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  • History  (875)
  • thema EDItEUR::N History and Archaeology  (831)
  • R5-920  (734)
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  • Chemical Engineering
  • General Chemistry
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  • 2020-2024  (2,396)
  • 2021  (2,396)
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Keywords
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Year
  • 1
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    John Miles Foley's World of Oralities (2021)
    Arc Humanities Press
    Details
    Publication Date: 2024-03-27
    Description: This collection brings together newly commissioned and cutting-edge essays on oral text and tradition ranging from the ancient and medieval world to the present day by a leading group of European and North American oral theorists. Using a range of materials including the Bible, Greek epic, Beowulf, Old Norse and Old English riddles, and medieval music, the contributors collectively work to refine, challenge, and further advance contemporary Oral Theory, an interdisciplinary school of thought heavily influenced by John Miles Foley, whose work provides the jumping-off point for this volume. The book includes a useful introduction to the history of oral theory and Foley’s ground-breaking and influential work.
    Keywords: Oral tradition; orality; performance; composition; narrative; Old Norse; Folklore; Beowulf; Medieval Music; Scandinavian religion; Anglo-Saxon Literature ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval ; thema EDItEUR::D Biography, Literature and Literary studies::DB Ancient, classical and medieval texts ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRR Other religions and spiritual beliefs::QRRT Indigenous, ethnic and folk religions and spiritual beliefs::QRRT1 Indigenous religions, spiritual beliefs and mythologies of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTD Oral history ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFF Historical and comparative linguistics ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500 ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history
    Language: English
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  • 2
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    Inszenierte Moderne. Populäres Theater in Berlin und London, 1880-1930 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: Modern popular culture came to the world from the stage. Even before film and radio had established themselves, popular theater had developed into a commercial and boundary-crossing entertainment industry that reached a mass audience. Tobias Becker compares the theater landscapes of London and Berlin and points out the cultural exchanges that took place between these metropolises during the long turn of the century (1880&#82111930).
    Keywords: D204-475 ; media history ; German-British history ; theater history ; urban history ; history of popular culture ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 3
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    Im Steilhang (2021)
    Universitätsverlag Göttingen
    Details
    Publication Date: 2024-04-08
    Description: The „Flecken Adelebsen“ at the edge of the „Solling“ in southern Lower-Saxony looks back to 300 years of jewish history. In 19th century it was named “Little Jerusalem” because of the high number of jewish habitants. Today only the jewish graveyard has outlived. The aim of this documentation is to tap this “House of Living” as a new historical resource and do a part of an outstanding and necessary mourning work.
    Keywords: Lower Saxony ; Bremen ; History ; History of Jewry beyond Israel ; bic Book Industry Communication::H Humanities::HR Religion & beliefs ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRJ Judaism ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRJ Judaism
    Language: German
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  • 4
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    Provinz zwischen Reich und Republik. Politische Mentalitäten in Deutschland und Frankreich 1918-1933/36 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 5
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    Normatividades e instituciones eclesiásticas en el virreinato del Perú, siglos XVI–XIX (2021)
    Max Planck Institute for Legal History and Legal Theory
    Details
    Publication Date: 2024-03-23
    Description: Ecclesiastical institutions and actors were essential for the formation of normative orders in early modern Ibero-America. In a series of seminars, organised by the Max Planck Institute for European Legal History in Mexico City, Lima, Bogotá and São Paulo, scholars from different disciplines presented innovative studies on the history of religious normativity and its practices. Based upon the Lima colloquium, the present volume focuses on the viceroyalty of Peru (16th-19th centuries).
    Keywords: Ibero-American history (16th–19th centuries) ; viceroyalty of Peru ; derecho indiano ; canon law ; church history ; ecclesiastical legislation ; litigation in canon law ; religious orders ; diocesan administration ; royal patronage ; evangelization ; thema EDItEUR::1 Place qualifiers::1K The Americas::1KL Latin America – Mexico, Central America, South America::1KLS South America::1KLSR Peru ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAZ Legal history
    Language: Spanish
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  • 6
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    Electrospun and Electrosprayed Formulations for Drug Delivery (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
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    Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 8
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    An Aqueous Territory (2021)
    Duke University Press
    Details
    Publication Date: 2024-04-02
    Description: In 'An Aqueous Territory' Ernesto Bassi traces the configuration of a geographic space he calls the transimperial Greater Caribbean between 1760 and 1860. Focusing on the Caribbean coast of New Granada (present-day Colombia), Bassi shows that the region's residents did not live their lives bounded by geopolitical borders. Rather, the cross-border activities of sailors, traders, revolutionaries, indigenous peoples, and others reflected their perceptions of the Caribbean as a transimperial space where trade, information, and people circulated, both conforming to and in defiance of imperial regulations. Bassi demonstrates that the islands, continental coasts, and open waters of the transimperial Greater Caribbean constituted a space that was simultaneously Spanish, British, French, Dutch, Danish, Anglo-American, African, and indigenous.
    Keywords: History ; Colombia ; Haiti ; Jamaica ; Riohacha ; Santa Marta ; Spain ; United States ; Wayuu people ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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  • 9
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    Collapse of Memory - Memory of Collapse (2021)
    Böhlau
    Details
    Publication Date: 2024-04-04
    Description: The attraction of crises keeps going an entire sector of the media industry. Authors, painters, photographers and directors tell fascinating stories about the decline of empires and democracies as much as earthquakes and infectious diseases. Hereby, catastrophe and collapse evolve as a complex construct of experience, interpretation and emotion. The resulting narrative combines analyses of facts about the collapse with a retrospect evaluation, update and confirmation of these facts in the cultural memory of a given society. The random occurrence becomes a memorable event. The contributors of this volume have taken a narratological approach in examining collapse, disaster, catastrophe and how these in turn manifest themselves across different types of media.
    Keywords: History ; Social History ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English
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  • 10
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    Chinese Surplus (2021)
    Duke University Press
    Details
    Publication Date: 2022-05-02
    Description: In CHINESE SURPLUS Ari Heinrich dissects the figure of the medically or artistically commodified body in Chinese culture and popular science. Providing a history of how bodies have been thought and seen to mirror the nation, Heinrich charts the trajectory from an imperial idea of the body as a machine with interchangeable parts to current representations in which the parts are worth more than the whole and may be harvested at will--what he calls a diasporic form of the body. In seeing the body this way Heinrich makes clear his case for a new method he calls biopolitical aesthetics, one that uses the tools of literary and visual culture analysis to restore agency to aesthetics in the production of meaning in life during contemporary biopolitical times.
    Keywords: History ; Aesthetics ; China ; Hong Kong
    Language: English
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  • 11
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    Neuroimmune Interface in Health and Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
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  • 12
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    Japan at War and Peace (2021)
    ANU Press | ANU Press
    Details
    Publication Date: 2024-04-02
    Description: The question of how to maintain the continuity of diplomacy while developing democracy without military intervention is an old and new issue. The challenge can be described as a dilemma between democracy and diplomatic coherence. This dilemma is not unique to the twenty-first century; it has been a constant challenge to the development of democracy. In non-Western countries, democratisation originated in the nineteenth century and has had many successes and failures. After the Russo-Japanese War, political parties began to take power in Japan. The best embodiment of diplomacy in Japan's emerging democracy—the development of parliamentary democracy and mass-based democracy—is Shidehara Kijūrō (1872–1951), who served as foreign minister from 1924 to 1927 and from 1929 to 1931, and was prime minister from 1945 to 1946. As a diplomat from the Ministry of Foreign Affairs, Shidehara had long grappled with the issue of how to ensure diplomatic coherence in modern Japan, which was becoming increasingly democratic. Although Shidehara succeeded to some extent in promoting diplomacy in cooperation with the US and the UK under party politics, the rise of the military after the Manchurian Incident forced him to retire for a period. However, after the Pacific War, Shidehara became prime minister of the US-occupied Japan and attempted to restore cooperative diplomacy under party politics. Shidehara came to the conclusion that the way to achieve both democracy and diplomatic coherence was through nonpartisan diplomacy towards peace. This book examines the tension between diplomacy and democracy, focusing on Shidehara’s life and exploring modern Japan’s footsteps. Shidehara was undoubtedly one of Japan’s most important diplomatic figures.
    Keywords: constitution ; War ; diplomacy ; Prime Minister ; Japan ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPQ Later 20th century c 1950 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSD Diplomacy
    Language: English
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  • 13
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    Printing and Prophecy (2021)
    University of Michigan Press | University of Michigan Press
    Details
    Publication Date: 2024-04-02
    Description: "Printing and Prophecy: Prognostication and Media Change 1450-1550 examines prognostic traditions and late medieval prophetic texts in the first century of printing and their effect on the new medium of print. The many prophetic and prognostic works that followed Europe's earliest known printed book—not the Gutenberg Bible, but the Sibyl's Prophecy, printed by Gutenberg two years earlier and known today only from a single page—over the next century were perennial best sellers for many printers, and they provide the modern observer with a unique way to study the history and inner workings of the print medium. The very popularity of these works, often published as affordable booklets, raised fears of social unrest. Printers therefore had to meet customer demand while at the same time channeling readers' reactions along approved paths. Authors were packaged—and packaged themselves—in word and image to respond to the tension, while leading figures of early modern culture such as Paracelsus, Martin Luther, and Sebastian Brant used printed prophecies for their own purposes in a rapidly changing society. Based on a wide reading of many sources, Printing and Prophecy contributes to the study of early modern literature, including how print changed the relationship among authors, readers, and texts. The prophetic and astrological texts the book examines document changes in early modern society that are particularly relevant to German studies and are key texts for understanding the development of science, religion, and popular culture in the early modern period. By combining the methods of cultural studies and book history, this volume brings a new perspective to the study of Gutenberg and later printers."
    Keywords: History ; Astrology ; Latin ; Lichtenberger ; Practica (astrology) ; Prophecy ; Woodcut ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 14
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    Contro frate Bernardino da Siena. Processi al maestro Amedeo Landi (Milano 1437-1447) (2021)
    Milano University Press
    Details
    Publication Date: 2024-04-01
    Description: The volume Contro Bernardino. Processi al maestro Amedeo Landi is the result of the discovery of unpublished documentation on the trials - only partly known - against the abacus master Amedeo Landi, who taught the Milanese merchants at the Broletto. This is an exceptional case not only because only one witness to the activity of the Milanese inquisitorial court in the Middle Ages (whose documentation has been entirely lost) was known until now, but also because of the role of the ecclesiastical court and its officials. The wealth of information and themes has prompted a team effort by the professors of the Department of Historical Studies to clarify the many aspects (political, religious, economic, documentary) of an event that shows the vitality of 15th-century Milan, in which the protagonist, the teacher Amedeo Landi, in an attempt to protect his students, clashes with the most important preacher of his time, Brother Bernardino of Siena, whose canonisation process is temporarily blocked precisely to shed light on the Milanese episode.
    Description: Published
    Description: Il volume Contro Bernardino. Processi al maestro Amedeo Landi nasce dal ritrovamento di documentazione inedita riguardo ai processi – solo in parte noti – contro il maestro d’abaco Amedeo Landi che insegnava ai mercanti milanesi presso il Broletto. Si tratta di un caso eccezionale non solo perché finora si conosceva un solo testimone dell’attività del tribunale inquisitoriale milanese nel medioevo (la cui documentazione è andata interamente perduta), ma anche per il ruolo del tribunale ecclesiastico e dei suoi funzionari. La ricchezza delle informazioni e dei temi ha suggerito un lavoro d’équipe dei docenti del Dipartimento di studi storici per chiarire i molteplici aspetti (politici, religiosi, economici, documentari) di una vicenda che mostra la vitalità della Milano quattrocentesca, in cui il protagonista, il maestro Amedeo Landi, nel tentativo di tutelare i suoi studenti si scontra con il più importante predicatore del suo tempo, frate Bernardino da Siena, il cui processo di canonizzazione viene momentaneamente bloccato proprio per fare luce sull’episodio milanese.
    Keywords: eresia ; mercanti ; Bernardino da Siena ; Amedeo Landi ; Milano medievale ; inquisizione ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: Italian
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  • 15
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    Recursos Críticos: história da cooperação técnica Opas-Brasil em recursos humanos para a saúde (1975-1988) (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Um livro valioso, que analisa com clareza o papel fundamental dos recursos humanos para a saúde e o desenvolvimento, bem como o contexto e o impacto da reforma sanitária e a relação entre as iniciativas internacionais, nacionais e locais em prol da mudança dos serviços de saúde. Além de examinar os antecedentes e os principais atores da área de recursos humanos e explicar com detalhes as negociações que visavam transformar em prioridade nacional a formação de recursos humanos e a distribuição dos trabalhadores de saúde no território, Recursos Críticos está apoiado em uma sólida pesquisa bibliográfica, testemunhos fascinantes e análise original, que fazem da obra uma contribuição significativa no campo da memória da saúde pública e uma ferramenta indicativa de perspectivas de futuro para trabalhadores na área da saúde. É uma pesquisa histórica de grande qualidade, voltada para a análise da cooperação Opas-Brasil, e um incentivo à realização de novos estudos sobre as interfaces entre a atuação de agências internacionais e os interesses nacionais, partindo do conceito de arenas ou espaços de negociação.
    Keywords: R5-920 ; Brasil ; Recursos humanos em saúde ; Planos e programas de saúde ; Cooperação técnica ; Organização Pan-Americana da Saúde ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 16
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    Identitaetsbildung und Partizipation im 19. und 20. Jahrhundert (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-04
    Description: Gesellschaften mit starker Einwanderung kennzeichnen vielfältige Formen von Identitätsbildung und das Ringen um politische und zivilgesellschaftliche Partizipation. Dies gilt in besonderer Weise für Luxemburg im 19. und 20. Jahrhundert. Hier entstand in einem Kleinstaat eine der jüngeren Nationen Europas und zugleich eine besonders offene, plurikulturelle Einwanderungsgesellschaft. Ziel dieses Bandes ist es, die Entstehung dieser Mehr-Kulturen-Gesellschaft im europäischen Zusammenhang zu verstehen. Die einzelnen Beiträge analysieren mit Hilfe unterschiedlicher sozial- und kulturwissenschaftlicher Annäherungen exemplarische Konfliktlinien der Identitätsbildung und des Kampfes um Partizipation.
    Keywords: European history ; Biography: general ; Language teaching and learning ; History ; Social and cultural history ; General and world history ; Literature: history and criticism ; Literary studies: ancient, classical and medieval ; Literary theory ; Philosophy ; Politics and government ; Civics and citizenship ; Political science and theory ; Political control and freedoms ; Anthropology ; Social and cultural anthropology ; Ethnic studies ; Gender studies: women and girls ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: German
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  • 17
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    Inhibiting PARP as a Strategic Target in Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 18
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    International Perspectives on Health and Safety Among Dairy Workers Challenges, Solutions and the Future (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 19
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    From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders；celiac disease；gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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    Akten zur Auswärtigen Politik der Bundesrepublik Deutschland 1977 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Microglia in Health and Disease: A Unique Immune Cell Population (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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    Drifting Apart of Transatlantic Security (2021)
    Logos Verlag Berlin | Logos Verlag Berlin
    Details
    Publication Date: 2024-04-04
    Description: For the first time, this book examines the comparative impact of the Obama administration on the NATO and defense policies of European allies. Germany, Poland and Turkey serve as case studies to evaluate American policies vis-à-vis NATO Europe. All three are representative for the Alliance in various ways. Thus, the results of this book offer an outlook for NATO Europe and the Alliance as a whole. Despite the fact that all three countries are highly dependent on American security guarantees in theory and practice, the results of this study reveal different national responses. Indeed, the book demonstrates multi-, bi-, and unilateralization attempts in reaction to US engagement in and vis-à-vis NATO Europe. Hence, a better understanding of current developments within the Alliance as well as the basis for the future debate about the transatlantic organisation are provided. Aylin Matlé works for the Konrad-Adenauer-Stiftung e.V.; most recently, she worked for the foundation's Israel office in Jerusalem. Previously, Aylin Matlé was a research associate at the chair of international relations and European politics at the Martin-Luther-Universität Halle-Wittenberg.
    Keywords: History ; Military ; Political Science ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    HLA-G-mediated Immune Tolerance: Past and New Outlooks (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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    The Jesuit Order as a Synagogue of Jews  (2021)
    Brill | Brill
    Details
    Publication Date: 2024-04-01
    Description: In The Jesuit Order as a Synagogue of Jews the author explains how Christians with Jewish ancestry went within less than forty years from having a leading role in the foundation and development of the Society of Jesus to being prohibited from membership in it. Readership: All those interested in converso and Jesuit history, the history of Catholicism, the history of late medieval and early modern Iberia and Italy, as well as Spanish literature historians, historians of law, and theologians.
    Keywords: History ; Jewish History & Culture ; Converso ; Ignatius of Loyola ; Rome ; Society of Jesus ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    St Peter's, Barton-upon-Humber, Lincolnshire (2021)
    Historic England | Historic England
    Details
    Publication Date: 2024-03-23
    Description: St Peter's, Barton-upon-Humber, is a redundant medieval church in the care of English Heritage. As a result of a major program of research carried out between 1978 and 2007, it is now the most intensively studied parish church in the UK. Excavations between 1978 and 1984 investigated most of the interior of the building, as well as a swathe of churchyard around its exterior. At the same time, a stone-by-stone record and detailed archaeological study of the fabric and furnishings of the church was undertaken, continuing down to 2007. The twin aims of the project were to understand the architectural history and setting of this complex, multi-period building (Volume 1, Parts 1 and 2) and to recover a substantial sample of the population for palaeopathological study (Volume 2). An extensive program of historical and topographical research also took place in order to set the archaeological evidence firmly in context.
    Keywords: Architecture ; History ; History ; Europe ; Medieval ; History ; Europe ; Great Britain ; thema EDItEUR::A The Arts::AM Architecture::AMX History of architecture ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    European Monarchies from 1814 to 1906. A Century of Restorations (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: The year 2014 saw the 200th anniversary of Napoleon's downfall - and the restauration of the French monarchy under the house of Bourbon. With this as a starting point, Volker Sellin shows how the European monarchies restored and prolonged their reigns by giving their countries constitutions. This new angle results in an astonishing history of the 19th century in Europe from Spain to Russia.
    Keywords: D204-475 ; political legitimacy ; legal history ; constitutions ; Restauration ; monarchies ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    La ciudad de los monos Roberto Brenes Mesén, los católicos heredianos y el conflicto cultural de 1907 en Costa Rica (2021)
    Editorial Universidad Nacional (EUNA)
    Details
    Publication Date: 2024-04-01
    Description: In 1907, the city of Heredia became the epicenter of the most important religious conflict experienced by Costa Rica in the 20th century. A complaint that the theory of evolution was being taught in the Lyceum (i.e. secondary school) of that city, triggered an increasingly intense confrontation between the Catholic parishioners and the circle of young radical intellectuals articulating around the writer and educator Roberto Brenes Mesén. In the course of this process, Costa Rican society, to the alarm of the government of Cleto González Víquez, was the scene of popular mobilizations in defense of the faith, excommunications and burning of impious texts, while Catholic morality was systematically questioned based on sexual abuse attributed to priests. For a moment, it seemed that the country had gone back in time, and that the ghosts of 1884 were present.
    Keywords: Heredia (Costa Rica) – History – 1907 ; Catholic Church – Heredia (Costa Rica) ; Brenes Mesén, Roberto, 1874-1947 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: Spanish
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    Sobreviure a les presons de Franco: Testimoni epistolar de 1939 a 1943 (2021)
    Publicacions Universitat Rovira i Virgili
    Details
    Publication Date: 2024-04-01
    Description: Aquest estudi sobre la presó franquista de postguerra es basa en les duescentes quaranta cartes que Daniel Vilaró Rius va escriure a la seva família entre juliol del 1939 i agost del 1943 des de tres presons i, per tant, presenta el règim penitenciari viscut des de dins. En aquestes cartes trobem en primera persona l’impacte psicològic de la derrota, dels judicis sumaríssims i de l’empresonament, la por i la incertesa de cada dia, la penúria, la privació emocional de l’allunyament de la família, la frustració de no poder exercir cap rol familiar. Alhora, la voluntat de sobreviure física i moralment, que va ser una voluntat política, i els mecanismes i estratègies que van fer que molts ho aconseguissin, des de l’ajut de fora i la solidaritat a dins, fins a la capacitat de cadascú per mantenir alguna il·lusió i la fe en el futur.
    Keywords: D204-475 ; Guerra Civil espanyola ; presons ; franquisme ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: Catalan
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    Mechanical Loading and Bone (2021)
    Frontiers Media SA
    Details
    Publication Date: 2022-01-31
    Description: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Keywords: RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
    Language: English
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    Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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    Ricerche sull'organizzazione del territorio nella Liguria medievale (2021)
    Firenze University Press
    Details
    Publication Date: 2024-04-01
    Description: The organisation of the territory is the outcome of strategies of varying scope, in which a number of agents interact to shape out the areas of operation. The Liguria reality is probed here through four different situations - separated in chronological terms but sharing the poor visibility and limited efficacy of the fortified settlements. These focus on Genoa, both in the definition of its hinterland between the tenth and the eleventh centuries, and in establishing the bulwarks of coastal territorial expansion in the twelfth; the powerful groups of feudal lords who remoulded the rural settlement layout in the thirteenth century; finally, a village of the hinterland explored right through to the modern age.
    Keywords: D111-203 ; Comuni medievali ; Open Access ; Storia ; Societ&agrave ; Liguria ; Signorie ; Medioevo ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
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    Transmucosal Absorption Enhancers in the Drug Delivery Field (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
    Language: English
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    Between State and Church (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-01
    Description: The different theoretical notions and practices of the relations between the state and religious communities in early modern Europe constitute one of the most interesting problems in historiography. Moving away from a simple «toleration» versus «non-toleration» dichotomy, the author sets out to analyse the inter-confessional relations in selected European territories in a «longue duree» perspective, between Reformation and Enlightenment. Outlining the relations between the state and the different Churches (confessions) in the Polish-Lithuanian Commonwealth, the Holy Roman Empire of Germany, and the Northern Netherlands serves to highlight the specificity of Northern Netherlands serves to highlight the specificity of «free» (non-absolutist) composite states, where the particularly complex process of defining the raison d’etat determined the level of religious toleration that was politically feasible and socially acceptable.
    Keywords: Church ; Church-state relations ; Confessional ; Denominational relations ; Enlightenment ; Germany ; Humanist and political theory ; Kriegseisen ; Lithuania ; Netherlands ; Poland ; Protestant and Catholic reformers ; Reform ; Reformation ; Relations ; State ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    American Sociology and Holocaust Studies (2021)
    Academic Studies Press | Academic Studies Press
    Details
    Publication Date: 2024-03-27
    Description: Filled with new elements that challenge common scholarly theses, this book acquaints the reader with the “Jewish problem” of sociology and provides what this academic discipline urgently needs: a one-volume history of the Sociology of the Holocaust. The story of why and how sociologists as well as the schools of sociological thought came to confront the Holocaust has never been entirely told. The volume offers original insights on the nature of American sociology with implications for the post-Holocaust sociology development.
    Keywords: Fiction ; Action & Adventure ; History ; Holocaust ; thema EDItEUR::F Fiction and Related items::FJ Adventure / action fiction ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTZ Genocide and ethnic cleansing::NHTZ1 The Holocaust ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR7 Second World War ; thema EDItEUR::1 Place qualifiers::1D Europe ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBL c 1940 to c 1949
    Language: English
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    Noble conceptions of politics in eighteenth-century Sweden (ca 1740–1790) (2021)
    Finnish Literature Society / SKS
    Details
    Publication Date: 2024-04-01
    Description: "Noble conceptions of politics in eighteenth-century Sweden (ca 1740–1790) is a study of how the Swedish nobility articulated its political ideals, self-images and loyalties during the Age of Liberty and under the rule of Gustav III. This book takes a close look at the aristocracy’s understanding of a free constitution and at the nobility’s complex relationship with the monarchy. Central themes are the old notion of mixed government, classical republican conceptions of liberty and patriotism, as well as noble thoughts on the rights and duties of the citizen, including the right to rebellion against an unrighteous ruler. The study is a conceptual analysis of public and private political statements made by members of the nobility, such as Diet speeches and personal correspondence. The book contributes to the large body of research on estate-based identities and the transformation of political language in the second half of the eighteenth century by connecting Swedish political ideals and concepts to their European context."
    Keywords: upper class ; identity (mental qualities) ; political elite ; ideals ; systems of government ; nobility ; Age of Liberty ; Autocracy ; Finland ; Gustav III of Sweden ; Stockholm ; Sweden ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Beyond Exceptionalism (2021)
    De Gruyter | De Gruyter Oldenbourg
    Details
    Publication Date: 2024-04-02
    Description: While the economic involvement of early modern Germany in slavery and the slave trade is increasingly receiving attention, the direct participation of Germans in human trafficking remains a blind spot in historiography. This edited volume focuses on practices of enslavement taking place within German territories in the early modern period as well as on the people of African, Asian, and Native American descent caught up in them.
    Keywords: Slavery ; Germany ; Atlantic history ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTQ Colonialism and imperialism ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTR National liberation and independence ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTS Slavery and abolition of slavery
    Language: English
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    Regieren: Die Geschichte einer Zumutung (2021)
    transcript Verlag
    Details
    Publication Date: 2024-03-29
    Description: Szenen einer missvergnügten Ehe - dieses bürgerliche Trauerspiel wird derzeit auf den politischen Bühnen westlicher Demokratien gegeben. Es führt vor, wie weit sich Regierende und Regierte auseinander gelebt haben. Von heute auf morgen passiert so etwas nicht. Der Band lässt die wechselvolle Geschichte des Regierens Revue passieren und zeigt, wie angespannt das Verhältnis seit jeher gewesen ist. Dass Kanzler Könige und Bürger Bauern abgelöst haben, hat daran nichts geändert. Andererseits hält diese Mesalliance erstaunlich viel aus - selbst nach blutigen Konflikten arrangiert man sich wieder und findet ein neues Gleichgewicht der Frustration. Die Hoffnung, es gehe trotz allem stetig aufwärts, muss derzeit wieder einmal begraben werden.
    Keywords: Political Science ; Governance ; Resistance ; Souvereignity ; Representation ; Repression ; Loyalty ; Disenchantment with Politics ; Neoliberalism ; Politics ; Political Theory ; Democracy ; History ; Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: German
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    Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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    Textiles in Ancient Mediterranean Iconography (2021)
    Oxbow Books | Oxbow Books
    Details
    Publication Date: 2024-04-02
    Description: This volume provides an ambitious synopsis of the complex, colourful world of textiles in ancient Mediterranean iconography. A wealth of information on ancient textiles is available from depictions such as sculpture, vase painting, figurines, reliefs and mosaics. Commonly represented in clothing, textiles are also present in furnishings and through the processes of textile production. The challenge for anyone analysing ancient iconography is determining how we interpret what we see. As preserved textiles rarely survive in comparable forms, we must consider the extent to which representations of textiles reflect reality, and critically evaluate the sources. Images are not simple replicas or photographs of reality. Instead, iconography draws on select elements from the surrounding world that were recognisable to the ancient audience, and reveal the perceptions, ideologies, and ideas of the society in which they were produced. Through examining the durable evidence, this anthology reveals the ephemeral world of textiles and their integral role in the daily life, cult and economy of the ancient Mediterranean.
    Keywords: History ; Ancient ; Rome ; History ; Ancient ; Design ; Textile & Costume ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::A The Arts::AK Design, Industrial and commercial arts, illustration::AKT Fashion and textile design
    Language: English
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    How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
    Language: English
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    Auf die Tour!: Jüdinnen und Juden in Singspielhalle, Varieté und Kabarett – Habsburgermonarchie bis Amerika (2021)
    Böhlau
    Details
    Publication Date: 2024-04-01
    Description: In the monography Auf die Tour, I analyze the participation of Jews in popular culture in Vienna, Budapest and New York. I argue that entertainment in vaudevilles was shaped between the perception of difference and similarity, between human trafficking, covert prostitution, anti-Semitism and nationalism. Ultimately, my research shows how a space for Jewish-non-Jewish people was created in the coinciding of the mass migration movement and the emerging mass culture between the Habsburg Monarchy and the United States.
    Description: Auf die Tour berichtet von der Teilhabe von Jüdinnen und Juden an der populären Kultur in Wien, Budapest und New York. Zwischen Differenzwahrnehmungen und Ähnlichkeitsdenken, zwischen Menschenhandel, verdeckter Prostitution, Antisemitismus und Nationalismus gestaltete sich Unterhaltung in Varietés. Meine Forschung zeigt, wie sich ein Raum für jüdisch-nichtjüdische Begegnungen in der Massenmigrationsbewegung und der entstehenden Massenkultur zwischen der Habsburgermonarchie und den Vereinigten Staaten ergab.
    Keywords: Jews, fin-de-siècle, Jewish and non-Jewish Relations, cultural exchange, Habsburg Empire, popular entertainment, Vienna, Budapest, New York ; ÖFOS 2012, Regional history ; ÖFOS 2012, Cultural studies ; ÖFOS 2012, Gender studies ; ÖFOS 2012, Global history ; Jüdinnen und Juden, jüdisch-nichtjüdische Beziehungen, kultureller Austausch, Jahrhundertwende, Habsburgermonarchie, Populärkultur, Wien, Budapest, New York ; ÖFOS 2012, Regionalgeschichte ; ÖFOS 2012, Kulturwissenschaft ; ÖFOS 2012, Gender Studies ; ÖFOS 2012, Globalgeschichte ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSR Social groups: religious groups and communities ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PG Relating to religious groups::5PGJ Relating to Jewish people and groups
    Language: German
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    Wirtschaftserfolg zwischen Zufall und Innovativität (2021)
    Franz Steiner Verlag
    Details
    Publication Date: 2024-04-04
    Description: Wie erklärt sich Wirtschaftserfolg? Dieser Frage geht Beat Fumasoli mit Blick auf die gewerbliche Exportwirtschaft von oberdeutschen Städten im Spätmittelalter nach. Der oberdeutsche Wirtschaftsraum gewann besonders ab dem 14. Jahrhundert stark an Bedeutung – seine zentrale Lage in der Mitte Europas ermöglichte einen weit ausgreifenden Exporthandel in alle Himmelsrichtungen. Mit Augsburg, Basel, Freiburg im Üechtland, Nördlingen, Nürnberg, Passau, Ravensburg, Regensburg, Schwäbisch Gmünd, Speyer, St. Gallen und Wangen im Allgäu betrachtet Fumasoli gut ein Fünftel der oberdeutschen Städte mit Exportgewerbe und unterzieht sie einem systematischen Vergleich. Dieser erstreckt sich auf alle potenziell relevanten Einflussfaktoren des exportgewerblichen Wirtschaftserfolgs: von den Rahmenbedingungen für Produktion und Handel bis hin zu den Organisations- und Absatzstrategien der Wirtschaftsakteure und ihrer Kooperation in einem hochgradig arbeitsteiligen Gesamtsystem.
    Keywords: History ; Mittelalter ; Middle Ages ; Medieval History ; Wirtschafts- und Sozialgeschichte ; Stadtgeschichte ; Urban History ; Innovation ; Handelsgeschichte ; History ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: German
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    Der Berliner „jüdische Salon“ um 1800 (2021)
    De Gruyter
    Details
    Publication Date: 2024-03-29
    Description: Anhand neuer Quellen werden die Berliner 'jüdischen Salons' um 1800 als ebenso lebendiges wie fragiles kommunikatives Netz präsentiert. Der Querschnitt durch die Salongesellschaft des Beispieljahrs 1794/95 beleuchtet eine Geselligkeitskultur, in der verschiedene Orte zu Salons wurden. Längsschnitte durch jahrzehntelang geführte Korrespondenzen erlauben die Frage nach Wechselwirkungen zwischen Salons und zeitgenössischen Emanzipationsdiskursen.
    Keywords: Jewish Studies ; Europe ; Germany ; HIS022000 ; History ; Jewish ; LIT004210 ; SOC049000 ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSR Social groups: religious groups and communities ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PG Relating to religious groups::5PGJ Relating to Jewish people and groups
    Language: English
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    Movable Inn. The Rural Jewish Population of Minsk Guberniya in 1793-1914 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: The book presents the results of a systematic survey, the first of its kind, on the rural Jews in the Minsk Guberniya, from its establishment as a major administrative unit within the Russian Empire in 1793, to the outbreak of the First World War in 1914.
    Keywords: D204-475 ; DJK1-77 ; family structure ; Jews ; demography ; culture ; landlords ; Belarus ; genealogy ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Recent advances in γδ T cell biology: New ligands, new functions, and new translational perspectives (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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    Making Muslim Women European (2021)
    Central European University Press
    Details
    Publication Date: 2024-04-04
    Description: This social, cultural, and political history of Slavic Muslim women of the Yugoslav region in the first decades of the post-Ottoman era is the first to provide a comprehensive overview of the issues confronting these women. It is based on a study of voluntary associations (philanthropic, cultural, Islamic-traditionalist, and feminist) of the period. It is broadly held that Muslim women were silent and relegated to a purely private space until 1945, when the communist state “unveiled” and “liberated” them from the top down.  After systematic archival research in Bosnia, Croatia, Serbia, and Austria, Fabio Giomi challenges this view by showing:  How different sectors of the Yugoslav elite through association publications, imagined the role of Muslim women in post-Ottoman times, and how Muslim women took part in the construction or the contestation of these narratives.  How associa­tions employed different means in order to forge a generation of “New Muslim Women” able to cope with the post-Ottoman political and social circumstances.  And how Muslim women used the tools provided by the associations in order to pursue their own projects, aims and agendas.  The insights are relevant for today’s challenges facing Muslim women in Europe. The text is illustrated with exceptional photographs.
    Keywords: History ; Women ; History ; Europe ; Eastern ; Social Science ; Gender Studies ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups
    Language: English
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    Maintaining Peace and Interstate Stability in Archaic and Classical Greece (2021)
    Vandenhoeck & Ruprecht
    Details
    Publication Date: 2024-04-02
    Description: This volume presents the contributions to a symposium held on May 9th, 2009 at the Humanities Center at Harvard University that focused on the question of how peace and interstate stability were established and maintained in archaic and classical Greece. In this context, different perspectives and approaches, ranging from pragmatic political goals and the definition and interpretation of key terms such as eirene to the underlying norms and their relevance for the realpolitik, were discussed. The articles in this volume shed new light on the various political instruments that the Greeks developed and employed to avoid war and to keep and organize peace. They focus on the analysis of commonly accepted terms that provided the basis for a settlement between conflicting parties and the analysis of various political strategies, including one-time arrangements to limit military conflicts, diplomatic efforts, legally binding agreements and more comprehensive concepts of interstate stability.
    Keywords: History ; Ancient ; General ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history
    Language: English
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    Ginseng and Borderland (2021)
    University of California Press | University of California Press
    Details
    Publication Date: 2024-04-01
    Description: Ginseng and Borderland explores the territorial boundaries and political relations between Qing China and Chosŏn Korea during the period from the early seventeenth to the late nineteenth centuries. By examining a unique body of materials written in Chinese, Manchu, and Korean, and building on recent studies in New Qing History, Seonmin Kim adds new perspectives to current understandings of the remarkable transformation of the Manchu Qing dynasty (1636–1912) from a tribal state to a universal empire. This book discusses early Manchu history and explores the Qing Empire’s policy of controlling Manchuria and Chosŏn Korea. Kim also contributes to the Korean history of the Chosŏn dynasty (1392–1910) by challenging conventional accounts that embrace a China-centered interpretation of the tributary relationship between the two polities, stressing instead the agency of Chosŏn Korea in the formation of the Qing Empire. This study demonstrates how Koreans interpreted and employed this relationship in order to preserve the boundary—and peace—with the suzerain power. By focusing on the historical significance of the China-Korea boundary, this book defines the nature of the Qing Empire through the dynamics of contacts and conflicts under both the cultural and material frameworks of its tributary relationship with Chosŏn Korea.
    Keywords: History ; General ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Alfred Dreyfus (2021)
    Academic Studies Press | Academic Studies Press
    Details
    Publication Date: 2024-04-04
    Description: This groundbreaking book focuses on Alfred Dreyfus the man, with emphasis placed on his own writings, including his recently published prison workbooks and his letters to his wife Lucie. Through close reading of these documents, a much more sensitive, intellectual, and Jewish man is revealed than was previously suspected. He and Lucie, through their family connections and mutual loyalty, were interested in and supported the artistic, scientific, philosophical and historical movements that formed their Parisian milieu. But as an Alsatian Jew, Alfred was also critical of many aspects of technological and ideological developments, making his mentality one of skepticism as well as idealism.
    Keywords: History ; Jewish ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English
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    Església i franquisme: De la col·laboració amb el franquisme al seu combat (2021)
    Publicacions Universitat Rovira i Virgili
    Details
    Publication Date: 2024-04-01
    Description: Este libro quiere aportar conocimiento y arrojar luz sobre los hechos transcurridos durante la Guerra Civil y tras los años de dictadura, en relación al papel que jugó la Iglesia en esta época histórica. Los lectores verán enseguida cómo las relaciones entre religión y Estado pasaron por diferentes vicisitudes y etapas, y que en puridad deberíamos hablar del papel que jugaron las Iglesias (en plural) o si se prefiere de los papeles (en plural) que jugó la Iglesia. En los largos cuarenta años de la dictadura, la Iglesia sufrió importantes transformaciones, al compás de las que se experimentaban en el tejido social. Los lectores las encontrarán en estas páginas y comprobarán, una vez más, que la historia no se escribe de forma lineal.
    Keywords: D204-475 ; Guerra Civil española ; franquismo ; Iglesia ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: Catalan , Spanish
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    The City by the Pool (2021)
    Historic England | Historic England
    Details
    Publication Date: 2024-04-04
    Description: This volume offers a new and up-to-date synthesis of Lincoln's long history as a major city and regional capital, from prehistory to 1945. The 'City by the Pool' was a major religious centre long before the Roman invasion and from bronze-age shamans to early Baptists people have always been attracted here for spiritual as well as mundane purposes. The authors argue for the presence of a major ritual causeway of the late Bronze and Iron Age and outline the extent to which ritual monuments also contributed to the character of Roman Lincoln. This book is based on more than a hundred publicly-funded excavations and building surveys undertaken between 1945 and 2000. It surveys all aspects of city life, from housing and fortifications to the water supply and rubbish disposal. It includes a CD Rom with a Geographic Information System (GIS) and a relational data-base known as LARA (the Lincoln Archaeological Research Assessment).
    Keywords: Social Science ; Archaeology ; History ; Europe ; Great Britain ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Akten zur Auswärtigen Politik der Bundesrepublik Deutschland 1974 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    La relación médico-paciente (2021)
    Publicacions i Edicions de la Universitat de Barcelona
    Details
    Publication Date: 2023-12-21
    Description: La relación médico-paciente está sometida a varias presiones. La financiación de la asistencia sanitaria puede determinar tanto la percepción colectiva del acceso a los recursos sociales (prestaciones económicas, centros de atención especializada, ayudas a domicilio, entre otros) como la prescripción de medicamentos y de pruebas complementarias. Además de las prioridades del financiador o de los beneficiarios de los resultados económicos, las campañas publicitarias influyen también en el criterio del paciente, al que la industria farmacéutica halaga convenciéndolo de que posee conocimientos de medicina y de que es un consumidor con el poder de escoger, cuando en realidad decide porque tiene los medios económicos para pagar su elección. En este libro se analizan las razones que empujan a los profesionales de la sanidad hacia una parcialidad interesada, así como las consecuencias éticas que ello tiene sobre el individuo y sobre la eficiencia del sistema sanitario.
    Keywords: R5-920 ; RA1-1270 ; BJ1-1725 ; Relacions metge-pacient ; Medicina ; Dret ; bic Book Industry Communication::M Medicine
    Language: Spanish
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    Inventar der Offenen Befehle der Sowjetischen Militaeradministration des Landes Brandenburg (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-01
    Description: Die Publikation ist ein Gemeinschaftsprojekt des Lehrstuhls Geschichte der Militäruniversität des Verteidigungsministeriums der Russischen Föderation (Moskau), des Zentrums für Zeitgeschichte von Bildung und Wissenschaft der Universität Hannover und des Brandenburgischen Landeshauptarchivs (Potsdam). Erstmals wird hier ein Überblick über die im Staatsarchiv der Russischen Föderation in Moskau vorhandene Offene Serie der Befehle der Sowjetischen Militäradministration des Landes Brandenburg – SMAB – gegeben. Einleitend erfolgen quellenkritische und institutionsgeschichtliche Untersuchungen zur Thematik. Den Hauptteil bildet das Inventar der von der Verwaltung der SMAB zwischen 1945 und 1949 erlassenen Offenen Befehle. Auf Interesse dürfte ebenfalls die Übersicht über die von der SMAB erlassenen «Anweisungen» stoßen.
    Keywords: Befehle ; Brandenburg ; Brandenburgisches ; Föderation ; Inventar ; Landes ; Landeshauptarchiv ; Militäradministration ; Offene ; Offenen ; Russischen ; Sowjetischen ; Staatsarchiv ; Überlieferung ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MR 21st century, c 2000 to c 2100 ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPP Public administration
    Language: German
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    Global health issues of aflatoxins in food and agriculture: Challenges and opportunities (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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    Women’s Activism and "Second Wave" Feminism (2021)
    Bloomsbury Academic
    Details
    Publication Date: 2023-11-16
    Description: Women’s Activism and "Second Wave" Feminism situates late 20th century feminisms within a global framework of women’s activism. Its chapters, written by leading international scholars, demonstrate how issues of heterogeneity, transnationalism, and intersectionality have transformed understandings of historical feminism. It is no longer possible to imagine that feminism has ever fostered an unproblematic sisterhood among women blind to race, ethnicity, class, sexuality, nationality and citizenship status. The chapters in this collection modify the "wave" metaphor in some cases and in others re-periodize it. By studying individual movements, they collectively address several themes that advance our understandings of the history of feminism, such as the rejection of "hegemonic" feminism by marginalized feminist groups, transnational linkages among women’s organizations, transnational flows of ideas and transnational migration.
    Keywords: History ; History of Feminism ; Women's activism ; Transnationalism ; Intersectionality ; Hisotrical Feminism ; Feminist Waves ; Gender Studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFK Feminism & feminist theory
    Language: English
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    Marine Compounds and Cancer (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
    Language: English
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    Diplomatie mit Gefühl. Vertrauen, Misstrauen und die Außenpolitik der Bundesrepublik Deutschland (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: Following the Second World War, Germany no longer enjoyed the trust of other nations. What did West Germany do to rebuild confidence? What was the role of trust, mistrust, and supervision during the East-West conflict as West Germany was integrated into the Western alliance, and how did they affect international relations between the two blocs? This study examines personal ties, rhetorical strategies, and institutional connections.
    Keywords: D204-475 ; JZ2-6530 ; DD1-905 ; Foreign policy East-Western conflict Germany ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Epigenetics of B Cells and Antibody Responses (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
    Language: English
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    Women and Power at the French Court, 1483-1563 (2021)
    Amsterdam University Press | Pallas Publications
    Details
    Publication Date: 2024-04-01
    Description: Women and Power at the French Court, 1483—1563 explores the ways in which a range of women “ as consorts, regents, mistresses, factional power players, attendants at court, or as objects of courtly patronage “ wielded power in order to advance individual, familial, and factional agendas at the early sixteenth-century French court. Spring-boarding from the burgeoning scholarship of gender, the political, and power in early modern Europe, the collection provides a perspective from the French court, from the reigns of Charles VIII to Henri II, a time when the French court was a renowned center of culture and at which women played important roles. Crossdisciplinary in its perspectives, these essays by historians, art and literary scholars investigate the dynamic operations of gendered power in political acts, recognized status as queens and regents, ritualized behaviors such as gift-giving, educational coteries, and through social networking, literary and artistic patronage, female authorship, and epistolary strategies.
    Keywords: History ; women ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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    Saúde, trabalho e formação profissional (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Reúne textos de especialistas das áreas de Saúde e de Educação com longa, competente e comprometida atuação na luta por mudanças sociais, preocupados com um (con)viver humano mais solidário. A obra mostra ser possível a constituição de serviços de saúde com profissionais sensíveis e preparados para atuar em tempos de novas exigências técnicas e de capacitação profissional. Por instigar a (re)pensar o aperfeiçoamento técnico e ético do trabalho, com idéias e propostas originais e atuais, trata-se, certamente, de contribuição de relevância para aqueles que, direta ou indiretamente, encontram-se engajados na causa do Sistema Único de Saúde.
    Keywords: R5-920 ; Pessoal técnico de saúde-educação ; Ocupação em saúde ; educação profissional ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Deutsche und polnische Juden vor dem Holocaust. Jüdische Identität zwischen Staatsbürgerschaft und Ethnizität 1933-1940 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Creative Spaces (2021)
    University of London Press | University of London Press
    Details
    Publication Date: 2024-04-01
    Description: Creative Spaces: Urban Culture and Marginality is an interdisciplinary exploration of the different ways in which marginal urban spaces have become privileged locations for creativity in Latin America. The essays within the collection reassess dominant theoretical notions of ‘marginality’ in the region and argue that, in contemporary society, it invariably allows for (if not leads to) the production of the new. While Latin American cities have, since their foundation, always included marginal spaces (due, for example, to the segregation of indigenous groups), the massive expansion of informal housing constructed on occupied land in the second half of the twentieth century have brought them into the collective imaginary like never before. Originally viewed as spaces of deprivation, violence, and dangerous alterity, the urban margins were later romanticized as spaces of opportunity and popular empowerment. Instead, this volume analyses the production of new art forms, political organizations and subjectivities emerging from the urban margins in Latin America, neither condemning nor idealizing the effects they produce. To account for the complex nature of contemporary urban marginality, the volume draws on research from a wide spectrum of disciplines, ranging from cultural and urban studies to architecture and sociology. Thus the collection analyzes how these different conceptions of marginal spaces work together and contribute to the imagined and material reality of the wider city.
    Keywords: marginality ; liminality ; urbanity ; diaspora ; migration ; population ; History ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Handwerk und Kleinhandel in der Bundesrepublik Deutschland. Sozialökonomischer Wandel und Mittelstandspolitik 1949–1961 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Immune responses to AAV vectors, from bench to bedside (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
    Language: English
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    Meine Vertreibung aus Prag. Erinnerungen an den Prager Aufstand 1945 und seine Folgen (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Die Kreuzfahrerstaaten als multikulturelle Gesellschaft. Einwanderer und Minderheiten im 12. und 13. Jahrhundert (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: Das international besetzte Kolloquium vom September 1994 widmete sicheinem zuvor vernachlässigten Thema. Es ist eine wesentliche Erkenntnisdes Kolloquiums, daß die Einwanderung - die hier untersucht wird fürden Adel, die Kirche, die Zentralverwaltung, die Wirtschaft und dieKunst - die Kreuzfahrerstaaten vor intellektueller und kulturellerVersteinerung bewahrte und sie auf der Höhe der europäischenEntwicklung hielt. Bei den Minderheiten zeigen mehrere Beiträge dieSchwierigkeiten im Zusammenleben mit den lateinischen Eroberern, mitdenen man trotz aller Abneigung zu fragilen Symbiosen kommen mußte.
    Keywords: D111-203 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: English , French , German
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    Deutsche in Polen nach 1945. Gefangene und Fremde (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Chapter 4 Quarantine in Ceuta and Malta in the travel writings of the late-eighteenth-century Moroccan ambassador Ibn Uthmân Al-Meknassî (2021)
    Manchester University Press | Mediterranean quarantines, 1750–1914: Space, identity and power
    Details
    Publication Date: 2024-04-02
    Description: This chapter examines the writings of the renowned late-eighteenth-century Moroccan ambassador Ibn Uthmân Al-Meknassî, the first known traveller from his country to leave an account of European quarantine as experienced during his two diplomatic missions in Spain’s Ceuta (1779) and Malta’s Valletta (1782). It shows that quarantine, on the one hand, acted as a marker of otherness by which Ibn Othman was identified as a Muslim, though this was not a uniform process, owing to the fact that significant differences existed in the degree of alterity experienced in Spain and Malta, and indeed other parts of the Mediterranean. The subjective opinion on quarantine, on the other hand, was also one of the means through which Ibn Uthmân situated himself within Makhzen (Moroccan government) elites at a time when a division between those who declared themselves in favour of European-style modernisation and those who advocated a rejection of European novelties was already visible.
    Keywords: ibn uthmân al-meknassî ; spain ; diplomatic missions ; morocco ; 18th century ; quarantine ; malta ; muslim identity ; ibn uthmân al-meknassî ; spain ; diplomatic missions ; morocco ; 18th century ; quarantine ; malta ; muslim identity ; Ceuta ; Epidemic ; Mediterranean Sea ; Tangier ; Travel literature ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBX History of medicine
    Language: English
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    An Equal Burden (2021)
    Oxford University Press
    Details
    Publication Date: 2024-04-01
    Description: "An Equal Burden forms the first scholarly study of the Army Medical Services in the First World War to focus on the roles and experiences of the men of the ranks of the Royal Army Medical Corps (RAMC). These men, through their work as stretcher bearers and orderlies, provided a range of labour, both physical and emotional, in aid of the sick and wounded. They were not professional medical caregivers, yet were called upon to provide medical care, however rudimentary; they served in uniform, under military discipline, yet were forbidden, as non-combatants, from carrying weapons. Their service as men in wartime, was thus unique. Structured both chronologically and thematically, this study examines both the work that RAMC rankers undertook and its importance to the running of the chain of medical evacuation. It additionally explores the gendered status of these men within the medical, military and cultural hierarchies of a society engaged in total war, locating their service within the context of that of doctors, female nurses and combatant servicemen. Through close readings of official documents, personal papers, and cultural representations, both verbal and visual, it argues that the ranks of the RAMC formed a space in which non-commissioned servicemen, through their many roles, defined and redefined medical caregiving as men’s work in wartime."
    Keywords: Royal Army Medical Corps ; First World War ; masculinity ; non-combatants ; military medicine ; care giving ; gender history ; cultural representation ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR5 First World War ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBF c 1910 to c 1919::3MPBFB c 1914 to c 1918 (World War One period) ; thema EDItEUR::M Medicine and Nursing
    Language: English
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    Questioning Bodies in Shakespeare's Rome (2021)
    Vandenhoeck & Ruprecht
    Details
    Publication Date: 2024-04-02
    Description: Ancient Rome has always been considered a compendium of City and World. In the Renaissance, an era of epistemic fractures, when the clash between the 'new science' (Copernicus, Galileo, Vesalius, Bacon, etcetera) and the authority of ancient texts produced the very notion of modernity, the extended and expanding geography of ancient Rome becomes, for Shakespeare and the Elizabethans, a privileged arena in which to question the nature of bodies and the place they hold in a changing order of the universe. Drawing on the rich scenario provided by Shakespeare's Rome, and adopting an interdisciplinary perspective, the authors of this volume address the way in which the different bodies of the earthly and heavenly spheres are re-mapped in Shakespeare's time and in early modern European culture. More precisely, they investigate the way bodies are fashioned to suit or deconstruct a culturally articulated system of analogies between earth and heaven, microcosm and macrocosm. As a whole, this collection brings to the fore a wide range of issues connected to the Renaissance re-mapping of the world and the human. It should interest not only Shakespeare scholars but all those working on the interaction between sciences and humanities.
    Keywords: History ; Europe ; Renaissance ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Neumaerkische Staende (Rep. 23 B) (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-01
    Description: Die Publikation gibt einen umfassenden und detaillierten Überblick über den im Brandenburgischen Landeshauptarchiv befindlichen Bestand der Neumärkischen Stände. Die aus dem 16.-19. Jahrhundert stammende Überlieferung wird für jede Akteneinheit durch die Angabe des präzisen Aktentitels und der Laufzeit in einer klaren, nach Sachgebieten systematisch gegliederten Ordnung beschrieben. Die umfangreiche historische Einleitung analysiert Organisation und Wirkungsbereiche der Neumärkischen Stände und stellt in vergleichender Perspektive die bislang vernachlässigte Aussagekraft der Quellen für die frühneuzeitliche Ständegeschichte Deutschlands und Ostmitteleuropas heraus.
    Keywords: Bearbeitet ; Beck ; eingeleitet ; Margot ; Neugebauer ; Neumärkische ; Stände ; Wolfgang ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Communicating Medicine (2021)
    Ledizioni
    Details
    Publication Date: 2023-12-21
    Description: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Keywords: R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
    Language: English
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    Três ensaios de bioética (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Leitores interessados no desenvolvimento teórico da bioética e, ao mesmo tempo, em sua aplicação na solução de conflitos morais certamente encontrarão neste livro materiais de grande valor. Cada capítulo coloca a bioética em um contexto diferente: na clínica, na genômica e na biossegurança. No primeiro ensaio, discutem-se as possibilidades dessa ‘caixa de ferramentas’ chamada bioética para compreender e tentar resolver conflitos de interesses e valores no âmbito das relações entre profissionais e usuários dos serviços de saúde. No segundo, o autor aplica as ferramentas da bioética ao caso dos conflitos morais que envolvem a genômica, contemplando argumentos favoráveis e contrários às práticas da engenharia genética e contribuindo para o raciocínio crítico e sem preconceitos sobre o tema. Por fim, o terceiro capítulo trata da interface entre a bioética e a biossegurança, que têm preocupações comuns, como a questão dos riscos, mas abordagens distintas – enquanto a bioética se ocupa dos valores morais, a biossegurança lança mão de medidas técnicas, administrativas e legais.
    Keywords: R5-920 ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Uneven Encounters (2021)
    Duke University Press | Duke University Press
    Details
    Publication Date: 2024-04-02
    Description: In Uneven Encounters, Micol Seigel chronicles the exchange of popular culture between Brazil and the United States in the years between the World Wars, and demonstrates how that exchange affected ideas of race and nation in both countries. From Americans interpreting advertisements for Brazilian coffee or dancing the Brazilian maxixe, to Rio musicians embracing the “foreign” qualities of jazz, Seigel traces a lively, cultural back and forth. Along the way, she shows how race and nation for both elites and non-elites are constructed together, and driven by global cultural and intellectual currents as well as local, regional, and national ones. Seigel explores the circulation of images of Brazilian coffee and of maxixe in the United States during the period just after the imperial expansions of the early twentieth century. Exoticist interpretations structured North Americans’ paradoxical sense of themselves as productive “consumer citizens.” Some people, however, could not simply assume the privileges of citizenship. In their struggles against racism, Afro-descended citizens living in Rio de Janeiro, São Paulo, New York, and Chicago encountered images and notions of each other, and found them useful. Seigel introduces readers to cosmopolitan Afro-Brazilians and African Americans who rarely traveled far from home but who nonetheless absorbed ideas from abroad. She suggests that studies comparing U.S. and Brazilian racial identities as two distinct constructions are misconceived. Racial formation transcends national borders; attempts to understand it must do the same.
    Keywords: History ; United States ; 20th Century ; Social Science ; Ethnic Studies ; American ; African American & Black Studies ; History ; Latin America ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies
    Language: English
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    Lipid Signaling in T Cell Development and Function (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
    Language: English
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    Foundations of Paleoparasitology (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Unprecedented initiative in the world, the book compiles the available knowledge on the subject and presents the state-of-the-art in paleoparasitology – term coined about 30 years ago by Brazilian Fiocruz researcher Luiz Fernando Ferreira, pioneer in this science which is concerned with the study of parasites in the past. Multidisciplinary by essence, paleoparasitology gathers contributions from social scientists, biologists, historians, archaeologists, pharmacists, doctors and many other professionals, either in biomedical or humanities fields. With varied applications such as in evolutionary or migration studies, their results often depend on the association between laboratory findings and cultural remains. The book is divided into four parts - Parasites, Hosts, and Human Environment; Parasites Remains Preserved in Various Materials and Techniques in Microscopy and Molecular Diagnostics; Parasite Findings in Archeological Remains: a paleographic view; and Special Studies and Perspectives. Signed by authors from various countries such as Argentina, USA, Germany and France, the book has chapters devoted to the discoveries of paleoparasitology on all continents.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: English
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    Okkupation im Osten. Besatzeralltag in Warschau und Minsk 1939-1944 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Translating Early Modern Science (Volume 51) (2021)
    Brill | Brill
    Details
    Publication Date: 2024-04-02
    Description: Translating Early Modern Science explores the roles of translation and the practices of translators in early modern Europe. In a period when multiple European vernaculars challenged the hegemony long held by Latin as the language of learning, translation assumed a heightened significance. This volume illustrates how the act of translating texts and images was an essential component in the circulation and exchange of scientific knowledge. It also makes apparent that translation was hardly ever an end in itself; rather it was also a livelihood, a way of promoting the translator’s own ideas, and a means of establishing the connections that in turn constituted far-reaching scientific networks.
    Keywords: History ; Europe ; Medieval ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Biomedical Insights that Inform the Diagnosis of ME/CFS (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Reading the Irish Woman (2021)
    Liverpool University Press
    Details
    Publication Date: 2024-04-02
    Description: The theme of this book is cultural encounter and exchange in Irish women’s lives. Using three case studies: the Enlightenment, emigration and modernism, it analyses reading and popular and consumer culture as sites of negotiation of gender roles. It traces how the circulation of ideas, fantasies and aspirations which have shaped women’s lives in actuality and in imagination and argues that there were many different ways of being a woman. Attention to women’s cultural consumption and production shows that one individual may in one day identify with representations of heroines of romantic fiction, patriots, philanthropists, literary ladies, film stars, career women, popular singers, advertising models and foreign missionaries. The processes of cultural consumption, production and exchange provide evidence of women’s agency, aspirations and activities within and far beyond the domestic sphere.
    Keywords: History ; Catholic Church ; Dublin ; Ireland ; London ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Keywords: R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
    Language: English
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    Brought to Life by the Voice (2021)
    University of California Press | University of California Press
    Details
    Publication Date: 2024-03-24
    Description: To produce the song sequences that are central to Indian popular cinema, singers' voices are first recorded in the studio and then played back on the set to be lip-synced and danced to by actors and actresses as the visuals are filmed. Since the 1950s, playback singers have become revered celebrities in their own right. Brought to Life by the Voice explores the distinctive aesthetics and affective power generated by this division of labor between onscreen body and offscreen voice in South Indian Tamil cinema. In Amanda Weidman's historical and ethnographic account, playback is not just a cinematic technique, but a powerful and ubiquitous element of aural public culture that has shaped the complex dynamics of postcolonial gendered subjectivity, politicized ethnolinguistic identity, and neoliberal transformation in South India.
    Keywords: Music ; Ethnomusicology ; History ; Asia ; India & South Asia ; Social Science ; Anthropology ; Cultural & Social ; thema EDItEUR::A The Arts::AV Music::AVA Theory of music and musicology ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology
    Language: English
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    Gestion et entretien des bâtiments royaux dans les Pays-Bas autrichiens (1715-1794) (2021)
    Éditions de l'Université de Bruxelles
    Details
    Publication Date: 2024-04-01
    Description: Depuis la gouvernance de Marie de Hongrie, les Gouverneurs généraux chargés de l’administration de nos provinces avaient pour habitude de s’installer à Bruxelles. Pour leur confort et celui de l’importante Cour qui les entourait, le Souverain avait mis à leur disposition l’ensemble de ses biens immobiliers en Brabant. Ces châteaux, maisons, parcs, viviers et autres étaient entretenus à grands frais par une institution spécialement mise en place dans ce but : le Bureau des ouvrages de la Cour. Méconnu jusqu’à présent, cet organisme constituait toutefois une pièce maîtresse dans l’organisation de la vie quotidienne de la Cour de Bruxelles. Les compétences de cette institution ainsi que le personnel qui la composait ont été étudiés à partir des instructions et règlements édictés pour ce département. Ces directives ont ensuite été confrontées aux activités quotidiennes du Bureau pour déterminer dans quelle mesure elles étaient appliquées et/ou adaptées. Enfin, les difficultés éprouvées par ce département dans la gestion de ses affaires ont également été analysées. Grâce à cette étude, un portrait relativement complet du Bureau des ouvrages de la Cour a donc pu être dressé, permettant ainsi de le situer parmi les autres institutions centrales du gouvernement autrichien.
    Keywords: History ; thema EDItEUR::N History and Archaeology::NH History
    Language: French
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    The Pitfalls of Protection (2021)
    University of California Press | University of California Press
    Details
    Publication Date: 2024-04-02
    Description: Since the 2001 overthrow of the Taliban government in Afghanistan, violence against women has emerged as the single most important issue for Afghan gender politics. The Pitfalls of Protection, based on research conducted in Afghanistan between 2009 and 2015, locates the struggles over gender violence in local and global power configurations. Torunn Wimpelmann finds that aid flows and geopolitics have served as both opportunities for and obstacles to feminist politics in Afghanistan. Showing why Afghan activists often chose to use the leverage of Western powers instead of entering into either protracted negotiations with powerful national actors or broad political mobilization, this book examines both the achievements and the limits of this strategy.
    Keywords: History ; General ; History ; Historical Geography ; Social Science ; General ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTP Historical geography ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general
    Language: English
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    Remains of the Social (2021)
    Wits University Press
    Details
    Publication Date: 2024-04-08
    Description: Remains of the Social is an interdisciplinary volume of essays that engages with what ‘the social’ might mean after apartheid; a condition referred to as ‘the post-apartheid social’. The volume grapples with apartheid as a global phenomenon that extends beyond the borders of South Africa between 1948 and 1994 and foregrounds the tension between the weight of lived experience that was and is apartheid, the structures that condition that experience and a desire for a ‘post-apartheid social’ (think unity through difference). Collectively, the contributors argue for a recognition of the ‘the post-apartheid’ as a condition that names the labour of coming to terms with the ordering principles that apartheid both set in place and foreclosed. The volume seeks to provide a sense of the terrain on which ‘the post-apartheid’ - as a desire for a difference that is not apartheid’s difference - unfolds, falters and is worked through.
    Keywords: History ; Apartheid ; Empathy ; Hannah Arendt ; Nelson Mandela ; Psychoanalysis ; Sigmund Freud ; South Africa ; bic Book Industry Communication::H Humanities::HP Philosophy::HPS Social & political philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy
    Language: English
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    Prince, Pen, and Sword: Eurasian Perspectives (2021)
    Brill | Brill
    Details
    Publication Date: 2024-04-01
    Description: A synoptic interpretation of the rulers and elites in Eurasia from the fourteenth to the eighteenth century. Readership: All interested in the early modern global and comparative history of kingdoms and empires, rulers and elites, including area specialists as well as generalists. This book is intended for students and scholars.
    Keywords: History ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    The Schistosomiasis Vaccine - It Is Time to Stand Up (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis.
    Keywords: R5-920 ; RC581-607 ; Schistosomiasis ; Schistosoma mansoni ; Schistosoma haematobium ; Type 2 cytokines ; Vaccine ; Immune responses ; Schistosoma japonicum ; Vaccine candidates ; bic Book Industry Communication::M Medicine
    Language: English
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    Chapter News from the Invisible World (2021)
    Springer Nature | Cultures of Witchcraft in Europe from the Middle Ages to the Present
    Details
    Publication Date: 2024-04-01
    Description: This chapter explores the transmission of tales of the supernatural during the very long eighteenth century (between c.1660 and c.1832). A genre of publications on this subject which have not been studied are those anthologies of supposedly true stories, usually relating to named people and places and sometimes dated, often each numbered separately, with relatively little discussion of their authenticity or significance, beyond perhaps a brief preface defending the reality of the world of spirits. A series of entrepreneurial publishers, mostly operating from Paternoster Row in London, experimented with anthologising these stories in varied combinations. Any attempt to analyse the stories must begin by unravelling the publishing history by which they were transmitted and (not fully studied here) modified and retold, as well as re-interpreted.
    Keywords: publishing; history; supernatural ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::Y Children’s, Teenage and Educational::YN Children’s / Teenage: General interest::YNX Children’s / Teenage general interest: Mysteries and the unexplained ; thema EDItEUR::Y Children’s, Teenage and Educational::YN Children’s / Teenage: General interest::YNX Children’s / Teenage general interest: Mysteries and the unexplained::YNXB Children’s / Teenage general interest: Supernatural and mythological creatures
    Language: English
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    Less and Non-invasive Hemodynamic Monitoring Techniques (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: In the perioperative setting and in intensive care medicine, early and effective hemodynamic management including fluid therapy and administration of vasoactive drugs to maintain vital organ perfusion and oxygen delivery is mandatory. Understanding the different approaches in the management of critically ill patients during the resuscitation and further management is essential to initiate adequate context- and time-specific interventions. Optimization of hemodynamic variables to achieve a balance between organ oxygen delivery and consumption is a cornerstone. In general, cardiac output (i.e., the blood flow) is considered a major determinant of oxygen supply and thus its monitoring is regarded helpful. However, indicators of oxygen requirements are equally necessary to assess adequacy of oxygen supply. Currently, more and more less or even totally non-invasive monitoring systems have been developed and clinically introduced, but they require validation in particular clinical settings. Cardiac output monitors and surrogates of organ oxygenation only enable to adequately guide management, as patient’s outcome is determined by acquisition and interpretation of accurate measurements, and finally, suitable management decisions. This Research Topic focuses on the currently available techniques, especially the less and non-invasive ones, in the field of hemodynamic monitoring in the perioperative setting and in critically ill patients while summarizing their advantages and limitations.
    Keywords: R5-920 ; Blood Pressure ; Cardiovascular dynamics ; goal-directed therapy ; intensive care medicine ; Cardiac Output ; Anesthesiology ; bic Book Industry Communication::M Medicine
    Language: English
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    Kindheit in Byzanz (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-02
    Description: Although there have been many studies of childhood in Ancient Greece and Rome and in the Middle Ages in the West, there is no such study for the Byzantine world. To fill the gap, this bookreconstructs the most important factors in childhood in Byzantium from the 6th through the 11th century. The main sources are the lives of the saints, which are of central importance for the analysis of the social history and daily life of the population. They also provide an insight into family, social and economic structures, as well as patterns of behaviour. This material is supplemented by legal, medical, theological and other sources.
    Keywords: Childhood ; Familiy ; Byzantium ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: German
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    Das Christentum im frühen Europa (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-02
    Description: During the transition from late antiquity to the early Middle Ages, the geographical space of Europe was Christian and Christianity was “European.” The essays present the major theological discourses and decisions of that epoch that helped shape Church and society – from political regents to Church catechesis.
    Keywords: Patristics ; Church history ; Middle Ages ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500 ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAX History of religion
    Language: German , English
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    Gender in medieval places, spaces and thresholds (2021)
    University of London Press | University of London Press | University of London Press
    Details
    Publication Date: 2024-04-11
    Description: This collection addresses the concept of gender in the middle ages through the study of place and space, exploring how gender and space may be mutually constructive and how individuals and communities make and are made by the places and spaces they inhabit. From womb to tomb, how are we defined and confined by gender and by space? Interrogating the thresholds between sacred and secular, public and private, enclosure and exposure, domestic and political, movement and stasis, the essays in this interdisciplinary collection draw on current research and contemporary theory to suggest new destinations for future study.
    Keywords: History ; Europe ; Great Britain ; Norman Conquest To Late Medieval (1066-1485) ; Technology & Engineering ; Agriculture ; bic Book Industry Communication::H Humanities::HB History::HBL History: earliest times to present day::HBLC Early history: c 500 to c 1450/1500
    Language: English
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    Medicamentos no Brasil : inovação e acesso (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Uma das particularidades da área da saúde é pertencer tanto à esfera social quanto à industrial, característica que representa oportunidades e grandes desafios. O livro Medicamentos no Brasil: inovação e acesso tem o objetivo de fomentar o desenvolvimento tecnológico e fortalecer a produção nacional, além de garantir que o conhecimento desses avanços beneficie a população brasileira. Como afirma o ministro da Saúde, José Gomes Temporão, no prefácio: “...inovação não pode estar desligada da idéia de acesso”. Reunindo os pontos de vista da academia, governo e setor produtivo público e privado, com abordagens que privilegiam o contexto nacional e refletem sobre a posição brasileira no cenário internacional, a obra apresenta um diagnóstico da área de medicamentos no país, avalia seus problemas e potencialidades e faz recomendações concretas para superação dos obstáculos e aproveitamento das oportunidades. Cabe destacar que é o segundo volume de uma série sobre pesquisa, desenvolvimento e inovação nos segmentos industriais da saúde, do Projeto Inovação em Saúde (presidência/Fiocruz), cujo primeiro livro é Vacinas, Soros e Imunizações no Brasil.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Die SED und ihre Armee. Die NVA zwischen Politisierung und Professionalismus 1956-1965 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Zeichen und Wunder bei Guibert de Nogent Kommunikation, Deutungen und Funktionalisierungen von Wundererzählungen im 12. Jahrhundert (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: Guibert, Abt von Nogent († um 1125), bekannt vor allem durch seine autobiographische Schrift, tritt uns in seiner polemischen Stellungnahme zum zeitgenössischen Reliquienkult als beinahe aufgeklärter Mensch entgegen. Auf der anderen Seite berichtet er in seinen Werken auch immer wieder von Eingriffen göttlicher oder teuflischer Macht in seine Welt. Karin Fuchs stellt diese Berichte ins Zentrum ihrer Studie: Welche Ereignisse deutete Guibert als Wunder, wie wurden sie kommuniziert, und welche Funktionen hatten überirdische Zeichen in seinen Schriften und für die intellektuelle Gemeinschaft, in der er sich als Mönch und Abt bewegte?
    Keywords: D111-203 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: German
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    Blood-Derived Products for Tissue Repair/Regeneration (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
    Keywords: R5-920 ; RM1-950 ; n/a ; biomaterial ; redifferentiation ; regenerative medicine ; skeletal muscle regeneration ; furcation defects ; Platelet-Rich Plasma (PRP) ; PRP ; fracture ; fibrin sealant ; periodontal surgery ; bone regeneration ; serum derived from plasma rich in growth factors (s-PRGF) ; cartilage repair ; myofibroblasts ; autologous platelet concentrates ; burns ; satellite cells ; articular cartilage ; stem cell niche ; wound healing ; quantification ; growth factors ; biologics ; platelet rich plasma ; meniscus ; adipose tissue ; Carprofen ; platelet-rich fibrin ; platelets ; hyperacute serum ; bone defects ; serum eye drops ; corneal epithelial defect ; fibrosis ; dog ; myoblasts ; differentiation ; chronic meniscal lesion ; horizontal meniscal tear ; PRGF ; collagen hydrogels ; periodontal defects ; bone grafting material ; composition ; cell therapy ; bone healing ; tissue healing ; trephination ; plasma rich plasma (PRP) ; bone repair ; plasma rich in growth factors ; knee arthrosis ; meniscus tear ; cornea regeneration ; wrist osteoarthritis ; periosteal sheet ; Platelet-Poor Plasma (PPP) ; platelet-rich plasma ; microfat ; bone grafting ; hyaluronic acid (NaHA) ; periodontal regeneration ; meniscus repair ; photobiomodulation therapy ; growth ; myogenesis ; blood derived products ; low-level laser therapy ; bic Book Industry Communication::M Medicine
    Language: English
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    To Be Unfree (2021)
    transcript Verlag
    Details
    Publication Date: 2024-04-04
    Description: To Be Unfree is a collection of essays investigating how political unfreedom has been and can be articulated within the republican tradition of political thought. The book combines a theoretical discussion of how freedom and its opposites have been conceptualized in the republican tradition with a broader perspective on this tradition's impact on the representation of unfreedom in Western literature and cultural history. It thus complicates our understanding of what it means to be unfree and unveils a series of distinctions which also shape our modern notions of freedom.
    Keywords: Political Science ; Republicanism ; Political Theory ; History ; Liberty ; Cultural History ; Politics ; Political Philosophy ; Political Ideologies ; Political Science ; Democracy ; Hannah Arendt ; Quakers ; Thomas Hobbes ; Unfreedom ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: English
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