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  • History  (875)
  • R5-920  (734)
  • Chemistry
  • Humans
  • 2020-2024  (1,619)
  • 2021  (1,619)
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  • 1
    Publication Date: 2024-04-08
    Description: The „Flecken Adelebsen“ at the edge of the „Solling“ in southern Lower-Saxony looks back to 300 years of jewish history. In 19th century it was named “Little Jerusalem” because of the high number of jewish habitants. Today only the jewish graveyard has outlived. The aim of this documentation is to tap this “House of Living” as a new historical resource and do a part of an outstanding and necessary mourning work.
    Keywords: Lower Saxony ; Bremen ; History ; History of Jewry beyond Israel ; bic Book Industry Communication::H Humanities::HR Religion & beliefs ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRJ Judaism ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRJ Judaism
    Language: German
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 4
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    Duke University Press
    Publication Date: 2024-04-02
    Description: In 'An Aqueous Territory' Ernesto Bassi traces the configuration of a geographic space he calls the transimperial Greater Caribbean between 1760 and 1860. Focusing on the Caribbean coast of New Granada (present-day Colombia), Bassi shows that the region's residents did not live their lives bounded by geopolitical borders. Rather, the cross-border activities of sailors, traders, revolutionaries, indigenous peoples, and others reflected their perceptions of the Caribbean as a transimperial space where trade, information, and people circulated, both conforming to and in defiance of imperial regulations. Bassi demonstrates that the islands, continental coasts, and open waters of the transimperial Greater Caribbean constituted a space that was simultaneously Spanish, British, French, Dutch, Danish, Anglo-American, African, and indigenous.
    Keywords: History ; Colombia ; Haiti ; Jamaica ; Riohacha ; Santa Marta ; Spain ; United States ; Wayuu people ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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  • 5
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    Böhlau
    Publication Date: 2024-04-04
    Description: The attraction of crises keeps going an entire sector of the media industry. Authors, painters, photographers and directors tell fascinating stories about the decline of empires and democracies as much as earthquakes and infectious diseases. Hereby, catastrophe and collapse evolve as a complex construct of experience, interpretation and emotion. The resulting narrative combines analyses of facts about the collapse with a retrospect evaluation, update and confirmation of these facts in the cultural memory of a given society. The random occurrence becomes a memorable event. The contributors of this volume have taken a narratological approach in examining collapse, disaster, catastrophe and how these in turn manifest themselves across different types of media.
    Keywords: History ; Social History ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English
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  • 6
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    Duke University Press
    Publication Date: 2022-05-02
    Description: In CHINESE SURPLUS Ari Heinrich dissects the figure of the medically or artistically commodified body in Chinese culture and popular science. Providing a history of how bodies have been thought and seen to mirror the nation, Heinrich charts the trajectory from an imperial idea of the body as a machine with interchangeable parts to current representations in which the parts are worth more than the whole and may be harvested at will--what he calls a diasporic form of the body. In seeing the body this way Heinrich makes clear his case for a new method he calls biopolitical aesthetics, one that uses the tools of literary and visual culture analysis to restore agency to aesthetics in the production of meaning in life during contemporary biopolitical times.
    Keywords: History ; Aesthetics ; China ; Hong Kong
    Language: English
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  • 7
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 8
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    University of Michigan Press | University of Michigan Press
    Publication Date: 2024-04-02
    Description: "Printing and Prophecy: Prognostication and Media Change 1450-1550 examines prognostic traditions and late medieval prophetic texts in the first century of printing and their effect on the new medium of print. The many prophetic and prognostic works that followed Europe's earliest known printed book—not the Gutenberg Bible, but the Sibyl's Prophecy, printed by Gutenberg two years earlier and known today only from a single page—over the next century were perennial best sellers for many printers, and they provide the modern observer with a unique way to study the history and inner workings of the print medium. The very popularity of these works, often published as affordable booklets, raised fears of social unrest. Printers therefore had to meet customer demand while at the same time channeling readers' reactions along approved paths. Authors were packaged—and packaged themselves—in word and image to respond to the tension, while leading figures of early modern culture such as Paracelsus, Martin Luther, and Sebastian Brant used printed prophecies for their own purposes in a rapidly changing society. Based on a wide reading of many sources, Printing and Prophecy contributes to the study of early modern literature, including how print changed the relationship among authors, readers, and texts. The prophetic and astrological texts the book examines document changes in early modern society that are particularly relevant to German studies and are key texts for understanding the development of science, religion, and popular culture in the early modern period. By combining the methods of cultural studies and book history, this volume brings a new perspective to the study of Gutenberg and later printers."
    Keywords: History ; Astrology ; Latin ; Lichtenberger ; Practica (astrology) ; Prophecy ; Woodcut ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 9
    Publication Date: 2023-12-21
    Description: Um livro valioso, que analisa com clareza o papel fundamental dos recursos humanos para a saúde e o desenvolvimento, bem como o contexto e o impacto da reforma sanitária e a relação entre as iniciativas internacionais, nacionais e locais em prol da mudança dos serviços de saúde. Além de examinar os antecedentes e os principais atores da área de recursos humanos e explicar com detalhes as negociações que visavam transformar em prioridade nacional a formação de recursos humanos e a distribuição dos trabalhadores de saúde no território, Recursos Críticos está apoiado em uma sólida pesquisa bibliográfica, testemunhos fascinantes e análise original, que fazem da obra uma contribuição significativa no campo da memória da saúde pública e uma ferramenta indicativa de perspectivas de futuro para trabalhadores na área da saúde. É uma pesquisa histórica de grande qualidade, voltada para a análise da cooperação Opas-Brasil, e um incentivo à realização de novos estudos sobre as interfaces entre a atuação de agências internacionais e os interesses nacionais, partindo do conceito de arenas ou espaços de negociação.
    Keywords: R5-920 ; Brasil ; Recursos humanos em saúde ; Planos e programas de saúde ; Cooperação técnica ; Organização Pan-Americana da Saúde ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 10
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-04-04
    Description: Gesellschaften mit starker Einwanderung kennzeichnen vielfältige Formen von Identitätsbildung und das Ringen um politische und zivilgesellschaftliche Partizipation. Dies gilt in besonderer Weise für Luxemburg im 19. und 20. Jahrhundert. Hier entstand in einem Kleinstaat eine der jüngeren Nationen Europas und zugleich eine besonders offene, plurikulturelle Einwanderungsgesellschaft. Ziel dieses Bandes ist es, die Entstehung dieser Mehr-Kulturen-Gesellschaft im europäischen Zusammenhang zu verstehen. Die einzelnen Beiträge analysieren mit Hilfe unterschiedlicher sozial- und kulturwissenschaftlicher Annäherungen exemplarische Konfliktlinien der Identitätsbildung und des Kampfes um Partizipation.
    Keywords: European history ; Biography: general ; Language teaching and learning ; History ; Social and cultural history ; General and world history ; Literature: history and criticism ; Literary studies: ancient, classical and medieval ; Literary theory ; Philosophy ; Politics and government ; Civics and citizenship ; Political science and theory ; Political control and freedoms ; Anthropology ; Social and cultural anthropology ; Ethnic studies ; Gender studies: women and girls ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: German
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  • 11
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 12
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders;celiac disease;gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 14
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 15
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: For the first time, this book examines the comparative impact of the Obama administration on the NATO and defense policies of European allies. Germany, Poland and Turkey serve as case studies to evaluate American policies vis-à-vis NATO Europe. All three are representative for the Alliance in various ways. Thus, the results of this book offer an outlook for NATO Europe and the Alliance as a whole. Despite the fact that all three countries are highly dependent on American security guarantees in theory and practice, the results of this study reveal different national responses. Indeed, the book demonstrates multi-, bi-, and unilateralization attempts in reaction to US engagement in and vis-à-vis NATO Europe. Hence, a better understanding of current developments within the Alliance as well as the basis for the future debate about the transatlantic organisation are provided. Aylin Matlé works for the Konrad-Adenauer-Stiftung e.V.; most recently, she worked for the foundation's Israel office in Jerusalem. Previously, Aylin Matlé was a research associate at the chair of international relations and European politics at the Martin-Luther-Universität Halle-Wittenberg.
    Keywords: History ; Military ; Political Science ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 16
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 17
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    Brill | Brill
    Publication Date: 2024-04-01
    Description: In The Jesuit Order as a Synagogue of Jews the author explains how Christians with Jewish ancestry went within less than forty years from having a leading role in the foundation and development of the Society of Jesus to being prohibited from membership in it. Readership: All those interested in converso and Jesuit history, the history of Catholicism, the history of late medieval and early modern Iberia and Italy, as well as Spanish literature historians, historians of law, and theologians.
    Keywords: History ; Jewish History & Culture ; Converso ; Ignatius of Loyola ; Rome ; Society of Jesus ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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  • 18
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    Historic England | Historic England
    Publication Date: 2024-03-23
    Description: St Peter's, Barton-upon-Humber, is a redundant medieval church in the care of English Heritage. As a result of a major program of research carried out between 1978 and 2007, it is now the most intensively studied parish church in the UK. Excavations between 1978 and 1984 investigated most of the interior of the building, as well as a swathe of churchyard around its exterior. At the same time, a stone-by-stone record and detailed archaeological study of the fabric and furnishings of the church was undertaken, continuing down to 2007. The twin aims of the project were to understand the architectural history and setting of this complex, multi-period building (Volume 1, Parts 1 and 2) and to recover a substantial sample of the population for palaeopathological study (Volume 2). An extensive program of historical and topographical research also took place in order to set the archaeological evidence firmly in context.
    Keywords: Architecture ; History ; History ; Europe ; Medieval ; History ; Europe ; Great Britain ; thema EDItEUR::A The Arts::AM Architecture::AMX History of architecture ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 19
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    Frontiers Media SA
    Publication Date: 2022-01-31
    Description: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Keywords: RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
    Language: English
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  • 20
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
    Language: English
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    Academic Studies Press | Academic Studies Press
    Publication Date: 2024-03-27
    Description: Filled with new elements that challenge common scholarly theses, this book acquaints the reader with the “Jewish problem” of sociology and provides what this academic discipline urgently needs: a one-volume history of the Sociology of the Holocaust. The story of why and how sociologists as well as the schools of sociological thought came to confront the Holocaust has never been entirely told. The volume offers original insights on the nature of American sociology with implications for the post-Holocaust sociology development.
    Keywords: Fiction ; Action & Adventure ; History ; Holocaust ; thema EDItEUR::F Fiction and Related items::FJ Adventure / action fiction ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTZ Genocide and ethnic cleansing::NHTZ1 The Holocaust ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR7 Second World War ; thema EDItEUR::1 Place qualifiers::1D Europe ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBL c 1940 to c 1949
    Language: English
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    transcript Verlag
    Publication Date: 2024-03-29
    Description: Szenen einer missvergnügten Ehe - dieses bürgerliche Trauerspiel wird derzeit auf den politischen Bühnen westlicher Demokratien gegeben. Es führt vor, wie weit sich Regierende und Regierte auseinander gelebt haben. Von heute auf morgen passiert so etwas nicht. Der Band lässt die wechselvolle Geschichte des Regierens Revue passieren und zeigt, wie angespannt das Verhältnis seit jeher gewesen ist. Dass Kanzler Könige und Bürger Bauern abgelöst haben, hat daran nichts geändert. Andererseits hält diese Mesalliance erstaunlich viel aus - selbst nach blutigen Konflikten arrangiert man sich wieder und findet ein neues Gleichgewicht der Frustration. Die Hoffnung, es gehe trotz allem stetig aufwärts, muss derzeit wieder einmal begraben werden.
    Keywords: Political Science ; Governance ; Resistance ; Souvereignity ; Representation ; Repression ; Loyalty ; Disenchantment with Politics ; Neoliberalism ; Politics ; Political Theory ; Democracy ; History ; Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: German
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  • 24
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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  • 25
    Publication Date: 2024-04-02
    Description: This volume provides an ambitious synopsis of the complex, colourful world of textiles in ancient Mediterranean iconography. A wealth of information on ancient textiles is available from depictions such as sculpture, vase painting, figurines, reliefs and mosaics. Commonly represented in clothing, textiles are also present in furnishings and through the processes of textile production. The challenge for anyone analysing ancient iconography is determining how we interpret what we see. As preserved textiles rarely survive in comparable forms, we must consider the extent to which representations of textiles reflect reality, and critically evaluate the sources. Images are not simple replicas or photographs of reality. Instead, iconography draws on select elements from the surrounding world that were recognisable to the ancient audience, and reveal the perceptions, ideologies, and ideas of the society in which they were produced. Through examining the durable evidence, this anthology reveals the ephemeral world of textiles and their integral role in the daily life, cult and economy of the ancient Mediterranean.
    Keywords: History ; Ancient ; Rome ; History ; Ancient ; Design ; Textile & Costume ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::A The Arts::AK Design, Industrial and commercial arts, illustration::AKT Fashion and textile design
    Language: English
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  • 26
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
    Language: English
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  • 27
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    Franz Steiner Verlag
    Publication Date: 2024-04-04
    Description: Wie erklärt sich Wirtschaftserfolg? Dieser Frage geht Beat Fumasoli mit Blick auf die gewerbliche Exportwirtschaft von oberdeutschen Städten im Spätmittelalter nach. Der oberdeutsche Wirtschaftsraum gewann besonders ab dem 14. Jahrhundert stark an Bedeutung – seine zentrale Lage in der Mitte Europas ermöglichte einen weit ausgreifenden Exporthandel in alle Himmelsrichtungen. Mit Augsburg, Basel, Freiburg im Üechtland, Nördlingen, Nürnberg, Passau, Ravensburg, Regensburg, Schwäbisch Gmünd, Speyer, St. Gallen und Wangen im Allgäu betrachtet Fumasoli gut ein Fünftel der oberdeutschen Städte mit Exportgewerbe und unterzieht sie einem systematischen Vergleich. Dieser erstreckt sich auf alle potenziell relevanten Einflussfaktoren des exportgewerblichen Wirtschaftserfolgs: von den Rahmenbedingungen für Produktion und Handel bis hin zu den Organisations- und Absatzstrategien der Wirtschaftsakteure und ihrer Kooperation in einem hochgradig arbeitsteiligen Gesamtsystem.
    Keywords: History ; Mittelalter ; Middle Ages ; Medieval History ; Wirtschafts- und Sozialgeschichte ; Stadtgeschichte ; Urban History ; Innovation ; Handelsgeschichte ; History ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: German
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    De Gruyter
    Publication Date: 2024-03-29
    Description: Anhand neuer Quellen werden die Berliner 'jüdischen Salons' um 1800 als ebenso lebendiges wie fragiles kommunikatives Netz präsentiert. Der Querschnitt durch die Salongesellschaft des Beispieljahrs 1794/95 beleuchtet eine Geselligkeitskultur, in der verschiedene Orte zu Salons wurden. Längsschnitte durch jahrzehntelang geführte Korrespondenzen erlauben die Frage nach Wechselwirkungen zwischen Salons und zeitgenössischen Emanzipationsdiskursen.
    Keywords: Jewish Studies ; Europe ; Germany ; HIS022000 ; History ; Jewish ; LIT004210 ; SOC049000 ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSR Social groups: religious groups and communities ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PG Relating to religious groups::5PGJ Relating to Jewish people and groups
    Language: English
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  • 29
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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    Central European University Press
    Publication Date: 2024-04-04
    Description: This social, cultural, and political history of Slavic Muslim women of the Yugoslav region in the first decades of the post-Ottoman era is the first to provide a comprehensive overview of the issues confronting these women. It is based on a study of voluntary associations (philanthropic, cultural, Islamic-traditionalist, and feminist) of the period. It is broadly held that Muslim women were silent and relegated to a purely private space until 1945, when the communist state “unveiled” and “liberated” them from the top down.  After systematic archival research in Bosnia, Croatia, Serbia, and Austria, Fabio Giomi challenges this view by showing:  How different sectors of the Yugoslav elite through association publications, imagined the role of Muslim women in post-Ottoman times, and how Muslim women took part in the construction or the contestation of these narratives.  How associa­tions employed different means in order to forge a generation of “New Muslim Women” able to cope with the post-Ottoman political and social circumstances.  And how Muslim women used the tools provided by the associations in order to pursue their own projects, aims and agendas.  The insights are relevant for today’s challenges facing Muslim women in Europe. The text is illustrated with exceptional photographs.
    Keywords: History ; Women ; History ; Europe ; Eastern ; Social Science ; Gender Studies ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups
    Language: English
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    Vandenhoeck & Ruprecht
    Publication Date: 2024-04-02
    Description: This volume presents the contributions to a symposium held on May 9th, 2009 at the Humanities Center at Harvard University that focused on the question of how peace and interstate stability were established and maintained in archaic and classical Greece. In this context, different perspectives and approaches, ranging from pragmatic political goals and the definition and interpretation of key terms such as eirene to the underlying norms and their relevance for the realpolitik, were discussed. The articles in this volume shed new light on the various political instruments that the Greeks developed and employed to avoid war and to keep and organize peace. They focus on the analysis of commonly accepted terms that provided the basis for a settlement between conflicting parties and the analysis of various political strategies, including one-time arrangements to limit military conflicts, diplomatic efforts, legally binding agreements and more comprehensive concepts of interstate stability.
    Keywords: History ; Ancient ; General ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history
    Language: English
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  • 32
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    University of California Press | University of California Press
    Publication Date: 2024-04-01
    Description: Ginseng and Borderland explores the territorial boundaries and political relations between Qing China and Chosŏn Korea during the period from the early seventeenth to the late nineteenth centuries. By examining a unique body of materials written in Chinese, Manchu, and Korean, and building on recent studies in New Qing History, Seonmin Kim adds new perspectives to current understandings of the remarkable transformation of the Manchu Qing dynasty (1636–1912) from a tribal state to a universal empire. This book discusses early Manchu history and explores the Qing Empire’s policy of controlling Manchuria and Chosŏn Korea. Kim also contributes to the Korean history of the Chosŏn dynasty (1392–1910) by challenging conventional accounts that embrace a China-centered interpretation of the tributary relationship between the two polities, stressing instead the agency of Chosŏn Korea in the formation of the Qing Empire. This study demonstrates how Koreans interpreted and employed this relationship in order to preserve the boundary—and peace—with the suzerain power. By focusing on the historical significance of the China-Korea boundary, this book defines the nature of the Qing Empire through the dynamics of contacts and conflicts under both the cultural and material frameworks of its tributary relationship with Chosŏn Korea.
    Keywords: History ; General ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Academic Studies Press | Academic Studies Press
    Publication Date: 2024-04-04
    Description: This groundbreaking book focuses on Alfred Dreyfus the man, with emphasis placed on his own writings, including his recently published prison workbooks and his letters to his wife Lucie. Through close reading of these documents, a much more sensitive, intellectual, and Jewish man is revealed than was previously suspected. He and Lucie, through their family connections and mutual loyalty, were interested in and supported the artistic, scientific, philosophical and historical movements that formed their Parisian milieu. But as an Alsatian Jew, Alfred was also critical of many aspects of technological and ideological developments, making his mentality one of skepticism as well as idealism.
    Keywords: History ; Jewish ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English
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    Historic England | Historic England
    Publication Date: 2024-04-04
    Description: This volume offers a new and up-to-date synthesis of Lincoln's long history as a major city and regional capital, from prehistory to 1945. The 'City by the Pool' was a major religious centre long before the Roman invasion and from bronze-age shamans to early Baptists people have always been attracted here for spiritual as well as mundane purposes. The authors argue for the presence of a major ritual causeway of the late Bronze and Iron Age and outline the extent to which ritual monuments also contributed to the character of Roman Lincoln. This book is based on more than a hundred publicly-funded excavations and building surveys undertaken between 1945 and 2000. It surveys all aspects of city life, from housing and fortifications to the water supply and rubbish disposal. It includes a CD Rom with a Geographic Information System (GIS) and a relational data-base known as LARA (the Lincoln Archaeological Research Assessment).
    Keywords: Social Science ; Archaeology ; History ; Europe ; Great Britain ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Publicacions i Edicions de la Universitat de Barcelona
    Publication Date: 2023-12-21
    Description: La relación médico-paciente está sometida a varias presiones. La financiación de la asistencia sanitaria puede determinar tanto la percepción colectiva del acceso a los recursos sociales (prestaciones económicas, centros de atención especializada, ayudas a domicilio, entre otros) como la prescripción de medicamentos y de pruebas complementarias. Además de las prioridades del financiador o de los beneficiarios de los resultados económicos, las campañas publicitarias influyen también en el criterio del paciente, al que la industria farmacéutica halaga convenciéndolo de que posee conocimientos de medicina y de que es un consumidor con el poder de escoger, cuando en realidad decide porque tiene los medios económicos para pagar su elección. En este libro se analizan las razones que empujan a los profesionales de la sanidad hacia una parcialidad interesada, así como las consecuencias éticas que ello tiene sobre el individuo y sobre la eficiencia del sistema sanitario.
    Keywords: R5-920 ; RA1-1270 ; BJ1-1725 ; Relacions metge-pacient ; Medicina ; Dret ; bic Book Industry Communication::M Medicine
    Language: Spanish
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  • 36
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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    Bloomsbury Academic
    Publication Date: 2023-11-16
    Description: Women’s Activism and "Second Wave" Feminism situates late 20th century feminisms within a global framework of women’s activism. Its chapters, written by leading international scholars, demonstrate how issues of heterogeneity, transnationalism, and intersectionality have transformed understandings of historical feminism. It is no longer possible to imagine that feminism has ever fostered an unproblematic sisterhood among women blind to race, ethnicity, class, sexuality, nationality and citizenship status. The chapters in this collection modify the "wave" metaphor in some cases and in others re-periodize it. By studying individual movements, they collectively address several themes that advance our understandings of the history of feminism, such as the rejection of "hegemonic" feminism by marginalized feminist groups, transnational linkages among women’s organizations, transnational flows of ideas and transnational migration.
    Keywords: History ; History of Feminism ; Women's activism ; Transnationalism ; Intersectionality ; Hisotrical Feminism ; Feminist Waves ; Gender Studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFK Feminism & feminist theory
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
    Language: English
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
    Language: English
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  • 40
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    Amsterdam University Press | Pallas Publications
    Publication Date: 2024-04-01
    Description: Women and Power at the French Court, 1483—1563 explores the ways in which a range of women “ as consorts, regents, mistresses, factional power players, attendants at court, or as objects of courtly patronage “ wielded power in order to advance individual, familial, and factional agendas at the early sixteenth-century French court. Spring-boarding from the burgeoning scholarship of gender, the political, and power in early modern Europe, the collection provides a perspective from the French court, from the reigns of Charles VIII to Henri II, a time when the French court was a renowned center of culture and at which women played important roles. Crossdisciplinary in its perspectives, these essays by historians, art and literary scholars investigate the dynamic operations of gendered power in political acts, recognized status as queens and regents, ritualized behaviors such as gift-giving, educational coteries, and through social networking, literary and artistic patronage, female authorship, and epistolary strategies.
    Keywords: History ; women ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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  • 41
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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  • 42
    Publication Date: 2023-12-21
    Description: Reúne textos de especialistas das áreas de Saúde e de Educação com longa, competente e comprometida atuação na luta por mudanças sociais, preocupados com um (con)viver humano mais solidário. A obra mostra ser possível a constituição de serviços de saúde com profissionais sensíveis e preparados para atuar em tempos de novas exigências técnicas e de capacitação profissional. Por instigar a (re)pensar o aperfeiçoamento técnico e ético do trabalho, com idéias e propostas originais e atuais, trata-se, certamente, de contribuição de relevância para aqueles que, direta ou indiretamente, encontram-se engajados na causa do Sistema Único de Saúde.
    Keywords: R5-920 ; Pessoal técnico de saúde-educação ; Ocupação em saúde ; educação profissional ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 43
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    University of London Press | University of London Press
    Publication Date: 2024-04-01
    Description: Creative Spaces: Urban Culture and Marginality is an interdisciplinary exploration of the different ways in which marginal urban spaces have become privileged locations for creativity in Latin America. The essays within the collection reassess dominant theoretical notions of ‘marginality’ in the region and argue that, in contemporary society, it invariably allows for (if not leads to) the production of the new. While Latin American cities have, since their foundation, always included marginal spaces (due, for example, to the segregation of indigenous groups), the massive expansion of informal housing constructed on occupied land in the second half of the twentieth century have brought them into the collective imaginary like never before. Originally viewed as spaces of deprivation, violence, and dangerous alterity, the urban margins were later romanticized as spaces of opportunity and popular empowerment. Instead, this volume analyses the production of new art forms, political organizations and subjectivities emerging from the urban margins in Latin America, neither condemning nor idealizing the effects they produce. To account for the complex nature of contemporary urban marginality, the volume draws on research from a wide spectrum of disciplines, ranging from cultural and urban studies to architecture and sociology. Thus the collection analyzes how these different conceptions of marginal spaces work together and contribute to the imagined and material reality of the wider city.
    Keywords: marginality ; liminality ; urbanity ; diaspora ; migration ; population ; History ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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  • 44
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
    Language: English
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  • 45
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    Vandenhoeck & Ruprecht
    Publication Date: 2024-04-02
    Description: Ancient Rome has always been considered a compendium of City and World. In the Renaissance, an era of epistemic fractures, when the clash between the 'new science' (Copernicus, Galileo, Vesalius, Bacon, etcetera) and the authority of ancient texts produced the very notion of modernity, the extended and expanding geography of ancient Rome becomes, for Shakespeare and the Elizabethans, a privileged arena in which to question the nature of bodies and the place they hold in a changing order of the universe. Drawing on the rich scenario provided by Shakespeare's Rome, and adopting an interdisciplinary perspective, the authors of this volume address the way in which the different bodies of the earthly and heavenly spheres are re-mapped in Shakespeare's time and in early modern European culture. More precisely, they investigate the way bodies are fashioned to suit or deconstruct a culturally articulated system of analogies between earth and heaven, microcosm and macrocosm. As a whole, this collection brings to the fore a wide range of issues connected to the Renaissance re-mapping of the world and the human. It should interest not only Shakespeare scholars but all those working on the interaction between sciences and humanities.
    Keywords: History ; Europe ; Renaissance ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 46
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
    Language: English
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  • 47
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    Ledizioni
    Publication Date: 2023-12-21
    Description: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Keywords: R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
    Language: English
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    SciELO Books - Editora FIOCRUZ
    Publication Date: 2023-12-21
    Description: Leitores interessados no desenvolvimento teórico da bioética e, ao mesmo tempo, em sua aplicação na solução de conflitos morais certamente encontrarão neste livro materiais de grande valor. Cada capítulo coloca a bioética em um contexto diferente: na clínica, na genômica e na biossegurança. No primeiro ensaio, discutem-se as possibilidades dessa ‘caixa de ferramentas’ chamada bioética para compreender e tentar resolver conflitos de interesses e valores no âmbito das relações entre profissionais e usuários dos serviços de saúde. No segundo, o autor aplica as ferramentas da bioética ao caso dos conflitos morais que envolvem a genômica, contemplando argumentos favoráveis e contrários às práticas da engenharia genética e contribuindo para o raciocínio crítico e sem preconceitos sobre o tema. Por fim, o terceiro capítulo trata da interface entre a bioética e a biossegurança, que têm preocupações comuns, como a questão dos riscos, mas abordagens distintas – enquanto a bioética se ocupa dos valores morais, a biossegurança lança mão de medidas técnicas, administrativas e legais.
    Keywords: R5-920 ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 49
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    Duke University Press | Duke University Press
    Publication Date: 2024-04-02
    Description: In Uneven Encounters, Micol Seigel chronicles the exchange of popular culture between Brazil and the United States in the years between the World Wars, and demonstrates how that exchange affected ideas of race and nation in both countries. From Americans interpreting advertisements for Brazilian coffee or dancing the Brazilian maxixe, to Rio musicians embracing the “foreign” qualities of jazz, Seigel traces a lively, cultural back and forth. Along the way, she shows how race and nation for both elites and non-elites are constructed together, and driven by global cultural and intellectual currents as well as local, regional, and national ones. Seigel explores the circulation of images of Brazilian coffee and of maxixe in the United States during the period just after the imperial expansions of the early twentieth century. Exoticist interpretations structured North Americans’ paradoxical sense of themselves as productive “consumer citizens.” Some people, however, could not simply assume the privileges of citizenship. In their struggles against racism, Afro-descended citizens living in Rio de Janeiro, São Paulo, New York, and Chicago encountered images and notions of each other, and found them useful. Seigel introduces readers to cosmopolitan Afro-Brazilians and African Americans who rarely traveled far from home but who nonetheless absorbed ideas from abroad. She suggests that studies comparing U.S. and Brazilian racial identities as two distinct constructions are misconceived. Racial formation transcends national borders; attempts to understand it must do the same.
    Keywords: History ; United States ; 20th Century ; Social Science ; Ethnic Studies ; American ; African American & Black Studies ; History ; Latin America ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies
    Language: English
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  • 50
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
    Language: English
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    SciELO Books - Editora FIOCRUZ
    Publication Date: 2023-12-21
    Description: Unprecedented initiative in the world, the book compiles the available knowledge on the subject and presents the state-of-the-art in paleoparasitology – term coined about 30 years ago by Brazilian Fiocruz researcher Luiz Fernando Ferreira, pioneer in this science which is concerned with the study of parasites in the past. Multidisciplinary by essence, paleoparasitology gathers contributions from social scientists, biologists, historians, archaeologists, pharmacists, doctors and many other professionals, either in biomedical or humanities fields. With varied applications such as in evolutionary or migration studies, their results often depend on the association between laboratory findings and cultural remains. The book is divided into four parts - Parasites, Hosts, and Human Environment; Parasites Remains Preserved in Various Materials and Techniques in Microscopy and Molecular Diagnostics; Parasite Findings in Archeological Remains: a paleographic view; and Special Studies and Perspectives. Signed by authors from various countries such as Argentina, USA, Germany and France, the book has chapters devoted to the discoveries of paleoparasitology on all continents.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: English
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  • 52
    Publication Date: 2024-04-02
    Description: Translating Early Modern Science explores the roles of translation and the practices of translators in early modern Europe. In a period when multiple European vernaculars challenged the hegemony long held by Latin as the language of learning, translation assumed a heightened significance. This volume illustrates how the act of translating texts and images was an essential component in the circulation and exchange of scientific knowledge. It also makes apparent that translation was hardly ever an end in itself; rather it was also a livelihood, a way of promoting the translator’s own ideas, and a means of establishing the connections that in turn constituted far-reaching scientific networks.
    Keywords: History ; Europe ; Medieval ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 53
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
    Language: English
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  • 54
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    Liverpool University Press
    Publication Date: 2024-04-02
    Description: The theme of this book is cultural encounter and exchange in Irish women’s lives. Using three case studies: the Enlightenment, emigration and modernism, it analyses reading and popular and consumer culture as sites of negotiation of gender roles. It traces how the circulation of ideas, fantasies and aspirations which have shaped women’s lives in actuality and in imagination and argues that there were many different ways of being a woman. Attention to women’s cultural consumption and production shows that one individual may in one day identify with representations of heroines of romantic fiction, patriots, philanthropists, literary ladies, film stars, career women, popular singers, advertising models and foreign missionaries. The processes of cultural consumption, production and exchange provide evidence of women’s agency, aspirations and activities within and far beyond the domestic sphere.
    Keywords: History ; Catholic Church ; Dublin ; Ireland ; London ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 55
    Publication Date: 2023-12-21
    Description: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Keywords: R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
    Language: English
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  • 56
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    University of California Press | University of California Press
    Publication Date: 2024-03-24
    Description: To produce the song sequences that are central to Indian popular cinema, singers' voices are first recorded in the studio and then played back on the set to be lip-synced and danced to by actors and actresses as the visuals are filmed. Since the 1950s, playback singers have become revered celebrities in their own right. Brought to Life by the Voice explores the distinctive aesthetics and affective power generated by this division of labor between onscreen body and offscreen voice in South Indian Tamil cinema. In Amanda Weidman's historical and ethnographic account, playback is not just a cinematic technique, but a powerful and ubiquitous element of aural public culture that has shaped the complex dynamics of postcolonial gendered subjectivity, politicized ethnolinguistic identity, and neoliberal transformation in South India.
    Keywords: Music ; Ethnomusicology ; History ; Asia ; India & South Asia ; Social Science ; Anthropology ; Cultural & Social ; thema EDItEUR::A The Arts::AV Music::AVA Theory of music and musicology ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology
    Language: English
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  • 57
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    Éditions de l'Université de Bruxelles
    Publication Date: 2024-04-01
    Description: Depuis la gouvernance de Marie de Hongrie, les Gouverneurs généraux chargés de l’administration de nos provinces avaient pour habitude de s’installer à Bruxelles. Pour leur confort et celui de l’importante Cour qui les entourait, le Souverain avait mis à leur disposition l’ensemble de ses biens immobiliers en Brabant. Ces châteaux, maisons, parcs, viviers et autres étaient entretenus à grands frais par une institution spécialement mise en place dans ce but : le Bureau des ouvrages de la Cour. Méconnu jusqu’à présent, cet organisme constituait toutefois une pièce maîtresse dans l’organisation de la vie quotidienne de la Cour de Bruxelles. Les compétences de cette institution ainsi que le personnel qui la composait ont été étudiés à partir des instructions et règlements édictés pour ce département. Ces directives ont ensuite été confrontées aux activités quotidiennes du Bureau pour déterminer dans quelle mesure elles étaient appliquées et/ou adaptées. Enfin, les difficultés éprouvées par ce département dans la gestion de ses affaires ont également été analysées. Grâce à cette étude, un portrait relativement complet du Bureau des ouvrages de la Cour a donc pu être dressé, permettant ainsi de le situer parmi les autres institutions centrales du gouvernement autrichien.
    Keywords: History ; thema EDItEUR::N History and Archaeology::NH History
    Language: French
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    University of California Press | University of California Press
    Publication Date: 2024-04-02
    Description: Since the 2001 overthrow of the Taliban government in Afghanistan, violence against women has emerged as the single most important issue for Afghan gender politics. The Pitfalls of Protection, based on research conducted in Afghanistan between 2009 and 2015, locates the struggles over gender violence in local and global power configurations. Torunn Wimpelmann finds that aid flows and geopolitics have served as both opportunities for and obstacles to feminist politics in Afghanistan. Showing why Afghan activists often chose to use the leverage of Western powers instead of entering into either protracted negotiations with powerful national actors or broad political mobilization, this book examines both the achievements and the limits of this strategy.
    Keywords: History ; General ; History ; Historical Geography ; Social Science ; General ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTP Historical geography ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general
    Language: English
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  • 59
    Publication Date: 2024-04-08
    Description: Remains of the Social is an interdisciplinary volume of essays that engages with what ‘the social’ might mean after apartheid; a condition referred to as ‘the post-apartheid social’. The volume grapples with apartheid as a global phenomenon that extends beyond the borders of South Africa between 1948 and 1994 and foregrounds the tension between the weight of lived experience that was and is apartheid, the structures that condition that experience and a desire for a ‘post-apartheid social’ (think unity through difference). Collectively, the contributors argue for a recognition of the ‘the post-apartheid’ as a condition that names the labour of coming to terms with the ordering principles that apartheid both set in place and foreclosed. The volume seeks to provide a sense of the terrain on which ‘the post-apartheid’ - as a desire for a difference that is not apartheid’s difference - unfolds, falters and is worked through.
    Keywords: History ; Apartheid ; Empathy ; Hannah Arendt ; Nelson Mandela ; Psychoanalysis ; Sigmund Freud ; South Africa ; bic Book Industry Communication::H Humanities::HP Philosophy::HPS Social & political philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy
    Language: English
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  • 60
    Publication Date: 2024-04-01
    Description: A synoptic interpretation of the rulers and elites in Eurasia from the fourteenth to the eighteenth century. Readership: All interested in the early modern global and comparative history of kingdoms and empires, rulers and elites, including area specialists as well as generalists. This book is intended for students and scholars.
    Keywords: History ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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  • 61
    Publication Date: 2023-12-21
    Description: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis.
    Keywords: R5-920 ; RC581-607 ; Schistosomiasis ; Schistosoma mansoni ; Schistosoma haematobium ; Type 2 cytokines ; Vaccine ; Immune responses ; Schistosoma japonicum ; Vaccine candidates ; bic Book Industry Communication::M Medicine
    Language: English
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  • 62
    Publication Date: 2023-12-21
    Description: In the perioperative setting and in intensive care medicine, early and effective hemodynamic management including fluid therapy and administration of vasoactive drugs to maintain vital organ perfusion and oxygen delivery is mandatory. Understanding the different approaches in the management of critically ill patients during the resuscitation and further management is essential to initiate adequate context- and time-specific interventions. Optimization of hemodynamic variables to achieve a balance between organ oxygen delivery and consumption is a cornerstone. In general, cardiac output (i.e., the blood flow) is considered a major determinant of oxygen supply and thus its monitoring is regarded helpful. However, indicators of oxygen requirements are equally necessary to assess adequacy of oxygen supply. Currently, more and more less or even totally non-invasive monitoring systems have been developed and clinically introduced, but they require validation in particular clinical settings. Cardiac output monitors and surrogates of organ oxygenation only enable to adequately guide management, as patient’s outcome is determined by acquisition and interpretation of accurate measurements, and finally, suitable management decisions. This Research Topic focuses on the currently available techniques, especially the less and non-invasive ones, in the field of hemodynamic monitoring in the perioperative setting and in critically ill patients while summarizing their advantages and limitations.
    Keywords: R5-920 ; Blood Pressure ; Cardiovascular dynamics ; goal-directed therapy ; intensive care medicine ; Cardiac Output ; Anesthesiology ; bic Book Industry Communication::M Medicine
    Language: English
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  • 63
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    University of London Press | University of London Press | University of London Press
    Publication Date: 2024-04-11
    Description: This collection addresses the concept of gender in the middle ages through the study of place and space, exploring how gender and space may be mutually constructive and how individuals and communities make and are made by the places and spaces they inhabit. From womb to tomb, how are we defined and confined by gender and by space? Interrogating the thresholds between sacred and secular, public and private, enclosure and exposure, domestic and political, movement and stasis, the essays in this interdisciplinary collection draw on current research and contemporary theory to suggest new destinations for future study.
    Keywords: History ; Europe ; Great Britain ; Norman Conquest To Late Medieval (1066-1485) ; Technology & Engineering ; Agriculture ; bic Book Industry Communication::H Humanities::HB History::HBL History: earliest times to present day::HBLC Early history: c 500 to c 1450/1500
    Language: English
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  • 64
    Publication Date: 2023-12-21
    Description: Uma das particularidades da área da saúde é pertencer tanto à esfera social quanto à industrial, característica que representa oportunidades e grandes desafios. O livro Medicamentos no Brasil: inovação e acesso tem o objetivo de fomentar o desenvolvimento tecnológico e fortalecer a produção nacional, além de garantir que o conhecimento desses avanços beneficie a população brasileira. Como afirma o ministro da Saúde, José Gomes Temporão, no prefácio: “...inovação não pode estar desligada da idéia de acesso”. Reunindo os pontos de vista da academia, governo e setor produtivo público e privado, com abordagens que privilegiam o contexto nacional e refletem sobre a posição brasileira no cenário internacional, a obra apresenta um diagnóstico da área de medicamentos no país, avalia seus problemas e potencialidades e faz recomendações concretas para superação dos obstáculos e aproveitamento das oportunidades. Cabe destacar que é o segundo volume de uma série sobre pesquisa, desenvolvimento e inovação nos segmentos industriais da saúde, do Projeto Inovação em Saúde (presidência/Fiocruz), cujo primeiro livro é Vacinas, Soros e Imunizações no Brasil.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
    Keywords: R5-920 ; RM1-950 ; n/a ; biomaterial ; redifferentiation ; regenerative medicine ; skeletal muscle regeneration ; furcation defects ; Platelet-Rich Plasma (PRP) ; PRP ; fracture ; fibrin sealant ; periodontal surgery ; bone regeneration ; serum derived from plasma rich in growth factors (s-PRGF) ; cartilage repair ; myofibroblasts ; autologous platelet concentrates ; burns ; satellite cells ; articular cartilage ; stem cell niche ; wound healing ; quantification ; growth factors ; biologics ; platelet rich plasma ; meniscus ; adipose tissue ; Carprofen ; platelet-rich fibrin ; platelets ; hyperacute serum ; bone defects ; serum eye drops ; corneal epithelial defect ; fibrosis ; dog ; myoblasts ; differentiation ; chronic meniscal lesion ; horizontal meniscal tear ; PRGF ; collagen hydrogels ; periodontal defects ; bone grafting material ; composition ; cell therapy ; bone healing ; tissue healing ; trephination ; plasma rich plasma (PRP) ; bone repair ; plasma rich in growth factors ; knee arthrosis ; meniscus tear ; cornea regeneration ; wrist osteoarthritis ; periosteal sheet ; Platelet-Poor Plasma (PPP) ; platelet-rich plasma ; microfat ; bone grafting ; hyaluronic acid (NaHA) ; periodontal regeneration ; meniscus repair ; photobiomodulation therapy ; growth ; myogenesis ; blood derived products ; low-level laser therapy ; bic Book Industry Communication::M Medicine
    Language: English
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  • 66
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    transcript Verlag
    Publication Date: 2024-04-04
    Description: To Be Unfree is a collection of essays investigating how political unfreedom has been and can be articulated within the republican tradition of political thought. The book combines a theoretical discussion of how freedom and its opposites have been conceptualized in the republican tradition with a broader perspective on this tradition's impact on the representation of unfreedom in Western literature and cultural history. It thus complicates our understanding of what it means to be unfree and unveils a series of distinctions which also shape our modern notions of freedom.
    Keywords: Political Science ; Republicanism ; Political Theory ; History ; Liberty ; Cultural History ; Politics ; Political Philosophy ; Political Ideologies ; Political Science ; Democracy ; Hannah Arendt ; Quakers ; Thomas Hobbes ; Unfreedom ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: English
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  • 67
    Publication Date: 2023-12-21
    Description: Looking at "Horse in Motion", the iconic photograph by E. Muybridge, it is almost possible to hear the horse galloping. The pounding sound of the hoofs hitting the ground -like a drum- can also echo the rythmic beating of the human heart. That sound, that visceral rhythm, reminds us of the link between motion and performance: the perfectly executed stride of the horse, the incredible coordination of multiscale phenomena behind a heart beat. Furthermore, the decomposed sequence in Muybridge's photograph has become a well-known example of breaking motion into its components over time, and as such is reminiscent of those images that are routinely acquired in clinical practice, where the heart appears dilating and shirnking in a sequence of snapshots. The investigation of this motion and its subtleties is essential for refining our understanding of cardiac function, and the appreciation of how and when this motion is no longer perfectly executed can lead us to understand functional impairments and provide insight into the unfolding of pathology. In the presence of congenital heart disease (CHD), cardiac mechanics are altered: from single ventricle physiology to conduction abnormalities to different cardiomyopathies, it is important to both capture and interpret biomechanical changes that occur in the presence of a congenital defect. This special issue in Frontiers in Pediatrics, now an e-book, focuses on 'Ventricular mechanics in congenital heart disease' and looks at current knowledge of phenomena such as systolic/diastolic dysfuction and current methods (chiefly in cardiovascular magnetic resonance imaging and echocardiography) to evaluate cardiac function in the presence of CHD, and then presents a series of original studies that employ both medical imaging and computational modelling techniques to study specific CHD scenarios.
    Keywords: R5-920 ; RJ1-570 ; cardiovascular magnetic resonance imaging ; ventricular mechanics ; Congenital Heart Diseases ; hypoplastic left heart syndrome ; diastolic function ; computational modelling ; systolic function ; haemodynamics ; bic Book Industry Communication::M Medicine
    Language: English
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  • 68
    Publication Date: 2024-04-01
    Description: In Authoritarian Modernization in Indonesia’s Early Independence Period, Farabi Fakih offers a historical analysis of the foundational years leading to Indonesia’s New Order state (1966–1998) during the early independence period. The study looks into the structural and ideological state formation during the so-called Liberal Democracy (1950–1957) and Sukarno’s Guided Democracy (1957–1965). In particular, it analyses how the international technical aid network and the dominant managerialist ideology of the period legitimized a new managerial elite. The book discusses the development of managerial education in the civil and military sectors in Indonesia. The study gives a strongly backed argument that Sukarno’s constitutional reform during the Guided Democracy period inadvertently provided a strong managerial blueprint for the New Order developmentalist state. Readership: All those interested in the political history of Indonesia, the history of the developmental state and the history of managerial ideology.
    Keywords: History ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    SciELO Books - Editora FIOCRUZ
    Publication Date: 2023-12-21
    Description: A autora apresenta uma análise que vai da lógica da compaixão à lógica utilitarista, modalidades diferenciadas de intervenção sobre a saúde das pessoas e coletividades no século XIX e que, apesar de aparentemente antagônicas, estão mais próximas do que se possa imaginar. Analisa as motivações éticas a partir das quais se legitimaram diversas modalidades de assistência médica aos necessitados. Examina, também, a história de certas práticas e estratégias - a transformação do hospital em espaço médico, o papel da caridade e da filantropia e o nascimento da família moderna como agente de controle médico das populações. Constitui-se, assim, importante reflexão sobre os limites das duas estratégias das políticas assistenciais
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 70
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    De Gruyter Oldenbourg
    Publication Date: 2024-04-04
    Description: Ten million soldiers died during the First World War. But why, and for what reason? The Great War is widely seen as a "pointless carnage" (Pope Benedict XV). Was there a point, at least in the eyes of the political and military decision makers? International specialists analyse the hopes and expectations of the political and military leaders and try to explain why the contemporaries thought that they had to fight the Great War.
    Keywords: History ; History ; World War 1 ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR5 First World War ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBF c 1910 to c 1919::3MPBFB c 1914 to c 1918 (World War One period)
    Language: English
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  • 71
    Publication Date: 2022-01-31
    Description: Thyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormone, have not been a priority within the field. This is changing mainly for two reasons. First, new genetic diseases have been discovered, altering thyroid hormone signaling in brain (THRA, MCT8, SBP2), with neurodevelopmental consequences which are currently incurable. Second, there is a growing concern that exposition of the general population to environmental chemicals able to interfere with thyroid hormone signaling compromises children neurodevelopment or induces central disorders in adults. Finally thyroid hormone is acting directly on gene transcription, by binding nuclear receptors, and therefore is an interesting entry point to identify genetic programs controlling brain development and function. Reaching a broad understanding of the multiple processes involving thyroid hormone in brain is a tremendous task which will necessitate a multidisciplinary approach: animal genetics, molecular biology, brain imaging, developmental biology, genomics, etc... This topic will be the occasion to combine recent contributions in the field and to identify priorities for future investigations. Due to devastating consequences of congenital hypothyroidism, the neurodevelopmental consequences of altered thyroid hormone signaling have been extensively studied over the years. The discovery of new genetic diseases, the concern about the possible neurotoxicity of environmental thyroid hormone disruptors, recently renewed the interest for an important research field. This Ebook gathers reviews and original data from experts in various disciplines. It provides a broad view of ongoing research and outlines key issues for future investigation.
    Keywords: RC648-665 ; R5-920 ; thyroid hormone ; neurodevelopment ; transporter ; nuclear receptor ; brain ; deiodinase
    Language: English
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  • 72
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    UCT Press
    Publication Date: 2022-04-28
    Description: The Cape Flats, a windswept, barren and sandy area which rings Cape Town, is home to more than a million people. Many live here in sprawling shack settlements. The post-apartheid state is attempting to eradicate such settlements by providing formal houses in planned residential estates. Raw Life, New Hope is a longitudinal study of the residents of one such shack settlement, The Park, who moved to new, 'formal' houses in The Village, at the turn of the millennium. It introduces readers to core social science topics and modes of theorising. Over 17 years the author has traced how ordinary people attempt to live in accord with their ideals of decency under almost impossible circumstances, and the effects of material changes in their lives after 1994, including the provision of housing. Photos, maps, anecdotes, recipes and philosophical reflections on subjects that arose during conversations elicit a sense of the everyday and of how people try to solve the problems of poverty.
    Keywords: History ; informal settlements ; shack settlements,Cape Flats ; post-apartheid state ; formal housing ; longitudinal study ; Everyday life ; HIV ; HIV/AIDS ; Social relation ; South Africa ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology::JHMC Social & cultural anthropology, ethnography
    Language: English
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    Fordham University Press
    Publication Date: 2023-02-01
    Description: From the eighteenth-century abolitionist motto Am I Not a Man and a Brother? to the Civil Rights-era declaration I AM a Man, antiracism has engaged in a struggle for the recognition of the humanness of black humanity. It has done so, however, during an era in which the very definition of the human has been called into question by the rising prestige of the biological sciences whose materialist account of human being erodes the grounds of human exceptionalism...Antislavery materialism allowed these authors to respond to scientific racism in its own empirical terms. At the same time, however, it also attenuated their faith in the liberal humanist principles that they champion elsewhere in their work. This antebellum conflict between the liberal ideals of freedom and a materialist ontology of contingency not only presages current critical debates between new materialist and social justice theorists, but reveals an intrinsic tension between posthumanism’s embodied ontology and the...
    Keywords: History ; Slavery ; Antislavery ; Racial Science ; Biopolitics ; Posthumanism ; New Materialism ; Nonhuman ; Frederick Douglass ; Henry David Thoreau ; Walt Whitman ; Liberalism ; Ontology ; Racism ; Scientific racism ; Spiritualism
    Language: English
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    University of London Press | University of London Press
    Publication Date: 2024-04-01
    Description: Medieval Londoners were a diverse group, some born in the city, and others drawn to the capital from across the realm and from overseas. For some, London became the sole focus of their lives, while others retained or developed networks and loyalties that spread far and wide. The rich evidence for the medieval city, including archaeological and documentary evidence, means that the study of London and its inhabitants remains an active field. Medieval Londoners brings together archaeologists, historians, art historians and literary scholars whose essays provide glimpses of medieval Londoners in all their variety. This volume is offered to Caroline M. Barron, Emeritus Professor of the History of London at Royal Holloway, University of London, on the occasion of her 80th birthday. Her remarkable career – over some fifty years – has revitalized the way in which we consider London and its people. This volume is a tribute to her scholarship and her friendship and encouragement to others. It is thanks to Caroline M. Barron that the study of medieval London remains as vibrant today as it has ever been.
    Keywords: History ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    De Gruyter
    Publication Date: 2024-04-08
    Description: RGVV(History of Religion: Essays and Preliminary Studies) brings together the mutually constitutive aspects of the study of religion(s)—contextualized data, theory, and disciplinary positioning—and engages them from a critical historical perspective. The series publishes monographs and thematically focused edited volumes on specific topics and cases as well as comparative work across historical periods from the ancient world to the modern era.
    Keywords: Religion ; History ; bic Book Industry Communication::H Humanities::HR Religion & beliefs ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general::HRAC Comparative religion ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAC Comparative religion
    Language: English
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    University of Hawai'i Press
    Publication Date: 2022-05-02
    Description: The overwhelming majority of tea practitioners in contemporary Japan are women, but there has been little discussion on their historical role in tea culture (〈i〉chanoyu〈/i〉). In 〈i〉Cultivating Femininity,〈/i〉 Rebecca Corbett writes women back into this history and shows how tea practice for women was understood, articulated, and promoted in the Edo (1603–1868) and Meiji (1868–1912) periods. Viewing 〈i〉chanoyu〈/i〉 from the lens of feminist and gender theory, she sheds new light on tea’s undeniable influence on the formation of modern understandings of femininity in Japan. 〈i〉Cultivating Femininity 〈/i〉offers a new perspective on the prevalence of tea practice among women in modern Japan. It presents a fresh, much-needed approach, one that will be appreciated by students and scholars of Japanese history, gender, and culture, as well as by tea practitioners.
    Keywords: History ; History ; chanoyu ; Japanese tea culture ; modernity ; practice ; Daimyo ; Edo ; Edo period ; Ii Naosuke ; Meiji (era) ; Shoo
    Language: English
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  • 77
    Publication Date: 2023-12-21
    Description: Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition, NAbs play a role in preventing the expansion of specific auto-reactive clones, thereby behaving as regulatory elements in acute or chronic inflammation. To maintain the non-pathogenic balance between the dual pathogen/self-antigen cross-reactivities of NAbs, a strict regulation in NAb secretion and function is necessary to avoid autoimmune disease. Actually, some of the NAbs related auto-reactivities, such as anti-DNA and anti-MOG, have been associated with autoimmunity. Furthermore, NAbs have been shown to bind to ‘neo-self’ carbohydrate antigens on glycolipids and glycoproteins found on malignant but not normal cells, which suggests NAbs may take part in tumor immunosurveillance. Many aspects regarding NAbs have yet to be studied in more detail: the reactivity and function of NAbs in health and disease, the behavior of the NAb repertoire with increasing age, the regulation of natural antibody production and auto-reactivity, the ways to specifically activate NAbs producing cells with desired specificities, the characteristics of human NAbs, among others. This special topics eBook consists of a number of articles exploring the cells that produce NAbs as well as the characteristics, function, specificity, and/or the role of natural antibodies in health and disease.
    Keywords: R5-920 ; RC581-607 ; innate immunity ; immunoglobulin ; Antibodies ; B cells ; IgM ; natural antibodies ; B-1 cells ; bic Book Industry Communication::M Medicine
    Language: English
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    Böhlau
    Publication Date: 2024-04-01
    Description: Digitale Technologien und Methoden haben in den vergangenen Jahren immer mehr Einfluss auf die geisteswissenschaftliche Forschung gewonnen. Dies gilt nicht minder fur das achtzehnte Jahrhundert: In allen einschlagigen Fachbereichen werden seit Jahren Texte, Bilder und Metadaten digital generiert, verarbeitet, analysiert und prasentiert. Ergebnis ist eine bisher nie dagewesene Konfrontation mit quantifizierenden Methoden auch in qualitativ arbeitenden Disziplinen sowie die Notwendigkeit einer Auseinandersetzung mit nationalen und globalen Datenstandards. Diese Standards entscheiden uber die Interoperabilitat - gewissermassen die internationale Anschlussfahigkeit - der Daten und somit uber die Nachhaltigkeit der eigenen Forschung. Die Osterreichische Gesellschaft zur Erforschung des achtzehnten Jahrhunderts widmet ihr 34. Jahrbuch 2019 dem Thema der digitalen Forschung zum 18. Jahrhundert in Zentraleuropa. Die einzelnen vorgestellten Beitrage sind nicht nur Projektberichte, sondern referieren die Ergebnisse digital durchgefuhrter Forschungsarbeit. Sie eroffnen ein Panorama der moglichen methodischen Zugange, von den Bildwissenschaften uber Netzwerkanalyse und -darstellung hin zu digitaler Edition, Korpuslinguistik und digitaler Sprachwissenschaft sowie der Vernetzung von Forschungsdaten mit den Daten von Kulturerbe-Institutionen.
    Keywords: History ; General ; thema EDItEUR::N History and Archaeology::NH History
    Language: German
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  • 79
    Publication Date: 2023-12-21
    Description: The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values.〈/p〉〈p〉A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. 〈/p〉〈p〉Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome.〈/p〉〈p〉A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment.〈/p〉〈p〉Considerable progress has been made in this respect in the following key areas:〈/p〉〈p〉• the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure,〈/p〉〈p〉• the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects,〈/p〉〈p〉• the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression,〈/p〉〈p〉• the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates,〈/p〉〈p〉• the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load.〈/p〉〈p〉This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
    Keywords: R5-920 ; RC648-665 ; relational stability ; Thyronamines ; TSH-T3 Shunt ; thyroid allostasis ; precision medicine ; Stratified Medicine ; 3-T1AM ; Hypothyroidism ; Thyroid homeostasis ; Hysteresis ; bic Book Industry Communication::M Medicine
    Language: English
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  • 80
    Publication Date: 2023-12-21
    Description: Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core domains of social and communication dysfunction. The pathogenesis paradigm shift of ASD towards synaptic abnormalities moved the research to pathway to disease that involve multiple systems and that are becoming the forefront of ASD treatment and are pointing toward the development of new targeted treatments. Some new therapeutics have been tested and others are being studied. In this context single gene disorders frequently associated with ASD such as Rett Syndrome, Fragile X and Tuberous Sclerosis have been of significant aid as neurobiology of these disorders is more clear and has a potential to shed light on the altered signaling in ASD. However much research is needed to further understand the basic mechanisms of disease and the relationship to idiopathic ASD. Clinical trials in children are underway with agents directed to core symptoms and to the associated disorders in the search of new therapeutics and progress are expected with possible new option for therapeutics in ASD in the upcoming future. Children and Adolescents with ASD and their families can provide important information about their experience with new treatments and this should be a priority for future research. In addition, research performed on genetic mouse models of ASD will keep on providing useful information on the molecular pathways disrupted in the disease, thus contributing to identify novel drug targets.
    Keywords: R5-920 ; RJ1-570 ; Clinical Trial ; mouse model ; neurodevelopmental disorder ; Genetics ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 81
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    Böhlau
    Publication Date: 2024-04-02
    Description: Die vielfältigen Formen des Musizierens in der österreichischen Zwischenkriegszeit wurden in Konflikten um legitime und illegitime Musizierpraktiken immer wieder neu verhandelt. Im Zusammenhang zeitgenössischer Kategorien der Neudefinition und Neuorganisation von Arbeit mit technischen Entwicklungen und neuen Musikgenres wurden unterschiedliche Musizierformen höchst unterschiedlich praktiziert und behandelt. Durch eine systematische Analyse der Beziehungen zwischen Musizierformen, die bislang meist nur getrennt untersucht wurden, werden Hierarchien von Musizieren und Musizierenden zwischen (Nicht-)Kunst und (Nicht-)Beruflichkeit klar, die teilweise auch Jahrzehnte danach noch öffentliche Wahrnehmungen und wissenschaftliche Kategorisierungen von Musik beeinflussten.
    Keywords: History ; Wirtschaftsgeschichte ; Sozial- und Kulturgeschichte ; Österreich ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: German
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  • 82
    Publication Date: 2023-12-21
    Description: Peut-on évaluer le risque d’avoir une maladie en lien avec nos gènes, nos comportements ou notre environnement ? L’épidémiologie, qui étudie la répartition et les déterminants des maladies dans la population, permet de répondre à ces questions. Le développement fulgurant de cette science, dans la seconde moitié du xxe siècle, a permis de faire des progrès considérables dans l’identification des facteurs de risque des maladies cardiovasculaires et de nombreux cancers. Les progrès du séquençage du génome humain au début du xxie siècle et, d’une façon plus générale, l’accès aux données massives (big data), ont révolutionné la recherche en épidémiologie tout en lui imposant de nouveaux défis scientifiques et éthiques.
    Keywords: R5-920 ; maladies ; science ; santé ; épidémies ; épidémiologie ; estimation du risque ; santé publique ; bic Book Industry Communication::M Medicine
    Language: French
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  • 83
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    Böhlau
    Publication Date: 2024-04-01
    Description: The Balkans and the Near East share millennia of a shared history, which stretches from sedentarization in early history to the 20th century. In the Neolithic period, in Mesopotamia and in the Balkans basic techniques and skills were developed on which Europe and the Islamic world could be based later on. Thus, for example, in the centres of "Ancient Europe" - in the middle basin of the Danube River - already in the 5th millennium people experimented with early script systems, long before the first cuneiform texts in Mesopotamia and the hieroglyph texts in ancient Egypt became in use. The "division of labour" between the various scholarly disciplines in the fields of Balkan studies and Near (Middle) East studies resulted in the separation of a shared history into a Southeast European or Balkan history on the one hand and a history of the Near (Middle) East on the other hand. It is therefore the aim of the monograph to unite the separated histories to a joint one. Since this cannot be done by the simple operation of adding up two histories, the volume opens new perspectives. A comparable historiographical piece of work does not yet exist. The geographical space covered by the text extends between Bosnia in the west, the Iraq in the east and the Arabic Peninsula and Egypt in the south. The composition of the material is based on regional and temporal comparison. Specifically, temporal comparison constitutes a great challenge, because approximately 10,000 years are covered. The book is organized by topics and comprises 17 chapters, 455 manuscript pages and approximately 120 graphs and photographs. Conceptualized as an introductory text, the book may also interest a wider public. The style of writing is generally intelligible and addresses for instance the burning contemporary tensions between Islam and Europe. In addition, topics such as history of religion, historical-anthropological, economic, cultural as well as questions of gender relations are addressed on a principal basis.
    Description: Der Balkan und der Nahe Osten teilen eine Tausende von Jahren währende gemeinsame Geschichte, die von der Sesshaftwerdung in der Frühgeschichte bis in das 20. Jahrhundert reicht. In Mesopotamien und auf dem Balkan wurden in der Jungsteinzeit jene Techniken und Fertigkeiten entwickelt, auf denen später Europa und die islamische Welt aufbauen konnten. So wurde beispielsweise in den Zentren "Alteuropas" - entlang der mittleren Donau - ab dem 5. Jahrtausend bereits mit frühen Schriftsystemen experimentiert, ehe die ersten Keilschrifttexte in Mesopotamien und die Hieroglyphenschrift Ägyptens entwickelt werden sollte. Die "Arbeitsteilung" zwischen einzelnen Wissenschaftsdisziplinen hat es mit sich gebracht, dass diese gemeinsame Geschichte immer wieder aufs Neue gesondert geschrieben wurde: einerseits als Geschichte des Balkans oder des südöstlichen Europa, andererseits als Geschichte des Nahen Ostens. Das zur Publikation anstehende Buch hat das Ziel, diese gesondert betrachteten Geschichten zu einer gemeinsamen zusammenzuführen und entwirft somit eine völlig neue Perspektive. Eine vergleichbar konzipierte Darstellung wurde noch nicht unternommen. Geografisch gesehen erstreckt sich die Darstellung zwischen Bosnien im Westen, dem Irak im Osten und der Arabischen Halbinsel und Ägypten im Süden. Die Darstellung des Stoffes ist auf regionalen und temporalen Vergleichen aufgebaut. Insbesondere der temporale Vergleich stellt eine Herausforderung dar, weil der Zeitraum ca. 10000 Jahre umfasst. Das nach Themenbereichen geordnete Buch ist in 17 Kapitel gegliedert und umfasst 455 Manuskriptseiten mit rund 120 Abbildungen. Als eine Einführung für Studierende konzipiert, kann das Werk auch ein allgemein interessiertes Publikum ansprechen. Der Text ist allgemein-verständlich gehalten und geht insbesondere auch auf das gegenwärtige Spannungsverhältnis zwischen dem Islam und Europa ein. Des Weiteren werden religionsgeschichtliche, historisch-anthropologische, ökonomische, kulturelle wie auch Fragen der Geschlechtergeschichte grundsätzlich beleuchtet.
    Keywords: Balkans ; History ; Near East ; Religion ; Gender ; Historical Anthrolpology ; Osmanisches Reich ; thema EDItEUR::N History and Archaeology::NH History
    Language: German
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  • 84
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    SciELO Books - Editora FIOCRUZ
    Publication Date: 2024-03-31
    Description: Esta coletânea é especialmente voltada para os profissionais que trabalham na rede do SUS – e pode ser somada a uma proposta de educação a distância. Aborda desde um panorama geral da saúde, no país e no mundo, até os aspectos mais técnicos da tuberculose, como diagnóstico, tratamento e prevenção. Segundo a OMS, o Brasil é um dos 22 países com alta carga de tuberculose e onde o enfrentamento da doença deve ser considerado prioridade. O livro sustenta uma capacitação baseada não só em questões técnicas, mas também em reflexões sobre os determinantes sociais, econômicos e culturais da doença. O objetivo é articular os conteúdos apresentados com a realidade vivenciada pelos profissionais nos serviços de saúde. A 1ª edição é de 1987 e, de lá para cá, o livro já sofreu sucessivas atualizações, envolvendo o Ministério da Saúde, a UFRJ e a Sociedade Brasileira de Pneumologia e Tisiologia, além do Centro de Referência Professor Hélio Fraga (CRPHF), que coordena o trabalho desde o início dos anos 1990. Entre as novidades desta 7ª edição, destacam-se glossário, textos complementares e um projeto gráfico diferenciado para facilitar a leitura e o estudo.
    Keywords: R5-920 ; MEDICAL ; thema EDItEUR::M Medicine and Nursing
    Language: Portuguese
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  • 85
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    Brill | Brill
    Publication Date: 2024-04-01
    Description: Focusing on the native ceramic technology of central Mexico during the early colonial period and the present-day, this book offers a refreshing view into the process of cultural continuity and change in the indigenous Mesoamerican world after the Spanish conquest. Readership: All those interested in sixteenth century colonialism, the colonial period in Middle America, material culture, ancient and present-day ceramics, as well as in cultural continuity and change.
    Keywords: History ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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  • 86
    Publication Date: 2023-12-21
    Description: Population aging and the associated burden of chronic diseases are one of the main challenges in public health worldwide. This Research Topic on "Active Aging and Disease Management" provides a comprehensive overview of population aging through fourteen comprehensive papers. Chapter 1 discusses an overview of health systems in active and healthy aging, while Chapter 2 focuses on the role of lifestyles, exercise and new technologies. Chapter 3 debates psychological and cognitive issues in aging and finally in Chapter 4, an older people self assessment is proposed and the role of communities and supporters are highlighted. We think that real social and health care integration at community level could be the key point to deliver effective health promotion and preventive intervention. Enjoy the reading!
    Keywords: R5-920 ; preventing disability ; dietary intake ; Active aging ; chronic diseases ; Life styles ; Mental Health ; Disease Management ; New technologies ; Elderly ; physical activity ; bic Book Industry Communication::M Medicine
    Language: English
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  • 87
    Publication Date: 2023-12-21
    Description: There is abundant evidence showing a strong association between trauma exposure, psychotic symptoms, and posttraumatic stress disorder (PTSD). Early trauma exposure contributes to the formation of psychotic symptoms and the development of psychotic disorders or severe mental illnesses such as schizophrenia, bipolar disorder, and treatment-refractory major depression. Furthermore, among persons with psychotic disorders, multiple traumatization over the lifetime is common, due to factors such as social stigma, the criminalization of severe mental illness, and increased vulnerability to interpersonal victimization. In addition to these factors is the traumatic nature of experiencing psychotic symptoms and coercive treatments such as involuntary hospitalization and being placed in seclusion or restraints. Not surprisingly, these high rates of trauma lead to high rates of PTSD in people with psychotic disorders, which are associated with more severe symptoms, worse functioning, and greater use of acute care services. In addition to the impact of trauma on the development of psychotic disorders and comorbid PTSD, traumatic experiences such as childhood sexual and physical abuse can shape the nature of prominent psychotic symptoms such as the content of auditory hallucinations and delusional beliefs. Additionally, traumatic experiences have been implicated in the role of ‘stress responsivity’ and increased risk for transition to psychosis in those identified as being at clinical high risk of developing psychosis. Finally, although the diagnostic criteria for PTSD primarily emphasize the effects of trauma on anxiety, avoidance, physiological over-arousal, and negative thoughts, it is well established that PTSD is frequently accompanied by psychotic symptoms such as hallucinations and delusions that cannot be attributed to another DSM-V Axis I disorder such as psychotic depression or schizophrenia. Understanding the contribution of traumatic experiences to the etiology of psychosis and other symptoms can inform the provision of cognitive behavioral therapy for psychosis, including the development of a shared formulation of the events leading up to the onset of the disorder, as well as other trauma-informed treatments that address distressing and disabling symptoms associated with trauma and psychosis. Until recently the trauma treatment needs of this population have been neglected, despite the high rates of trauma and PTSD in persons with psychotic disorders, and in spite of substantial gains made in the treatment of PTSD in the general population. Fortunately, progress in recent years has provided encouraging evidence that PTSD can be effectively treated in people with psychotic disorders using interventions adapted from PTSD treatments developed for the general population. In contrast to clinician fears about the untoward effects of trauma-focused treatments on persons with a psychotic disorder, research indicates that post-traumatic disorders can be safely treated, and that participants frequently experience symptom relief and improved functioning. There is a need to develop a better understanding of the interface between trauma, psychosis, and post-traumatic disorder. This Frontiers Research Topic is devoted to research addressing this interface.
    Keywords: R5-920 ; RC435-571 ; BF1-990 ; Q1-390 ; Psychosis ; PTSD ; Auditory Hallucinations ; Negative Symptoms ; Childhood Trauma ; Trauma ; Psychological Interventions ; Lived Experience ; bic Book Industry Communication::M Medicine
    Language: English
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  • 88
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    SciELO Books - Editora FIOCRUZ
    Publication Date: 2023-12-21
    Description: A infecção por Toxoplasma gondii é hoje muito disseminada ao redor do mundo, especialmente no Brasil. A coletânea parte da história da descoberta desse parasita e da doença por ele causada, a toxoplasmose, e visita os diferentes aspectos relacionados ao tema. São apresentados o ciclo evolutivo, a epidemiologia, o diagnóstico, o quadro clínico e o tratamento, em uma ampla revisão sobre o assunto, provavelmente a mais completa já realizada. Somente nos anos 1970 desvendou-se o ciclo de vida desse protozoário, do qual o gato é hospedeiro definitivo. Outros animais de sangue quente, entre eles o ser humano, são hospedeiros intermediários. Muitos indivíduos infectados pelo T. gondii não apresentam sintomas, mas, quando a doença se manifesta, pode ter diferentes configurações, afetando gânglios, olhos, coração, pulmões, fígado, cérebro e meninges, ou articulações. Além de uma completa revisão, a obra também traz para o leitor o que há de mais atual no conhecimento científico acerca da toxoplasmose e do T. gondii. O livro cobre praticamente todos os campos do conhecimento sobre o agente etiológico e a doença, apresentando novos aspectos, particularmente em relação à bioquímica, à interação entre o parasita e a célula hospedeira e à resposta imunológica à infecção.
    Keywords: R5-920 ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 89
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    Cornell University Press
    Publication Date: 2024-04-04
    Description: The International Institute of Applied Systems Analysis (IIASA), an international think tank established jointly by the United States and Soviet Union in Austria in 1972, was intended to advance scientific collaboration. Until the late 1980s, the IIASA was one of the very few permanent sites where policy scientists from both sides of the Iron Curtain could work together to articulate and solve world problems, most notably global climate change. One of the best-kept secrets of the Cold War, this think tank was a rare zone of freedom, communication, and negotiation, where leading Soviet scientists could try out their innovative ideas, benefit from access to Western literature, and develop social networks, thus paving the way for some of the key science and policy breakthroughs of the twentieth century.
    Keywords: History ; global climate change ; iron curtain ; cold war ; Cybernetics ; International Institute for Applied Systems Analysis ; Soviet Union ; Systems theory ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTW Cold wars and proxy conflicts
    Language: English
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  • 90
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    Franz Steiner Verlag | Franz Steiner Verlag
    Publication Date: 2024-04-02
    Description: Der Ulmer Arzt Johann Franc (1649–1725) hinterließ unter dem Titel "Ephemeris" eine in ihrer Art einzigartige Sammlung medizinischer Fallbeobachtungen aus seiner Praxis. Von eigener Hand mit einer Fülle farbiger Zeichnungen verziert, schildert Franc in seinen Aufzeichnungen detailreich die Erkrankungen seiner Patientinnen und Patienten, Untersuchungen und Behandlungen. Dabei erscheint der Arzt als streitbarer Gelehrter, der nicht mit Kritik an seinen Ulmer Standeskollegen geizt und sich in beigefügten Kommentaren mit den medizinischen Theorien seiner Zeit auseinandersetzt. Die Autorinnen und Autoren werten die "Ephemeris" unter Berücksichtigung weiterer Zeugnisse zu Johann Francs Leben und Schaffen unter vielfältigen Aspekten aus. Ihre Analysen vermitteln ein anschauliches Bild des medizinischen Alltags in Ulm um 1700 und decken Francs Vernetzung im innerstädtischen wie territorialen Kontext auf.
    Keywords: History ; Europe ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: German
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  • 91
    Publication Date: 2023-12-21
    Description: The brainstem-limbic regions, including the superior colliculus, pulvinar and amygdala, receive direct perceptual information as a rapid, coarse, subcortical sensory system bypassing early sensory cortical systems, and play a central role in innate behaviors, including motivated and avoidance behaviors. Recent human neuropsychological studies including those on cortical blindness suggest that these subcortical sensory pathways are functional in the intact human brain and interact with more evolutionary recent cortical systems. This eBook presents up-to-date advancements in this area and to highlight the functions of the brainstem-limbic regions in a variety of perceptual, cognitive, affective and behavioral domains. We hope that this current Research Topic provides a comprehensive review to understand roles of the subcortical brainstem-limbic regions in some forms of sensory-motor coupling, cognitive and affective functions.
    Keywords: R5-920 ; RC321-571 ; RC435-571 ; BF1-990 ; Q1-390 ; Subcortical visual pathway ; Saccades ; Amygdala ; Pulvinar ; Superior colliculus ; Limbic system ; Cognition ; Emotion ; Faces ; Reward and aversion ; bic Book Industry Communication::M Medicine
    Language: English
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  • 92
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    Academic Studies Press
    Publication Date: 2022-05-02
    Description: For more than two hundred years, the eighteenth-century polymath Mikhail Vasil’evich Lomonosov (1711–1765) has been glorified in Russian culture as the “father” of Russian science, literature, and, more generally, learning. This study traces the evolution of Lomonosov’s imposing stature in Russian thought from the middle of the eighteenth century to the closing years of the Soviet period. It reveals much about the attitudes toward the meaning and significance of science in Russian culture, as well as about the rise of a Russian national identity, of which Lomonosov became an outstanding symbol. Steven Usitalo argues that Lomonosov’s fame has surpassed any realistic association with the known details of his life; he is of interest primarily as a symbolic figure who fulfilled the tangible intellectual and emotional requirements that Russian pride demanded in a national myth.
    Keywords: History ; History ; Alexander Pushkin ; Alexander Radishchev ; Isaac Newton ; Leonhard Euler ; Mikhail Lomonosov ; Russia ; Russian Academy of Sciences ; Russians ; Saint Petersburg
    Language: English
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  • 93
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: In the highly competitive world of biomedical science, often the rush to publish and to be recognized as "first" with a new discovery, concept or method, is lost in the hurly-burly of the moment, as "the maddening crowd" moves on to the next "new thing". One of the great things about immunology today is that it has only become mature as a science within the last half-century, and especially within the past 35 years as a consequence of the revolution of molecular immunology, which has taken place only since 1980. Consequently, most of those who have contributed to our new understanding of how the immune system functions are still alive and well, and still contributing. Thus, "A Living History of Immunology" collates many stories from the investigators who actually performed the experiments that have established the frontiers of immunology. Accordingly, this volume combats "revisionist science", by those who want to alter history by telling the stories a different way than actually happened. In this regard, one of the good things about science vs. other disciplines is that we have the written record of what was done, when it was done and by whom. Even so, we do not have the complete story or narrative of how and why experiments were done, and what made the differences that led to success. This volume captures and chronicles some of these stories from the past fifty years in immunology.
    Keywords: R5-920 ; RC581-607 ; cytotoxic T lymphocytes (CTL) ; antibody ; Interleukins ; immunology history ; B cells ; Macrophages ; T cells ; Antibody Forming Cells (AFC) ; Thymus ; T cell receptor (TCR) ; bic Book Industry Communication::M Medicine
    Language: English
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  • 94
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    Bloomsbury Academic | Bloomsbury Academic
    Publication Date: 2024-04-02
    Description: Assembling an impressive cast of contributors, this volume employs liminality as a lens through which to study the social and cultural history of animals in the modern city. It includes a variety of case studies, such as the horse-human relationship in the towns of New Spain, hunting practices in 17th-century France, the birth of the zoo in Germany and the role of the stray dog in the Victorian city, demonstrating the interrelated nature of animal and human histories. This is a vital resource for scholars and students interested in animal studies, urban history and historical geography.
    Keywords: History ; Europe ; Western ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 95
    Publication Date: 2023-12-21
    Description: While HIV/AIDS is a global public heath challenge, its impact is arguably greatest in the Sub-Saharan Africa (SSA), where new infections account for approximately 66% of the total number of HIV-positive persons globally. In SSA, medical, social, and economic resources are limited, thus necessitating innovative approaches to disease prevention. One of the mechanisms of prevention that is most promising occurs through HIV disclosure to family members (e.g., adult sexual partners) generally, and to children in particular. Our emphasis in this eBook is on HIV disclosure to children because it has multiple benefits, including improved adherence to antiretroviral medication treatment and understanding at an early age of the impact of sexual activity on the spread of HIV. While there is a noticeable gap in research on HIV disclosure to younger children, some of the general reasons for non-disclosure include concerns about fear of adult partners leaving relationships, and that children are too young to comprehend the severity of the situation and may tell others outside the family. Thus, it is critical to better understand how the HIV disclosure process happens (or does not happen) within HIV-affected families, as well as the best practices on how to disclose. In this eBook, we present a combination of empirical research studies and critical literature reviews that investigate the reasons for and for not disclosing HIV status within HIV-affected families and provide evidence-based practices that could be adopted by healthcare professionals to help HIV-positive parents facilitate disclosure activities within these families. This information can also be used by researchers, practitioners, and stakeholders who are in a position to influence policies on effective HIV disclosure practices, guidelines, and programs.
    Keywords: R5-920 ; RA1-1270 ; HIVAIDS ; Resource-poor setting ; HIV disclosure ; Parental HIV status disclosure ; Sub-Saharan Africa (SSA) ; Child HIV status disclosure ; HIV disclosure process ; bic Book Industry Communication::M Medicine
    Language: English
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  • 96
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    Pluto Press | Pluto Press
    Publication Date: 2024-04-02
    Description: Inventing Africa is a critical account of narratives which have selectively interpreted and misinterpreted the continent's deep past. Writers have created alluring images of lost cities, vast prehistoric migrations and golden ages of past civilisations. Debates continue on the African origins of humankind, the contributions of ancient Egypt to the world and Africa's importance to global history. Images of 'Africa', simplifying a complex and diverse continent, have existed from ancient Mediterranean worlds, slave trading nations and colonial powers to today's political elites, ecotourists and aid-givers. Robin Derricourt draws on his background as publisher and practitioner in archaeology and history to explore the limits and the dangers of simplifications, arguing - as with Said's concept of 'Orientalism' - that ambitious ideas can delude or oppress as well as inform. Defending Africa against some of the grand narratives that have been imposed upon its peoples, Inventing Africa will spark new debates in the history of Africa and of archaeology.
    Keywords: History ; Africa ; General ; thema EDItEUR::N History and Archaeology::NH History::NHH African history
    Language: English
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  • 97
    Publication Date: 2023-12-21
    Description: Tratando de temas, como a cultura e a subjetividade, as questões éticas da atualidade, a qualidade de vida no mundo contemporâneo etc., O Clássico e o Novo é o fruto de trabalhos apresentados no 2o Congresso Brasileiro de Ciências Sociais em Saúde, e reúne uma gama dos mais qualificados profissionais que tratam de diferentes temas, intencionando uma perspectiva multidisciplinar. Partindo do pressuposto de que dentro da própria área das Ciências Sociais há um processo de fragmentação que vem exigindo cada vez mais novas interlocuções interdisciplinares, procura-se aqui estabelecer um diálogo profícuo entre este campo do saber e a área da saúde. Dessa forma, ao abordar questões relacionadas à área da saúde, este livro se constitui como leitura obrigatória para os profissionais de saúde coletiva, introduzindo diferentes e instigantes propostas de reflexão para a saúde na atualidade.
    Keywords: R5-920 ; Qualidade de vida ; Política de saúde ; Iniquidade na saúde ; Política social ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 98
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    transcript Verlag | transcript Verlag
    Publication Date: 2024-04-02
    Description: Margaret Mead und Gregory Bateson gehörten in den 1930er und 1940er Jahren zu den führenden Vertretern der Cultural Anthropology in den USA. Die Anthropologie bot ihnen nicht nur einen Schlüssel, um das Verhältnis von »culture« und »personality« besser zu verstehen, sondern diente ihnen ebenso als Werkzeug, um die Haltung der amerikanischen Bevölkerung mit Blick auf den Zweiten Weltkrieg abzustimmen und ihre Feinde zu bekämpfen. So glaubte das Wissenschaftlerpaar daran, dass nur durch Arbeit an der Kultur der Aufbau einer friedlichen Welt gelingen könne. Diesen Selbst- und Weltdeutungspraktiken spürt Thilo Neidhöfer am Beispiel ihrer Ehe nach.
    Keywords: Margaret Mead ; Gregory Bateson ; Anthropologie ; Kultur ; USA ; 20. Jahrhundert ; Wissenschaftsgeschichte ; Kulturgeschichte ; Wissenschaft ; Amerikanische Geschichte ; Geschichte des 20. Jahrhunderts ; Geschichtswissenschaft ; Anthropology ; Culture ; 20th Century ; History of Science ; Cultural History ; Science ; American History ; History of the 20th Century ; History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: German
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  • 99
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    Berghahn Books
    Publication Date: 2024-04-01
    Description: Drawing on a broad range of archival material from state and SED party sources as well as Stasi files and individual farm records along with some oral history interviews, this book provides a thorough investigation of the transformation of the rural sector from a range of perspectives. Focusing on the region of Bezirk Erfurt, the author examines on the one hand how East Germans responded to the end of private farming by resisting, manipulating but also participating in the new system of rural organization. However, he also shows how the regime sought via its representatives to implement its aims with a combination of compromise and material incentive as well as administrative pressure and other more draconian measures. The reader thus gains valuable insight into the processes by which the SED regime attained stability in the 1970s and yet was increasingly vulnerable to growing popular dissatisfaction and economic stagnation and decline in the 1980s, leading to its eventual collapse.
    Keywords: History ; GDR ; East Germany ; development ; modernization ; SED ; political economy ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPQ Later 20th century c 1950 to c 1999
    Language: English
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  • 100
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    SciELO Books - Editora FIOCRUZ
    Publication Date: 2023-12-21
    Description: Neste livro, a autora busca introduzir uma reflexão sobre as articulações entre o tema da violência e suas repercussões na saúde dos brasileiros, por meio da conceituação da violência no campo sociológico, da sua articulação com a saúde e de propostas de atuação. A discussão abrange aspectos históricos, culturais, sociológicos e econômicos, considerando que em suas relações a violência se apresenta ora como manifestação da dinâmica e da trajetória de uma sociedade, ora como fenômeno específico que se destaca e influencia essa mesma dinâmica social.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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