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  • Nature Publishing Company
  • 1985-1989  (323)
  • 1986  (323)
  • 1
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    [s.l.] : Nature Publishing Company
    Nature biotechnology 4 (1986), S. 756-756 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—In the future, drug release may be mediated by ultrasound. This is one of the potential advantages of the bio-erodible polymer technology for drug delivery developed by Robert Langer and his associates at MIT (Cambridge, MA). The technology, recently licensed to Nova Pharmaceutical ...
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  • 2
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    Nature biotechnology 4 (1986), S. 761-761 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Sumitomo Chemical Co., Ltd. (Osaka), NEC Corp., (Tokyo) Sumitomo Pharmaceuticals, Kissei Pharmaceutical, and its subsidiary, Kissei Comtec have developed a biochemical expert system called BIOCES which uses drug receptor theory for protein engineering and design of pharmaceuticals and agricultural ...
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  • 3
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    Nature biotechnology 4 (1986), S. 764-765 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] First recombinant vaccine approved. Recombivax HB, the genetically engineered surface-antigen vaccine against hepatitis B developed by Chiron Corp. (Emeryville, CA) and Merck (Rahway, NJ) was approved for sale by the U.S. Food and Drug Administration (FDA). Merck plans to begin marketing the ...
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  • 4
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    Nature biotechnology 4 (1986), S. 753-753 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A non-medically qualified individual uses material of unknown composition and toxicity to treat patients, including a child, who may be suffering from a potentially fatal illness. The individual does not even try to obtain informed consent, but publishes patients' names and addresses to help ...
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  • 5
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    Nature biotechnology 4 (1986), S. 762-762 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] GULF BREEZE, Fla.—Although genetically engineered plants have finally gone to field tests, efforts to field-test recombinant microbes remain stymied by opposition and regulatory delays. The Environmental Protection Agency's Microbial Ecology and Biotechnology Branch here is trying to develop ...
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  • 6
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    Nature biotechnology 4 (1986), S. 767-767 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SCHENECTADY, N.Y.—Protein engineers could soon have a new technique to help them analyze crystal structures. The method, developed by General Electric staff biophysicist Egidijus E. Uzgiris and collaborators, allows visualization of the overall configuration of a protein sample ...
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  • 7
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    Nature biotechnology 4 (1986), S. 681-681 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Before we lose sight of our good fortune amidst the freneticism of patents, probes, and what Spyros Andreopoulos calls “gene cloning by press conference” (See New England Journal of Medicine 302:743, 1980), let's pause and remember one thing. Microbiology is young. Measured alongside ...
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  • 8
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    Nature biotechnology 4 (1986), S. 688-688 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON—Fall-out is beginning from the European Parliament's highly controversial decision to outlaw the use of steroid hormones in animal husbandry (see Bio/Technology 4:255, April '86). This ruling led the Commission of the European Economic Community (EEC) in Brussels to release a directive ...
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  • 9
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    Nature biotechnology 4 (1986), S. 694-694 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] RALEIGH, N.C.—The commercial poultry industry is worth a fortune. Individually, however, chickens are worth next to nothing. In fact, they are the very sort of high-volume, low-value products that biotechnologists habitually shun. So, while a number of bovine-oriented genetic engineering ...
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  • 10
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    Nature biotechnology 4 (1986), S. 706-711 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] One sure sign of a rapidly developing field is when the next generation of products is approaching the clinic before the current generation makes it to the marketplace. This is true throughout biotechnology, but nowhere is it so evident as for the blood clot dissolver called tissue plasminogen ...
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  • 11
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    Nature biotechnology 4 (1986), S. 605-605 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] STONY BROOK, N.Y.—What are the features of messenger RNA-30S ribosome interaction that lead to efficient translation? New insights into this question were offered at this year's Stony Brook Symposium on Molecular Biology. One group, headed by Larry Gold at the University of Colorado ...
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  • 12
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    Nature biotechnology 4 (1986), S. 598-598 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Thomas Kuhn's scenario of scientific revolutions, setting new paradigms for interludes of “normal science,” sometimes seems an appropriate model to describe the evolution of technology too. For medical diagnostics, the mid-1980s is such a time of Kuhnian revolution—a period in ...
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  • 13
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    Nature biotechnology 4 (1986), S. 483-487 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] VALLEY FORGE, Pa.—Coincident with the complexities of eucaryotic gene organization are possibilities for manipulating its components. Such manipulations can be both dramatic and informative. This was clear from results presented at the Fourth Annual Smith Kline & French Laboratories ...
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  • 14
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    Nature biotechnology 4 (1986), S. 607-607 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Glasgow—A Human Leukaemia Virus Centre, the first of its kind in the world, is being established here at the University of Glasgow. Supported by funds of almost £2 million over the next five years, it will be located in the department of veterinary pathology, where William Jarrett has ...
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  • 15
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    Nature biotechnology 4 (1986), S. 622-622 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Lymphokines. have always been the glamor-child of biotechnology. First, interferon bore the standard for a promising but fledgling industry. When this biological response modifier seemed to lose some of its magic in the clinic, another lymphokine, interleukin-2 (IL-2), stepped into the ...
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  • 16
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    Nature biotechnology 4 (1986), S. 656-658 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Tangential flow sampler/concentrator. Control Equipment Corp.'s (Lowell, MA) Radial Flow Filter Module is based on a tubular ceramic filter cartridge of 0.2 micron pore size. Fluid is pumped parallel to the filter surface where a pressure differential forces fluid across the filter barrier. Write ...
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  • 17
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    Nature biotechnology 4 (1986), S. 659-659 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Pressure drop. Technical Notes 7 from Rheodyne (Cotati, CA) allow one to predict the pressure drop caused by injectors, valves, and tubes in a preparative LC system. Write in 701 on Reader Service Card Packaging and shipping. American Type Culture Collection (Rockville, MD) has just published a ...
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  • 18
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    Nature biotechnology 4 (1986), S. 662-662 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: When Bernard Dixon deals with the European Patent Convention (Feb. '86), he misses certain points which make the situation far more complex than the simple “EPC is wrong and must be overhauled” attitude implies. First is the question of deposit. I thoroughly agree with ...
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  • 19
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    Nature biotechnology 4 (1986), S. 481-481 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Three solid days on the ecology of biological invasions, the first two within the portals of the Royal Society and the other by courtesy of London's Ciba Foundation, sound like a formula for intensive cerebration. Contemplating this tandem of meetings, as I did recently, was enough to suggest a ...
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  • 20
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    Nature biotechnology 4 (1986), S. 495-495 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] New government approvals for biotechnology products include a pesticide field-test go-ahead and two medical marketing permissions. The U.S. Environmental Protection Agency will allow Steven Lindow of the University of California (Berkeley) to perform field tests on recombinant Pseudomonas bacteria ...
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  • 21
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    Nature biotechnology 4 (1986), S. 500-500 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Sumitomo Chemical Co. (Osaka) has developed a commercially applicable mass-production technology for a human monoclonal antibody. The antibody attacks pyocyanic bacillus exotoxins and can be produced through EB-Virus transformation. Sumitomo is also planning construction of Japan's largest safety ...
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  • 22
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The goal of the National Laboratory Gene Library Project at the Los Alamos and Lawrence Livermore National Laboratories is the production of chromosome–specific human gene libraries and their distribution to the scientific community for studies of the molecular biology of genes and ...
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  • 23
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    Nature biotechnology 4 (1986), S. 461-461 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Eliminate hand covers lipping. Histologists, cytologists, and others who need coverglasses placed precisely on microscope slides will benefit from this new 4-page brochure describing the Hacker-Meisei (Fairfield, NJ) Robot Coverslipping Machine. Write in 700 on Reader Service Card Calibration ...
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  • 24
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    Nature biotechnology 4 (1986), S. 379-379 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] CAMBRIDGE, U.K.—Hot competition is expected for ownership of Britain's National Seed Development Organisation (NSDO). Together with part of the nearby Plant Breeding Institute (PBI), NSDO is the latest of several publicly owned bodies to be “privatized” under the Thatcher ...
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  • 25
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    Nature biotechnology 4 (1986), S. 382-382 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—McDonnell Douglas Astronautics' (St. Louis, MO) plans to develop and market erythropoietin (EPO) produced aboard the space shuttle have ground to a halt. Discussions (often reported in the press as an agreement) between McDonnell Douglas and 3M's Riker Laboratories division ...
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  • 26
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    Nature biotechnology 4 (1986), S. 395-401 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fermentation per se is an expensive process. In fact, it is this expense that has so far prevented the spread of biotechnology very far beyond the pharmaceutical field, into commodity and specialty chemicals. In these traditional industries, fermentations are used only to the extent that chemical ...
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  • 27
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    Nature biotechnology 4 (1986), S. 293-296 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotechnology seems to be at a point in its history which requires another step up in the quality of information about the various goings-on in bioland. This paper reports on efforts to improve both the precision and completeness of our knowledge of the non-governmental financing of biotechnology ...
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    Nature biotechnology 4 (1986), S. 297-303 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Optimal application of protein engineering technology will require understanding how the amino acid sequence of a polypeptide chain specifies its spatial conformation. It is now clear that polypeptide chain folding and subunit assembly proceeds through sequential pathways involving defined ...
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  • 29
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    Nature biotechnology 4 (1986), S. 352-352 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Plastic ware. This 96-page 1986 catalog from Cole-Parmer Instrument (Chicago, IL) lists laboratory ware in 36 categories, from bags to vials, with application guides for selecting resins, chemical resistance, and care. Write in 701 on Reader Service Card Coated tissue-culture labware. The Matrex ...
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  • 30
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    Nature biotechnology 4 (1986), S. 159-159 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Bernard Dixon's article, “What Happened to Detail and Discussion?” (December 1985) pointed out a difficulty of applied scientists (micro-biologists) in reporting and discussing their work in public. However, he is wrong in his diagnosis that this is a new problem. The ...
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    Nature biotechnology 4 (1986), S. 255-255 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Irrationality has won the day. Despite the British Veterinary Association's valiant efforts, which I described last month, to educate the public and the politicians about hormones, the use of these substances as animal growth promoters is to be prohibited throughout the European Community. ...
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  • 32
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    Nature biotechnology 4 (1986), S. 265-266 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] HAVANA—The Center for Biological Research (GIB) here is a visible embodiment of Cuba's decision to make biotechnology development a number one national priority. Organized much like genetic engineering companies in the United States, the Center has laboratories for in vitro gene ...
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  • 33
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    Nature biotechnology 4 (1986), S. 177-177 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON—Britain's major biotechnology company, Celltech Ltd., is seeking to increase its presence abroad. With some 90 percent of its sales already coming from outside the U.K., Celltech (Slough, U.K.) has formed an American subsidiary. Actually owned by the Boots-Celltech Diagnostics Ltd. ...
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  • 34
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Mouse pancreatic α–amylase complementary DNA was inserted into a yeast shuttle vector after the Saccharomyces cerevisiae MFα1 promoter and secretion signals coding sequences. When transformed with the recombinant plasmid, S. cerevisiae cells were able to synthesize and secrete ...
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    Nature biotechnology 4 (1986), S. 344-348 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Scanning electron microscope. The S-900 from Hitachi Scientific Instruments is claimed to be the world's highest-resolution ESM—guaranteed at 8Å at 30 KV. The device is marketed by Nissei Sangyo America (Mountain View, CA). Write in 600 on Reader Service Card Water purification ...
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    Nature biotechnology 4 (1986), S. 157-157 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Three years ago this month, Nature published the first issue of its new industrial journal, Bio/Technology. This issue, then, marks our leather anniversary, the inauguration of the journal's second Scientific Advisory Board, and the first report from our first scientific conference. This is a ...
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    Nature biotechnology 4 (1986), S. 161-161 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A few months ago, the British Veterinary Association (BVA) found it necessary to issue a statement headed “Hormones and Antibiotics—There Is a Fundamental Difference,” which explained the contrasting nature of these two groups of naturally-occurring compounds. A non-commercial ...
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    Nature biotechnology 4 (1986), S. 170-170 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] SAN FRANCISCO—Biotechnology companies were impressively represented at the Fourth Annual Ham-brecht & Quist Health Care Conference, held here in January. Amid the euphoria that comes with products on the market and soaring stock prices, two of the most impressive presentations were made ...
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    Notes: [Auszug] Accurate identification of persons exposed to the human AIDS (acquired immunodeficiency syndrome) retrovirus is important in screening asymptomatic blood donors and in clinical situations related to AIDS. Assays for antibodies to the virus that employ antigens derived from virus-infected lymphoid ...
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    Nature biotechnology 4 (1986), S. 134-137 
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    Notes: [Auszug] A facile method for activating hydroxyl groups of Sepharose gel using 2-fluoro-1-methylpyridinium toluene-4-sulfonate (FMP) in the presence of triethylamine is described. Nucleophilic affinity ligands, i.e., primary amino or sulfhydryl bearing compounds in slightly alkaline (pH 8-9) aqueous ...
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    Nature biotechnology 4 (1986), S. 10-10 
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    Notes: [Auszug] CHAPEL HILL, NC—Is there a business in supplying rare and potentially useful fungi? A start-up company here called Mycosearch thinks so, and it is the only firm in the world to provide such a service. Barry Katz started Mycosearch in 1979, but the fungus company remained in a vegetative ...
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    Nature biotechnology 4 (1986), S. 17-17 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] STOCK PRICES OF SELECTED BIOTECHNOLOGY SPECIALTY FIRMS Price July 9, 1985 Price Dec. 9, 1985 Percent Change 52 Week Hi-Low Market Capitalization o in $ millions (stock price × number of shares outstanding) Companies Emphasizing Recombinant DNA Technology Advanced Genetic ...
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    Nature biotechnology 4 (1986), S. 69-69 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The Bioactive Peptides Catalog available from Sigma (St. Louis, MO), highlights over 400 peptides, including chemotactic peptides, enzyme inhibitors, endorphins, and angiotensin. Write in 701 on Reader Service Card An inexpensive scanning electron microscope is highlighted in a brochure available ...
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    Nature biotechnology 4 (1986), S. 783-785 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Open-pollinated seeds were denied regular (utility) patent protection for nearly 200 years. Not until 1930 did asexually propagated plants receive patent protection (under the Plant Patent Act); and sexually propagated plants, transplants, and seeds finally received some protection in 1970 under ...
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    Nature biotechnology 4 (1986), S. 786-789 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Commercially important antibiotics are produced by several classes of organisms including many of the actinomycetes (Streptomyces, Actinomadura, Actinoplanes, Micromonospora, and Nocardia species), bacilli and fungi (Cephalosporium and Penicillium species). Antibiotics can be purified from ...
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    Nature biotechnology 4 (1986), S. 809-811 
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    Notes: [Auszug] Retracting microtome. Hacker Instruments (Fair-field, NJ) offers the new Hacker-Bright “5030” Rotary Microtome for sectioning both paraffin and plastic embedded material. Retraction, motor drive, and interchangeable advances are featured. Write in 601 on Reader Service Card Chemical ...
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    Nature biotechnology 4 (1986), S. 686-686 
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    Notes: [Auszug] Showa Denko (Tokyo), the world's largest manufacturer of L-tryptophan and other amino acids and peptides, has appointed Siber Hegner as sole U.K. distributor for its products, including L-tryptophan, 5-hydroxy-L-tryptophan, L-tyrosine, and D-amino acids. Oriental Yeast Co., Ltd. (Tokyo) and Nagase ...
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    Nature biotechnology 4 (1986), S. 696-697 
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    Notes: [Auszug] Products to the market, the field, and the clinic. Ortho Pharmaceutical Corp.'s (Raritan, NJ) OKT3 monoclonal antibody was approved by the U.S. Food and Drug Administration (FDA) for use in reversing kidney transplant rejections (see Bio/Technology 3:961, Nov. '85). Ciba-Geigy (Research Triangle ...
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    Nature biotechnology 4 (1986), S. 712-716 
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    Notes: [Auszug] Most of the purification schemes used to ready today's commercial bio-tech products for market introduction are understandably proprietary. Still, all Cromatographic separation schemes have certain common objectives—to obtain the required degree of purity, to obtain a sufficient quantity of ...
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    Nature biotechnology 4 (1986), S. 731-733 
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    Notes: [Auszug] Xylan exists in many plants in an acetylated form, a circumstance largely neglected in studies of its breakdown by microbial enzymes. The present investigation demonstrates that fungal esterase and xylanase activities act cooperatively in hydrolyzing acetyl xylan. In the absence of esterase, ...
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    Nature biotechnology 4 (1986), S. 734-736 
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    Notes: [Auszug] Gel electrophoresis apparatus. Bethesda Research Labs (Gaithersburg, MD) offers its Model S2 electrophoresis chamber, featuring an aluminum plate for even heat distribution as well as sharkstooth combs and 0.4 mm side spacers that allow full use of 48 lanes. Write in 601 on Reader Service Card ...
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    Nature biotechnology 4 (1986), S. 597-597 
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    Notes: [Auszug] The subject, for a moment, was longbows. The occasion was a roundtable dinner for ten in London, during Biotech '86. And while the group was admirably equipped to debate the strengths and weaknesses of European biotechnology (a transcript of that discussion will appear here soon), we were ...
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    Nature biotechnology 4 (1986), S. 662-662 
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    Notes: [Auszug] To the editor: In January's issue, the article on “USDA Sows Seeds for Its Future,” states: “According to ARS, every year the United States produces more than 100 tons of surplus raw agricultural products.” Several zeroes should be added to the “100.” For ...
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    Nature biotechnology 4 (1986), S. 607-607 
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    Notes: [Auszug] The paper in this issue by Pramod Gupta and Don Durzan (University of California, Davis) on somatic polyembryony in sugar pine describes one of the few successes in generating somatic embryos, and in large number, in gymnosperm tissue culture. Furthermore, the team's suspension cultures were ...
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    Nature biotechnology 4 (1986), S. 496-497 
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    Notes: [Auszug] NEW YORK—As genetically altered products get closer to field trials, the public's perception of biotechnology is becoming critical again. In fact, not since the pioneer biotech companies successfully convinced Cambridge, MA, to allow rDNA research has the man-on-the-street stood so ...
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    Nature biotechnology 4 (1986), S. 503-503 
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    Notes: [Auszug] NEW YORK—Initial public offerings (IPOs) are the order of the day for biotechnology companies. “It's 1983 revisited,” says Steven Zimmer, vice president of Eberstadt-Fleming (New York, NY). “The window is wide open and all the companies are filing. And that's what they ...
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    Nature biotechnology 4 (1986), S. 519-521 
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    Notes: [Auszug] Affinity chromatography is a well established technique that continues to find new applications. It is used not only in the classical manner for isolating and purifying proteins, but also in new and novel ways, such as immobilizing ligands to study the kinetics of biological interactions. Many ...
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    Nature biotechnology 4 (1986), S. 533-536 
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    Notes: [Auszug] The ability to regenerate plants from poplar cells cultured in vitro suggests that poplars may prove a valuable model system for the application of recombinant DNA technology to deciduous trees. We report here the transformation of a hybrid Populus trichocarpa × deltoides with two strains of ...
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    Nature biotechnology 4 (1986), S. 592-592 
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    Notes: [Auszug] With the possible exception of nuclear energy, no other major scientific issue has generated as much interest or controversy as recombinant DNA research and biotechnology. The agricultural, medical, and financial prospects of rDNA technology have been fully explored in the popular media even if the ...
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    Nature biotechnology 4 (1986), S. 380-380 
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    Notes: [Auszug] The discovery of a new human T-lymphotropic virus, which might be the progenitor of HTLV-III, was reported by Max Essex of the Harvard School of Public Health at the recent American Society for Microbiology meetings. Designated HTLV-IV, the virus was isolated from healthy individuals in Senegal. It ...
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    Nature biotechnology 4 (1986), S. 385-385 
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    Notes: [Auszug] NEW YORK—It is not news that America's small farmers are in financial trouble. That biotechnology will add to this problem, however, is the message of a new report from the Office of Technology Assessment (OTA). Called Technology, Public Policy, and the Changing Structure of American ...
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    Nature biotechnology 4 (1986), S. 392-393 
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    Notes: [Auszug] WASHINGTON, D.C.—The widespread use of human monoclonal antibodies for treating disease hinges on producing large quantities of the appropriate antibody molecules efficiently and economically. Currently, mouse monoclonal antibodies have been used to a limited extent in therapeutic trials. The ...
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    Nature biotechnology 4 (1986), S. 419-422 
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    Notes: [Auszug] How do you detect, identify, and count bacteria in the wild? Until that basic question is answered, all debates over releasing recombinant organisms boil down to belief and educated guesswork. At the U.S. Environmental Protection Agency (EPA), charged with evaluating the “risks” posed ...
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    Nature biotechnology 4 (1986), S. 576-576 
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    Notes: [Auszug] JULY MEETINGS July 8–9. Society for General Microbiology Fermentation Group Symposium on Carbon Substrates in Biotechnology. Billingham, U.K. Info: Meetings Assistant, Society for General Microbiology, Harvest House, 62 London Road, Reading, Berks RG1 5AS, U.K. July 13–16. Microbial ...
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    Nature biotechnology 4 (1986), S. 262-262 
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    Notes: [Auszug] FORT LAUDERDALE, Fla.—High stock prices on Wall Street and high temperatures here led to an up-beat February meeting between members of the financial community and executives from biotechnology companies. The fourth annual Industrial Biotechnology Association (Rockville, MD) conference ...
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    Nature biotechnology 4 (1986), S. 427-431 
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    Notes: [Auszug] Secretion of foreign proteins from microorganisms in general and from Escherichia coli and Bacillus subtilis in particular is still a favoured option for the subsequent recovery of such proteins on a commercial scale. The variety of natural bacterial systems now being studied and the likely ...
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    Nature biotechnology 4 (1986), S. 462-462 
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    Notes: [Auszug] To the editor: We recently sent a news release announcing an achievement by scientists at United AgriSeeds, Inc. This resulted in a note in the January “Chronicle” section (p. 11). Unfortunately, the release contained a key clerical error in the lead paragraph stating that the research ...
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    Nature biotechnology 4 (1986), S. 159-159 
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    Notes: [Auszug] To the editor: I must respond to the letter from T. K. Ghose (July 1985) because it is composed solely of two inaccurate statements concerning the banning of Israeli scientists from the VIIth International Biotechnology Symposium. The meeting took place in February 1984 in New Delhi, and Dr. Ghose ...
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    Nature biotechnology 4 (1986), S. 256-257 
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    Notes: [Auszug] MIAMI—Researchers are making strides to understand interleulin-2 (IL-2) receptors in an effort to produce therapies based on this powerful lymphokine. Structure of the human IL-2 receptor gene. Numbers above the boxes refer to bases in the cDNA sequence; numbers below the boxes refer to the ...
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    Nature biotechnology 4 (1986), S. 268-271 
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    Notes: [Auszug] NEW YORK—Royalties are starting to trickle through to investors in bio technology R&D limited partnerships (RDLPs). While these payments have been minor for the most part, they indicate that at least some value exists in the technologies developed. Disaster scenarios like the Storage ...
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    Nature biotechnology 4 (1986), S. 273-275 
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    Notes: [Auszug] WASHINGTON, D.C.—Environmental release is still the burning public policy question for biotechnology. That became clear during the Brookings Institution's February conference on biotechnology, “Introduction into the Environment of Genetically Modified Organisms: A Conference on ...
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    Nature biotechnology 4 (1986), S. 219-223 
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    Notes: [Auszug] Genetic engineering of corn, and other cereals, is currently limited because of the difficulty of regenerating plants via cell culture. Here we report that commercially important inbred lines and hybrids from several different maize groups are capable of being regenerated via somatic embryos. The ...
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    Nature biotechnology 4 (1986), S. 321-324 
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    Notes: [Auszug] Cells of Escherichia coli K–12 containing a cloned fragment of Pseudomonas putida TOL plasmid pWW0 produce the dye indigo. Analysis of the cloned fragment and Tn1000 transposon insertion mutagenesis has identified the xylA gene as being responsible for this phenotype. The xylA gene specifies ...
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    Nature biotechnology 4 (1986), S. 353-353 
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    Notes: [Auszug] May Meetings May 4–7. International Symposium on Protein Engineering. Groningen, The Netherlands. Info: Secretariat, International Symposium on Protein Engineering, Laboratory of Chemical Physics, Groningen University, Nijenborgh 16, 9747 AG Groningen, The Netherlands May 5–7. 2nd ...
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    Nature biotechnology 4 (1986), S. 104-104 
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    Notes: [Auszug] Dental applications of liposomes are being researched in a collaboration between Technology Unlimited (Wooster, OH) and the Ohio State University Research Foundation. The Edison Seed Development Fund recently awarded the team $50,000 for the development of liposomes that stick to teeth and ...
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    Nature biotechnology 4 (1986), S. 171-171 
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    Notes: [Auszug] BALTIMORE, Md.—“While we have seen impressive technological improvements, I think that one has to marvel that hybridoma technology in 1986 is basically the same technology that Milstein and Kohler gave us 10 years ago,” said Joseph Davie of the Washington University School of ...
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    Nature biotechnology 4 (1986), S. 183-183 
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    Notes: [Auszug] LONDON—A. H. Robins is selling its U.K. manufacturing plant, completed less than two years ago at a cost of £9 million, to the British company Glaxo. Although the U.S. pharmaceuticals group is under pressure from lawsuits concerning its intra-uterine contraceptive (the Dalkon Shield), ...
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    Nature biotechnology 4 (1986), S. 183-183 
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    Notes: [Auszug] LONDON—The U.K. Department of Trade and Industry has provided a £1 million grant to help launch BIOTRANS, a unique association between the Laboratory of the Government Chemist (LGC) in London and the University of Kent (Canterbury), which will focus on biological transformations. ...
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    Nature biotechnology 4 (1986), S. 206-207 
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    Notes: [Auszug] Canada has not yet arrived at a national policy to guide the deliberate release of genetically engineered organisms (GEOs) into the environment. The federal Departments of Environment, Agriculture, and National Health and Welfare are responsible for protecting human health and the environment from ...
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    Notes: [Auszug] The gene encoding inosine 5′–monophosphate dehydrogenase (IMP dehydrogenase) of Bacillus subtilis was cloned in pBR322 in Escherichia coli and subsequently subcloned into the B. subtilis plasmid, pC194. The introduction of the recombinant plasmid encoding IMP dehydrogenase to B. ...
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    Nature biotechnology 4 (1986), S. 237-237 
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    Notes: [Auszug] APRIL MEETINGS April 6–12. UCLA Symposium on Interferons as Cell Growth Inhibitors and Antitumor Factors. Steamboat Springs, CO. Info: Betty Handy, UCLA Symposia, Molecular Biology Institute, University of California, Los Angeles, CA 90024 April 6–13. UCLA Symposium on Growth Factors, ...
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    Nature biotechnology 4 (1986), S. 107-112 
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    Notes: [Auszug] Recombinant DNA technology and neuroscience have joined forces in an effort to unravel the brain's mysteries. The number of neuropeptides known to exist in the brain continues to grow as a direct function of our technical sophistication. Biotechnology is perfect for designing new proteins that ...
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    Nature biotechnology 4 (1986), S. 755-756 
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    Notes: [Auszug] NEW YORK—As biotechnology therapeutics are finally wending their way to the marketplace, the dual issues of drug delivery and controlled release are becoming all the more important. Alza Corp. (Palo Alto, CA), one of the leaders in developing this technology, expects that bioerodible polymers ...
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    Nature biotechnology 4 (1986), S. 760-760 
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    Notes: [Auszug] SAN FRANCISCO—As biotechnology companies grow, more of their income is generated from product sales and less from interest, and the percentage of total spending devoted to R&D decreases. Regardless of company size, however, the growth in revenues usually exceeds the growth in expenses, ...
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    Nature biotechnology 4 (1986), S. 762-762 
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    Notes: [Auszug] CAMBRIDGE—On October 1 Sydney Brenner will exchange his post as director of the Medical Research Council (MRC) Laboratory of Molecular Biology for the directorship of a new Molecular Genetics Unit within MRC. Despite the financial hardship currently afflicting British science, MRC has found ...
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    Nature biotechnology 4 (1986), S. 780-782 
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    Notes: [Auszug] Hyaluronic acid—that molecule with the tongue-twisting name (and hence called HA)—is just the sort of high-value product that at tracts the interest of biotechnology companies. It is already used in ophthalmic surgery, and will be adapted for such diverse applications as drug delivery, ...
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    Nature biotechnology 4 (1986), S. 797-801 
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    Notes: [Auszug] Somatic embryos (SE) of alfalfa, celery, and cauliflower were encapsulated as single–embryo beads approximately four millimeters in diameter to produce individual somatic (artificial) seeds. The SE were mixed in sodium alginate and dropped into a solution of calcium chloride to form calcium ...
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    Nature biotechnology 4 (1986), S. 824-824 
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    Notes: [Auszug] Thirty years ago, a revolution occurred in agriculture that included some of the same companies involved in biotechnology today. With the advent of synthetic chemical pesticides, some of the most toxic chemicals known to humanity were brought to market with little debate or concern for potential ...
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    Nature biotechnology 4 (1986), S. 679-679 
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    Notes: [Auszug] When I was a boy,” an exasperated Winston Churchill once told a cravenly expedient Parliament, “there was one thing at the carnival that above all others drew my attention and my interest: The Boneless Man. Despite my pleading, my parents, probably for fear of the effect that such a ...
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    Nature biotechnology 4 (1986), S. 684-685 
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    Notes: [Auszug] CHICAGO—A central theme at this year's meeting of the Tissue Culture Association was articulated by Paul Greengard (Rockefeller University, NY): “Protein phosphorylation must have arisen very early in the evolution of cells, since it has been adapted in a myriad of ways to mediate the ...
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    Nature biotechnology 4 (1986), S. 691-691 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON—Fermentech Ltd. is seeking tie-ups with healthcare firms interested in developing products based on the hyaluronic acid (HA) the company is now producing in bulk by deep fermentation at its plant in Edinburgh, Scotland. In a paper presented to the Online-sponsored conference Biotech ...
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    Nature biotechnology 4 (1986), S. 701-705 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The biotechnology product development pipeline stretches from the lab bench to the clinics. Somewhere along that pipeline (and fairly early on), each company has to determine if, indeed, the product that shows so much promise in the laboratory will bring a profit in the market. Scale-up can answer ...
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  • 93
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Bacillus subtilis was transformed with a pUB110–derived vector carrying the Bacillus amyloliquefaciens α–amylase promoter and signal sequence to which the coding sequence for mature human interferon–α2 (IFN) was accurately fused. The level of secreted IFN was at most ...
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    Nature biotechnology 4 (1986), S. 737-737 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Cytotoxic agents. Germfree Labs, Inc. (Miami, FL) offers an educational packet, “The Safe Handling of Antineoplastics/Chemotherapeutics.” It includes original materials issued by the National Study Commission on Cytotoxic Exposure and the National Institutes of Health, and information ...
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  • 95
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    Nature biotechnology 4 (1986), S. 601-603 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—U.S. companies will require more than 1,000 new biotechnicians annually through the year 1995, according to a report from the Center for Occupational Research and Development (CORD, Waco, TX). Although most biotechnicians currently have four-year undergraduate degrees, CORD believes ...
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  • 96
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    Nature biotechnology 4 (1986), S. 606-606 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Japan Key Technology Center, Meiji Seika Kaisha (Tokyo), and Daicel Chemical Industries (Sakai-shi) have started a joint venture called M&D Research Co. to study the synthesis of active peptides for the chemical, food, and drug industries. The new company plans to research methods for ...
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    Nature biotechnology 4 (1986), S. 611-611 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] GAITHERSBURG, Md.—Enzymes and industrial processes have one basic incompatibility: most enzymes work in water while most processes in the chemical, petrochemical, and food industries (for example) simply don't. However, Alexander Klibanov (Massachusetts Institute of Technology) pointed out at ...
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  • 98
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    Nature biotechnology 4 (1986), S. 623-628 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Questions of natural relationships among microorganisms have provided many contentious punctuations in the history of microbiology. Yet, as microbial taxonomy became strictly determinative, these issues were viewed as more historical than fundamental, of interest but of little practical value. In ...
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    Nature biotechnology 4 (1986), S. 647-649 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have demonstrated expression of bacterial genes transferred into cells of loblolly pine (Pinus taeda L.) by Agrobacterium tumefaciens. Whereas previous surveys found pines resistant to Agrobacterium, we found two wild type strains that produce galls. Callus proliferated from these galls ...
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    Nature biotechnology 4 (1986), S. 660-660 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] AUGUST MEETINGS August 10–13. Congress on Research in Lymphokines and Other Cytokines. Boston, MA. Info: Congress on Research in Lymphokines and Cytokines, c/o Scherago Associates, 1515 Broadway, New York, NY 10036 Aug. 10–15. Annual Meeting of the Society for Industrial Microbiology. ...
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