduction: The Concept of Ecosystem Service Assessment Applied to Coastal Systems -- Chapter 21. The Missing Links in Ecosystem Service Research -- Chapter 22. Eudaimonic Valuation of Cultural Ecosystem Services -- Chapter 23. Economic Valuation of Cultural Ecosystem Services -- Chapter 24. Spatial Ecosystem Service Assessment Across the Land-Sea-Interface -- Chapter 25. Temporal Changes in Aquatic Ecosystem Services Provision: Approach and Examples -- Chapter 26. Assessing Temporal Changes in Ecosystem Service Provisions: Conceiving Future Pathways -- Part V. Synthesis: Assessment as a Tool for Managing Coastal Ecosystems? -- Chapter 27. Applying the Integrated Approach -- Chapter 28. Mechanisms of Ecosystem Service Production: An Outcome of Ecosystem Functions and Ecological Integrity in Coastal Lagoons -- Chapter 29. Ecosystem Service Assessment in European Coastal and Marine Policies -- Chapter 30. Ecosystem Services and Sustainable Development: The Case for Strong Sustainability -- Chapter 31. Concluding Remarks.
    Abstract: This book gives an overall analysis of the current knowledge status about structures, functions, utilization for German Baltic coast ecosystems. The main focus of this book is on the aquatic area, but land/sea interactions as well as river outfalls are included as well. Characteristic for this book is the inclusion of social science aspects. Approximately one third of its extent will be about the ecosystem services. In this segment the results of the last 6 years are presented in which a comprehensive quantification of the social relevance of ecosystems was carried out covering the entire area of the German Baltic Sea. This part builds directly on the results of scientific investigations and are in relation to social ideals. The assessment will not only be economically and ethically but also the mechanisms that are used for the valorisation of the ecosystem services will be evaluated. Both sub-areas, the classic natural science part as well as the part of social science aspects, deal with the changes caused by increasing anthropogenic influence and social (including demographic) changes. This will be among others in the sense of an exemplary historical outline. The final chapter of the synthesis therefore not only presents a summary of the level of knowledge gained and a deduction of the research needs. It further contains a presentation of the application aspects resulting from the analysis of the social relevance gained from basic scientific research. The book is aimed at scientists (and students) of natural, life and social sciences, analysing functioning and structures of coastal ecosystems with regard to sustainable use and nature protection, including aspects of coastal protection. Besides, it is thought to become a reference for all levels of decision makers and stakeholders in coastal and marine management of the Baltic and North Sea region, providing also a blueprint for system analysis respecting for societal as well as biological aspects world-wide.
    Type of Medium: Online Resource
    Pages: XV, 387 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031136825
    Series Statement: Ecological Studies, Analysis and Synthesis, 246
    DDC: 577.6
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Human physiology. ; Neurology . ; Life sciences. ; Physiology. ; Neuroscience. ; Human Physiology. ; Neurology. ; Life Sciences. ; Animal Physiology. ; Life Sciences.
    Description / Table of Contents: Part I: HISTORY -- Chapter 1: Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek -- Part II: GENERAL ASPECTS OF PRIONS -- Chapter 2: The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein -- Chapter 3: Mammalian Prion Structures -- Chapter 4: Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein Aggregates in the Brain of Asymptomatic Individuals -- Part III: CONVERSION AND STRAIN OF PRIONS -- Chapter 5: Prion Conversion and Deformed Templating -- Chapter 6: Prion Strain Interference -- Chapter 7: Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins -- Chapter 8: Cofactor Involvement in Prion Propagation -- Chapter 9: Prion Protein Conversion and Lipids -- Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS -- Chapter 10: Prions in the Environment -- Chapter 11: Environmentally Acquired Transmissible Spongiform Encephalopathy -- Chapter 12: Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion -- Chapter 13: Species Barriers in Prion Disease -- Part V: MODELLING OF PRIONS -- Chapter 14: Modeling the Cell Biology of Prions -- Chapter 15: Transgenic Mice Modelling in Prion Diseases -- Chapter 16: Stem Cell Models in Prion Research -- Chapter 17: Drosophila Models of Prion Diseases -- Part VI: HUMAN PRION DISEASES AND OTHER PATHOLOGIES -- Chapter 18: Human Sporadic Prion Diseases -- Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker Diseases -- Chapter 20: Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies -- Chapter 21: The Spectrum of Tau Pathology in Human Prion Disease -- Chapter 22: Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease -- Chapter 23: Prion and Cancers -- Chapter 24: Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury -- Part VII: ANIMAL PRION DISEASES -- Chapter 25: Bovine Spongiform Encephalopathy -- Chapter 26: Classical and Atypical Scrapie in Sheep and Goats -- Chapter 27: Research models for studying chronic wasting disease -- Part VIII: YEAST PRIONS -- Chapter 28: Introduction to Yeast and Fungal Prions -- Chapter 29: Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems -- Part IX: DIAGNOSIS AND HUMAN PRION SURVEILLANCE -- Chapter 30: Real-time quaking-induced conversion (QuIC) assays for the detection and diagnosis of human prion diseases -- Chapter 31: Protein Misfolding Cyclic Amplification -- Chapter 32: Skin Misfolded Proteins as Biomarkers for Diagnosis of Prion and Prion-like Diseases -- Chapter 33: Diagnosis of Prion Disease: Conventional Approaches -- Chapter 34: Human Prion Disease Surveillance -- Part X: TREATMENT -- Chapter 35: Overview on Treatment of Prion Diseases and Decontamination of Prions -- Chapter 36: Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases -- Chapter 37: Immunomodulation.
    Abstract: Transmissible spongiform encephalopathies (TSE), now known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains the most authoritative views about the past, present, and future of prions and prion diseases covering fresh perspectives on important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
    Type of Medium: Online Resource
    Pages: XII, 793 p. 81 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031205651
    DDC: 612.8
    Language: English
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  • 7
    Keywords: Zoology. ; Human evolution. ; Anthropology. ; Physical anthropology. ; Animal culture. ; Zoology. ; Evolutionary Anthropology. ; Physical-Biological Anthropology. ; Animal Science.
    Description / Table of Contents: Introduction -- Part 1-Human Influences on Primate Habitats -- Forest Fragmentation -- Primates in Regenerating Forest -- Responses of primates to roads: Dispersal barriers, mortality, and secondary effects -- Hunting by humans -- Primate-dog interactions -- Primate Tourism -- Infectious disease -- Climate change impacts on non-human primates – what have we modelled and what do we do now? -- PART 2: PRIMATES IN HUMAN-DOMINATED LANSCAPES -- Community-based conservation strategies to promote primate conservation in agricultural landscapes -- Translocated primate populations -- Translocated primate populations -- Exploring the human-primate interface -- Planning primate conservation in shared landscapes -- Non-pathogenic influences on primate health and behaviour -- PART 3: PRIMATES IN CAPTIVITY -- Anthropogenic and observer effects on primate behaviour: Perspectives on the continuum of wild-captive behaviour -- The primate pet trade -- Rescue, rehabilitation, and reintroduction.
    Abstract: The field of primatology has expanded substantially in the last twenty years, particularly with regard to studies of primates in human-altered landscapes. This text aims to review the recent literature on anthropogenic (of human origin) influences on non-human primates, bringing an overview of this important area of primatology together for students. Chapters are grouped into three sections, representing the many ways anthropogenic activities affect primate populations. The first section, ‘Human Influences on Primate Habitat’, covers ways in which wild primates are affected by human actions, including forest fragmentation, climate change, and the presence of dogs. Section two, ‘Primates in Human-Dominated Landscapes’, looks at situations where non-human primates and humans share space; this includes primates in urban environments, primate tourism, and primates in agroecosystems. The final section, ‘Primates in Captivity’, looks at primate behaviour and welfare in captive situations, including zoos, the primate pet trade, and in entertainment.
    Type of Medium: Online Resource
    Pages: XIII, 346 p. 36 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031117367
    Series Statement: Developments in Primatology: Progress and Prospects,
    DDC: 590
    Language: English
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  • 8
    Keywords: Immunology. ; Medicine History. ; Medicine Research. ; Biology Research. ; Immunology. ; History of Medicine. ; Biomedical Research.
    Description / Table of Contents: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Z.
    Abstract: Hundreds of eponyms are used within the field of immunology—Petri dish, Crohn’s disease, Bence Jones protein, Kupffer cells, Freund's adjuvant, Ouchterlony immunodiffusion, to name just a few—but most of us don't know much about the individuals who gave their names to these terms. Where were they born and educated, what other accomplishments are they credited with, why has history chosen to remember them, or not? This book presents the first comprehensive collection of immunologic eponyms, and through them tells the story of this fascinating field, from its earliest beginnings to present day. Organized by surname and meticulously cross-referenced and indexed, this book offers historical anecdotes and little-known facts which scientists, clinicians, students, and general readers will find captivating and memorable. A one-of-a-kind introduction to immunology that serves as both a history lesson and current reference on the diseases, treatments, and individuals who have been crucial to this field.
    Type of Medium: Online Resource
    Pages: XXVIII, 405 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031145292
    DDC: 571.96
    Language: English
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  • 9
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biology Technique. ; Food Microbiology. ; Food science. ; Biological Techniques. ; Food Microbiology. ; Food Science.
    Description / Table of Contents: Chapter 1. History and Technology of Chinese Liquor -- Chapter 2. Classification of Chinese Baijiu -- Chapter 3.Baijiu-Making Equipments -- Chapter 4. Process Principles and Engineering of Solid-State Fermentation of Chinese Liquor -- Chapter 5. Solid-state Distillation of Chinese Liquor (Baijiu) -- Chapter 6. History and advance of flavour research of Baijiu -- Chapter 7. Sensory Properties of Baijiu -- Chapter 8. Chemical Components of Chinese Baijiu -- Chapter 9. Microbial Diversities During Chinese Liquor Fermentations -- Chapter 10. Composition and Succession of the Microbiota in Light-Aroma Baijiu Production -- Chapter 11. Diversity and Succession of the Microbiota in Sauce-Aroma Baijiu -- Chapter 12. Composition, Succession and Key Species of Microbiota in Strong-Aroma Baijiu Production -- Chapter 13. Functional Microorganisms Associated with Baijiu Fermentation -- Chapter 14. Microbial interaction in Chinese liquor fermentation -- Chapter 15. Regulation of the microbiota in Chinese liquor fermentation process -- Chapter 16. Challenges and Perspectives (Strategies).
    Abstract: This book provides a cutting-edge scientific overview of Chinese liquor, also known as Baijiu. Chinese liquor is one of the world’s most ancient fermented alcoholic beverages. Fermented foods and beverages are consumed worldwide as an indispensable constituent in our daily life. However, most fermented foods rely on traditional techniques with limited known scientific knowledge. These indigenous processes are typically empirical without scientifically-based control and technological insights. The book analyses Chinese liquor processing on the three most important disciplines of fermented foods: process technology/engineering, flavor chemistry, and microbiology. It also addresses the perspectives and future research needs associated with spontaneous fermented foods. This book offers a deep understanding of the science of Chinese liquor production to students, researchers, and related practitioners both in the academic and the industry. It would also benefit many other fields of fermented foods for their optimization, standardization, and modernization.
    Type of Medium: Online Resource
    Pages: XIX, 608 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811921957
    DDC: 570.28
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Physiology. ; Medical genetics. ; Cell Biology. ; Physiology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Unconventional functions of transcription factors -- GAGA transcription factor -- Heterochromatin protein 1 -- Retinoblastoma protein -- STAT -- ATF-2 -- NF-kB -- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer -- STAT and HP1 promote longevity -- STAT and HP1 protect against DNA damage -- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model -- Chapter 4 The possible biological significance of transcription factors’ unconventional functions -- The epigenome -- Processes in the cell nucleus -- Future Work.
    Abstract: This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
    Type of Medium: Online Resource
    Pages: VI, 45 p. 6 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031290299
    Series Statement: SpringerBriefs in Biochemistry and Molecular Biology,
    DDC: 571.6
    Language: English
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  • 11
    Keywords: Aging. ; Cytology. ; Clinical biochemistry. ; Proteins . ; Ageing. ; Cell Biology. ; Medical Biochemistry. ; Protein Biochemistry.
    Description / Table of Contents: Chapter 1:Introduction: Historical Development and Progression of Clinical Research on Ageing -- Chapter 2:Bone Cells Metabolic Changes Induced by Ageing -- Chapter 3:Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-related Diseases -- Chapter 4: Heart Disease and Ageing: The roles of Senescence, Mitochondria and Telomerase in Cardiovascular Disease -- Chapter 5: Chronic Kidney Disease and the Exposome of Ageing -- Chapter 6: Sarcopenia and Ageing -- Chapter 7: Tendon Ageing -- Chapter 8: Virus Infections in Older People -- Chapter 9: Models and Biomarkers for Ovarian Ageing -- Chapter 10: Ageing and the Autonomic Nervous System -- Chapter 11: Astrocytes in Ageing -- Chapter 12: Hearing and Ageing -- Chapter 13: Melatonin and Ageing -- Chapter 14: Protein and Energy Supplements for the Elderly -- Chapter 15: Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants -- Chapter 16: Clinical Ageing.
    Abstract: This book provides an up-to-date overview of key areas of ageing research and bridges the gap between the subcellular events and the reality of ageing as seen in clinical practice. To this end, the reader learns about the historical development and progression of clinical ageing research. All chapters address the biochemistry or cell biology of various ageing events (to the extent that the data are available) and work their way to the clinical understanding we have of ageing. The focus of this volume is on how dietary restriction, virus infection and chronic inflammation affect the ageing process. Additionally, this book discusses how phosphate metabolism and metabolic dysfunction contribute to ageing events and how various organs and tissues (e.g. tendons, ears, heart muscle, and the endocrine system) age. This book follows on from Parts I, II and III of Biochemistry and Cell Biology of Ageing within the Subcellular Biochemistry book series and aims to bring the subcellular and clinical areas into closer contact by including interesting and significant biomedical ageing topics that were not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.
    Type of Medium: Online Resource
    Pages: VIII, 458 p. 48 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031265761
    Series Statement: Subcellular Biochemistry, 103
    DDC: 571.878
    Language: English
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  • 12
    Keywords: Zoology. ; Animal culture. ; Invertebrates. ; Zoology. ; Animal Science. ; Invertebrate Zoology.
    Description / Table of Contents: Chapter 1. Nature And Sources of Data For Inland Fisheries Management -- Chapter 2. Concept of Sampling Methodologies and Their Applications -- Chapter 3. Descriptive Statistics for Inland Fisheries Data -- Chapter 4. Basic Concept of Hypothesis Testing and Parametric Test -- Chapter 5. Chi–Square Test of Significance -- Chapter 6. Use of Non–Parametric Test in Fisheries Data -- Chapter 7. Analysis of Variance (Anova) and Design of Experiments -- Chapter 8. Concept of Simple Correlation and Regression -- Chapter 9. Analysis and Interpretation of Weight–Length Data of Fish -- Chapter 10. Some Multivariate Analysis Techniques for Fisheries Data -- Chapter 11. Introduction to Electronic Spreadsheet and Microsoft Excel -- Chapter 12. Introduction to R Software -- Chapter 13. Introduction To Graphics in R.
    Abstract: This authored book is primarily for the readers who are in search of how to use basic concepts of statistics in the field of fishery science. It has been written for the new comers coming in the fishery sector including university students, teachers and research scholars. It enriches the reader’s knowledge of data analysis step by step starting from data collection to its analysis and interpretation along with practical application with real example. It supports readers for enhancing theoretical and practical concept of application of fundamental statistics in fishery domain. Reader may also learn how to analyses data using different statistical software. Each chapter starts with an introduction of the topic followed by statistical concept with example and ends with chapter based question for comprehension purpose. This book is of interest to teachers, researchers, scientists, capacity builders in fishery sciences. Also the book serves as additional reading material for undergraduate and graduate students of fisheries and aquatic sciences.
    Type of Medium: Online Resource
    Pages: XXVIII, 257 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811944116
    DDC: 590
    Language: English
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  • 13
    Keywords: Zoology. ; Veterinary medicine. ; Freshwater ecology. ; Marine ecology. ; Zoology. ; Veterinary Science. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Chapter 1. Who are the marine mammals? -- Chapter 2. Marine mammal acoustics -- Chapter 3. Whaling, seal culling, and the effect of fisheries on marine mammals -- Chapter 4. Plastic debris and its impacts on marine mammals -- Chapter 5. Chemical pollution and diseases of marine mammals -- Chapter 6. How to become a marine mammal scientist.
    Abstract: This highly-readable Open Access textbook provides basic background information about marine mammals and anthropogenic impacts on them. The book includes inspiring exercises for education school programs in natural sciences. The book also provides advice on career paths using case studies of marine scientists and veterinarians describing their journeys from student to profession. By sharing real-life career paths, readers find answers to questions such as “What needs to be considered when choosing a career in science?” and “What kind of tasks do scientists undertake on a daily basis?” Marine mammals are amongst some of the most celebrated creatures on Earth, with their high intelligence, social and communicating skills, and capacity for deep diving. Alongside general information about marine mammals, the book aims at generating awareness of the impact of litter and noise pollution on the marine environment using marine mammals as an example. Huge numbers of marine animals, including marine mammals, die every year from entanglement in fishing gear, by ingestion of litter or because of chemical pollution. In the last decade many technological and scientific tools have been developed to aid research, for instance miniaturised sound recorders which can be attached to cetaceans and seals and record noise levels around them, their vocal production as well as their diving behaviour. This Open Access textbook can be used by undergraduate students interested in the fundamentals of marine mammal biology and medicine, and in pursuing the profession of a marine scientist. .
    Type of Medium: Online Resource
    Pages: X, 95 p. 32 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031068362
    DDC: 590
    Language: English
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  • 14
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Plant diseases. ; Molecular biology. ; Genetics. ; Plant Pathology. ; Molecular Biology. ; Genetics and Genomics.
    Description / Table of Contents: 1. Genomics of crucifers’ host-pathosystem - Prologue -- 2. Crucifers’ pathogens genome -- 3. Genomics of host- pathogen interaction -- 4. Molecular detection and Identification of pathogens, pathotypes and genes -- 5. Pathogenomics of pathogenic variability -- 6. Bio-metabolomics of crucifer’s host-pathosystem -- 7. Genomics of crucifer’s host-pathosystem at a glance -- 8. Protocols to study host-pathosystem -- 9. Future research priorities of crucifers’ host pathosystem -- 10. Subject index.
    Abstract: The book deals with latest research achievements of Brassica scientists using omics approaches in understanding host-pathogen interaction, molecular detection, identification, and functional characterization of effectors/genes including pathogenomics and biometabolomics. Genomics of host-pathogen interaction is a source of information for the teachers, students, researchers, and policy makers to foster success in enhancing the Brassica production and productivity through the development of improved disease-resistant varieties with the use of omics technologies. It is a base and sound plate form for managing biological stresses of Brassica at global level. The book covers up-to-date information on genomics of host-pathogen interaction, pathogenomics of crucifers’ pathogen, and biometabolomics of host pathosystem supplemented with ample photographs, illustrations, and figures which make it stimulating, effective, and easy to comprehend for readers, researchers, biology students, teachers, and policy makers.
    Type of Medium: Online Resource
    Pages: XXIII, 930 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811938122
    DDC: 571.92
    Language: English
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  • 15
    Keywords: Ecology Methodology. ; Biotic communities. ; Plant ecology. ; Ecological Modelling. ; Ecosystems. ; Plant Ecology.
    Description / Table of Contents: 1. Modelling tools and plausible scenarios in science-policy to improve evidence based decision making for human-well-being -- 2. Basic Introduction to Species Distribution Modelling -- 3. Machine Learning based predictive modelling approaches for better understanding evolutionary history, distribution and niche occupancy: Experience from Western Ghats -- 4. Mapping the impact of climate change on eco-sensitive hotspots using species distribution modelling (SDMs) – Gaps, Challenges and Future Perspectives -- 5. Approaches for modelling the climate change impacts on ecosystems -- 6. Developing a Bayesian Model of Climate-Induced Lake Overturn in Talisay, Taal Lake -- 7. Global sensitivity and uncertainty analysis of MaxEnt model: Implications in species habitat projections -- 8. Tree species diversity and richness patterns reveal high priority areas for conservation in Eswatini -- 9. Improving the conservation status of a threatened tree (Acer sikkimensis Miq. syn. Acer hookeri Miq.) through standardization of seed germination protocol and using ecological niche modeling -- 10. Ecological Niche Modeling of the endemic Himalayan near-threatened treeline conifer Abies spectabilis (D.Don) Mirb. in the Indian Central Himalaya -- 11. Modeling the distribution of a medicinal plant Oroxylum indicum (L.) Kurz for its conservation in Arunachal Pradesh -- 12. Habitat Suitability and Niche Modeling for Conservation and Restoration of Aconitum heterophyllum Wall. in Temperate Himalayan Forest Ecosystem -- 13. Application of species distribution modeling for conservation and restoration of forest ecosystems -- 14. Habitat suitability analysis of Asiatic Elephants (Elephas maximus) in the Tropical Moist Deciduous Forest of Assam using Analytic Hierarchy Process (AHP) -- 15. Factors Affecting the Habitat Suitability of Eastern Swamp Deer (Rucervus duvaucelii ranjitsinhi Groves, 1982) in Manas National Park and Implication for Terai Grassland Restoration -- 16. Evaluating Potential Habitats of Chital, Sloth Bear and Jungle Cat in Selected Areas of Central Indian Landscape -- 17. Habitat suitability modeling of Tor tor (Hamilton, 1822) in the Indian drainage systems using MaxEnt -- 18. Modelling the influence of Marine Fishery Advisories on the reduction of Carbon Dioxide emissions for Odisha under varying Climate Change Scenarios using CMIP models – an evidence-based approach for policymaking -- 19. Impacts of pollution on tropical montane and temperate forests of South Asia: Preliminary studies by post graduate students in India and Sri Lanka -- 20. Selection of strategic sampling sites for river quality assessments near mined areas as a policy handle for low-impact development and biodiversity conservation – a case study of River Godavari -- 21. Ecological niche modeling predicts the potential area for cultivation of Melia dubia Cav. (Meliaceae): a promising tree species for agroforestry in India -- 22. Proportions of change in the airborne particulate matter (PM10) concentrations across selected states in Peninsular India - a study of decadal, pre-pandemic trends for planning restoration -- 23. Decomposition of Sunflower Cuttings and its Impact on Soil Fertility of Rice Terraces (Payoh) in Banaue, Ifugao, Philippines -- 24. Forest ecosystem modeling for policy planning: A review -- 25. Ecological Carrying Capacity Modelling and Sustainability Assessment of the Seven Lakes of San Pablo City, Laguna, Philippines -- 26. Assessment of the contribution of Fresh Water Ecosystem Services to the Hydropower Sector in the Kura-Araz basin -- 27. Eutrophication modelling of Chilika Lagoon using an artificial neural network approach.
    Abstract: This edited book is focused on SDG 15. This volume covers aspects of species and ecosystem modeling in understanding the complexity of ecological systems, restoration, protected area management, and species conservation. The book follows a systematic and situation-sensitive approach to discuss ecosystem and species modeling tools, approaches, science, case studies, opportunities, and gaps for enhancing conservation efforts, ensuring ecosystem resilience, and addressing sustainability issues. The book emphasizes on science, innovations, case studies, and strategic relevance as main pillars of using ecosystem and species modeling tools and implementing the outcomes and results. In addition, clear conceptual frameworks, elaborated methodologies, and their applications are included to support policy planning and interventions to reduce and reverse human encroachment in human-dominated natural ecosystems, their degradation, and loss of important species and ecosystem services. Essential information with a special focus on advances and opportunities in advancing the implementation of results and outputs of the modeling tools, challenges and constraints for addressing loss of ecosystem services, designing and implementing sustainable landscape restoration, environmental risk assessment, and finally understanding policy implications and concerns for mainstreaming modeling results in conservation planning and decision-making is included in the book. Further topics include ultimate translational value of modeling tools and efforts across transitional ecosystems and species habitat to provide better evidence to influence the nature-based solutions (NbS) and ecosystem health assessment using Red List of Ecosystems (RLE). The emerging roles of integrative socio-ecological as well as techno-cultural factors in promoting the relevance of ecosystem and species modeling is one of the key features of this book. This edited volume is of interest and useful to researchers, students, scholars, policy makers, forest managers, consultants, and policy makers in the fields of protected area management, forest department, conservation, modeling, climate change, and sustainability science, and also authors engaged in IPBES, IPCC, and several other assessments.
    Type of Medium: Online Resource
    Pages: XXXV, 570 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819901319
    DDC: 577
    Language: English
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  • 16
    Keywords: Neurosciences. ; Pain medicine. ; Neurology . ; Anesthesiology. ; Neuroscience. ; Pain Medicine. ; Neurology. ; Anesthesiology.
    Description / Table of Contents: Introduction to Acute, Chronic, and Episodic Pain -- Inflammation and Pain -- Animal Models of Pain and Anti-inflammatory Treatments -- Inflammatory Mediators, Nociceptors, and Their Interactions in Pain -- Immune and Glial Cells in Pain and Their Interactions with Nociceptive Neurons -- Sex Differences in Neuroimmune Interactions and Pain -- Neuroimmune Interactions in Itch -- Toll-like Receptors in Pain and Itch -- Immunotherapy and Pain -- Cell Therapy and Regenerative Pain Medicine - Preclinical Studies -- Cell-based Therapies in Pain Management -- Platelet-Rich Plasma and Autologous Conditioned Serum: Non-Cellular Biologic Therapies for Neuroimmune Modulation and the Treatment of Arthritis Pain -- Exercise and Diet in the Control of Inflammation and Pain -- Mechanism-Based Pain Therapies -- Neuromodulation in Pain Management -- What Patients Need to Know about Pain Therapy?.
    Abstract: As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
    Type of Medium: Online Resource
    Pages: X, 364 p. 45 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031292316
    DDC: 612.8
    Language: English
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  • 17
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Toxicology. ; Machine learning. ; Artificial intelligence. ; Toxicology. ; Machine Learning. ; Artificial Intelligence.
    Description / Table of Contents: Machine Learning and Deep Learning Promotes Predictive Toxicology for Risk Assessment of Chemicals -- Multi-Modal Deep Learning Approaches for Molecular Toxicity prediction -- Emerging Machine Learning Techniques in Predicting Adverse Drug Reactions -- Drug Effect Deep Learner Based on Graphical Convolutional Network -- AOP Based Machine Learning for Toxicity Prediction -- Graph Kernel Learning for Predictive Toxicity Models -- Optimize and Strengthen Machine Learning Models Based on in vitro Assays with Mecha-nistic Knowledge and Real-World Data -- Multitask Learning for Quantitative Structure-Activity Relationships: A Tutorial -- Isalos Predictive Analytics Platform: Cheminformatics, Nanoinformatics and Data Mining Applications -- ED Profiler: Machine Learning Tool for Screening Potential Endocrine Disrupting Chemicals -- Quantitative Target-specific Toxicity Prediction Modeling (QTTPM): Coupling Machine Learning with Dynamic Protein-Ligand Interaction Descriptors (dyPLIDs) to Predict Androgen Receptor-mediated Toxicity -- Mold2 Descriptors Facilitate Development of Machine Learning and Deep Learning Models for Predicting Toxicity of Chemicals -- Applicability Domain Characterization for Machine Learning QSAR Models -- Controlling for Confounding in Complex Survey Machine Learning Models to Assess Drug Safety and Risk. .
    Abstract: This book is a collection of machine learning and deep learning algorithms, methods, architectures, and software tools that have been developed and widely applied in predictive toxicology. It compiles a set of recent applications using state-of-the-art machine learning and deep learning techniques in analysis of a variety of toxicological endpoint data. The contents illustrate those machine learning and deep learning algorithms, methods, and software tools and summarise the applications of machine learning and deep learning in predictive toxicology with informative text, figures, and tables that are contributed by the first tier of experts. One of the major features is the case studies of applications of machine learning and deep learning in toxicological research that serve as examples for readers to learn how to apply machine learning and deep learning techniques in predictive toxicology. This book is expected to provide a reference for practical applications of machine learning and deep learning in toxicological research. It is a useful guide for toxicologists, chemists, drug discovery and development researchers, regulatory scientists, government reviewers, and graduate students. The main benefit for the readers is understanding the widely used machine learning and deep learning techniques and gaining practical procedures for applying machine learning and deep learning in predictive toxicology. .
    Type of Medium: Online Resource
    Pages: XIX, 635 p. 149 illus., 124 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031207303
    Series Statement: Computational Methods in Engineering & the Sciences,
    DDC: 615.90072
    Language: English
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  • 18
    Keywords: Biology. ; Biotechnology. ; Biophysics. ; Renewable energy sources. ; Biological Sciences. ; Biotechnology. ; Biophysics. ; Renewable Energy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Biotechnology and Its Connection to Renewable Energies: Biofuels Production -- Chapter 3. Biotechnological Formation of Biogas -- Chapter 4. Biotechnology in Bioethanol Generation -- Chapter 5. Biological Methods for Diesel Formation -- Chapter 6. Biotechnological-based Production of Bio-Oil and Vegetable Oil -- Chapter 7. Biotechnology in Hydrogen Generation -- Chapter 8. Global Conclusions and Future Perspectives.
    Abstract: This book approaches biofuels from a new biotechnological perspective with the aim of equipping researchers with a thorough, up-to-date understanding of biofuel research and related technologies. Topics include biomethane, bioethanol, biobutanol, biomass, hydrolysis, bio-oil, microbiology, and many more. Biofuel research has evolved mechanisms to advance their utilization and their application in our system. The chapters will provide concise and up-to-date information to aid our understanding of biotechnology-related implications of biofuels development and its advancements. Readers in the areas of bioengineering, sustainability, renewable energies and biotechnology will find this work useful to widen their knowledge and perspectives on biofuels.
    Type of Medium: Online Resource
    Pages: X, 147 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811991875
    Series Statement: Interdisciplinary Biotechnological Advances,
    DDC: 570
    Language: English
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  • 19
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Plant anatomy. ; Biodiversity. ; Plant Science. ; Plant Anatomy and Morphology. ; Biodiversity.
    Description / Table of Contents: Part I – User manual and architectural concepts. Chapter 1. Introduction -- Chapter 2. How to use this book 6 -- Chapter 3. Architectural concepts and key to the models -- Part II. Identification keys -- Chapter 4. Key to the groups of families of trees and shrubs (groups 1 to 52) -- Chapter 5. Keys to families of trees and shrubs -- Chapter 6. Supplementary keys -- Chapter 7. Keys to the groups of families of lianas and woody epiphytic (groups 53 to 57) -- Chapter 8. Keys to families of lianas and woody epiphytes -- PART III. Description of the families -- Chapter 9. Acanthaceae to Asteraceae -- Chapter 10. Bignoniaceae to Buxaceae -- Chapter 11. Cactaceae to Cycadaceae -- Chapter 12. Dichapetalaceae to Dipterocarpaceae -- Chapter 13. Ebenaceae to Euphorbiaceae -- Chapter 14. Fagaceae -- Chapter 15. Gentianaceae to Goupiaceae -- Chapter 16. Hamamelidaceae to Humiriaceae -- Chapter 17. Icacinaceae s.l. to Irvingiaceae -- Chapter 18. Juglandaceae -- Chapter 19. Lamiaceae to Lythraceae -- Chapter 20. Magnoliaceae to Myrtaceae -- Chapter 21. Nyctaginaceae,- Chapter 22. Ochnaceae to Oxalidaceae -- Chapter 23. Pandaceae to Putranjivaceae -- Chapter 24. Rhabdodendraceae to Rutaceae -- Chapter 25. Sabiaceae to Symplocaceae -- Chapter 26. Tetramelaceae to Torricelliaceae -- Chapter 27. Ulmaceae s.l. to Urticaceae -- Chapter 28. Verbenaceae to Vochysiaceae -- Chapter 29. Zygophyllaceae s.l -- Chapter 30. Herbaceous versus arborescent habit in the families and orders of flowering plants - evolutionary trends.
    Abstract: This book provides an identification system permitting recognition of plant families in all seasons by means of morphological and macroanatomical features which are easily observable, such as bark, exudates, stems and leaves characters. Studies of forest vegetation may differ in their underlying objectives, but they all require taxonomic knowledge. The process of taxonomy begins with an inventory of the flora, which has been based to a large extent on reproduction-related organs, such as flowers and fruits. But, those are often difficult to observe and may not exist in the field at a given time. Unlike most such guides or keys, this book can be used anywhere in the tropics and provides, in a straightforward two or three-step process, identification to the level of families, which are now circumscribed according to molecular as well as morphological characters in the universally accepted scheme of the Angiosperm Phylogeny Group. Plant architecture is not a prerequisite theme for plant identification; however, we think that an introduction to this subject is not out of place in this book (architectural traits are taxonomically sound): it is now time for botanists working in the tropics to have an idea on how the whole organism keeps growing. Within the family accounts, there is information concerning important economic plants with notes on the larger genera and, particularly helpfully, discussion of families readily confused and how to separate them. Descriptions of the families rely on short diagnosis bolstered by many photographic pictures, lines drawings and extracts from the author’s field books, all showing features of plants as they are found in the forest.
    Type of Medium: Online Resource
    Pages: XVII, 494 p. 909 illus., 850 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031059421
    DDC: 580
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Veterinary medicine. ; Agriculture. ; Physiology. ; Agricultural genome mapping. ; Animal welfare Moral and ethical aspects. ; Veterinary Science. ; Agriculture. ; Animal Physiology. ; Agricultural Genetics. ; Animal Ethics.
    Description / Table of Contents: Chapter 1. Putting Smart into Nutrition -- Chapter 2. Mozatching Feed Characteristics to Animal Requirements Through Plant Breeding -- Chapter 3. Circular Feed Production and Consumption in The Context Of Smart Animal Nutrition -- Chapter 4. Assessment of The Nutritive Value of Individual Feeds and Diets by Novel Technologies -- Chapter 5. Large Scale Phenotyping and Genotyping: State of The Art and Emerging Challenges -- Chapter 6. Mathematical and Statistical Approaches to The Challenge of Forecasting Animal Performance for The Purposes of Precision Livestock Feeding -- Chapter 7. Smart Pig Nutrition in the Digital Era -- Chapter 8. Smart Poultry Nutrition -- Chapter 9. Advanced Technology in Aquaculture – Smart Feeding in Marine Fish Farms -- 10. Smart Nutrition of Extensively Kept Ruminants -- Chapter 11. The Potential Contribution of Smart Animal Nutrition in Reducing The Environmental Impacts of Livestock Systems.
    Abstract: This book highlights the latest findings and techniques related to nutrition and feed efficiency in animal agriculture. It addresses the key challenges facing the nutrition industry to achieve high animal productivity with minimal environmental impact. The concept of smart nutrition involves the use of smart technologies in the feeding and management of livestock. The first chapters focus on advances in biological fields such as molecular agriculture and genotype selection, as well as technologies that enhance or enable the collection of relevant information. The next section highlights applications of smart nutrition in a variety of livestock systems, ranging from intensive indoor housing of broilers and pigs to extensive outdoor housing of cattle and sheep, and marine fish farms. Finally, because of the worldwide attention to this issue, the authors address the environmental consequences. This work, which takes a serious look at how nutrition can be used to improve sustainability in animal agriculture, is a key literature for readers in animal and veterinary sciences, the food industry, sustainability research, and agricultural engineering.
    Type of Medium: Online Resource
    Pages: VIII, 336 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031225840
    Series Statement: Smart Animal Production, 1
    DDC: 636.089
    Language: English
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  • 21
    Keywords: Food science. ; Sustainability. ; Family-owned business enterprises. ; Economics. ; Food Science. ; Sustainability. ; Family Business. ; Economics.
    Description / Table of Contents: Chapter 1 Bread Industry Sustainability Life Cycle Assessment -- Chapter 2 Product Environmental Footprint and Bread Industry -- Chapter 3 Life Cycle Assessment and Product Environmental Footprint - recommendations for integral optimization of economic and environmental performance -- Chapter 4 Ensuring sustainability of baking industry in North Macedonia -- Chapter 5 Sustainability approach of the baking industry along the food supply chain -- Chapter 6 Sustainability assessment of the baking industry complying with standards requirements: a case of Romania -- Chapter 7 Across American overview on sustainability approach throughout baking industry: An analytical-descriptive approach -- Chapter 8 Asian Overview on Sustainability Approach in Baking Industry -- Chapter 9 African Experience in Ensuring Sustainability in Baking -- Chapter 10 Indian experience in ensuring sustainability in baking industry -- Chapter 11 Measuring Baking Business Performance -- Chapter 12 Forming the efficient business model for bakery -- Chapter 13 Assessment of the sustainable competitiveness of agricultural enterprises on the grain market: case of Ukraine -- Chapter 14 Economic viability and sustainability in baking industry/ Simeuna - bread producer with own grain production -- Chapter 15 Impact of Bakery Innovation on Business Resilience Growth -- Chapter 16 Innovation in the commercial system of the small bakery industry -- New business models in food systems for farmers and companies, based on multi-actor approach -- Chapter 18 The role of rural women in bread industry – Job creation and retention in rural areas.
    Abstract: This timely and comprehensive text focuses on important recent advances in applied sustainability in the baking industry, connecting all of the current methods and strategies into a single book. Those involved in bread production will find the latest developments at the theoretical and practical levels, including information and communication requirements, reporting and regulatory aspects, economic and environmentally sustainable business models, supply chain management, life cycle assessment, product and organizational environmental footprints and more. For small bakery business owners to industry leaders and policymakers, governmental authorities, regulatory authorities and standardization bodies, this book offers a compilation of technical information about sustainability in the market for the bakery sector. Baking Business Sustainability Through Life Cycle Management begins by presenting basic information on the life cycle assessment and product environmental footprint of the bread industry, proposing an analysis of sustainability assessment using environmental and social footprints and providing recommendations for integral optimization of economic and environmental performance. A second section focuses on sustainability in the baking industry, providing a regional focus from Europe to the Americas to Africa and Asia. The third section takes a deep look at economic feasibility and efficiency in the bread industry, including the economic viability of different scenarios for bread-based value chains, and forming efficient business models for bakeries. A final section zeroes in on the most up-to-date innovations in the current bakery industry, including the impact of bakery innovation on business resilience growth, commercial systems, and new business models in regional food systems for farmers and companies, based on multi-actor approach. Innovations within the bakery industry are at an all-time high, with new sustainability and economic models being introduced, along with associated market risks. This timely and ambitious text aims to cover all the most recent advances and methods for successful incorporation into bakery businesses. .
    Type of Medium: Online Resource
    Pages: VIII, 313 p. 74 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031250279
    DDC: 641.3
    Language: English
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  • 22
    Keywords: Agriculture. ; Food science. ; Plant biotechnology. ; Agriculture. ; Food Science. ; Plant Biotechnology.
    Description / Table of Contents: Chapter 1. Global scenario of temperate nuts -- Chapter 2. Nutritional composition of temperate nuts -- Chapter 3. Development and selection of rootstocks -- Chapter 4. Cultivars and genetic improvement -- Chapter 5. Improved propagation techniques in temperate nuts -- Chapter 6. Pollination management -- Chapter 7. Mineral nutrition -- Chapter 8. Plant water relations and Irrigation -- Chapter 9. Canopy architecture -- Chapter 10. Biotechnological interventions for improvement of temperate nuts -- Chapter 11. Organic approaches in temperate nuts -- Chapter 12. Shelf life enhancement -- Chapter 13. Package and storage of temperate nuts -- Chapter 14. Physiological disorders -- Chapter 15. Diseases of temperate nuts -- Chapter 16. Integrated pest management of temperate nuts.
    Abstract: This book focuses on the production technology of temperate nuts. It explores cultivar and plant improvement, development and selection of rootstocks, plant–water relations and irrigation, canopy architecture, and postharvest packaging of nut fruits. It also deals with organic approaches, biotechnological interventions, diseases, and pest management. Contributing authors address nut fruits such as walnut, pecan nut, chestnut, and hazel nut on different recent aspects. The development achieved in the fruit sector is indicative of the fact that there is growing demand of fruit produce. Temperate nuts with health benefits and market acceptability have best sources of fat, fiber, protein, and mineral. They provide dietary fiber, potassium, and a variety of health-protective bioactive compounds. Apart from the health benefits, production of temperate nuts improves the economy of the country as these are very good source of income and employment. In addition, there is wide diversification in the production pattern of nuts globally. Increased production technology such as hybrids, high-yielding selections/ varieties, improved propagation techniques, and increased use of fertilizers and manures have brought spectacular increase in the production of nut fruits. This book is of interest to teachers, scientists, researchers, and scholars. Also, the book serves as additional reading material for undergraduate and postgraduate students of agriculture and horticulture. Horticulture nurseries and orchard industries also find this to be a useful read.
    Type of Medium: Online Resource
    Pages: XIII, 385 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811994975
    DDC: 630
    Language: English
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  • 23
    Keywords: Biodiversity. ; Freshwater ecology. ; Marine ecology. ; Grassland ecology. ; Biodiversity. ; Freshwater and Marine Ecology. ; Grassland Ecology.
    Description / Table of Contents: Chapter 1. Fish and fisheries of the temperate Himalayas: An overview and way-forward -- Chapter 2. Fishery resources and ichthyofaunal diversity in the temperate Himalayas -- Chapter 3. Mapping of the Himalayan surface waters using remote sensing and geographic information system tools: An overview of single band-based techniques -- Chapter 4. Fisheries development in open water resources of the temperate Himalaya -- Chapter 5. Diversity and threat to coldwater fishes of river Torsa at the Terai region of West Bengal, India -- Chapter 6. The endangered mighty mahseer (Tor putitora) in the Himalayan waters -- Chapter 7. Aquaculture practices in the temperate Himalayan region -- Chapter 8. Status and prospects of rainbow trout farming in Himalayan waters -- Chapter 9. Fisheries and aquaculture of snow trouts in the Trans-Himalayan region -- Chapter 10. Ornamental Fisheries in Hindu Kush Himalayan Region -- Chapter 11. Recirculating aquaculture system for intensive fish farming in Indian Himalayan region: An overview -- Chapter 12. Coldwater fish nutrition in the Indian Himalayas -- Chapter 13. Molecular characterization and population structure of the important Himalayan fish species -- Chapter 14. Prospects and challenges of molecular interventions for enhancing aquaculture production in the temperate Himalayas -- Chapter 15. An overview of coldwater fish diseases and their control measuresChapter 16. Oomycetes, fungal-like menace in coldwater aquaculture -- Chapter 17. Antimicrobial peptides: An alternative to antibiotics for environment-friendly hill aquaculture -- Chapter 18. Advances in detection techniques for fungus-like organisms of aquaculture importance -- Chapter 19. Nutritional quality and human health benefits of important coldwater fishes of the Indian Himalayas -- Chapter 20. En-route towards aquaponics in coldwater: Identifying the gaps in principles and system design -- Chapter 21. Impact of climate change in temperate fisheries of the Himalayas and possible adaptation approaches -- Chapter 22. Livelihood opportunities with recreational fisheries and ecotourism -- Chapter 23. Design and operational principle of re-circulatory aquaponic system in the Himalayas: Prospects and challenges -- Chapter 24. Farm design and layout for aquaculture operations in the temperate Himalayas -- Chapter 25. Hydroelectric projects: An inevitable challenge in fisheries of the temperate Himalaya.
    Abstract: This book covers all aspects of fisheries and aquaculture of the temperate Himalayas, including fisheries resources, fish biodiversity, aquaculture status, prospects, and potential. It also includes mapping of resources, health and disease management of cultured species, feed and nutritional aspects of the cultured fish species, ornamental fisheries aspects, etc. In addition, it elucidates the recent advances in biotechnological interventions for enhancing fisheries and aquaculture productivity in the region. Essential information on the application of Geo Information System (GIS) for resource mapping, the scope of adopting re-circulatory aquaculture system for productivity enhancement, and trout culture in the Himalayan waters are provided in the book. A detailed account of recreational fisheries and fish-based ecotourism in the temperate Himalayas for generating livelihood has been provided. The impact of climate change on the fisheries of the Himalayas has been dealt with separately. The book also covers the conservation and rehabilitation aspects of endangered species of the region. This book will become a ready reference for the scientists, teachers, researchers, students, policymakers, and other stakeholders for managing fishery resources in the temperate Himalayas.
    Type of Medium: Online Resource
    Pages: XVI, 488 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811983030
    DDC: 333.95
    Language: English
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  • 24
    Keywords: Agricultural biotechnology. ; Botany. ; Agriculture. ; Agricultural Biotechnology. ; Plant Science. ; Agriculture.
    Description / Table of Contents: Chapter 1: Global climate perturbations: sustainable microbial mitigation strategies -- Chapter 2: Soil microflora and their interaction with plants under changing climatic scenarios -- Chapter 3: Beneficial microbial consortia and their role in sustainable agriculture under climate change conditions -- Chapter 4: Unfolding the role of beneficial microbes and microbial techniques on improvement of sustainable agriculture under climatic challenges -- Chapter 5: Microbes and their role in alleviation of abiotic and biotic stress tolerance in crop plants -- Chapterb 6: Plant-microbe interaction and their role in mitigation of heat stress -- Chapter 7: Role of soil microbes against abiotic stresses induced oxidative stresses in plants -- Chapter 8: An overview of the multifaceted role of plant growth promoting microorganisms and endophytes in sustainable agriculture: Developments and prospects -- Chapter 9: Plant growth promoting rhizobacteria (PGPR): an indispensable tool for climate resilient crop production -- Chapter 10: Plant endophyte interactions- a driving phenomenon for boosting plant health in the face of climate change -- Chapter 11: Deciphering the role of growth promoting bacterial endophytes in harmonizing plant health -- Chapter 12: Endophytic microbes and their role in plant health -- Chapter 13: Multitrophic Reciprocity of AMF with Plants and Other Soil Microbes in Relation to Biotic Stress -- Chapter 14: Effect of temperature and defence response on the severity of dry root rot disease in chickpea caused by Macrophomina phaseolina -- Chapter 15: Emerging roles of plant growth promoting rhizobacteria in salt stress alleviation: applications in sustainable agriculture -- Chapter 16: Studies on orchidoid mycorrhizae and mycobionts. associated with orchid plants as plant growth promoters and stimulator in seed germination -- Chapter 17: Current status of mycorrhizal biofertilizer in crop improvement and its future prospects -- Chapter 18: New developments in techniques like metagenomics. metaproteomics for isolation. identification. and characterization of microbes from varied environment -- Chapter 19: Mushroom metagenome: tool to unravel interaction network of plant. mycorrhiza and bacteria -- Chapter 20: Extremophile bacterial and archaebacterial population: metagenomics and novel enzyme reserve -- Chapter 21: Microbial nanotechnology: a biocompatible technology for sustainable and green agriculture practice -- Chapter 22: Bacteriophage Assisted Diagnostics and Management of Plant Diseases.
    Abstract: This book provides a comprehensive understanding of the complex relationship between microbial symbionts and plants in the era of climate change. It focuses on the plant microbiome associated with different plant organs like roots, leaves, stems, fruit, and seeds, and showcases their significant role in the enhancement of crop yield and protection in a sustainable manner. Concomitantly, acumens to the most emerging trends in plant microbial research that includes rhizosphere engineering and metagenomics are also covered in this title. The association of microbial symbionts with the host offers a wide advantage in terms of acclimatization to varied environmental conditions. A large number of microbes such as cyanobacteria, PGPR, endophytes, and AMF have been shown to improve plant growth and production under the effect of various abiotic and biotic stresses. These microbial symbionts secrete several secondary metabolites, signaling molecules, and hydrolytic enzymes that play a multifarious role in improving plant growth and yield. Moreover, the symbionts have been known to regulate the host responses at the molecular level. Bioprospecting these microbial symbionts will provide an alternative to the chemical-based fertilizers and pave the path for the development of biofertilizers. The book is a suitable reading material for undergraduate and postgraduate students, researchers, and scientists working in the field of agricultural biotechnology, microbiology, mycology and plant pathology, and allied fields of plant and microbial sciences. The book in this context attempts to provide an integrative and exhaustive study as well as research material that would help the scientific community in wide respect. .
    Type of Medium: Online Resource
    Pages: XVIII, 582 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819900305
    Series Statement: Rhizosphere Biology,
    DDC: 630
    Language: English
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  • 25
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nutrition   . ; Medical microbiology. ; Human physiology. ; Medicine, Preventive. ; Health promotion. ; Nutrition. ; Medical Microbiology. ; Human Physiology. ; Health Promotion and Disease Prevention.
    Description / Table of Contents: Chapter 1. Physiological and Metabolic Functions of the Intestinal Epithelium: From the Small to the Large Intestine -- Chapter 2. Intestine Offers Board and Lodging for Intestinal Microbes on a Short- or Long-Term Stay -- Chapter 3. Metabolism of Dietary Substrates by Intestinal Bacteria and Consequences for the Host Intestine -- Chapter 4. Alimentation, Bacterial Metabolites, and Host Intestinal Epithelium -- Chapter 5. Modification of the Bacterial Metabolites by the Host after Absorption, and Consequences for the Peripheral Tissues’ Metabolism, Physiology, and Pathophysiology -- Chapter 6. Lessons to Be Learned from Clinical and Experimental Research on the Intestinal Microbiota Metabolic Activity for Health Benefit and Perspectives.
    Abstract: This book provides an overview of the metabolism of dietary compounds by the intestinal microbiota, and on the consequences of such metabolic activity on host metabolism and physiological functions; both in intestinal and peripheral tissues. Over the last years, our understanding of the causal links between microbiota metabolic activity towards dietary and endogenous substrates and human health status has evolved extensively. In this context, the book starts with a comprehensive introduction devoted to the physiological and metabolic functions of the intestinal epithelium, followed by a part dedicated to the way intestine offers board and lodging for microbes being on a short- or long-term stay. The next chapters focus on the utilization of the available substrates from diet by the intestinal bacteria to produce numerous bacterial metabolites, and on the impact of such microbial activity, in the first place for communication between microbes, and for communication between microbes and lodging host. As will be detailed, this latter process of interkingdom communication leads to either beneficial or deleterious effects on intestinal physiology and metabolism. Special attention is given to selected pathophysiological processes namely chronic intestinal inflammation, colorectal carcinogenesis, and diarrhea. Then, the effects of modifications of bacterial metabolites and other bioactive compounds by the host after intestinal absorption, and consequences for peripheral tissue functions are presented. Summarizing the state of the art on what is known about the metabolic crosstalk between gut microbiota and human metabolism, as well as perspectives for further experimental and clinical research, this book provides a useful resource for researchers, professionals, and students with a background in biology, and/or nutrition, medicine, pharmacology, and for those which are involved in the agriculture and food production. By explaining technical terms all along the text, this book should be understandable also for interested non-specialists.
    Type of Medium: Online Resource
    Pages: XIII, 254 p. 57 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031263224
    DDC: 613.2
    Language: English
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  • 26
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Ecology . ; Environmental sciences Mathematics. ; Environment. ; Conservation biology. ; Statistics . ; Ecology. ; Mathematical Applications in Environmental Science. ; Environmental Sciences. ; Conservation Biology. ; Statistics.
    Description / Table of Contents: 0. Introduction - Ecologist in Wonderland -- Part 1. Linking Ecotoxicology and Ecology -- Chapter 1. Basic Concepts of Ecological Risk Assessment -- Chapter 2. Population-level assessment -- Chapter 3. Population models of extinction -- Chapter 4. Population level assessment using the canonical model -- Part 2. Models for ecotoxicology -- Chapter 5. Species Sensitivity Distribution in Ecological Risk Assessment -- Chapter 6. BLM: A model for predicting metal toxicities -- Chapter 7.Mathematical models for chemical mixtures -- Chapter 8.Statistics and related topics.
    Abstract: This book introduces various mathematical models used in ecological risk assessment, primarily discussing models used in hazard assessment. The book aims to link ecology and conservation biology with risk assessments, bringing together the knowledge of ecotoxicology and ecology for effective risk assessment. The first part describes population-level assessment in ecological risk assessment. The chapters cover current methodologies for ecological risk assessment, individual-level assessment, population dynamics models for population-level assessment, case studies, mathematical models for population extinctions, the derivation of mean time to extinction (MTE) and their case studies. The second part of the book discusses the mathematical models involved in hazard assessments. It introduces the method of risk assessment using species sensitivity distributions (SSDs), hazard assessment of metals, chemical mixtures using the Michaelis-Menten equation, basic elements of statistics and related topics. Expected readers are risk assessors in governments and public sectors, students and young researchers interested in environmental science. The book is made accessible and easy to follow by beginners in mathematical biology and theoretical ecology.
    Type of Medium: Online Resource
    Pages: XIV, 202 p. 90 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819903092
    Series Statement: Theoretical Biology,
    DDC: 577
    Language: English
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  • 27
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Regenerative medicine. ; Biomedical engineering. ; Cytology. ; Biomaterials. ; Cells. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Engineering and Bioengineering. ; Cell Biology. ; Biomaterials-Cells. ; Biotechnology. ; Biomaterials.
    Abstract: Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges are highlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: X, 326 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031266256
    Series Statement: Advances in Experimental Medicine and Biology, 1413
    DDC: 612.028
    Language: English
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  • 28
    Keywords: Medicine Research. ; Biology Research. ; Cardiovascular system. ; Physiology. ; Cardiology. ; Clinical biochemistry. ; Biomedical Research. ; Cardiovascular Physiology. ; Cardiology. ; Medical Biochemistry.
    Description / Table of Contents: Past, present and future perspectives of renin angiotensin system -- Biochemical pathways of renin angiotensin system -- Structure-function relationships of angiotensin II receptors -- Signal transduction mechanism of angiotensin II -- Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection -- Angiotensin II and the pathogenesis of hypertension -- Signaling transduction of angiotensin II in hypertension -- Role of angiotensin II type 1 receptors in vascular remodeling in hypertension -- Molecular and cellular mechanisms of renin-angiotensin system in hypertension -- Tissue renin-angiotensin system and risks in hypertension -- Oxidative stress and angiotensin II-induced hypertension -- Angiotensin II: inflammatory system disorder and hypertension -- Therapeutic approaches for angiotensin receptor blockers in hypertension -- Renin-angiotensin systems: A pivotal role in the development of atherosclerosis -- Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis -- Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability -- Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis -- The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation -- Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis -- Effects of angiotensin-converting enzyme and receptors in atherosclerosis -- Effects of angiotensin II on cardiac arrhythmia and signal transduction -- Angiotensin II induced oxidative stress contribute to ventricular arrhythmias -- Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias -- ACE inhibitor and ventricular arrhythmia in ischemic heart disease -- The renin-angiotensin system modulators and cardiac arrhythmias -- Angiotensin receptor blockers in the treatment of arrhythmias -- Angiotensin II induced cardiac hypertrophy and heart failure -- Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure -- Renin-angiotensin system: Molecular and cellular mechanisms in heart failure -- Role of angiotensin II receptor mRNA expression in heart failure -- Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure -- Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure -- Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure -- Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update -- Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure.
    Abstract: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
    Type of Medium: Online Resource
    Pages: XVIII, 452 p. 71 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031149528
    Series Statement: Advances in Biochemistry in Health and Disease, 24
    DDC: 610.72
    Language: English
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  • 29
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biodiversity. ; Ecology . ; Forestry. ; Biodiversity. ; Ecology. ; Forestry.
    Description / Table of Contents: 1. Climbers - a general overview -- 2. Overview of the research on climbers from the past to the present: a global analysis -- 3. Ecology of Lianas: Diversity and distribution -- 4. Current status and future prospects -- 5. Taxonomic diversity of climbing flora in India – A compendium -- 6. Climber radiations in Angiosperms: How many families have climbers?
    Abstract: This book brings out the most comprehensive and up-to-date information on the taxonomy, biodiversity, and ecology of climbers in India. Climbing is one of the principal plant growth habits that have long attracted the interests of ecologists and evolutionary biologists. Climbing plants can add significantly to the species richness of many tropical forests ecosystems, yet they receive relatively lesser attention than trees in ecological studies. The difficulties in taxonomic assertions and lack of standard methodologies overlook climbers in plant inventories, resulting in the underrepresentation of climbers in regional floras. There is a growing consensus about the increasing abundance of climbers and their multifaceted role in tropical forests worldwide. Therefore, it is essential to understand the taxonomic diversity and ecology of climbers at the regional scale to substantiate our efforts towards constructing a global climber database, which serves as a reference for fundamental research in climber ecology and evolution. This book is of interest to biodiversity researchers, taxonomists, ecologists, and evolutionary biologists. Field biologists, forest managers, and naturalists will also find this a useful read.
    Type of Medium: Online Resource
    Pages: XI, 922 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811986451
    DDC: 333.95
    Language: English
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  • 30
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Food science. ; Agriculture. ; Economic geography. ; Botany. ; Environmental management. ; Food Science. ; Agriculture. ; Economic Geography. ; Plant Science. ; Environmental Management.
    Description / Table of Contents: Chapter 1: Saffron and Tulasi -- Chapter 2: Aniseed, Shallot and Caraway -- Chapter 3: European Fill and Indian Dill -- Chapter 4: Poppy Seed.-Chapter 5: Star Anise and Japanese Star Anise -- Chapter 6: Sage -- Chapter 7: Savory and Tarragon -- Chapter 8: Thyme -- Chapter 9: Calamus or Sweet Flag -- Chapter 10: Horse Radish, Long Pepper or Pipli, Galangal -- Chapter 11:Quality Control.
    Abstract: This book is a compendium of rare and unique spices, which have been least researched but hold immense economic potential on a global scale. They are Aniseed, Shallot, Saffron, Caraway or Siah Zira, European or Indian Dill, Poppy, Star Anise and Japanese Star Anise, Sage, Savory, Tarragon, Thyme, Calamus or Sweet Flag, Horse Radish, Galangal, and Long Pepper or Pipli. Some of these are seed spices and others, like Saffron, are grown in the hills of Jammu and Srinagar, India and have varied uses, ranging from being very popular food flavorants to being used for religious purposes. Even within India, the country of the origin for most of the spices listed, many Indians are simply unaware of their immense economic potential. This is also the case with other countries, like Iran, where some spices, like Saffron, is widely used as a food flavorant. The book aims to be a unique compendium of these rare and unique spices to primarily enable researchers to tap into their great economic potential and, on a wider scale, help developmental agencies to tap into their immense potential in global spice trade. The book provides a cross-sectoral multi-scale assessment of developmental possibilities, globally, for rare and unique spices of immense economic importance. .
    Type of Medium: Online Resource
    Pages: IX, 141 p. 5 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031202490
    DDC: 641.3
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Food science. ; Food Analysis. ; Chemistry. ; Food Science. ; Food Analysis. ; Food Engineering. ; Food Chemistry.
    Description / Table of Contents: 1. Introduction -- 2. Forage quality vis-a vis livestock productivity -- 3. Forage Quality Indices -- 4. Forage quality components -- 5. Management of anti-nutrients in forages -- 6. General scheme for forage quality analysis -- 7. Laboratory essentials for forage evaluation -- 8. Solutions and buffers in estimations -- 9. Estimation of nutritional components in forages -- 10. Estimation of anti-quality and anti-nutritional factors in forages -- 11. Estimation of mineral content in forages -- 12. Estimation of phytochemicals and enzyme activities in forages -- 13. Quality Estimation of Natural Grasslands and Pastures. 14. Nutritional Quality of Important Forages -- 15. Conservation and processing of forages -- 16. Factors Affecting Forage Quality -- 17. Forage Nutritional Quality Management.
    Abstract: The book covers different techniques and methodologies involved in the nutritional quality analysis of forages. It also discusses the nutritional quality, anti-nutritional components, factors affecting forage quality, feed processing and conservation. Different techniques and methodologies have been presented in a simplified manner. The book has been divided in separate chapters and each chapter discusses different aspect of forage quality. Further, the book also covers the topics on conservation and processing of forages and management techniques for improving the forage nutritional quality. This book is an essential source of information for research scholars, post-graduate students and scientists working on forage quality estimation and also in livestock and dairy industries.
    Type of Medium: Online Resource
    Pages: XVII, 233 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811960208
    DDC: 641.3
    Language: English
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  • 32
    Keywords: Neurosciences. ; Cognitive neuroscience. ; Psychobiology. ; Human behavior. ; Sociology. ; Neuroscience. ; Cognitive Neuroscience. ; Behavioral Neuroscience. ; Sociology.
    Description / Table of Contents: Molecular imaging of the human emotion circuit -- The neurocognitive mechanisms of unconscious emotional responses -- Social and Affective Neuroscience of Embodiment -- The neuroscience of beauty -- Mirror Neurons … in action: ERPs and neuroimaging evidence -- Sex differences in social cognition -- Development of morality and emotional processing -- Trust in Social Interaction: From Dyads to Civilizations -- The time has come to be mindwanderful: Mind wandering and the intuitive psychology mode -- Social Cognition development and socio affective dysfunction in childhood and adolescence -- Clinical neuroscience meets second-person neuropsychiatry -- EEG and ERPs in the study of Language and Social Knowledge -- fMRI and fNIRS methods for social brain studies: hyperscanning possibilities -- Modulating the Social and Affective Brain with transcranial stimulation techniques -- What our eyes can tell us about our social and affective brain? -- Facial EMG – Investigating the interplay of facial muscles and emotions.
    Abstract: This Open Access book presents the current state of the art knowledge on social and affective neuroscience based on empirical findings. This volume is divided into several sections first guiding the reader through important theoretical topics within affective neuroscience, social neuroscience and moral emotions, and clinical neuroscience. Each chapter addresses everyday social interactions and various aspects of social interactions from a different angle taking the reader on a diverse journey. The last section of the book is of methodological nature. Basic information is presented for the reader to learn about common methodologies used in neuroscience alongside advanced input to deepen the understanding and usability of these methods in social and affective neuroscience for more experienced readers.
    Type of Medium: Online Resource
    Pages: XXXIII, 302 p. 55 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031086519
    DDC: 612.8
    Language: English
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  • 33
    Keywords: Biotic communities. ; Freshwater ecology. ; Marine ecology. ; Ecosystems. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Part (I) Introduction to river hazards and their management: Chapter 1. Natural River Hazards: Their Impacts and Mitigation Techniques -- Chapter 2. Assessment of sediment hazard and associated measurement -- Chapter 3. Modelling approach to study the riverine flood hazard of lower Damodar river -- Chapter 4. Field measurement of accumulated surface water and infiltration depth in a flood-prone Langol catchment of Manipur valley region -- Chapter 5. Soil erosion analysis with respect to land use / land cover change in Godavari basin -- Part (II) Stability of Hydraulic Structures and Sediment Transport: Chapter 6. Stability of hydraulic structures against erosion and scour due to water jets -- Chapter 7. Stabilization of Manmade Embankments at Indian Sundarban Estuary through Turbulence Control at Flow-Sediment Interface: Field Survey and Flume Experimentation -- Chapter 8. A Review of Sedimentation on Different Types of Weirs -- Chapter 9. A Review on Parametric Studies of Piano Key Weir -- Chapter 10 Influence of boundary condition on the modified 2D shallow water model near the flow-structure interaction zone: a case study in Brahmaputra River -- Chapter 11. A Review on Estimation Methods of Scour Depth around Bridge Pier -- Chapter 12. Estimation of Shear force Distribution in Two-stage open channel using SVM and ANFIS -- Chapter 13. Sediment transport modelling through machine learning methods: Review of current challenges and strategies -- Chapter 14. Impact of Anthropocene on the fluvial sediment supply: The Mahanadi River basin perspective -- Chapter 15. Assessment of sediment hazards by bed level variations around the bridge pier -- Chapter 16. Equation development for equilibrium bed load -- Part (III) Hydrological hazards and ecological restoration: Chapter 17. Flood mitigation with river restoration using Porcupine systems -- Chapter 18. Flood prioritisation of basins based on geomorphometric properties using Morphometric analysis and Principal component analysis: A case study of the Maner River basin -- Chapter 19. Flood modelling of Krishna river at Sangli using HEC-RAS -- Chapter 20. Development of Machine Learning based Flood Prediction Model for Godavari River Basin -- Chapter 21. Field study on soil organic matter content in inundation areas of Langol catchment by loss- on-ignition” method -- Chapter 22. Agricultural Drought Assessment using Satellite based Surface Soil Moisture Estimate -- Chapter 23. A Review on Hydrodynamics of Vegetated Streams -- Chapter 24. Analysis of Stormwater Drainage Network of the Central Zone in the Surat City by Using SWMM 5.1 Software -- Chapter 25. Review of state-of-the-art research on river hydrological hazards, restoration and management -- Chapter 26. Erosion Susceptibility Mapping based on Hypsometric Analysis using Remote Sensing and Geographical Information System Techniques -- Part (IV) Climate change and Global warming issues: Chapter 27. Climate Change Implication and Adaptation for River systems -- Chapter 28. Non-parametric approaches to identify rainfall pattern in semi-arid regions: Ranipet, Vellore, and Tirupathur districts, Tamil Nadu, India -- Chapter 29. Decadal-based analysis of hydrological components in the Kesinga sub-catchment in Mahanadi Basin: An assessment of climate variability impact -- Chapter 30. Prediction of Future Rainfall in the Upper Godavari Basin Using Statistical Downscaling Model -- Chapter 31. Projecting Future Maximum Temperature Changes in River Ganges Basin using Observations and Statistical Downscaling Model (SDSM) -- Chapter 32. Trend Assessment of Rainfall over Mumbai and Pune Cities -- Chapter 33. Evaluation of Potential lakes Susceptible to GLOF using Multi-Criteria Assessment in Jhelum Sub-basin of Indus Basin.
    Abstract: This edited book covers all aspects of River related disasters, challenges, and opportunities. Step-by-step descriptions are provided of river dynamics and associated hazards, and their applications in hazard assessments, accompanied by several experimental, filed and numerical studies. In addition, a systematic table of content is given to aid in identifying River hazards challenges and opportunities. Essential information is provided on River dynamics, hydrological processes and climate change issues, and an individual chapter is devoted to ecological restoration and river hazard management. Further topics include the stability of hydraulic structures, sediment transport, and debris flow in the hilly streams. This book will provide students, researchers, scientists, water resources managers with a comprehensive overview of the River dynamics and flood hazards in various sectors of water-related disasters and will enable them to explore the scope of application of the computational techniques and will enable them to explore the scope of River related disasters, allied branches and their field-specific problems. Professionals and policymakers may also explore the implementation of these approaches in their workplace to tackle complex river dynamics and hydrological phenomena occurring in their study area.
    Type of Medium: Online Resource
    Pages: X, 624 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811971006
    Series Statement: Disaster Resilience and Green Growth,
    DDC: 577
    Language: English
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    Keywords: Food science. ; Chemistry. ; Food Science. ; Chemistry.
    Description / Table of Contents: Section 1: Introduction -- 1. Introduction: Career Preparation for the Food & Beverage Industry -- 2. The Equilibrium of Life-Career Planning -- 3. First Jobs for Food Science -- Section 2: The undergraduate student experience -- 4. Making the Most of Your Undergraduate Experience -- 5. Campus Career Services and Centers -- 6. Professionalism and Leadership -- 7. Is Food Science Right For Me? The Transfer Experience -- 8. The Decision to Pursue an Internship -- 9. IFT Student Association -- Section 3: A successful industry career -- 10. Finding and negotiating a job -- 11. Employer expectations/Managing corporate life -- 12. Could a small company be for you? -- 13. A successful industry career or Making your way in a company -- Section 4: Careers with a degree in food science -- 14. Quality -- 15. Production management -- 16. Product development -- 17. Technical sales -- 18. R&D -- 19. Regulatory and food law -- 20. Careers in Traceability -- 21. Using food science in special interest groups -- 22. Food for Good: Leveraging Food Science to Feed the World -- 23. Careers that combine Culinary and Food Science -- 24. Entrepreneurship and Consulting: Taking a Different Path -- 25. Careers in Sensory Science -- 26. Food Science in Community-Based Food Systems -- 27. Working for a Startup Company -- 28. Careers in Sustainability -- 29. A Career in Management -- Section 5: The graduate student experience -- 30. Is grad school right for me? -- 31. Finding and getting into the right grad program -- 32. The transition from undergraduate to graduate student -- 33. Faculty expectations of graduate students.
    Abstract: Careers in Food Science provides detailed guidelines for students and new employees in the food industry to ensure a successful start to their career. Every step towards a rewarding career in this rapidly evolving industry is covered, from which classes to take in college and which degrees to earn, to internships, and finally how to land, and keep, the first job. This book also provides day-to-day examples of what to expect from the many jobs available to help students decide what to do and where to go. This second edition includes nine new chapters covering research chefs, food systems, social justice, food waste, start-ups, sustainability, and management. Several new authors offer fresh perspectives. Provides detailed guidelines for students as well as new employees in food industry; Includes perspectives from school years through how to succeed at new job; Written by individuals who have just gone through that experience or who are working in that particular sector.
    Type of Medium: Online Resource
    Pages: XII, 411 p. 5 illus., 1 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031143533
    DDC: 641.3
    Language: English
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  • 35
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Metabolism Disorders. ; Genetics. ; Cardiovascular system. ; Physiology. ; Biomedical Research. ; Metabolic Disease. ; Genetics and Genomics. ; Cardiovascular Physiology.
    Description / Table of Contents: An overview of genome editing in cardiovascular and metabolic diseases -- Bioinformatics research methodology of genome editing in cardiovascular and metabolic diseases -- Online databases of genome editing in cardiovascular and metabolic diseases -- Application of systems biology for genome editing involved in regulating of cardiovascular and metabolic diseases -- Bioinformatics for reducing off-targets in cardiovascular and metabolic diseases -- Genome editing and cardiac regeneration -- Genome editing and myocardial development -- Genome editing and heart failure -- Genome editing and pathological cardiac hypertrophy -- Genome editing and cardiac remodeling -- Genome editing and diabetic cardiomyopathy -- Genome editing and cardiac arrhythmias -- Genome editing and atrial fibrillation -- Genome editing and muscle atrophy -- Genome editing and obesity -- Genome editing and fatty liver -- Genome editing and diabetes -- Genome editing and gout -- Genome editing and protein energy malnutrition -- Genome therapy and cardiovascular diseases -- Therapeutics in metabolic diseases -- Gene editing and human iPSCs in cardiovascular and editing diseases -- Prospective advances in genome editing investigation.
    Abstract: This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing. Genome editing is a genetic engineering technique precisely modified specific target genes of organism genome, which has been applied to basic theoretical research and production applications from plants and animals to gene therapy of human beings. Cardiovascular and metabolic diseases have become major factors affecting human health worldwide. This book contains information about bioinformatics, genome editing in cardiovascular diseases, genome editing in metabolic diseases and therapeutic effects. It will be useful for biologist, cardiologist, cardiovascular surgeons, endocrinologist, internists, nurses, undergraduate and graduate students in medicine and cell biology and others interested in cardiovascular and metabolic medicine.
    Type of Medium: Online Resource
    Pages: XII, 339 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811956423
    Series Statement: Advances in Experimental Medicine and Biology, 1396
    DDC: 610.72
    Language: English
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  • 36
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Nanobiotechnology. ; Biomedical engineering. ; Nanotechnology. ; Medical care. ; Materials. ; Detectors. ; Nanobiotechnology. ; Biomedical Engineering and Bioengineering. ; Nanotechnology. ; Health Care. ; Sensors and biosensors.
    Description / Table of Contents: 1.Recent development in detection systems for human viral pathogens from clinical samples with special reference to biosensors -- 2. Nano Biosensors For COVID – 19 -- 3. Electrochemical detection of cancer fingerprint: A systematic review on recent progress in extracellular vesicle research from lab to market -- 4. Nano-biosensors for diagnosing infectious and lifestyle-related disease of human: an update -- 5. Design and Analysis of One Dimensional Photonic Crystal Biosensor Device for Identification of Cancerous Cells -- 6. Smart nanobiosensing for COVID-19 diagnosis -- 7. Machine Learning-Enabled Biosensors in Clinical Decision Making -- 8. Recent Progress on the Development of Chemosensors -- 9. Medical Device & Equipment Sector in India: Towards Sophisticated Digital Healthcare Systems - An Overview -- 10. Application of Radio Pharmaceuticals in Diagnostics and Therapy.
    Abstract: This book reviews the potential of next-generation point-of-care diagnosis in healthcare. It also discusses the printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection. The book presents the development of sensory systems based on the use of nanomaterials. It examines different biosensors for medical diagnosis using surface modification strategies of transducers. It presents electrochemical concepts based on different nanobiomaterials and nanocomposites for cancer theranostics. Notably, the book examines the recent advances in wearable, cost-effective hemodynamic sensors to detect diseases at an early stage. It further explores the combination of redox cycling and electrochemical detection to develop ultrasensitive and reproducible biosensors for point-of-care testing. Finally, the book summarizes the significant challenges in the point of care diagnostics and its future opportunities in healthcare. .
    Type of Medium: Online Resource
    Pages: IX, 249 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811971303
    DDC: 620.5
    Language: English
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  • 37
    Keywords: Forestry. ; Nanotechnology. ; Botany. ; Biotechnology. ; Anatomy. ; Genetics. ; Forestry. ; Nanotechnology. ; Plant Science. ; Biotechnology. ; Anatomy. ; Genetics and Genomics.
    Description / Table of Contents: Preface -- Chapter. 1. Emerging nanomaterials for forestry and associated sectors: An overview -- Chapter. 2. Potential of Nanomaterials in Bio-Based Wood Adhesives: An Overview -- Chapter. 3. Nanomaterials to improve fire properties in wood and wood-based composite panels -- Chapter. 4. Wood Plastic Composites (WPC): Applications of Nanomaterials -- Chapter. 5. Nanomaterials to improve properties in wood-based composite panels -- Chapter. 6. Nanomaterials to improve the strength of wooden joints -- Chapter. 7. Application of nanomaterials for wood protection -- Chapter. 8. Nanocellulose in paper and board coating -- Chapter. 9. Green Materials for Radiation Shielding: An overview -- Chapter. 10. Formaldehyde emissions from wood-based composites: Effects of nanomaterials.
    Abstract: Bio-based materials, including those containing wood, will become increasingly important as we move to a bio-based economy. Among their many attributes, it is vitally important that these materials are renewable, sustainable with proper management and environmentally benign. Wood remains one of our most important bio-based materials. While it is an amazing material, wood still has negative attributes and drawbacks that can affect performance, including dimensional instability when wetted, vulnerability to fire and high temperatures, and susceptibility to biodeterioration. A variety of treatments have been developed to overcome these weaknesses. Among the most exciting of these treatments are nanomaterials. These materials have some exceptionally attractive properties for improving timber performance and have been the subject of intensive research over the past decade. There is a tremendous need for a single comprehensive source of information on this rapidly emerging subject with tremendous potential to enhance the performance of a variety of bio-based materials. This book contains 10 chapters, each compiled by different author(s) who are considered the top researcher(s) in their respective fields. The chapters begin with some basic background on nanomaterials and their synthesis, then explore different areas for potential applications and conclude with a review of the emerging questions about nanomaterial safety. The book is designed to provide the latest information and know-how on application and utilization of different nanomaterials to improve the properties of wood and wood-based composite panels. The contents cover some main topics in the industry including improving physical and mechanical properties, increasing resistance to biodegradation (including fungi and insects), developing wood-plastic composites (WPC), applying nanomaterials in paper and board industry, and emergence of transparent wood and radiation shielding. It also covers the use of nanomaterials to improve the performance of paints and finishes used for forest products. The book provides a single location for those interested in the field to begin.
    Type of Medium: Online Resource
    Pages: X, 362 p. 85 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031173783
    DDC: 634.9
    Language: English
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  • 38
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Microbiology. ; Plant diseases. ; Microbial genetics. ; Plant physiology. ; Fungi. ; Mycology. ; Plants. ; Microbiology. ; Plant Pathology. ; Microbial Genetics. ; Plant Physiology. ; Fungi. ; Plant Signalling.
    Description / Table of Contents: Part I. Pathogenic Fungus – Plant Interactions -- Modulation of Host Immunity and Development by Ustilago Maydis -- RNA Dialogues in Fungal-Plant Relationships -- The Role of Tox Effector Proteins in the Parastagonospora Nodorum-Wheat Interaction -- Part II. Mutualistic Fungus – Plant Interactions -- Genomes of Arbuscular Mycorrhizal Fungi -- Diversity of Seed Endophytes: Causes and Implications -- Lichens and Their Allies Past and Present -- Lichen Fungal Secondary Metabolites: Progress in the Genomic Era Towards Ecological Roles in the Interaction -- Part III. Sensing and Signalling in Fungus-Plant Interactions -- Regulation of Plant Infection Processes by MAP Kinase Pathways in Ascomycetous Pathogens -- Role of pH in the Control of Fungal MAPK Signalling and Pathogenicity -- Role of Volatile Organic Compounds in Establishment of the Trichoderma-Plant Interaction -- Part IV. Regulation of Fungal Gene Expression and Development -- Epigenetic Regulation of Fungal Genes Involved in Plant Colonization -- Toward Understanding the Role of Chromatin in Secondary Metabolite Gene Regulation in the Rice Pathogen Fusarium Fujikuroi -- The Rice Blast Fungus Magnaporthe Oryzae Uses a Turgor-Dependent, Septin-Mediated Mechanism to Invade Rice -- Role of Light in the Life Cycle of Botrytis Cinerea -- Part V. Genomes and Evolution -- Species of Zymoseptoria (Dothideomycetes) as a Model System to Study Plant Pathogen Genome Evolution -- Accessory Chromosomes of the Fusarium Oxysporum Species Complex and Their Contribution to Host Niche Adaptation -- Part VI. Global Pandemics and Food Security -- Global Landscape of Rust Epidemics by Puccinia Species: Current and Future Perspectives -- Magnaporthe oryzae and Its Pathotypes: A Potential Plant Pandemic Threat to Global Food Security.
    Abstract: This fully revised 3rd edition provides a comprehensive overview of the biology of fungi associated with plants. Since the publication of the 2nd Edition in 2009, tremendous new knowledge has been gained in the field of fungal-plant interactions, which is reflected in the contributions of this book. World-leading scientists in the field provide authoritative insights into fungal-plant interactions covering the following main topics: Mutualistic and pathogenic fungal-plant interactions in natural and agricultural ecosystems Sensing and signalling in fungus-plant interactions Regulation of fungal gene expression and development Fungal genomes and evolution Global pandemics caused by fungal pathogens and their implications for food security This volume will be of great interest to both specialists and generalists. It is an indispensable resource for researchers, lecturers and students in microbiology, mycology, and plant sciences, as well as agriculture and biotechnology.
    Type of Medium: Online Resource
    Pages: XXII, 462 p. 70 illus., 62 illus. in color. , online resource.
    Edition: 3rd ed. 2023.
    ISBN: 9783031165030
    Series Statement: The Mycota, A Comprehensive Treatise on Fungi as Experimental Systems for Basic and Applied Research, 5
    DDC: 579
    Language: English
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  • 39
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Molecular biology. ; Cytology. ; Genetics. ; Virology. ; Cancer. ; Enzymology. ; Molecular Biology. ; Cell Biology. ; Genetics. ; Virology. ; Cancer Biology. ; Enzymology.
    Description / Table of Contents: Introduction -- The major processes in the biological world -- Enzymes, conformational changes, energy, and molecular motors -- The cells -- Genome -- Regulation of gene expression and protein activity -- DNA replication, its fidelity, mutations, and repair -- Transduction of signals -- Multicellular organisms and their development -- Biological defense I. Protection from foreign nucleic acids -- Biological defense II. The immune system of vertebrates -- Pathogens -- Cancer -- Index.
    Abstract: Accessible and comprehensive, this book describes the universal cellular nature of living organisms and is an indispensable tool for anyone in the sciences who wishes to get a quick overview of molecular biology. Individual chapters cover nucleic acids and proteins, genetic code and protein synthesis, the fidelity of transferring genetic information to the next generations, and the regulation of various processes inside the cells. Special attention is paid to new areas rising from modern DNA sequencing technologies which transform biology. The book also touches on developing areas, such as cures for cancer and CRISPR, which are important for medicine and the future of humankind. .
    Type of Medium: Online Resource
    Pages: XIV, 184 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031194047
    DDC: 572
    Language: English
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  • 40
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Blood-vessels Growth. ; Cytology. ; Clinical biochemistry. ; Angiogenesis. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Fibronectin Fibrillogenesis during Angiogenesis -- Chapter 2: Functional Interplay Between Fibronectin and Matricellular Proteins in the Control of Endothelial Tubulogenesis -- Chapter 3: Endothelial Cell-Matrix Interactions in Angiogenesis and Vessel Homeostasis: A Focus on Laminins and Their Integrin Receptors -- Chapter 4: Collagens and collagen-degrading enzymes in the regulation of angiogenesis -- Chapter 5: Kruppel-like factor 2 and matrix metalloproteinases in the context of vasculature -- Chapter 6: Extracellular Matrix-Remodeling Enzymes as Targets for Natural Antiangiogenic Compounds -- Chapter 7: Cell - extracellular matrix adhesions in vascular endothelium -- Chapter 8: Hypoxia: a potent regulator of angiogenesis through extracellular matrix remodeling -- Chapter 9: Leading roles of heparan sulfate in angiogenesis and cancer -- Chapter 10: The role of pericytes in tumor angiogenesis -- Chapter 11: Lymphatic Mechanoregulation in Development and Disease.
    Abstract: In the vasculature, the extracellular matrix (ECM) is involved in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability. This book aims to provide the reader with an overview of the various roles of the ECM during angiogenesis and covers its important role for the maintenance of vascular integrity, capillary and arterial morphogenesis, as well as lymphangiogenesis. Furthermore, aspects of regulation of endothelial cell and pericyte functions by the ECM under physiological and pathological conditions are discussed. In addition, the reader will learn more about different approaches to exploit ECM molecules for designing therapeutic approaches or as biomarkers to improve therapeutic decisions. Comprehensive and cutting-edge, Matrix Pathobiology and Angiogenesis is a valuable resource for experienced researchers and early career scientist alike, who are interested in in learning more about this exciting and developing field. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: XXVII, 320 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031196164
    Series Statement: Biology of Extracellular Matrix, 12
    DDC: 571.8
    Language: English
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  • 41
    Keywords: Agriculture. ; Environment. ; Plant genetics. ; Agriculture. ; Environmental Sciences. ; Plant Genetics.
    Description / Table of Contents: Chapter 1 Advances in research trends in vegetables under a changing climate: A way forward -- Chapter 2 Emerging obstacles of vegetable production due to climate change and mitigation strategies -- Chapter 3 Impact of climate change on nutraceutical properties of vegetables -- Chapter 4 Nutritional stress management in vegetable crops under changing climate scenario -- Chapter 5 Impact of climate change on tuber crops production and mitigation strategies -- Chapter 6 Impact of climate change on leafy vegetables and mitigation strategies -- Chapter 7 Impact of climate change on perennial vegetable production and mitigation strategies -- Chapter 8 Impact of climate change on vegetables seed production and mitigation strategies -- Chapter 9 Protected cultivation of high-value vegetables crop under changing climate -- Chapter 10 Impact of climate change on underexploited vegetable crops production and mitigation strategies -- Chapter 11 Improvement of vegetables through grafting techniques in changing climate scenario -- Chapter 12 Improvement of vegetables through molecular breeding in changing climate scenario -- Chapter 13 Kitchen gardening for nutritional security under changing climate -- Chapter 14 Emerging insect-pests of vegetables due to changing climate -- Chapter 15 Emerging diseases of vegetables due to changing climate -- Chapter 16 Impact of climate change on postharvest quality of vegetables.
    Abstract: This second volume on the topic will be extremely useful for the researchers and postgraduate students working on vegetable crops with a special focus on climate change. Today, the entire world is suffering from global warming and its consequent, climate change. This has emerged as the most prominent global environmental issue and there is an urgent need to mitigate its impact on agriculture. Over the past 20 years South Asia has had a robust economic growth, yet it is home to more than one fourth of the world’s hunger and 40% of the world’s malnourished children and women. Persistent climatic variability, which results in frequent drought and flood, is among the major reasons for this phenomenon. Vegetables are in general more succulent (have 90% water) and more sensitive to climatic vagaries and sudden changes in temperature, as well as irregular precipitation at any phase of crop growing, can affect the normal growth, flowering, pollination, fruit setting, fruit development and fruit ripening which eventually decreases the yield. The irregular precipitation also causes the soil salinity and is a major challenge in many vegetable growing areas. To mitigate the harmful impact of climatic change there is an urgent need to develop adequate adaptation strategies for adverse effect of climate change and preference should be given to the development of heat, cold, drought, flood and salinity stress tolerant genotypes along with climate proofing through conventional and non-conventional breeding techniques, as well as exploiting the beneficial effects of CO2 enhancement on crop growth and yield. Available evidence shows that there is high probability of increase in the frequency and intensity of climate related natural hazards due to climate change and hence increase the potential threat due to climate change related natural disasters in the world. At present protected cultivation and grafted seedlings are also popularizing among vegetable growers because of the huge scope as well as, molecular breeding, emerging insect-pests & diseases and postharvest quality of vegetables under this climate change scenario. Moreover, underexploited vegetables, perennial vegetable and tuber crops have a more tolerant ability to climate vagaries compare to major vegetables which are also discussed in this book.
    Type of Medium: Online Resource
    Pages: XVII, 369 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031208409
    Series Statement: Advances in Olericulture,
    DDC: 630
    Language: English
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  • 42
    Keywords: Forestry. ; Environmental management. ; Geographic information systems. ; Sustainability. ; Forestry. ; Environmental Management. ; Geographical Information System. ; Sustainability.
    Abstract: Andean dry forest ecosystems are threatened by deforestation and unsustainable land use methods. The negative effects for the livelihood of the local population, biodiversity, and the regional climate could be countered by reforestation measures; however, dry land forests have not attracted the same level of interest and investment like other ecosystems. This book describes the development of a priority-zone map for reforestation measures, showing where reforestation might have the greatest social and ecological benefits. To achieve this, a problem analysis of a case study region is conducted and thematic reforestation benefits are determined. Using remote sensing and GIS, the areas where benefits can be obtained are mapped in individual layers and compiled into a summarizing priority-zone map. It is thus possible to identify areas where reforestation would achieve multiple benefits. The concept of priority maps could be used to facilitate reforestation strategies by local communities and municipal governments and could thus contribute to initiate an integrated forest and landscape restoration of the Bolivian montane dry forests.
    Type of Medium: Online Resource
    Pages: XVII, 97 p. 42 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031203756
    Series Statement: SpringerBriefs in Geography,
    DDC: 634.9
    Language: English
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  • 43
    Keywords: Pharmacy. ; Pharmacology. ; Medical sciences. ; Drug development. ; Pharmaceutical chemistry. ; Toxicology. ; Pharmacovigilance. ; Pharmacy. ; Pharmacology. ; Preclinical Research. ; Pharmaceutics. ; Toxicology. ; Drug Safety and Pharmacovigilance.
    Description / Table of Contents: Chapter 1. Introduction to Calibration -- Chapter 2. Errors and Uncertainties in Calibrations -- Chapter 3. Calibration Methods and Procedures -- Chapter 4. Calibration Software Support -- Chapter 5. Objectives of Qualification -- Chapter 6. Approach to the Qualification process -- Chapter 7. Objectives, Methods and Roles of Verification -- Chapter 8. Improvement in Software Quality -- Chapter 9. General Principles of Validation -- Chapter 10. Process Validation and its Types -- Chapter 11. Pharmaceutical Equipment Validation -- Chapter 12. Cleaning Validation for the Pharmaceutical, Biopharmaceutical, Nutraceuticals -- Chapter 13. Validation of Pharmaceutical Dosages Form – Validation of Tablets, Capsules, Liquids and Semisolids -- Chapter 14. Approach for Herbal Standardization -- Chapter 15. Regulatory requirements for herbal medicines in India -- Chapter 16. Expert Opinion on the Basis of the Content.
    Abstract: This up-to-date and unique monograph covers the different aspects of pharmaceutical validation, calibration, qualification and documentation. It discusses the various methods and processes under all these heads. It includes eight major sections and exhaustively covers each topic.The book includes interesting and timely topics like the ‘Validation of herbals’ considering the increasing reliance on herbal medicines. It includes a section of validation of dosage forms, which is an essential topic for any pharmaceutical scientist. The chapters provide lucid illustrations, figures, flowcharts and other diagrams to facilitate understanding. A final section on 'expert opinion' provides a rundown about the global scenario to the readers. The book serves as a complete reference material for students, researchers and industry experts in the field of pharmaceutical sciences, medicinal chemistry and pharmacology.
    Type of Medium: Online Resource
    Pages: XX, 215 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811990021
    DDC: 615.1
    Language: English
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  • 44
    Keywords: Virology. ; Medicine Research. ; Biology Research. ; Life sciences. ; Virology. ; Biomedical Research. ; Life Sciences.
    Description / Table of Contents: 1. The Quest for Excellence and the Challenge of Gender Equality in Arbovirology: A Celebration of Women’s Contributions to the Field -- 2. Serendipity and Arboviruses -- 3. The Tapestry of Life: Weaving an Arbovirologist -- 4. Arbovirus and Viral Hemorrhagic Fevers Research Inception in Central and West Africa -- 5. From Bwamba to the Present: The Changing Forest of Arbovirology -- 6. Fighting Dengue, Chikungunya and Japanese Encephalitis -- 7. Chronicles of Hantaviruses: Foundations of Epidemiology and Ecology -- 8. Yellow Fever and Other Viruses in West Africa -- 9. The “Golden Age” of Arbovirology, 1950-1969 -- 10. Twenty-Seven Years of Field Studies on Dengue and Aedes Aegypti in Latin America -- 11. 50 Years of Medical Entomology: Miscellaneous Interesting Findings -- 12. Remembrances of Virology Past -- 13. An Overview of Arbovirology in São Paulo State, Southeastern Brazil: Highlighting the Virus Research Center in Ribeirão Preto City -- 14. An Unplanned Career in Arbovirology.
    Abstract: These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.
    Type of Medium: Online Resource
    Pages: XX, 542 p. 258 illus., 200 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031219993
    DDC: 579.2
    Language: English
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  • 45
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Plant diseases. ; Ecology . ; Agriculture. ; Botany. ; Plant Pathology. ; Ecology. ; Agriculture. ; Plant Science.
    Description / Table of Contents: 1. Historic Plant Disease Epidemics -- 2. Epidemic Factors -- 3. Predicting Variables. 4.Criteria to Develop Forecast -- 5. Modeling of Epidemic Dynamic -- 6. Decision Support Systems (DSSs) -- 7. Expert System -- 8. Geographic Information Systems: Web-Based Disease Forecasting -- 9. Decision Support Systems and Expert Systems: A Comparison -- 10. Forecasting in Changed Climate -- 11. Disease Detection: Imaging Technology and Remote Sensing -- 12. Classical Disease Forecasting Systems.
    Abstract: This book focus on creating popularity and interest in modeling, derivation of equations for plant disease forecasting or construction and use of Web-based Expert Systems among plant pathologists. This book covers descriptions of many historic plant disease epidemics, various forecasting systems and methods of their construction, instruments required for study of plant disease epidemics, widely used commercial forecasting systems and present global scenario of forecasting. In the human history plant disease epidemics have brought unsurmountable misery many a times. Still breaking out of epidemic in any time in any part of the world is a stark reality. The panic spraying of chemical pesticides is not a panacea. Only the IPM technology may give relief. This technology if backed by the disease forewarning system may yield the desired results. Hence, an in depth understanding of plant disease forecasting system and its successful implementation may bring the global food security. This title provides a useful background for all students, practitioners, and researchers interested in the field of epidemiology, food security and agriculture sciences. .
    Type of Medium: Online Resource
    Pages: XVIII, 126 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819912100
    DDC: 571.92
    Language: English
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  • 46
    Keywords: Biofilms. ; Microbial populations. ; Bacteria. ; Fungi. ; Mycology. ; Microbiology. ; Medical microbiology. ; Biofilms. ; Microbial Communities. ; Bacteria. ; Fungi. ; Medical Microbiology.
    Description / Table of Contents: 3M’s of Multi-Species Biofilms: Microbial Pathogens, Microenvironments and Minimalist Laboratory Approaches to Study Multi-Species Biofilms under Microenvironmental Conditions -- Methods for the visualization of multispecies biofilms -- In vitro, in vivo and ex vivo models to study mixed bacterial and fungal biofilms -- Current and emerging in vitro and in vivo biofilm models in investigating fungal-bacterial polymicrobial communities: Fungal-bacterial biofilm models -- Involvement of bacterial outer membrane vesicles in cell-cell interactions and their role in multi-species communities -- Polymicrobial biofilm models: the case of periodontal disease as an example -- Polymicrobial biofilms in cystic fibrosis lung infections: effects on antimicrobial susceptibility -- High resolution methods to study microbial interactions in biofilms -- Unity in Diversity: Interkingdom Polymicrobial Biofilms in Disease.
    Abstract: In an age of antibiotic resistant infections, the study of biofilms is increasingly important. Microbes more than often exist in complex multi-species or polymicrobial communities, making infections difficult to detect, diagnose and treat. Given the increased focus on studying biofilms in research and laboratory settings, particularly under conditions that closely mimic the clinical state, it is important to get an overview of the recent methods, model systems and tools being developed and employed in this context. This book offers readers the opportunity to learn more about current methods being used in the investigation of multi-species biofilms, both in vivo and in vitro. For this, the book highlights new technologies built and designed for the study of multiple species within biofilm communities, including those that can be leveraged for the evaluation of antimicrobial treatment approaches. The application of these state-of-the-art techniques to further our understanding of multi-species biofilms will be discussed and the reader will learn how the clinical microenvironment and the development of biofilm communities are considered when developing such tools. With cutting-edge contributions from experts in the respective domains, this book will benefit translational and basic research scientists, as well as clinicians, and is an informative resource for educators and their students. .
    Type of Medium: Online Resource
    Pages: VI, 321 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031153495
    Series Statement: Springer Series on Biofilms, 12
    DDC: 579.17
    Language: English
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  • 47
    Keywords: Stress (Physiology). ; Plants. ; Plant physiology. ; Botanical chemistry. ; Metabolism, Secondary. ; Plant Stress Responses. ; Plant Physiology. ; Plant Biochemistry. ; Plant Secondary Metabolism.
    Description / Table of Contents: Chapter 1:An Update on Reactive Oxygen Species Synthesis and its Potential Application -- Chapter 2 :Mechanism of Reactive Oxygen Species Regulation in Plants -- Chapter 3: Biomolecules Targeted by Reactive Oxygen Species -- Chapter 4: Functions of Reactive Oxygen Species in Improving Agriculture and Future Crop Safety -- Chapter 5: The Ecology of Reactive Oxygen Species Signaling -- Chapter 6: Physiological Impact of Reactive Oxygen Species on Leaf -- Chapter 7: Reactive Oxygen Species: Role in Senescence and Signal Transduction -- Chapter 8: Hazardous Phytotoxic Nature of Reactive Oxygen Species in Agriculture -- Chapter 9: Hormonal Response in Plants Influenced by Reactive Oxygen Species -- Chapter 10: The Dual Role of Reactive Oxygen Species as Signals that Influence Plant Stress Tolerance and Programmed Cell Death -- Chapter 11: ight into the Interaction of Strigolactones, Abscisic Acid, and Reactive Oxygen Species Signals -- Chapter 12: 12. Hydrogen Peroxide: Regulator of Plant Development and Abiotic Stress Response -- Chapter 13:Towards Sustainable Agriculture: Strategies Involving Phyto-Protectants against Reactive Oxygen Species -- chapter 14:Signaling Pathway of Reactive Oxygen Species in Crop Plants under Abiotic Stress -- Chapter 15: Adverse Impact of ROS on Nutrient Accumulation and Distribution in Plants.
    Abstract: This edited book focuses on ROS synthesis, potential applications, toxicity, and preservations. It explores the recently proposed hormonal response and biomolecules targeted in regulation of ROS. Chapters cover resistance and susceptibility to plant pathogen, strategies involving phytoprotectants, and life span of nematode affected by ROS. This book includes a compilation of recently written, integrated, and illustrated reviews describing latest information on ROS. Chapters incorporate both theoretical and practical aspects of plant ROS. Reactive oxygen species (ROS) are key signaling molecules involved in the redox equilibrium and biological processes. In plants, ROS play an important role in biotic and abiotic stress sensing, integration of diverse environmental signals, and commencement of stress-response networks, thus contributing to the establishment of defense mechanisms and plant resilience. Critical amount of ROS is required by plants for regular operation of vital physiological mechanisms. This book brings together a compilation of latest research work on reactive oxygen species and their emerging importance. The book is a useful read for students, researchers, and scientists in the field of agri-life sciences.
    Type of Medium: Online Resource
    Pages: XIII, 295 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811997945
    DDC: 581.788
    Language: English
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  • 48
    Keywords: Freshwater ecology. ; Marine ecology. ; Reproduction. ; Physiology. ; Pollution. ; Freshwater and Marine Ecology. ; Reproductive Physiology. ; Pollution.
    Description / Table of Contents: 1. Pesticide and xenobiotic metabolism in aquatic organisms -- 2. Endocrine disrupting activity of xenobiotics in aquatic animals -- 3. Water contamination through xenobiotics and their toxic effects on aquatic animals -- 4. Cypermethrin induced reproductive toxicity in zebrafish: biochemical and molecular perspective -- 5. Impact of Pesticides Application on Aquatic Environments And Biodiversity -- 6. Impact of microplastics on reproductive and physiological aspects of aquatic inhabitants -- 7. The Impact of Xenobiotics in Development & Reproduction of fresh water Fishes -- 8. Mixtures and Reproduction in Aquatic Organisms – benefits and challenges -- 9. Phytoestrogens as Endocrine-Disrupting Agents In Aquaculture -- 10. A Proteomic Approach to Studying the Effects of Xenobiotics on Aquatic Living Organisms -- 11. Role of Cytochrome P450 in xenobiotic metabolism in fishes -- 12. Pharmacokinetic-Pharmacodynamic modelling of Xenobiotics: Fate and effect in Aquatic Animals -- 13. Occurrence of xenoestrogen alkylphenols (Octylphenols and Nonylphenol), and its impact on the aquatic ecosystem -- 14. Xenobiotics' effect on fish reproduction and development -- 15. Scientometric analysis of ecotoxicological investigations of xenobiotics in aquatic animals -- 16. Toxic effects of nanomaterials on aquatic animals and their future prospective -- 17. Microplastic Contamination in Aquatic organisms: An Ecotoxicological perspective -- 18. Effect of xenobiotics and their degradation in aquatic life -- 19. Transcriptome analysis of aquatic species exposed to endocrine disruptors -- 20. Fundamentals of genotoxicity and antiparasitic drugs associated with genotoxicity in fish -- 21. Endocrine disrupting compounds (EDCs) as emerging aquatic contaminants: Emphasis on Reproduction and Development.
    Abstract: This book summarizes the latest understanding of the impact of xenobiotics on the developmental and reproductive processes of aquatic animals, particularly nektonic forms, which comprise an important group of aquatic ecosystems. Aquaculture is quickly becoming the largest contributor of fish protein for human consumption. As the aquaculture business expands, farmed fish will be exposed to more environmental toxins, necessitating the use of chemical therapeutic drugs for fish. This book brings together experts on the regulation of environmental toxins and food chemicals from around the world, as well as researchers looking into the metabolism and disposal of foreign chemicals (xenobiotics) in fish species. The impact of xenobiotics on reproductive and developmental biology of all living forms has become of prime importance at the current time. As the effect of these xenobiotics on aquatic animals is an emerging area for research and development, several groups across the world are working on these aspects, targeting different groups of fishes in both marine and freshwater ecosystems. This collective work highlights several key and updated recent aspects of different types of xenobiotics entering aquatic ecosystems, impacts of these agents on reproductive physiology, developmental biology, breeding biology, hormonal imbalance, aquatic ecology, and pollution on the aquatic ecosystem. The unique aggregation of different types of stressors to aquatic animals under a single volume will be a useful reference for readers, including scientists, teachers, students, researchers and policymakers and those involved in aquaculture and environment conservation.
    Type of Medium: Online Resource
    Pages: XXIX, 427 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819912148
    DDC: 577.6
    Language: English
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  • 49
    Keywords: Neurosciences. ; Neurology . ; Pharmacology. ; Neuroscience. ; Neurology. ; Pharmacology.
    Description / Table of Contents: Chapter 1: Why study Drug Resistant Epilepsy? -- Chapter 2: Pharmacoresistance in Epilepsy -- Chapter 3: Experimental models for the study of drug-resistant epilepsy -- Chapter 4: On Complexity and Emergence: Linking the Hypotheses of Pharmacoresistance in Epilepsy -- Chapter 5: Role of High-Frequency Oscillation Networks in Managing Pharmacoresistant Epilepsy -- Chapter 6: Transporter hypothesis in pharmacoresistant epilepsies. Is it at the central or peripheral level? -- Chapter 7: Changes in Targets as an Explanation for Drug Resistance in Epilepsy -- Chapter 8: Cellular and molecular mechanisms of neuroinflammation in drug-resistant epilepsy -- Chapter 9: Contribution of the antiepileptic drug administration regime to avoid the development and/or establishment of pharmacoresistant epilepsy -- Chapter 10: Pharmacogenetics in Epilepsy and Refractory Epilepsy -- Chapter 11: Seizures Induce Hypoxia or Hypoxia Induces Seizures. A Perverse Relationship that Increases the Risk of SUDEP -- Chapter 12: Neonatal excitotoxicity triggers degenerative processes related to seizure susceptibility and pharmacoresistance -- Chapter 13: Cerebrovascular remodeling and the role of vascular endothelial growth factor in the epileptic brain and pharmacoresistance -- Chapter 14: The Role of JNK3 in Epilepsy and Neurodegeneration -- Chapter 15: Application of proteomics in the study of molecular markers in epilepsy -- Chapter 16: GABAergic neurotransmission abnormalities in pharmacoresistant epilepsy: experimental and human studies -- Chapter 17: Genes involved in pharmacoresistant epilepsy -- Chapter 18: Drug-resistant Epilepsy and the Influence of Age, Gender and Comorbid Disorders -- Chapter 19: Indications for Intracerebral Recording in Candidates for Epilepsy Surgery -- Chapter 20: On the Development of New Drugs for the Treatment of Drug Resistant Epilepsy: An Update on Different Approaches to Different Hypotheses -- Chapter 21: Physical exercise as a strategy to reduce seizure susceptibility -- Chapter 22: Ketogenic Diet and Drug-resistant Epilepsy -- Chapter 23: Modulating P-glycoprotein Regulation as a Therapeutic Strategy for Pharmacoresistant Epilepsy -- Chapter 24: Vagus Nerve Stimulation for Intractable Seizures -- Chapter 25: Non Invasive Brain Stimulation as a potential Therapeutic Procedure in drug-resistant epilepsy -- Chapter 26: Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity.
    Abstract: This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.
    Type of Medium: Online Resource
    Pages: XV, 596 p. 84 illus., 79 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031365263
    DDC: 612.8
    Language: English
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  • 50
    Keywords: Nutrition   . ; Economic development. ; Ethnology Africa. ; Culture. ; Food security. ; Medical sciences. ; Nutrition. ; Development Studies. ; African Culture. ; Food Security. ; Health Sciences.
    Description / Table of Contents: Chapter 1. Introduction Changing Dietary Patterns, Indigenous Foods, and Wild Foods in Relation to Wealth, Mutual Relations, and Health in Tanzania -- Chapter 2. Environment, Dietary Patterns, and Combinations of Food Intake in Tanzania -- Chapter 3. Purchase, Cultivation, and Forage: Does it Make a Difference in Food Intake Frequency? -- Chapter 4. Does Staple Food Sufficiency Ensure Food Variety? A Comparative Analysis from Southern, Southeastern, and Central Tanzania -- Chapter 5. Changing Dietary Patterns and Associated Social Context Subjective Health Quality of Life, Wealth, and Mutual Relations in Tanzania -- Chapter 6.Social Capital and Subjective “Poverty” Contribute to People’s Subjective Health, but Financial Support Does Not -- Chapter 7. Growth with Disparity in a Rich Diverse City: Case of the Economic Capital Dar es Salaam -- Chapter 8. High Maize Productive Rural Inland Areas: Ample Staple Food, but What about Health? -- Chapter 9. Coastal Traditional and Changing Dietary Patterns: Protein from Fish and Pulses as well as Patterns of Purchased Food -- Chapter 10. Does Intake of Wild Foods Improve Subjective Health? Evidence from 3 Areas of Tanzania -- Chapter 11. Case of Inland Forest Vicinities in Tanzania: General Low Health Evaluation but Higher for Those Who Access Variety of Wild foods? -- Chapter 12. Traditional Semi-arid Agro-pastoral Inland Food Patterns and Society: Frequent Food Deficits but Balanced BMI and Prevention of Anemia -- Chapter 13. Nutrition Potential of African Wild Leafy Vegetables: Evidence from Semi-arid Central Tanzania -- Chapter 14. Conclusions What is the Secret to Good Health, and How are Wealth and Mutual Assistance Related?.
    Abstract: This book presents different dietary patterns, some utilizing wild foods and others facing drastically changing dietary patterns, and shows their implications for health in terms of wealth, mutual assistance, food sufficiency and food diversity. The book examines these globally important issues through a case study of Tanzania. Using a novel methodology based on a global standard quality of life indicator, the book sheds light on the relationship between wild food intake and health in Tanzania. Descriptive case studies illustrate the impact of various food patterns and wild food intake on human health. It also highlights the divergence between food production sufficiency and food diversity. It then discusses the influence of wealth, mutual relations, and methods of food access. Finally, the book concludes with recommendations for maintaining good health in various environments. The intended readers of this book are academics and professionals in the fields of development, nutrition, and environment in East Africa. These include, but are not limited to, regional and district personnel who are actively engaged in development, relevant ministries of food and agriculture, and international organizations such as FAO, UNICEF, UNDP, and UNEP. In the academic field, students and researchers in international studies, development studies, African studies, social studies, cultural studies, nutrition, agriculture, and environmental studies are targeted. .
    Type of Medium: Online Resource
    Pages: XXIX, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819933709
    DDC: 613.2
    Language: English
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  • 51
    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Pharmacology. ; Neuroscience. ; Psychiatry.
    Description / Table of Contents: Preface -- A Historic Review of the D3 Dopamine System from D3 Cloning to Clinical Trials in Schizophrenia and Drug Addiction -- Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System -- Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor-Receptor Interaction and Striatal Function -- Involvement of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity of the Emotional Brain Circuits: Possible Role in Depression -- Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target -- Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease -- Therapeutic Challenges of Cognitive Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3 Receptor -- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders -- The Role of D3 Dopamine-Receptors in Nicotine Dependence: A Synthesis of the Pre-Clinical and Clinical Literature -- The Dopamine D3 receptor in Food Addiction -- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of D3 Receptor Ligands in Schizophrenia -- D3 receptors and Restless Legs Syndrome -- D3 receptors and PET imaging.
    Abstract: The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor. The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.
    Type of Medium: Online Resource
    Pages: VIII, 275 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031230585
    Series Statement: Current Topics in Behavioral Neurosciences, 60
    DDC: 615
    Language: English
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  • 52
    Keywords: Medicine Research. ; Biology Research. ; Medical education. ; Anatomy. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Medical Education. ; Anatomy. ; Virtual and Augmented Reality.
    Description / Table of Contents: Chapter 1. Pandemic-Era Digital Education: Insights from an Undergraduate Medical Programme -- Chapter 2. Use of Lt Systems in Large Class Lab Delivery -- Chapter 3. COVID-19 Adaptations for Biomedical Teaching and Assessment Within the Undergraduate Dental Curriculum -- Chapter 4. One Size Does Not Fit All in Remote Anatomy Teaching -- Chapter 5. From Lecture Halls to Zoom Links: How Can Educational Theory Help Us to Deliver Effective and Engaging Teaching in an Online Environment? -- Chapter 6. Collaborative, Two-Directional Live Streaming to Deliver Hands-on Dissection Experience during the COVID-19 Lockdown -- Chapter 7. Livestreaming Can Augment the Observation of Veterinary Post-mortem Examinations -- Chapter 8. Virtual Reality for Anatomy and Surgical Teaching -- Chapter 9. Can Synchronous Online Near-Peer Teaching Offer the Same Benefits as the Face-to-Face Version When Used in Clinical Neuroanatomy Education? -- Chapter 10. COVID-19 Adaptations with Virtual Microscopy -- Chapter 11. The Challenges of Visualisation During Delivery and Assessment of Clinical Teaching Under COVID-19: A Reflective Account of Problem Solving -- Chapter 12. Not for Room 101.
    Abstract: This book focuses on the challenges to biomedical education posed by the lockdowns and restrictions to on campus teaching brought about by the COVID-19 pandemic and highlights the tools and digital visualization technologies that have been successfully developed and used for remote teaching. Biomedical education for science, medical, dental and allied health professionals relies on teaching visual and tactile knowledge using practice-based approaches. This has been delivered for decades via on-campus lectures, workshops and laboratories, teaching practical skills as well as fundamental knowledge and understanding. However, the arrival of the COVID-19 pandemic meant that education across the globe had to pivot very quickly to be able to deliver these skills and knowledge in a predominantly online environment. This brought with it many challenges, as Higher Education staff, had to adapt to deliver these visual subjects remotely. This book addresses the challenges and solutions faced by Higher Education staff in teaching visual content in distance education. Chapters include literature reviews, original research, and pedagogical reflections for a wide range of biomedical subjects, degrees such as medicine, dentistry and veterinary sciences with examples from undergraduate and postgraduate settings. The goal of the book is to provide a compendium of expertise based on evidence gathered during the COVID-19 pandemic, as well as reflections on the challenges and lessons learned from this dramatic shift in teaching. It also presents new examples of best practices that have emerged from this experience to ensure that they are not lost as we return to on-campus learning in a new era of biomedical teaching. This book will be of interest to anyone looking for a helpful reference point when designing online or blended teaching for visual practice-based subjects.
    Type of Medium: Online Resource
    Pages: X, 228 p. 56 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031171352
    Series Statement: Advances in Experimental Medicine and Biology, 1397
    DDC: 610.72
    Language: English
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  • 53
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Radiation dosimetry. ; Radiology. ; Radiography, Medical. ; Nuclear medicine. ; Radiation Dosimetry and Protection . ; Radiology. ; Radiography. ; Nuclear Medicine.
    Description / Table of Contents: Dose Optimization: A Useful Tool in Radiation Protection -- Digital Radiography: A Technical Review -- Optimization Strategies in Digital Radiography -- Computed Tomography: A Technical Review.
    Abstract: This book addresses radiation protection of patients having digital radiography and computed tomography (CT) examinations. The literature on radiation doses to patients from these two modalities have reported that the doses to patients are high. As a result, the radiology community has focused on methods and procedures to keep these doses as low as reasonably achievable (ALARA) without compromising the diagnostic image quality. This book outlines the motivation for dose optimization in radiology, identifies and describes the ICRP principle of optimization, outlines the factors affecting the dose in digital radiography and in CT, and identifies and describes strategies used in digital radiography and in CT for dose optimization. This book is intended for all those working in digital radiography and CT environments including radiological technologists, and radiographers, radiologists, biomedical engineering technologists, and student medical physicists. It is best used as a supplement to radiologic science textbooks, and in particular, radiation protection textbooks. Furthermore, this book lays the foundations for students and practitioners engaged in research on dose reduction and dose optimization in radiology.
    Type of Medium: Online Resource
    Pages: XIII, 102 p. 37 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031228711
    DDC: 571.45
    Language: English
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  • 54
    Keywords: Agriculture. ; Soil science. ; Microbial ecology. ; Agriculture. ; Soil Science. ; Microbial Ecology.
    Description / Table of Contents: Chapter 1 The perpetual battle of bacteria and phages -- Chapter 2 Orchestration of the plant microbiome for enhanced agriculture -- Chapter 3 Plant growth promoting rhizobacteria to mitigate biotic and abiotic stress in plants -- Chapter 4 Ecology and mechanisms of plant growth promoting rhizobacteria.-Chapter 5 Diversity and evolution of nitrogen fixing bacteria -- Chapter 6 Encapsulation of biofertilizers, biopesticides and biocontrol agents -- Chapter 7 Induced systematic resistance and plant immunity -- Chapter 8 Microbial elicitors for priming plant defense mechanisms -- Chapter 9 Microbial mitigation of abiotic stress in crops -- Chapter 10 Microbial alleviation of abiotic and biotic stresses in rice -- Chapter 11 Nutritional biofortification of crops by microbes -- Chapter 12 Microbial rejuvenation of soils for sustainable agriculture -- Chapter 13 Microbial remediation of agricultural residues -- Chapter 14 The biotechnological story of microbial genes from soil to transgenic plants -- Chapter 15 Microbial biosurfactants in the green agricultural technology -- Chapter 16 Role of microbes in the synthesis of industrial products from lignocellulosic materials.
    Abstract: In the context of rising adverse effects of climate change on agriculture, there is a need for advanced methods and practices to manage soils for production of food and energy. This book presents the latest advances in microbial processes that control plant growth, with focus on genomic tools, microbial interactions with the plant and soils habitats, mobilization of plant nutrients, agricultural waste management, biodegradation, bioremediation, carbon sequestration, land reclamation, plant growth promotion, suppression of plant pathogens, induced systemic resistance and tolerance against biotic and abiotic stresses.
    Type of Medium: Online Resource
    Pages: XV, 458 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031241819
    Series Statement: Sustainable Agriculture Reviews, 60
    DDC: 630
    Language: English
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  • 55
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Biomedical Research. ; Cell Biology.
    Description / Table of Contents: Chapter 1. Magnetic Field Parameters and Biological Sample Differences that Lead to Differential Bioeffects -- Chapter 2. Static Magnetic Field Direction-induced Differential Biological Effects -- Chapter 3. Magnetic Properties of Biological Samples -- Chapter 4. Molecular Mechanisms for Electromagnetic Field Biosensing -- Chapter 5. Controlling Cell Membrane Potential with Static Non-uniform Magnetic Fields -- Chapter 6. Impact of Static Magnetic Fields on Cells -- Chapter 7. Impact of Static Magnetic Fields on Microorganisms, Plants and Animals -- Chapter 8. Static Magnetic Fields on Human Bodies -- Chapter 9. Potential Applications of Static Magnetic Fields in Cancer Treatment -- Chapter 10. Effects of Static Magnetic Fields on Diabetes and Its Complications -- Chapter 11. Impacts of Static Magnetic Field on Bone Health -- Chapter 12. Effects of Static Magnetic Fields on the Immune System -- Chapter 13. Biological Effects of Static Magnetic Fields on the Nervous System -- Chapter 14. The Biological Effects of Long-term Static Magnetic Field Exposure -- Chapter 15. Prospects, Pitfalls, and Opportunities for Human Static Magnetic Field Therapy.
    Abstract: The book summarizes the emerging topic about the effects of SMF on biological samples ranging from single molecules, subcellular compartments, and cells to whole organisms. It also discusses the potential application of SMF in clinical treatment of cancer, pain, diabetes and other diseases. With the development and growing popularity of modern appliances like MRI in hospitals, the potential impact of magnetic fields on human health is invoking increasing concerns. At the same time, SMF has been explored in the treatment of tumor and other diseases for decades. Nevertheless, there are still some reservations and uncertainties about these treatments, which are largely due to the differential biological effects reported in the literature. These experimental inconsistencies are mainly caused by variations such as different magnetic field types, intensities, treatment time, as well as biological samples examined. The second edition added eight new chapters about new progress in this field including impacts of SMFs, magnetism of biomolecules, and potential of SMFs in the management of bone, pain, diabetes, and immune systems. This volume will help clarify some dilemmas in this field and encourage further investigations in order to achieve a better understanding of the biological effects of SMF, aiming for a rational application of SMF in clinical therapy in the near future. The book is useful for scientists, doctors, and students who are interested in magnetic fields and life sciences.
    Type of Medium: Online Resource
    Pages: XV, 420 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789811988691
    DDC: 610.72
    Language: English
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  • 56
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurology . ; Developmental neurobiology. ; Neuroscience. ; Neurology. ; Development of the Nervous System.
    Description / Table of Contents: The development of the cerebellum: from the beginnings -- Part I: Responsibilities and liabilities -- Chapter2. The embryology and anatomy of the cerebellum -- Chapter 3. Cellular and genetic programs underlying cerebellum development -- Chapter 4. Early Purkinje Cell Development and the Origins of Cerebellar Patterning. - Chapter 5. Development of the Fish Cerebellum. -Chapter 6. Cerebellar developmental disorders and cerebellar nuclei -- Chapter 7. Motor circuit abnormalities during cerebellar development -- Chapter8. Developmental disorders of the cerebellum and neurotrophic factors -- Chapter9. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development -- Chapter10. The ubiquitin proteasome system and cerebellar developmental disease -- Chapter11. Epigenetics and Cerebellar Neurodevelopmental Disorders -- Chapter12.. Hormonal regulation of cerebellar development and its disorders -- Chapter13. Infections of the Cerebellum -- Chapter14. Neuroimmune mechanisms of cerebellar development and its developmental disorders -- Chapter15. Teratogenic influences on cerebellar development -- Chapter16. Primary pediatric brain tumors of the posterior fossa -- Chapter17. Primary pediatric brain tumors of the posterior fossa -- Chapter18. Can cerebellar neurodevelopmental disorders affect behavioral disorders or vice versa -- Chapter19. Neurodevelopmental disorders of the cerebellum: autism spectrum disorder -- Chapter20. Congenital cerebellar disease -- Chapter21. Clinical features, assessment, and management of patients with developmental and other cerebellar disorders -- Chapter22. Epidemiology of cerebellar disorders -- Chapter23. Cerebellar transplantation: a potential model to study repair and development of neurons and circuits in the cerebellum. - Chapter 24. Non-coding RNAs and cerebellar development. - Chapter 25. Defining the Cerebellar Cytoarchitecture Using MRI. .
    Abstract: This updated reference covers diverse aspects of cerebellar development from a full range of viewpoints, including the epidemiology of cerebellar genetic disorders, developmental anatomy, cell biology, genetics, epigenetics, infectious diseases, and mechanisms involved in the regulation of cell fate, while also focusing on information that is relevant to clinicians caring for patients with cerebellar disorders. The chapters are written by experts in the field of cerebellar development, and the chapters cover diseases related to the cerebellum, along with their epidemiology, clinical features, assessment, and management. In addition to updating the content to cover the significant developments in the field since the first edition, the second edition will include new chapters on Non-Coding RNAs and Cerebellar Development, Development of the Fish Cerebellum, the Role of nNOS/NO on Cerebellar Development in Health and Disease, and rehabilitation in cerebellar ataxia. The effect of the COVID-19 on the cerebellum has been included in related chapters. Development of the Cerebellum from Molecular Aspects to Diseases, 2nd edition, is designed to be valuable reference for both neuroscientists and clinicians.
    Type of Medium: Online Resource
    Pages: IX, 639 p. 116 illus., 88 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031231049
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 57
    Keywords: Biotechnology. ; Sustainability. ; Biomaterials. ; Biotechnology. ; Sustainability. ; Biomaterials.
    Description / Table of Contents: Chapter 1_Biomass to liquid fuels: Recent trends in techniques in catalytic conversions -- Chapter 2_Towards sustainable production of hydrogen and biogas from biomass residues -- Chapter 3_ Biorefinery for biofuel production: A Case Study -- Chapter 4_Techno economic analysis and profitability analysis of biofuel production -- Chapter 5_Life cycle analysis and environmnetal impact of bio fuel production -- Chapter 6_Valorization of non lignocellulosic bio waste for BioChemicals -- Chapter 7_State of art technologies for production of biochemicals from biomass -- Chapter 8_Nutraceuticals functional foods and specialty chemicals -- Chapter 9_Technoeconomical analysis of BioChemical production: A Case study -- Chapter 10_Life cycle assessment and sustainability for production of pectin -- Chapter 11_Production of biofertilizers from agro residue: sustainability issues and challenges -- Chapter 12_Utilization of activated carbon obtained from biomass in waste water treatment -- Chapter 13_Sustanability and life cycle assessment of nano-materials from biomass -- Chapter 14_Biorefinery approach for production of enzymes from fruit peel waste -- Chapter 15_Production of Biomaterials: A Case study.
    Abstract: This book discusses recent trends and concepts in the field of biorefinery. It discusses optimal and economic strategies for converting biomass to value-added products to maximize profits with minimal environmental impact with a sustainability approach. The chapters of the book are focused on the current technologies, techno-economical aspects, life cycle assessment, and case studies. The book is divided into three sections; the first section presents strategies for the production of biofuels like bioethanol, biomethane, biohydrogen, bio-oil, gasification, etc., from the biomass in a sustainable way. The second sections review the extraction of bioactive chemicals, phenolic antioxidants, enzymes, and carboxylic acid from the biomass residue. The last section examines the utilization of biomass for the production of bioactive materials, including biofertilizers, bioadsorbents, activated carbon, nano-materials, and pigments. This book explores the relation between biofuels and the sustainable development goals (SDGs) 7.
    Type of Medium: Online Resource
    Pages: XII, 409 p. 56 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811974816
    DDC: 660.6
    Language: English
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  • 58
    Keywords: Agricultural biotechnology. ; Medicine Research. ; Biology Research. ; Materials. ; Detectors. ; Biomaterials. ; Agricultural Biotechnology. ; Biomedical Research. ; Sensors and biosensors. ; Biomaterials.
    Description / Table of Contents: Part – I Introduction -- Biomaterials and Biopolymers for the Development of Biosensors -- Part – II Development of nanomaterials and biocomposites as sensors -- Nanobiohybrid Materials for Development of Biosensors -- Biosynthesis, Biofunctionalization, and Bioapplications of Manganese Nanomaterials: An Overview -- Transducers in Biosensors -- Self-Assembly and Fabrication of Biomaterials onto Transducers and their Characterization -- Biocatalytic Sensors: Potentials, Maxims and Mechanisms for Optimal Performance -- Part – III Potential role and applications of bio-based sensors -- Polyhydroxyalkanoate-based sensors and their applications -- An Overview of Immunosensors and their Application -- Live Cells as Biosensors -- Part – IV Biomaterials-based sensors for agricultural and biomedical applications -- Magnetic Nanoparticles Based Novel Sensors for select biomedical/ biological science applications -- Electrochemical Biosensors in Agricultural and Veterinary Applications -- The Applications of Biosensors and Biochips for Prognosis and Diagnosis of Diseases.
    Abstract: With the recent technological advancement usage of unique nanomaterials and bio-based composite materials as sensors has been greatly improved. Biopolymers and bio-based composite materials have especially been exploited due to their unique physical, optical, electrochemical, and biocompatible properties. In this book, experts and researchers in various sensor technology areas discuss the basics of biosensors, the methods used to synthesize different biomaterials, and the characterization and functionalization of these biomaterials. Processes for the self-assembly of biomaterials and the fabrication of biomaterials onto transducers are clearly explained. It also outlines the current status in the field and the utility of such bio-based sensors for medical diagnostics, food safety, industrial, and environmental monitoring. Besides pressure and temperature sensing applications, other applications include detecting gases, chemicals, biomolecules, body fluids, bacteria, and viruses. The book is well illustrated, and the presentation is concise and systematic throughout. Biomaterials-Based Sensors will be an ideal source of up-to-date information for all engaged in their research, design, and use.
    Type of Medium: Online Resource
    Pages: XV, 411 p. 110 illus., 84 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811985010
    DDC: 630
    Language: English
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  • 59
    Online Resource
    Online Resource
    Wiesbaden :Springer Fachmedien Wiesbaden :
    Keywords: Epidemiology. ; Diseases. ; Virology. ; Epidemiology. ; Diseases. ; Virology.
    Abstract: This essential presents infectious diseases of humans and animals that occur or can become endemic in Germany and Europe. These include current threats, African swine fever, avian influenza and COVID-19. In addition, the biology of mosquitoes is described. Globalisation and global warming favour the establishment of new mosquito species that can transmit viruses of the tropics and subtropics, e.g. chikungunya, dengue and West Nile virus. The Schmallenberg virus, which is of veterinary relevance, shows how rapidly new pathogens are spreading in Europe. The content African swine fever Zoonoses: avian influenza, Borna disease and COVID-19 Mosquitoes Arboviruses of animals: Schmallenberg and bluetongue viruses Human arboviruses in Europe: Chikungunya, Dengue and West Nile viruses The target groups Persons with an interest in biological and biomedical topics and infectious diseases The authors Patric U. B. Vogel is a biologist and has worked with a variety of pathogenic bacteria and viruses. Among other things, he has taught a two-year virology/microbiology seminar, released vaccines as a Qualified Person, and is self-employed in the pharmaceutical field. Prof. Dr. Günter A. Schaub is a parasitologist and senior professor at the Ruhr-Universität Bochum. In the case of the Latin American Chagas disease, his research includes the interactions of the pathogen with the vectors as well as the distribution and vector biology of mosquitoes and ticks. This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
    Type of Medium: Online Resource
    Pages: VIII, 55 p. 13 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783658418267
    Series Statement: essentials,
    DDC: 614.4
    Language: English
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  • 60
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Virology. ; Pharmacology. ; Biology Technique. ; Internal medicine. ; Virology. ; Pharmacology. ; Biological Techniques. ; Internal Medicine.
    Description / Table of Contents: Chapter 1 Hepatitis E Virus -- Chapter 2 Characteristics and Functions of HEV Proteins -- Chapter 3 Epidemiology of Hepatitis E -- Chapter 4 Hepatitis E as a Zoonosis -- Chapter 5 Genetic Evolution of Hepatitis E Virus -- Chapter 6 Transmission of Hepatitis E Virus -- Chapter 7 Immunobiology and Host Response to HEV -- Chapter 8 Cell Culture for hepatitis E virus -- Chapter 9 Stem Cell and organoid culture for hepatitis E virus -- Chapter 10 Lifecycle of hepatitis E Virus -- Chapter 11 Morphogenesis of Hepatitis E Virus -- Chapter 12 Animal Models for Hepatitis E Virus -- Chapter 13 Clinical Manifestations of Hepatitis E -- Chapter 14 Laboratory Diagnosis of HEV Infection -- Chapter 15 Treatment of Hepatitis E -- Chapter 16 Prophylactic Hepatitis E Vaccine -- Chapter 17 Puzzles for hepatitis E virus.
    Abstract: This book systematically and comprehensively discusses the biological, epidemiological, and clinical characteristics of the hepatitis E virus (HEV). It presents current knowledge of HEV and explores experimental methods, treatment, and prevention of HEV. First identified in the 1980s and cloned in 1990, HEV is the causative agent of hepatitis E, which mainly occurs in developing regions, such as Southeast Asia, the Middle East, and Africa, and significantly affects the health of the people in these areas. It is estimated that a third of the world’s population has been infected with HEV, which is transmitted via the fecal-oral route and can infect both humans and animals. In the second edition, new chapters are added to demonstrate the lifecycle, morphogenesis, and stem cell culture of hepatitis E virus. Although research on hepatitis E virus has made progress recently, there are still some problems that have not been solved. Those problems are discussed in this edition, which would be helpful for researchers to understand the problems on hepatitis E virus that they have faced. Meanwhile, the epidemiology, transmission, genetic evolution, animal models, treatment, and others in the related chapters of the first version were also updated according to the most recent research progress. The book provides an overview of HEV from benchside to bedside. It is a valuable resource for researchers in the field and those in the pharmaceutical industry developing HEV vaccines, as well as physicians involved in identifying and treating those infected with the virus.
    Type of Medium: Online Resource
    Pages: XII, 256 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789819913046
    Series Statement: Advances in Experimental Medicine and Biology, 1417
    DDC: 579.2
    Language: English
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  • 61
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Genetics. ; Biotechnology. ; Plant Science. ; Genetics and Genomics. ; Biotechnology.
    Description / Table of Contents: Reference genome sequence of flax -- Repeat DNA sequences in flax genomes -- Pale flax (Linum bienne): an underexplored flax wild relative -- Flax breeding -- QTL mapping: strategy, progress and prospects in flax -- Genetics of abiotic stress in flax. QTL and candidate genes for flax disease resistance -- Key stages of flax bast fiber development through the prism of transcriptomics -- Metabolomics and transcriptomics-based tools for linseed improvement.
    Abstract: The Flax Genome is a comprehensive compilation of most recent studies focused on reference genome, genetic resources and molecular diversity, breeding, QTL mapping, gene editing tools, functional genomics and metabolomics, molecular breeding via genomic selection, and genomic resources. The flax genome reference sequences and the new genome assemblies are presented. A list of flax QTL and candidate genes associated with more than 35 traits, including yield and agronomic, seed quality and fatty acid composition, fibre quality and yield, abiotic stress, and disease resistance traits, are summarized. A QTL- based genomic selection strategy and genome–editing tools are systematically introduced. In addition, huge amounts of flax genomic resources generated in the last decade are summarized. The book contains 13 chapters with about 390 pages authored by globally reputed researchers in the relevant fields to this crop The book is intended to be useful to students, teachers, and researchers interested in traditional and molecular breeding, pathology, molecular genetics and breeding, bioinformatics and computational biology, and functional genomics.
    Type of Medium: Online Resource
    Pages: XII, 294 p. 74 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031160615
    Series Statement: Compendium of Plant Genomes,
    DDC: 580
    Language: English
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    Keywords: Microbiology. ; Agriculture. ; Ecology . ; Microbiology. ; Agriculture. ; Ecology.
    Description / Table of Contents: 1. Exploring Microbial Diversity of Arid Regions of Globe for Agricultural Sustainability: A Revisit -- 2. Harnessing drought tolerant PGPM in arid agro ecosystem for plant disease management and soil amelioration -- 3. Role of Plant Growth-promoting Bacteria in Rainfed and Irrigated Crops -- 4. Plant Growth Promoting Microbes: The Potential Phosphorus Solubilizers in Soils of Arid Agro-ecosystem -- 5. Diversity of PGPM and Ecosystem Services -- 6. Plant Growth Promoting Microorganisms: An Option for Drought and Salinity Management in Arid Agriculture -- 7. Plant Growth Promoting Microbes: Key Players in Organic Agriculture -- 8. Interceding Microbial Biofertilizers in Agroforestry System for Enhancing Productivity -- 9. Role of PGPM in Managing Soil Borne Plant Pathogens in Horticulture Crops -- 10. The Use of Plant Growth Promoting Microorganisms in the Managementof Soil-Borne Plant Pathogenic Organisms -- 11. Role of plant growth promoting microbes in managing soil-borne pathogens in forestry -- 12. Secondary Metabolites and Bioprospecting -- 13. PGPM: Fundamental, Bioformulation, Commercialization and Success at Farmer’s Field -- 14. PGPR: A Sustainable Agricultural Mitigator For Stressed Agro-Environments -- 15. Endophytic PGPM derived metabolites and their role in arid ecosystem -- 16. Current regulatory requirements for PGPM products for management of seed, soil and plant health: An overview -- 17. Evolving Concepts of Biocontrol of Phytopathogens by Endophytic Pseudomonas fluorescence -- 18. Symbiotic Effectiveness of Rhizobium Strains in Agriculture -- 19. Inoculant Production and Formulation of Azospirillum Species.
    Abstract: This edited book aims to focus on microbial diversity in arid lands and deserts versus specific microbial assemblages associated with plants. The book explains ecological drivers that shape this diversity, how plant-associated microbiomes are selected, and their biotechnological potential are discussed. Diversity and functional redundancy of these associated PGPM make them very active in supporting plant improvement, health and resistance to drought, salt and other stresses, and these dimensions will be explored in this book. Implementing proper biotechnological applications of the arid and desert-adapted PGPM constitutes a sizeable challenge, and the book attempts to take up that challenge and help researchers in this field to gain a detailed understanding of PGPM from arid ecosystems. This book serves as a handbook for research workers, teachers, postgraduate students and extension personnel, other development workers, and policy planners engaged in arid zone development.
    Type of Medium: Online Resource
    Pages: XXII, 455 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811941245
    DDC: 579
    Language: English
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    Online Resource
    Online Resource
    Wiesbaden :Springer Fachmedien Wiesbaden :
    Keywords: Aging. ; Sociology. ; Social groups. ; Ethnology. ; Continuing education. ; Social structure. ; Equality. ; Social policy. ; Ageing. ; Sociology of Family, Youth and Aging. ; Sociocultural Anthropology. ; Lifelong Learning. ; Social Structure. ; Social Policy.
    Description / Table of Contents: History of ideas and epistemological approach -- Social gerontological centering -- Empirical findings from recent research -- Multiple interpretations.
    Abstract: Life must be conceived as the result of evolution and human life as the emergence of the species Sapiens from the genus Homo of the family of apes. If the emergence of human life as an evolutionary fact is coupled with the notion of social life, we are referred to the constructive production of human life forms, of which social participation is an integral part. On the one hand, participation is tied back to the phylogenesis of the species Sapiens, but on the other hand, it has to be acquired and practiced anew by every human being in the process of ontogenesis, depending on the environment. Participation in old age is a separate specification of the conditions of this process and can be illustrated on the basis of a large number of empirical findings. The content History of ideas and epistemological approach.- Social gerontological centering.- Empirical findings from recent research.- Multiple interpretations. The target groups Lecturers and students of the social sciences The author Prof. (ret.) Dr. Anton Amann hold the Chair of Sociology and Social Gerontology (1982-2006) and was Director of the Paul F. Lazarsfeld Archive (2001-2021), both at the University of Vienna. This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
    Type of Medium: Online Resource
    Pages: XIII, 194 p. 4 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783658396817
    DDC: 571.878
    Language: English
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  • 64
    Keywords: Drug delivery systems. ; Nanobiotechnology. ; Pharmaceutical chemistry. ; Tropical medicine. ; Pharmacology. ; Medical microbiology. ; Drug Delivery. ; Nanobiotechnology. ; Pharmaceutics. ; Tropical Medicine. ; Pharmacology. ; Medical Microbiology.
    Description / Table of Contents: Malaria: Cellular Understanding of Disease -- Drug Resistance, Statistics and Patent Status -- Malaria: Current Treatment Options -- Polymeric Nanoparticles in Malaria -- Solid Lipid Nanoparticles in Malaria -- Dendrimers in Malaria -- Liposomes in Malaria -- Micro and Nano Emulsions in Malaria -- Nanosuspension in Malaria -- Alginate and Gelatin Nanoparticles in Malaria -- Niosomes in Malaria -- Metal Nanoparticles in Malaria -- Nanotechnology in Malaria Diagnosis -- Nanotechnology-based Vaccination -- Herbal Platforms in Malaria -- Surface-modified Drug Delivery Systems in Malaria,- Clinical Trials in Malaria -- Malaria-Overall Picture -- New Drugs in Synthesis Research for Malaria -- Disease Models In Malaria Research.
    Abstract: The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause of significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future, primarily due to increased longevity that almost always comes at the cost of impaired immunity. A total of four books are covered under the series of Infectious drug diseases. - Malarial drug delivery systems - Tubercular drug delivery systems - Viral drug delivery systems - Infectious disease drug delivery systems The theme of the first book is Malaria. This book compiles the complete road map of malarial drug delivery systems by understanding the pathophysiology of the disease, the current state of malaria across the globe, new clinical trials, emerging drugs, and the development of novel drug delivery platforms. Various novel micro-and nano-formulations using promising technologies are being explored to deliver the malarial drug via different administration routes. This book addresses the gap between new approaches and old treatment modalities and how the former is superior in pharmacological performance when tested in in-vitro and in-vivo. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of malarial research.
    Type of Medium: Online Resource
    Pages: X, 395 p. 55 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031158483
    DDC: 615.6
    Language: English
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    Keywords: Microbiology. ; Diseases Causes and theories of causation. ; Microbial genetics. ; Microbiology. ; Pathogenesis. ; Microbial Genetics.
    Description / Table of Contents: Chapter 1. An introduction of microbial genomic islands for evolutionary adaptation and pathogenicity -- Chapter 2. Computation tools for prediction and analysis of genomic islands -- Chapter 3. An overview of genomic islands’ main features and computational prediction: the CMNR group of bacteria as a case study -- Chapter 4. Microbial genomic island discovery, visualization and analysis -- Chapter 5. Genomic islands in bacterial genome evolution and speciation -- Chapter 6. Genomic islands in the gut microbiome: current knowledge and the application in the probiotics field -- Chapter 7. Genomic islands in nutritional fitness and adaptation -- Chapter 8. Genomic islands involved in iron uptake -- Chapter 9. Genomic islands in uropathogeneic E. coli -- Chapter 10. Genomic islands in Helicobacter species -- Chapter 11. Genomic islands in Staphylococcus -- Chapter 12. Genomic islands in Pseudomonas species -- Chapter 13. Genomic islands in Klebsiella pneumonia -- Chapter 14. Molecular Insights into Genomic Islands and Evolution of Vibrio cholerae -- Chapter 15. Genomic islands in marine bacteria -- Chapter 16. Challenges in Eventing Horizontal Gene Transfer -- chapter 17. Artificial Intelligence and machine learning for prediction and analysis of genomic islands.
    Abstract: This book elucidates the role of microbial genomic islands (GEIs) in genome stability, plasticity, evolutionary adaptation, and pathogenicity in the bacterial population. The initial chapters of the book present tools, including bioinformatics, artificial intelligence, machine learning, next-generation sequencing, and molecular biology techniques, for the analysis of the genomic islands. The book also discusses the importance of genomic islands in bacterial speciation, acquisition of genes related to resistome, nitrogen fixation, mobilomes, and nutritional fitness and adaptation. It provides recent advances in understanding microbial genomic islands' distribution, evolution, and mechanistic modes of behavior in pathogenic, non-pathogenic, and environmental species. This book is a valuable source for beginners in molecular microbiology, students, researchers, clinicians, stakeholders, and policymakers interested in understanding the role of GEIs in the adaptive evolution of microorganisms.
    Type of Medium: Online Resource
    Pages: XXIII, 356 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811993428
    DDC: 579
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Biology. ; Neurosciences. ; Biotechnology. ; Drug delivery systems. ; Biomedical Research. ; Biological Sciences. ; Neuroscience. ; Biotechnology. ; Drug Delivery.
    Description / Table of Contents: Chapter 1.Deciphering New Drug Targets in Alzheimer’s Disease -- Chapter 2. Novel Therapeutic Targets for Treating Alzheimer’s Disease -- Chapter 3. Modified Investigation Tools and Techniques Useful in Alzheimer’s Disease Research -- Chapter 4. Dual Specificity Tyrosine Phosphorylation Regulated Kinase1A (DYRK1A) Inhibitors: The Quest for a Disease-Modifying Treatment for Alzheimer’s Disease -- Chapter 5. β-secretase as a primary drug target of Alzheimer disease: Function, Structure, and Inhibition -- Chapter 6. Endocrine Receptors: The Potential Therapeutic Targets for Alzheimer’s -- Chapter 7. Calcium Channels as a Potential Therapeutic Target for Alzheimer’s Disease -- Chapter 8. Traversing Through the Trajectory of Pathogenic Astrocytes in Alzheimer’s Disease -- Chapter 9. Targeting Mitochondrial Dynamics as a Restorative Approach in the Treatment of Alzheimer’s Disease -- Chapter 10. Epigenetic Therapy for Alzheimer’s Disease -- Chapter 11. Exploring the Diverse Roles of GSK-3ß Kinase in Alzheimer’s Disease -- Chapter 12. Role of Target Fishing in Discovery of Novel Anti-Alzheimer’s Agents: In Silico Applications -- Chapter 13. Multi-Target Directed Ligand Approach in Anti-Alzheimer’s Drug Discovery -- Chapter 14. Investigating the Role of Tau Proteins in Alzheimer’s Disease-From Typical Functioning MAPs to Aberrant Fibrillary Deposits in the Brain -- Chapter 15. The Overview of Drugs Used in Alzheimer’s Disease and Their Molecular Targets.
    Abstract: This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer’s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer’s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer’s disease treatment.
    Type of Medium: Online Resource
    Pages: XV, 381 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819926572
    DDC: 610.72
    Language: English
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    Keywords: Veterinary medicine. ; Physiology. ; Animal welfare Moral and ethical aspects. ; Ecology . ; Zoology. ; Veterinary Science. ; Animal Physiology. ; Animal Ethics. ; Ecology. ; Zoology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Physiology and Functional Anatomy -- Chapter 3. Sensory Systems -- Chapter 4. Biology of Stress -- Chapter 5. Normal Behaviour -- Chapter 6. Social Behaviour as a Challenge for Welfare -- Chapter 7. Brains, Behaviour, and Cognition: Multiple Misconceptions -- Chapter 8. Psychological and Behavioural Principles and Problems -- Chapter 9. Effects of Ontogeny, Rearing Conditions, and Individual Differences on Behaviour: Welfare, Conservation, and Invasive Species Implications -- Chapter 10. Controlled Deprivation and Enrichment -- Chapter 11. Effects of Noise and Light -- Chapter 12. Ethologically Informed Design and DEEP Ethology in Theory and Practice -- Chapter 13. Spatial and Thermal Factors -- Chapter 14. Nutritional Considerations -- Chapter 15. Naturalistic Versus Unnaturalistic Environments -- Chapter 16. Evidential Thresholds for Species Suitability in Captivity -- Chapter 17. Record Keeping as an Aid to Captive Care -- Chapter 18. Arbitrary Husbandry Practices and Misconceptions -- Chapter 19. Miscellaneous Factors.
    Abstract: This extensively revised and expanded new edition offers concepts, principles and applied information that relates to the wellbeing of reptiles. As a manual on health and welfare in a similar vein to volumes addressing the sciences of anatomy, behaviour or psychology, this book thoroughly examines the biology of reptile welfare and is about meeting biological needs. The editors, acknowledged experts in their own right, have once again drawn together an extremely impressive international group of contributors. Positive and negative implications of general husbandry and research programs are discussed. In addition to greatly revised original content are nine new chapters offering readers novel insight into: • sensory systems • social behaviour • brain and cognition • controlled deprivation and enrichment • effects of captivity-imposed noise and light disturbance on welfare • spatial and thermal factors • evidential thresholds for species suitability in captivity • record keeping as an aid to captive care • arbitrary husbandry practices and misconceptions The authors have adopted a user-friendly writing style to accommodate a broad readership. Although primarily aimed at academic professionals, this comprehensive volume is fundamentally a biology book that will also inform all involved in captive reptile husbandry. Among others, zoo personnel, herpetologists, veterinarians, lab animal scientists, and expert readers in animal welfare and behavioural studies will benefit from this updated work.
    Type of Medium: Online Resource
    Pages: XI, 638 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783030860127
    DDC: 636.089
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Metabolism. ; Molecular probes. ; Metabolism Disorders. ; Human Physiology. ; Metabolism. ; Biological Sensors and Probes. ; Metabolic Disease.
    Description / Table of Contents: 1. Biochemical Assay for Measuring Diabetes Mellitus -- 2. Diabetes and other comorbidities-Microvascular and Macrovascular diseases Diabetes and Cancer -- 3. Diabetes and Cardiovascular Disorder -- 4. Diabetes and Neurological Disorders -- 5. Diabetic and nephropathy -- 6. Technology in the management of type 1 and type 2 diabetes mellitus - recent status and future prospects -- 7. The Broader aspects of Treating Diabetes with the Application of Nanobiotechnology -- 8. A comprehensive pharmacological appraisal of Indian traditional medicinal plants with Antidiabetic potential -- 9. Diabetes management - From "Painful" pricks to "Painfree" bliss -- 10. Diabetes mellitus and iPSC based therapy -- 11. ketogenic diet and. Diabetics' of gut microbe on diabetics.
    Abstract: This book discusses the latest research in the pathophysiology, diagnosis, and screening of diabetes and its management. It reviews novel technologies for early diagnosis and highlights the molecular mechanisms of microvascular and macrovascular complications of diabetes 2 mellitus. The book covers the applications of nanotechnology in diagnostics, monitoring, and treatment of diabetes mellitus. The chapter also presents the latest developments in differentiating pancreatic cells from PSCs and illustrates the challenges of their therapeutic application in treating diabetes. The book also explores the prospective medicinal plants comprising either plant extract or isolated bioactive phytoconstituents bearing anti-diabetic potential, which has been reported in several in vitro, in vivo, or clinical studies. It further examines the major mechanisms involved in cardiovascular complications among type 2 diabetes mellitus individuals and discusses the various pharmacological interventions and agents developed to delay cardiovascular events and thereby the quality and duration of the patients. Towards the end, the book summarizes the potential impact of ketogenic diets on diabetic patients, and the role of genetic vulnerability in diabetic nephropathy. As such, this book is a valuable source for students, researchers, and practitioners working in glucose metabolism, diabetes, and human health.
    Type of Medium: Online Resource
    Pages: XII, 256 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811900273
    DDC: 612
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant anatomy. ; Plant physiology. ; Landscape architecture. ; Plant diseases. ; Agriculture. ; Plant Anatomy and Morphology. ; Plant Physiology. ; Landscape Architecture. ; Plant Pathology. ; Agriculture.
    Description / Table of Contents: Part-Dicotyledons -- 1. Basal Lineages -- 2. Magnoliids -- 3. Eudicots -- Index.
    Abstract: Horticulture has remained far behind in understanding of botanical principles. Recent phylogenetic (DNA-based) reorganization of higher plants has revolutionized taxonomic treatments of all biological entities, even when morphology does not completely agree with their organization. This book is an example of applying principals of botanical phylogenetic taxonomy to assemble genera, species, and cultivars of 200 vascular plant families of ferns, gymnosperms, and angiosperms that are cultivated for enhancement of human living space; homes, gardens, and parks. The emphases are on cultivated species but examples of some plants are often shown in the wild and in landscapes. In providing descriptions, it is assumed that students and other interested individuals have no background in general botany (plant characteristics), or nomenclature. Fundamental features of all plant groups discussed are fully illustrated by original watercolor drawings or photographs. Discussion of the families is grounded on recent botanical phylogenetic treatments, which is based on common ancestry (monophyly). Of course, phylogenetic taxonomy is not a new concept, and was originally based on morphological characteristics; it is the DNA-based phylogeny that has revolutionized modern biological classifications. In practical terms, this book represents the horticultural treatment that corresponds to phylogenetic-based botanical taxonomy, to which is added cultigens and cultivated genera and species. Hence, the harmony between horticultural and botanical taxonomy. This book covers phylogenetic-based taxonomy of Angiosperms (Eudicots). A companion volume covers Ferns, Gymnosperms, and Angiosperms (Monocots).
    Type of Medium: Online Resource
    Pages: XXXV, 1493 p. 1326 illus., 1325 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031115653
    DDC: 571.32
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Medical genetics. ; Genetics. ; Cell Biology. ; Medical Genetics. ; Clinical Genetics. ; Genetics.
    Description / Table of Contents: Introduction (MCG and FN) -- Updates on ATMP regulations from EU: experience with PRIME procedure and list of approved ATMP -- EU portal for clinical trials application -- European Pharmacopoeia texts on gene therapy medicinal products -- Updates on ATMP regulations from UK after Brexit and list of approved ATMP -- Updates on ATMP regulations from Switzerland and list of approved ATMP -- Updates on ATMP regulations from US FDA: experience with breakthrough/accelerated procedures and list of approved ATMP -- Updates on ATMP regulations from Canada and list of approved ATMP -- Updates on ATMP regulations from Brasil and list of approved ATMP -- Updates on ATMP regulations from Singapore and list of approved ATMP -- Updates on ATMP regulations from Japan: experience with new law and list of approved ATMP -- Updates on ATMP regulations from South Korea and list of approved ATMP -- Updates on ATMP regulations from Taiwan and list of approved ATMP -- Updates on ATMP regulations from Thailand and list of approved ATMP -- ATMP regulations in China and list of approved ATMP -- ATMP regulations in Australia and list of approved ATMP -- ATMP regulations in India and list of approved ATMP -- International harmonization programs. .
    Abstract: This book discusses the different regulatory pathways for Advanced Therapy Medicinal Products implemented by national agencies in North and South America, Europe and Asia and by international bodies in the effort of international harmonization. This book represents an update of the first edition, as it covers regulatory novelties and accumulated experience in the regions already addressed. In addition, this new edition offers a wider international perspective: new chapters are included covering Advanced Therapy Medicinal Products regulations in India, Malaysia, Spain and Thailand, the European Pharmacopoeia texts for gene therapy medicinal products as well as international harmonization programs. Each chapter, authored by experts from various regulatory bodies throughout the international community, walks the reader through the applications of nonclinical research to translational clinical research to licensure and therapeutic use of these innovative products. More specifically, each chapter offers insights into fundamental considerations that are essential for developers of Advanced Therapy Medicinal Products in the areas of product quality, pharmacology and toxicology, clinical trial design and HTA pathways, as well as pertinent ‘must-know’ guidelines and regulations. Regulatory Aspects of Gene Therapy and Cell Therapy Products: a Global Perspective is part of the American Society of Gene & Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals.
    Type of Medium: Online Resource
    Pages: IX, 242 p. 37 illus., 36 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031345678
    Series Statement: Advances in Experimental Medicine and Biology, 1430
    DDC: 571.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Immunology. ; Virology. ; Molecular biology. ; Immunology. ; Virology. ; Molecular Biology.
    Description / Table of Contents: Chapter 1. Pseudotyped Viruses -- Chapter 2. Assays based on Pseudotyped Viruses -- Chapter 3. Application of Pseudotyped Viruses -- Chapter 4. Pseudotyped Viruses for Retroviruses -- Chapter 5. Pseudotyped Virus for Papillomavirus -- Chapter 6. Pseudotyped Viruses for Marburgvirus and Ebolavirus -- Chapter 7. Pseudotyped Viruses for Coronaviruses -- Chapter 8. Pseudotyped Viruses for Influenza -- Chapter 9. Pseudotyped Virus Systems for Studies of Henipavirus -- Chapter 10. Pseudotyped Viruses for lyssavirus -- Chapter 11. Pseudotyped Viruses for Enterovirus -- Chapter 12. Pseudotyped Viruses for Orthohantavirus -- Chapter 13. Pseudotyped Viruses for Phlebovirus -- Chapter 14. Pseudotyped Virus for Bandavirus -- Chapter 15. Pseudotyped Viruses for Mammarenavirus -- Chapter 16. Pseudotyped Viruses for the Alphavirus -- Chikungunya Virus -- Chapter 17. Pseudotyped Virus for Flaviviridae -- Chapter 18. Replicating-competent VSV-vectored Pseudotyped Viruses.
    Abstract: This book intends to report the new progress of pseudotyped viruses, including the construction of pseudotyped viruses with different strategies or vectors for most important viruses. Especially for emerging viruses, optimization of the condition and parameters for assay development based on the pseudotyped viruses and widely application as surrogate of authentic virus to study the biological functions of virus, detection of neutralizing antibody, screening viral entry inhibiters, and others. It includes most pseudotyped viruses that have the protein of the target virus on the surface of the parent virus with incomplete genome. The book is likely to be of interest to all researchers in the field of virology, vaccine, and anti-viral drug development and evaluation.
    Type of Medium: Online Resource
    Pages: XIII, 348 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819901135
    Series Statement: Advances in Experimental Medicine and Biology, 1407
    DDC: 571.96
    Language: English
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  • 73
    Keywords: Drug delivery systems. ; Diseases. ; Pharmaceutical chemistry. ; Nanomedicine. ; Drug Delivery. ; Diseases. ; Pharmaceutics. ; Nanomedicine and Nanotoxicology.
    Description / Table of Contents: Global health and Tuberculosis past, present and Future -- Tuberculosis: cellular understanding of disease.-Metal nanoparticles in TB -- TB: current treatment options -- Polymeric nanoparticles in TB -- Solid lipid nanoparticles in TB -- Dendrimers in TB -- Liposomes in TB -- Micro, nano emulsions in TB -- Nano suspension in TB -- Alginate, gelatin nanoparticles in TB -- Niosome in TB -- Surface modified drug delivery systems in TB -- Clinical trials in TB -- Herbal platforms in TB.
    Abstract: The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the microorganisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity now and in the future, primarily due to increased longevity that almost always comes at a cost of impaired immunity. A total of four books are covered under the series of Infectious diseases. • Malarial drug delivery systems • Tubercular drug delivery systems • Viral drug delivery systems • Infectious disease drug delivery systems The theme of the second book is Tuberculosis (TB). This book addresses the recent trends in drug delivery for treating TB using new formulation technologies, and the mechanism how it can prevent or delay the drug resistance. It covers current drug therapy and new drug targeting approaches focusing on innovative trend-defining technologies and drug delivery platforms. It is essential to understand the relationship between host pathogens for better treatment. Various novel and nano-formulations using promising technologies are being explored to deliver TB drugs via different administration routes at right pathological site. This book addresses the gap between new and old treatment TB modalities and how they are superior in pharmacological performance when tested in in-vitro and in-vivo. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of TB research.
    Type of Medium: Online Resource
    Pages: X, 337 p. 51 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031141003
    DDC: 615.6
    Language: English
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    Keywords: Cancer Genetic aspects. ; Cancer Treatment. ; Cancer. ; Medical screening. ; Oncology. ; Cancer Genetics and Genomics. ; Cancer Therapy. ; Cancer Screening. ; Oncology.
    Description / Table of Contents: Part I. Epidemiology -- Family History and the Risk of Breast and Gastric Cancer -- Worldwide CDH1 Germline Mutation Frequency and the Transhormesis Hypothesis -- Hereditary Lobular Breast Cancer: A Newly Defined Syndrome -- Part II. Genetics -- Genetic Counseling and Prevention in Families at High Risk for HDGC and Other Hereditary Syndromes -- CTNNA1, a New HDGC Gene: Inactivating Mechanisms and Driven Phenotypes -- Revisiting the Biological and Clinical Impact of CDH1 Missense Variants -- Other Syndromes and Genes Associated with Gastric Cancer Predisposition -- Computer-Assisted Interpretation of Cancer-Predisposing Variants -- Part III. Pathology -- Histopathology of Hereditary Diffuse Gastric Cancer: From Grossing and 3D Microscopy to Immunophenotypic and Molecular Profiling -- HER2 Testing in Breast and Gastric Cancer with CDH1 Germline Mutations -- Pathology and Somatic Alterations in Hereditary Lobular Breast Cancers -- Part IV. Endoscopy and Imaging -- Endoscopy: Is there Anything New? -- Endoscopic Surveillance and Pathology of Biopsies in CDH1, CTNNA1 and HDGC-Like Families -- Lobular Carcinoma of the Breast: Spectrum of Imaging Findings and New Emerging Technologies on the Horizon -- Part V. Surgery -- Prophylactic Total Gastrectomy: Techniques -- Prophylactic Total Gastrectomy: How Many? -- Hereditary Lobular Breast Cancer Syndrome: Role of Surgery -- Breast Reconstruction -- Part VI. New Issues -- Psychological Burden and Preferences in CDH1 Mutation Carriers: Beyond the Cancer Diagnosis -- Drug Repurposing in Gastric Cancer: Current Status and Future Perspectives -- The Chemoprevention of Hereditary Diffuse Gastric Cancer -- Malformations and Malformative Syndromes Associated with CDH1 -- Hereditary Breast Cancer Non-CDH1 Associated -- Part VII. Patient Advocacy -- My Hereditary Gastric Cancer -- Hereditary Breast Cancer Syndrome, My Experience -- Part VIII. Miscellaneous -- β-Hemoglobinopathies and Early Onset of Cancers in Adulthood. Epidemiology in Southeastern Asia & Brunei with Emphasis for Prevention and Treatment.
    Abstract: In this book the editors and authors provide a comprehensive overview on basic research and clinical aspects of hereditary breast and gastric tumors. In particular, this updated editorial work aims to suggest guidelines for the clinical management of patients with hereditary diffuse gastric and lobular breast cancer. Special attention is given to E-cadherin (CDH1 gene) germline mutations, genetic screening approaches, the underlying molecular mechanisms and pathological and microscopic features. In addition, the book aims to define clinical criteria for genetic screening, and highlights current surgical treatment and clinical approaches for asymptomatic mutation carriers. Other inherited predispositions involving gastric and breast carcinoma are discussed as well. Divided into eight sections, the book starts by providing an epidemiological overview of gastric and breast cancers, followed by a section dealing with new descriptions of genetic pathways in hereditary cancer predispositions. The third section focuses on pathological features of the diseases, in an effort to bridge the gap between discovery and cancer therapy development. Subsequent sections of the book are dedicated to endoscopy and breast imaging, as well as risk-reducing surgeries to curb the risk of developing cancer. The sixth section focuses on the generation of ideas for the identification of targets and novel treatment strategies. Finally, in the seventh section the authors share the story of two patients and their experiences with the diagnosis and treatment of hereditary cancer. This multidisciplinary book brings together multiple disciplines in science and technology; specifically, medicine, surgery and biology. The majority of authors are members of the International Gastric Cancer Linkage Consortium (IGCLC) and of the European Cancer Prevention Organization (EJCPO), with relevant experience in this context. Offering in-depth insights into hereditary cancers, this book represents essential reading for students, researchers, and specialists who want to extend their knowledge on hereditary gastric and breast cancers.
    Type of Medium: Online Resource
    Pages: XV, 422 p. 58 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031213175
    DDC: 576.5
    Language: English
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  • 75
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Religion and sociology. ; Biotechnology. ; Biotechnology. ; Sociology of Religion.
    Description / Table of Contents: Preface -- Geography, Economy and Nationality of Shimenkan of Weining -- Methodist Churches in Zhaotong -- Shimenkan and Christianity -- Governance of the Miao nationality by the national government in Weining -- The Miao Nationality in Weining in Early People's Republic of China -- Social Reform of the Miao nationality in Weining -- Cooperative and People's Movement in Weining -- Socialist Education Movement" and "the Cultural Revolution" in Weining -- Reform and Opening up of Weining -- Shimenkan after Reform and Opening up -- Conclusion.
    Abstract: This book explores Shimenkan—a Miao-inhabited area in Weining County, China—and its rural society from a comprehensive and long-term perspective, drawing on research conducted by the author in the course of ten years. Located in the northwest of Weining County in Guizhou Province, Shimenkan is a multiethnic area, where, e.g., the Hans, Miaos, Yis, Huis, and Buyis live. Until the early twentieth century, it was a small mountain village; the introduction of Christianity led to significant cultural and social changes in this area. Focusing on China in the twentieth century, the book addresses the traditional culture of the Miao people, the popularity of Christianity in early modern times, the management and control by the government, the socialist reform in the period of the People’s Republic of China, and the changes following the reform and opening-up in recent years. Covering a century’s worth of history, it discusses the major historical events in Northeastern Yunnan and Northwestern Guizhou around Shimenkan and analyzes local social structures, religions, ideologies, customs, and ethnic psychologies, making it a valuable addition to the study of regional social history. The book draws on archives, literature reviews, and field surveys and pursues a multi-disciplinary approach combining history, anthropology, and other disciplines. It offers a valuable resource for researchers in history, religion, and ethnology, as well as readers interested in the spread of Christianity in the Miao-inhabited areas of southwestern China.
    Type of Medium: Online Resource
    Pages: XIV, 273 p. 45 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811989834
    DDC: 660.6
    Language: English
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  • 76
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Toxicology. ; Nanomedicine. ; Nanobiotechnology. ; Toxicology. ; Nanomedicine and Nanotoxicology. ; Medical Toxicology. ; Nanobiotechnology.
    Description / Table of Contents: Introduction -- Terminology -- nano -- polymer nanoparticles -- Nonpolymer nanoparticles -- Nanodevices -- Hybrid materials -- Nanocomposite -- Biomedical -- Further Reading -- Historical Development and Future Trends -- introduction -- Early Period -- Premodern period -- Middle Ages -- Modern Nanotechnology -- Regulations.-Scientific Trends -- Future Trends.-Small Systems Big Applications -- Smart Pills -- Beating the Big C -- Further Reading -- Sources and Classifications -- Introduction -- Properties -- Nanomaterials and Bulk Materials -- Sources -- Naturally produced -- Incidental -- Engineered Nanomaterials.-Classifications -- Natural NPs/NMs -- Incidental NPs -- Synthetic (Engineered) Nanomaterials (NMS) -- Dimensions Based Nanomaterials -- Nanoparticles -- Nanoclays -- nanoemulsions -- Further Reading -- Synthesis, Detection and Characterization -- Introduction -- Production Approaches -- Synthesis -- Physical Methods -- Chemical Methods -- Biological Approach -- magnetic nps -- Hybrid nanomaterials -- nanocomposites.-Detection -- Characterization and isolation -- Direct Techniques -- indirect Techniques -- Key Issues in Fabrication -- Further Reading -- Mechanisms of Nanotoxicty -- introduction -- Entry Sites and Uptake -- Elimination -- Phagocytosis -- Macropinocytosis -- Other Entry Mechanisms -- Intracellular Trafficking -- Trojan Horse Mechanism -- Cellular Exocytosis -- Cellular Dysfunction -- Inorganic Nanomaterial Toxicity -- Cell Deaths -- Further Readings -- Applications-. Introduction -- Nanoparticle-Based Technologies-. Agriculture -- Energy and Environment -- Materials Science and Engineering -- Materials Science and Engineering -- Health and Medicine -- Hybrid Nanomaterials -- Nanocomposites -- Further Reading -- Nano Based Drug Delivery Systems -- Introduction -- Overview in Biomedical Science -- properties of NP Drug Delivery -- Factors influencing Drug Laden Nanocarriers -- pH Specificity -- Temperature Specificity -- Temperature Specificity -- Advantages of Delivery Vehicles -- Nanocarriers -- Passive Targeting -- Active Targeting -- Uses and Applications -- Delivery Vehicles -- Organic Nanomaterials.-Poly-alkyl-cyano-acrylates (PAC) -- Artificial DNA Nanostructures -- Nanocomposites -- Hybrid nanoparticles -- Further Reading.-Tissue Engineering in Dentistry -- Introduction -- Materials for Dental Applications -- Structure and Periodontal Tissue -- Factors Affecting Bone Tissue Regeneration -- Periodontal Diseases -- Tissue Engineering -- Procedure -- Assembly Methods -- Bone Tissue Engineering -- Stem Cell Sources -- Signaling Molecules -- Scaffold/Matrices -- Bioactive Glasses -- Metal-Based materials -- Polymers -- Composites -- Scaffoldfree Techniques -- Biocompatibility -- Drug or Signaling Molecules Delivery -- Future Prospectives -- Further Reading -- Nanobiosensors -- Introduction -- Variations and Types -- Nanoparticle Based Sensors -- Nanotube Based Sensors -- Nanowire Based Sensors -- Components of a typical Biosensors -- Selection and Optimization -- -- Applications -- Cancer -- Detection of diabetes -- Immunoassay (detection of Ab-Ag reaction) -- Detection of pathogenic bacteria -- Future Prospects -- Further Reading -- Health and Medicine -- Introduction -- Keywords -- Nanostructures -- Polymers or Organic NPs -- Nonpoymers or Inorganic Nanoparticles -- Health and Medicine -- Neurodegenerative Disorders -- Tuberculosis -- Ophthalmology -- Respiratory diseases -- Surgery -- Toxicity -- Conclusion -- Further Reading Multiple Choice Questions. .
    Abstract: This book provides that knowledge needed to introduce individuals to the most important research and content on nanotoxicology in nanobiomedicine. Nanotechnology is helping to considerably improve, even revolutionize many technology and industry sectors: information technology, homeland security, medicine, transportation, energy, food safety, and environmental science, among many others. There is an urgent need for a general reference textbook that presents the most recent information on the toxicity and its effects in all these sectors, biomedicine in particular. It includes historical information, nanotoxicology by subject area and or disease, sources of nanomaterials, drug delivery systems and more. Scientists, researchers, and students in all fields that use nanotechnology will find this book essential reading.
    Type of Medium: Online Resource
    Pages: XVII, 179 p. 45 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031242878
    DDC: 615.90072
    Language: English
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  • 77
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Life sciences. ; Cytology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Life Sciences. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: Part I. Search for novel tumor epitopes related to carbohydrates -- Chapter 1.1. The ganglioside structures: chemistry and biochemistry -- Chapter 1.2. Fucosylated proteins as cancer biomarkers -- Part II. Assembly of glycoconjugates -- Chapter 2.1. Siglec-7 and synthetic sialylpolymer -- Chapter 2.2. Role of Sialyl-Tn antigen in Cancer Metastasis -- Chapter 2.3. Insights into the Role of Chondroitin Sulfate in Cancer -- Part III. Signaling pathways modulated by glycosylation -- Chapter 3.1. Significance of FUT8in pancreatic cancer and others -- Chapter 3.2. Effects of Bullfrog sialic acid-binding lectin in cancer cells -- Part IV. Interaction between carbohydrate and carbohydrate-recognizing molecules -- Chapter 4.1. Opposite functions of mono- and disialylated glycosphingolipids on the membrane of cancer cells -- Chapter 4.2. Tumor progression through interaction of mucins with lectins and subsequent signal transduction -- Part V. Clinical trials targeting glycosignals -- Chapter 5.1. Immunotherapy of Neuroblastoma Targeting GD2 and Beyond.
    Abstract: This book, now in an extensively revised second edition, provides a comprehensive summary of the latest knowledge regarding glycosignals and a thorough analysis of their involvement in not only cancers but also other refractory conditions such as chronic inflammatory disorders. Many relevant topics are covered, including the search for novel tumor epitopes related to carbohydrates, the assembly of glycoconjugates, the modulation of signaling pathways by glycosylation, and interactions between complex carbohydrates and their recognition molecules. The role of various research approaches, for example advanced mass spectrometry, high-resolution imaging, and bioinformatics, is closely examined, and the results of novel therapeutic trials targeting glycosignals are discussed. The book will be essential reading for students and young researchers with an interest in glycoscience. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.
    Type of Medium: Online Resource
    Pages: VI, 238 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789811977329
    DDC: 610.72
    Language: English
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  • 78
    Keywords: Microtechnology. ; Microelectromechanical systems. ; Microfluidics. ; Biomedical engineering. ; Microsystems and MEMS. ; Microfluidics. ; Biomedical Devices and Instrumentation.
    Description / Table of Contents: N/MEMS Biosensors: An Introduction -- Lab-on-a-Chip Technology in Health Care -- A Review on Recent Trends in the Segregation of Red Blood Cells Using Microfluidic Devices -- A Road Map to Paper-based Microfluidics towards affordable disease detection -- Critical Review and Exploration on Micro pumps for Microfluidic Delivery -- Fabrication Techniques & Materials for Bio-MEMS.-In-silico analysis of expandable radiofrequency electrode for ablation of hepatic tumors -- Lab-on-Chip Electrochemical Biosensor for Rheumatoid Arthritis -- Transdermal Injection with Microneedle Devices in Healthcare Sector: Materials, Challenging Fabrication Methodologies and its Limitations -- An economical and efficient method for the fabrication of spiral micromixer -- Damping Estimation and Analysis for High Performance Inertial MEMS for Early Detection of Neurological disorders during Pregnancy -- Affinity biosensing: Modeling of Adsorption Kinetics and Fluctuation Dynamics.
    Abstract: The book introduces the research significance of biomedical instrumentation and discusses micro-fabrication techniques utilized for biomedical devices. This book primarily focuses on the reader enlightenment on MEMS medical devices by introducing all the diagnostic devices and treatment tools at one place. The book covers in-depth technical works and general introductions to the devices such that the book can reach technical as well as non-technical readers.
    Type of Medium: Online Resource
    Pages: XII, 244 p. 131 illus., 121 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811987144
    Series Statement: Lecture Notes in Electrical Engineering, 989
    DDC: 621.381
    Language: English
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  • 79
    Keywords: Cytology. ; Virology. ; Neurosciences. ; Cancer. ; Stem cells. ; Sports medicine. ; Cell Biology. ; Virology. ; Neuroscience. ; Cancer Biology. ; Stem Cell Biology. ; Sports Medicine.
    Description / Table of Contents: Monkeypox and Sexually Transmitted Diseases -- Clinical Manifestations of Monkeypox -- Laboratory Diagnosis for Monkeypox: Clinical Practice and Important Points to Be Recognized -- Regulatory Mechanisms of Muscle Mass: The Critical Role of Resistance Training in Children and Adolescent -- HSF1 and Its Role in Huntington's Disease Pathology -- Leveraging Tissue Engineering for Skin Cancer Models -- Application of Drug Repurposing-Based Precision Medicine Platform for Leukaemia Patient Treatment -- Stem Cell-Derived Extracellular Vesicles as a Potential Therapeutic Tool for Eye Diseases: From Benchtop to Bedside -- Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy and Cancer Cells -- Direct Reprogramming of Somatic Cells into Induced β-Cells: An Overview.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 19th volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 194 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031284205
    Series Statement: Cell Biology and Translational Medicine, 1410
    DDC: 571.6
    Language: English
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  • 80
    Keywords: Freshwater ecology. ; Marine ecology. ; Invertebrates. ; Biotic communities. ; Biodiversity. ; Applied ecology. ; Water. ; Hydrology. ; Freshwater and Marine Ecology. ; Invertebrate Zoology. ; Ecosystems. ; Biodiversity. ; Applied Ecology. ; Water.
    Description / Table of Contents: Preface -- Chapter 1: Evolution of Bilateria from a Meiofauna Perspective – Miniaturization in the Focus -- Chapter 2: Meiofauna Shaping Biogeochemical Processes -- Chapter 3: Meiofauna and Biofilms – the Slimy Universe -- Chapter 4: Meiofauna Meets Microbes: Chemosynthetic Symbioses -- Chapter 5: Marine Meiofauna Diversity and Biogeography – Paradigms and challenges -- Chapter 6: Freshwater Meiofauna – a Biota with Different Rules? -- Chapter 7: Hidden Players – Meiofauna Mediates Ecosystem Effects of Anthropogenic Disturbances in the Ocean -- Chapter 8: Deep-Sea Meiofauna – a World of its Own or Deeply Connected? -- Chapter 9: Polar Meiofauna – Antipoles or Parallels? -- Chapter 10: Cave Meiofauna - Models for Ecology and Evolution -- Chapter 11: Meiofauna – Adapted to Life at the Limits -- Concluding Remarks -- Index.
    Abstract: Since research on meiobenthos was last compiled in a textbook (2008/2009), the number of theoretical and applied studies has been growing rapidly. Supported by new methods and digital evaluation, meiobenthology has developed into a wide field, with more and more researchers studying cross-disciplinary aspects. New perspectives were summarized in a booklet (2019) to draw attention to promising research directions. The present book, written by leading experts, is a compilation of new thinking, data, methods and approaches in many relevant fields of recent meiobenthos research. The topics addressed range from bacteria and biofilms to globally changing processes, from polar regions to the deep-sea and from freshwater ecosystems to the ocean. So, this book is not simply another meiobenthos textbook - it is an attempt to identify new horizons in meiobenthos research, driven by the vision of advancing knowledge and understanding of benthic ecosystems.
    Type of Medium: Online Resource
    Pages: XII, 407 p. 49 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031216220
    DDC: 577.6
    Language: English
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  • 81
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Neurosciences. ; Immunology. ; Physiology. ; Neuropsychology. ; Psychiatry. ; Neuroscience. ; Immunology. ; Physiology. ; Neuropsychology. ; Psychiatry.
    Description / Table of Contents: 1.How Immune-inflammatory processes link neurodegenerative and psychiatric disorders -- 2.Gut-Microbiota-Brain Axis: pathophysiological mechanism in neuropsychiatric disorders -- 3.Microbiome- induced autoimmunity and novel therapeutic intervention -- 4.The key role of microlia and circulating monocytes in etipathology neuropsychiatric disorders -- 5.Neuro-immuno-epigenetics of prenatal psychological stress -- 6.C-reactive protein (CRP): a potent inflammation biomarker in psychiatric disorders -- 7.Neuroinflammation, neurognesis and neuroprotection in schizophrenia -- 8.Autoimmue psycosis: concept, clinical manifestation and management -- 9.Stress, autonomic nervous system and kynurenine pathway in major depression -- 10.Brain-gut-microbiome axis in major depression : novel therapeutic approach -- 11.Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder -- 12.Neuroimmaging of inflammation in depression and anxiety disorders -- 13.Neuroinflammation and immune-kynureinine pathway in anxiety disorders -- 14.Inflammatory-mediated responses in development of neurogeneartive diseases -- 15.The connection between gut-brain axis and PTSD -- 16.Eating disorders : Gut microbiota-immune-brain interactions -- 17.Sleep-immune crosstalk and sleep disorders -- 18.Obsessive-compulsive disorder: immuno-inflammatory disorder? -- 19.Cytokine, neuroinflammation and neurodeneration in Alzheimer’s disease -- 20.Molecular imaging of neuroinflammation in Alzheimer's disease and MCI -- 21.The role of N-Methyl-D-Aspartate Receptor Neurotransmission and mictobiota in Alzheimer’s disease -- 22.Neuroglial activation and neuroinflammation in the brain of patients with autism -- 23.Suicide and inflammation -- 24.Anti-inflammatory effect of Traditional Chinese Medicine on the concept of Mind-body interface -- 25.Anti-inflammatory therapy as a promising target in neupsychiatric disorders.
    Abstract: This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
    Type of Medium: Online Resource
    Pages: XVII, 554 p. 28 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811973765
    Series Statement: Advances in Experimental Medicine and Biology, 1411
    DDC: 612.8
    Language: English
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  • 82
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurophysiology. ; Gastroenterology. ; Neuroscience. ; Neurophysiology. ; Gastroenterology.
    Description / Table of Contents: Tools for optogenetic probing of nociceptive pathways; Monitoring activity -- An open science model to accelerate the generation, implementation and distribution of optogenetics and viral tools -- Vagal neuroinflammation accompanying respiratory viral infection: An overview of mechanisms and possible clinical significance -- Stress-induced Visceral Analgesia: Concept and Pathways -- Evidence of early life stress exposure and epigenetic modifications in functional chronic pain disorders -- EPIGENETIC REGULATION OF STRESS-INDUCED VISCERAL PAIN -- The biomechanics and mechanotransduction in visceral nociception -- VISCERAL NOCICEPTION IN GASTROINTESTINAL DISEASE -- Epithelial-Neuronal Communication in Visceral Pain -- Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome -- A fentanyl analogue that activates u-opioid receptors in acidified tissues inhibits colitis pain without opioid side effects -- Signalling in the Gut -- Translating colonic sensory afferent peripheral mechanosensitivity into the spinal cord dorsal horn -- Translating colonic afferent peripheral sensitivity into the spinal cord dorsal horn -- Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain -- Pre-clinical Models of Endometriosis -- Spinal afferent innervation of the uterus -- Post-infectious bladder hypersensitivity in the development of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).
    Abstract: The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility in 2021. This is one of the hottest fields of science and includes mechanisms involving how the microbiome communicates with the brain and how, when disordered, these mechanisms contribute to clinical diseases such as Irritable Bowel Syndrome and Inflammatory Bowel Disease. Researchers from around the globe presented their latest findings as a review of the current state of the art in the field from both the clinical and scientific points of view. These systems are now appreciated as being critical for shaping our well-being and their disorders underlie chronic clinical conditions of significant morbidity and mortality. The author team includes long-established authorities who significantly contributed to the advances in visceral pain research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.
    Type of Medium: Online Resource
    Pages: VIII, 255 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031257025
    DDC: 612.8
    Language: English
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  • 83
    Online Resource
    Online Resource
    Dordrecht :Springer Netherlands :
    Keywords: Botanical chemistry. ; Chemistry, Organic. ; Pharmaceutical chemistry. ; Plant Biochemistry. ; Organic Chemistry. ; Pharmaceutics.
    Description / Table of Contents: Chronology -- Abbreviations -- Preface and acknowledgements -- 1. Introduction -- 2. l-Physostigmine (eserine) -- 3. l-Physovenine -- 4. l-Eseramine -- 5. l-N(8)-Norphysostigmine -- 6. l-Geneserine -- 7. 1H-, 13C- and 15N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean -- 8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean -- 9. Non-alkaloidal components of the Calabar bean -- 10. Biological activities of the alkaloids of the Calabar bean -- 11. Notes -- 12. References -- 13. Index.
    Abstract: Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a “lead compound”) have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial.
    Type of Medium: Online Resource
    Pages: XXVI, 267 p. 240 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789402411911
    DDC: 572.2
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuropsychology. ; Psychiatry. ; Neuroscience. ; Neuropsychology. ; Psychiatry.
    Description / Table of Contents: Part 1: Considering sex and gender in research studies -- Sex and Gender Science -- Best practices in the study of sex? -- Best practices in the study of Gender Differences -- The special case of a lack of sex differences – the naked mole rat? -- Lateralization and -- Part 2: Sex differences in cognitive and mental health across the lifespan -- Depression -- Schizophrenia -- Immune and neurodevelopmental disorders – autism? -- Social Cognition -- Cognition and cognitive ageing -- Part 3: Diseases of the brain and relevance of sex -- Epilepsy -- Stroke -- AD -- Parkinson’s -- Multiple Sclerosis.
    Abstract: Does sex matter when it comes to brain function? This volume attempts to answer this very important question which is of relevance to the disciplines of psychology, neuroscience, psychiatry and neurology. Understanding how brain function and resultant behaviors may differ between the sexes impacts upon our knowledge of the pathology and development of treatments for various neurological and psychiatric disorders, particularly those that show significant sex differences in either prevalence and/or manifestation of symptoms. This volume covers three main themes of research into sex differences in basic neurobiology, psychology, preclinical research and clinical research. It begins by exploring our understanding of sex and gender in relation to both animal and human behaviors and discusses the relevance, and importance, of considering sex and gender when conducting research into brain function and behaviors. The second theme focuses on how sex and gender influence mental health and considers the impact of our immune system and the changes that occur with ageing. Finally, the third aspect focuses on examples of neurological disorder which show sex differences in terms of their aetiology and/or symptomology and considers the relevance in the development of treatment for these disorders including dementia, stroke and multiple sclerosis. This volume is of considerable interest to mental health and neurology professionals, including psychiatrists, neurologists, nurses, allied health clinicians and pharmacists. It is also helpful and important for preclinical researchers working in neuroscience, psychopharmacology and reproductive endocrinology.
    Type of Medium: Online Resource
    Pages: X, 373 p. 70 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031267239
    Series Statement: Current Topics in Behavioral Neurosciences, 62
    DDC: 612.8
    Language: English
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  • 85
    Keywords: Medical sciences. ; Statistics . ; Health Sciences. ; Applied Statistics.
    Description / Table of Contents: Preface -- Chapter 1: Regression Analysis -- Chapter 2: Cox Regressions -- Chapter 3: Accelerated Failure Time Models -- Chapter 4: Simple Dataset with Event as Outcome and Treatment as Predictor -- Chapter 5: Simple Dataset with Death as Outcome and Treatment Modality, Cholesterol, and Age as Predictors -- Chapter 6: Glioma Brain Cancer -- Chapter 7: Linoleic Acid for Colonic Carcinoma -- Chapter 8: The Effect on Survival of Maintained Chemotherapy with Acute Myelogenous Leucemia -- Chapter 9: Eighty Four Month Parallel Group Mortality Study -- Chapter 10: The Effect on Survival from Stages 1 and 2 Histiocytic Lymphoma -- Chapter 11: Survival of 64 Lymphoma Patients with or without B Symptoms -- Chapter 12: Effect on Time-to-Event of Group Membership -- Chapter 13: The Effect on Survival of Group Membership -- Chapter 14: Deaths from Carcinoma after Exposure to Carcinogens in Rats -- Chapter 15: Effect of Group Membership on Survival -- Chapter 16: Multiple Variables Regression Study of 2421 Stroke Patients Assessed for Time to Second Stroke -- Chapter 17: Hypothesized 55 Patient Study of Effect of Treatment Modality on Survival -- Chapter 18: One Year Follow-up Study with Many Censored Patients -- Chapter 19: Alcohol Relapse after Detox Program Treated with or without Personal Coach -- Chapter 20: Alcohol Relapse after Detox Program with 3 Predictors -- Chapter 21: Ayurvedic Therapy for Human Immunodeficiency Virus -- Chapter 22: Time to Event other Than Cox -- Chapter 23: Abstracts of the Chapters 1 to 22.
    Abstract: An important novel menu for Survival Analysis entitled Accelerated Failure Time (AFT) models has been published by IBM (international Businesss Machines) in its SPSS statistical software update of 2023. Unlike the traditional Cox regressions that work with hazards, which are the ratio of deaths and non-deaths in a sample, it works with risk of death, which is the proportion of deaths in the same sample. The latter approach may provide better sensitivity of testing, but has been seldom applied, because with computers risks are tricky and hazards because they are odds are fine. This was underscored in 1997 by Keiding and colleague statisticians from Copenhagen University who showed better-sensitive goodness of fit and null-hypothesis tests with AFT than with Cox survival tests. So far, a controlled study of a representative sample of clinical Kaplan Meier assessments, where the sensitivity of Cox regression is systematically tested against that of AFT modeling, has not been accomplished. This edition is the first textbook and tutorial of AFT modeling both for medical and healthcare students and for professionals. Each chapter can be studied as a standalone, and, using, real as well as hypothesized data, it tests the performance of the novel methodology against traditional Cox regressions. Step by step analyses of over 20 data files stored at Supplementary Files at Springer Interlink are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology (2000-2002). From their expertise they should be able to make adequate selections of modern data analysis methods for the benefit of physicians, students, and investigators. The authors have been working and publishing together for 25 years and their research can be characterized as a continued effort to demonstrate that clinical data analysis is not mathematics but rather a discipline at the interface of biology and mathematics.
    Type of Medium: Online Resource
    Pages: XIV, 224 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031316326
    DDC: 610
    Language: English
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  • 86
    Keywords: Neurosciences. ; Neurology . ; Pharmaceutical chemistry. ; Cognitive neuroscience. ; Neuroscience. ; Neurology. ; Pharmaceutics. ; Cognitive Neuroscience.
    Description / Table of Contents: Part I: Basic Science of Cerebellum and Ataxias -- Functional anatomy of the cerebellum -- Cerebellar physiology -- Cerebellar biochemistry/pharmacology -- Genetics of dominant ataxias -- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics -- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches -- Ion Channel Genes and Ataxia -- Part II: Biomarkers and tools of trials -- How to Design a Therapeutic Trial in SCAs -- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers -- Clinical rating scales for ataxia -- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding -- Cerebellar learning in the prism adaptation task -- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias -- Part III: Autosomal Dominant Cerebellar Ataxias -- Riluzole in progressive cerebellar ataxias -- ASOs against ATXN2 in preclinical and phase 1 trials -- Antisense oligonucleotide therapy against SCA3 -- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities -- Experimental neurotransplantation for cerebellar ataxias -- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside -- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia -- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias -- Physical therapy in Cerebellar Ataxia -- Part IV: Autosomal Recessive Cerebellar Ataxias -- Recent advances on therapeutic approaches for Friedreich’s Ataxia -- Therapeutic use of interferon gamma in Friedreich ataxia -- Metabolic treatments of cerebellar ataxia -- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome -- Part V: Sporadic Ataxias -- Therapeutic strategies in immune-mediated cerebellar ataxias -- Coenzyme Q10 in MSA -- State of the Art and History of Therapeutics in Ataxias.
    Abstract: Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
    Type of Medium: Online Resource
    Pages: XI, 727 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031243455
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 87
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Parasitology. ; Medical microbiology. ; Stem cells. ; Parasitology. ; Medical Microbiology. ; Stem Cell Biology.
    Description / Table of Contents: Chapter 1_Introduction to malaria biology in a liver -- Chapter 2_Modeling a liver-stage malaria -- Chapter 3_Liver organoid and liver-on-a-chip -- Chapter 4_Generation of liver organoid -- Chapter 5_Generation of liver-on-a-chip -- Chapter 6_The use of 3D in vitro systems to model human malaria.
    Abstract: This book illustrates the importance and advances of the disease model for malaria, a globally affected public health problem. This book provides comprehensive information on the malaria biology in a liver and all in vitro platforms for liver-stage malaria, including principles, protocols, applications for disease modeling and drug screening, and their limitations. The initial chapter describes the basis of stem cells in liver generation during development and in adults. The subsequent chapters highlight recent and emerging advances in liver organoid and liver-on-a-chip in modeling malaria. The book presents current protocols and methods to generate liver organoid and liver-on-a-chip together with their advantages and limitations. Toward the end, the book examines the humanized mouse model of liver-stage malaria using ectopic artificial livers regarding novel readout modalities. The recent advancement and challenges in combining liver-on-a-chip technology with biosensors are highlighted for assessing hepatocyte development viability and functions. The book elucidates the potential of these 3D models to understand the biological complexity of cellular and molecular mechanisms involved in Plasmodium development in the liver, toolboxes to investigate parasite deployment in the 3D models, and to implement in drug discovery. Finally, the book discusses the future directions and challenges in the applications of liver organoids and liver on-chip in the biology of live-stage malaria. This book is helpful for researchers and scientists in the field of parasitology, cell biology, tissue engineering, and pharmacology.
    Type of Medium: Online Resource
    Pages: XI, 94 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819906918
    DDC: 571.999
    Language: English
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  • 88
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Botany. ; Agriculture. ; Biomolecules. ; Physical biochemistry. ; Macromolecules. ; Plant Science. ; Agriculture. ; Structural Biology.
    Description / Table of Contents: 1. Introduction -- 2. Floral morphology and phenology -- 3. Pollen grain morphology, viability, and insect visitation -- 4. The phenology of Rubus glaucus Benth. characterized by the BBCH scale -- 5.Propagation and cultivation -- 6.Fruit and chromosome number -- 7.Post-harvest physiology and nutritional facts -- 8.Genetic diversity -- 9.Breeding programs -- 10.Morphological diversity -- 11.Rubus glaucus and climate change.
    Abstract: The current book focuses on Mora de Castilla (Rubus glaucus Benth.). It explores aspects, such as origin, phenology, propagation, floral and fruit morphology, arthropod visitors, pollination mechanisms, propagation methods, chromosome number, fruit development, breeding, morphological diversity, and the impact of climate change. It includes novel data about plant phenology, flowering, insect visitors, seed germination, fruit morphology, and allometric relationships. This work includes an in-depth review of the most recently published information on the topic. Mora de Castilla is an economically important fruit crop from the Andes. It has been crossed with other Rubus species due to its high yield and everbearing habit. Currently, it is an economically important plant. It has been hybridized with other Rubus species producing new and better-quality hybrids This book contains numerous photographs selected by the author to provide the reader with detailed information about the plant´s morphological features and arthropod visitors. .
    Type of Medium: Online Resource
    Pages: XVIII, 178 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031317507
    DDC: 580
    Language: English
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  • 89
    Keywords: Freshwater ecology. ; Marine ecology. ; Microbiology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Freshwater and Marine Ecology. ; Microbiology. ; Environmental Engineering/Biotechnology.
    Description / Table of Contents: 1. Marine Biotechnology: A Frontier for the Discovery of Nutraceuticals, Energy, and Its Role in Meeting 21st Century Food Demands -- 2. Biotechnological Utilization of the Marine Environment for Food, Drugs and Energy -- 3. Grouper Hybridization: An Effective Biotechnological Tool for Food Security -- 4. The Application of Molecular Markers to Fish Breeding and Aquaculture -- 5. Aquaculture and Applications of Green Seaweeds of the Genus Caulerpa J.V. Lamouroux, 1809 -- 6. Potential and Challenges of Sea Cucumber Holothuria Scabra Mariculture in Sabah, Malaysia -- 7. Sea Cucumber (Echinodermata: Holothuroidea) Species Diversity on the West Coast of Sabah, Malaysia -- 8. Sea Cucumbers: Source of Nutritional, Medicinal, and Cosmeceutical Products -- 9. Marine Biotechnology and its Applications in Drug Discovery -- 10. Bacteriophage as Therapeutic Strategy Against Pathogenic Vibrio -- 11. Bacterial Diversity in the Marine Environment and the Cutting-edge Tools for Isolation, Identification, and Characterization of the Marine Microbiome -- 12. Biotechnological Applications of Jellyfish-Derived Products -- 13. Application of Biotechnology in White Syndrome Coral Disease Identification -- 14. The Synergy of Remote Sensing in Marine Invasion Science -- 15. The Utilization of Agro-based Wastes by Marine Phototrophic Microbes -- 16. Artificial Intelligence Methods in Marine Biotechnology.
    Abstract: This contributed volume covers the applications of marine biotechnology for food, drugs and energy production using marine resources. It introduces many aspects of marine biotechnology, including bioenergy, pharmaceutical development, food security from mariculture, pollution handling, legal issues and conflicts. Information in the book is accompanied by clear images, flow charts, quantitative and qualitative data. Marine biotechnology is essential for realizing the previously untapped potential of marine bio-resources. These resources are used to develop innovative goods and procedures that aid in the global management of food, energy, and disease management. The development of innovative tools and solutions for more sustainable marine environmental management is another important section of this title. This reference book is of interest to teachers, researchers, and climate change scientists. It serves as an additional reading material for college, undergraduate, and graduate students of marine science and aquaculture. This is also a good research guide for food and fishing industry scientists.
    Type of Medium: Online Resource
    Pages: XIII, 354 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819906246
    DDC: 577.6
    Language: English
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  • 90
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Stem cells. ; Regenerative medicine. ; Medical microbiology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Medical Microbiology.
    Description / Table of Contents: The Art of Cell Therapy -- Scope and Applicability of Autologous Cell Therapies -- Scale and Accessibility of Allogeneic Cell Therapies -- Acellular Stem Cell Products. Potency Assays: The Buggy Boo of Stem Cell Therapy -- Potency Assay Development: A Keystone for Clinical Use -- Quantifying Critical Quality Attributes -- Advanced Technologies for Potency Assay Measurement -- Potency Quality by Design: Tailoring for Specific Therapy -- Contract Research Organizations Expediting Therapeutic Availability -- Regulatory Authority Perspectives for Potency Release Criteria -- Illustrative Potency Assay Examples from Approved Therapies -- The Integrity of Potency Assays and Safe Intervention -- The Evolving Landscape of Potency Assays.
    Abstract: This volume of the Springer book series Advances in Experimental Medicine and Biology covers potency assays, one of the most complex yet fundamental evaluations that critically influence stem cell regenerative medicine. Developing potency assays for cell-based medicinal products comes with numerous challenges due to the highly specialised nature of the application and purpose. This book provides the reader with the knowledge necessary to understand issues governing the successful development of potency assays, highlighting an international outlook of how the various challenges raised are being managed. Stakeholders concerned with potency assay development range from patient and clinician to contract research organisations, small and medium enterprise, regulatory authorities and even politicians. The value of potency assays is poised to increase given the inevitable watershed as early-stage clinical trials addressing safety progress to trials testing efficacy. Contributors from clinical, academic, industrial and regulatory sectors establish a broad point of view for guidance and timely debate. Potency assays require extensive collaboration across disciplines and sectors, as well as compromise and the authors aim to constructively address the many key aspects involved. Potency assays provide a quantitative measure of the biological activity of advanced therapy medicinal products (ATMPs) and thus are required for their market authorization. As the pace of ATMP development accelerates, the need to develop specific, accurate, and robust potency assays for each product is also accelerating. The volume Potency Assays for Stem Cell Advanced Therapy Medicinal Products presents a broad outlook on the development, quality attributes, and implementation of potency assays for ATMPs. The first few chapters introduce a nuanced historical perspective on the science of potency assay development, describe specific quality attributes of an idealized potency assay, indicate pitfalls associated with developing such assays for ATMPs, and review guidance recommended by regulatory authorities on assay suitability for product approval. Subsequent chapters highlight efforts to develop potency assays for specific ATMPs, including skeletal stem cells, mesenchymal stromal cells, extracellular vesicles, CAR T-cells, and discuss emerging technologies/platforms for potency assay design. The volume concludes with a chapter reviewing potency assays used for the release of commercial ATMP products, which amalgamates information contained in previous chapters. Overall, the knowledge contributed from leading authorities in both academia and industry is an ideal resource for technicians, scientists, clinicians, process engineers, and regulators working with ATMPs. —Donald G. Phinney, PhD Professor, Department of Molecular Medicine, Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology .
    Type of Medium: Online Resource
    Pages: XIX, 214 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031300400
    Series Statement: Advances in Experimental Medicine and Biology, 1420
    DDC: 571.6
    Language: English
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  • 91
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biology Philosophy. ; Philosophy of nature. ; Ontology. ; Philosophy of Biology. ; Philosophy of Nature. ; Ontology.
    Description / Table of Contents: Chapter 1 Distinction-Distinguishing -- Chapter 2 Distinguishing Distinctions -- Chapter 3 ב and the Emergence of Living Being -- Chapter 4 Empirical Evidence for ב -- Chapter 5 Formal Definition of Distinction -- Chapter 6 The Mathematical Ideal and the Elision of the Subject -- Chapter 7 Four Kinds Of Things -- Chapter 8 [Subjects] -- Chapter 9 Living Being -- Chapter 10 The Paradoxical Nature of Aliveness and [Ethics].
    Abstract: This book proposes a bold idea. Living beings are distinguishing distinctions. Single cells and multicellular organisms maintain themselves distinct by drawing distinctions. This is what organisms are and what they do. From this starting point, key issues examined range across ontology, epistemology, phenomenology, logic, and ethics. Topics discussed include the origin of life, the nature and purpose of biology, the relation between life and logic, the nature and limits of formal logic, the nature of subjects, the subject-object relation, subject-subject relationships and the deep roots of ethics. The book provides a radical new foundation to think about philosophy and biology and appeals to researchers and students in these fields. It powerfully debunks mechanical thinking about living beings and shows the vast reservoir of insights into aliveness available in the arts and humanities. .
    Type of Medium: Online Resource
    Pages: XIX, 320 p. 36 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031247897
    Series Statement: Biosemiotics, 26
    DDC: 570.1
    Language: English
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  • 92
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Botany. ; Ecology . ; Biodiversity. ; Biotic communities. ; Population biology. ; Plant Science. ; Ecology. ; Biodiversity. ; Community and Population Ecology.
    Description / Table of Contents: 1 -- Introduction -- 2. Southern tropical and subtropical rainforests -- 3. Multi-faced southern seasonal tropics 3.1 Heterogeneity of the savanna biomes: a southern perspective -- 4. Southern mediterranean: an extratropical plant marvel -- 5. Dry face of the ‘wet hemisphere’: southern deserts and semideserts -- 6. Austral temperate forests: a biome-classification conundrum -- 7. Southern ‘steppes’ and other grassy oddballs -- 8. The biomes of the coldest corners of the World -- 9. Synthesis: A New Global Zonobiome System -- 10. Further Challenges and Research Agenda -- References.
    Abstract: This is the first comprehensive and critical evaluation of the biome (large-scale, functional biotic communities) patterns in the Southern Hemisphere. Revising the Heinrich Walter's zonobiome system for the Southern Hemisphere appeared as necessary because of the bioclimatic imbalance between the Hemispheres. This revision resulted in formulation of a new zonobiome system, considering the geographic peculiarities of both Hemispheres, hence creating a new, powerful tool of global nature-resource survey and conservation. The system has a potential to attract the interest of the global climate modeling community as the concept of biome (and associated hierarchical system) has a strong functional focus. All zonal biomes of the Southern Hemisphere are featured, and the major challenges we face in understanding their origins, structure, and functioning are discussed. The book contains a wealth of original data resulting from collation of bioclimatic data and vegetation mapping.
    Type of Medium: Online Resource
    Pages: XIV, 219 p. 71 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031267390
    Series Statement: Biome Ecology, 1
    DDC: 580
    Language: English
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  • 93
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: Chapter 1: Understanding the Mechanisms of Dendritic Arbor Development: Integrated Experimental and Computational Approaches -- Chapter 2: Autophagy Mechanisms for Brain Recovery. Keep It Clean, Keep It Alive -- Chapter 3: Environmental enrichment and functional plasticity in the hippocampus, an update on the mechanisms involved -- Chapter 4: Translatable Models of Brain and Cognitive Reserve -- Chapter 5: Cognitive Reserve: A Life-Course Perspective -- Chapter 6: Neural Correlates of Brain Reserve: A Neuroimaging Perspective -- Chapter 7: Non-pharmacological Approaches Based on Mind-Body Medicine to Enhancement of Cognitive and Brain Reserve in Humans -- Chapter 8: Roles of Synaptic Plasticity in Functional Recovery After Brain Injury -- Chapter 9: Integrated Methods of Neuromodulation for Guiding Recovery Following Stroke -- Chapter 10: Resilience in Brain Networks After Stroke -- Chapter 11: Epigenetics and brain plasticity: back to function -- Chapter 12: Functional Role of Physical Exercise and Omega-3 Fatty Acids on Depression and Mood Disorders -- Chapter 13: BRAIN RECOVERY IN CHILDHOOD: THE INTERACTION BETWEEN DEVELOPMENTAL PLASTICITY AND REGENERATIVE MECHANISMS -- Chapter 14: Estrogen Neuroprotective Activity After Stroke and Spinal Cord Injury -- Chapter 15: Making Meaning of Acquired Brain Injury: Resources for Functional Recovery -- Chapter 16: An Update on Premorbid Personality Traits and Brain Recovery - Another Aspect of Resilience -- Chapter 17: Psychological Aspects of Recovery After Brain Injury: A Focus on Psychodynamic Factors -- Chapter 18: Artificial Intelligence applications for Traumatic Brain Injury research and clinical management.
    Abstract: The importance of this unique book's approach lies in addressing the impact of neurobiological factors as well as psychological influences on brain recovery following injury. There is growing evidence that emotional, motivational, and cognitive factors along with personality traits play a crucial role in brain plasticity, resilience, and recovery. Topics include synaptic and neuronal plasticity, development of brain reserves, biological markers, environmental factors, emotional resilience, and personality traits. By combining the latest research on neural mechanisms and psychological resilience the authors present a book that will help lead to the development of better treatment strategies for functional recovery from brain damage. The new edition is fully updated throughout and contains completely new chapters on brain recovery in childhood, epigenetic aspects of brain recovery, and artificial intelligence techniques in traumatic brain injury research.
    Type of Medium: Online Resource
    Pages: XXIV, 406 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031249303
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 94
    Keywords: Botany. ; Judaism. ; Religion and science. ; Arts. ; Plant Science. ; Judaism. ; Religion and Sciences. ; Arts.
    Description / Table of Contents: The Biology of the Citron -- Citron Genomics -- Citron Phytochemistry -- Selected Aspects of Commercial Production in Etrog Orchards -- Preserving Etrog Quality After Harvest: Doctrine and Practice -- Citron Arthropod Pests in the Mediterranean, Their Origin and Notes On Their Biology and Management -- Diseases of the Etrog Citron and Other Citrus Trees -- The Citron ( Citrus medica L.) in China -- The Citron in Italy and Its cultivation in Calabria -- The Citron in Corsica -- The Citron in the United States -- The Citron in Mediterranean Food and Beverages -- 'Fruit of the Goodly Trees’: The Talmudic Discourse on the Etrog Citron -- From Theophrastus to the Present: The Citron in Medicine -- The Etrog Citron in Art -- The Etrog Citron in Midrashic and Kabbalistic Literature -- From ‘An Etrog’ to ‘One's Etrog’: A Literary Analysis of S.Y. Agnon’s Story -- History of the Citron in Ancient Israel and the Near East -- The Etrog Citron Trail to the North: Genoa and Trieste -- The Corfu Etrog Citron Polemic -- The Grafted Etrog Citron Controversy -- Etrog Citrons of the Land of Israel in Modern Times.
    Abstract: This comprehensive book covers the theoretical and practical aspects of citron trees and fruit. The citron (Citrus medica L.), one of the three primary species ancestral to most citrus types, is used for traditional medicine and is highly revered in the Jewish religion during the Tabernacles feast, referred to by the name 'Etrog'. This book’s three sections address biology (botany, genomics, Chinese and Mediterranean citrons, diseases, pests, and horticulture), tradition (Talmudic discourse, mysticism, medicine, literature, art, food, and beverages) and history (archaeology, trade, grafting controversies); these sections are supplemented by a glossary and pictorial album. The 22 chapters, some new and some translated and considerably expanded from the 2018 Hebrew edition, were written by world-renowned specialists from Israel, Italy, France, the U.S.A., China and Australia. The book is written in an accessible scientific style aimed at a wide range of readers. .
    Type of Medium: Online Resource
    Pages: XVIII, 607 p. 228 illus., 196 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031257759
    DDC: 580
    Language: English
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  • 95
    Keywords: Cardiovascular system. ; Physiology. ; Biomedical engineering. ; Heart Surgery. ; Cardiology. ; Cardiovascular Physiology. ; Biomedical Engineering and Bioengineering. ; Cardiac Surgery. ; Cardiology.
    Description / Table of Contents: ANATOMY, PHYSIOLOGY, CONGENITAL DEFECTS, and DISEASE. - The anatomy and function of the atrioventricular valves -- The anatomy and function of the semilunar valves -- Congenital heart defects that include cardiac valve abnormalities -- Acquired valve disease and processes -- Complex repair of CHD requiring conduits OR valve replacement outside of the ROSS procedure -- VALVE REPAIR AND REPLACEMENT -- Heart valve disease -- History of heart valve repair -- The Ross Procedure -- The Use of Echocardiographic imaging of Valves -- Advanced 3D imaging (CT and MRI) and transcatheter valve repair/ implantation -- Transcatheter mitral repair and replacement -- Percutaneous pulmonary valve implantation: the first transcatheter valve -- Transcatheter aortic valve implantation -- Post TAVR PCI -- Complex Procedures in TAV, SAV, HARPOON, BASILICA w/ case studies -- Tissue engineered heart valves -- New trends for valve replacement like the Ozaki procedure -- Post-operative management of valves: On-X valve in post anticoagulation management -- TESTING, REGULATORY and TRAINING ISSUES -- In vitro testing of heart valve substitutes -- Numerical methods for design and evaluation of prosthetic heart valves -- Animal models for cardiac valve research -- The use of isolated heart models and anatomic specimens as means to enhance the design and testing of cardiac valve therapies -- Successful development and regulatory approval of replacement cardiac valves -- Clinical trial requirements for cardiac valves -- Virtual Prototyping and 3D Printing For Simulation -- Computational Modeling, Validation, Verification and Uncertainty: Device simulation in Valvular Anatomies -- Procedural Training and Education: Mixed Realities.
    Abstract: This state-of-the-art handbook is dedicated to cardiac valve anatomy, models for testing and research methods, clinical trials; and clinical needs and applications. In this new edition, chapters are updated with the latest research in addition to new chapters on complex repair of CHD requiring conduits, new trends for valve replacement like the Ozaki procedure, as well as complex procedures in TAV, SAV, HARPOON, and BASILICA, with case studies for each type of procedure. This volume serves as a helpful reference for patients, educators, students, device designers and developers, clinical study specialists, clinicians, and other associated healthcare providers.
    Type of Medium: Online Resource
    Pages: XVII, 615 p. 252 illus., 206 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031255410
    DDC: 573.1
    Language: English
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  • 96
    Keywords: Food science. ; Food security. ; Food Analysis. ; Chemistry. ; Food Science. ; Food Security. ; Food Engineering. ; Food Studies. ; Food Chemistry.
    Description / Table of Contents: Entomophagy in 3D Food Printing -- Entomophagy and its Application through 3D Printing for Sustainable Food Development -- Crickets as a promising alternative edible insect: nutritional and technological aspects and 3D printing prospective -- Insects Nutrition And 3D Printing -- Entomophagy: Application of Edible Insects in 3D Printed Foods -- Edible Insects as Materials for Food Printing: Printability and Nutritional value -- Drosophila as a Potential Functional Food: An Edge over other Edible Insects -- 3D printing, insects and food: a bibliometric analysis -- Inkjet-based 3D food printing for sustainable insect materials: A state-of-the-art review and prospective materials -- Extrusion-based 3D printing concept in customized nutritional products -- A Review on Binder jetting and Selective Laser Sintering: a novel assessment of the processes for 3D Insect food printing materials -- Social, Economic, Scientific and Environment Aspects of Entomophagy in 3D Food Printing.
    Abstract: This book compiles a diverse and interdisciplinary range of scientific literature, laboratory developments, industrial implications and future prospects covering Entomophagy in 3D food printing to fight against hunger and nutritional deficiencies. Recent developments in Entomphagy in 3D printing of Drosophila based materials, and their nutritional, social, economic, scientific and environmental aspects. are comprehensively covered. Readers will also find shortcomings, guidelines, and industrial prospects for these materials, with emphasis on processing methods for the extraction of sustainable materials through 3D food printing. 3D Printing of Sustainable Insect Materials focuses on the methodology, technology and processing used for utilizing insects in 3D food printing applications, establishing technology-driven knowledge to fight against hunger. Chapters cover the principles for Entomophagy, insect processing methods, modern 3D food printing technologies, and the theoretical and practical aspects of Emtomophagy in 3D printing, with a special focus on future prospects and technologies. This ground-breaking book will serve knowledge to researchers and industry professionals across the food industry with broad coverage of emerging technologies, materials developed through Entomophagy, functional characterization and the technical details required to produce sustainable insect-based materials through 3D food printing. .
    Type of Medium: Online Resource
    Pages: VIII, 206 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031259944
    DDC: 641.3
    Language: English
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  • 97
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Medical sciences. ; Drug development. ; Medicine Research. ; Biology Research. ; Pharmaceutical chemistry. ; Biometry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Biomedical Research. ; Pharmaceutics. ; Biostatistics. ; Medical Toxicology.
    Description / Table of Contents: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.
    Abstract: This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.
    Type of Medium: Online Resource
    Pages: XII, 111 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031287602
    DDC: 615
    Language: English
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  • 98
    Keywords: Bioethics. ; Medicine Research. ; Biology Research. ; Biomedical engineering. ; Medical sciences. ; Drug development. ; Clinical medicine Research. ; Environment. ; Bioethics. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Preclinical Research. ; Clinical Research. ; Environmental Sciences.
    Description / Table of Contents: Foreword - Peter Singer -- Introduction: Biomedical Research in One World: Current and Future Challenges -- Part I - Biomedical Research -- Section One - Genetic and Cell Research -- Chap 1: Learning from Icarus: The Impact of CRISPR on Gene Editing Ethics -- Chap 2: Bioethical Decision Making and Genome Editing -- Chap 3: Therapeutic Genome Editing -- Chap 4: Bioethical Decision-Making about Somatic Cell Genome Editing: Sickle-Cell Disease as a Case Study -- Chap 5: Gene Therapy and Germline Cells Research -- Chap 6: Bioethical Quandaries in Preimplantation Genetic Diagnosis -- Chap 7: Rare Disease Research -- Chap 8: Limits of Debate: Governance of Human Embryo Research and the Making of the Fourteen-Day Rule -- Chap 9 Human/Non-Human Chimeras -- Chap 10: Human Cloning: Recent Advances and Bioethical Issues -- Section Two - Enhancement Research -- Chap 11: The Evolutionary Optimality Challenge -- Chap 12: Mood Enhancement -- Chap 13: Superior Sport Performance: Ethical and Legal Issues -- Chap 14: Arguments over Life Extension in Contemporary Bioethics -- Section Three - Research with Human Biological Samples and Health Data -- Chap 15: Research with Human Biological Samples. Systematization of the Phases and Affected Rights -- Chap 16: Biobanks for Biomedical Research: Evolution and Future -- Chap 17: Biobanking in Global Health & Research -- Chap 18: Ethical and Legal Considerations in Genomic Data Sharing: Evolution of the Discourse and the Road Ahead -- Section Four - Biomedical Challenges in Research -- Chap 19: Human Challenge Trials in Pandemics: Risks and Benefits -- Chap 20: Ethical Considerations for Vaccine Research -- Chap 21: Global Health Partnerships and Emerging Infectious Disease -- Chap 22: Precision Medicine -- Chap 23: The Development, Implementation, and Oversight of Artificial -- Intelligence in Health Care: Legal and Ethical Issues -- Part II - Animals, Food and Environment -- Section One - Using Animals in Scientific Research -- Chap 24: The Use of Animals in Basic Biological Research -- Chap 25: The Use of Animals in the Study of Human Disease: Key Roles of General Ethical Principles -- Chap 26: Ethical Issues Concerning Genetically Modified Animals for the Study of Human Diseases -- Chap 27: Of Mice-Rats and Pig-Men: Ethical Issues in the Development of Human/Nonhuman Chimeras -- Chap 28: Animals in Research in Pharmaceutical Industry -- Chap 29: Animal Use in Toxicity Studies -- Chap 30: Ethical Issues from the Use of Animals in the Cosmetics and Fashion Industries -- Chap 31: Is it Time to Phase Out the Use of all Nonhuman Primates in Invasive Research? -- Chap 32: Growing Human Organs Inside Animals -- Chap 33: Animal Cloning -- Section Two - Decision Making and Alternatives to Animal Use in Research -- Chap 34: Replacement, Reduction and Refinement -- Chap 35: Integrating Human and Nonhuman Research Ethics -- Chap 36: Regulation of Animal Research -- Section Three - GMOs for Global Challenges -- Chap 37: Ethical Issues in Genetically Modified Foods: From Transgenesis to CRISPR-Cas9 Genome Editing Technology -- Chap 38: GMOs and Human and Environmental Safety -- Chap 39: GMOs and Sustainable Agriculture.
    Abstract: The Handbook of Bioethical Decisions is aimed at addressing and analyzing the most important ethical concerns and moral quandaries arisen in biomedical and scientific research. As such, it identifies and problematizes on a comprehensive range of ethical issues researchers must deal with in different critical contexts. Thus, the Handbook, Vol. I, may be helpful for them to make decisions and deliberate in complex practical scenarios. In this fashion, the volume reunites different points of view to give readers room enough to get a better knowledge and take their own position on pressing bioethical issues of the day. Consequently, this work seeks to engender dense ethical epistemology scientists can count on when conducting latest generation biomedical research. By bringing together an impressive array of contributions on the most important elements and categories for “at the bench” bioethical decisions as well as offering chapters by some of the most world renowned and prominent experts in bioethics, the Handbook, Vol. I, is a paradigmatic text in its area and a valuable resource for courses on bioethics, and biomedical research, as well as courses that discuss ethics and the biosciences at different professional levels, biomedical industry, pharmacological companies and the public sphere in general. .
    Type of Medium: Online Resource
    Pages: XX, 778 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031294518
    Series Statement: Collaborative Bioethics, 2
    DDC: 174.2
    Language: English
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  • 99
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Aging. ; Medicine Research. ; Biology Research. ; Public health. ; Biotechnology. ; Psychiatry. ; Ageing. ; Biomedical Research. ; Public Health. ; Chemical Bioengineering. ; Psychiatry.
    Description / Table of Contents: Senescence opposed to longevity -- Genetics, the language of Proteomics -- Plants Uncover Senescence Animals Way Off Humans -- Rejuvenation stops Senescence -- Overlap of Senescence with Disease -- Mosaic Restricted to the Individuum -- Remaining Time until Death -- Laboratory Checkups -- eroprotectors.
    Abstract: This book is about lifelong ageing of humans. The basic biochemical and genetic mechanisms remain ill known, and differ among individuals. The book starts out to explore the plant and animal kingdoms to answer questions human ageing needs for understanding. First, we come to scrutinize time running out and what ‘normal’ means with impacts on the genome and on protein half- lives and function. Ageing goes beyond biochemical skid treated by geroprotector drugs, including biosimilars; albeit early diagnosis with standard medical laboratory assays, here addressed, sheds light with focus on basic research. Modern tools, including machine learning, and DNA technology, e.g. genomics, have already provided for unanticipated insights. The chapters then turn around senescence of the entire organism based on variable ageing of single organs embedded in neuronal networks . Psychological stress factors, dementia opposed to vigilance, and distinction of ageing from overt disease are contrasting in humans and are opposed in the book. Senescence, seen as a one way track may be reverted into rejuvenation, made possible by insights into immunosenescence and genomic approaches. Risk management in health insurance finds important clues in this book. The topics addressed between the book covers help to understand the trend to the ever- prolonging life expectancy beyond the centenarian age group; nursing care takers and pharmaceutical industry are invited to understand what’ is going on in senior people to make their geriatric population remain fit or become frail.
    Type of Medium: Online Resource
    Pages: XXIII, 132 p. 38 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031322761
    DDC: 571.878
    Language: English
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  • 100
    Keywords: Biodiversity. ; Ecology . ; Biotic communities. ; Population biology. ; Urban ecology (Biology). ; Biodiversity. ; Ecology. ; Community and Population Ecology. ; Urban Ecology.
    Description / Table of Contents: Part 1. Biocultural Landscapes During the Anthropocene -- Chapter 1. Understanding Plant Diversity Dynamics in Biocultural Landscapes During The Anthropocene -- Chapter 2. Building Sustainability in Community-Managed Mangrove Forest using Biocultural Approach to Conservation -- Chapter 3. Plant Diversity in Biocultural landscapes during Anthropocene: The Need For Conservation, Challenges, and Future Prospects in Today’s World -- Chapter 4. Extinction of Medicinal Plants in Anthropocene Epoch: Special Reference to Rauwolfia Serpentina -- Part 2. Keystone and Other Significant Species in Bicultural Landscapes -- Chapter 5. Ethnobotany of Yams (Dioscoreaceae) Used by Local Communities in the Northwest of Luzon Island -- Chapter 6. A Preliminary Survey of The Genus Hoya R.Br. (Apocynaceae) in Papua, Indonesia with Notes on Hoya as Larval Food plant of Euploea netscheri Snellen -- Chapter 7. Species Diversity and Habitat Association of Ferns and Lycophytes in Mts. Palay-Palay Mataas na Gulod Protected Landscape -- Chapter 8. Remaining Subpopulations of Impatiens Manillensis Walp. 1843 (Balsaminaceae) In Mts. Palay-Palay-Mataas-Na-Gulod Protected Landscape, Luzon Island, Philippines -- Chapter 9. Pteridophytes in Mount Matutum Protected Landscape -- Chapter 10. Morphological Diversity of Kopyor Coconut in Indonesia -- Chapter 11. Ecology of Understory Plants of Forests over Limestone in Samar Island, Philippines -- Chapter 12. Taxo-ethnobotany of Genus Ficus l. In Jammu and Kashmir State (India) -- Part 3. Ecosystem Prcesses in Bicultural Landscapes -- Chapter 13. Food to Medicine: The Impact of Soil and Climatic Factors on the Phytochemical Property of Anahaw (Saribus rotundifolius (Lam.) Blume Shoot -- Chapter 14. Floral and Fruiting Phenology in the Lowland Forests of Palanan, Isabela, Philippines -- Chapter 15. A Survey of Understory Vegetation in the Biocultural Landscape of Mount Makiling, Luzon Island, Philippines: Implications for Sustainable Management -- Chapter 16. Floral Diversity and Carbon Stock Assessments of Montane Forests Along the Tri-Boundaries of Benguet, Ifugao and Mountain Province, Philippines -- Chapter 17. The Dynamics of Soil Microbiome Upon Anthropogenic Changes In Plant Diversity and Land Management Practices -- Chapter 18. Plants' anatomical and genetic responses to anthropogenic climate change and human-induced activities -- Chapter 19. Impact of Anthropogenic compounds on biodiversity: A comprehensive analysis -- Part 4. Best Practices in Plant Diversity Conservation -- Chapter 20. Documentation of the Phenocalendar of Allaeanthus luzonicus (Blanco) Fern.-Vill. (Family Moraceae) to Sustain Its Utilization -- Chapter 21. Analyzing the Spatio-Temporal Changes of the Biocultural Landscape of Banaue, Philippines Using GIS -- Chapter 22. Plant Diversity in Selected Agro- and Forest Ecosystems in Indigenous Cultural Communities (ICCs) in the Cordillera Region, Northern Philippines -- Chapter 23. The Stories of Organic Farming Champions in the Philippines and their Crop Diversity Practices -- Chapter 24. Current status of Seaweed diversity: Anthropogenic interventions -- Part 5. Emerging Frameworks for Conservation -- Chapter 25. Homegarden Agroforestry for Plant Diversity Conservation in an Urban Landscape: Practices and Prospects -- Chapter 26. Comprehending the cultural landscape of Mount Makiling: a road to Community Wellbeing necessary to enhance ecosystem integrity -- Chapter 27. System Dynamic Modelling of Top Harvested Plant Bioresources in Northern Negros Natural Park -- Chapter 28. Heritage Negotiations in Manila and Pampanga: The Use of Toponyms in the Study of Two Biocultural Landscapes in the Philippines -- Chapter 29. Liaforestry-sustainable Forest Management Model Using Multi-Purposes Tree Species for Reforestation and Climate Change Mitigation, Lesson Learned from Meru Betiri National Park -- Chapter 30. Conservation of IUCN Threatened Zingiberaceae Species in Tropical Asia: Challenges, Gaps and Opportunities.
    Abstract: The edited book highlights comprehensive studies on plant diversity dynamics, ecosystem processes, and best conservation practices from the interdisciplinary perspectives such as the botanists, ecologists, conservation biologists, geneticists, cell biologists, molecular biotechnologists, and social scientists. The main focus of the book is to address biodiversity loss and ecosystem collapse amidst the escalating climate change problems, aggravated by anthropogenic activities in biocultural landscapes. The book describes the biocultural landscape of today, ecology of plant diversity, botany of keystone and other rare species of economic and pharmaceutical significance, ecosystem processes, conservation, and emerging frameworks to sustain biocultural landscapes in the Anthropocene. Biocultural landscapes are tracks of land in many parts of the world, shaped by unique human-nature interactions. Many of these landscapes are populated with indigenous peoples with a unique way of life including their interaction with plants and the environment. The relationship between humans and nature in biocultural landscapes used to be harmonious. However, as the human population surges, much pressure has been experienced by the landscape, hence, the loss of biodiversity and degradation of ecosystem services that cascade to agricultural systems. The book is of interest to teachers, professors, policymakers, researchers, and advocates in the fields of botany, ecology, taxonomy, biodiversity conservation, environmental science, molecular biology and genomics, molecular ecology, agriculture, and Agri-tourism, forestry, social science, and climate change professionals. Also, the book serves as a good reference and additional reading material for undergraduate and graduate students.
    Type of Medium: Online Resource
    Pages: IX, 724 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811986499
    DDC: 333.95
    Language: English
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