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Digitale Medien

Probing the activation-promoted structural rearrangements in preassembled receptor–G protein complexes (2006)

Galés, Céline ; Van Durm, Joost J J ; Schaak, Stéphane ; [weitere]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 778-786

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ISSN: 1545-9985

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Activation of heterotrimeric G proteins by their cognate seven transmembrane domain receptors is believed to involve conformational changes propagated from the receptor to the G proteins. However, the nature of these changes remains unknown. We monitored the conformational rearrangements at the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsmb1134

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2

Digitale Medien

Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells (2006)

Listerman, Imke ; Sapra, Aparna K ; Neugebauer, Karla M

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 815-822

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ISSN: 1545-9985

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Coupling between transcription and RNA processing is a key gene regulatory mechanism. Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation of the precursor mRNA (pre-mRNA) splicing factors hnRNP A1, U2AF65 and U1 and U5 snRNPs on the intron-containing human FOS ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsmb1135

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3

Digitale Medien

The Swi5–Sfr1 complex stimulates Rhp51/Rad51 - and Dmc1-mediated DNA strand exchange in vitro (2006)

Haruta, Nami ; Kurokawa, Yumiko ; Murayama, Yasuto ; [weitere]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 823-830

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ISSN: 1545-9985

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nucleoprotein filaments made up of Rad51 or Dmc1 recombinases, the core structures of recombination, engage in ATP-dependent DNA-strand exchange. The ability of recombinases to form filaments is enhanced by recombination factors termed 'mediators'. Here, we show that the Schizosaccharomyces pombe ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsmb1136

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4

Digitale Medien

Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions (2006)

Didiano, Dominic ; Hobert, Oliver

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 849-851

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ISSN: 1545-9985

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We use Caenorhabditis elegans to test proposed general rules for microRNA (miRNA)-target interactions. We show that G·U base pairing is tolerated in the 'seed' region of the lsy-6 miRNA interaction with its in vivo target cog-1, and that 6- to 8-base-pair perfect seed pairing is not a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsmb1138

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5

Digitale Medien

A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain (2006)

Rideau, Alexis P ; Gooding, Clare ; Simpson, Peter J ; [weitere]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 839-848

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ISSN: 1545-9985

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Polypyrimidine tract–binding protein (PTB) is a regulatory splicing repressor. Raver1 acts as a PTB corepressor for splicing of α-tropomyosin (Tpm1) exon 3. Here we define a minimal region of Raver1 that acts as a repressor domain when recruited to RNA. A conserved [S/G][I/L]LGxxP motif ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsmb1137

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6

Digitale Medien

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing (2006)

Huffman, Kenneth E ; Schwartz, Jacob C ; Ram, Rosalyn ; [weitere]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 787-792

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ISSN: 1545-9985

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Duplex RNAs complementary to messenger RNA inhibit translation in mammalian cells by RNA interference (RNAi). Studies have reported that RNAs complementary to promoter DNA also inhibit gene expression. Here we show that the human homologs of Argonaute-1 (AGO1) and Argonaute-2 (AGO2) link the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsmb1140

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7

Digitale Medien

L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells (2006)

Yang, Nuo ; Kazazian, Haig H

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 763-771

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ISSN: 1545-9985

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] LINE-1s, or L1s, are highly abundant retrotransposons comprising 17% of the human genome. Most L1s are retrotransposition defective; nonetheless, there are ∼100 full-length L1s potentially capable of retrotransposition in the diploid genome. L1 retrotransposition may be detrimental to the host ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsmb1141

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8

Digitale Medien

Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells (2006)

Kim, Daniel H ; Villeneuve, Louisa M ; Morris, Kevin V ; [weitere]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 793-797

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ISSN: 1545-9985

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Argonaute proteins are the core components of effector complexes that facilitate RNA interference (RNAi). Small interfering RNAs (siRNAs) targeted to promoter regions mediate transcriptional gene silencing (TGS) in human cells through heterochromatin formation. RNAi effector complexes have yet to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsmb1142

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9

Digitale Medien

Telling it like it was (2006)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 663-664

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ISSN: 1545-9985

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] There are a number of settings where one can expect (or at least hope) to be moved—at a concert, a play or in a museum—and a scientific meeting is not typically one of them. But that is where I was, along with the rest of those who attended the 11th annual RNA Society Meeting in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsmb0806-663

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10

Digitale Medien

Helical proteins initiate replication of DNA helices (2006)

Jeruzalmi, David ; O'Donnell, Mike

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 13 (2006), S. 665-667

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ISSN: 1545-9985

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Initiation of chromosome replication requires controlled access to the DNA duplex to produce an unwound region of DNA for assembly of the replication machinery. This DNA remodeling task is performed by an initiator protein that binds at the origin and begins a cascade of events resulting in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsmb0806-665

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