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  • Cham :Springer International Publishing :  (899)
  • Springer Science + Business Media
  • Wiley-Blackwell
  • 2020-2024  (903)
  • 1935-1939
  • 2021  (903)
  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Reproduction. ; Physiology. ; Anatomy. ; Cytology. ; Human Physiology. ; Reproductive Physiology. ; Anatomy. ; Cell Biology.
    Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: Origin and development of the breast -- Chapter 3: Structure of the lactating breast -- Chapter 4: Breast function during the initial period of lactation (lactogenesis I and II) -- Chapter 5: The period of established lactation (lactogenesis III).
    Abstract: This comprehensive Monograph examines all peripheral and central mechanisms of regulating the secretion of milk from the lactating breast. The author reviews the complete female breast development, starting with the early childhood, up to pregnancy and lactation. Structural and ultrastructural data on the alveolar-ductal system, together with details of breast innervation, are used to investigate the physiological process of lactation. Readers will appreciate the special focus on reflexes, both in the child and the mother, that help to regulate maternal milk production and secretion. Following this, the author sheds a light on the composition and dynamics of milk components during the different periods of lactation. The final section of this volume focusses on practical aspects of modern breastfeeding, like the use of breast pumps or galactogogues, to influence the productivity of milk production. These fundamental principles and structural details will be particularly useful for physiologists and clinicians working in gynecology and pediatrics.
    Type of Medium: Online Resource
    Pages: VIII, 254 p. 87 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030663643
    DDC: 612
    Language: English
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  • 2
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    DDC: 615
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Biotechnology. ; Enzymology. ; Bioorganic chemistry. ; Protein Biochemistry. ; Chemical Bioengineering. ; Enzymology. ; Bioorganic Chemistry.
    Description / Table of Contents: Preface -- Chapter 1: Introduction -- Chapter 2: Enzyme Cascade Design – Retrosynthesis Approach -- Chapter 3 : Multi-Enzymatic Cascades in vitro -- Chapter 4: Multi-Enzymatic Cascades in vivo -- Chapter 5: Chemo-Enzymatic Cascades -- Chapter 6: Enzyme Cascade Kinetic Modelling -- Chapter 7: Enzyme Cascade Reaction Engineering -- Chapter 8: Enzyme Cascade Process Design and Modelling -- Chapter 9: Enzyme Cascade Reaction Monitoring And Control -- Chapter 10: Cascade reactions in non-conventional media -- Chapter 11: Perspectives.
    Abstract: This book provides a comprehensive overview of the recent developments achieved in the field of chemo/enzymatic cascades with topics spanning from design (in vitro and in vivo) to kinetic- and process modelling as well as process control. Opportunities and challenges of building multi-step chemo/enzymatic reactions are discussed, whereby the latter are critically assessed in each chapter and methods to ease the implementation are explored. Both, multi-enzymatic cascades and chemo-enzymatic cascades are presented with the motivation of combining the strengths of these two worlds (e.g. selectivity, activity and robustness) not neglecting the obstacles and challenges of such endeavour. Furthermore, the use of non-conventional media for catalytic cascade reactions, recent achievements and potential for future developments in a technical environment are addressed.
    Type of Medium: Online Resource
    Pages: VII, 181 p. 103 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030657185
    DDC: 572.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Radiology. ; Spectrum analysis. ; Pharmaceutical chemistry. ; Nutrition   . ; Biomedical Research. ; Radiology. ; Spectroscopy. ; Pharmaceutics. ; Nutrition.
    Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.
    Abstract: This book introduces the audience with basic theoretical and experimental aspects of Electron Spin Resonance (ESR) Spectroscopy. It further talks about ESR spectroscopy applications in Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science. Mathematical details have been kept to a necessary minimum and emphasis is given to highlight the applications of the technique.
    Type of Medium: Online Resource
    Pages: X, 72 p. 32 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641986
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 610.72
    Language: English
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  • 5
    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    DDC: 615
    Language: English
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  • 6
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Biodiversity. ; Animal migration. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Biodiversity. ; Animal Migration.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. European pearl mussel: background information and literature review -- Chapter 3. Materials and methods -- Chapter 4. Results -- Chapter 5. Discussion -- Chapter 6. Conclusions.
    Abstract: The monograph focuses on the European freshwater pearl mussel Margaritifera margaritifera, which is an endangered bivalve species. Most of its populations in the Russian section of the Baltic Sea basin had never been studied, although they were known in the past to the pearl fishers. “Rediscovery” included search for the previously unknown populations, revealing the facts of population extinctions, analysis of negative impacts, elaboration of conservation measures, and revealing of regularities in distribution. Patterns of land use and river management were analyzed. The procedure of “rediscovery” was applied for other animal species of Northwest Russia, which are threatened on a global scale – thick-shelled mussel, Unio crassus; curlew Numenius arquata; black-tailed godwit, Limosa limosa; Northern Lapwing, Vanellus vanellus; European mink, Mustela lutreola; pond bat, Myotis dasycneme; Atlantic sturgeon, Acipenser sturio; and broad-clawed crayfish, Astacus astacus. The methods and principles of conservation studies were discussed. The obtained data were analyzed with respect to current global change of biosphere. The book will appeal to specialists dealing with conservation studies and activities such as red lists, river protection, and conservation of endangered species. Moreover, a part of the book represents an interest for biogerontology as it presents discredit of the popular concept on “negligible senescence.” The data on distribution of some animals in Russia will be interesting in terms of zoology and biogeography, as they are not yet sufficiently represented in the international editions. The book can be used as supplemental reading for courses in biological invasions, ecology and conservation, and biodiversity. The work also contains chapters on global processes (deforestation, desertification, river degradation) and can therefore also be used for general courses in environmental sciences.
    Type of Medium: Online Resource
    Pages: XI, 246 p. 88 illus., 87 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030662554
    DDC: 577.6
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant biotechnology. ; Plant genetics. ; Agriculture. ; Plant Biotechnology. ; Plant Genetics. ; Agriculture.
    Description / Table of Contents: Economic/Academic importance -- Background of the sequencing initiatives -- Molecular mapping and cloning of genes and QTLs -- Physical mapping of the genome -- Whole genome sequencing and assembling -- Structure and composition of centromere in Brassica genome -- Genome annotation -- Gene loss -- Alternative splicing -- Gene conversion -- Gene family differentiation in Brassica species -- Glucosinates -- R genes variations after triplication -- Structural & functional genomic resources developed -- Impact on plant breeding and crop improvement -- Data bases -- Future prospects.
    Abstract: This book presents comprehensive information on genetics, genomics and breeding in Brassica oleracea, an agriculturally important species that includes popular vegetable crops such as cabbage, cauliflower, broccoli, Brussels sprouts, kale, collard greens, savoy, kohlrabi, and gai lan. The content spans whole genome sequencing, assembly and gene annotation for this global vegetable species, along with molecular mapping and cloning of genes, physical genome mapping and analyses of the structure and composition of centromeres in the B. oleracea genome. The book also elaborates on asymmetrical genome evolution and transposable elements in the B. oleracea describes gene family differentiation in comparison to other Brassica species and structural and functional genomic resources and data bases developed for B. oleracea. Useful discussions on the impact of genome sequencing on genetic improvement in the species are also included.
    Type of Medium: Online Resource
    Pages: XXIV, 145 p. 33 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030310059
    Series Statement: Compendium of Plant Genomes,
    DDC: 631.52
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Hematology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Hematology.
    Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.
    Abstract: It has been 10 years since the first edition of ‘Essentials of Tissue Banking’ has been published. There is still relatively little published on the technical and scientific principles on routine tissue and cell banking based on scientific principles. The 1st edition was very successful and, after a 10 year gap, there is a need of an update and an expansion of the book’s remit. The format of the book follows that of the previous edition- split into 5 sections. Management of donors and the banking of common tissues and cells; Principles of storage and processing of tissues and cells; Ensuring the safety of the products by testing the donor, the tissues and the environment, supported by a quality system and an IT infrastructure- all working within the constraints of current regulatory and ethical environments. This edition however provides a significant update. Many the chapters have been completely rewritten by different experts. Like the 1st edition, they were given a free hand in the way they wrote their chapter, with a guideline that they had to be concise, clear and up to date. The authors were also asked to provide the scientific and technical basis that provides the rationale of the processes they describe. Also, the scope of the book has been somewhat extended. In view of the fact that many cellular therapies are now routinely practiced, 2 new chapters have been added: one on the banking of haematopoietic stem cells and one on human embryonic stem cells. They have been deliberately chosen to illustrate the extreme spectrum of cellular therapies from one of the simplest to one of the most complex. The intention of the book has remained the same: to cover and update banking of current practices in essential tissue and cell banking. It is therefore hoped that by keeping the book as concise and up to date as possible, it will find a place on the shelves of many tissue establishments.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 48 illus., 28 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030716219
    DDC: 610.72
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical microbiology. ; Pharmacology. ; Pediatrics. ; Medical Microbiology. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Part 1 General Vaccinology -- 1 Expected and Unexpected Effects of Vaccination -- 2 How Vaccinating People Can Also Protect Others -- 3 Childhood and Adolescent Immunization Programs in Europe -- 4 Vaccine Hesitancy, Acceptance, and Demand -- 5 Adjuvants in Pediatric Vaccines -- 6 Maternal Immunization -- 7 Neonatal Immunization -- Part 2 Viral Vaccines and Vaccinations -- 8 Poliovirus Vaccines -- 9 Measles–Mumps–Rubella Vaccine -- 10 Varicella Vaccines -- 11 Rotavirus Vaccine -- 12 Hepatitis A Vaccines -- 13 Hepatitis B Vaccines -- 14 Influenza Vaccines -- 15 Human Papillomavirus Vaccines -- 16 Tick-Borne Encephalitis Vaccines -- Part 3 Bacterial Vaccines and Vaccination -- 17 Tuberculosis Vaccines -- 18 Pertussis Vaccines -- 19 Haemophilus influenzae type b (Hib) Vaccines -- 20 Pediatric Combination Vaccines -- 21 Pneumococcal Vaccines -- 22 Meningococcal Vaccines -- 23 Pediatric Vaccines for Travel Outside Europe -- Part 4 New Vaccines in Pipeline Development -- 24 GBS and CMV Vaccines in Pipeline Development -- 25 Norovirus Vaccines in Pipeline Development -- 26 RSV Vaccines and Monoclonal Antibodies in Development -- 27 COVID-19 in Children and COVID-19 Vaccines -- 28 Registration of Vaccines, Safety Follow-Up, and Pediatric Investigation Plan.
    Abstract: This second fully updated and extended edition of the textbook serves as a highly readable guide on latest developments in vaccine development and vaccination programs in infants, children and adolescents from a European perspective. The first part of the book introduces to general vaccinology, immunization programs and formulation, effects and unwanted effects of vaccines. The second and third part provide an overview on current viral and bacterial vaccines. The fourth and last part of this book discusses new vaccines in the pipeline and gives insights into safety and regulatory matters. This second edition is extended by a whole new chapter on COVID-19 vaccines. This book serves as a reference textbook in the field and helps to standardize the information on vaccines and immunization programs in the WHO European Region.
    Type of Medium: Online Resource
    Pages: XIII, 319 p. 66 illus., 63 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030771737
    DDC: 616.9041
    Language: English
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  • 10
    Keywords: Agriculture. ; Botany. ; Agriculture. ; Plant Science.
    Description / Table of Contents: Preface -- Part I: Leaves -- Chapter 1. Advances in Chicory (Cichorium intybus L.) Breeding Strategies (Laila Aldahak, Khaled F. M. Salem, Salih H. F. Al-Salim, and Jameel M. Al-Khayri) -- Chapter 2. Chinese Cabbage (Brassica rapa L. var. pekinensis) Breeding: Application of Molecular Technology (Takumi Okamoto, Xiaochun Wei, Hasan Mehraj, Mohammad Rashed Hossain, Ayasha Akter, Naomi Miyaji, Yoshinobu Takada, Jong-In Park, Ryo Fujimoto, Ill-Sup Nou, and Masao Watanabe) -- Chapter 3. Breeding Advances and Prospects in Rocket Salad (Eruca vesicaria ssp. sativa Mill.) Cultivation (Pasquale Tripodi, Paula Santos Coelho, and Carla Guijarro-Real) -- Chapter 4. Spring Onion (Allium fistulosum L.) Breeding Strategies (Fatimah Kayat, Ahmed Mahmood Ibrahim, and Arifullah Mohammed) -- Chapter 5. Water Spinach (Ipomoea aquatica Forsk.) Breeding (Moumita Gangopadhyay, Anup Kumar Das, Subhendu Bandyopadyay, and Samanwita Das) -- Chapter 6. Watercress (Nasturtium officinale R. Br.) Breeding (Mohammadreza Hassandokht, Sajad Jafari, and Raheleh Ebrahimi) -- Part II: Flowerheads and Green Pods -- Chapter 7. Advances in Cauliflower (Brassica oleracea var. botrytis L.) Breeding, with Emphasis on India (Pritam Kalia and Shrawan Singh) -- Chapter 8. Globe Artichoke (Cynara cardunculus var. scolymus L.) Breeding (Fernando López-Anido and Eugenia Martin) -- Chapter 9. Breeding Strategies of Garden Pea (Pisum sativum L.) (Amal M.E. Abdel Hamid and Khaled F.M. Salem) -- Chapter 10. Genetic Improvement of Yardlong Bean (Vigna unguiculata (L.) Walp. ssp. sesquipedalis (L.) Verdc.) (Pidigam Saidaiah, Thuraga Vishnukiran, Someswar Rao Pandravada, Natarajan Sivaraj, Adimulam Srivani, Amarapalli Geetha, Nimmarajula Srinivas, and Venkateswaran Kamala) -- Part III: Mushrooms -- Chapter 11. Enoki Mushroom (Flammulina velutipes (Curtis) Singer) Breeding (Ved P. Sharma, Anupam Barh, Rakesh Kumar Bairwa, Sudheer K. Annepu, Babita Kumari and Shwet Kamal) -- Chapter 12. Shiitake Mushroom (Lentinula edodes (Berk.) Sing.) Breeding in China (Quanju Xiang, Bilal Adil, Qiang Chen, Yunfu Gu, Xianfu Zeng, and Xinzhu Li) -- Part IV: Truffles -- Chapter 13. Desert Truffles (Terfezia spp.) Breeding (Asunción Morte, Francisco Arenas, José E. Marqués-Gálvez, Alberto Andrino, Ángel L. Guarnizo, Almudena Gutiérrez, Luis Miguel Berná, Manuela Pérez-Gilabert, Antonio Rodríguez, and Alfonso Navarro-Ródenas) -- Chapter 14. Enhancing White Truffle (Tuber magnatum Picco and T. borchii Vittad.) Cultivation through Biotechnology Innovation (Alessandra Zambonelli, Mirco Iotti, Federico Puliga, and Ian R. Hall).
    Abstract: Plant breeders and geneticists are under constant pressure to sustain and expand food production by using innovative breeding strategies and introducing minor crops, which are well adapted to marginal lands, provide a source of nutrition, and have abiotic and biotic stress tolerance, to feed an ever-increasing human population. The basic concept of this book is to examine the use of innovative methods, augmenting traditional plant breeding, towards the improvement and development of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. Three volumes of the book series Advances in Plant Breeding Strategies were published in 2015, 2016 and 2018, respectively: Volume 1. Breeding, Biotechnology and Molecular Tools; Volume 2. Agronomic, Abiotic and Biotic Stress Traits and Volume 3. Fruits. In 2019, the following four volumes were published: Volume 4. Nut and Beverage Crops, Volume 5. Cereals, Volume 6. Industrial and Food Crops and Volume 7. Legumes. Recent volumes published in 2021 include: Volume 8. Vegetable Crops: Bulbs, Roots and Tubers, Volume 9. Vegetable Crops: Fruits and Young Shoots and Volume 10. Vegetable Crops: Leaves, Flowerheads, Green Pods, Mushrooms and Truffles. This Volume 10, subtitled Vegetable Crops: Leaves, Flowerheads, Green Pods, Mushrooms and Truffles, consists of 14 chapters focusing on advances in breeding strategies using both traditional and modern approaches for the improvement of individual vegetable crops. Chapters are arranged in 4 parts according to the edible vegetable parts. Part I: Leaves - Chicory, Chinese cabbage, Rocket salad, Spring onion, Water spinach and Watercress; Pat II: Flowerheads and Green Pods - Cauliflower, Globe artichoke, Garden pea and Yardlong bean; Part III: Mushrooms - Enoki mushroom and Shiitake mushroom; Part IV: Truffles - Desert truffles and White truffle. Each chapter comprehensively reviews the contemporary literature on the subject and reflects the experiences of the authors. Chapters are written by internationally-reputable scientists and subjected to a review process to assure quality presentation and scientific accuracy. Each chapter begins with an introduction covering related backgrounds and provides in-depth discussion of the subject supported with high-quality color photos, illustrations and relevant data. The chapter concludes with recommendations for future research directions, a comprehensive list of pertinent references to facilitate further reading, and appendixes of genetic resources and concerned research institutes. This book series is a valuable resource for advanced students, researchers, scientists, commercial producers and seed companies as well as consultants and policymakers interested in agriculture, particularly in modern breeding technologies.
    Type of Medium: Online Resource
    Pages: XVII, 540 p. 98 illus., 76 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030669690
    DDC: 630
    Language: English
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  • 11
    Keywords: Plant anatomy. ; Stress (Physiology). ; Plants. ; Plant physiology. ; Plant ecology. ; Plants Development. ; Agriculture. ; Plant Anatomy and Morphology. ; Plant Stress Responses. ; Plant Physiology. ; Plant Ecology. ; Plant Development. ; Agriculture.
    Description / Table of Contents: Crosstalk between autophagy and hormones for abiotic stress tolerance in plants -- Abscisic acid and plant response under adverse environmental conditions -- Auxins and plant response to adverse environmental conditions -- Jasmonic acid for sustainable plant growth and production under adverse environmental conditions -- Salicylic acid for vigorous plant growth and enhanced yield under harsh environment -- Strigolactones for sustainable plant growth and production under adverse environmental conditions -- Polyamines for sustainable plant growth and production under adverse environmental conditions -- Plant performance and defensive role of proline under environmental stress -- Plant performance and defensive role of β-amino butyric acid under environmental stress -- Plant performance and defensive role of γ-gamma amino butyric acid under environmental stress -- Nitric oxide: A key modulator of plant responses under environmental stress -- Functions of hydrogen sulfide in plant regulation and response to abiotic stress -- Silicon and plant responses under adverse environmental conditions -- Nanofertilizers as tools for plant nutrition and plant biostimulation under adverse environment -- Biostimulants and plant response under adverse environmental conditions: a functional interplay -- Biofertilizers-mediated sustainable plant growth and production under adverse environmental conditions -- Seed priming: A cost-effective strategy to impart abiotic stress tolerance -- Significance of cyanobacteria in soil-plant system and for ecological resilience -- Phytomicrobiome community: An agrarian perspective -- Adverse environment and pest management for sustainable plant production -- Eco-friendly approaches of using weeds for sustainable plant growth and production.
    Abstract: Global climate change is bound to create a number of abiotic and biotic stresses in the environment, which would affect the overall growth and productivity of plants. Like other living beings, plants have the ability to protect themselves by evolving various mechanisms against stresses, despite being sessile in nature. They manage to withstand extremes of temperature, drought, flooding, salinity, heavy metals, atmospheric pollution, toxic chemicals and a variety of living organisms, especially viruses, bacteria, fungi, nematodes, insects and arachnids and weeds. Incidence of abiotic stresses may alter the plant-pest interactions by enhancing susceptibility of plants to pathogenic organisms. These interactions often change plant response to abiotic stresses. Plant growth regulators modulate plant responses to biotic and abiotic stresses, and regulate their growth and developmental cascades. A number of physiological and molecular processes that act together in a complex regulatory network, further manage these responses. Crosstalk between autophagy and hormones also occurs to develop tolerance in plants towards multiple abiotic stresses. Similarly, biostimulants, in combination with correct agronomic practices, have shown beneficial effects on plant metabolism due to the hormonal activity that stimulates different metabolic pathways. At the same time, they reduce the use of agrochemicals and impart tolerance to biotic and abiotic stress. Further, the use of bio- and nano-fertilizers seem to hold promise to improve the nutrient use efficiency and hence the plant yield under stressful environments. It has also been shown that the seed priming agents impart stress tolerance. Additionally, tolerance or resistance to stress may also be induced by using specific chemical compounds such as polyamines, proline, glycine betaine, hydrogen sulfide, silicon, β-aminobutyric acid, γ-aminobutyric acid and so on. This book discusses the advances in plant performance under stressful conditions. It should be very useful to graduate students, researchers, and scientists in the fields of botanical science, crop science, agriculture, horticulture, ecological and environmental science.
    Type of Medium: Online Resource
    Pages: XIV, 606 p. 54 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030785215
    DDC: 571.32
    Language: English
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  • 12
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Biophysics. ; Cell interaction. ; Cytology. ; Cancer Microenvironment. ; Mechanobiological Cell Signaling. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 191 p. 31 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030471897
    Series Statement: Advances in Experimental Medicine and Biology, 1270
    DDC: 571.978
    Language: English
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  • 13
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Genetics. ; Molecular biology. ; Cancer Biology. ; Genetics and Genomics. ; Molecular Biology.
    Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.
    Abstract: Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.
    Type of Medium: Online Resource
    Pages: XVII, 167 p. 72 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030756994
    DDC: 571.978
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Invertebrates. ; Parasitology. ; Veterinary microbiology. ; Invertebrate Zoology. ; Parasitology. ; Veterinary Microbiology.
    Description / Table of Contents: 1.Origin and evolution of Triatominae -- 2. Taxonomy -- 3. Speciation Processes in Triatominae -- 4. Chromosome structure and evolution of Triatominae: A review -- 5. Embryonic development of the kissing bug Rhodnius prolixus -- 6. Anatomy of the nervous system of triatomines -- 7. Biogenic monoamines in the control of triatomine physiology with emphasis on Rhodnius prolixus -- 8. Structure and physiology of the neuropeptidergic system of triatomines -- 9. Sensory biology of triatomines -- 10. The behaviour of kissing-bugs -- 11. Features of interaction between triatomines and vertebrates based on bug feeding parameters -- 12. Blood Digestion in Triatomine Insects -- 13. The physiology of sperm transfer and egg production in vectors of Chagas disease with particular reference to Rhodnius prolixus -- 14. The Immune System of Triatomines -- 15. Interaction of triatomines with their bacterial microbiota and trypanosomes -- 16. The ecology and natural history of wild Triatominae in the Americas -- 17. Eco-epidemiology of vector-borne transmission of Trypanosoma cruzi in domestic habitats -- 18. Chagas Disease Vector Control -- 19. Insecticide resistance in triatomines -- 20. Perspectives in triatomine biology studies: “Omics”- based approaches.
    Abstract: This book aims to present updated knowledge on various aspects of the natural history, biology, and impact of triatomines to all interested readers. Each chapter will be written by authorities in the respective field, covering topics such as behavior, neurophysiology, immunology, ecology, and evolution. The contents will consider scientific, as well as innovative perspectives, on the problems related to the role of triatomine bugs as parasite vectors affecting millions in the Latin American region.
    Type of Medium: Online Resource
    Pages: XXX, 620 p. 62 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030645489
    Series Statement: Entomology in Focus, 5
    DDC: 592
    Language: English
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  • 15
    Keywords: Nervous system Surgery. ; Neuropsychology. ; Neurology . ; Neurosurgery. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: Foreword -- Preface -- Part I: Sensorimotor and visuo-spatial functions -- 1. Motor control -- 2. Vision -- 3. FEF -- 4. Spatial cognition -- Part II: Language functions -- 5. Lexical access -- 6. Spontaneous speech -- 7. Reading -- 8. Writing -- 9. Repeating -- 10. Syntactic abilities -- 11. Verbs versus nouns naming -- 12. Verbal short-term memory -- 13. Proper names retrieval -- 14. Bilingual patients -- Part III: Higher-order functions -- 15. From verbal to non-verbal semantics -- 16. Inhibition -- 17. Set-shifting -- 18. Social cognition -- 19. Multitask mapping -- Part IV: Prospects -- 20. Creativity -- 21. Psychiatric and behavorial traits -- 22. Awake surgery in patients with poor abilities of verbal communication -- 23. Can we map inner speech? -- 24. Beyond tasks: when experience shapes intuition.
    Abstract: This book aims to give the state-of-the-art of intraoperative brain function mapping for resection of brain tumors in awake conditions, and to become a reference for acquiring the fundamental expertise necessary to select the right intraoperative task at the right time of the surgery. The chapters, all focused on a specific brain function, are divided in 4 parts: sensori-motor and visuo-spatial functions, language functions, higher-order functions, and prospects. Each chapter follows the same outline, including a brief review of the current knowledge about the networks sustaining the function in healthy subjects, the description of the intraoperative tasks designed to monitor the function, a review of the literature describing the deficits in that function after surgery, and a critical appraisal of the benefit provided by intraoperative mapping of that function.
    Type of Medium: Online Resource
    Pages: XIV, 421 p. 93 illus., 90 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030750718
    DDC: 617.48
    Language: English
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  • 16
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Artificial intelligence. ; Artificial Intelligence.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Literature Review -- Chapter 3. Data Analysis -- Chapter 4. SynTime: Token Types and Heuristic Rules -- 5. TOMN: Constituent-based Tagging Scheme -- Chapter 6. UGTO: Uncommon Words and Proper Nouns -- Chapter 7. Conclusion and Future Work.
    Abstract: This book presents a synthetic analysis about the characteristics of time expressions and named entities, and some proposed methods for leveraging these characteristics to recognize time expressions and named entities from unstructured text. For modeling these two kinds of entities, the authors propose a rule-based method that introduces an abstracted layer between the specific words and the rules, and two learning-based methods that define a new type of tagging scheme based on the constituents of the entities, different from conventional position-based tagging schemes that cause the problem of inconsistent tag assignment. The authors also find that the length-frequency of entities follows a family of power-law distributions. This finding opens a door, complementary to the rank-frequency of words, to understand our communicative system in terms of language use.
    Type of Medium: Online Resource
    Pages: XIX, 96 p. 17 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030789619
    Series Statement: Socio-Affective Computing, 10
    DDC: 006.3
    Language: English
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  • 17
    Keywords: Agriculture. ; Botany. ; Agriculture. ; Plant Science.
    Description / Table of Contents: Preface -- Part I: Bulbs -- Chapter 1. Traditional and Novel Approaches in Garlic (Allium sativum L.) Breeding (Einat Shemesh-Mayer and Rina Kamenetsky Goldstein) -- Chapter 2. Genetic Improvement of Leek (Allium ampeloprasum L.) (Fevziye Celebi-Toprak and Ali Ramazan Alan) -- Chapter 3. Shallot (Allium cepa L. Aggregatum group) Breeding (Haim D. Rabinowitch) -- Part II: Roots -- Chapter 4. Molecular Breeding Strategies of Beetroot (Beta vulgaris ssp. vulgaris var. conditiva Alefeld) (Farrag F.B. Abu-Ellail, Khaled F.M. Salem, Maysoun M. Saleh, Lina M. Alnaddaf, and Jameel M. Al-Khayri) -- Chapter 5. Carrot (Daucus carota L.) Breeding (Philipp W. Simon) -- Chapter 6. Parsnip (Pastinaca sativa L.) Breeding for the Future (Lauren H.K. Chappell and Adrian J. Dunford) -- Chapter 7. Radish (Raphanus sativus L.): Breeding for Higher Yield, Better Quality and Wider Adaptability (Binod Kumar Singh) -- Chapter 8. Sugar Beet (Beta vulgaris ssp. vulgaris L.) Improvement with Next-generation Breeding Technology (Chiara De Lucchi, Enrico Biancardi, George Skaracis, Marco De Biaggi, Ourania Pavli, Samathmika Ravi, Claudia Chiodi, Chiara Broccanello, and Piergiorgio Stevanato) -- Chapter 9. Turnip (Brassica rapa var. rapa L.) Breeding (Hesham S. Abdel-Razzak) -- Part III: Tubers -- Chapter 10. Recent Advances in Potato (Solanum tuberosum L.) Breeding (Emre Aksoy, Ufuk Demirel, Allahbakhsh Joiya, Muhammad Abu Bakar Zia, Muhammad Naeem Sattar, Faisal Saeed, Sevgi Çalışkan, and Mehmet Emin Çalışkan) -- Chapter 11. Application of Genome Editing Tools to Accelerate Potato (Solanum tuberosum L.) Breeding (Zafar Iqbal and Muhammad Naeem Sattar) -- Chapter 12. Sweet potato (Ipomoea batatas L.) Breeding (Jolien Swanckaert, Dorcus Gemenet, Noelle L. Anglin, and Wolfgang Grüneberg).
    Abstract: Plant breeders and geneticists are under constant pressure to sustain and expand food production by using innovative breeding strategies and introducing minor crops, which are well adapted to marginal lands, provide a source of nutrition, and have abiotic and biotic stress tolerance, to feed an ever-increasing human population. The basic concept of this book is to examine the use of innovative methods, augmenting traditional plant breeding, towards the improvement and development of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. Three volumes of the book series Advances in Plant Breeding Strategies were published in 2015, 2016 and 2018, respectively: Volume 1. Breeding, Biotechnology and Molecular Tools; Volume 2. Agronomic, Abiotic and Biotic Stress Traits and Volume 3. Fruits. In 2019, the following four volumes were published: Volume 4. Nut and Beverage Crops, Volume 5. Cereals, Volume 6. Industrial and Food Crops and Volume 7. Legumes. Recent volumes published in 2021 include: Volume 8. Vegetable Crops: Bulbs, Roots and Tubers, Volume 9. Vegetable Crops: Fruits and Young Shoots and Volume 10. Vegetable Crops: Leaves, Flowerheads, Green Pods, Mushrooms and Truffles. This Volume 8, subtitled Vegetable Crops: Bulbs, Roots and Tubers, consists of 12 chapters focusing on advances in breeding strategies using both traditional and modern approaches for the improvement of individual vegetable crops. Chapters are arranged in 3 parts according to the edible vegetable parts. Part I: Bulbs - Garlic, Leek and Shallot; Part II: Roots - Beetroot, Carrot, Parsnip, Radish, Sugar beet and Turnip, Part III: Tubers - Potato and Sweet potato. Each chapter comprehensively reviews the contemporary literature on the subject and reflects the experiences of the authors. Chapters are written by internationally-reputable scientists and subjected to a review process to assure quality presentation and scientific accuracy. Each chapter begins with an introduction covering related backgrounds and provides in-depth discussion of the subject supported with high-quality color photos, illustrations and relevant data. The chapter concludes with recommendations for future research directions, a comprehensive list of pertinent references to facilitate further reading, and appendixes of genetic resources and concerned research institutes. This book series is a valuable resource for advanced students, researchers, scientists, commercial producers and seed companies as well as consultants and policymakers interested in agriculture, particularly in modern breeding technologies.
    Type of Medium: Online Resource
    Pages: XV, 554 p. 105 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030669652
    DDC: 630
    Language: English
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  • 18
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Using electrical stimulation to explore and augment the functions of parietal-frontal cortical networks in primates -- 2. Multi-system benefits of epidural stimulation following spinal cord injury. 3. Neurostimulator for hippocampal memory prosthesis -- 4. Modern approaches to augmenting the brain functions -- 5. Brain machine interfaces within a critical perspective -- 6. An implantable wireless device for ECoG and cortical stimulation -- 7. BCI Performance improvement by special low jitter quasi-steady State VEP paradigm -- 8. Communication with Brain-Computer Interfaces in Medical Decision-Making -- 9. Neuroprotection and neurocognitive augmentation by photobiomodulation -- 10. Avoiding partial sleep - the way for augmentation of brain function -- 11. Augmentation of brain functions by nanotechnology -- 12. The impact of ageing and age-related comorbidities on stroke outcome in animal models and humans -- 13. Diagnostic markers of sub-clinical depression based on functional connectivity -- 14. Transcranial magnetic stimulation in autism spectrum disorders: modulating brainwave abnormalities and behaviors -- 15. Neurofeedback training with concurrent psychophysiological monitoring in children with autism spectrum disorder with comorbid attention deficit/hyperactivity disorder -- 16. Augmentation through interconnection: brain-nets and telemedicine -- 17. Cognitive augmentation via a brain/cloud interface -- 18. Augmentation of neuro-marketing by neural technology -- 19. Augmentation of nutrition by nanotechnology -- 20. Neural spintronics: noninvasive augmentation of brain functions -- 21. Does the power to suppress an action make us free? -- 22. Deep brain stimulation for Parkinson’s disease-future directions for enhancing motor function -- 23. Neuromodulation for gait -- 24. Augmentation and rehabilitation with active orthotic devices -- 25. Effects of rTMS on behavioral and electrocortical measures of error monitoring and correction function in children with autism spectrum disorder -- 26. Affective Virtual Reality Gaming for Autism -- 27. A machine learning approach to automatic phobia therapy with virtual reality -- 28. Vision augmentation by pharmacological enhancement of the visual experience -- 29. Cognitive enhancing substances and the developing brain: risks and benefits -- 30. Pharmacological approaches in the augmentation and recovery of brain function.
    Abstract: This book covers recent advances in the neural technology that produces enhancements for brain function. It addresses a broad range of neural phenomena occurring in the brain circuits for perception, cognition, emotion and action, representing the building blocks of the behavior and mind. Augmentation of brain function is achieved using brain implants for recordings, stimulation and drug delivery. Alternative methods include employing brain-machine interfaces, as well as noninvasive activation of certain brain areas. Existing methods of brain augmentation are evaluated, and new approaches are introduced. Brain circuitry and neuronal mechanisms that are candidates for augmentation are discussed. This volume provides novel insights into brain disorders, and new devices for brain repair. Information in this book is relevant to researchers in the field of neuroscience, engineering, and clinical practice. Philosophical and ethical implications of brain augmentation are also addressed. “This impressive book by leading experts in neuroscience and neuroengineering lays out the future of brain augmentation, in which the human mind and machine merge, leading to a rapid exponential growth of the power of humanity.” – Ray Kurzweil "This book employs a holistic approach in covering the recent advances in the fields of neuroscience, neuroinformatics, neurotechnology and neuro-psycho-pharmacology. Each chapter of the book covers major aspects of modern brain research in connection with the human mind and behavior, and is authored by researchers with unique expertise in their field. " – Ioan Dumitrache “This book presents compelling perspectives on what interactive neuroscience will look like in the future, delving into the innovatory ideas of a diverse set of neuroscientists, and speculating on the different ways computer chips implanted in the brains of humans can effect intelligence and communication.” – György Buzsáki.
    Type of Medium: Online Resource
    Pages: XXII, 747 p. 189 illus., 153 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030545642
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 19
    Keywords: Zoology. ; Environment. ; Bioinformatics. ; Ecology . ; Biodiversity. ; Physical geography. ; Zoology. ; Environmental Sciences. ; Computational and Systems Biology. ; Ecology. ; Biodiversity. ; Earth System Sciences.
    Description / Table of Contents: Introduction -- Historical review of research on Arctic and Subarctic Aleocharinae -- Material and methods -- Impact of climate change on northern fauna and flora -- Aleocharinae as indicators of change -- Faunal analysis and discussion -- Key to tribes occurring in Arctic and Subarctic zones -- Tribe Gymnusini Heer, 1839 -- Tribe Aleocharini Fleming, 1821 -- Tribe Oxypodini C.G. Thomson, 1859 -- Tribe Tachyusini C.G. Thomson, 1859 -- Tribe Hypocyphtini Laporte, 1835 -- Tribe Myllaenini Ganglbauer, 1895 -- Tribe Liparocephalini Fenyes, 1918 -- Tribe Homalotini Heer, 1839 -- Tribe Placusini Mulsant and Rey, 1871 -- Tribe Athetini Casey, 1910 -- Tribe Falagriini Mulsant and Rey, 1873.
    Abstract: Arctic and Subarctic North America is particularly affected by climate change, where average temperatures are rising three times faster than the global average. Documenting the changing climate/environment of the north requires a structured knowledge of indicator taxa that reflect the effects of climate changes. Aleocharine beetles are a dominant group of forest insects, which are being used in many projects as indicators of environmental change. Many species are forest specialists restricted to certain microhabitats, some are generalists and others are open habitat specialists. They represent many ecological niches and, as such, are good indicators for many other species as well. The majority of Canadian aleocharine beetle species (about 600 spp.) has been studied and published by Jan Klimaszewski et al. (2018, 2020), mainly from southern, central, and western Canada, while the northern taxa remain poorly known and documented. The aim of the present book is to summarize the knowledge on this insect group in the Arctic and Subarctic North America and to provide a diagnostic and ecological tool for scientists studying and monitoring insects in northern Canada and Alaska. The book includes a review of the literature, information on 238 species and their habitats, taxonomic review, images, and identification tools.
    Type of Medium: Online Resource
    Pages: XIV, 712 p. 315 illus., 307 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030681913
    DDC: 590
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Reproductive health. ; Cytology. ; Biomedical Research. ; Reproductive Medicine. ; Cell Biology.
    Description / Table of Contents: Ch 1: The seminiferous epithelial cycle of spermatogenesis: Role of non-receptor protein kinases -- Ch 2: Sertoli cells: immunology and spermatogenesis -- Ch 3: Innate immunity and spermatogenesis -- Ch 4: Cell apoptosis and spermatogenesis -- Ch 5: Transcriptional regulation of spermatogenesis -- Ch 6: Sertoli cell cytoskeleton and spermatogenesis -- Ch 7: Leydig cell and spermatogenesis -- Ch 8: Cross-talk of cell junctions to support spermatogenesis -- Ch 9: Coordination of F-actin- and MT-based cytoskeletons to support spermatogenesis -- Ch 10: Regulation of the blood-testis barrier by basement membrane laminin-α2 chain -- Ch 11: Regulation of spermatogenesis by collagens -- Ch 12: Androgen regulation of spermatogenesis -- Ch 13: Use of molecular modeling to study spermatogenesis -- Ch 14: Acrosome biogenesis during spermatogenesis -- Ch 15: Stem cells and spermatogenesis -- Ch 16: Advances in our understanding of spermatogenesis in humans -- Ch 17: Leydig cell function in aging men -- Ch 18: Regulation of human spermatogenesis.
    Abstract: This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.
    Type of Medium: Online Resource
    Pages: X, 319 p. 44 illus., 40 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030777791
    Series Statement: Advances in Experimental Medicine and Biology, 1381
    DDC: 610.72
    Language: English
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  • 21
    Keywords: Veterinary medicine. ; Medicine Research. ; Biology Research. ; Biometry. ; Veterinary Science. ; Biomedical Research. ; Biostatistics.
    Description / Table of Contents: An introduction to reproducibility in the context of animal research -- Rodent Genetics -- Animal and environmental factors that influence reproducibility -- Microbiology and Microbiome -- Effects of untreated pain, anesthesia and analgesia in animal experimentation -- Why do we need a statistical experiment design -- Statistical tests and Sample size calculations -- Design of experiments -- Scholarly Publishing and Scientific Reproducibility -- Systematic reviews -- Planning animal experiments.
    Abstract: This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. The book addresses advanced undergraduates, graduate students and all scientists working with animals.
    Type of Medium: Online Resource
    Pages: VI, 277 p. 52 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030661472
    Series Statement: Laboratory Animal Science and Medicine, 1
    DDC: 636.089
    Language: English
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  • 22
    Keywords: Botany. ; Nutrition   . ; Medicinal chemistry. ; Food science. ; Plant Science. ; Nutrition. ; Medicinal Chemistry. ; Food Science.
    Description / Table of Contents: Foreword -- Preface -- Wetlands and Wetland Plants -- Climate of Wetlands -- Types of Wetlands and Wetland Plants -- Importance of Biodiversity in Wetlands -- Nutritive Value of Wetland Flora -- Medicinally Important Wetland Flora -- Threats to Biodiversity of Wetlands -- Conservation Strategies of Wetland Flora -- Wetland Plants of Himalayas: A case study -- A Pictorial Guide to Wetland plants of Himalayas -- Bibliography.
    Abstract: Due to their high nutritive value and the presence of secondary metabolites, wetland plants can be consumed by humans as food and utilized as medicinal drugs. Significant numbers of ethno-botanic resources have been reported to extract useful compounds, which can be used as pharmaceuticals. Wetland plants are also very valuable as an energy source, as fuel for fish smoking and for domestic energy. These plants can be harvested as wild stock, or cultivated in flooded paddies for aquaculture, food and for livestock fodder. All parts of plants can be utilized for foodstuff, compost, mulch, medicine, and for construction. Wetland Plants: A Source of Nutrition and Ethnomedicine aims to promote public understanding of this remarkable resource, exploring not only their role in the ecosystem but also their nutritional and medicinal purposes. Based on original research, the text focuses on species identification (with original pictures of wetland plants including morphological features), nutritive value and ethno-medicinal uses. This book serves as an important and basic reference material for further research into the basic biological as well as the applied medicinal aspects of traditional medicinal wetland plants.
    Type of Medium: Online Resource
    Pages: XXIX, 228 p. 149 illus., 148 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030692582
    DDC: 580
    Language: English
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  • 23
    Keywords: Environmental chemistry. ; Environmental health. ; Pollution. ; Environmental monitoring. ; Toxicology. ; Green chemistry. ; Environmental Chemistry. ; Environmental Health. ; Pollution. ; Environmental Monitoring. ; Toxicology. ; Green Chemistry.
    Description / Table of Contents: Chapter 1 Determination of Pesticide Residues in Fish -- Chapter 2 Analysis of Pesticide Residues in Pollen and Dairy Products -- Chapter 3 Monitoring and Evaluation of Pesticide Residues in Aquatic Systems -- Chapter 4 Pyrethroid and Residues in Chickens and Poultry Litter -- Chapter 5 Extraction Procedures and Chromatography of Pesticides Residues in Strawberries -- Chapter 6 Non-extractable Pesticide Residues in Soils -- Chapter 7 Pyrethroids Metabolites in Human Urine Samples -- Chapter 8 Remediation of Pesticide in Water -- Chapter 9 Strategy for the Inspection of Pesticide Residues in Food and Agriculture -- Chapter 10 Toxic Effects of Pesticides on Avifauna Inhabiting Wetlands -- Chapter 11 Analysis of Pesticide Residues in Biotic Matrices.
    Abstract: This book presents recent reviews on the occurrence, analysis, toxicity and remediation of pesticides in biological systems such as fish, chickens, water, soil and food.
    Type of Medium: Online Resource
    Pages: XV, 373 p. 96 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030547127
    Series Statement: Sustainable Agriculture Reviews, 47
    DDC: 577.14
    Language: English
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  • 24
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Life sciences. ; Cytology. ; Protein Biochemistry. ; Life Sciences. ; Cell Biology.
    Description / Table of Contents: Chapter 1. Structure, Dynamics and Function of the 26S Proteasome -- Chapter 2. Factor VIII and Factor V Membrane Bound Complexes -- Chapter 3. An Overview of DPS: Dual Acting Nanovehicles in Prokaryotes with DNA Binding and Ferroxidation Properties -- Chapter 4. Structure and Function of the Separase-Securin Complex -- Chapter 5. The DNA Replication Machine: Structure and Dynamic Function -- Chapter 6. Recent Progress in Structural Studies on the GT-C Superfamily of Protein Glycosyltransferases -- Chapter 7. How Structures of Complement Complexes Guide Therapeutic Design -- Chapter 8. Architecture and Assembly of the Bacterial Flagellar Motor Complex -- Chapter 9. Cellulosomes: Highly Efficient Cellulolytic Complexes -- Chapter 10. Leucine Dehydrogenase: Structure and Thermostability -- Chapter 11. Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3 -- Chapter 12. The SF3b Complex Is an Integral Component of the Spliceosome and Targeted by Natural Product-based Inhibitors -- Chapter 13. Interaction Networks of Ribosomal Expansion Segments in Kinetoplastids -- Chapter 14. Hepatitis B Core Protein Capsids -- Chapter 15. Fibrinogen and Fibrin -- Chapter 16. Structural Organization and Protein-protein Interactions in Human Adenovirus Capsid -- Chapter 17. A Structural Perspective on Gene Repression by Polycomb Repressive Complex 2 -- Chapter 18. Assembly and Function of the Anthrax Toxin Protein Translocation Complex.
    Abstract: This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License vialink.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 577 p. 166 illus., 157 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030589714
    Series Statement: Subcellular Biochemistry, 96
    DDC: 572.6
    Language: English
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  • 25
    Keywords: Plant ecology. ; Soil science. ; Conservation biology. ; Ecology . ; Agriculture. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Plant Ecology. ; Soil Science. ; Conservation Biology. ; Agriculture. ; Environmental Engineering/Biotechnology.
    Description / Table of Contents: Foreword -- Preface -- Chemical fertilizers and their impact on soil health -- Microbial Bioremediation of Pesticides/Herbicides in Soil -- Pollution cleaning up techniques -- Role of Mushrooms in the Bioremediation of Soil -- Microbial degradation of organic constituents for sustainable development -- Traditional farming practices and its consequences -- Soil organic matter and its impact on soil properties and nutrient status -- Sustainable Agricultural Practices -- Values of Composting -- Introduction to Microbiota and Biofertilizers -- Fungi and their potential as Biofertilizers -- Bacillus thuringiensis as a Biofertilizer and Plant Growth Promoter -- Cyanobacteria as Sustainable Microbiome for Agricultural Industries -- Intercropping: A Substitute but Identical of Biofertilizers -- Application of Phyllosphere Microbiota as Biofertilizers -- Biofertilizers: A Viable tool for future organic agriculture -- Index.
    Abstract: The dependence of present farming on artificial input of “chemical fertilizers” has caused numerous ecological tribulations associated with global warming and soil contamination. Moreover, there is an essential requirement for realistic agricultural practices on a comprehensive level. Accordingly, biofertilizers including microbes have been recommended as feasible environmentally sound solutions for agricultural practices which not only are natural, and cost-effective but also preserve soil environs and important biota of agricultural land. In addition, it enhances the nutrient quantity of soils organically. Microbial biofertilizers promote plant growth by escalating proficient absorption of nutrients for the plants and by providing an excellent disease-fighting mechanism. Agriculture, the backbone of human sustenance, has been put under tremendous pressure by the ever-increasing human population. Although various modern agro-techniques boosted agricultural production, the excessive use of synthetic fertilizers, pesticides and herbicides have proven extremely detrimental to agriculture as well as to the environment in which it is carried out. Besides this some faulty agricultural practices like monoculture and defective irrigation, further complicate the scenario by eliminating biodiversity, increasing the efflux of nutrients into the water bodies, the formation of algal blooms, eutrophication, damaging the water quality and lowering fish stocks. Biofertilizers are the organic compounds applied to crops for their sustainable growth and the sustainability of the environment as the microbiota associated with biofertilizers interact with the soil, roots and seeds to enhance soil fertility. Application of biofertilizers results in the increased mineral and water uptake, root development, vegetative growth and nitrogen fixation besides liberating growth-promoting substances and minerals that help the maintenance of soil fertility. They further act as antagonists and play a pivotal role in neutralising soil-borne plant pathogens and thus, help in the bio-control of diseases. Application of biofertilizers instead of synthetic fertilizers could be a promising technique to raise agricultural productivity without degrading environmental quality. The present book focuses on the latest research approaches and updates from the microbiota and their applications in the agriculture industry. We believe this book addresses various challenges and shed lights on the possible future of the sustainable agricultural system.
    Type of Medium: Online Resource
    Pages: XXVII, 350 p. 174 illus., 167 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030610104
    DDC: 581.7
    Language: English
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  • 26
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Ecology . ; Botany. ; Physical geography. ; Conservation biology. ; Ecology. ; Plant Science. ; Earth System Sciences. ; Conservation Biology.
    Description / Table of Contents: PRELIMINARY (ToC of second edition) 1 Plant ecology at high elevations -- The concept of limitation -- A regional and historical account -- The challenge of alpine plant research -- 2 The alpine life zone -- Altitudinal boundaries -- Global alpine land area -- Alpine plant diversity -- Origin of alpine floras -- Alpine growth forms -- 3 Alpine climate -- Which alpine climate -- Common features of alpine climates -- Regional features of alpine climates -- 4 The climate plants experience -- Interactions of relief, wind and sun -- How alpine plants influence their climate -- The geographic variation of alpine climate -- 5 Life under snow: protection and limitation -- Temperatures under snow -- Solar radiation under snow -- Gas concentrations under snow -- Plant responses to snowpack -- 6 Alpine soils -- Physics of alpine soil formation -- The organic compound -- The interaction of organic and inorganic compounds -- 7 Alpine treelines -- About trees and lines -- Current altitudinal positions of climatic treelines -- Treeline-climate relationships -- Intrazonal variations and pantropical plateauing of alpine treelines -- Treelines in the past -- Attempts at a functional explanation of treelines -- A hypothesis for treeline formation -- Growth trends near treelines -- Evidence for sink limitation -- 8 Climatic stress -- Survival of low temperature extremes -- Avoidance and tolerance of low temperature extremes -- Heat stress in alpine plants -- Ultraviolet radiation — a stress factor -- 9 Water relations -- Ecosystem water balance -- Soil moisture at high altitudes -- Plant water relations — a brief review of principles -- Water relations of alpine plants -- Desiccation stress -- Water relations of special plant types -- 10 Mineral nutrition -- Soil nutrients -- The nutrient status of alpine plants -- Nutrient cycling and nutrient budgets -- Nitrogen fixation -- Mycorrhiza -- Responses of vegetation to variable nutrient supply -- 11 Uptake and loss of carbon -- Photosynthetic capacity of alpine plants -- Photosynthetic responses to the environment -- Daily carbon gain of leaves -- The seasonal carbon gain of leaves -- C4 and CAM photosynthesis at high altitudes -- Tissue respiration of alpine plants -- Ecosystem carbon balance -- 12 Carbon investments -- Non-structural carbohydrates -- Lipids and energy content -- Carbon costs of leaves and roots -- Whole plant carbon allocation -- 13 Growth dynamics and phenology -- Seasonal growth -- Diurnal leaf extension -- Rates of plant dry matter accumulation -- Functional duration of leaves and roots -- 14 Cell division and tissue formation -- Cell size and plant size -- Mitosis and the cell cycle -- From meristem activity to growth control -- 15 Plant biomass production -- The structure of alpine plant canopies -- Primary productivity of alpine vegetation -- Plant dry matter pools -- Biomass losses through herbivores -- 16 Plant reproduction -- Flowering and pollination -- Seed development and seed size -- Germination -- Alpine seed banks and natural recruitment -- Clonal propagation -- Alpine plant age -- Community processes -- 17 Global change at high elevation -- Alpine land use -- The impact of altered atmospheric chemistry -- Climatic change and alpine ecosystems -- References (with chapter annotation) -- Taxonomic index (genera) -- Geographical index -- Color plates -- Plant life forms -- The alpine life zone -- Environmental stress -- The human dimension.
    Abstract: This book is a completely revised, substantially extended treatment of the physical and biological factors that drive life in high mountains. The book covers the characteristics of alpine plant life, alpine climate and soils, life under snow, stress tolerance, treeline ecology, plant water, carbon, and nutrient relations, plant growth and productivity, developmental processes, and two largely novel chapters on alpine plant reproduction and global change biology. The book explains why the topography driven exposure of plants to dramatic micro-climatic gradients over very short distances causes alpine biodiversity to be particularly robust against climatic change. Geographically, this book draws on examples from all parts of the world, including the tropics. This book is complemented with novel evidence and insight that emerged over the last 17 years of alpine plant research. The number of figures – mostly in color – nearly doubled, with many photographs providing a vivid impression of alpine plant life worldwide. Christian Körner was born in 1949 in Austria, received his academic education at the University of Innsbruck, and was full professor of Botany at the University of Basel from 1989 to 2014. As emeritus Professor he is continuing alpine plant research in the Swiss Alps.
    Type of Medium: Online Resource
    Pages: XIX, 500 p. 319 illus., 283 illus. in color. , online resource.
    Edition: 3rd ed. 2021.
    ISBN: 9783030595388
    DDC: 577
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Regenerative medicine. ; Biomedical engineering. ; Biomaterials. ; Biotechnology. ; Engineering design. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Engineering and Bioengineering. ; Biomaterials. ; Biotechnology. ; Engineering Design.
    Description / Table of Contents: Metallic and Ceramic Biomaterials: Current and Future Developments -- Polymers, Composites and Nano Biomaterials: Current and Future Developments -- Polyurethane Based Materials with Applications in Medical Devices -- Rapid Prototyping of Hydrogels to Guide Tissue Formation -- Engineered Scaffold Architecture Influences Soft Tissue Regeneration -- Customized Implants for Bone Replacement and Growth -- Direct Digital Manufacturing of Complex Dental Prostheses -- Digital Design and Fabrication in Dentistry -- The Development of an Artificial Finger Joint -- Computer-Aided Development of Mega Endo-Prostheses -- Smart Insoles -- Medical Applications of Additive Manufacturing -- Additive Manufacturing in Craniofacial Applications -- Additive Manufacturing in Hearing Aids.
    Abstract: This second edition maintains a focus on integrated biomaterials, computer-aided design, and physical prototyping techniques as examples of the materials and applications that are found in medical environments. All original chapters, written by renowned experts in the field, have been updated along with the addition of four new chapters on: Smart insoles Medical applications of additive manufacturing Additive manufacturing in craniofacial applications Additive manufacturing in hearing aids This wide-ranging treatise on biomaterials and prototyping applications in medicine also focuses on solid freeform fabrication, rapid prototyping, layered manufacturing, and computer-aided design in the development of prosthetic devices. This book is a must-have for bioengineers seeking a comprehensive overview of this important subject and examples of medical applications, as well as researchers and academics in the same field. .
    Type of Medium: Online Resource
    Pages: XII, 200 p. 104 illus., 60 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030358761
    DDC: 612.028
    Language: English
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  • 28
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Parasitology. ; Veterinary microbiology. ; Evolution (Biology). ; Biology Technique. ; Parasitology. ; Veterinary Microbiology. ; Evolutionary Theory. ; Experimental Organisms.
    Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: The zoonotic dog roundworm Toxocaracanis, a worldwide burden of public health -- Chapter 3: Canine leishmaniasis -- Chapter 4: The Challenges with Canine Giardia -- Chapter 5: Dogs and their role in the eco-epidemiology of Chagas disease -- Chapter 6: Echinococcus species – tiny tapeworms -- Chapter 7: An update on the status of hydatidosis/echinococcosis in domestic animals, wildlife and humans in Australia -- Chapter 8: Dipylidiumcaninum -- Chapter 9: Ancylostoma caninum and other canine hookworms -- Chapter 10: Strongyloidiasis - really a zoonosis? -- Chapter 11: Dirofilaria spp. Do they get under your skin (or into your heart)? -- Chapter 12: Guinea worm infection in dogs: a case of reverse zoonosis that impedes Dracunculusmedinensiseradication -- Chapter 13: Ticks, dogs and humans – an endangered community -- Chapter 14: Trematodes attacking dogs and humans.
    Abstract: This book presents the latest information on canine parasites with zoonotic potential, to help avoid human infections. Compiled by international specialists, it covers protozoa, ectoparasites and helminth species of clinical importance in dogs, as well as the state of the art in diagnosis, preventive measures and potentially necessary treatment schemes. Dogs are commonly kept in families around the world and can predispose their human companions to disease. Updating and deepening insights from other specialist literature, the book is intended for practitioners and scientists alike. It also offers practical guidance for veterinary and human physicians and highlights unexplored research areas, making it a valuable resource for students and educated non-experts with an interest in parasitology, infectiology and zoonotic pet diseases.
    Type of Medium: Online Resource
    Pages: IX, 291 p. 83 illus., 80 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030532307
    Series Statement: Parasitology Research Monographs, 13
    DDC: 571.999
    Language: English
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  • 29
    Keywords: Botany. ; Forestry. ; Botanical chemistry. ; Biotic communities. ; Plant genetics. ; Plant physiology. ; Plant Science. ; Forestry. ; Plant Biochemistry. ; Ecosystems. ; Plant Genetics. ; Plant Physiology.
    Description / Table of Contents: 1.Tools Shape Paradigms of Plant-Environment Interactions -- 2.Gene Expression in Coffee -- 3. Cross-Talk Between Sporophyte and Gametophyte During Anther and Ovule Development In Angiosperms -- 4. The Photosynthetic System in Tropical Plants Under High Irradiance and Temperature Stress -- 5. Plant Peroxisomes and Their Metabolism of ROS, RNS, and RSS -- 6. Ammonium Assimilation and Metabolism in Rice -- 7. How can we Interpret the Large Number and Diversity of Abscisic Acid Transporters? -- 8. Orient in the World with a Single Eye: The Green Algal Eyespot and Phototaxis -- 9. Bidirectional Lateral Transport Barriers in Serving Plant Organs and Integral Plant Functioning: Localized Lignification, Suberinization, and Cutinization -- 10. The Haustorium of Phytopathogenic Fungi: A Short Overview of a Specialized Cell of Obligate Biotrophic Plant Parasites -- 11. Transmission of Phloem-Limited Viruses in the Host Plants by Their Aphid Vectors -- 12. Biotechnology for Biofuel Production -- 13. Modelling Urban Tree Growth and Ecosystem Services: Review and Perspectives.
    Abstract: With one volume each year, this series keeps scientists and advanced students informed of the latest developments and results in all areas of the plant sciences. This latest volume includes reviews on plant physiology, biochemistry, genetics and genomics, forests, and ecosystems.
    Type of Medium: Online Resource
    Pages: XII, 464 p. 76 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030686208
    Series Statement: Progress in Botany, 82
    DDC: 580
    Language: English
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  • 30
    Keywords: Ecology . ; Botany. ; Zoology. ; Conservation biology. ; Ecology. ; Plant Science. ; Zoology. ; Conservation Biology.
    Description / Table of Contents: Part 1: Historical and biogeographical aspects -- The Atlantic Forest: an introduction to the megadiverse forest of Southern America -- The Atlantic Forest Ecological History: from pre-history to the Anthropocene -- The North-eastern Atlantic Forest: biogeographical, historical and current aspects in the Sugarcane Zone -- The Hileia Baiana - an assessment of natural and historical aspects of the land use and degradation of the central corridor of the Brazilian Atlantic Forest -- The southern Atlantic Forest: Use, degradation, and perspectives for conservation -- Part II – Biodiversity -- Tree diversity in the Brazilian Atlantic Forest: biases and general patterns using different sources of information -- Vascular Epiphytes of the Atlantic Forest: diversity and community ecology -- Social Insects of the Atlantic Forest -- Tetrapod diversity in the Atlantic Forest: maps and gaps -- Freshwater Studies in Atlantic Forest: general overview and prospects -- Part III – Threats -- Land-cover changes and an uncertain future: will the Brazilian Atlantic Forest lose the chance to become a hopespot? -- Climate change and biodiversity in the Atlantic Forest: best climatic models, predicted changes and impacts, and adaptation options -- Non-native species introductions, invasions, and biotic homogenization in the Atlantic Forest -- Causes and consequences of large-scale defaunation in the Atlantic forest -- Pollination systems in the Atlantic Forest: characterization, threats, and opportunities -- IV - Opportunities -- Atlantic Forest: ecosystem services linking people and biodiversity -- Changing the agriculture paradigm in the Brazilian Atlantic Forest: the importance of agroforestry -- Engaging people for large-scale forest restoration: Governance lessons from the Atlantic Forest of Brazil -- The Atlantic Forest Trail: connecting people, biodiversity and protected areas -- Conservation initiatives in the Brazilian Atlantic forest -- Financing conservation in the Brazilian Atlantic Forest -- Integrating researchers for understanding the biodiversity in Atlantic Forest -- The future of the Atlantic Forest.
    Abstract: The Atlantic Forest is one of the 36 hotspots for biodiversity conservation worldwide. It is a unique, large biome (more than 3000 km in latitude; 2500 in longitude), marked by high biodiversity, high degree of endemic species and, at the same time, extremely threatened. Approximately 70% of the Brazilian population lives in the area of this biome, which makes the conflict between biodiversity conservation and the sustainability of the human population a relevant issue. This book aims to cover: 1) the historical characterization and geographic variation of the biome; 2) the distribution of the diversity of some relevant taxa; 3) the main threats to biodiversity, and 4) possible opportunities to ensure the biodiversity conservation, and the economic and social sustainability. Also, it is hoped that this book can be useful for those involved in the development of public policies aimed at the conservation of this important global biome.
    Type of Medium: Online Resource
    Pages: XXX, 517 p. 66 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030553227
    DDC: 577
    Language: English
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  • 31
    Keywords: Botany. ; Plant genetics. ; Physiology. ; Plant Science. ; Plant Genetics. ; Physiology.
    Description / Table of Contents: Artificial Small RNAs for Functional Genomics in Plants -- Use of mRNA-interactome capture for generating novel insights into plant RNA biology -- Improving nutrient value of crops: Applications of RNAi in targeting plant metabolic pathways -- Utilizing RNA-based approaches to understand plant-insect interactions.
    Abstract: This book offers a unique and comprehensive overview of key RNA-based technologies, as well as their development and applications for the functional genomics of plant coding and non-coding genes. It focuses on the latest as well as classical RNA-based techniques used for studies on small RNAs, long non-coding RNAs and protein-coding genes. These techniques chiefly focus on target mimics (TMs) and short tandem target mimics (STTMs) for small RNAs, and artificial microRNAs (amiRNAs), RNA interference (RNAi) and CRISPR/Cas for genes. Furthermore, the book discusses the latest trends in the field and various modifications of the above-mentioned approaches, and explores how these RNA-based technologies have been developed, applied and validated as essential technologies in plant functional genomics. RNA-based technologies, their mechanisms of action, their advantages and disadvantages, and insights into the further development and applications of these technologies in plants are discussed. These techniques will enable the users to functionally characterize genes and small RNAs through silencing, overexpression and editing. Gathering contributions by globally respected experts, the book will appeal to students, teachers and scientists in academia and industry who are interested in horticulture, genetics, pathology, entomology, physiology, molecular genetics and breeding, in vitro culture & genetic engineering, and functional genomics. .
    Type of Medium: Online Resource
    Pages: XIII, 428 p. 48 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030649944
    Series Statement: Concepts and Strategies in Plant Sciences,
    DDC: 580
    Language: English
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  • 32
    Keywords: Biomedical engineering. ; Signal processing. ; Medical informatics. ; Radiology. ; Biomedical Engineering and Bioengineering. ; Signal, Speech and Image Processing . ; Health Informatics. ; Radiology. ; Biomedical Devices and Instrumentation.
    Description / Table of Contents: Chapter 1. Multi-CLASS fNIRS Classification of Motor Execution Tasks with Application to Brain Computer Interfaces -- Chapter 2. A Comparative Study of End-to-End Discriminative Deep Learning Models for Knee Joint Kinematic Time Series Classification -- Chapter 3. Nonlinear Smoothing of Data with Random Gaps and Outliers (DRAGO) Improves Estimation of Circadian Rhythm -- Chapter 4. Wearable Smart Garment Devices for Passive Biomedical Monitoring -- Chapter 5. Spatial Distribution of Seismocardiographic Signals -- Chapter 6. Noninvasive Vascular Blood Sound Monitoring Through Flexible Pvdf Microphone -- Chapter 7. Fast Automatic Artifact Annotator for EEG Signals Using Deep Learning -- Chapter 8. Objective evaluation metrics for automatic classification of EEG events.
    Abstract: This book provides an interdisciplinary look at emerging trends in signal processing and biomedicine found at the intersection of healthcare, engineering, and computer science. It examines the vital role signal processing plays in enabling a new generation of technology based on big data, and looks at applications ranging from medical electronics to data mining of electronic medical records. Topics covered include analysis of medical images, machine learning, biomedical nanosensors, wireless technologies, and instrumentation and electrical stimulation. Biomedical Signal Processing: Innovation and Applications presents tutorials and examples of successful applications, and will appeal to a wide range of professionals, researchers, and students interested in applications of signal processing, medicine, and biology. ·Presents an interdisciplinary look at research trends in signal processing and biomedicine; ·Promotes collaboration between healthcare practitioners and signal processing researchers; ·Includes tutorials and examples of successful applications.
    Type of Medium: Online Resource
    Pages: VIII, 261 p. 144 illus., 109 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030674946
    DDC: 610.28
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Epidemiology. ; Population genetics. ; Epidemiology. ; Population Genetics.
    Description / Table of Contents: Review of size estimation methods -- Methods to estimate the average social network size -- Estimating the size of hidden groups -- Data smoothing, extrapolation, and triangulation.
    Abstract: This book describes the variety of direct and indirect population size estimation (PSE) methods available along with their strengths and weaknesses. Direct estimation methods, such as enumeration and mapping, involve contact with members of hard-to-reach groups. Indirect methods have practical appeal because they require no contact with members of hard-to-reach groups. One indirect method in particular, network scale-up (NSU), has several strengths over other PSE methods: It can be applied at a province/country level, it can estimate size of several hard-to-reach population in a single study, and it is implemented with members of the general population rather than members of hard-to-reach groups. The book discusses methods to collect, analyze, and adjust results and presents methods to triangulate and finalize PSEs.
    Type of Medium: Online Resource
    Pages: VII, 72 p. 3 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030754648
    Series Statement: Advances in Experimental Medicine and Biology, 1333
    DDC: 614.4
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Nutrition   . ; Plant ecology. ; Soil science. ; Refuse and refuse disposal. ; Agriculture. ; Nutrition. ; Plant Ecology. ; Soil Science. ; Waste Management/Waste Technology.
    Description / Table of Contents: Chapter 1. Organic cultivation of vegetables -- Chapter 2. Reducing arsenic accumulation in rice using advances in physiology genetics and breeding -- Chapter 3. Speciation analysis of trace antimony in environmental and biological samples based on cloud point extraction and spectrometric methods -- Chapter 4. Groundwater status and challenges in Bangladesh -- Chapter 5. Influence of organic amendments on soil properties, microflora and plant growth -- Chapter 6. Basics of waste management and disposal practices in the Indian context -- Chapter 7. Impact of the invasive Prosopis juliflora on terrestrial ecosystems -- Chapter 8. Perennial forage grass production on the marginal Arabian Peninsula land -- Chapter 9. Agricultural sustainability and food security in agro-ecological zones of Tanzania -- Chapter 10. Soil degradation, resilience, restoration and sustainable use -- Chapter 11. Integrated weed management for sustainable agriculture -- Chapter 12. Electrical impedance spectroscopy in plant biology: theory, modeling and data processing -- Chapter 13. Non-symbiotic bacteria for soil nitrogen fortification -- Chapter 14. Nutritional and medical benefits of Moringa Oleifera, the miracle tree.
    Abstract: This book presents advanced knowledge and techniques to improve food quality, such as organic farming, fertilization using waste, reducing arsenic in food, soil restoration, forage production in arid regions and weed control. Agriculture is actually facing two major challenges, feeding an ever-growing population and providing safe food in the context of pollution, climate change and the future circular economy.
    Type of Medium: Online Resource
    Pages: VII, 460 p. 53 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030732455
    Series Statement: Sustainable Agriculture Reviews, 52
    DDC: 630
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology Technique. ; Medicine Research. ; Biology Research. ; Cancer. ; Radiology. ; Oncology. ; Cytological Techniques. ; Biomedical Research. ; Cancer Biology. ; Radiology. ; Oncology.
    Description / Table of Contents: 1. Current and Futuristic Roadmap of Ovarian Cancer Management: An Overview -- 2. Epithelial ovarian cancer and cancer stem cells -- 3. Ovarian Cancer: Therapeutic Strategies to Overcome Immune Suppression -- 4. Pharmacological effects of natural components against ovarian cancer and mechanisms -- 5. Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity -- 6. PAX8, an emerging player in Ovarian Cancer -- 7. Single Cell RNA Sequencing of Ovarian Cancer: Promises and Challenges.-8. Enforced expression of METCAM/MUC18 decreases in vitro motility and invasiveness and tumorigenesis and in vivo tumorigenesis of human ovarian cancer BG-1 cells -- 9. 3D Models for Ovarian Cancer -- 10. Ovarian Cancer Stem Cells: Characterization and Role in Tumorigenesis.
    Abstract: The present book on Molecular & Diagnostic Imaging and Treatment Strategies of ovarian cancer is one of two companion books with the second one being focused on Cell and Molecular Biology of Ovarian Cancer. Both books include new exciting aspects of ovarian cancer research with chapters written by experts in their respective fields who contributed their unique expertise in specific ovarian cancer research areas and include cell and molecular details that are important for the specific subtopics. Comprehensive and concise reviews are included of key topics in the field.
    Type of Medium: Online Resource
    Pages: VIII, 178 p. 43 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030733599
    Series Statement: Advances in Experimental Medicine and Biology, 1330
    DDC: 571.6028
    Language: English
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  • 36
    Keywords: Nervous system Surgery. ; Radiology. ; Biophysics. ; Nervous system Radiography. ; Neurology . ; Neurosciences. ; Neurosurgery. ; Radiology. ; Biophysics. ; Neuroradiology. ; Neurology. ; Neuroscience.
    Description / Table of Contents: Foreword -- Preface -- Introduction -- 1. Physics and radiation dosage issues in neuroradiosurgical treatment of meningiomas -- 2. Imaging Approaches for radiosurgical treatment of Meningiomas -- 3. MEDICAL MANAGEMENT OF MENINGIOMAS -- 4. Systemic Treatments for Grade II and III Meningiomas (WHO) -- 5. Gamma Knife Radiosurgery for Posterior Cranial Fossa Meningioma -- 6. Stereotactic Radiosurgery for Cavernous Sinus Meningiomas -- 7. Hypofractionated radiosurgery for perioptic meningiomas: Current practice, principles and treatment quandary -- 8. Hypofractionation and normofractionation in Skull Base Meningiomas -- 9. Atypical and anaplastic meningiomas: is there a role for stereotactic radiosurgery? -- 10. CyberKnife Treatment of Atypical Meningiomas (GII) -- 11. SRS & Microsurgery: antagonistic or complementary in the treatment of meningiomas? -- 12. Combined microsurgical and radiosurgical treatment in intracranial meningiomas -- 13. SRS in Incidental Meningioma: Whether to Treat and When -- 14. Side-effects of SRS treatment of low-grade meningioma: types, frequency and management -- 15. Single- and Multiple-Session Radiosurgery for Spinal Meningioma: Radiosurgery for spinal meningioma -- 16. Guidelines and evidence-based recommendations for the radiosurgical treatment of CNS meningiomas.
    Abstract: Meningiomas are the most frequently reported neuro-oncologic condition, accounting for 12% to 30% of all primary intracranial tumors. The first case of intracranial meningioma treated with stereotactic radiosurgery was reported by Backlund E-O in 1971. Since then, more than 200,000 meningiomas have been treated with stereotactic radiosurgery worldwide to date. The large number of patients treated using this method is due to the fact that meningiomas are frequently located in critical areas and microsurgery is often associated with severe and permanent neurological complications. This book discusses the advantages, risks and limits of stereotactic radiosurgery relating to all regions of interest for a neuroradiosurgical approach for the treatment of central nervous system meningiomas. Firstly, it presents an introduction focusing on the “state of the art”. It then discusses the physics, imaging, neurological and neuro-oncological issues in multidisciplinary management. Lastly, it features a summary of results, including the most recent published papers regarding all the locations involved in the stereotactic radiosurgery treatment as well as new approaches to meningiomas, with particular reference to the hypofrationated treatments. Intended for anyone involved in the neuroradiosurgical treatment of brain diseases, the book provides an up-to-date overview of the latest stereotactic radiosurgery treatment of central nervous system meningiomas.
    Type of Medium: Online Resource
    Pages: X, 160 p. 30 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030794194
    DDC: 617.48
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Ecology . ; Water. ; Hydrology. ; Plant Science. ; Ecology. ; Water. ; Water. ; Water.
    Description / Table of Contents: History of freshwater red algae; taxonomic diversity and phylogeny; biogeographic trends; how to collect freshwater red algae; scope and organization of this book -- Subphylum Cyanidiophytina: Class Cyanidiophyceae; Subphylum Proteorhodophytina: Classes Compsopogonophyceae, Porphyridiophyceae, Rhodellophyceae and Stylonematophyceae -- Subphylum Eurhodophytina: Classes Bangiophyceae and Florideophyceae (Subclasses Corallinophycidae, Hildenbrandiophycidae and Rhodymeniophycidae) -- Subphylum Eurhodophytina: Class Florideophyceae, Subclass Nemaliophycidae, Orders Acrochaetiales, Balbianiales and Thoreales -- Subphylum Eurhodophytina: Class Florideophyceae, Subclass Nemaliophycidae, Order Batrachospermales.
    Abstract: This book presents the phylogeny, taxonomy and biogeography of freshwater red algae. Its content is divided into five chapters. The first chapter provides a brief history of freshwater red algal research, habits and collecting methods, general biogeographic trends and an overview of the taxonomic/phylogenetic placement of freshwater taxa. The other four chapters are taxonomic treatments of non-marine red algae based on taxonomic levels, i.e. classes within the phylum Rhodophyta, orders within each class, families within each order, and genera within each family. Descriptions, phylogenetic data (including numerous trees), geographic range (maps for most species) and dichotomous keys for identification are presented. Comprehensive data are provided for more than 220 species.
    Type of Medium: Online Resource
    Pages: XII, 338 p. 113 illus., 112 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030839703
    DDC: 580
    Language: English
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  • 38
    Keywords: Nervous system Surgery. ; Neurology . ; Radiology. ; Neurosurgery. ; Neurology. ; Radiology.
    Description / Table of Contents: Evidence on Mechanical Thrombectomy in Acute Ischemic Stroke -- In Vitro Clot Modeling and Clinical Applications -- Approaches to Mechanical Thrombectomy in Children with Arterial Ischemic Stroke -- ELVO in Urban Areas: Evolution of Stroke Systems of Care -- Surviving Large Vessel Occlusions in Uruguay: Current Challenges and Solutions -- Direct to Angiography—An Emerging Paradigm in Large Vessel Occlusion Stroke: Rationale, Feasibility, and Preliminary Results -- Thrombectomy Techniques: Stent Retriever - Balloon Guide -- Direct Aspiration thrombectomy for acute stroke: Evolution of technique and evidence -- The Stentriever-Mediated Aspiration Thrombectomy (SMAT) Technique -- Transradial Approach for Stroke -- Thrombectomy Techniques: Remote Aspiration -- Endovascular Therapy for Middle Cerebral Artery Occlusions -- Thrombectomy for Basilar Occlusion: Approach and Strategy -- Carotid Terminus Occlusion -- Thrombectomy for Acute Occlusion in Intermediate-Sized Distal Arteries -- The Tandem Occlusion -- Acute Stroke Thrombectomy and Emergent Management of Tandem Cervical Dissections -- Acute Stroke Following Carotid Endarterectomy: Approach and Strategy -- Large vessel occlusion with underlying atherosclerosis: approach and strategy -- Large Vessel Occlusion with Low NIHSS: Approach and Strategy -- Challenges in Thrombectomy: Mega Clots -- Challenges in thrombectomy: Access Problems, Hard Clots, Relapsing Occlusions and Embolizaton to New Territories -- Challenges in Thrombectomy: Impossible Aortic Arches and Tortuous Vessels.
    Abstract: This comprehensive, case-based resource provides the state-of-the-art knowledge that can help readers improve access and optimize delivery of stroke thrombectomy. Improving access to stroke is of particular importance because patients often misinterpret their symptoms or cannot speak for themselves if they have aphasia. More importantly, access needs to be organized because stroke therapies are all extremely time-sensitive. Scalable, choreographed protocols are necessary for emergency medical systems to ‘capture’ stroke patients and automatically transport and triage to time-sensitive treatments. Many of the chapters in the first section on Fundamentals and Systems provide valuable insight in improving access to stroke care. Replete with illustrative case studies and emphasizing that treatment approaches to stroke should not be comprised of a one-size-fits-all approach, this illuminating title provides the complete thought, detail, insight and organization that will help readers meet the needs of stroke patients with large vessel occlusions. 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management examines the primary technical principles that underlie the current thrombectomy approaches. Instead of continuing the conceptual dichotomy of stent vs. aspiration, many of the chapters look at underlying principles and then discuss ways in which the currently available devices and approaches can best exploit them. The variety, creativity and detail in many of these chapters will help the reader develop a deeper understanding that might assist their ability to successfully take care of their next patient that ‘doesn’t follow the textbook.’ In addition, the anatomic and pathophysiologic classification of the core Twelve Chapters will help readers organize their thinking and approach. This knowledge, particularly because it is organized based on common, challenging syndromes, will arm the reader to quickly recognize patterns and deftly adapt their management approaches to the needs of the patient. An invaluable contribution to the clinical literature, 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management will be of great interest to not only neurosurgeons and neurologists but other specialists, primary care providers, and trainees as well. .
    Type of Medium: Online Resource
    Pages: XVII, 337 p. 115 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030568573
    DDC: 617.48
    Language: English
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  • 39
    Keywords: Agriculture. ; Human geography. ; Cultural geography. ; Anthropology. ; Demography. ; Population. ; Archaeology. ; Agriculture. ; Social and Cultural Geography. ; Anthropology. ; Population and Demography. ; Archaeology.
    Description / Table of Contents: Chapter1. Historical Demography -- Chapter2. Agricultural Landforms -- Chapter3. Cultural Plant Geography -- Chapter4. Human Environmental Impacts -- Chapter5. Indigenous Agro-Ecology -- Chapter6. Tropical Agriculture -- Chapter7. Livestock and Landscape -- Chapter 8. Synthetic Contributions -- Chapter9. By Way of Background: A Biographical Sketch of William M. Denevan -- Chapter10. Being a Student of Bill Denevan -- Chapter 11. Bill Denevan - An Appreciation -- .
    Abstract: This volume aims to present the essential work of geographer and historical ecologist William M. Denevan to explain the impact and influence his thinking had on the conceptual advancement not only in his own discipline, but in a range of related disciplines such as anthropology, archaeology, and environmental history. The book is organized around eight themes, demonstrating Denevan’s early and profound insights on topics that remain of current relevance today, and the scholarly impact his writing had on subsequent scholarship. The book is unique because it offers commentary from active scholars who address the impacts of Prof. Denevan's thinking and work on contemporary environmental and ecological issues, with a focus on several groundbreaking themes (e.g. historical demography, agricultural landforms, cultural plant geography, human environmental impacts, indigenous agro-ecology, tropical agriculture, livestock and landscape, and synthetic contributions). This book will be of interest to a range of scholars in geography, anthropology, archaeology, history, and ecology, as well as to environmental managers and practitioners, especially those working for non-profit organizations and government organizations tasked with finding ways to adapt to global environmental change. .
    Type of Medium: Online Resource
    Pages: XXII, 451 p. 62 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030424800
    DDC: 630
    Language: English
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    Keywords: Biotechnology. ; Bioinformatics. ; Medical genetics. ; Biotechnology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1: Global Alignment of PPI Networks -- Chapter 2: Integrated Network-Based Computational Analysis for Drug Development -- Chapter 3: Effective Random Walk Models for Comparative Network Analysis -- Chapter 4: Computational Methods for Protein-Protein Interaction Network Alignment -- Chapter 5: Network Propagation for the Analysis of Multi_Omics Data -- Chapter 6: Motifs in Biological Networks -- Chapter 7: Bio Fabric Visualization of Network Alignments -- Chapter 8: Module Identification of Biological Networks via Graph Partition -- Chapter 9: Network Module Detection to Decipher the Heterogeneity of Cancer Mutations.
    Abstract: This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights. .
    Type of Medium: Online Resource
    Pages: XII, 217 p. 42 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571733
    DDC: 660.6
    Language: English
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  • 41
    Keywords: Neurosciences. ; Neurology . ; Medical genetics. ; Neuroscience. ; Neurology. ; Medical Genetics.
    Description / Table of Contents: 1. Behavioural variant FTD: recent advances in the diagnosis and understanding of the disorder -- 2. The neuropsychiatry of frontotemporal dementia -- 3. Nosology and Neuropathology of Language in Primary Progressive Aphasia -- 4. Measuring Behavior and Cognition in FTLD -- 5. Clinical update on C9orf72: FTD, ALS and beyond -- 6. Clinical aspects of familial FTLD associated with MAPT and GRN mutations -- 7. Neuroimaging in Frontotemporal Lobar Degeneration -- 8. The FTD Prevention Initiative - linking together genetic FTD cohort studies -- 9. Fluid Biomarkers of Frontotemporal Lobar Degeneration -- 10. Cross-cultural perspectives on frontotemporal degeneration -- 11. Clinical characteristics and Neuropathology of PSP, CBD and Related 4R-Tauopathies -- 12. Tau protein and frontotemporal dementias -- 13. FTLD-TDP pathological subtypes: clinical and mechanistic significance -- 14. Lysosomal dysfunction as a pathogenic mechanism in FTD: Evidence from PGRN and TMEM106B genetics and biology -- 15. Future trends in understanding the pathological role of TDP-43 and FUS proteins -- 16. Description of a new data resource for FTD including multiomic data on human post mortem brain (MAPT, GRN, C9orf72), matching mouse models and iPS models -- 17. Mendelian and sporadic FTD: avenues from genetics to disease pathways through in-silico prediction and modeling -- 18. FTLD treatment: Current Practice and Future Possibilities.
    Abstract: Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.
    Type of Medium: Online Resource
    Pages: X, 320 p. 46 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030511401
    Series Statement: Advances in Experimental Medicine and Biology, 1281
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food science. ; Plant biotechnology. ; Consumer behavior. ; Food Science. ; Plant Biotechnology. ; Consumer Behavior .
    Description / Table of Contents: 1. Cereals in the Mediterranean: breeding history -- 2. The evolution of milling processing -- 3. Wheat bread in the Mediterranean area: from past to the future -- 4. Italian pasta: conventional and innovative ingredients and processing -- 5. From tradition to innovation in cereal-derived foodstuffs -- 6. Blending pulses with cereals for healthier foods -- 7. Snacking: ingredients, processing and safety -- 8. Rice: a versatile food at the heart of the Mediterranean diet -- 9. The Bright and Dark Sides of Wheat -- 10. Gluten-free breadmaking: facts, issues and future -- 11. The holy grail of ancient cereals -- 12. Safety of traditional cereals foodstuff. .
    Abstract: Cereal-Based Foodstuffs: The Backbone of the Mediterranean provides an overview of cereal-based products in the Mediterranean region, illustrating the spectrum of products from past to present and their various processing methods. The text explores new and understudied market trends in cereal-based products, such as cereal-pulse blends, pulse pastas, and flat breads. Chapters cover products originating in North Africa, such as bulgur and couscous, which are consumed worldwide but underrepresented in the scientific literature. Contributing authors also offer a legislative perspective on issues of food safety, the European Food Safety Association’s definition of “novel foods,” and the position of traditional foods in the Mediterranean food industry. This wide-ranging text thus serves members of both the scientific and industrial community seeking better coverage of global cereal product trends.
    Type of Medium: Online Resource
    Pages: VIII, 339 p. 100 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030692285
    DDC: 641.3
    Language: English
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  • 43
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Immunology. ; Rheumatology. ; Diseases. ; Hematology. ; Oncology. ; Primary care (Medicine). ; Immunology. ; Rheumatology. ; Diseases. ; Hematology. ; Oncology. ; Primary Care Medicine.
    Description / Table of Contents: Chapter 1. Overview of Immunodeficiency -- Part I. B-Lymphocyte Immunodeficiency -- Chapter 2. Common Variable Immunodeficiency, Hypogammaglobulinemia, and Specific Antibody Deficiency -- Chapter 3. Agammaglobulinemia -- Chapter 4. Class Switch Defects -- Chapter 5. Transient Immunodeficiency of Infancy -- Chapter 6. Selective Isotype Immunodeficiency -- Chapter 7. Common Variable Immunodeficiency Disorders-like Disorders -- Part II. T-Cell Immunodeficiency -- Chapter 8. Severe Combined Immunodeficiency -- Chapter 9. Idiopathic CD4 Lymphopenia -- Chapter 10. Hyper IgE Syndrome -- Chapter 11. Genetic Syndromes with Associated Immunodeficiencies -- Part III. Immune Dysregulation Syndromes -- Chapter 12. Autoimmune Lymphoproliferative Syndrome -- Chapter 13. Auto-inflammatory Syndromes -- Chapter 14. Immune Dysregulation Leading to Autoimmunity -- Chapter 15. Dendritic Cells in Primary Immunodeficiency -- Part IV. Innate Immune Defects -- Chapter 16. Congenital Neutropenia and Migration Defects -- Chapter 17. Chronic Granulomatous Disease -- Chapter 18. Primary Immunodeficiencies of Complement -- Chapter 19. Natural Killer Cell Defects -- Chapter 20. Mucocutaneous Candidiasis -- Part V. Secondary Immunodeficiency -- Chapter 21. Immunodeficiency Secondary to Malignancies and Biologics -- Chapter 22. Immunodeficiency Secondary to Prematurity, Pregnancy, and Aging -- Chapter 23. Vaccinations in Primary and Secondary Immunodeficiencies Including Asplenia.
    Abstract: This book provides a broad clinical overview of primary and secondary immunodeficiencies nested in clinical cases that will help the reader understand the approach to evaluation, diagnosis, and management of these challenging cases. Chapters begin with a comprehensive overview of immunodeficiencies to ground the reader in practical knowledge of the field and these complex conditions. Chapters cover B lymphocyte immunodeficiency, T cell immunodeficiency, immune dysregulation syndromes, and innate immune defects. They discuss a range of treatment options including gene therapy or bone marrow transplant. The book continues with a discussion on secondary immunodeficiencies and their treatment. Each chapter was written by authors with expertise related to different immunodeficiency disorders and provide a succinct overview of pathomechanisms, diagnosis, and treatment of a specific condition. Primary and Secondary Immunodeficiency will be an excellent resource for practicing allergists, hematologists, clinical immunologists, fellows, residents, and other clinicians who work with immunodeficiency patients.
    Type of Medium: Online Resource
    Pages: XI, 417 p. 34 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571573
    DDC: 571.96
    Language: English
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    Keywords: Medical sciences. ; Pollution. ; Environmental chemistry. ; Refuse and refuse disposal. ; Health Sciences. ; Pollution. ; Environmental Chemistry. ; Waste Management/Waste Technology.
    Description / Table of Contents: Preface -- Chapter 1 Emerging Contaminants: Analysis, Aquatic Compartments and Water Pollution -- Chapter 2 Occurrence, Fate and Associated Risks of Organic Micropollutants included in the Watch List in the European Groundwater Bodies -- Chapter 3 Emergence of Pathogenic Fungi Resistant to Triazole Antifungal Drugs. A Threat from the Environment- Chapter 4 The Fate of Antibiotic-Resistant Bacteria in the Environment -- Chapter 5 Relationship Between Outdoor Ambient Air Pollution and Cardiovascular Disorders: A Narrative Review -- Index.
    Abstract: Emerging contaminants are chemical and biological agents for which there is growing concern about their potential health and environmental effects. The threat lies in the fact that the sources, fate and toxicology of most of these compounds have not yet been studied. Emerging contaminants, therefore, include a large number of both recently discovered and well-known compounds such as rare earth elements, viruses, bacteria, nanomaterials, microplastics, pharmaceuticals, endocrine disruptors, hormones, personal care products, cosmetics, pesticides, surfactants and industrial chemicals. Emerging contaminants have been found in many daily products, and some of them accumulate in the food chain. Correlations have been observed between aquatic pollution by emerging contaminants and discharges from wastewater treatment plants. Most actual remediation methods are not effective at removing emerging contaminants. This first volume presents comprehensive knowledge on emerging contaminants with a focus on analysis, toxicity, antibiotic resistance and human health.
    Type of Medium: Online Resource
    Pages: XVI, 308 p. 54 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030690793
    Series Statement: Environmental Chemistry for a Sustainable World, 65
    DDC: 610
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Plant anatomy. ; Plants Evolution. ; Plant ecology. ; Plant physiology. ; Plants Reproduction. ; Computational and Systems Biology. ; Plant Anatomy and Morphology. ; Plant Evolution. ; Plant Ecology. ; Plant Physiology. ; Plant Reproduction.
    Description / Table of Contents: Preface -- Acknowledgements -- Introduction: Collecting, Observing, and Describing the Natural World -- Scientific Ferment in late Eighteenth Century Edinburgh -- Scientific Exploration During Voyages of Discovery -- ... the plants of Scotland might be equally useful -- Travels in the Interior Districts of Africa -- A good practical Botanist -- So remote a country as New Holland -- The Crew labouring under the Same disorder -- Mungo Park's Last Journey -- A Tedious and Uncomfortable Passage -- Prodrommus, Florae Novae Hollndiae -- Banks's Librarian -- Taking leave of Sir Joseph Banks -- Pollen Grains of Clarkis pulchella -- Epilogue: The greatest of Banksian botanist-librarians -- Bibliography.
    Abstract: Explorer-naturalists Robert Brown and Mungo Park played a pivotal role in the development of natural history and exploration in the late eighteenth and early nineteenth centuries. This work is a fresh examination of the lives and careers of Brown and Park and their impact on natural history and exploration. Brown and Park were part of a group of intrepid naturalists who brought back some of the flora and fauna they encountered, drawings of what they observed, and most importantly, their ideas. The educated public back home was able to gain an understanding of the diversity in nature. This eventually led to the development of new ways of regarding the natural world and the eventual development of a coherent theory of organic evolution. This book considers these naturalists, Brown, Park, and their contemporaries, from the perspective of the Scottish Enlightenment. Brown’s investigations in natural history created a fertile environment for breakthroughs in taxonomy, cytology, and eventually evolution. Brown’s pioneering work in plant taxonomy allowed biologists to look at the animal and plant kingdoms differently. Park’s adventures stimulated significant discoveries in exploration. Brown and Park’s adventures formed a bridge to such journeys as Charles Darwin’s voyage on H.M.S. Beagle, which led to a revolution in biology and full explication of the theory of evolution.
    Type of Medium: Online Resource
    Pages: XIX, 217 p. 39 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030748593
    Series Statement: Memoirs of The New York Botanical Garden, 122
    DDC: 570.285
    Language: English
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    Keywords: Agricultural biotechnology. ; Agriculture Economic aspects. ; Plant diseases. ; Stress (Physiology). ; Plants. ; Plant biotechnology. ; Agricultural Biotechnology. ; Agricultural Economics. ; Plant Pathology. ; Plant Stress Responses. ; Plant Biotechnology.
    Description / Table of Contents: Introduction -- The role of selenium in human nutrition -- Methods for determination of selenium in foodstuffs -- Selenium uptake by selected vegetable species after fortification of the growing substrate.-Selenium uptake by selected vegetable species after foliar application -- Changes of selenium content in edibilities during the processing.
    Abstract: Selenium plays a significant role in preventing certain types of cancer and cardiovascular diseases. The level of Selenium in the human body depends on its concentration in food. In turn, the content in vegetable crops is a function of the soil-plant system. There are many countries in the world with low Selenium content in the soil. The average daily human intake is thus limited through food chain. Analysis of Selenium status suggests that fortification of the soil substrate with Sodium Selenate, and foliar application to agricultural crops are both effective means of Selenium enrichment. Our intention for this publication is to present the possibilities of augmenting Selenium content by biofortification of soils and plants through differentiated nutrition. In the first part of the monograph, the results of Selenium supplementation in model vegetation experiments are presented. The next part of the monograph presents the results of foliar supplementation of Selenium in field conditions. This book is an outstanding reference source for plant breeders and researchers engaged in biofortification of horticulture crops. It is also beneficial to agricultural companies and other stakeholders.
    Type of Medium: Online Resource
    Pages: XIV, 155 p. 29 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030704865
    DDC: 630
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Nutrition   . ; Food science. ; Chemistry, Organic. ; Biomedical Research. ; Nutrition. ; Food Science. ; Organic Chemistry.
    Description / Table of Contents: Part I: An overview of cancer and its mechanisms -- 1-A brief overview of cancer, its mechanisms, and prevention methods -- 2-MECHANISMS INVOLVED IN CARCINOGENESIS -- Part II: Functional foods/nutraceuticals as chemo preventive agents -- 3-Tomato (lycopene and β-carotene) and cancer -- 4-Essential Oils from Aromatic Plants in cancer prevention and treatment -- 5-Bee propolis (caffeic acid phenethyl ester) against cancer -- 6-Brown Algae (Fucoxanthin) Against Cancer -- 7-Cruciferous vegetables (indole-3-carbinol, isothiocyanates) against cancer -- 8-Crustacea (carotenoids namely astaxanthins) against cancer -- 9-Curcuma and breast cancer: a focus on cell signaling pathways -- 10-FRUITS AND VEGETABLES IN CANCER -- 11-Garlic: Allyl Sulfur Compounds and Cancer Prevention -- 12-Ginger (gingerols and 6-shogaol) against cancer -- 13-Saffron (crocins) against cancer -- 14-OLIVE LEAF (OLEUROPEIN) AND ITS ROLE IN CANCER: THERAPEUTIC UPDATES -- 15-Honey against cancer -- 16-Soybeans and phytoestrogen rich foods (genistein, daidzein) against cancer -- 17-Tea (catechins including (-)-epigallocatechin-3-gallate) and cancer -- 18-Probiotics and Cancer -- Part III: The role of nutrients in the prevention of cancer -- 19-Vitamins (C, D and E) against cancer -- 20-Minerals (namely selenium) and cancer -- 21-Dietary fibers/beta-glucan and cancer -- 22-Omega-3 Polyunsaturated Fatty Acids and Cancer.
    Abstract: Today's consumers are looking for food products with health-promoting roles in addition to nutritional benefits. With current research showing that nutraceuticals and functional foods rich in specific bioactives may have chemopreventative effects, these products are increasingly popular. However, while much in the literature supports the health-promoting features of these foods, few texts focus on their bioactive agents and their mode of action in cancer signaling. Nutraceuticals and Cancer Signalling: Clinical Aspects and Mode of Action explains the link between nutraceuticals and cancer in terms of clinical trials and modes of action. This book gives an overview of common cancers and their mechanisms, and the most common functional foods and their bioactive components. Individual chapters focus on specific functional foods--including tomatoes, garlic, honey, tea, yoghurt, and many more--their prominent bioactive compounds, and their mode of action in cancer signaling and chemoprevention. Recent findings on cancer-prevention roles of different vitamins and minerals are also discussed. For food scientists, nutritionists, and pharmaceutical experts looking to understand how functional foods can play a role in fighting cancer, this text serves as a one-stop reference.
    Type of Medium: Online Resource
    Pages: IX, 652 p. 52 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030740351
    Series Statement: Food Bioactive Ingredients,
    DDC: 610.72
    Language: English
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    Keywords: Medical microbiology. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Biotechnology. ; Medical Microbiology. ; Biomedical Research. ; Pharmacology. ; Biomedical Research. ; Biotechnology.
    Description / Table of Contents: 1.Introduction to Drugs, Drug Targets and Drug Resistance -- 2.Drugs Resistance in Bacterial Diseases -- 3.Drugs Resistance Against Viral Diseases -- 4.Drug Resistance in Protozoal Infections -- 5.Antifungal Drugs: Mechanism of Action and Resistance -- 6.Drug Resistance in Ear, Nose, and Throat Infections -- 7.Drug Resistance in Skin Diseases -- 8.Drugs Resistance in Lungs Diseases -- 9.Neurological Disorders: Biochemistry of Drug Resistance and Future Challenges -- 10.Drug Resistance in Kidney Diseases -- 11.Drugs resistance in Heart Diseases -- 12.Drugs Resistance in Liver Disease -- 13.Drug Resistance in Cancer -- 14.Drugs Resistance and Treatment Failure in HIV and / or AIDS -- 15.Drug Resistance in Reproductive Diseases -- 16.Drug Resistance in Diabetes -- 17.Drug Resistance in Rheumatological Diseases -- 18.Pherotypes in Streptococcus pneumoniae and Role of CSP-1 and CSP-2 in Antibiotic Susceptibility and Resistance; Towards Development of Live Attenuated Vaccine Candidates in Inducing Netosis Based Acquired Immune Response -- 19.Hypoxia, Obesity and Drug Resistance; Towards Sustainable Development Goals and Globalization -- 20.Genetic and Molecular Mechanisms of Multidrug-resistance in Uropathogens and Novel Therapeutic Combat -- 21.Drugs Resistance Management.
    Abstract: This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included. .
    Type of Medium: Online Resource
    Pages: XI, 558 p. 97 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030763206
    DDC: 616.9041
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Parasitology. ; Proteins . ; Molecular biology. ; Cytology. ; Tropical medicine. ; Parasitology. ; Protein Biochemistry. ; Molecular Biology. ; Cell Biology. ; Tropical Medicine.
    Description / Table of Contents: Chapter 1. Introductory Chapter: The Importance of Heat Shock Proteins in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum -- Chapter 2. General Structural and Functional Features of Molecular Chaperones -- Chapter 3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum -- Chapter 4. Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum. Chapter 5. Role of Hsp90 in Plasmodium falciparum Malaria -- Chapter 6. The Role of Malaria Parasite Heat Shock Proteins in Protein Trafficking and Remodelling of Red Blood Cells -- Chapter 7. Role of Heat Shock Proteins in Immune Modulation in Malaria -- Chapter 8. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalarial Drug Discovery? -- Chapter 9. Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery -- Chapter 10 -- Heat Shock Proteins of Malaria: Highlights and Future Prospects.
    Abstract: This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer’s Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.
    Type of Medium: Online Resource
    Pages: XIII, 251 p. 26 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030783976
    Series Statement: Advances in Experimental Medicine and Biology, 1340
    DDC: 571.999
    Language: English
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  • 50
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Food science. ; Environmental sciences Social aspects. ; Botany. ; Nutrition   . ; Agriculture. ; Food Science. ; Environmental Social Sciences. ; Plant Science. ; Nutrition.
    Description / Table of Contents: Ch 1: Introduction -- Ch 2: Physical and engineering properties of the seed -- Ch 3: Breeding and world production -- Ch 4: Functional food development and products -- Ch 5: Innovations in Bambara ground nut processing -- Ch 6: Composition and nutritional profile -- Ch 7: Ingredients and novel applications -- Ch 8: Food components and consumption trends -- Ch 9: Bambara ground nut as a climate smart crop -- Ch 10: Current and innovative packaging technologies for Bambara ground nut -- Ch 11 Integrating text mining and network analysis for potential application of Bambara ground nut -- Ch 12 Digitalization of Bambara food value -- Ch 13 Ethnonutrition and ethnomedical knowledge associated with Bambara ground nut -- Ch 14 Current and future research directions -- Ch 15 Conclusion -- Ch 16 References.
    Abstract: The Bambara groundnut (BGN) or Vigna subterranea is an extremely hardy grain legume. As it produces reasonable yields even under conditions of drought and low soil fertility, it is also a climate-smart crop. Previously underutilized, BGN is the subject of growing interest among researchers and consumers for its balanced nutritional profile. Indigenous consumers of BGN report medicinal benefits from the plant; however, such knowledge is at risk of being lost with the urbanization and changing lifestyles of younger generations. To date, there is no comprehensive resource on the Bambara groundnut, despite market demand for plant proteins around the globe. Authored by scientists who have researched and developed patents using BGN, Bambara Groundnut: Utilization and Future Prospects aims to fill this gap. The text provides in-depth coverage on breeding, food and feed utilization, medicinal benefits and future research prospects. Drawing on both indigenous knowledge and cutting-edge research, Bambara Groundnut is the first book to fully explore the potential of this remarkable crop.
    Type of Medium: Online Resource
    Pages: XVIII, 238 p. 65 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030760779
    DDC: 630
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Human physiology. ; Neurosciences. ; Pharmacology. ; Human Physiology. ; Neuroscience.
    Description / Table of Contents: Comparison of K+ Channel families -- High-resolution structures of K+ channels -- Pharmacological approaches to studying potassium channels -- Cardiac K+ channels and channelopathies -- Cardiac hERG K+ channel as safety and pharmacological target -- Pharmacology of A-type K+ channels -- Kv7 channels and hyperexcitability disorders -- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain -- Potassium channels in cancer -- Kir channel molecular physiology, pharmacology and therapeutic implications -- The pharmacology of ATP-sensitive K+ channels (KATP) -- Calcium-activated K+ channels (KCa) and therapeutic implications -- The Pharmacology of two-pore domain potassium channels -- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits -- Peptide toxins targeting KV channels -- Therapeutic antibodies targeting potassium ion channels.
    Abstract: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology. .
    Type of Medium: Online Resource
    Pages: VIII, 545 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030840525
    Series Statement: Handbook of Experimental Pharmacology, 267
    DDC: 615
    Language: English
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    Keywords: Botany. ; Food science. ; Plant Science. ; Food Science.
    Description / Table of Contents: 1-Introduction to Opuntia spp.: Chemistry, bioactivity and Industrial Applications -- 2-South African perspective on Opuntia spp.: cultivation, human and livestock food and industrial applications -- 3-Ethnobotany, medicinal utilization and Systematics of Opuntia species from Deserts of Pakistan -- 4-Cactus Pear (Opuntia spp.) Species and Cultivars -- 5-Classification, Distribution and Morphological Characterization of Opuntia species -- 6-Cultivation and Cultural Practices of Opuntia spp -- 7-Molecular characterization of Opuntia spp -- 8-Genetic diversity and ecotypes of Opuntia spp -- 9-Potential attribute of crassulacean acid metabolism of Opuntia spp. production in water-limited conditions -- 10-Harvest and Postharvest Technology of Opuntia spp -- 11-Chemistry and functionality of Opuntia spp. nopal cladodes -- 12-Opuntia ficus-indica (L.) Mill. Bioactive Ingredients and Phyto-constituents -- 13-Opuntia Fiber and its Health-Related Beneficial Properties -- 14-Opuntia spp. chemical constituents and bioactive compounds, with particular regards to polyphenols -- 15-Profile and Biological Properties of the main Phenolic compounds in cactus pear (Opuntia spp.) -- 16-Opuntia spp. essential oils -- 17-Antioxidant activity of Opuntia spp.: A review -- 18-Natural antimicrobial molecules from Opuntia spp. and their role in poultry nutrition -- 19-Genus Opuntia: A golden source of compounds with anti-inflammatory potential -- 20-Opuntia spp. benefits in chronic diseases -- 21-Traceability of Opuntia spp -- 22-Antidiabetic Activity of Opuntia spp -- 23-Anticancer Activity of Opuntia spp -- 24-Innovative technologies for the identification of chemical and bioactive compounds in Opuntia spp. plant, food and waste -- 25-Innovation technologies for extracting Opuntia spp. seed oil -- 26-Novel pectins from prickly pear (Opuntia albicarpa) fruits: structural features and rheological properties -- 27-Modern Technologies in Opuntia spp. Juice Processing -- 28-Novel Technologies in Juice Processing from Opuntia spp. Fruits -- 29-Potential use of prickly pear juice prepared from shelf-grown cultivars as an authentic and nutritional fruit supplement -- 30-Fermented Beverages from Opuntia species: Composition, Commercialization and Future Outlook -- 31-Opuntia spp. Marmalade -- 32-Opuntia pear peel as a source of functional ingredients and their utilization in meat products -- 33-Opuntia spp. Seed Oil -- 34-Prickly pear (Opuntia ficus indica) processing by extrusion-cooking -- 35-Opuntia spp. and Extruded Food Products -- 36-Opuntia spp. Extruded Food Products -- 37-Industrial uses of Opuntia spp. by-products -- 38-Bread Enrichment with Opuntia spp. Derivatives -- 39-Opuntia spp. products and by-products as a potential source of edible films and coatings -- 40-Microencapsulation technology: an alternative preservation method for Opuntia spp. derived products and their bioactive compounds -- 41-Prickly pear (Opuntia spp.) in animal and poultry feed -- 42-Industrial applications of Opuntia spp. (nopal, fruit and peel) -- 43-Opuntia spp. as a source of sugars for the ethanol production -- 44-Opuntia spp. in biogas production -- 45-Opuntia spp. in dye-sensitized solar cells -- 46-Incorporation of Opuntia spp. into Food Systems -- 47-Opuntia spp. in cosmetics and pharmaceuticals -- 48-Food and non-food applications of Opuntia spp. seed oil -- 49-Opuntia spp. in the textile industry -- 50-Cactus pear as colorants and coloring foods: application in different food matrices.
    Abstract: The Opuntia fruits, commonly known as cactus pears or prickly pears, have been suggested by the Food and Agriculture Organization to be a promising and strategic crop in regions suffering from lack of water. In Mexico, India, South Africa, and the Mediterranean, the Opuntia fruits have become popular due to their nutritive value and health-promoting benefits, including antioxidant, antiulcerogenic and antiatherogenic traits and protective effects against LDL oxidation. Additionally, readily absorbable sugars, high vitamin C and mineral content, and a pleasant flavour make Opuntia tailor-made for novel food. Due to their ecological advantages, high functional value, and health-related traits, Opuntia fruits can be highly exploited in different food processing applications. For instance, Opuntia cactus fruits are used for the preparation of juices and marmalades; Opuntia cactus plants are used to feed animals in African and Latin American countries; Peruvian farmers cultivate Opuntia cactus for growing the cochineal (Dactylopius coccus) insect and producing the natural dye carmine; and the commercial production of food and non-food products from Opuntia has been established in Mexico, USA and several Mediterranean countries. Opuntia spp.: Chemistry, Bioactivity and Industrial Applications creates a multidisciplinary forum of discussion on Opuntia cactus with special emphasis on its horticulture, post-harvest, marketability, chemistry, functionality, health-promoting properties, technology and processing. The text includes detailed discussion of the impact of traditional and innovative processing on the recovery of high-added value compounds from Opuntia spp. by-products. Later chapters explore the potential applications of Opuntia spp. in food, cosmetics and pharmaceutical products.
    Type of Medium: Online Resource
    Pages: XIX, 1059 p. 98 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030784447
    DDC: 580
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food science. ; Chemistry, Organic. ; Food Science. ; Organic Chemistry.
    Description / Table of Contents: SECTION 1: CHEMISTRY OF PHENOLIC ANTIOXIDANTS -- Ch 1: Concept of Antioxidant -- Introduction to Antioxidant -- Types of antioxidants -- Mechanism of Antioxidant Reaction -- Estimation of Antioxidant Activity -- Phenolic Antioxidants -- Nomenclature of phenolic compounds -- Ch 2: Chemistry of Phenolic Antioxidants -- Classification -- Phenolic acids -- Phenolic aldehydes and alcohols -- Phenolic esters -- Cinnamic acid amides -- Lignans and lignin -- Tannins -- Coumarins -- Flavonoids -- Glycosides -- Ch 3: Phenolic Antioxidants in Foods -- Phenolic antioxidants in fruits -- Phenolic antioxidants in Vegetables -- Phenolic antioxidants in Cereals and legumes -- Phenolic antioxidants in Beverages -- Phenolic antioxidants in Edible Oil -- SECTION 2: BIOCHEMISTRY OF PHENOLIC ANTIOXIDANTS -- Ch 4: Biosynthesis of Phenolic Antioxidants -- Biosynthesis of Phenolic acids -- Biosynthesis of Phenolic aldehydes and alcohols -- Biosynthesis of Phenolic esters -- Biosynthesis of Cinnamic acid amides -- Biosynthesis of Lignans and lignin -- Biosynthesis of Tannins -- Biosynthesis of Coumarins -- Biosynthesis of Flavonoids -- Biosynthesis of Glycosides -- Ch 5: Metabolism of Phenolic Antioxidants. -- Ingestion of phenolic antioxidants -- Digestion and absorption -- Phenolic antioxidants in Bloodstream -- Interactions with Proteins -- Interactions with Carbohydrates -- Ch 6: Pharmacological Effects of Phenolic Antioxidants -- Pharmacological significance -- Oxidative stress & Phenolic antioxidants -- Aging & Phenolic antioxidants -- Health & Diseases -- Ch 7: Molecular Mechanism of Phenolic Antioxidants -- Basic Mechanism -- In-vitro studies -- In-vivo studies -- SECTION 3: ANALYSIS OF PHENOLIC ANTIOXIDANTS -- Ch 8: Basics in Analysis of Phenolic Antioxidants -- Extraction of phenolic compounds -- Spectrophotometric analysis -- Titrimetric methods -- Electrochemical methods -- Ch 9: Chromatography of Phenolic Antioxidants -- Thin layer chromatography -- Liquid chromatography -- Gas chromatography -- Ch 10: Spectroscopy of Phenolic Antioxidants -- Mass spectrometry -- Nuclear Magnetic resonance spectroscopy -- Near-infrared spectroscopy. .
    Abstract: Plant foods are an essential part of our daily diet and constitute one of the highest contributors to the world economy. These foods are rich in phenolic compounds, which play a significant role in maintaining our health. This textbook presents a comprehensive overview of the chemistry, biochemistry and analysis of phenolic compounds present in a variety of foods. The text can be used as a singular source of knowledge for plant food science and technology, covering all of the important chemical, biochemical and analytical aspects needed for a thorough understanding of phenolic antioxidants in foods. Phenolic Antioxidants In Foods: Chemistry, Biochemistry, and Analysis is comprised of three sections. The first section covers the basic concepts of antioxidants, their chemistry and their chemical composition in foods, providing a detailed introduction to the concept. The second section covers the biochemical aspects of phenolic antioxidants, including their biosynthetic pathways, biological effects and the molecular mechanism of antioxidant effects in the biological system. This section promotes an understanding of the fundamental biochemical reactions that take place in foods and after digestion and absorption. The third section covers the analytical chemistry used in the analysis of phenolic antioxidants in foods, including the basic analytical procedures, methods for analysis and chromatographic and spectroscopic analyses. This section is significant for aspiring food chemists and manufacturers to evaluate the nature and chemistry of phenolic antioxidants in foods. Featuring helpful quizzes, section summaries, and key chapter points, this textbook is the perfect learning tool for advanced chemistry undergraduates and post-graduates looking to gain a fundamental understanding of phenolic antioxidants in food products. .
    Type of Medium: Online Resource
    Pages: XIX, 556 p. 165 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030747688
    DDC: 641.3
    Language: English
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    Keywords: Botany. ; Botanical chemistry. ; Food science. ; Medicine, Preventive. ; Health promotion. ; Agriculture. ; Plant Science. ; Plant Biochemistry. ; Food Science. ; Health Promotion and Disease Prevention. ; Agriculture.
    Description / Table of Contents: 1. Acrocomia aculeata -- 2. Attalea dubia & Attalea phalerata -- 3. Campomanesia genus -- 4. Caryocar spp -- 5. Mauritia flexuosa -- 6. Dipteryx alata -- 7. Solanum lycocarpum -- 8. Attalea speciosa -- 9. Syagrus romanzoffiana -- 10. Hancornia speciosa.
    Abstract: Fruits of the Brazilian Cerrado: Composition and Functional Benefits describes the nutritional, chemical and physical characteristics of the fruits of the Cerrado, as well as their pharmacological effects and use in phytotherapics. Chapters are dedicated to the morphological characteristics, macronutrients, micronutrients and active compounds of various fruits, with separate sections covering their peels, leaves, nuts, pulps, and other components. The text also includes detailed studies on the treatment of diseases with these natural products, as well as their applications in popular use by local communities. Authors explain the importance of bioactive compounds found in the fruits and their possible mechanisms of action in the organism. This text thus provides a valuable reference to researchers studying a range of topics, including functional foods, phytotherapy, and plant science.
    Type of Medium: Online Resource
    Pages: XIII, 186 p. 31 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030629496
    DDC: 580
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Botany. ; Genetics. ; Agriculture. ; Plant Science. ; Genetics and Genomics.
    Description / Table of Contents: Abstract -- 1. Preface -- 2. Introduction -- 3. Flower morphology -- 4. Phyllotaxy and floral development -- 5. Pollen morphology -- 5.1 Pollen viability and germination -- 6. Pollination -- 6.1 Floral visitors and insect pollination -- 7. Fruit morphology -- 8. Propagation -- 8.1 Seed germination -- 8.2 Vegetative propagation -- 8.2 Cuttings -- 9. Fruit development -- 10. Fruit properties and health benefits -- 11. Breeding and hybridization -- 12. Genetic diversity -- 12.1 Chromosome number -- 13. Morphological diversity -- 14. Conclusion.
    Abstract: This work reviews and explores various aspects of uchuva growth and development from seed germination, vegetative growth and phyllotaxy, floral development, pollination, and pollen morphology through fruit development, properties and health benefits. Other sections of the book cover uchuva genetic diversity, hybridization, chromosome number and morphological diversity. Uchuva is economically important in most South American counties, has been growing in popularity in Central America, and is marketed in North American and Europe as the golden berry. This is the first concise reference work that delves into the fascinating world of uchuva reproductive biology. It includes the latest scientific references, some of which have been contributed by the authors of the current book. The authors have observed the plant in the field and have produced a unique photographic record to help the reader see the actual morphological structures and developmental processes in action.
    Type of Medium: Online Resource
    Pages: XX, 175 p. 119 illus., 109 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030665524
    DDC: 630
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant physiology. ; Plants Development. ; Botanical chemistry. ; Plant Physiology. ; Plant Development. ; Plant Biochemistry.
    Description / Table of Contents: Introduction -- Structure, Development and Patterns of Primary, Secondary and Regenerative Vascular Tissues -- The Hormonal Signals that Regulate Plant Vascular Differentiation -- Importance of NO3- and PO4- for Development, Differentiation and Competition -- Phloem and Xylem Differentiation -- Apical Dominance and Vascularization -- Leaf Development and Vascular Differentiation -- Flower Biology and Vascular Differentiation -- Can a Differentiating Vessel Induce Lateral Root Initiation? -- Vascular Regeneration and Grafting -- Regulation of Cambium Activity -- Regulation of Juvenile-Adult Transition and Rejuvenation -- The Control of Tracheid Size, Vessel Widening and Density along the Plant Axis -- Circular Vascular Tissues, Vessel Endings and Tracheids in Organ Junctions -- Ray Differentiation – the Radial Pathways -- Environmental Adaptation of Vascular Tissues -- Resin Glands and Traumatic Duct Formation in Conifers -- Hormonal Control of Reaction Wood Formation -- Hormonal Control of Wood Evolution -- How Vascular Differentiation in Hosts Is Regulated by Parasitic Plants and Gall-Inducing Insects -- Cancer and Vascular Differentiation.
    Abstract: The book is intended as a guide for molecular biology students, equipping them to successfully study plants. It pursues a holistic approach, viewing the whole plant as an integrated operating organism, and is written in a straightforward manner, making it appealing to anyone interested in plants. Further, it reflects the latest findings for scientists and students in the fields of plant sciences, biology, agriculture, forestry, ecology, vascular medicine and cancer, discussing e.g. how hormonal signals induce and regulate simple and complex patterns in plants vascular tissues, their adaptation and evolution. • written by a world-renowned expert who has worked in the field for 50 years • covers the field from the initial studies conducted more than a century ago up to recent studies with up-to-date explanations • describes in details the structure, development, physiology and basic molecular biology of plants’ vascular tissues, their function, regeneration and environmental adaptation • explores the controlling mechanisms of plant vascular differentiation by continuously moving hormonal signals and their precursors • discusses the regulation of stem cells and cambium, control of gradients in vascular cell size along the plant, juvenile-adult transition and rejuvenation, grafting, mechanisms of recovery from bending by reaction wood, evolution of vessels and fibers from tracheids, regulation of ring-porous wood evolution, protecting mechanisms against insects and pathogens, parasitism, plant cancer, and more • helps readers understand the scope and breadth of plant vascular systems in 20 detailed, high-quality chapters • includes a wealth of outstanding original color photographs and illustrations documenting the formation of vascular tissues • provides an in-depth understanding of plant biology by studying their vascular tissues.
    Type of Medium: Online Resource
    Pages: LXIII, 339 p. 135 illus., 81 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030532024
    DDC: 571.2
    Language: English
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    Keywords: Biotic communities. ; Environment. ; Ecology . ; Landscape ecology. ; Ecosystems. ; Environmental Sciences. ; Terrestial Ecology. ; Landscape Ecology. ; Ecology.
    Description / Table of Contents: Chapter 1. Introduction (Deborah C. Hayes, Becky K. Kerns, Toral Patel-Weynand, and Deborah M. Finch) -- Chapter 2. Impacts of Invasive Species in Terrestrial and Aquatic Systems in the United States (Albert E. Mayfield III, Steven J. Seybold, Wendell R. Haag, M. Tracy Johnson, Becky K. Kerns, John C. Kilgo, Daniel J. Larkin, Rima D. Lucardi, Bruce D. Moltzan, Dean E. Pearson, John D. Rothlisberger, Jeffrey D. Schardt, Michael K. Schwartz, and Michael K. Young) -- Chapter 3. Impacts of Invasive Species on Forest and Grassland Ecosystem Processes in the United States (Chelcy Ford Miniat, Jennifer M. Fraterrigo, Steven T. Brantley, Mac A. Callaham, Jr., Susan Cordell, Jeffrey S. Dukes, Christian P. Giardina, Shibu Jose, and Gary Lovett) -- Chapter 4. Effects of Climate Change on Invasive Species (Deborah M. Finch, Jack L. Butler, Justin B. Runyon, Christopher J. Fettig, Francis F. Kilkenny, Shibu Jose, Susan J. Frankel, Samuel A. Cushman, Richard C. Cobb, Jeffrey S. Dukes, Jeffrey A. Hicke, and Sybill K. Amelon) -- Chapter 5. Invasive Species Response to Natural and Anthropogenic Disturbance (Susan E. Meyer, Mac A. Callaham, Jr., Jane E. Stewart, and Steven D. Warren) -- Chapter 6. Early Intervention Strategies for Invasive Species Management: Connections Between Risk Assessment, Prevention Efforts, Eradication, and Other Rapid Responses (Robert C. Venette, Doria R. Gordon, Jennifer Juzwik, Frank H. Koch, Andrew M. Liebhold, Robert K.D. Peterson, Sharlene E. Sing, and Denys Yemshanov) -- Chapter 7. Management of Landscapes for Established Invasive Species (Therese M. Poland, Jennifer Juzwik, Allen Rowley, Cynthia D. Huebner, John C. Kilgo, Vanessa M. Lopez, Deanna H. Olson, Dean Pearson, Robert Progar, Robert Rabaglia, John D. Rothlisberger, Justin B. Runyon, and Sharlene E. Sing) -- Chapter 8. Restoration of Landscapes and Habitats Affected by Established Invasive Species (Jennifer Koch, Dean E. Pearson, Cynthia D. Huebner, Michael K. Young, and Richard A. Sniezko) -- Chapter 9. Sectoral Impacts of Invasive Species in the United States and Approaches to Management (Anne S. Marsh, Deborah C. Hayes, Patrice N. Klein, Nicole Zimmerman, Alison Dalsimer, Douglas A. Burkett, Cynthia D. Huebner, Robert Rabaglia, Laura A. Meyerson, Bonnie L. Harper-Lore, Jamie L. Davidson, Marla R. Emery, Travis Warziniack, Rebecca Flitcroft, Becky K. Kerns, and Vanessa M. Lopez) -- Chapter 10. Inventory and Monitoring of Invasive Species (Sonja Oswalt, Chris Oswalt, Alycia Crall, Robert Rabaglia, Michael Schwartz, and Becky K. Kerns) -- Chapter 11. Tools and Technologies for Quantifying Spread and Impacts of Invasive Species (Matt Reeves, Inés Ibáñez, Dana Blumenthal, Gang Chen, Qinfeng Guo, Catherine Jarnevich, Jennifer Koch, Frank Sapio, Michael K. Schwartz, Bruce K. Wylie, and Stephen Boyte) -- Chapter 12. Social and Cultural Dynamics of Non-Native Invasive Species (John Schelhas, Janice Alexander, Mark Brunson, Tommy Cabe, Alycia Crall, Michael J. Dockry, Marla R. Emery, Susan J. Frankel, Nina Hapner, Caleb R. Hickman, Rebecca Jordan, Michael J. LaVoie, Zhao Ma, Ross K. Meentemeyer, Joe Starinchak, and Jelena Vukomanovic) -- Chapter 13. The Role of International Cooperation in Invasive Species Research (Andrew Liebhold, Faith Campbell, Doria R. Gordon, Qinfeng Guo, Nathan Havill, Bradley Kinder, Richard MacKenzie, David R. Lance, Dean Pearson, Sharlene E. Sing, Travis Warziniack, Robert C. Venette, and Denys Yemshanov) -- Chapter 14. Economics of Invasive Species (Travis Warziniack, Robert G. Haight, Denys Yemshanov, Jenny L. Apriesnig, Thomas P. Holmes, Amanda M. Countryman, John D. Rothlisberger, and Christopher Haberland) -- Chapter 15. Legislation and Policy (Faith T. Campbell, Hilda Diaz-Soltero, and Deborah C. Hayes) -- Chapter 16. Future Invasive Species Research Challenges and Opportunities (Becky K. Kerns, Therese M. Poland, Robert C. Venette, Toral Patel-Weynand, Deborah M. Finch, Allen Rowley, Deborah C. Hayes, Mike Ielmini) -- APPENDIX 1: Regional Summaries.
    Abstract: This open access book describes the serious threat of invasive species to native ecosystems. Invasive species have caused and will continue to cause enormous ecological and economic damage with ever increasing world trade. This multi-disciplinary book, written by over 100 national experts, presents the latest research on a wide range of natural science and social science fields that explore the ecology, impacts, and practical tools for management of invasive species. It covers species of all taxonomic groups from insects and pathogens, to plants, vertebrates, and aquatic organisms that impact a diversity of habitats in forests, rangelands and grasslands of the United States. It is well-illustrated, provides summaries of the most important invasive species and issues impacting all regions of the country, and includes a comprehensive primary reference list for each topic. This scientific synthesis provides the cultural, economic, scientific and social context for addressing environmental challenges posed by invasive species and will be a valuable resource for scholars, policy makers, natural resource managers and practitioners.
    Type of Medium: Online Resource
    Pages: XLII, 455 p. 87 illus., 67 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030453671
    DDC: 577
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Physiology. ; Nutrition   . ; Evolution (Biology). ; Immunology. ; Internal medicine. ; Physiology. ; Nutrition. ; Evolutionary Biology. ; Immunology. ; Internal Medicine.
    Description / Table of Contents: Selection of the Fattest: The Invention of Eating -- The Gut Revolution -- The Bowels of Existence. The Intestinal Palimpsest: The Rules of Social Engagement -- The Orchestra of Life -- The Layers of Time. The Gastro-Archeologist: ‘What is Food to One is Rank Poison to Another’: food allergy and Intolerances -- The Evil bread: Coeliac disease and gluten related disorders -- Back to the very Beginning: The Inflammatory Bowel Diseases.
    Abstract: In order to understand common conditions such as coeliac disease and Crohn’s disease, one must view the gut in its evolutionary context. This is the novel approach to the gut and its diseases that is adopted in this book. The first part tells the story of the evolution of the gut itself – why it came about and how it has influenced the evolution of animals ever since. The second part focuses on the evolution of immunity and how the layers of immune mechanisms are retained in the gut, resembling the strata revealed in an archeological dig. The final part, ‘The Gastro-Archeologist’, ties the first two together and highlights how understanding the gut and immune system in their evolutionary context can help us understand diseases affecting them. Ambitious in its scope but telling a unique story from a refreshingly novel perspective, the book offers an informative and enjoyable read. As the story of the gut, immunity and disease unfolds, the author aims to endow readers with the same sense of awe and excitement that the subject evokes in him. Difficult concepts are illustrated using simple and colourful analogies, and the main content is supplemented with anecdotes and unusual and amusing facts throughout the book. The book is intended for anyone with an interest in the gut, its immunity and diseases, ranging from school and college biology and biomedical students, to professionals working in the field, and to patients suffering from intestinal diseases who want to understand more about their conditions.
    Type of Medium: Online Resource
    Pages: XVII, 304 p. 46 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030626211
    DDC: 571
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Cancer. ; Microtechnology. ; Microelectromechanical systems. ; Biomedical engineering. ; Biotechnology. ; Cancer Biology. ; Microsystems and MEMS. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Part 1 -- Conventional nanosized drug delivery systems for cancer applications -- Homing peptides for cancer therapy -- Radiolabeling of theranostic nanosystems -- Boosting nanomedicine efficacy with hyperbaric oxygen therapy -- Part 2 -- Mesoporous Silica Nanoparticles as Carriers for Biomolecules in Cancer Therapy -- Clearable Nanoparticles for Cancer Photothermal Therapy -- Biohybrid Nanosystems for Cancer Treatment: Merging the Best of Two Worlds -- Electrospun Nanofibers for Cancer Therapy -- Nanoneedle-based materials for intracellular studies -- Part 3 -- In vitro assays for nanoparticle-cancer cell interaction studies -- 3D tumor spheroid models for in vitro therapeutic screening of nanoparticles -- In vitro and in vivo tumor models for the evaluation of anticancer nanoparticles -- Part 4 -- Nanotechnology for the Development of Nanovaccines in Cancer Immunotherapy -- Viral nanoparticles: cancer vaccines and immune modulators -- Industrial Perspective on Cancer Immunotherapy -- Index.
    Abstract: The book covers the latest developments in biologically-inspired and derived nanomedicine for cancer therapy. The purpose of the book is to illustrate the significance of naturally-mimicking systems for enhancing the dose delivered to the tumor, to improve stability, and prolong the circulation time. Moreover, readers are presented with advanced materials such as adjuvants for immunostimulation in cancer vaccines. The book also provides a comprehensive overview of the current status of academic research. This is an ideal book for students, researchers, and professors working in nanotechnology, cancer, targeted drug delivery, controlled drug release, materials science, and biomaterials as well as companies developing cancer immunotherapy.
    Type of Medium: Online Resource
    Pages: VIII, 360 p. 80 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030581749
    Series Statement: Advances in Experimental Medicine and Biology, 1295
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: History of the Quinoas in South America -- Botanical context for domestication in South America -- Botanical context for domestication in North America -- Quinoa Cytogenetics -- A chromosome-scale quinoa reference genome assembly -- Structural and Functional Genomics of Chenopodium quinoa -- Quinoa diversity and its implications for breeding -- Saponins of Quinoa: Structure, Function and Opportunities -- Abiotic stress tolerance in quinoa -- Flowering in Chenopodium and related amaranths -- Quinoa – Evolution and future perspectives.
    Abstract: This book focuses on quinoa, providing background information on its history, summarizing recent genetic and genomic advances, and offering directions for future research. Meeting the caloric and nutritional demands of our growing population will not only require increases in overall food production, but also the development of new crops that can be grown sustainably in agricultural environments that are increasingly susceptible to degradation. Quinoa is an ancient crop native to the Andean region of South America that has recently gained international attention because its seeds are high in protein, particularly in essential amino acids. Quinoa is also highly tolerant of abiotic stresses, including drought, frost and salinity. For these reasons, quinoa has the potential to help address issues of food security – a potential that was recognized when the United Nations declared 2013 the International Year of Quinoa. However, more effort is needed to improve quinoa agronomically and to understand the mechanisms of its abiotic stress tolerance; the recent development of genetic and genomic tools, including a reference genome sequence, will now help accelerate research in these areas.
    Type of Medium: Online Resource
    Pages: XVII, 195 p. 43 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030652371
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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    Keywords: Biotic communities. ; Environmental monitoring. ; Environmental management. ; Environmental chemistry. ; Pollution. ; Ecosystems. ; Environmental Monitoring. ; Environmental Management. ; Environmental Chemistry. ; Pollution.
    Description / Table of Contents: Part I. Soil and Sediment Contaminants, Risk Assessment and Remediation -- Chapter 1. Introduction to Part I: Soil and Sediment Contaminants, Risk Assessment and Remediation -- Chapter 2. Combating Arsenic Pollution in Soil Environment via Alternate Agricultural Land Use -- Chapter 3. Temporal and Seasonal Variation in Leachate Pollution Index (LPI) in Sanitary Landfill Sites- A Case study of Baidyabati landfill, West Bengal, India -- Chapter 4.Quantification of Landfill Gas Emission and Energy Recovery Potential: A Comparative Assessment of LandGEM and MTM Model for Kolkata -- Chapter 5. Assessment of natural enrichment of heavy minerals along coastal placers of India: Role of lake and river mouth embayment and its implications -- Chapter 6. Assessment the Impact of Plastic Contaminated Fertilizers on Agricultural Soil Health: A Case Study in Memari II C.D.Block, Purba Bardhaman,West Bengal, India -- Chapter 7. Determining the Role of Leaf Relative Water Content and Soil Cation Exchange Capacity in Phytoextraction Process – Using Regression Modelling -- Chapter 8. Phytoremediation of Arsenic using Allium sativum as Model System -- Chapter 9. Spatio-temporal analysis of open waste dumping sites using Google Earth: A case study of Kharagpur City, India -- Part II. Water Contaminants, Risk Assessment and Remediation -- Chapter 10. Introduction to Part II: Water Contaminants, Risk Assessment and Remediation -- Chapter 11. Groundwater Arsenic Contamination Zone based on geospatial modeling, risk and remediation -- Chapter 12. Geospatial assessment of surface water pollution and industrial activities in Ibadan, Nigeria -- Chapter 13. Aquaculture-based water quality assessment and risk remediationalong the Rasulpur River belt, West Bengal -- Chapter 14. Heavy Metal Contamination in Groundwater and Impact on Plant and Human -- Chapter 15. Emerging Threats of Microplastic contaminant in freshwater environment -- Chapter 16. Exploring Particle Size Transport Variability of Suspended Sediments in two Alpine Catchments over the Lesser Himalayan Region, India -- Chapter 17. Salinity and corrosion potential of groundwater in Mewat district of Haryana, India -- Chapter 18. Threats to quality in the coasts of the Black Sea: heavy metal pollution of seawater, sediment, macro-algae and sea-grass -- Chapter 19. Geospatial assessment of groundwater quality for drinking through Water Quality Index and Human Health Risk Index in an upland area of Chotanagpur Plateau of West Bengal, India -- Chapter 20. Existence of Pharmaceuticals and Personal Care Products (PPCPs) in the conventional water treatment process -- Chapter 21. Arsenic-rich surface and groundwater around eastern parts of Rupnagar district, Punjab, India -- Part III. Environmental Contaminants, Impacts and Sustainable Management -- Chapter 22. Introduction to Part III: Environmental Contaminants, Risk Assessment and Remediation -- Chapter 23. Dynamics of ultra-fine particles in indoor and outdoor environments: a modelling approach to study the evolution of particle characteristics -- Chapter 24. Environmental impacts of coal-mining and coal-fired power-plant activities in a developing country with global context -- Chapter 25. Overview of Indoor air pollution: A human health perspective -- Chapter 26. Mineralogy and Morphological characterization of Technogenic Magnetic Particles (TMP) from industrial dust: Insights into environmental implications -- Chapter 27. Pesticides: Recent Updates on Types Toxicity and Bioremediation Strategies -- Chapter 28. Commonly available plant neem (Azadirachtaindica A. Juss) ameliorates dimethoate induced toxicity in climbing perch Anabas testudineus -- Chapter 29. Estimating Particulate Matter concentrations from MODIS AOD considering meteorological parameters using Random Forest Algorithm -- Chapter 30 Bio-monitoring and bioremediation of a trans-boundary river in India: Functional roles of benthic mollusks and fungi -- Chapter 31 Assessing the Maximum Aerobic Biodegradation Potential of Leaf Litter, an Organic Fraction of Municipal Solid Waste, Under Optimum Nutrient Conditions -- Chapter 32. Rising trend of air pollution and its decadal consequences on meteorology and thermal comfort over Gangetic West Bengal, India.
    Abstract: This book demonstrates the measurement, monitoring and mapping of environmental contaminants in soil & sediment, surface & groundwater and atmosphere. This book explores state-of-art techniques based on methodological and modeling in modern geospatial techniques specifically focusing on the recent trends in data mining techniques and robust modeling. It also presents modifications of and improvements to existing control technologies for remediation of environmental contaminants. In addition, it includes three separate sections on contaminants, risk assessment and remediation of different existing and emerging pollutants. It covers major topics such as: Radioactive Wastes, Solid and Hazardous Wastes, Heavy Metal Contaminants, Arsenic Contaminants, Microplastic Pollution, Microbiology of Soil and Sediments, Soil Salinity and Sodicity, Aquatic Ecotoxicity Assessment, Fluoride Contamination, Hydrochemistry, Geochemistry, Indoor Pollution and Human Health aspects. The content of this book will be of interest to researchers, professionals, and policymakers whose work involves environmental contaminants and related solutions.
    Type of Medium: Online Resource
    Pages: XX, 720 p. 225 illus., 185 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030634223
    Series Statement: Environmental Challenges and Solutions,
    DDC: 577
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Biotechnology. ; Regenerative medicine. ; Cytology. ; Human Physiology. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Cell Biology.
    Description / Table of Contents: Section 1: Introduction of Acellularization -- Section 2: Extra Cellular Matrix (ECM) as a Bioscaffold -- Section 3: Methods of Characterization of Acellularized Tissue -- Section 4: Methods of Sterilization of Acellularized Tissue -- Section 5: skin -- Chapter 1: Thin Skin -- Chapter 2: Thick Skin -- Section 6: Cartilage Tissue -- Chapter 1: Hyaline cartilage -- Chapter 2: Fibrocartilage -- Chapter 3: Elastic cartilage -- Section 7: Bone Tissue -- Section 8: Cardiovascular System -- Section 9: Digestive System I -- Chapter 1: Tongue -- Chapter 2: Esophagus -- Chapter 3: Stomach -- Chapter 4: Small Intestine -- Chapter 5: Large Intestine -- Section 10: Digestive System II -- Chapter 1: Liver -- Chapter 2: Pancreases -- Chapter 3: Gallbladder -- Section 11: Respiratory System -- Chapter 1: Trachea -- Chapter 2: Lung -- Section 12: Urinary System -- Chapter 1: Kidney -- Chapter 2: Bladder -- Section 13: Nerve System -- Chapter 1: Central Nerve System (CNS) -- Chapter 2: Peripheral Nerve System (PNS) -- Section 14: Female Reproductive System -- Chapter 1: Ovary -- Chapter 2: Uterus -- Chapter 3: Vagina -- Chapter 4: Cervix -- Section 15: Male Reproductive System -- Chapter 1: Prostate Gland -- Chapter 2: Testis.
    Abstract: This contributed volume is the first of a series that introduces safe, feasible, and practical decellularization and recellularization techniques for tissue and organ reconstruction. We have put special emphasis on the research areas most likely to develop well-engineered scaffolds for tissue and organ engineering, while presenting easily applicable bench-to-bedside approaches highlighting the latest technical innovations in the field. This book includes both a fundamental discussion for a broad understanding of the basis of tissue repair and substitution, as well as chapters written by world renowned specialists from 20 countries providing deeper discussions and analysis of related sub disciplines. Within these pages, the reader will find state-of-the-art protocols and current clinical challenges in cell and tissue biology, including accurate and comprehensive information on extracellular matrices, natural biomaterials, tissue dynamics, morphogenesis, stem cells, cellular fate progressions, cell and tissue properties for in-vitro and in-vivo applications. This comprehensive and carefully organized treatise provides a clear framework for graduate students and postdoctoral researchers new to the field, but also for researchers and practitioners looking to expand their knowledge on tissue and organ reconstruction.
    Type of Medium: Online Resource
    Pages: XIII, 259 p. 63 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030827359
    Series Statement: Advances in Experimental Medicine and Biology, 1345
    DDC: 612
    Language: English
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  • 63
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Immunology. ; Human physiology. ; Medicine Research. ; Biology Research. ; Respiratory organs Diseases. ; Immunology. ; Human Physiology. ; Biomedical Research. ; Pneumology.
    Description / Table of Contents: 1. Can GPCRs be targeted to control inflammation in asthma? -- 2. Cellular and molecular processes in pulmonary hypertension -- 3. INFLAMMATORY PATHWAYS IN SARCOIDOSIS -- 4. Innate Immune Responses and Pulmonary Diseases -- 5. Interstitial Lung Disease associated with Connective Tissue Diseases -- 6. Molecular mechanisms of vascular damage during lung injury -- 7. Neurotrophin Regulation and Signaling in Airway Smooth Muscle -- 8. Novel Thoracic MRI approaches for the assessment of pulmonary physiology and inflammation -- 9. Overview on Interactive Role of Inflammation, Reactive Oxygen Species and Calcium signaling in Asthma, COPD and Pulmonary Hypertension -- 10. Protein S-palmitoylation and lung diseases -- 11. Redox role of ROS and inflammation in pulmonary diseases -- 12. Semaphorin3E/PlexinD1 axis in asthma: what we know so far -- 13. Serine protease inhibitors to treat lung inflammatory diseases -- 14. Sex and Gender Differences in Lung Disease -- 15. Sex hormones and lung inflammation -- 16. Synopsis of Clinical Acute Respiratory Distress Syndrome (ARDS).
    Abstract: Lung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.
    Type of Medium: Online Resource
    Pages: XVI, 384 p. 42 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030687489
    Series Statement: Advances in Experimental Medicine and Biology, 1304
    DDC: 571.96
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Diseases. ; Genetics. ; Immunology. ; Biomedical Research. ; Diseases. ; Genetics and Genomics. ; Immunology.
    Description / Table of Contents: Ch 1: Overview of Microbial NGS -- Ch 2: WGS for Bacterial Identification and Susceptibility Testing -- Ch 3: WGS for Bacterial Virulence Assessment -- Ch 4: Epidemiological Typing by WGS -- Ch 5: Bioinformatics Approaches for WGS Analysis -- Ch 6: WGS for Clinical Virology -- Ch 7: WGS for Clinical Mycology -- Ch 8: WGS for Clinical Parasitology -- Ch 9: Long Read Sequencing -- Ch 10: Aspects of WGS Integration -- Ch 11: Microbiome Analysis -- Ch 12: Metagenomics of Environmental Samples -- Ch 13: Clinical Metagenomics -- Ch 14: Metagenomics for Pathogen Discovery -- Ch 15: Advanced Applications for MALDI-TOF: Typing -- Ch 16: Advanced Applications for MALDI-TOF: Infectious Diseases and Antibiotic Susceptibility Testing (AST) -- Ch 17: Omics for Food and Water Microbiology -- Ch 18: Omics for Forensic and Post-Mortem Microbiology -- Ch 19: Omics for Antimicrobial Resistance Surveillance -- Ch 20: Total Laboratory Automation.
    Abstract: Various “omics” methods have recently revolutionized molecular diagnostics. Next-generation sequencing (NGS) makes it possible to sequence a human genome in just one day. Whole genome sequencing (WGS) greatly improves the ability to investigate the outbreaks of numerous pathogens. Metagenomics helps to analyze the microbiome, which aids greatly in identifying the pathogenesis of infectious diseases. Proteomic-based methods, namely matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF-MS), have a promising role in identifying myctobacteria and fungi, and predicting antimicrobial resistance. While there are numerous scientific publications on “omics” applications for microbiology, there are relatively few books that review this topic from a clinical diagnostics perspective. This book looks at this field from a holistic viewpoint, instead of limiting by type of “omics” technology, in order to cover the body of knowledge needed for practitioners and academics interested in clinical and public health microbiology. Additionally, it addresses the management, economical, regulatory and operational aspects of integrating these technologies into routine diagnostics.
    Type of Medium: Online Resource
    Pages: VI, 240 p. 17 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030621551
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Genetics. ; Biotechnology. ; Agriculture. ; Plant Science. ; Genetics and Genomics. ; Biotechnology. ; Agriculture.
    Description / Table of Contents: Chapter 1. Genome and Transcriptome of Amaranth Species -- Chapter 2. Organelle Genomics: The Chloroplast Genome of Amaranth -- Chapter 3. Genetic and Phenotypic Odyssey: Voyage of the Grain Amaranths from the Americas to the Old World -- Chapter 4. Genetics of Betalain Pigments in Amaranth Species -- Chapter 5. Molecular Characterization of Seed Storage Proteins (SSPs) in Grain Amaranth -- Chapter 6. Genetic Diversity in Amaranth and its Close Relatives -- Chapter 7. Searching for an Identity: Functional Characterization of Taxonomically Restricted Genes in Grain Amaranth -- Chapter 8. How to Overcome Recalcitrance? Novel Strategies and Recent Advances in the Genetic Transformation of Grain Amaranth -- Chapter 9. Polyploidy and Hybridization for Amaranth Crop Improvement -- Chapter 10. Amaranth Transcription Factors in Response to Biotic and Abiotic Stresses.
    Abstract: This book describes the development of genetic resources in amaranths, with a major focus on genomics, reverse, and forward genetics tools and strategies that have been developed for crop improvement. Amaranth is an ancient crop native to the New World. Interest in amaranths is being renewed, due to their adaptability, stress tolerance, and nutritional value. There are about 65 species in the genus, including Amaranthus caudatus L., A. cruentus L., and A. hypochondriacus L., which are primarily grown as protein-rich grains or pseudocereals. The genus also includes major noxious weeds (e.g., A. palmeri). The amaranths are within the Caryophyllales order and thus many species (e.g., A. tricolor) produce red (betacyanin) or yellow (betaxanthin) betalain pigments, which are chemically distinct from the anthocyanins responsible for red pigmentation in other plants. A. hypochondriacus, which shows disomic inheritance (2n = 32; n= 466 Mb), has been sequenced and annotated with 23,059 protein-coding genes. Additional members of the genus are now also been sequenced including weedy amaranths, other grain amaranths, and their putative progenitors.
    Type of Medium: Online Resource
    Pages: XVII, 181 p. 53 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030723651
    Series Statement: Compendium of Plant Genomes,
    DDC: 580
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biotechnology. ; Biomedical engineering. ; Biomedical Research. ; Biotechnology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Graviola Fruit Extraction by Ionic Liquid Microwave-assisted Extraction (IL-MAE) -- Role of Ionic Liquids in the Enzyme Stabilization: A Case Study with Trichoderma ressie Cellulase -- Role of Ionic Liquids in the Processing of Lignocellulosic Biomass -- Proliferation of rat amniotic stem cell (AFSC) on modified surface microcarrier -- Application of spectroscopic methods for the analysis of non-halal meats in food products: A narrative review -- Identification of Potential Biomarkers of Porcine Gelatin -- Gamma Ray Mutagenesis on Bacteria Isolated from Shrimp Farm Mud for Microbial Fuel Cell Enhancement and Degradation of Organic Waste -- Effect of temperature on antibacterial activity and fatty acid methyl esters of Carica papaya seed extract -- Solid-state Fermentation of Agro-industrial Waste Using Heterofermentative Lacti Acid Bacteria -- Synthesis of chitosan-folic acid nanoparticles as a drug delivery system for propolis compounds.
    Abstract: This contributed volume, “Multifaceted Protocols in Biotechnology, Volume 2”, consists of multidisciplinary methods and techniques commonly used in biotechnology studies. There are two sections covered in this book – Ionic Liquid Related Techniques & Evergreen Biotechnology Techniques. A brief introduction supports each protocol to allow easy learning and implementation. The first section consists of three chapters covering studies in modern biotechnology focusing on the role of ionic liquid techniques in extracting secondary metabolites, enzyme stabilization and biomass processing. The second section covers evergreen methodologies. It comprises five chapters covering topics on microcarrier technology for cell culture; Polymerase Chain Reaction for non-halal sources detection in food; ELISA for biomarker identification; gamma ray-induced mutagenesis for enhancing microbial fuel cells; and the effect of temperature on antibacterial activity of Carica papaya seed extract. This book will be useful to graduate students, researchers, academics, and industry practitioners working in the area of biotechnology.
    Type of Medium: Online Resource
    Pages: VII, 159 p. 45 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030755799
    DDC: 610.72
    Language: English
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    Keywords: Biotic communities. ; Forestry. ; Physical geography. ; Applied ecology. ; Ecology . ; Ecosystems. ; Forestry. ; Earth System Sciences. ; Applied Ecology. ; Terrestial Ecology.
    Description / Table of Contents: Chapter 1. Introduction to Fire Ecology across USA Forested Ecosystems: Past, Present, and Future (Cathryn H. Greenberg, Beverly S. Collins, Scott Goodrick, Michael C. Stambaugh, and Gary R. Wein) -- Chapter 2. The Role of Fire in the Dynamics of Piedmont Vegetation (Joanna Spooner, Robert K. Peet, Michael P. Schafale, Alan S. Weakley and Thomas R. Wentworth) -- Chapter 3. Fire Ecology and Fire Management of Southeastern Coastal Plain Pine Ecosystems (Jeff S. Glitzenstein, J. Stephen Brewer, Ronald. E. Masters, J. Morgan Varner, and J. Kevin Hiers) -- Chapter 4. Fire Ecology and Management in Eastern Broadleaf and Appalachian Forests (Mary A. Arthur, J. Morgan Varner, Charles W. Lafon, Heather D. Alexander, Daniel C. Dey, Craig A. Harper, Sally P. Horn, Todd F. Hutchinson, Tara L. Keyser, Marcus A. Lashley, Christopher E. Moorman, and Callie J. Schweitzer) -- Chapter 5. Fire Ecology and Management of Forest Ecosystems in the Western Central Hardwoods and Prairie-Forest Border (Michael C. Stambaugh, Benjamin O. Knapp, and Daniel C. Dey) -- Chapter 6. Fire in Floodplain Forests of the Southeastern USA hy (Paul R. Gagnon, Loretta L. Battaglia, Brice B. Hanberry, William H. Conner, and Sammy L. King) -- Chapter 7. History and Future of Fire in Hardwood and Conifer Forests of the Great Lakes-Northeastern Forest Region, USA(Lee E. Frelich, Craig G. Lorimer, and Michael C. Stambaugh) -- Chapter 8. Fire Ecology of Rocky Mountain Forests(Sharon M. Hood, Brian J. Harvey, Paula J. Fornwalt, Cameron E. Naficy, Winslow D. Hansen, Kimberley T. Davis, Mike A. Battaglia, Camille Stevens-Rumann, Victoria Saab) -- Chapter 9. Fire Ecology of the North American Mediterranean-Climate Zone(Hugh D. Safford, Ramona J. Butz, Gabrielle N. Bohlman, Michelle Coppoletta, Becky L. Estes, Shana E. Gross, Kyle E. Merriam, Marc D. Meyer, Nicole A. Molinari, and Amarina Wuenschel) -- Chapter 10. Fire Ecology and Management in Pacific Northwest Forests(Matthew J. Reilly, Jessica E. Halofsky, Meg A. Krawchuk, Daniel C. Donato, Paul F. Hessburg, James Johnston, Andrew Merschel, Mark E. Swanson, Joshua S. Halofsky, and Thomas A. Spies) -- Chapter 11. Fire Ecology and Management of Southwestern Forests(Peter Z. Fulé, Catrin M. Edgeley, Carol L. Chambers, Serra Hoagland, Blanca Céspedes) -- Chapter 12. Fire and Forests in the 21st Century: Managing Resilience under Changing Climates and Fire Regimes in USA Forests(James M. Vose, David L. Peterson, Christopher J. Fettig, Jessica E. Halofsky, J. Kevin Hiers, Robert E. Keane, Rachel Loehman, and Michael C. Stambaugh).
    Abstract: This edited volume presents original scientific research and knowledge synthesis covering the past, present, and potential future fire ecology of major US forest types, with implications for forest management in a changing climate. The editors and authors highlight broad patterns among ecoregions and forest types, as well as detailed information for individual ecoregions, for fire frequencies and severities, fire effects on tree mortality and regeneration, and levels of fire-dependency by plant and animal communities. The foreword addresses emerging ecological and fire management challenges for forests, in relation to sustainable development goals as highlighted in recent government reports. An introductory chapter highlights patterns of variation in frequencies, severities, scales, and spatial patterns of fire across ecoregions and among forested ecosystems across the US in relation to climate, fuels, topography and soils, ignition sources (lightning or anthropogenic), and vegetation. Separate chapters by respected experts delve into the fire ecology of major forest types within US ecoregions, with a focus on the level of plant and animal fire-dependency, and the role of fire in maintaining forest composition and structure. The regional chapters also include discussion of historic natural (lightning-ignited) and anthropogenic (Native American; settlers) fire regimes, current fire regimes as influenced by recent decades of fire suppression and land use history, and fire management in relation to ecosystem integrity and restoration, wildfire threat, and climate change. The summary chapter combines the major points of each chapter, in a synthesis of US-wide fire ecology and forest management into the future. This book provides current, organized, readily accessible information for the conservation community, land managers, scientists, students and educators, and others interested in how fire behaviour and effects on structure and composition differ among ecoregions and forest types, and what that means for forest management today and in the future. .
    Type of Medium: Online Resource
    Pages: XVII, 502 p. 71 illus., 65 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030732677
    Series Statement: Managing Forest Ecosystems, 39
    DDC: 577
    Language: English
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    Keywords: Otorhinolaryngology. ; Neurosciences. ; Otorhinolaryngology. ; Neuroscience.
    Description / Table of Contents: Ch 1: Binaural Processing of Sounds -- Ch 2: Localization and Lateralization of Sound -- Ch 3: Sound Source Localization Is a Multisystem Process -- Ch 4: Anatomy and Physiology of the Avian Binaural System -- Ch 5: Binaural Hearing by the Mammalian Auditory Brainstem: Joint Coding of Interaural Level and Time Differences by the Lateral Superior Olive -- Ch 6: Binaural Hearing with Temporally Complex Signals -- Ch 7: Binaural Hearing and Across-Channel Processing -- Ch 8: Binaural Unmasking and Spatial Release from Masking -- Ch 9: Spatial Hearing in Rooms and Effects of Reverberation -- Ch 10: Computational Models of Binaural Processing -- Ch 11: Clinical Ramifications of the Effects of Hearing Impairment and Aging on Spatial and Binaural Hearing -- Ch 12: Physiology of Higher Central Auditory Processing and Plasticity -- Ch 13: Binaural Hearing with Devices. .
    Abstract: This volume provides an up-to-date reference on the developments and novel ideas in the field of binaural hearing. The primary readership for the volume are specialists in the diverse fields such as psychoacoustics, neuroscience, engineering, psychology, audiology, hearing aids, and cochlear implants.
    Type of Medium: Online Resource
    Pages: XVII, 417 p. 92 illus., 74 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571009
    Series Statement: Springer Handbook of Auditory Research, 73
    DDC: 617.51
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plants Development. ; Plants Evolution. ; Plant diseases. ; Plant biotechnology. ; Plant ecology. ; Biodiversity. ; Plant Development. ; Plant Evolution. ; Plant Pathology. ; Plant Biotechnology. ; Plant Ecology. ; Biodiversity.
    Description / Table of Contents: Abstract -- Introduction -- Historical Survey -- Morphology -- Flowers -- Fruit, Seed, Dispersal and Germination -- Pollen -- Floral/Reproductive Biology and Phenology -- Chromosomes -- Chemistry -- Phylogeny and Evolution. Geographic Distribution and Ecology -- Conservation -- Systematic Treatment -- Insufficiently Known Species -- Excluded Names -- Acknowledgements -- Literature Cited -- Numerical List of Taxa -- List of Exsiccatae -- Index of Scientific Names.
    Abstract: This volume is a monograph of the genus Diplusodon (Lythraceae), written by the world authority on this plant group. Diplusodon is a monophyletic genus of shrubs and subshrubs, with showy, 6-merous, actinomorphic flowers, and floral tubes on which the sepals alternate with conspicuous epicalyx segments. The capsular fruit contains winged seeds and, uniquely for the family, is divided by a bipartite placenta with two semi-lunate septa. Diplusodon is the second largest genus in the Lythraceae and occurs mostly in the Cerrado Biome, the floristically diverse savannah that covers more than two million km2 of the Central Brazilian Plateau, extending west into Bolivia, south to Paraguay and east to the Caatinga. A total of 104 species and eight varieties are recognized in the genus, for which 46 lectotypes, one neotype, one new status and one new combination are designated, nine new species are described, and 15 taxa are placed in synonymy. New information on floral and vegetative morphology, pollen, cytology, chemistry, floral biology, and habitat are provided for the genus. In addition, keys to the species are accompanied by descriptions, illustrations, distribution maps, and assignment of conservation status.
    Type of Medium: Online Resource
    Pages: XVI, 516 p. 160 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030658755
    Series Statement: Flora Neotropica, 122
    DDC: 571.82
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Life Origin. ; Biochemistry. ; Metabolism. ; Bioinorganic chemistry. ; Protein Biochemistry. ; Origin of Life. ; Biochemistry. ; Metabolism. ; Bioinorganic Chemistry.
    Description / Table of Contents: Introduction -- Modern Fundamental Life System -- The Origin of Protein -- The Origin of Cell Structure -- The Origin of Metabolism -- The Origin of tRNA -- The Origin of the Genetic code -- The Origin of Gene -- The Origin of Life -- General Discussion.
    Abstract: The origin of life has been investigated by many researchers from various research fields, such as Geology, Geochemistry, Physics, Chemistry, Molecular Biology, Astronomy and so on. Nevertheless, the origin of life remains unsolved. One of the reasons for this could be attributed to the different approaches that researchers have used to understand the events that happened on the primitive Earth. The origins of the main three members of the fundamental life system, as gene, genetic code and protein, could be only separately understood with these approaches. Therefore, it is necessary to understand the origins of gene, the genetic code, tRNA, metabolism, cell structure and protein not separately but comprehensively under a common concept in order to understand the origin of life, because the six members are intimately related to each other. In this monograph, the author offers a comprehensive hypothesis to explain the origin of life under a common concept. At the same time, the author offers the [GADV] hypothesis contrasting it with other current hypotheses and discusses the results of analyses of genes/proteins and the experimental data available in the exploration of the current knowledge in the field. This book is of interest for science students, researchers and the general public interested in the origin of life.
    Type of Medium: Online Resource
    Pages: XXIII, 240 p. 105 illus., 76 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030710873
    DDC: 572.6
    Language: English
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    Keywords: Embryology. ; Vertebrates. ; Physiology. ; Anatomy, Comparative. ; Reproductive health. ; Veterinary medicine. ; Embryology. ; Vertebrate Zoology. ; Animal Physiology. ; Animal Anatomy. ; Reproductive Medicine. ; Veterinary Science.
    Description / Table of Contents: Mammalian Placentation: A Tribute to E.C. Amoroso’s Contributions to Placenta Development -- The Evolution of Viviparity in Vertebrates -- Development of Pre-Implantation Mammalian Blastocyst -- Placentation in Marsupials -- The Early Stages of Implantation and Placentation in the Pig -- Placentation in Equids -- Implantation and Placentation in Ruminants -- Canine Endotheliochorial Placenta - Morpho-Functional Aspects -- Placentation in The African Elephant (Loxodonta Africana) -- Development of the Mouse Placenta -- Placentation in the Human hnd Higher Primates.
    Abstract: The present volume of the book series Advances in Anatomy, Embryology and Cell Biology brings together current reviews from leading experts to address the diversity of placentation by which species establish and maintain pregnancy. Development of viviparity and placentation in rodents, dogs, pigs, cattle, horses, marsupials, primates and elephants are discussed. The development of viviparity in mammals, including some invertebrate species, required the adaptation of the placenta to serve as a functional conduit for interplay between the semiallograftic fetus with the maternal uterus. Although the ‘placenta’ protects the fetus from maternal immune rejection and provides oxygen and nutrient flow to support it to term across all the species, structural differentiation of this fetal-maternal interface can vary from simple to very complex. E.C. Amoroso contributed greatly to our early understanding and knowledge of placentation across a great variety of species. His work on placentation provides numerous illustrations and histological sections which are used for teaching and stimulating research today. With this book, we want to pay tribute to his lifetime contributions to the field by reviewing our current understanding of the development of viviparity and placentation in different species. The book is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in placentation and viviparity.
    Type of Medium: Online Resource
    Pages: XII, 254 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030773601
    Series Statement: Advances in Anatomy, Embryology and Cell Biology, 234
    DDC: 571.86
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Human physiology. ; Molecular biology. ; Pharmacology. ; Human Physiology. ; Molecular Biology.
    Description / Table of Contents: General Overview of Organic Cation Transporters in Brain -- Organic Cation Transporter Expression and Function in the CNS -- Genetic and Epigenetic Regulation of Organic Cation Transporters -- Experimental Methods for Investigating Uptake 2 Processes In Vivo -- Substrates and inhibitors of OCTs and PMAT and therapeutic implications -- Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications -- Organic Cation Transporters in Brain Catecholamine Homeostasis -- The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances -- Organic Cation Transporters in Psychiatric Disorders -- Organic Cation Transporters and Nongenomic Glucocorticoid Action -- Brain Plasma Membrane Monoamine Transporter in Health and Disease -- Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications -- Organic Cation Transporter (OCT/OCTN) Expression at Brain Barrier Sites: Focus on CNS Drug Delivery.
    Abstract: Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 328 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030829841
    Series Statement: Handbook of Experimental Pharmacology, 266
    DDC: 615
    Language: English
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  • 73
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biophysics. ; Senses and sensation. ; Nanoscience. ; Biotechnology. ; Biomedical Research. ; Sensory Systems. ; Nanophysics. ; Chemical Bioengineering.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Bioreceptors -- Chapter 3. Catalytic Biosensors -- Chapter 4. Affinity Biosensors -- Chapter 5. Affinity Biosensors -- Chapter 6. Label-free Biosensors -- Chapter 7. Bioreceptor Immobilization -- Chapter 8. Biochips. Chapter 9. Genome Sequencing -- Chapter 10. Genome Sequencing -- Chapter 11. Micro Electrode Arrays, Implants and Organs-on-a-Chip -- Appendix.
    Abstract: This textbook describes the basic principles and mechanism of action of biosensor systems, and introduces readers to the various types of biosensors; from affinity biosensors to catalytic, optical and label-free biosensors, the most common systems are explained in detail. Dedicated advanced sections focus on biochips and genome sequencing methods as well as organs-on-a-chip. The textbook helps readers to understand the elementary components of biosensors, and to identify and illustrate each function in the biosensor information flow, from recognition to transduction and transmission. Furthermore, readers will receive guidance in critically analyzing published studies on biosensor research, helping them to develop appropriate concepts and independently propose their own solutions. The textbook is intended for master’s students in bioengineering, biophysics, biotechnology and pharmacology that need a solid grasp of biosensor system technologies and applications, as well as students in related medical technological fields.
    Type of Medium: Online Resource
    Pages: XVIII, 328 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030764692
    Series Statement: Learning Materials in Biosciences,
    DDC: 610.72
    Language: English
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  • 74
    Keywords: Immunology. ; Neurosciences. ; Virology. ; Immunology. ; Neuroscience. ; Virology.
    Description / Table of Contents: I. Neuropathogenesis and Biomarkers -- New Potential Axes of HIV Neuropathogenesis with Relevance to Biomarkers and Treatment -- Neurocognitive Impairment and Associated Genetic Aspects in HIV Infection -- Inflammatory Mechanisms and Cascades Contributing to Neurocognitive Impairment in HIV/AIDS -- Neuroimaging Advances in Diagnosis and Differentiation of HIV, Comorbidities, and Aging in the cART Era -- II. Neurocognitive Impairments in Low-, Middle- and High-Income Countries – Incidence / Prevalence and Contexts -- Neurocognitive Complications of Pediatric HIV Infections -- Neurocognitive Complications of HIV Infection in Women: Insights from the WIHS Cohort -- Cultural Neuropsychology Considerations in the Diagnosis of HIV- Associated Neurocognitive Disorders -- Neurocognitive Complications of HIV Infection in Low-Income Countries -- Deep Phenotyping of HIV Neurocognitive Complications Among Individuals Residing in High-Income Countries -- Reliably Measuring Cognitive Change in the Era of Chronic HIV Infection and Chronic HIV-Associated Neurocognitive Disorders -- III. Comorbidities and Complications -- Geriatric Syndromes in People Living with HIV Associated with Ageing and Increasing Comorbidities: Implications for Neurocognitive Complications of HIV Infection -- Conceptualizing and Assessing Everyday Functioning in the Context of HIV-Associated Neurocognitive Disorders -- Neuropsychiatric Disorders, Emotional Disturbances, and Their Associations with HIV-Associated Neurocognitive Disorder -- Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders -- HIV-Associated Neurocognitive Disorder (HAND): Relative Risk Factors -- IV. Screening, Interventions and Clinical Management -- Screening for HIV-Associated Neurocognitive Disorders: Sensitivity and Specificity -- Behavioral and Physical Activity Interventions for HAND -- Targeting HIV-Related Neurocognitive Impairments with Cognitive Training Strategies: Insights from the Cognitive Aging Literature -- Clinical Treatment Options and Randomized Clinical Trials for Neurocognitive Complications of HIV Infection: Combination Antiretroviral Therapy, Central Nervous System Penetration Effectiveness, and Adjuvants.
    Abstract: This volume aims at presenting the latest international research and discoveries in the neurocognitive aspects and complications in HIV/AIDS, and how this understanding can shape and inform how we think about clinical practice and patient care in HIV/AIDS as well as lead to a better understanding of the underlying neuropathogenesis. The chapter, "Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders", of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: XVII, 545 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030807597
    Series Statement: Current Topics in Behavioral Neurosciences, 50
    DDC: 571.96
    Language: English
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  • 75
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy.
    Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
    Abstract: This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 38 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030795115
    Series Statement: Progress in Drug Research, 75
    DDC: 615
    Language: English
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  • 76
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Physiology. ; Oncology. ; Neurosciences. ; Developmental biology. ; Pharmacology. ; Physiology. ; Oncology. ; Neuroscience. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Pharmacological thinking in WNT signaling -- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically -- WNTs on exosomes -- Strategies to target LRPs in WNT signaling -- Targeting the receptor tyrosine kinase ROR1 by small molecules -- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors -- Disheveled proteins as crucial mediators of WNT signaling -- Destruction complex and regulation of CTNNB1 -- Strategies to therapeutically target WNT/PCP like signaling in disease -- Mining natural compounds to target WNT signaling - from mushrooms to corals -- FZD7 as a therapeutic target in intestinal cancer -- Targeting oncogenic WNT signaling with WNT derived peptides -- Targeting WNT signaling in lung pathology -- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting -- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy? -- Targeting WNT signaling as a risk.
    Abstract: This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made the recent years. Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. This book summarizes the current understanding of the basic and applied pharmacology in the WNT signaling system and bridges disciplines such as pharmacology, physiology, neurosciences, oncology and drug development.
    Type of Medium: Online Resource
    Pages: VIII, 422 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030854997
    Series Statement: Handbook of Experimental Pharmacology, 269
    DDC: 615
    Language: English
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  • 77
    Keywords: Plant physiology. ; Soil science. ; Physical geography. ; Plant biotechnology. ; Biotechnology. ; Plant Physiology. ; Soil Science. ; Earth System Sciences. ; Plant Biotechnology. ; Biotechnology.
    Description / Table of Contents: 1. Recent advances in plant adaptation to climate change – An introduction to compatible solutes -- 2. Osmosensing and signaling in plants - Potential role in crop improvement under climate change -- 3. Amino acids other than proline and their participation in abiotic stress tolerance -- 4. Engineering glycine betaine biosynthesis in alleviating abiotic stress effects in plants -- 5. Improvement of abiotic stress tolerance by modulating polyamine pathway in crop plants -- 6. Engineering fructan biosynthesis against abiotic stress -- 7. The γ-Aminobutyric Acid (GABA) towards abiotic stress tolerance -- 8. Sugar alcohols and osmotic stress adaptation in plants -- 9. Crosstalk of compatible solutes with other signalling pathways in plants -- 10. Effect and importance of compatible solutes in plant growth promotion under different stress conditions -- 11. Compatible solute engineering: An approach for plant growth under climate change.
    Abstract: Plants, being sessile and autotrophic in nature, must cope with challenging environmental aberrations and therefore have evolved various responsive or defensive mechanisms including stress sensing mechanisms, antioxidant system, signaling pathways, secondary metabolites biosynthesis, and other defensive pathways among which accumulation of osmolytes or osmo-protectants is an important phenomenon. Osmolytes with organic chemical nature termed as compatible solutes are highly soluble compounds with no net charge at physiological pH and nontoxic at higher concentrations to plant cells. Compatible solutes in plants involve compounds like proline, glycine betaine, polyamines, trehalose, raffinose family oligosaccharides, fructans, gamma aminobutyric acid (GABA), and sugar alcohols playing structural, physiological, biochemical, and signaling roles during normal plant growth and development. The current and sustaining problems of climate change and increasing world population has challenged global food security. To feed more than 9 billion, the estimated population by 2050, the yield of major crops needs to be increased 1.1–1.3% per year, which is mainly restricted by the yield ceiling. A major factor limiting the crop yield is the changing global environmental conditions which includes drought, salinity and extreme temperatures and are responsible for a reduction of crop yield in almost all the crop plants. This condition may worsen with a decrease in agricultural land or the loss of potential crop yields by 70%. Therefore, it is a challenging task for agricultural scientists to develop tolerant/resistant varieties against abiotic stresses. The development of stress tolerant plant varieties through conventional breeding is very slow due to complex multigene traits. Engineering compatible solutes biosynthesis by deciphering the mechanism behind the abiotic tolerance or accumulation in plants cell is a potential emerging strategy to mitigate adverse effects of abiotic stresses and increase global crop production. However, detailed information on compatible solutes, including their sensing/signaling, biosynthesis, regulatory components, underlying biochemical mechanisms, crosstalk with other signaling pathways, and transgenic development have not been compiled into a single resource. Our book intends to fill this unmet need, with insight from recent advances in compatible solutes research on agriculturally important crop plants.
    Type of Medium: Online Resource
    Pages: XII, 266 p. 28 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030806743
    DDC: 571.2
    Language: English
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  • 78
    Keywords: Life sciences. ; Education. ; Engineering. ; Social sciences. ; Humanities. ; Science. ; Mathematics. ; Life Sciences. ; Education. ; Technology and Engineering. ; Humanities and Social Sciences. ; Physical Sciences. ; Mathematics and Computing.
    Description / Table of Contents: Foreword (Hubert Hasenauer) -- Preface -- Chapter 1. Empowering researchers: Academic mentoring -- Chapter 2. The shape of science -- Chapter 3. Doctoral studies and all that -- Chapter 4. Early career years -- Chapter 5. Scientific storytelling -- Chapter 6. Scientific presentations -- Chapter 7. Research-driven teaching -- Chapter 8. Research cooperation and job applications -- Chapter 9. Behaviour and disappointments -- Chapter 10. Sustainable data management.
    Abstract: The pace of change in academia is ever increasing, which makes it difficult for anyone to stay up to date with what may be the right long-term strategy, or even the next step in mastering a PhD or to secure a fruitful academic career. Academic mentoring has proved to be helpful to many young researchers in difficult situations and mentoring programmes have been launched at many universities. In its most basic meaning, mentoring is a goal-oriented off-line conversation between a more experienced (mentor) and a less experienced (mentee) person with the objective to empower the mentee to make important work-related decisions. The first chapter of the book offers an introduction to academic mentoring and provides an overview of what academic mentoring entails. In the following chapters, important topics are discussed that may come up in mentoring conversations. These include scientific thinking, doctoral studies, behaviour and disappointments, scientific storytelling, teaching, scientific presentations, early career years, research cooperation, job applications and basic data management. The discussions in each of these chapters were designed with a view to provide food for thought and to invite self-reflection as well as continued discussions with peers and mentors. The book is written in a highly accessible style whilst restricting each chapter to the most essential information so that reading them can be accommodated in any busy schedule. It is not limited to any particular university or geographic region, since the author has worked in a number of different countries and encountered many different academic cultures. The text is also a useful handbook and reference to go with mentoring programmes.
    Type of Medium: Online Resource
    Pages: XIV, 145 p. 6 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030654672
    DDC: 570
    Language: English
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  • 79
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Forestry. ; Agricultural ecology. ; Conservation biology. ; Ecology . ; Soil science. ; Forestry. ; Agroecology. ; Conservation Biology. ; Soil Science.
    Description / Table of Contents: Preface -- Agroforestry for Ecosystem Services -- Agroforestry Practices for Soil Conservation and Resilient Agriculture -- Soil Health Ecosystem Services of Agroforestry -- Below-Ground Services in Vineyard Agroforestry Systems -- Selected Soil Properties Among Agroforestry, Natural Forest, Traditional Agriculture, and Palm Oil Land Uses in Central Kalimantan, Indonesia -- Water Quality and Quantity Benefits of Agroforestry and Processes: Long-Term Case Studies from Missouri, USA -- Enhanced Ecosystem Services Provided by Silvopastures -- Silvopasture for Food Security in a Changing Climate -- Potential Indicators to Assess the Sustainability of South American Forests Under Silvopastoral Management -- The Role of Temperate Agroforestry Practices in Supporting Pollinators -- Agroforestry for Biodiversity Conservation -- Cultural Ecosystem Services in Agroforests -- Carbon Sequestration Potential of Agroforestry in India -- Ecosystem Services of Agroforestry -- Agroforestry Integration and Multifunctional Landscape Planning for Enhanced Ecosystem Services from Treed Habitats -- Economic Valuation of Agroforestry Ecosystem Services -- Bibliography -- Index.
    Abstract: This book is a state-of-the-art compilation of the latest information on ecosystem services of agroforestry. The last two decades have seen a surge in literature on the ecosystem services of sustainable agriculture practices, including that of agroforestry; however, compilation and synthesis of such information from agroforestry have been limited. This book fills that void by bringing in a number of experts from around the world. In addition to presenting the multiple dimensions of ecosystem services provided by major agroforestry practices, the book also offers case studies from both tropical and temperate regions of the world. Information from this book can be used to design land management practices for climate change mitigation, ecosystem benefits, agricultural productivity and sustainability, and for survival and profitability of family farms and to conserve biodiversity. While synthesizing information of the biophysical aspects of ecosystem services, the book also outlines the socioeconomic and policy dimensions, including appropriate incentive models to enhance adoption of agroforestry so that society at large can enjoy these important benefits.
    Type of Medium: Online Resource
    Pages: XI, 510 p. 109 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030800604
    DDC: 634.9
    Language: English
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  • 80
    Keywords: Biotechnology. ; Religion and sociology. ; Biotechnology. ; Sociology of Religion. ; Biotechnology.
    Description / Table of Contents: Introduction -- Chapter 1. Religion outside one’s homeland -- Chapter 2. Asylum seekers, immigrants, new Europeans: setting the scene -- Chapter 3. Young foreign Christian Catholics: a portrait -- Chapter 4. Being Muslim in Hard Times in Europe: New Opportunities and Old Challenges -- Chapter 5. God will save us! Faith, identity and practices in refugee welcoming centers -- Chapter 6. Similarities and differences: the Me3 generation at the mirror -- Chapter 7. Does religious capital still matter? Local secularized societies face with a renewal of religious pluralism -- Concluding remarks.
    Abstract: This monograph considers the Catholic/Christian religious identity of young immigrants within the migratory diasporas in Southern Europe. It details important ethnographical work on various groups, such as the family, ethnic communities, and peers. The author also considers the role of institutional figures in mainstream society. These include teachers, administrators, and social workers. This valuable research material helps readers to better understand the viewpoint of young people (especially the children of immigration) in relation to various environments which are important in their lives. The investigation examines theoretical and practical questions regarding the study of relations between religion and migrations. It pays particular attention to both the youth perspective and the effects of the current refugee crisis on the perception of religious diversity and identity. Coverage also looks at similarities and differences between young migrant and their native peers. In addition, three case studies further help illustrate the main points of the author's argument. The book uses preliminary research carried out in Italy. It also features interviews collected in Portugal and Spain. Those interviewed include people with migratory background who are permanent residents, belong to the second generations, or are recently-arrived asylum seekers. Overall, the author provides readers with an interesting and innovative portrait of children of immigrants and their relations with faith in the post-secularized Europe: indeed, by considering both academic debates and original empirical data, the book offers the possibility of reframing the link between migrations and religious identities. .
    Type of Medium: Online Resource
    Pages: XXVII, 130 p. 5 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030840563
    DDC: 660.6
    Language: English
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  • 81
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Immunology. ; Pharmacology. ; Biochemical markers. ; Analytical chemistry. ; Biotechnology. ; Immunology. ; Pharmacology. ; Biomarkers. ; Bioanalytical Chemistry. ; Biotechnology.
    Description / Table of Contents: Microheterogeneity of antibody molecules -- Part I: Analytical Methods -- Lectin and LC based methods for immunoglobulin (G) glycosylation analysis -- Mass spectrometry-based methods for immunoglobulin G N-glycosylation analysis -- CE based methods for Ig(G) glycosylation analysis -- Automation of Ig glycosylation analysis -- Bioinformatics in immunoglobulin glycosylation analysis -- Part II: Biosynthesis & Regulation -- N-glycan biosynthesis: Basic principles and factors affecting its outcome -- Genetic regulation of immunoglobulin G glycosylation -- Epigenetics of immunoglobulin G glycosylation -- IgG changes in aging and other inflammatory conditions -- Estrogen-driven changes in immunoglobulin G Fc glycosylation -- Part III: Effector Functions & Diseases -- Sweet rules – linking glycosylation to antibody function -- Immunoglobulin G glycosylation in diseases -- Immunoglobulin A glycosylation and its role in diseases -- Part IV: Applications -- Importance and monitoring of therapeutic immunoglobulin G glycosylation -- Glycosylation of plant-produced immunoglobulins -- The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine -- Glycosylation of antigen-specific antibodies - Perspectives on immunoglobulin G glycosylation in vaccination and immunotherapy.
    Abstract: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 591 p. 66 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030769123
    Series Statement: Experientia Supplementum, 112
    DDC: 571.96
    Language: English
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  • 82
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Chemistry, Organic. ; Food science. ; Biotechnology. ; Pharmacology. ; Organic Chemistry. ; Food Science. ; Biotechnology.
    Description / Table of Contents: Chapter 1 The World of Carbohydrates -- Chapter 2 Basic Knowledge of Glycobiology -- Chapter 3 Carbohydrates involved in Diseases -- Chapter 4 Detection of Carbohydrate by Colorimetric Methods -- Chapter 5. Analytical Techniques to Study Carbohydrates -- Chapter 6 Monosaccharide Composition Analysis -- Chapter 7 Carbohydrate Analysis of Glycoconjugates -- Chapter 8 Structural Characterization of Released Glycans -- Chapter 9 Analysis of Sialic Acids -- Chapter 10 Carbohydrate Microarray Technology -- Chapter 11 Analysis of Carbohydrates by Mass Spectrometry -- Chapter 12 Analysis of Carbohydrates by Nuclear Magnetic -- Chapter 13 Glycobioinformatics -- Chapter 14 Concluding Remarks. .
    Abstract: The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.
    Type of Medium: Online Resource
    Pages: XXV, 350 p. 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030777913
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 615
    Language: English
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  • 83
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Chapter 1. Economic and Academic Importance of Rye -- Chapter 2. Hybrid Rye Breeding -- Chapter 3. Rye Cytogenetics and Chromosome Genomics -- Chapter 4. The B Chromosome of Rye -- Chapter 5. Dissection of the Rye Genome by the Gametocidal System -- Chapter 6. Evolution and Domestication of Rye -- Chapter 7. Assembling the Rye Genome -- Chapter 8. The Gene and Repetitive Element Landscape of the Rye Genome -- Chapter 9. Bridging the Genotype-Phenotype Gap for Precision Breeding in Rye -- Chapter 10. Genomics of Self-Incompatibility and Male-Fertility Restoration in Rye -- Chapter 11. Genetics and Genomics of Stress Tolerance.
    Abstract: This book celebrates the dawn of the rye genomics era with concise, comprehensive, and accessible reviews on the current state of rye genomic research, written by experts in the field for students, researchers and growers. To most, rye is the key ingredient in a flavoursome bread or their favourite American whisky. To a farmer, rye is the remarkable grain that tolerates the harshest winters and the most unforgiving soils, befitting its legacy as the life-giving seed that fed the ancient civilisations of northern Eurasia. Since the mid-1900s, scientists have employed genetic approaches to better understand and utilize rye, but only since the technological advances of the mid-2010s has the possibility of addressing questions using rye genome assemblies become a reality. Alongside the secret of its unique survival abilities, rye genomics has accelerated research on a host of intriguing topics such as the complex history of rye’s domestication by humans, the nature of genes that switch fertility on and off, the function and origin of accessory chromosomes, and the evolution of selfish DNA.
    Type of Medium: Online Resource
    Pages: XIX, 236 p. 73 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030833831
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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  • 84
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agricultural biotechnology. ; Biotechnology. ; Soil science. ; Botany. ; Environment. ; Agricultural Biotechnology. ; Biotechnology. ; Soil Science. ; Plant Science. ; Environmental Sciences.
    Description / Table of Contents: 1. Introduction -- 2. Biotechnology of 21st Century -- 3. Considerations on the Scaling of biological and chemical reactors -- 4. Design of a cultivation media for the production of metabolites with practical application in the biodegradation of industrial dyes -- 5. Obtaining and characterizing new biomaterials based on starch, for use in the food and health industry -- 6. Influence of immersion time in pitahaya (Hylocereus undatus) proteolytic enzyme solutions on the texture of bovine meat -- 7. Determination of free amino acids in fermented and toasted cocoa (Theobroma cacao) samples, using high performance liquid chromatography with UV detection by diode arrangement -- 8. Characterization of cassava and bee wax residues for their use in the obtaining of bioplastic -- 9. Development of a thermoplastic material from the residues of the banana (Musa paradisiaca) -- 10. Chemical ecology and its role in the conservation of threatened species: a case study in the Galapagos islands -- 11. Energy evaluation of solid biofuels made from mixtures of lignocellulosic biomass -- 12. Reforestation and conservation of vegetable germ plasm: challenges and expectations -- 13. Characterization of Moniliophthora roreri evans and evaluation of biological control alternatives in cacao (Theobroma cacao), for the Ecuadorian amazon -- 14. Application of biotechnology to the search and selection of PGPR in the control of phytosanitary problems in cocoa (Theobroma cacao) and banana (Musa acuminata) -- 15. Sustainability of organic quinoa cultivation (Chenopodium quinoa) in communities of colta Ecuador -- 16. Effects of artificial light intensity and temperature on the growth of lettuce (Lactuca sativa l.) in a vertical urban farm in low cost indoor -- 17. Efficiency of led lights in the propagation and field of summer flowers in Ecuador -- 18. Evaluation of extraction methods to obtain a natural flocculant from the tamarind seed (Tamarindus indica) -- 19. Bicomponent adsorption of Brilliant blue FCF and tartrazine under dynamic conditions using rice husk -- 20. Kinetic approach to the biocoagulation process of mixtures of Moringa oleífera and Caesalpinia spinosa in synthetic turby water -- 21. Sustainable alternatives in the treatment of liquid industrial waste -- 22. Biodegradation of industrial dyes with enzymatic extracts obtained in FES and FEL systems with Pleurotus djamor -- 23. Removal of petroleum hydrocarbons from medium and soil (lab & field conditions) by microorganisms isolated from the Ecuadorian amazon rainforest -- 24. Chemistry of natural products -- 25. Evaluation of the antimicrobial activity of natural extracts of altamisa (Ambrosia artemisiifolia) and melissa (Melissa officinallis) for the control of pathogenic agents -- 26. Phenolic compounds of cocoa (Theobroma cacao) shell extraction and antimicrobial activity -- 27. Susceptibility to antimicrobials in strains of environmental origin, a public health problem -- 28. Inhibition effect of oregano (Origanum vulgare) essential oil on an active biodegradable film -- 29. Current Challenges and Future Prospective of Biotechnology.
    Abstract: This contributed volume compiles the latest improvements in the field of biotechnology. It focuses on topics that comprises industrial, environment, agricultural and medical related issues to technology and biological studies and exhibits the correlation between the biological world and the dependence of humans on it. The book is organized into five parts covering the role of biotechnology in industrial products, environmental remediation, agriculture and pharmacological agents. Ranging from micro-scale studies to macro, it covers a huge domain of agricultural biotechnology and focuses on important commercial crops (e.g. cacao and coffee), arbuscular mycorrhizal fungi, flow and distribution of phosphorus in agricultural soils in the Latin American region. Overall, the book portrays the importance of modern biotechnology and its role in solving the problems in modern day life. The book is a ready reference for practicing students, researchers of environmental engineering, chemical engineering, agricultural engineering, and other allied fields likewise.
    Type of Medium: Online Resource
    Pages: XXII, 448 p. 67 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030801083
    DDC: 630
    Language: English
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  • 85
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Physiology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Physiology. ; Internal Medicine.
    Description / Table of Contents: Basic structure, physiology and biochemistry of connective tissues and extracellular matrix collagens -- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life -- Basic Components of Connective Tissues and Extracellular Matrix: Fibronectin, Fibrinogen, Laminin, Elastin, Fibrillins, Fibulins, Matrilins, Tenascins and Thrombospondins -- Proteoglycans and Diseases of Soft Tissues -- Growth Factor Roles in Soft Tissue Physiology and Pathophysiology -- Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-β Signaling -- The Pathophysiology and Pathogenesis of Marfan Syndrome -- Ehlers-Danlos syndromes, joint hypermobility and hypermobility spectrum disorders -- Ehlers–Danlos Syndrome Associated with Glycosaminoglycan Abnormalities -- Loeys-Dietz Syndrome -- Meester-Loeys syndrome -- Clinical and Molecular Delineation of Cutis Laxa Syndromes: Paradigms for Elastic Fiber Homeostasis -- Collagen VI Muscle Disorders: Mutation Types, Pathogenic Mechanisms and Approaches to Therapy -- Connective Tissue Disorders in Domestic Animals.
    Abstract: This volume represents a substantially revised and updated 2nd edition of a reference handbook on major structural components of soft connective tissues and a whole slew of heritable diseases of soft connective tissues. The number of clearly identifiable and distinct disorders has grown somewhat since the 1st edition in 2014, e.g., Ehlers-Danlos syndrome has now 13 entities. A brand new syndrome, Meester Loeys syndrome carrying the name of Bart Loeys was added as a companion to Loeys-Dietz syndrome. Numerous variations of cutis laxa and joint mobility disorders have been discovered taking advantage of recent advancements in genetic analysis. We have acquired better understanding of pathogenesis and biochemical changes in some other, more established entities, such as Marfan and collagen VI myopathies where better management and possible treatment are on the horizon. Even in the case of connective tissue diseases in domestic animals some progress has been made. All these updates were contributed by a group of distinguished and preeminent physicians and scientists, all of them not just working in the field but making new discoveries described by them. Readers will notice that seemingly there is an overlap among many of these disorders. And indeed, many of them, if not most are interconnected because of the prominent roles of TGFβ, of fibrillin microfibrils and collagen fibril assembly (and other molecules) playing in connective tissues physiology, and by extension in pathogenesis of many disorders described in the book. What I found particularly helpful that author(s) of each chapter bring their own perspective even when described closely related mechanism of the disease. These observations should help with diagnosis and management of such cases. The first chapters are more general, concentrating more on the physiology, structure and biochemistry of normal soft tissues. That should help in better understanding of the pathophysiology. Last but not least, the chapters are very readable, more like detective stories than dry description of genetic/biochemical defects. I do hope that basic scientists and clinicians with similar and diverse interests alike will appreciate this volume and will be inspired by it to develop their research in the field.
    Type of Medium: Online Resource
    Pages: IX, 343 p. 1 illus. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030806149
    Series Statement: Advances in Experimental Medicine and Biology, 1348
    DDC: 610.72
    Language: English
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  • 86
    Keywords: Neurosciences. ; Nervous system Diseases. ; Neurology . ; Neurophysiology. ; Neuropsychology. ; Neurons. ; Neuroscience. ; Neurological Disorders. ; Neurology. ; Neurophysiology. ; Neuropsychology. ; Cellular Neuroscience.
    Description / Table of Contents: Introduction: Neuroglia in psychiatric disorders -- Chapter 1. Astrocytes: The housekeepers and guardians of the CNS -- Chapter 2. Principles of astrogliopathology -- Chapter 3. Morphological appearance of astroglia in neuropsychiatric disorders -- Chapter 4. Astrocytes and neurotransmission: Glutamate and GABA in cognitive and mood disorders -- Chapter 5. Astroglia in bipolar disorder -- Chapter 6. Astroglia abnormalities in mood disorders -- Chapter 7. Astroglia in major depression and suicide -- Chapter 8. Neuroglia in Schizophrenia -- Chapter 9. Glutamate turnover in Schizophrenia -- Chapter 10. Astroglia and dopanime transmission in Schizophrenia -- Chapter 11. Kynurenic acid in Schyzophrenia -- Chapter 12. Astrocytes in addictive disorders -- Chapter 13. Astroglia in the vulnerability and maintenance of alcohol dependence -- Chapter 14. Astroglia in response to stress -- Chapter 15. Astroglia and Obsessive compulsive disorder -- Chapter 16. Astrocytes in regulation of food intake -- Chapter 17. Astrocytes in anorexia nervosa -- Chapter 18. Astroglial serotonin receptors as the central target of classic antidepressants -- Chapter 19. Lithium targets astrocytes -- Epilogue.
    Abstract: This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.
    Type of Medium: Online Resource
    Pages: VI, 377 p. 36 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030773755
    Series Statement: Advances in Neurobiology, 26
    DDC: 612.8
    Language: English
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  • 87
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Genetics. ; Biotechnology. ; Agriculture. ; Plant Science. ; Genetics and Genomics. ; Biotechnology. ; Agriculture.
    Description / Table of Contents: Chapter 1. Economic Value and Research Significance of Moso Bamboo -- Chapter 2. Moso Bamboo Germplasm Resources in China/World -- Chapter 3. Biological Traits of Moso Bamboo -- Chapter 4. Moso Bamboo Genome -- Chapter 5. Moso Bamboo Transposon -- Chapter 6. Transcriptome of Moso Bamboo -- Chapter 7. Moso Bamboo Alternative Splicing (AS ) and Polyadenylation -- Chapter 8. Characterizations and Function of Transcript Factor Gene families -- Chapter 9. MicroRNAs of Moso Bamboo -- Chapter 10. Mitochondrial Genome of Endophytic Fungi from the Seed of Moso Bamboo -- Chapter 11. Breeding Strategies of Moso Bamboo.
    Abstract: This book is the first comprehensive compilation describing the botanical traits, genetic resources, whole genome sequencing, Mitochondrial genome, transcriptomes of different organs with developmental stages, transcription factors, delineating gene evolution of gene family in Bambusoideae, alternative splicing (AS) and polyadenylation, case studies for economically important traits such as internode length, shoot fast growing, flowering, ageing and stress-resistant genes and small RNAs-mediated gene regulation of moso bamboo flowering and other developmental stages. Applications of transcriptome and genome approaches in moso bamboo in general and the prospects of transgenic breeding and genome editing technologies in bamboo are also discussed. Altogether, the book comprises eleven chapters covered over 200 pages authored by the researchers involved in genomic science, molecular biology, and breeding. This book appeals to graduate students, post-graduate students, research scholars, researchers, and industry players in the field of plantation bamboo in general, bamboo processing and bamboo garden owner and fans of bamboo culture in particular.
    Type of Medium: Online Resource
    Pages: XXII, 208 p. 124 illus., 110 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030808365
    Series Statement: Compendium of Plant Genomes,
    DDC: 580
    Language: English
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  • 88
    Keywords: Human physiology. ; Human Physiology.
    Description / Table of Contents: Cellular and biochemical mechanisms of obesity -- The role of inflammation in obesity -- Hypothalamic inflammation and malfunctioning glia in the pathophysiology of obesity -- The role of the inflammasome in obesity -- Adipose tissue macrophages and their polarization in health and obesity -- Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation -- The interplay between adipocytes and immune system cells in the pathophysiology of obesity -- Neuropeptides in Obesity and Metabolic Disease -- Adiposity and the Role of Neuroendocrine Hormones in Energy Balance -- Obesity in menopause -- Ovarian hormones and obesity -- The role of tissue-specific glucocorticoids in central obesity -- Thyroid function in obesity -- Glucocorticoid hormones: cause or cure for obesity -- Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota -- Recent advances in leptin and obesity -- Pathophysiology of obesity due to neurohormonal dysregulation and autophagy -- The Role of the Autonomic Nervous System in the Pathophysiology of Obesity -- Disturbance of neuronal signals in the pathophysiology of obesity -- The sympathetic neuro-adipose connection and the control of body weight -- Sympathetic activation in obesity -- Obesity-associated sympathetic overactivity in children and adolescents: the role of catecholamine resistance in lipid metabolism -- Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome -- Should the sympathetic nervous system be a target to improve obesity? -- Metabolic Syndrome and Oxidative Stress: A Complex Relationship -- The role of oxidative stress in the pathogenesis of obesity -- How effective are antioxidant supplements in obesity -- Oxidative stress in obesity: a critical component in human diseases -- Cellular mechanisms involved in the pathophysiology of obesity during oxidative stress -- Oxidative stress and metabolic pathologies: from an adipocentric point of view -- Oxidative stress contributes to the pathogenesis of obesity -- The genetics of oxidative stress in obesity -- Increased oxidative stress is associated with adipocyte fat accumulation -- The vicious cycle of oxidative stress and obesity -- GPCR-Mediated Signaling of Metabolites in the pathophysiology of obesity -- Ceramide signaling in obesity -- The role of the triggering receptor in the pathophysiology of obesity -- The AMPK pathway in the development of obesity -- Interleukin-1 superfamily: Divergent roles in obesity -- Ghrelin Receptor Mutations and Human Obesity -- Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism -- JAK/STAT signaling pathway in the development of obesity -- SIRT1 and SIRT3 as mediators for the development of obesity -- Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity -- Interplay between Obesity and cGMP Signaling in adipose tissue.
    Abstract: Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood. Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters). This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease. .
    Type of Medium: Online Resource
    Pages: XVIII, 414 p. 72 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030847630
    Series Statement: Advances in Biochemistry in Health and Disease, 23
    DDC: 612
    Language: English
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  • 89
    Keywords: Toxicology. ; Pharmacology. ; Environment. ; Toxicology. ; Pharmacology. ; Environmental Sciences.
    Description / Table of Contents: Overview of Nanotoxicology in Humans and the Environment: Developments.-The potential adverse effects of engineered nanomaterial exposure to human health following pulmonary, oral and dermal exposure @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:3 0 0 0 1 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US; mso-fareast-language:ZH-CN;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:11.0pt; mso-ansi-font-size:11.0pt; mso-bidi-font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; 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    Abstract: The book covers the area of ‘Nanotoxicology’ but primarily from the point of view of nanotoxicology at the interface with other disciplines including human toxicology; environmental toxicology; characterization, dose and transformations; regulation; public and elite group perceptions; and interactions with innovation.Nanotoxicology in Humans and the Environment is written for researchers in nanotoxicology in academia, industry, government, and research students. Given the rapid development, the maturing of the discipline and its importance in current regulation and industry development (eg REACH, TSCA), the book is very timely.
    Type of Medium: Online Resource
    Pages: V, 259 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030798086
    Series Statement: Molecular and Integrative Toxicology,
    DDC: 615.90072
    Language: English
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  • 90
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical genetics. ; Neurosciences. ; Bioinformatics. ; Medical Genetics. ; Neuroscience. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Stratification of patients with Chronic Obstructive Pulmonary Disease using Volatile Organic Compounds -- 2-Evidence-based Leadership: A Study of its Application to General Hospital of the Public Health System through the Implementation Leadership Scale -- 3-Greek nurses’ perception of hospital ethical climate. A cross-sectional study -- 4-Investigating the main causes of conflicts and the managements strategies are used by healthcare professionals. The case of general hospital of Arta -- 5-Incidence of deep vein thrombosis and its effect on health related quality of life among nurses of Greek public hospital. A multicenter study -- 6-Factors affecting anxiety and depression in caregivers of hemodialysis patients -- 7-Hand grip strength in patients on hemodialysis: An observational study -- 8-The effect of spirituality on illness perceptions in patients undergoing hemodialysis -- 9-Validation of the STOP-Bang Questionnaire in Greek patients suffering from obstructive sleep apnea -- 10-The role of Pythagorean Self-Awareness Intervention in obstructive sleep apnea. A randomized controlled trial -- 11-Tissue characterization in Cardiology. Moving beyond function -- 12-Psychiatric care in acute care units with locked doors: Nursing care providers’ perceptions and experiences -- 13-Researching nursing students’ attitudes towards mental health practice: cultural adaptation and validation of the Greek version of the Acceptability of Locking the Door Questionnaire in acute psychiatric care -- 14-Compliance of bronchial asthma patients' with the Mediterranean diet -- 15-Nurses’ experiences of psychiatric care in acute care units with an open door policy -- 16-Validation of the Greek Version of Hedonic, Eudaimonic and Extrinsic Motives for Activities (HEEMA) Instrument -- 17-Event-Related Rumination Inventory: A Validation Process in the Greek Language -- 18-The job rotation of nursing staff and its effects on nurse`s satisfaction and occupational engagement -- 19-The burden on carers with multiple sclerosis -- 20-Attitudes of the general population regarding patient information for a chronic and life-threatening disease. A cross-sectional study -- 21-Assessment of healthcare professionals’ knowledge and awareness on aspects related to ionizing radiation examinations in Athens, Greece -- 22-Medication errors and their correlation with nurse's satisfaction. The case of the hospitals of Lasithi, Crete -- 23-Health-Related Quality of Life and Living Costs of HIV-Infected Patients -- 24-Evaluation of anxiety and depression in women undergoing mastectomy in Greece -- 25-The effect of emotional intelligence on caring behaviors among psychiatric nurses in Greece -- 26-Investigating nursing leadership in intensive care units of hospitals of Northern Greece and its relationship to the working environment -- 27-Health-Related Quality of Life and Rehabilitation Costs of Patients with Amputated Limb -- 28-Anxiety and depression in hemodialysis: Sex differences -- 29-Patient knowledge, adherence to the therapeutic regimen, and quality of life in hemodialysis -- 30-The burden of caregivers of patients after hip replacement and its impact on the cost of living of the family -- 31-The effects of exercise in patients with Sarcopenia -- 32-Fluid dynamics derived parameters in coronary vessels -- 33-Level of knowledge about COPD among patients and caregivers -- 34-Increased body mass index (BMI) and sunscreen use are associated with inadequate vitamin D status in Greek adults in winter -- 35-The effect of whole-body cryostimulation in healthy adults -- 36-Exhaled Nitric Oxide (FeNO) in patients hospitalized for an exacerbation of bronchiectasis and/or COPD -- 37-Formulation and Evaluation of Dermatological product containing Niacinamide -- 38-Exhaled breath condensate and dyspnea in COPD -- 39-The Effects of Pythagorean Self-Awareness Intervention on Irritable Bowel Syndrome Patients: A Non-Randomized Controlled Trial -- 40-Adults’ stress response to unexpected oral and arithmetic tasks in supine position -- 41-Triangles and family engagement in drug and alcohol addiction treatment -- 42-Use of fortified bread for addressing vitamin D deficiency. .
    Abstract: The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The increase in the average length of life leads to the development of various diseases in the elderly population. This volume focuses on the sessions from the conference on Geriatrics.
    Type of Medium: Online Resource
    Pages: XXVII, 389 p. 27 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030787714
    Series Statement: Advances in Experimental Medicine and Biology, 1337
    DDC: 616.042
    Language: English
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  • 91
    Keywords: Food Microbiology. ; Toxicology. ; Food Analysis. ; Chemistry. ; Food Safety measures. ; Nutrition   . ; Fungi. ; Mycology. ; Microbiology. ; Food Microbiology. ; Toxicology. ; Food Chemistry. ; Food Safety. ; Nutrition. ; Fungi.
    Description / Table of Contents: 1. Aflatoxins: An Introduction -- Prof. Dr. Carlos A. F. Oliveira -- Department of Food Engineering, School of Animal Sciences and Food Engineering, University of Sao Paulo, Brazil -- 2. Aflatoxins Biosynthesis -- Dr. Carlos Corassin -- Department of Food Engineering, School of Animal Sciences and Food Engineering, University of Sao Paulo, Brazil -- 3. Worldwide Prevalence of Aflatoxins in Food and Feed -- Prof. Dr. Yun Yun Gong -- School of Food Science and Nutrition, University of Leeds, Leeds, United Kingdom -- 4. Aflatoxins Health Impacts on Infants and Children -- Dr. Michael N Routledge -- School of Medicine, University of Leeds, Leeds, United Kingdom -- 5. Aflatoxins Health Impacts on Adults and Elderly -- Prof. Dr. Yun Yun Gong -- School of Food Science and Nutrition, University of Leeds, Leeds, United Kingdom -- 5. Aflatoxins Health Impacts on Adults and Elderly -- Prof. Dr. John Groopman -- Bloomberg School of Public Health, Johns Hopkins University, United States of America -- 6. Regulations for Aflatoxins in Developing and Industrialized Economies -- Dr. Khalid Rehman Hakeem -- Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia -- 7. Detection and Quantification of Aflatoxins -- Dr. Amir Ismail -- Institute of Food Science and Nutrition, Faculty of Agricultural Sciences, Bahauddin Zakariya University, Multan, Pakistan -- 8. Removal of Aflatoxins -- Dr. Muhammad Riaz -- Institute of Food Science and Nutrition, Faculty of Agricultural Sciences, Bahauddin Zakariya University, Multan, Pakistan -- 9. Physical Decontamination and Degradation of Aflatoxins -- Dr. Saeed Akhtar -- Institute of Food Science and Nutrition, Faculty of Agricultural Sciences, Bahauddin Zakariya University, Multan, Pakistan -- 10. Chemical Degradation of Aflatoxins -- Dr. Paula Alvito -- Food and Nutrition Department, National Institute of Health Doutor Ricardo Jorge, Lisboa, Portugal -- 11. Biological Decontamination and Degradation of Aflatoxins -- Isabelle P. Oswald -- Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, Toulouse, France -- 12. Impact of Climate Change on Aflatoxins Contamination in Food Commodities -- Dr. Shinawar Waseem -- Department of Food Science, Faculty of Agricultural Sciences, University of the Punjab, Lahore, Pakistan -- 13. Summary -- Dr. Amir Ismail -- Institute of Food Science and Nutrition, Faculty of Agricultural Sciences, Bahauddin Zakariya University, Multan, Pakistan.
    Abstract: Mycotoxins are the metabolites of fungus and are reported to contaminate nearly 25% of the food produced worldwide. The mycotoxins of most significance are the aflatoxins due to their severe health implications and their prevalence in food commodities on a larger scale. Aflatoxins are produced by certain species of fungi the most prominent among which are Aspergillus flavus, A. parasiticus and A. nominous. Food commodities of African and South Asian countries are especially reported to have aflatoxins well beyond the allowable limits but due to the global trade of food commodities developed countries are also prone towards the perils of aflatoxins. Moreover, climate changes may have a substantial impact on the distribution and global prevalence of aflatoxins in the near future. The International Agency for Research on Cancer (IARC) has classified the aflatoxins as group 1 category carcinogen. Aflatoxins are also reported as teratogenic, mutagenic, growth retardant, immunosuppressant and may also cause nervous system and reproductive system disorders. Preventive approaches involving good manufacturing from “farm to fork” are the major focus of the current food industry. The aim of our book is to provide readers with the most recent data and up-to-date studies from aflatoxins research, with specific focuses on (i) the impact of aflatoxins on human health, (ii) new approaches by the researchers from different parts of the world to degrade aflatoxins and (iii) potential preventive approaches that can significantly lessen the burden of aflatoxins in food products .
    Type of Medium: Online Resource
    Pages: XIX, 302 p. 43 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030857622
    DDC: 664.001579
    Language: English
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  • 92
    Keywords: Clinical medicine Research. ; Statistics . ; Data mining. ; Big data. ; Clinical Research. ; Applied Statistics. ; Data Mining and Knowledge Discovery. ; Big Data.
    Description / Table of Contents: Chapter 1. General Introduction -- Chapter 2. Mathematical Models for Separating Quantiles from One Another -- Part I: Simple Univariate Regressions versus Quantile -- Chapter 3. Traditional and Robust Regressions versus Quantile -- Chapter 4. Autoregressions versus quantile -- Chapter 5. Discrete Trend Analysis versus Quantile -- Chapter 6. Continuous Trend Analysis versus Quantile -- Binary Poisson / Negative Binomial Regression versus Quantile -- Chapter 8. Robust Standard Errors Regressions versus Quantile -- Chapter 9. Optimal Scaling versus Quantile Regression -- Chapter 10. Intercept only Poisson Regression versus Quantile -- Part II: Multiple Variables Regressions versus Quantile -- Chapter 11. Four Predictors Regressions versus Quantile -- Chapter 12. Gene Expressions Regressions, Traditional versus Quantile -- Chapter 13. Koenker's Multiple Variables Regression with Quantile -- Chapter 14. Interaction Adjusted Regression versus Quantile -- Chapter 15. Quantile Regression to Study Corona Deaths -- Chapter 16. Laboratory Values Predict Survival Sepsis, Traditional Regression versus Quantile -- Chapter 17. Multinomial Poisson Regression versus Quantile -- Chapter 18. Regressions with Inconstant Variability versus Quantile -- Chapter 19. Restructuring Categories into Multiple Dummy Variables versus Quantile -- Chapter 20. Poisson Events per Person per Period of Time versus Quantile -- Part III: Special Regressions versus Quantile -- Chapter 21. Two Stage Least Squares Regressions versus Quantile -- Chapter 22. Partial Correlations versus Quantile Regressions -- Chapter 23. Random Intercept Regression versus Quantile -- Chapter 24. Regression Trees versus Quantile -- Chapter 25. Kernel Regression versus Quantile -- Chapter 26. Quasi-likelihood Regression versus Quantile -- Chapter 27. Summaries.
    Abstract: Quantile regression is an approach to data at a loss of homogeneity, for example (1) data with outliers, (2) skewed data like corona - deaths data, (3) data with inconstant variability, (4) big data. In clinical research many examples can be given like circadian phenomena, and diseases where spreading may be dependent on subsets with frailty, low weight, low hygiene, and many forms of lack of healthiness. Stratified analyses is the laborious and rather explorative way of analysis, but quantile analysis is a more fruitful, faster and completer alternative for the purpose. Considering all of this, we are on the verge of a revolution in data analysis. The current edition is the first textbook and tutorial of quantile regressions for medical and healthcare students as well as recollection/update bench, and help desk for professionals. Each chapter can be studied as a standalone and covers one of the many fields in the fast growing world of quantile regressions. Step by step analyses of over 20 data files stored at extras.springer.com are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology(2000-2002). From their expertise they should be able to make adequate selections of modern quantile regression methods for the benefit of physicians, students, and investigators. .
    Type of Medium: Online Resource
    Pages: XII, 290 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030828400
    DDC: 615.50724
    Language: English
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  • 93
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Toxicology. ; Molecular biology. ; Cytology. ; Immunotoxicology. ; Environment. ; Toxicology. ; Molecular Biology. ; Cell Biology. ; Cell Biology. ; Immunotoxicity. ; Environmental Sciences.
    Description / Table of Contents: Male infertility: a complete guide to lifestyle and environmental factors -- Use of folic acid in the treatment of oxidative-stress associated male infertility: a myth or reality? -- Methylglyoxal induced mitochondrial perturbation and neuronal toxicity in Alzheimer disease -- Free radicals-mediated oxidative damage in memory loss: Are antioxidant therapies useful? -- ROS-induced neural toxicity in Parkinson's Disease -- Cyclin-dependent Kinase in oxidative stress and development of cancer -- Radiation induced free radical formation lead to head and neck cancer -- Pathophysiology of radiations: Radiofrequency electromagnetic radiation oxidative stress and carcinogenesis -- Heavy metal contamination induced oxidative tress lead to neurodegenerative diseases -- Networking of nanoparticles toxicity in environment and possible role of ROS in disease mechanism -- Free radicals and microbes in nature -- Relevance of ROS and NOS in Leishmaniasis: A recent update -- Alcohol-induced neuronal toxicity in Alzheimer disease.
    Abstract: The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of free radical research and environmental toxicity. This book presents various state-of-the-art chapters of recent progress in the field of cellular toxicology and clinical manifestations of various disorders. Topics include cell signaling, various risk factors, the pathophysiology of disease instigation and distribution, mechanistic insights into metal and nanoparticle toxicity, neural toxicity, nongenotoxic carcinogenicity, immune and idiosyncratic toxicity, prevention, biomarkers related to disease progression and therapeutic strategies. In particular, this book provides valuable insight for researchers, pathologists, and clinicians with an interest in toxicological research and cellular impairments with special emphasis on therapeutic advancement.
    Type of Medium: Online Resource
    Pages: XIV, 392 p. 71 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030834463
    Series Statement: Molecular and Integrative Toxicology,
    DDC: 615.90072
    Language: English
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  • 94
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food Microbiology. ; Food science. ; Food Microbiology. ; Food Science.
    Description / Table of Contents: 1-Introduction to membrane separation of bioactive compounds; challenges and opportunities -- 2-An overview of food bioactive compounds and their properties -- 3-Purification of phenolic-based molecules from agro-food by-products via pressure-driven membrane processes -- 4-Food bioactive ingredients processing using membrane distillation -- 5-Recovery of high-added value compounds from agro-food products using electrodialysis -- 6-Separation of bioactive peptides and proteins from by-products and co-products through membranes -- 7-Separation of polyphenols and carotenoids using nanofiltration -- 8-Recovery of volatile aroma molecules from agro-food systems by means of pervaporation -- 9-Separation of bioactive compounds from fermentation broths using membranes -- 10-Recovery of high added value compounds from microalgae cultivation using membrane Technology -- 11-Coupling of Membrane Technology with Emerging Technologies for the Recovery of Bioactives -- 12-Ionic-liquid membranes (microemulsions) for the separation of bioactive compounds -- 13-Modelling in membrane separation of bioactives.
    Abstract: This book covers current developments in membrane-based technologies for the successful recovery of food bioactive ingredients and molecules. Chapters explore emerging technologies, such as microfiltration, ultrafiltration, nanofiltration, and membrane distillation, for the selective concentration and food ingredients from food by-products, as well as techniques, such as pervaporation, for the selective separation and recovery of aroma compounds. The text provides one of the first examinations of other membrane-based technologies, such as liquid membranes (microemulsions), membrane distillation (MD) and pervaporation (PV), as thermal driven membrane processes. The separation of metabolites from microalgae and fermentation broths using membrane technologies is also covered. Researchers in food science, pharmaceutics and biotechnology looking to stay up-to-date on bioactive recovery, as well as membranologists exploring new applications for membrane-based technologies, will find this text a useful resource.
    Type of Medium: Online Resource
    Pages: X, 479 p. 77 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030846435
    Series Statement: Food Bioactive Ingredients,
    DDC: 664.001579
    Language: English
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  • 95
    Keywords: Medicine Research. ; Biology Research. ; Virology. ; Clinical medicine Research. ; Epidemiology. ; Public health. ; Biomedical Research. ; Virology. ; Clinical Research. ; Epidemiology. ; Public Health.
    Description / Table of Contents: Clinical features, diagnostic evaluation and management of COVID-19 patients -- Outbreak of COVID-19: A Detailed Overview and Its Consequences -- A paradigm gap in host-pathogen interaction studies: Lesson from the COVID-19 pandemic -- SARS/CoV-2: Behavioral Host Manipulation -- Management of COVID-19 in the Intensive Care Unit -- First wave of Covid-19 pandemic in Italy: data and evidence -- Risk factors for COVID-19: diabetes, hypertension and obesity -- Current challenges for the effective management of the COVID-19 pandemic -- COVID-19 Outbreak Challenges in Indian Migrant Pregnant and Lactating Mothers: Learnt Lesson Demands Phronesis and Hierarchical Strategies for Such Future Pandemics -- COVID-19 and Extracorporeal Membrane Oxygenation -- COVID-19's Clinical-Pathological Evidence in Relation to its Repercussion on the Central and Peripheral Nervous System -- Anatomopathological Aspects and Clinical Correlation of COVID-19: A Systematic Review -- SARS-CoV-2 liability: the hidden mystery behind its presentation in children.
    Abstract: The book Coronavirus Therapeutics Volume II provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 241 p. 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851132
    Series Statement: Advances in Experimental Medicine and Biology, 1353
    DDC: 610.72
    Language: English
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  • 96
    Keywords: Medicine Research. ; Biology Research. ; Virology. ; Clinical medicine Research. ; Epidemiology. ; Biomedical Research. ; Virology. ; Clinical Research. ; Epidemiology.
    Description / Table of Contents: Origin and structural biology of Novel Coronavirus (SARS-CoV-2) -- The Molecular Virology of Coronaviruses with Special Reference to SARS-CoV-2 -- Epidemiology, transmission and molecular immunopathology of SARS-CoV-2 -- Epidemiology and Etiopathogeny of Covid-19 -- Immunological and Hematological Response in COVID-19 -- Toll-like receptors (TLRs) as Therapeutic Targets for Treating SARS-CoV-2: An Immunobiological Perspective -- Potential drug strategies to target Coronaviruses -- Possible therapeutic intervention strategies for COVID-19 by manipulating the cellular proteostasis network -- The potential impact of statins in the treatment of patients with COVID-19 infection -- Anticoronavirus activity of water-soluble pristine C60 fullerenes: in vitro and in silico screening -- Application of Nanoscale materials and nanotechnology against viral infection: A special focus on Coronaviruses -- Obesity: A Risk Factor for Covid-19 -- Cytokine Storm and Failed Resolution in COVID-19: Taking Cue from Multiple Sclerosis.
    Abstract: The book Coronavirus Therapeutics Volume I provides the most comprehensive review on contemporary knowledge on the origin, structural biology and molecular aspects of Coronaviruses. It also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 222 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851095
    Series Statement: Advances in Experimental Medicine and Biology, 1352
    DDC: 610.72
    Language: English
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  • 97
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biomechanics. ; Biotechnology. ; Biomedical engineering. ; Regenerative medicine. ; Biomechanics. ; Biotechnology. ; Biomedical Engineering and Bioengineering. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: 1 Modeling in Biomechanics 1 -- 1.1 The different perspectives 2 -- 1.1.1 The engineering approach 2 -- 1.1.2 The clinical approach 2 -- 1.1.3 The pre- clinical approaches 2 -- 1.2 Opportunities and challenges 2 -- 1.3 Statistical analysis 3 -- 1.3.1 Probability distributions 4 -- 1.3.2 Hypothesis testing 7 -- 1.3.3 Correlation amongst variables 9 -- 1.3.4 Regression modeling 10 -- 1.3.5 Mean difference test 13 -- 1.3.6 Study design 14 -- 1.4 Model definition 16 -- 1.5 Model development and testing 17 -- 1.5.1 Sensitivity analysis 17 -- 1.5.3 Validation 21 -- 1.6 Case study: Biomechanical Rupture Risk Assessment (BRRA) 21 -- 1.6.1 Short comings of the current AAA risk assessment 21 -- 1.6.2 Intended Model Application (IMA) 21 -- 1.6.3 Failure hypothesis 22 -- 1.6.4 Work flow and diagnostic information 22 -- 1.6.5 Key modeling assumptions 23 -- 1.6.6 Clinical validation 24 -- 1.7 Summary and conclusion 25 -- Appendix: Biomechanics Modeling 27 -- A.1 Definitions and terminology in statistics 27 -- 2 The circulatory system 29 -- 2.1 Physiology 29 -- 2.1.1 Vascular system 29 -- 2.1.2 Key concepts 31 -- 2.1.3 Cells in the vascular system 32 -- 2.1.4 Macrocirculation 33 -- 2.1.5 Lymphatic system 37 -- 2.1.6 Microcirculation 38 -- 2.1.7 Hemodynamic regulation 41 -- 2.2 Mechanical system properties 42 -- 2.2.1 Vascular pressure 43 -- 2.2.2 Vascular flow 44 -- 2.2.3 Vascular resistance 45 -- 2.2.4 Transcapillary transport 45 -- 2.3 Modeling the macrocirculation 45 -- 2.3.1 Windkessel (WK) models 46 -- 2.3.2 Vessel network modeling 57 -- 2.4 Modeling the Microcirculation 63 -- 2.4.1 Transcapillary concentration difference 63 -- 2.4.2 Filtration 65 -- 2.5 Summary and conclusion 70 -- Appendix: Mathematical preliminaries 72 -- A.1 Complex numbers 72 -- A.2 Fourier series approximation 72 -- Appendix: Basic circuit elements 73 -- B.1 Resistor element 73 -- B.2 Capacitor element 73 -- B.3 Inductor element 74 -- Appendix: Transport mechanisms 74 -- C.1 Diffusion 74 -- C.2 Advection 75 -- Appendix: Osmosis 75 -- D.1 Osmotic pressure 75 -- D.2 Transport across semipermeable membranes 76 -- 3 Continuum Mechanics 77 -- 3.1 Kinematics 78 -- 3.1.1 Deformation gradient 78 -- 3.1.2 Multiplicative decomposition 79 -- 3.1.3 Polar decomposition 79 -- 3.1.4 Deformation of the line element 79 -- 3.1.5 Deformation of the volume element 80 -- 3.1.6 Deformation of the area element 80 -- 3.1.7 Concept of strain 81 -- 3.2 Concept of stress 85 -- 3.2.1 Cauchy stress theorem 86 -- 3.2.2 Principal stresses 87 -- 3.2.3 Isochoric and volumetric stress 89 -- 3.2.4 Octahedral stress and von Mises stress 89 -- 3.2.5 Cauchy stress in rotated coordinates 91 -- 3.2.6 First Piola-Kirchhoff stress 91 -- 3.2.7 Second Piola-Kirchhoff stress 92 -- 3.2.8 Implication of material incompressibility on the stress state 93 -- 3.3 Material time derivatives 94 -- 3.3.1 Kinematic variables 94 -- 3.3.2 Stress rates 95 -- 3.3.3 Power-conjugate stress and strain rates 96 -- 3.4 Constitutive modeling 97 -- 3.4.1 Some mechanical properties of materials 97 -- 3.4.2 Linear elastic material 100 -- 3.4.3 Hyperelasticity 102 -- 3.4.4 Viscoelasticity 105 -- 3.5 Governing laws 113 -- 3.5.1 Mass balance 114 -- 3.5.2 Balance of linear momentum 116 -- 3.5.3 Maxwell transport and localization 118 -- 3.5.4 Thermodynamic principles 119 -- 3.6 General principles 125 -- 3.6.1 Free body diagram 125 -- 3.6.2 Initial Boundary Value Problem 126 -- 3.6.3 Principle of Virtual -- 3.7 Damage and failure 129 -- 3.7.1 Physical consequences 129 -- 3.7.2 Strain localization 130 -- 3.7.3 Linear Fracture Mechanics 132 -- 3.7.4 J -- Integral 133 -- 3.7.5 Cohesive zone modeling 133 -- 3.8 Multiphasic continuum theories 134 -- 3.8.1 Mixture theory 134 -- 3.8.2 Poroelasticity theory 134 -- 3.9 Summary and conclusion 135 -- Appendix: Mathematical preliminaries 136 -- A.1 Laplace and Fourier transforms 136 -- A.2 Matrix algebra 136 -- A.2.1 Trace of a matrix 137 -- A.2.2 Identity matrix 137 -- A.2.3 Determinant of a matrix 137 -- A.2.4 Inverse and orthogonal matrix 138 -- A.2.5 Linear vector transform 138 -- A.2.6 Eigenvalue problem 138 -- A.2.7 Relation between the trace and the eigenvalues 139 -- A.2.8 Cayley-Hamilton theorem 139 -- A.3 Vector algebra 140 -- A.3.1 Basic vector operations 140 -- A.3.2 Coordinate transformation 142 -- A.4 Tensor algebra 144 -- A.4.1 Spherical tensor 144 -- A.4.2 Tensor operations 145 -- A.4.3 Invariants of second-order tensors 145 -- A.5 Vector and tensor calculus 146 -- A.5.1 Local changes of field variables 146 -- A.5.2 Divergence theorem 147 -- Appendix: Some useful Laplace and Fourier transforms 148 -- B.1 Laplace transforms 148 -- B.2 Fourier transforms 150 -- Appendix: Some useful tensor relations 151 -- 4 Conduit vessels 153 -- 4.1 Histology and morphology of the vessel wall 154 -- 4.1.1 Layered vessel wall organization 154 -- 4.1.2 Differences between arteries and veins 155 -- 4.1.3 Extra Cellular Matrix (ECM) 156 -- 4.1.4 Cells 157 -- 4.2 Mechanical properties and experimental observations 158 -- 4.2.1 Aorta 160 -- 4.2.2 Carotid artery 161 -- 4.2.3 Coronary artery 162 -- 4.2.4 Iliac artery 163 -- 4.3 Vascular diseases 163 -- 4.3.1 Diagnostic examinations 164 -- 4.3.2 Atherosclerosis 165 -- 4.3.3 Biomechanical factors in atherosclerosis 167 -- 4.3.4 Carotid artery disease 169 -- 4.3.5 Coronary heart disease 171 -- 4.3.6 Aneurysm disease 172 -- 4.4 Vascular adaptation 174 -- 4.5 Constitutive descriptions 175 -- 4.5.1 Capacity of a vessel segment 176 -- 4.5.2 Hyperelasticity for incompressible solids 177 -- 4.5.3 Purely phenomenological descriptions 178 -- 4.5.4 Histo-mechanical descriptions 183 -- 4.5.5 General theory of fibrous connective tissue 185 -- 4.5.6 Residual stress and load -- free configuration 188 -- 4.5.7 Visco-elastic descriptions 189 -- 4.5.8 Damage and failure descriptions 191 -- 4.5.9 Non-passive vessel wall properties 194 -- 4.6 Identification of constitutive parameters 194 -- 4.6.1 Analytical vessel wall models 197 -- 4.6.2 Optimization problem 199 -- 4.7 Case study: Wall stress analysis of the normal and aneurysmatic -- infrarenal aorta 205 -- 4.7.1 the analysis type 205 -- 4.7.2 Setting the boundary conditions- Dirichlet boundary 205 -- 4.7.3 Setting the loading conditions - Neuman boundary 205 -- 4.7.4 Setting the vascular wall properties 206 -- 4.7.5 Setting the output options 206 -- 4.8 Summary and Conclusion 206 -- Appendix: Protocol experimental vessel wall testing 208 -- A.1 Tissue harvesting and sample preparation 208 -- A.2 Test protocol definition and data recording 208 -- A.3 Acquired -- x CONTENTS -- 5 Blood flow 211 -- 5.1 Blood composition 211 -- 5.1.1 Erythrocyte (or red blood cell) 212 -- 5.1.2 Leukocyte (or white blood cell) 212 -- 5.1.3 Thrombocyte (or platelet) 213 -- 5.1.4 Plasma 213 -- 5.2 Forces acting at blood particles 214 -- 5.2.1 Drag force 214 -- 5.2.2 Gravitational and inertia forces 214 -- 5.2.3 Forces related to fluid pressure 214 -- 5.2.4 Forces related to fluid velocity and shear stress 215 -- 5.2.5 Forces arising from collisions 216 -- 5.2.6 Chemical and electrical forces 216 -- 5.2.7 Segregation of blood particles 218 -- 5.3 Blood rheology modeling 218 -- 5.3.1 Alteration of blood microstructure with the shear rate 218 -- 5.3.2 Modeling generalized Newtonian fluids 219 -- 5.3.3 Single-phase viscosity models for blood 220 -- 5.3.4 Composition-based viscosity models for blood 221 -- 5.4 Blood damage 224 -- 5.5 Description of incompressible flows 224 -- 5.5.1 Energy conservation 224 -- 5.5.2 Linear momentum conservation 226 -- 5.6 Blood flow phenomena 232 -- 5.6.1 Laminar and turbulent flow 232 -- 5.6.2 Boundary layer flow 233 -- 5.6.3 Blood flow through circular tubes 233 -- 5.6.4 Multi-dimensional flow phenomena 234 -- 5.7 Case study: Wall Shear Stress (WSS) analysis of the normal and -- aneurysmatic infrarenal aorta 236 -- 5.7.1 Setting the analysis type 236 -- 5.7.2 Setting the boundary conditions -Dirichlet boundary 236 -- 5.7.3 Setting the loading conditions -Neuman boundary 237 -- 5.7.4 Setting the blood rheological properties 237 -- 5.7.5 Setting the output options 237 -- 5.8 Summary and conclusion 238 -- Appendix: Mathematical preliminaries 239 -- 6 The vascular wall, an active entity 241 -- 6.1 Vasoreactivity 242 -- 6.1.1 Structure of contractile SMC 242 -- 6.1.2 SMC contraction regulation 243 -- 6.2 Arteriogenesis 243 -- 6.3 Angiogenesis 244 -- 6.4 Damage, healing and failure 244 -- 6.5 Modeling frameworks 244 -- 6.5.1 Open system governing laws 245 -- 6.5.2 Kinematics-based growth description 246 -- 6.5.3 Tensorial distribution of volume growth 248 -- 6.5.4 Homeostatic growth 249 -- 6.5.5 Continues turnover-based growth description 252 -- 6.5.6 Other formulations 256 -- 6.5.7 Applications of growth descriptions 257 -- 6.6 Conclusion and Discussion 258 -- 6.7 Applications 259 -- 6.7.1 Tensile testing the passive and active vessel wall 259 -- 6.7.2 Biaxially loaded vessel wall patch 260 -- 6.7.3 Ring testing of vessel segments 262 -- References 265 -- Problem Solutions 287 -- Index 373.
    Abstract: This textbook serves as a modern introduction to vascular biomechanics and provides the comprehensive overview of the entire vascular system that is needed to run successful vascular biomechanics simulations. It aims to provide the reader with a holistic analysis of the vascular system towards its biomechanical description and includes numerous fully through-calculated examples. Various topics covered include vascular system descriptions, vascular exchange, blood vessel mechanics, vessel tissue characterization, blood flow mechanics, and vascular tissue growth and remodeling. This textbook is ideally suited for students and researchers studying and working in classical and computational vascular biomechanics. The book could also be of interest to developers of vascular devices and experts working with the regulatory approval of biomedical simulations. Follows the principle of “learning by doing” and provides numerous fully through-calculated examples for active learning, immediate recall, and self-examination; Provides a holistic understanding of vascular functioning and the integration of information from different disciplines to enable students to use sophisticated numerical methods to simulate the response of the vascular system; Includes several case studies that integrate the presented material. Case studies address problems, such as the biomechanical rupture risk assessment of Abdominal Aortic Aneurysms, Finite Element analysis of structural and blood flow problems, the computation of wall stress and wall shear stress in the aorta.
    Type of Medium: Online Resource
    Pages: XXIII, 608 p. 283 illus., 271 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030709662
    DDC: 571.43
    Language: English
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  • 98
    Keywords: Botany. ; Ecology . ; Conservation biology. ; Botanical chemistry. ; Plant physiology. ; Pharmacology. ; Plant Science. ; Ecology. ; Conservation Biology. ; Plant Biochemistry. ; Plant Physiology. ; Pharmacology.
    Description / Table of Contents: Part I: Ecological and Evolutionary pathways -- Chapter 1: The Ecological and Applied Potential of Baccharis -- Chapter 2: Baccharis: Diversity and Distribution -- Chapter 3: The Evolution of Genetic Studies of Baccharis -- Chapter 4: Intersexual Differences in Demography, Resource Investment, and Herbivory in Baccharis -- Chapter 5: Multitrophic and Indirect Interactions in the Baccharis dracunculifolia System -- Chapter 6: Endophytic Fungi of Baccharis -- Chapter 7: Baccharis as Nurse Plants -- Chapter 8: Biological Invasion by Baccharis -- Part II: Structure and Chemistry of Baccharis -- Chapter 9: Morpho-anatomical Characteristics of Species of Baccharis -- Chapter 10: Essential Oils of Baccharis: Chemical Composition and Biological Activities -- Chapter 11: Flavonoids of Baccharis -- Chapter 12: Chemistry and Biological Activities of Phenolic Compounds from Baccharis Genus -- Chapter 13: Baccharis Terpenoid Compounds -- Chapter 14: Macrocyclic Trichothecenes of Baccharis -- Chapter 15: Livestock Intoxication by Baccharis -- Part III: Baccharis: Applications and Innovations -- Chapter 16: An Overview of the Cultural and Popular Use of Baccharis -- Chapter 17: CPQBA 1: First Cultivar Registered and Protected From a Brazilian Medicinal Plant -- Chapter 18: Perspectives of Baccharis Secondary Metabolites as Sources for New Anticancer Drug Candidates -- Chapter 19: Innovation and Knowledge of Prospective Studies on the Genus Baccharis -- Part IV: Propolis of Baccharis -- Chapter 20: Chemical Constituents and Antioxidant Properties of Green Propolis -- Chapter 21: Possible Role of Propolis-derived Components in the Prevention and Treatment of Obesity and Diabetes -- Chapter 22: Effects of the Green Propolis on the Immune Response -- Chapter 23: From Innovation to Market: an Analysis of the Propolis Production Chain.
    Abstract: This book has a broad scope and provides a comprehensive overview of the most up-to-date knowledge of the plant genus Baccharis. The book is organized into four major topics encompassing the evolution, ecology, chemistry, as well as environmental and medical applications of the genus. This publication is a major reference for an audience of practising researchers, academics, PhD students, and other scientists in a wide-ranging collection of fields, from Sociology to Medicine to bioeconomy.
    Type of Medium: Online Resource
    Pages: XIX, 578 p. 137 illus., 79 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030835118
    DDC: 580
    Language: English
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  • 99
    Keywords: Proteins. ; Immunology. ; Medical microbiology. ; Diseases. ; Cancer. ; Proteins. ; Immunology. ; Medical Microbiology. ; Diseases. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Chemically synthesized TLR4 ligands, their immunological functions and potential as vaccine adjuvant -- Chapter 2. Intracellular TLR4 signaling -- Chapter 3. TLR4 Ligands: Single Molecules and Aggregates -- Chapter 4. CD14: not just chaperone, but a key-player in inflammation -- Chapter 5. Toll-Like Receptor 4 interactions with Neisseria -- Chapter 6. Toll-Like Receptor4 and Damage-Associated Molecular Patterns (DAMPS) -- Chapter 7. TLR4 in neurodegenerative diseases: Alzheimer and Parkinson disease -- Chapter 8. TLR4-mediated Neuroinflammation in Human Induced Pluripotent Stem Cells and Cerebral Organoids -- Chapter 9. The role of TLR4 in neural stem cells-mediated neurogenesis and neuroinflammation -- Chapter 10. Toll-Like Receptor 4 and the world of microRNAs -- Chapter 11. Metabolic reprogramming of myeloid cells upon TLR4 stimulation.
    Abstract: TLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs). This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade. The book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer’s diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4. .
    Type of Medium: Online Resource
    Pages: XI, 174 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030563196
    Series Statement: Progress in Inflammation Research, 87
    DDC: 572.6
    Language: English
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  • 100
    Keywords: Neurosciences. ; Anatomy. ; Internal medicine. ; Neuroscience. ; Anatomy. ; Internal Medicine.
    Description / Table of Contents: PART I. Glial-Neuronal Interactions in the Control of Hypothalamic Development -- The Role of Microglia in the Developing Hypothalamus -- PART II. Glial-Neuronal Interactions in the Control of the Magnocellular Neuroendocrine System -- Functional Consequences of Morphological Plasticity in the Adult Hypothalamo-Neurohypophysial System -- Fenestrated Capillary and Dynamic Neuro-Glial-Vascula Reorganization of the Adult Neurohypophysis -- Astrocyte-Magnocellular Neuron Interactions in Hypothalamic Memory -- The Multifaceted Roles of Hypothalamic Astrocytes and Microglial Cells in Neuroendocrine and Autonomic Regulation in Health and Disease -- PART III. Gial-Neuronal Interactions in the Control of Metabolic Function -- Control of Systemic Metabolism by Astrocytes in the Brain -- Glia-Neuron Communication: Not a One-way Street -- PART IV. Glial-Neuronal Interactions in the Control of the Stress Response -- Retrograde Signaling Via Dendritic Activation of Glial-Neuronal Circuits -- PART V. Glial-Neuronal Interactions in the Control of Reproductive Function -- Microglia, Hormones, and Behavior -- Hypothalamic Astrocytes and the Role of Neuroprogesterone in Estrogen Positive Feedback -- PART VI. Glial-Neuronal Interactions that Link Brain and Periphery -- Unveiling the Importance of Tanycytes in the Control of the Dialogue Between the Brain and the Periphery -- Tanycyte Regulation of Hypophysiotropic TRH Neurons.
    Abstract: This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 324 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030623838
    Series Statement: Masterclass in Neuroendocrinology, 11
    DDC: 612.8
    Language: English
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