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  • Rabbits
  • American Association for the Advancement of Science (AAAS)  (15)
  • Annual Reviews
  • 1980-1984  (15)
  • 1930-1934
  • 1981  (15)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (15)
  • Annual Reviews
Years
  • 1980-1984  (15)
  • 1930-1934
Year
  • 1
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    A new laser scanning system for measuring action potential propagation in the heart (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-23
    Description: A rapid laser scanning system was developed to map the spread of excitation in amphibian and mammalian hearts stained with fluorescent dye. Isochronic maps of conduction were constructed by timing the upstroke of the optical action potential; 128 sites could be scanned in 4 milliseconds. The accuracy of this technique was verified by recording simultaneously from 16 unipolar electrodes placed in different areas of the heart. Conducted action potentials in normal frog heart propagated at 0.1 meter per second. Propagation of action potentials was also monitored in ischemic cat heart, in which both driven and arrhythmic action potential upstrokes could be tracked. The results suggest that this system is capable of scanning the normal and abnormal spread of electrical activity in the heart.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dillon, S -- Morad, M -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):453-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6974891" target="_blank"〉PubMed〈/a〉
    Keywords: *Action Potentials ; Animals ; *Benzenesulfonates ; Cats ; Coronary Disease/physiopathology ; Fluorescent Dyes ; Guinea Pigs ; Heart/*physiology ; *Lasers ; Rabbits ; Rana catesbeiana ; Spectrometry, Fluorescence/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Fertilizability of ova ovulated and recovered from rabbit ovaries perfused in vitro (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: Ovaries removed from New Zealand White rabbits were perfused and exposed to gonadotropin in vitro. The ova ovulated in vitro (N = 56) were recovered and cultured and then transferred to the oviducts of six previously mated Dutch Belted hosts. Twelve of the resulting 36 offspring (33.3 percent) were white. In control matings between 12 Dutch Belted females (six randomly selected and the six hosts) and New Zealand White males, only one of 80 (1.2 percent) offspring was white. These data indicate that ova ovulated in vitro can be transferred to the oviduct of a host rabbit where they may be fertilized and after implantation may develop into viable embryos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kobayashi, Y -- Santulli, R -- Wright, K H -- Wallach, E E -- HD-05948/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1127-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268420" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chorionic Gonadotropin/*pharmacology ; Embryo Transfer ; Female ; *Fertilization in Vitro ; Ovary/drug effects/*physiology ; *Ovulation/drug effects ; Pregnancy ; Rabbits
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 3
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    The hormonal control of sexual development (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, J D -- George, F W -- Griffin, J E -- AM03892/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1278-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7010602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Mullerian Hormone ; Estradiol/metabolism/*physiology ; Female ; *Glycoproteins ; Gonadotropins/physiology ; *Growth Inhibitors ; Humans ; Male ; Morphogenesis ; Mullerian Ducts ; Ovary/embryology ; Rabbits ; Receptors, Androgen/metabolism ; *Sex Differentiation ; Testicular Hormones/*physiology ; Testis/embryology/secretion ; Testosterone/metabolism/*physiology ; Time Factors ; Urogenital System/embryology ; Wolffian Ducts
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Purified reduced nicotinamide adenine dinucleotide: responses to lactate dehydrogenase isozymes from three cell sources (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: Lactate dehydrogenase (LDH, E.C. 1.1.1.27) isozymes from three single-cell sources reacted differently with reduced nicotinamide adenine dinucleotide (NADH) purified to published chromatographic and spectrophotometric specifications and free of inhibitors of LDH, when compared with a commercial preparation of NADH. The activity of LDH-1, purified from rabbit erythrocytes, increased the most with inhibitor-free NADH; the next most stimulated were the LDH isozymes from a control hepatocyte line; but hardly responsive at all were the same isozymes from chemically transformed cells. Thus isozyme composition alone did not account for the range of responses to purified NADH. The commercial preparation of NADH used in these studies contains the Strandjord-Clayson inhibitors, the most potent group identified in NADH preparations relative to LDH activity. The results suggest that specific molecular differences in individual isozymes contribute to the differential response to the Strandjord-Clayson inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaplan, A E -- Weiss, E R -- Byrne, S T -- El-Torkey, N M -- Margolis, S A -- New York, N.Y. -- Science. 1981 May 1;212(4494):553-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209551" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/enzymology ; Isoenzymes ; L-Lactate Dehydrogenase/antagonists & inhibitors/*metabolism ; Liver Neoplasms, Experimental/enzymology ; NAD/analysis/*metabolism ; Rabbits ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Specific and sensitive radioimmunoassay for 3-methoxy-4-hydroxyphenylethyleneglycol (MOPEG) (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-06
    Description: Antibodies that specifically bind the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MOPEG) were produced in rabbits after injection of a derivative of MOPEG conjugated with bovine thyroglobulin. A sensitive radioimmunoassay was devised with this antiserum, in which as little as 0.5 nanogram of MOPEG can be accurately measured with a final antibody dilution of 1:180. The antibody appears to be specific for MOPEG, since tritiated MOPEG was not displaced from the antibodies by norepinephrine, epinephrine, dopamine, serotonin, or their major metabolites including MOPEG-sulfate (333 nanograms each).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keeton, T K -- Krutzsch, H -- Lovenberg, W -- New York, N.Y. -- Science. 1981 Feb 6;211(4482):586-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455697" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Brain/*metabolism ; Brain Mapping ; Glycols/*analysis ; Methoxyhydroxyphenylglycol/*analysis/metabolism ; Rabbits ; *Radioimmunoassay/methods ; Rats ; Thyroglobulin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 6
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    Serum albumin beads: an injectable, biodegradable system for the sustained release of drugs (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: Biologically active compounds were entrapped in cross-linked serum albumin microbeads. Injection of these drug-impregnated beads into rabbits produced no adverse immunological reactions. Sustained release (20 days) of progesterone was demonstrated in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, T K -- Sokoloski, T D -- Royer, G P -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):233-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6787705" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Delayed-Action Preparations ; Glutaral ; Injections, Intramuscular ; Injections, Subcutaneous ; Kinetics ; Male ; Microscopy, Electron, Scanning ; Norgestrel/administration & dosage ; Progesterone/*administration & dosage/blood ; Rabbits ; Serum Albumin, Bovine/*administration & dosage
    Print ISSN: 0036-8075
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  • 7
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    Assessment of pharmacological treatment of myocardial infarction by phosphorus-31 NMR with surface coils (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-09
    Description: Phosphorus-31 nuclear magnetic resonance (NMR) measurements with small surface coils have been used to observe phosphorus metabolism of perfused hearts within localized regions. The method allows for direct, noninvasive, sequential assessment of the altered regional metabolism resulting from myocardial infarction and its response to drug treatment, which cannot be observed by conventional techniques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nunnally, R L -- Bottomley, P A -- GM 17172/GM/NIGMS NIH HHS/ -- HL 17655-06/HL/NHLBI NIH HHS/ -- HL 22080/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 9;211(4478):177-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chlorpromazine/therapeutic use ; Coronary Circulation/drug effects ; Disease Models, Animal ; Magnetic Resonance Spectroscopy/*methods ; Myocardial Infarction/*diagnosis/drug therapy/metabolism ; Phosphorus/*metabolism ; Phosphorus Isotopes ; Rabbits ; Verapamil/therapeutic use
    Print ISSN: 0036-8075
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  • 8
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    Hyperkeratosis induced by sunlight degradation products of the major polybrominated biphenyl in Firemaster (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-21
    Description: Sunlight photodegradation of 2,2', 4,4', 5,5' -hexabromobiphenyl, the major component of Firemaster, gave a mixture that produces severe hyperkeratosis of the rabbit ear. This component in its pure state does not cause hyperkeratosis. One or more of the four major photolysis products must be responsible for this activity. A similar photodegradation pattern was observed for 2,2', 3,4,4', 5,5' -heptabromobiphenyl, the second largest component of Firemaster.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patterson, D G -- Hill, R H -- Needham, L L -- Orti, D L -- Kimbrough, R D -- Liddle, J A -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):901-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6266016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biphenyl Compounds/radiation effects ; Chemical Industry ; Disease Models, Animal ; Environmental Exposure ; Keratosis/*chemically induced ; Michigan ; Photochemistry ; *Polybrominated Biphenyls/radiation effects ; Rabbits ; Sunlight
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 9
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    Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Radioactive nitrogen-13 from nitrite (NO2-) or nitrate (NO3-) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered. Nitrogen-13 from both anions was distributed uniformly between plasma and blood cells. We found rapid in vivo oxidation of NO2- to NO3- at concentrations of 2 to 3 nanomoles per liter in blood. Over 50 percent oxidation within 10 minutes accounted for the similar nitrogen-13 distributions from both parent ions. The oxidation rates were animal species-dependent. No reduction of 13NO3- to 13NO2- was observed. A mechanistic hypothesis invoking oxidation of 13NO2- by a catalase-hydrogen peroxide complex accounts for the results. These results imply a concentration dependence for the in vivo fate of NO2- or nitrogen dioxide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parks, N J -- Krohn, K J -- Mathis, C A -- Chasko, J H -- Geiger, K R -- Gregor, M E -- Peek, N F -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):58-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209517" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatography, High Pressure Liquid ; Injections, Intravenous ; Mice ; Mice, Inbred BALB C ; Nitrates/administration & dosage/*metabolism ; Nitrites/administration & dosage/*metabolism ; Nitrogen Isotopes ; Oxidation-Reduction ; Rabbits ; Species Specificity ; Tissue Distribution ; Trachea
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 10
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    Plasmid DNA in Treponema pallidum (Nichols): potential for antibiotic resistance by syphilis bacteria (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: A plasmid DNA structure (approximate molecular weight = 7.5 X 10(6)) was identified in the human pathogen Treponema pallidum (Nichols). The inability to isolate this plasmid from rabbit host tissue and the total lack of DNA homology of the plasmid with rabbit DNA has confirmed its Treponema pallidum origin. The observation documents a newly recognized and potentially significant genetic capability for Treponema pallidum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norgard, M V -- Miller, J N -- NIAID-12601/AI/NIAID NIH HHS/ -- NIAID-16692/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):553-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; DNA Restriction Enzymes ; DNA, Bacterial/*genetics ; DNA, Recombinant/metabolism ; Drug Resistance, Microbial ; Microscopy, Electron ; Molecular Weight ; Nucleic Acid Hybridization ; *Plasmids ; Protein Biosynthesis ; Rabbits ; Treponema pallidum/*genetics
    Print ISSN: 0036-8075
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  • 11
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    Species restriction of a monoclonal antibody reacting with residues 130 to 137 in encephalitogenic myelin basic protein (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: A monoclonal antibody (immunoglobulin G1) has been produced that reacts against myelin basic protein present in or extracted from the brains of many mammals-with certain important exceptions. Because of known species differences in amino acid sequences of basic protein and of certain peptide fragments, the binding site for this particular antibody appeared likely to include residues 130 to 137. Confirmation of this hypothesis was obtained by amino acid composition of the major immunoreactive peptides produced by thermolysin digestion of human basic protein and isolated by high-performance liquid chromatography.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sires, L R -- Hruby, S -- Alvord, E C Jr -- Hellstrom, I -- Hellstrom, K E -- Kies, M W -- Martemspm, R -- Deibler, G E -- Beckman, E D -- Casnellie, J E -- CA-19148/CA/NCI NIH HHS/ -- CA-25558/CA/NCI NIH HHS/ -- CA-26584/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):87-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169147" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Monoclonal ; Cattle ; Chickens ; Epitopes ; Guinea Pigs ; Humans ; Macaca ; Myelin Basic Protein/*immunology ; Peptide Fragments/immunology ; Rabbits ; Rats ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Molecular and cellular mechanisms of leukocyte chemotaxis (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-21
    Description: The application of modern scientific methods to the study of leukocyte function has begun to reveal the molecular and cytostructural bases of the chemotactic responses of these cells. Leukocyte chemotaxis is initiated by the binding of chemoattractants to distinct plasma membrane receptors; this finding alters transmembrane potential and activates ionic fluxes. The subsequent sequence of metabolic processes leads to a rearrangement of cytoskeletal elements that is manifested by orientation and migration of the cells toward the source of the chemotactic gradient.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyderman, R -- Goetzl, E J -- HL 19777/HL/NHLBI NIH HHS/ -- R01 DE 03738/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):830-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6266014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/physiology ; Chemotactic Factors/*physiology ; *Chemotaxis, Leukocyte ; Cytoskeleton/*physiology ; Electric Conductivity ; Guinea Pigs ; Humans ; Lymphokines/physiology ; Microscopy, Electron, Scanning ; Microtubules/*physiology ; Neutrophils/physiology ; Nucleotides, Cyclic/physiology ; Rabbits ; Receptors, Cell Surface/*physiology ; Receptors, Formyl Peptide
    Print ISSN: 0036-8075
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  • 13
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    A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-27
    Description: Neurogenic factors released by antidromic nerve stimulation are thought to be in part responsible for the vasodilation and breakdown of the blood-aqueous barrier that follows trauma to the eye. Substance P is one candidate for the mediation of the inflammatory response since it is thought to be a neurotransmitter in sensory afferents and since exogenous substance P is capable of eliciting a response characteristic of inflammation. In rabbits, intravitreal or topical application onto the eye of a specific substance P antagonist, [d-Pro2, D-Trp7,9]SP, inhibited not only the irritant effects of exogenous substance P but also the inflammatory response to a standardized trauma (infrared irradiation of the iris). These observations suggest that substance P, or a related peptide, is a neurogenic mediator of the inflammatory response in the eye.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holmdahl, G -- Hakanson, R -- Leander, S -- Rosell, S -- Folkers, K -- Sundler, F -- New York, N.Y. -- Science. 1981 Nov 27;214(4524):1029-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6171036" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Eye Diseases/*drug therapy ; Inflammation/*drug therapy ; Infrared Rays ; Pupil/drug effects/radiation effects ; Rabbits ; Structure-Activity Relationship ; Substance P/*analogs & derivatives/*antagonists & inhibitors/therapeutic use
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  • 14
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    Globin gene transferred (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1488.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280666" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *DNA, Recombinant ; Female ; Globins/*genetics ; Male ; Mice ; Plasmids ; Rabbits
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  • 15
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    Angiogenesis inhibitors link many diseases (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1374-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233226" target="_blank"〉PubMed〈/a〉
    Keywords: Angiogenesis Inducing Agents/*antagonists & inhibitors ; Angiogenesis Inhibitors ; Animals ; Cattle ; Cornea/blood supply/drug effects ; *Growth Inhibitors ; Humans ; Mice ; Neoplasms/analysis/blood supply/*drug therapy ; Neoplasms, Experimental/*blood supply/*drug therapy ; Proteins/pharmacology/*therapeutic use ; Rabbits ; Retina/analysis
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