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  • R5-920  (734)
  • thema EDItEUR::C Language and Linguistics::CF Linguistics  (645)
  • 550 - Earth sciences
  • Chemistry
  • 2020-2024  (1,386)
  • 2015-2019
  • 2005-2009
  • 1985-1989
  • 2021  (1,386)
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  • 1
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    Electrospun and Electrosprayed Formulations for Drug Delivery (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
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    Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
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    Neuroimmune Interface in Health and Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 4
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    Die Sprache des Artakserksovo dejstvo (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Die Arbeit besteht somit aus zwei Hauptteilen. Zunächst werden in den "Vorbemerkungen" die wichtigsten Begriffe gegeneinander abgegrenzt und ein Forschungsüberblick gegeben. Da die Entwicklung der russischen Sprache eng mit den jeweiligen geschichtlichen Ereignissen verknüpft ist, werden im ersten, mehr referierenden Teil die geschichtlichen Voraussetzungen für den Sprachwandel in einem kurzen Überblick dargelegt. Anschließend wird die sprachliche Umbruchsituation charakterisiert. Einen eigenen Abschnitt wird dabei die Einordnung des "Artakserksovo dejstvo" in den literarischen Kontext seiner Zeit bilden. Im zweiten Teil wird der Text des "Artakserksovo dejstvo" sprachlich untersucht.
    Keywords: Artakserksovo ; ausgehenden ; dejstvo ; Jahrhunderts ; Rußland ; Schellenberger ; Situation ; Sprache ; sprachlichen ; Studien ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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  • 5
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    Der Imperativsatz im Slowakischen mit Blick auf andere westslawische Sprachen (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: The aim of this work is to integrate the West Slavic languages ​​into grammar and language comparisons using modern grammatical approaches. This is done using the example of the imperative sentence in Slovak with a view to other West Slavic languages. This type of sentence is examined for its formal and content-related characteristics. At the same time, its communicative-pragmatic potential is derived and explained from the structural meaning of this mode verbi. The demarcation between the grammar and the pragmatics of the imperative theorem will play an important role here.
    Description: Das Ziel dieser Arbeit ist es, die westslawischen Sprachen unter Anwendung moderner grammatiktheoretischer Ansätze in den Grammatik- und Sprachvergleich zu integrieren. Dies erfolgt am Beispiel des Imperativsatzes im Slowakischen mit Blick auf andere westslawische Sprachen. Dieser Satztyp wird hinsichtlich seiner formalen und inhaltlichen Eigenschaften untersucht. Zugleich wird sein kommunikativ-pragmatisches Potential aus der Strukturbedeutung dieses Modus verbi abgeleitet und erklärt. Dabei wird die Grenzziehung zwischen der Grammatik und der Pragmatik des Imperativsatzes eine wichtige Rolle spielen.
    Keywords: Blick ; Grammatik ; grammatiktheoretisch ; Imperativsatz ; Linguistik ; Pragmatik ; Satztyps ; Semantik ; Slavische Sprachwissenschaft ; Slowakischen ; Späth ; Sprachen ; Strukturbedeutung ; Syntax ; westslawische ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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  • 6
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    Recursos Críticos: história da cooperação técnica Opas-Brasil em recursos humanos para a saúde (1975-1988) (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Um livro valioso, que analisa com clareza o papel fundamental dos recursos humanos para a saúde e o desenvolvimento, bem como o contexto e o impacto da reforma sanitária e a relação entre as iniciativas internacionais, nacionais e locais em prol da mudança dos serviços de saúde. Além de examinar os antecedentes e os principais atores da área de recursos humanos e explicar com detalhes as negociações que visavam transformar em prioridade nacional a formação de recursos humanos e a distribuição dos trabalhadores de saúde no território, Recursos Críticos está apoiado em uma sólida pesquisa bibliográfica, testemunhos fascinantes e análise original, que fazem da obra uma contribuição significativa no campo da memória da saúde pública e uma ferramenta indicativa de perspectivas de futuro para trabalhadores na área da saúde. É uma pesquisa histórica de grande qualidade, voltada para a análise da cooperação Opas-Brasil, e um incentivo à realização de novos estudos sobre as interfaces entre a atuação de agências internacionais e os interesses nacionais, partindo do conceito de arenas ou espaços de negociação.
    Keywords: R5-920 ; Brasil ; Recursos humanos em saúde ; Planos e programas de saúde ; Cooperação técnica ; Organização Pan-Americana da Saúde ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 7
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    A Reader in Slovak Linguistics (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉The authors of the articles are Slovak linguists who work within various spheres of linguistics. Represented in the volume are authors who started their scientific activity in the pre-war period, directly or indirectly building on the work of the Prague Linguistic Circle, but soon differentiating themselves and contributing to linguistic theory with original works, as well as a newer generation of linguists who entered linguistics within the last two decades. 〈/P〉
    Keywords: Kacala ; Linguistics ; Linguistik ; Prague Linguistic Circle ; pre-war period ; Reader ; Semantics ; Slavische Sprachwissenschaft ; Slovak ; Slovak linguists ; Studies ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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  • 8
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    České stupňování (2021)
    Peter Lang International Academic Publishing Group
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    Publication Date: 2024-03-24
    Description: 〈P〉Die 1972 von den Frankfurter Slavisten Olexa Horbatsch und Gerd Freidhof begründete Reihe Specimina philologiae Slavicae wird heute von Holger Kuße (Dresden), Peter Kosta (Potsdam), Beatrix Kreß (Hildesheim), Franz Schindler (Gießen), Barbara Sonnenhauser (Zürich) und Nadine Thielemann (Wien) herausgeben. In der Reihe erscheinen Monographien, Sammelbände und Lehrbücher zu allen Gebieten der Slavistik, der Sprach-, der Literatur- und der Kulturwissenschaft. In der Sprachwissenschaft erscheinen sowohl sprachhistorische als auch innovative Arbeiten zur Pragmatik und Semantik, zu slavischen Kleinsprachen und zur Diskurslinguistik. In der Literatur- und Kulturwissenschaft gehört zu den besonderen Interessensgebieten die Russische Philosophie.〈/P〉
    Keywords: České ; comparison ; Czech ; Degrees ; Linguistik ; Literatur ; Marvan ; Philologie ; Slawistik ; Sprachwissenschaft ; stupňování ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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  • 9
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    Inhibiting PARP as a Strategic Target in Cancer (2021)
    Frontiers Media SA
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    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 10
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    International Perspectives on Health and Safety Among Dairy Workers Challenges, Solutions and the Future (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 11
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    From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders；celiac disease；gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 12
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    Microglia in Health and Disease: A Unique Immune Cell Population (2021)
    Frontiers Media SA
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    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    HLA-G-mediated Immune Tolerance: Past and New Outlooks (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 14
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    Nach der Einsprachigkeit (2021)
    Peter Lang International Academic Publishing Group
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    Publication Date: 2024-03-24
    Description: Postkoloniale Konstellationen lassen sich nicht (mehr) in das Eigene und das Andere, in das Originäre und das Nachgeahmte, in ein Hier und Dort auseinanderdividierenden. Sie sind geprägt von Verflechtungen, Hybri-disierungen und wechselseitigen Aneignungsprozessen. In diesem Band analysiert die Autorin Texte von Jurij Brězan, Irena Brežná, Mascha Dabić, Róža Domašcyna, Olga Grjasnowa, Barbi Marković, Olga Martynova und Aleksandar Tišma. Sie zeigt auf, dass alle Werke sich mit multiplen Zuge-hörigkeiten, Mehrsprachigkeit und Übersetzung auseinandersetzen. Die Texte dekonstruieren Grenzen sprachlicher und kultureller Zugehörigkeit, thematisieren aber auch Diskriminierung, Rassismus und Antisemitismus. Damit beschreiben sie mehrsprachige Welten jenseits von hegemonialer Einsprachigkeit.
    Keywords: Aleksandar Tišma ; Barbi Marković ; deutsche ; Einsprachigkeit ; Hitzke ; Jurij Brězan ; Mehrsprachigkeit ; Olga Grjasnowa ; Olga Martynova ; Postkoloniale Literatur ; Slavisch ; Sorbische Literatur ; Texte ; transkulturell ; Übersetzung ; Verflechtung ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Language: German
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    Mechanical Loading and Bone (2021)
    Frontiers Media SA
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    Publication Date: 2022-01-31
    Description: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Keywords: RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
    Language: English
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    Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer (2021)
    Frontiers Media SA
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    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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    Transmucosal Absorption Enhancers in the Drug Delivery Field (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
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    Очерки по истории и культуре староверов Эстонии III [Studies on the history and culture of Old Believers in Estonia III] (2021)
    University of Tartu Press
    Details
    Publication Date: 2024-03-23
    Description: Acta Slavica Estonica is an international series of publications on current issues of Russian and other Slavic languages, literatures and cultures. This volume continues the tradition of publishing studies on the history and culture of the Old Believers in Estonia. It includes research papers on the topic, as well as transcripts of recorded texts from the Old Believers. The special focus of the volume is on the island Piirissaar, its history, architecture, people and their language, customs and traditions.
    Keywords: cultural studies ; Slavic studies ; Russian linguistics ; Russian dialects ; Russian onomastics ; folklore ; Russian lexicology ; old believers ; idiolects ; thema EDItEUR::1 Place qualifiers::1D Europe::1DT Eastern Europe::1DTE Estonia ; thema EDItEUR::2 Language qualifiers::2A Indo-European languages::2AG Slavic (Slavonic) languages::2AGR Russian ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups::QRMB2 Orthodox and Oriental Orthodox Churches ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBG Popular beliefs and controversial knowledge::JBGB Folklore studies / Study of myth (mythology) ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSC Rural communities ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies::JBSL1 Ethnic groups and multicultural studies
    Language: Russian , Estonian
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    Eine semantische Analyse der Perfektivierungspraefigierung im Russischen. Fallstudie pere- (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: The work consists of two parts. The first part deals exclusively with the aspect properties of Russian prefigured verbs. A perfective analysis for Russian is proposed, which allows to grasp the semantic differences between imperfective Simplizia and its derivative derivatives in semantic terms. The second part of the thesis is an application of the proposed perfective analysis to Russian pere-prefixed verbs. It is shown that the meaning variants of pere-prefixed verbs in Russian can be derived from a general prefix scheme and the semantics of the stem verb.
    Description: Die Arbeit besteht aus zwei Teilen. Der erste Teil befaßt sich ausschließlich mit den aspektuellen Eigenschaften russischer präfigierter Verben. Es wird eine Perfektivanalyse für das Russische vorgeschlagen, die es ermöglicht, die semantischen Unterschiede zwischen imperfektiven Simplizia und ihren perfektiven Derivata in semantischen Termen zu erfassen. Der zweite Teil der Arbeit stellt eine Anwendung der vorgeschlagenen Perfektivanalyse auf russische pere-präfigierte Verben dar. Es wird gezeigt, daß die Bedeutungsvarianten pere-präfigierter Verben im Russischen aus einem allgemeinen Präfixschema und der Semantik des Stammverbs abgeleitet werden können.
    Keywords: Analyse ; Demjjanow ; Eine ; Fallstudie ; imperfektives Simplizia ; pere ; Perfektivaxiome ; Perfektivierung im Lexikon ; Perfektivierungspräfigierung ; Perfektiv-Imperfektivtest ; Russischen ; semantische ; Verbpräfigierung ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Die Entstehung des slavischen phonologischen Systems und seine Entwicklung bis zum Ende der Periode der slavischen Spracheinheit (2021)
    Peter Lang International Academic Publishers
    Details
    Publication Date: 2024-03-24
    Description: In der Reihe Slavistische Beiträge werden vor allem slavistische Dissertationen des deutschsprachigen Raums sowie vereinzelt auch amerikanische, englische und russische publiziert. Darüber hinaus stellt die Reihe ein Forum für Sammelbände und Monographien etablierter Wissenschafter/innen dar.
    Keywords: Ende ; Entstehung ; Entwicklung ; Linguistik ; Mareš ; Periode ; Philologie ; phonologischen ; Russland ; seine ; Slavische Sprachwissenschaft ; slavischen ; Spracheinheit ; Systems ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Hramatika slovenska (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Die Beschäftigung mit den sprachlichen Merkmalen der Gennadius-Bibel (1499) und Ostroger Bibel (1580/81) hat die Herausgabe der Zizanij-Grammatik (1596), der ersten umfangreicheren Abhandlung über die kirchenslavische Sprache bei den Ostslaven, sinnvoll und wünschenswert erscheinen lassen. Sie stellt sowohl durch den normativen Charakter im grammatikalische Teil als auch durch die staken Einflüsse der Volkssprache in den vorausgehenden und nachfolgenden Teilen ein interessantes Denkmal der letzten Dekade des 16.Jh. dar.
    Keywords: Hramatika ; kirchenslavische Grammatik ; kirchenslavische Sprache ; Linguistik ; Ostroger Bibel ; slavische Sprachwissenschaft ; slovenska ; Zizanij-Grammatik ; Zyzanij ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Slovenian
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    Die Funktion des Verbalaspekts im Praesens historicum des Russischen (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉In der Reihe 〈I〉Slavistische Beiträge〈/I〉 werden vor allem slavistische Dissertationen des deutschsprachigen Raums sowie vereinzelt auch amerikanische, englische und russische publiziert. Darüber hinaus stellt die Reihe ein Forum für Sammelbände und Monographien etablierter Wissenschafter/innen dar.〈/P〉
    Keywords: Funktion ; historicum ; Linguistik ; Panzer ; Philologie ; Praesens ; Russischen ; Russland ; Slavische Sprachwissenschaft ; Sprachwissenschaft ; Verbalaspekts ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    L. N. Tolstoj i T. M. Bondarev. Perepiska. 1885-1898 (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: The series Lectures and Treatises on Slavic Studies, which has been published since 1980, offers opportunities for publication, especially for smaller monographs, which, in terms of their scope, are located between the journal article and the large book. It will cover topics from the whole area of ​​Slavic languages, literatures and cultures as well as their interrelations. In addition to investigations, bibliographies, research reports and editions are published. The authors of the previous volumes come from America, Canada, Germany, Finland, Poland, Russia, Switzerland, Slovenia, the Czech Republic and Hungary.
    Description: Die seit 1980 erscheinende Reihe Vorträge und Abhandlungen zur Slavistik bietet Publikationsmöglichkeiten vor allem für kleinere Monographien, die ihrem Umfang nach zwischen Zeitschriftenbeitrag und großem Buch anzusiedeln sind. Aufgenommen werden Themen aus dem Gesamtbereich der slavischen Sprachen, Literaturen und Kulturen sowie ihrer Wechselbeziehungen. Neben Untersuchungen werden auch Bibliographien, Forschungsberichte und Editionen veröffentlicht. Die Autoren und Autorinnen der bisherigen Bände kommen aus Amerika, Kanada, Deutschland, Finnland, Polen, Rußland, Schweiz, Slowenien, Tschechische Republik und Ungarn.
    Keywords: 1885 ; 1898 ; Bondarev ; Briefe ; Donskov ; Erinnerungen ; Literaturwissenschaft ; Perepiska ; Russland ; Tagebücher ; Tolstoj ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    A aquisição de língua materna e não materna (2021)
    Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: The present volume is an introduction to the study of Language Acquisition, especially centered on Portuguese. Even though the different chapters always take Portuguese as a point of departure, a comparative perspective is assumed and Portuguese data is compared to data from other languages, when relevant. This book aims at filling a gap in the literature: an introductory textbook to be used by students of Language Acquisition in Portuguese-speaking countries. The book is composed by chapters authored by several Portuguese and Brazilian researchers and it presents in textbook format a relevant part of the research results obtained during the last decades. The book starts with a general historical presentation of the field. The following chapters explore the acquisition of phonology and syntax and consider the problem of typical and atypical development, as well as linguistic assessment. Bilingualism and L2 acquisition are the topics of two independent chapters. Two final chapters discuss the development of linguistic awareness, in relation to the acquisition of writing.
    Keywords: language acquisition ; bilingualism ; acquisition of syntax ; textbook ; linguistic assessment ; l2 acquisition ; acquisition of phonology ; portugese ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Miscellaneous languages
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    Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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    How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
    Language: English
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    Zur Vitalitaet slavischer Idiome in Deutschland (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Germany has gradually become Europe's largest immigration country and is increasingly shaped by the image of a multicultural and multilingual society. However, the issue of multilingualism receives little attention, especially with regard to Slavic migration idioms. The aim of the present study is the empirical investigation of the current language behavior of Slavophone immigrants and the determination of the vitality of their native languages. On the basis of a nationwide survey of 500 immigrants detailed microsociological data on the use of Slavic languages ​​depending on persons, topics and situations will be collected and the influence of linguistic ecological factors such as attitudes, motivations, identity and social network of speakers on language use and language content will be investigated. In addition, on the basis of interdisciplinary approaches to the description of linguistic minorities, the vitality of slavins is analyzed comparatively, showing the current situation and the future development of Slavia in Germany in general and specific tendencies of ethnolects in particular.
    Description: Deutschland hat sich sukzessive zum größten Einwanderungsland Europas entwickelt und wird immer stärker vom Bild einer multikulturellen und multilingualen Gesellschaft geprägt. Dem Thema Mehrsprachigkeit aber wird insbesondere in Bezug auf slavische Migrationsidiome nur wenig Beachtung geschenkt. Ziel der vorliegenden Studie ist die empirische Erforschung des aktuellen Sprachverhaltens slavophoner Immigranten und die Bestimmung der Vitalität ihrer Muttersprachen. Anhand einer deutschlandweiten Enquete unter 500 Zuwanderern werden detaillierte mikrosoziologische Daten zum Gebrauch der slavischen Sprachen in Abhängigkeit von Personen, Themen und Situationen erhoben und der Einfluss sprachökologischer Faktoren wie Attitüden, Motivationen, Identität und soziales Netzwerk der Sprecher auf die Sprachverwendung und den Spracherhalt untersucht. Zudem wird auf der Grundlage interdisziplinärer Ansätze zur Beschreibung von Sprachminderheiten die Vitalität der Slavinen komparativ analysiert, womit die gegenwärtige Situation und die zukünftige Entwicklung der Slavia in Deutschland im Allgemeinen und spezifische Tendenzen der Ethnolekte im Besonderen aufgezeigt werden.
    Keywords: Germany ; migration idioms ; immigration ; Achterberg ; Deutschland ; Ethnolinguistischen Vitalität ; Idiome ; Immigrantensprachen ; Immigration nach Deutschland ; Mehrsprachigkeit ; slavischer ; Sprachkontakt ; Vitalität ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Legitime Sprachen, legitime Identitäten (2021)
    transcript Verlag | transcript Verlag
    Details
    Publication Date: 2024-03-24
    Description: Das Einüben der Fähigkeit, mit sprachlicher und kultureller Vielfalt produktiv umzugehen, ist ein Kernanliegen des zeitgemäßen Fremdsprachenunterrichts. Doch wie ist der Umgang mit dieser im Klassenzimmer organisiert? Daniel H. Rellstab analysiert auf der Basis eines von Erving Goffman geprägten Interaktionsverständnisses Interaktionen in »Deutsch als Fremdsprache«-Klassenzimmern. Dabei zeigt er, welche Ressourcen Lehrkräfte sowie Schülerinnen und Schüler in der Interaktion einsetzen, wie sie aushandeln, welche Sprachen legitim, welche illegitim sind, und wie sie dabei Identitäten und Normen re- und dekonstruieren.
    Keywords: Deutsch Als Fremdsprache ; Interaktion ; Interaktionsanalyse ; Multimodalität ; Mehrsprachigkeit ; Legitimität ; Sprachkompetenz ; Spracherwerb ; Didaktik ; Lernen ; Identität ; Normensystem ; Sprache ; Bildung ; Gesellschaft ; Sprachwissenschaft ; Interkulturalität ; Germanistik ; Bildungsforschung ; Pädagogik ; German As a Foreign Language ; Interaction ; Interaction Analysis ; Multimodality ; Multilinguism ; Legitimacy ; Language Competence ; Language Acquisition ; Didactics ; Learning ; Identity ; Standard System ; Language ; Education ; Society ; Linguistics ; Interculturalism ; German Literature ; Educational Research ; Pedagogy ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Language: German
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    Chapter C10 Same Law, Different Texts (2021)
    Taylor & Francis | A Global History of Ideas in the Language of Law | Language and Law | Routledge
    Details
    Publication Date: 2024-03-24
    Description: Language plays an essential role both in creating law and in governing its implementation. Providing an accessible and comprehensive introduction to this subject, Language and Law:describes the different registers and genres that make up spoken and written legal language and how they develop over time; analyses real-life examples drawn from court cases from different parts of the world, illustrating the varieties of English used in the courtroom by speakers occupying different roles; addresses the challenges presented to our notions of law and regulation by online communication; discusses the complex role of translation in bilingual and multilingual jurisdictions, including Hong Kong and Canada; and provides readings from key scholars in the discipline, including Lawrence Solan, Peter Goodrich, Marianne Constable, David Mellinkoff, and Chris Heffer. With a wide range of activities throughout, this accessible textbook is essential reading for anyone studying language and law or forensic linguistics.
    Keywords: English for law ; English for specific purposes law ; forensic linguistics ; language and the law ; legal English ; legal genres ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::L Law::LA Jurisprudence and general issues ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAR Legal aspects of criminology ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAS Legal skills and practice
    Language: English
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    Recent advances in γδ T cell biology: New ligands, new functions, and new translational perspectives (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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    VIOT 2018 (2021)
    Amsterdam University Press
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    Publication Date: 2024-03-24
    Description: This book bundles 22 carefully selected contributions on recent research in language proficiency.
    Description: Dit boek bundelt 22 zorgvuldig geselecteerde bijdragen over recent onderzoek in de taalbeheersing.
    Keywords: Taalbeheersing ; communicatie ; onderzoek ; language proficiency ; communication ; research ; thema EDItEUR::C Language and Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Dutch
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    A grammar of Gyeli (Volume 2) (2021)
    Language Science Press | Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: This grammar offers a grammatical description of the Ngòló variety of Gyeli, an endangered Bantu (A80) language spoken by 4,000-5,000 "Pygmy" hunter-gatherers in southern Cameroon. It represents one of the most comprehensive descriptions of a northwestern Bantu language. The grammatical description, which is couched in a form-to-function approach, covers all levels of language, ranging from Gyeli phonology to its information structure and complex clauses. It draws on nineteen months of fieldwork carried out as part of the "Bagyeli/Bakola" DoBeS (Documentation of Endangered Languages) project between 2010 and 2014. The resulting multimodal corpus from that project, which includes texts of diverse genres such as traditional stories, narratives, multi-party conversations and dialogues, procedural texts, and songs, provides the empirical basis for the grammatical description. The documentary text collection, supplemented by data from elicitation work, questionnaires, and experiments, are accessible in the Bagyeli/Bakola collection of The Language Archive. With additional ethnographic, sociolinguistic, diachronic, and comparative remarks, the grammar may appeal to a wider audience in general linguistics, typology, Bantu studies, and anthropology. In 2019, the grammar received the Pāṇini Award by the Association for Linguistic Typology.
    Keywords: Language Arts & Disciplines ; Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Roots of language (2021)
    Language Science Press
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    Publication Date: 2024-03-24
    Description: Roots of language was originally published in 1981 by Karoma Press (Ann Arbor). It was the first work to systematically develop a theory first suggested by Coelho in the late nineteenth century: that the creation of creole languages somehow reflected universal properties of language. The book also proposed that the same set of properties would be found to emerge in normal first-language acquisition and must have emerged in the original evolution of language. These proposals, some of which were elaborated in an article in Behavioral and Brain Sciences (1984), were immediately controversial and gave rise to a great deal of subsequent research in creoles, much of it aimed at rebutting the theory. The book also served to legitimize and stimulate research in language evolution, a topic regarded as off-limits by linguists for over a century. The present edition contains a foreword by the author bringing the theory up to date; a fuller exposition of many of its aspects can be found in the author’s most recent work, More than nature needs (Harvard University Press, 2014).
    Keywords: pidgin ; creole ; language origins ; language evolution ; Semantics ; Stratum (linguistics) ; Verb ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    La relación médico-paciente (2021)
    Publicacions i Edicions de la Universitat de Barcelona
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    Publication Date: 2023-12-21
    Description: La relación médico-paciente está sometida a varias presiones. La financiación de la asistencia sanitaria puede determinar tanto la percepción colectiva del acceso a los recursos sociales (prestaciones económicas, centros de atención especializada, ayudas a domicilio, entre otros) como la prescripción de medicamentos y de pruebas complementarias. Además de las prioridades del financiador o de los beneficiarios de los resultados económicos, las campañas publicitarias influyen también en el criterio del paciente, al que la industria farmacéutica halaga convenciéndolo de que posee conocimientos de medicina y de que es un consumidor con el poder de escoger, cuando en realidad decide porque tiene los medios económicos para pagar su elección. En este libro se analizan las razones que empujan a los profesionales de la sanidad hacia una parcialidad interesada, así como las consecuencias éticas que ello tiene sobre el individuo y sobre la eficiencia del sistema sanitario.
    Keywords: R5-920 ; RA1-1270 ; BJ1-1725 ; Relacions metge-pacient ; Medicina ; Dret ; bic Book Industry Communication::M Medicine
    Language: Spanish
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    Global health issues of aflatoxins in food and agriculture: Challenges and opportunities (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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    Marine Compounds and Cancer (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
    Language: English
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    Illokutive Strukturen und Dialoganalyse (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: The aim of this work is to describe dialog structures: dialogue structures that express different attitudes of interlocutors to the conversation and the partner. In addition, however, my hope is to be able to point out a possible way through the description of a dialogical attitude and the corresponding discussion structures, using specific "techniques" so structured and structured conversations that they lead to real understanding and thus to an improvement of the culture of dialogue.
    Description: Das Ziel dieser Arbeit ist es, Dialogstrukturen zu beschreiben: Dialogstrukturen, die Ausdruck unterschiedlicher Haltungen von Gesprächspartnern zum Gespräch und zum Partner sind. Darüber hinaus jedoch ist meine Hoffnung, durch die Beschreibung einer dialogischen Gesprächshaltung und der entsprechenden Gesprächsstrukturen einen möglichen Weg zu weisen, mittels bestimmter "Techniken" Gespräche so strukturieren und gestalten zu können, daß sie zu wirklichem Verständnis und damit zu einer Verbesserung der Dialogkultur fuhren.
    Keywords: dialog structures ; basierend ; begründete ; Dialoganalyse ; dialogisch ; Dialogstrukturen ; Eine ; erweiterte ; Gesprächshaltung ; Illokutive ; Linguistik ; narrativen ; neueren ; Prosa ; Scharpenack ; Slavische Sprachwissenschaft ; Sprechakttheorie ; Strukturen ; Tschechische Republik ; tschechischen ; Unrath ; Untersuchungen ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Epigenetics of B Cells and Antibody Responses (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
    Language: English
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    Der polnische Aphorismus (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Die vorliegende Arbeit behandelt die "Unfrisierten Gedanken" von Stanisław Jerzy Lec. Der Untersuchung der Aphorismen Lec' im dritten Kapitel geht eine theoretische Begründung unseres Aphorismusverständnisses im zweiten Kapitel voraus sowie im ersten Kapitel ein Überblick über die Geschichte des Aphorismus in Polen.
    Keywords: Aphorismus ; Aphoristik ; Gedanken ; Jerzy ; Krupka ; Linguistik ; Literaturwissenschaft ; Philologie ; Platz ; Polen ; polnische ; polnischen ; Sprachwissenschaft ; Stanisław ; Unfrisierten ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    The evolution of grounded spatial language (2021)
    Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: This book presents groundbreaking robotic experiments on how and why spatial language evolves. It provides detailed explanations of the origins of spatial conceptualization strategies, spatial categories, landmark systems and spatial grammar by tracing the interplay of environmental conditions, communicative and cognitive pressures. The experiments discussed in this book go far beyond previous approaches in grounded language evolution. For the first time, agents can evolve not only particular lexical systems but also evolve complex conceptualization strategies underlying the emergence of category systems and compositional semantics. Moreover, many issues in cognitive science, ranging from perception and conceptualization to language processing, had to be dealt with to instantiate these experiments, so that this book contributes not only to the study of language evolution but to the investigation of the cognitive bases of spatial language as well.
    Keywords: robotic experiments ; spatial language ; spatial grammar ; Adjective ; Adverb ; Anatomical terms of location ; Chinese grammar ; Evolution ; Frame of reference ; Parsing ; Preposition and postposition ; Semantics ; Syntax ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::U Computing and Information Technology
    Language: English
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    Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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    Morpho-Syntactic Expansions in Translation from English into Slovenian as a Prototypical Response to the Complexity of the Original (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉This work deals with the morpho-syntactic expansions which occur in translation from English into Slovenian, proceeding from the assumption that such expansions are the most common, "prototypical" response of the translator when faced by an original containing grammatically complex structures.〈/P〉
    Keywords: Complexity ; Control group ; English ; Expansions ; from ; into ; Milena ; Milojević ; Morpho ; Morpho-syntactic expansions ; non-systemic expansion ; Original ; Prototypical ; Response ; Sheppard ; Slovenian ; Syntactic ; Translation ; translation studiesw ; unit of translation ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    A grammar of Sanzhi Dargwa (Volume 2) (2021)
    Language Science Press | Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: Sanzhi Dargwa belongs to the Dargwa (Dargi) languages (ISO dar; Glottocode sanz1248) which form a subgroup of the East Caucasian (Nakh-Dagestanian) language family. Sanzhi Dargwa is spoken by approximately 250 speakers and is severely endangered. This book is the first comprehensive descriptive grammar of Sanzhi, written from a typological perspective. It treats all major levels of grammar (phonology, morphology, syntax) and also information structure. Sanzhi Dargwa is structurally similar to other East Caucasian languages, in particular Dargwa languages. It has a relatively large consonant inventory including pharyngeal and ejective consonants. Sanzhi morphology is concatenative and mainly suffixing. The language exhibits a mixture of dependent-marking in the form of a rich case inventory and head-marking in the form of verbal agreement. Nouns are divided into three genders. Verbal inflection conflates tense/aspect/mood/evidentiality in a rich array of synthetic and analytic verb forms as well as participles, converbs, a masdar (verbal noun), and infinitive and some other forms used in analytic tenses and subordinate clauses. Salient traits of the grammar are two independently operating agreement systems: gender/number agreement and person agreement. Within the nominal domain, modifiers agree with the head nominal in gender/number. Agreement within the clausal domain is mainly controlled by the argument in the absolutive case. Person agreement operates only at the clausal level and according to the person hierarchy 1, 2 〉 3. Sanzhi has ergative alignment in the form of gender/number agreement and ergative case marking. The most frequent word order at the clause level is SOV, though all other logically possible word orders are also attested. In subordinate clauses, word order is almost exclusively head-final.
    Keywords: Language Arts & Disciplines ; Linguistics ; General ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Studien zum Dual (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: The aim of this study is to describe and analyze the dual system of the New Testament of Miklavuš Jakubica (1548), because of the Du. a variety of individual studies exist, such. For example, to discuss the numerus category in Slavic in general, general representations of Sorbian with descriptions of dual paradigms, descriptions of individual inflectional paradigms of Ns, their peculiarities and genesis (...). The author sets himself the goal, after some introductory remarks on the translation of the NT by Miklawuš Jakubica in the second chapter, to discuss theoretical foundations of the morphological category, essentially referring to the number in general, the origin of the Du. and its different forms, like natural or free, you. with two and both and anaphoric you. will be received. The investigation is done both from a synchronous and a diachronic point of view, since paradigmatic comparisons with older ns. Grammars as well as with the contemporary language to be drawn.
    Description: Die vorliegende Untersuchung verfolgt das Ziel, das Dualsystem des Neuen Testaments des Miklawuš Jakubica ( 1548) zu beschreiben und zu analysieren, da über den Du. eine Vielzahl von Einzeluntersuchungen existieren, wie z. B. zur Erörterung der Numeruskategorie im Slavischen im allgemeinen, allgemeine Darstellungen zum Sorbischen mit Beschreibungen der Dualparadigmen, Beschreibungen einzelner Flexionsparadigmen des Ns., deren Besonderheiten und Genese (...). Der Verfasser stellt sich das Ziel, nach einigen einleitenden Bemerkungen zur Übersetzung des NT von Miklawuš Jakubica im 2. Kapitel theoretische Grundlagen zur morphologischen Kategorie zu erörtern, wobei im wesentlichen auf den Numerus im allgemeinen, den Ursprung des Du. und dessen verschiedene Formen, wie natürlicher oder freier, Du. mit zwei und beide und anaphorischer Du. eingegangen wird. Die Untersuchung erfolgt sowohl aus synchroner als auch aus diachroner Sicht, da paradigmatische Vergleiche mit älteren ns. Grammatiken als auch mit der Gegenwartssprache gezogen werden sollen.
    Keywords: 1548 ; Analyse ; Darstellung ; Dual ; Genese ; Jakubica ; Miklawuš ; Neuen ; niedersorbischen ; Numeruskategorie ; paradigmatische Vergleiche ; Slavische Sprachwissenschaft ; sprachwissenschaftliche ; Studien ; Testament ; Theologie ; Unger ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Saúde, trabalho e formação profissional (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Reúne textos de especialistas das áreas de Saúde e de Educação com longa, competente e comprometida atuação na luta por mudanças sociais, preocupados com um (con)viver humano mais solidário. A obra mostra ser possível a constituição de serviços de saúde com profissionais sensíveis e preparados para atuar em tempos de novas exigências técnicas e de capacitação profissional. Por instigar a (re)pensar o aperfeiçoamento técnico e ético do trabalho, com idéias e propostas originais e atuais, trata-se, certamente, de contribuição de relevância para aqueles que, direta ou indiretamente, encontram-se engajados na causa do Sistema Único de Saúde.
    Keywords: R5-920 ; Pessoal técnico de saúde-educação ; Ocupação em saúde ; educação profissional ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Immune responses to AAV vectors, from bench to bedside (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
    Language: English
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    Malyj dialektologičeskij atlas balkanskich jazykov. Serija grammatičeskaja (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Der hier vorliegende Kartenband behandelt die grammatischen Kategorien des Substantivs in den Sprachen Südosteuropas, wobei die Sprachdaten aus 12 südosteuropäischen Ortspunkten auf 127 Karten präsentiert werden. Als Grundlage dient das Sprachmaterial, das in internationaler Zusammenarbeit im Rahmen des Forschungsprojektes "Malyj dialektologičeskij atlas balkanskich jazykov/Kleiner Balkansprachatlas" erhoben und bearbeitet wurde
    Keywords: atlas ; balkanskich ; dialektologičeskij ; grammatičeskaja ; imeni ; jazykov ; Kategorii ; Kleiner Balkansprackatlas ; Linguistik ; Malyj ; nogo ; Serija ; slavische Sprachwissenschaft ; Sobolev ; Sprachkarten ; Südosteuropäische Sprachen ; suščestvitel ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Russian
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    Chapter 4 Preschool education (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-03-24
    Description: "The Routledge Handbook of Translation and Education will present the state of the art of the place and role of translation in educational contexts worldwide. It lays a sound foundation for the future interdisciplinary cooperation between Translation Studies and Educational Linguistics. By adopting a transdisciplinary perspective, the handbook will bring together the various fields of scholarly enquiry and practice that make a valuable contribution to enlarging the notion of translation and diversifying its uses in education. Each contribution provides an overview of the historical background to a given educational setting. Focusing on current research approaches and empirical findings, this volume outlines the development of pedagogical approaches, methods, assessment and curriculum design. The handbook also examines examples of pedagogies that integrate translation in the curriculum, the teaching method’s approach, design and procedure as well as assessment. Based on a multilingual and applied-oriented approach, the handbook is essential reading for postgraduate students, researchers and advanced undergraduate students of Translation Studies, and educationalists and educators in the 21st century post-global era."
    Keywords: Sara Laviosa ; Maria González-Davies ; Translation Studies ; Translation ; Applied Linguistics ; Communication Studies ; Multilingualism ; Educational Theory ; Educational Linguistics ; Education ; Bilingualism ; Intercultural ; Interpreting Studies ; Language Learning ; Language Education ; Deaf Education ; Sign Language ; Teacher Training ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    How mobile robots can self-organise a vocabulary (2021)
    Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: One of the hardest problems in science is the symbol grounding problem, a question that has intrigued philosophers and linguists for more than a century. With the rise of artificial intelligence, the question has become very actual, especially within the field of robotics. The problem is that an agent, be it a robot or a human, perceives the world in analogue signals. Yet humans have the ability to categorise the world in symbols that they, for instance, may use for language. This book presents a series of experiments in which two robots try to solve the symbol grounding problem. The experiments are based on the language game paradigm, and involve real mobile robots that are able to develop a grounded lexicon about the objects that they can detect in their world. Crucially, neither the lexicon nor the ontology of the robots has been preprogrammed, so the experiments demonstrate how a population of embodied language users can develop their own vocabularies from scratch.
    Keywords: language in robots ; artificial intelligence ; Feature extraction ; Feature vector ; Joint attention ; Lexicon ; Reference ; Symbol grounding problem ; Talking Heads ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::U Computing and Information Technology
    Language: English
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    Chapter B1 Linguistic Features of Legal Language (2021)
    Taylor & Francis | A Global History of Ideas in the Language of Law | Language and Law | Routledge
    Details
    Publication Date: 2024-03-24
    Description: Language plays an essential role both in creating law and in governing its implementation. Providing an accessible and comprehensive introduction to this subject, Language and Law:describes the different registers and genres that make up spoken and written legal language and how they develop over time; analyses real-life examples drawn from court cases from different parts of the world, illustrating the varieties of English used in the courtroom by speakers occupying different roles; addresses the challenges presented to our notions of law and regulation by online communication; discusses the complex role of translation in bilingual and multilingual jurisdictions, including Hong Kong and Canada; and provides readings from key scholars in the discipline, including Lawrence Solan, Peter Goodrich, Marianne Constable, David Mellinkoff, and Chris Heffer. With a wide range of activities throughout, this accessible textbook is essential reading for anyone studying language and law or forensic linguistics.
    Keywords: English for law ; English for specific purposes law ; forensic linguistics ; language and the law ; legal English ; legal genres ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::L Law::LA Jurisprudence and general issues ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAR Legal aspects of criminology ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAS Legal skills and practice
    Language: English
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    CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Communicating Medicine (2021)
    Ledizioni
    Details
    Publication Date: 2023-12-21
    Description: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Keywords: R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
    Language: English
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    Três ensaios de bioética (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Leitores interessados no desenvolvimento teórico da bioética e, ao mesmo tempo, em sua aplicação na solução de conflitos morais certamente encontrarão neste livro materiais de grande valor. Cada capítulo coloca a bioética em um contexto diferente: na clínica, na genômica e na biossegurança. No primeiro ensaio, discutem-se as possibilidades dessa ‘caixa de ferramentas’ chamada bioética para compreender e tentar resolver conflitos de interesses e valores no âmbito das relações entre profissionais e usuários dos serviços de saúde. No segundo, o autor aplica as ferramentas da bioética ao caso dos conflitos morais que envolvem a genômica, contemplando argumentos favoráveis e contrários às práticas da engenharia genética e contribuindo para o raciocínio crítico e sem preconceitos sobre o tema. Por fim, o terceiro capítulo trata da interface entre a bioética e a biossegurança, que têm preocupações comuns, como a questão dos riscos, mas abordagens distintas – enquanto a bioética se ocupa dos valores morais, a biossegurança lança mão de medidas técnicas, administrativas e legais.
    Keywords: R5-920 ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Chomskyan (R)evolutions (2021)
    John Benjamins Publishing Company | John Benjamins Publishing Company
    Details
    Publication Date: 2024-03-24
    Description: It is not unusual for contemporary linguists to claim that “Modern Linguistics began in 1957” (with the publication of Noam Chomsky’s Syntactic Structures). Some of the essays in Chomskyan (R)evolutions examine the sources, the nature and the extent of the theoretical changes Chomsky introduced in the 1950s. Other contributions explore the key concepts and disciplinary alliances that have evolved considerably over the past sixty years, such as the meanings given for “Universal Grammar”, the relationship of Chomskyan linguistics to other disciplines (Cognitive Science, Psychology, Evolutionary Biology), and the interactions between mainstream Chomskyan linguistics and other linguistic theories active in the late 20th century: Functionalism, Generative Semantics and Relational Grammar. The broad understanding of the recent history of linguistics points the way towards new directions and methods that linguistics can pursue in the future.
    Keywords: Language Arts & Disciplines ; Linguistics ; General ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Lipid Signaling in T Cell Development and Function (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
    Language: English
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    Foundations of Paleoparasitology (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Unprecedented initiative in the world, the book compiles the available knowledge on the subject and presents the state-of-the-art in paleoparasitology – term coined about 30 years ago by Brazilian Fiocruz researcher Luiz Fernando Ferreira, pioneer in this science which is concerned with the study of parasites in the past. Multidisciplinary by essence, paleoparasitology gathers contributions from social scientists, biologists, historians, archaeologists, pharmacists, doctors and many other professionals, either in biomedical or humanities fields. With varied applications such as in evolutionary or migration studies, their results often depend on the association between laboratory findings and cultural remains. The book is divided into four parts - Parasites, Hosts, and Human Environment; Parasites Remains Preserved in Various Materials and Techniques in Microscopy and Molecular Diagnostics; Parasite Findings in Archeological Remains: a paleographic view; and Special Studies and Perspectives. Signed by authors from various countries such as Argentina, USA, Germany and France, the book has chapters devoted to the discoveries of paleoparasitology on all continents.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: English
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    Tonal placement in Tashlhiyt (2021)
    Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: In most languages, words contain vowels, elements of high intensity with rich harmonic structure, enabling the perceptual retrieval of pitch. By contrast, in Tashlhiyt, a Berber language, words can be composed entirely of voiceless segments. When an utterance consists of such words, the phonetic opportunity for the execution of intonational pitch movements is exceptionally limited. This book explores in a series of production and perception experiments how these typologically rare phonotactic patterns interact with intonational aspects of linguistic structure. It turns out that Tashlhiyt allows for a tremendously flexible placement of tonal events. Observed intonational structures can be conceived of as different solutions to a functional dilemma: The requirement to realise meaningful pitch movements in certain positions and the extent to which segments lend themselves to a clear manifestation of these pitch movements.
    Keywords: berber languages ; pitch movements ; vowels ; voice ; tonal events ; Intonation (linguistics) ; Phonetics ; Phonology ; Prosody (linguistics) ; Schwa ; Sonorant ; Stress (linguistics) ; Syllable ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Biomedical Insights that Inform the Diagnosis of ME/CFS (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Keywords: R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
    Language: English
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    Accessible Communication (2021)
    Frank & Timme
    Details
    Publication Date: 2024-03-29
    Description: Easy-to-Understand (E2U) text practices enable and facilitate accessible communication. E2U refers both to Plain and to Easy Language. These two powerful methods of language and content comprehension enhancement are illustrated through several examples in English, starting from the seminal role of the Anglophone world in promoting plain and lucid style. Originally implemented in written texts, today the employment of these simplified language varieties should infiltrate new communication services that are more complex and multifaceted. Thanks to the EASIT project, the integration of E2U strategies into a selection of audiovisual services is being successfully researched. After advancing simplification proposals in the area of subtitling and audio description, Elisa Perego reports on the results of a cross-country survey conducted during the initial stages of the EASIT project: She pinpoints the background, activity, and training experience of those who currently work in the sector of E2U in Europe, and identifies the skills and the competences of, as well as a training path and materials for, future hybrid professionals.
    Keywords: Audio description; audiovisual translation; blind; EASIT; easy language; inclusion; accessibility; plain language; plain english; visually impaired; voice-over ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::C Language::CF linguistics ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    The Schistosomiasis Vaccine - It Is Time to Stand Up (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis.
    Keywords: R5-920 ; RC581-607 ; Schistosomiasis ; Schistosoma mansoni ; Schistosoma haematobium ; Type 2 cytokines ; Vaccine ; Immune responses ; Schistosoma japonicum ; Vaccine candidates ; bic Book Industry Communication::M Medicine
    Language: English
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    Die sowjetische Geschichtswissenschaft 1953 bis 1991 (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: In der Reihe Marburger Abhandlungen zur Geschichte und Kultur Osteuropas erscheinen Monographien und Sammelbände aus dem Bereich der Slawistik. Neben literatur- und geschichtswissenschaftlichen Studien, die den thematischen Fokus der Reihe darstellen, finden auch Studien aus der Sprachwissenschaft Berücksichtigung.
    Keywords: 1953 ; 1991 ; Geschichte ; Geschichtswissenschaft ; Hösler ; Linguistik ; Methodologie ; Organisationsgeschichte ; Osteuropa ; Slavische Sprachwissenschaft ; Slawistik ; sowjetische ; Studien ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Less and Non-invasive Hemodynamic Monitoring Techniques (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: In the perioperative setting and in intensive care medicine, early and effective hemodynamic management including fluid therapy and administration of vasoactive drugs to maintain vital organ perfusion and oxygen delivery is mandatory. Understanding the different approaches in the management of critically ill patients during the resuscitation and further management is essential to initiate adequate context- and time-specific interventions. Optimization of hemodynamic variables to achieve a balance between organ oxygen delivery and consumption is a cornerstone. In general, cardiac output (i.e., the blood flow) is considered a major determinant of oxygen supply and thus its monitoring is regarded helpful. However, indicators of oxygen requirements are equally necessary to assess adequacy of oxygen supply. Currently, more and more less or even totally non-invasive monitoring systems have been developed and clinically introduced, but they require validation in particular clinical settings. Cardiac output monitors and surrogates of organ oxygenation only enable to adequately guide management, as patient’s outcome is determined by acquisition and interpretation of accurate measurements, and finally, suitable management decisions. This Research Topic focuses on the currently available techniques, especially the less and non-invasive ones, in the field of hemodynamic monitoring in the perioperative setting and in critically ill patients while summarizing their advantages and limitations.
    Keywords: R5-920 ; Blood Pressure ; Cardiovascular dynamics ; goal-directed therapy ; intensive care medicine ; Cardiac Output ; Anesthesiology ; bic Book Industry Communication::M Medicine
    Language: English
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    Russische Grammatik (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Lomonosovs "Rossijskaja Grammatika" ist in ihrer Bedeutung für die Entwicklung der Theorie der russischen Grammatik im 18. Jh. unbestritten. Darauf weisen nicht zuletzt die wiederholten Ausgaben seit dem Jahre 1757 (Fertigstellung 1755) hin. Neben den russischsprachigen Ausgaben hat die deutsche Übersetzung durch den Archivar Johann Lorenz Stavenhagen insofern eine besondere Bedeutung, als Lomonosov für diese eine nicht unwesentliche Anzahl von Veränderungen gegenüber dem russischen Original vorgenommen hat. Aus d. Russ. übersetzt
    Keywords: 1764 ; Ausgabe ; Grammatik ; Johann ; Johann Lorenz Stravenhagen ; Lomonosov ; Lomonosov ; Lorenz ; Nachdruck ; Petersburg ; Russische ; russische Grammatik ; Russischen ; Slavische Sprachwissenschaft ; Stavenhagen ; Theorie der russischen Grammatik ; übersetzt ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Medicamentos no Brasil : inovação e acesso (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Uma das particularidades da área da saúde é pertencer tanto à esfera social quanto à industrial, característica que representa oportunidades e grandes desafios. O livro Medicamentos no Brasil: inovação e acesso tem o objetivo de fomentar o desenvolvimento tecnológico e fortalecer a produção nacional, além de garantir que o conhecimento desses avanços beneficie a população brasileira. Como afirma o ministro da Saúde, José Gomes Temporão, no prefácio: “...inovação não pode estar desligada da idéia de acesso”. Reunindo os pontos de vista da academia, governo e setor produtivo público e privado, com abordagens que privilegiam o contexto nacional e refletem sobre a posição brasileira no cenário internacional, a obra apresenta um diagnóstico da área de medicamentos no país, avalia seus problemas e potencialidades e faz recomendações concretas para superação dos obstáculos e aproveitamento das oportunidades. Cabe destacar que é o segundo volume de uma série sobre pesquisa, desenvolvimento e inovação nos segmentos industriais da saúde, do Projeto Inovação em Saúde (presidência/Fiocruz), cujo primeiro livro é Vacinas, Soros e Imunizações no Brasil.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Bulletin der deutschen Slavistik. Jahrgang 20, 2014 (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Das Bulletin der deutschen Slavistik wird herausgegeben im Auftrag des Slavistenverbandes von Sebastian Kempgen und Ludger Udolph sowie dem Redaktionskollegium Hermann Fegert, Norbert Franz, Gerhard Giesemann, Ulrike Jekutsch und Monika Wingender. Es bietet alljährlich aktuelle Informationen zu den Slavistik-Standorten in Deutschland, zu slavistischer Forschung und Veröffentlichungen, zu Tagungen, Kooperationen, Studiengängen und einschlägigen Entwicklungen im Fach. Es würdigt Fachvertreter, während sich Nachwuchswissenschaftler/innen mit einem Kurzporträt selbst vorstellen. Das Bulletin ist auch Forum für kritische Auseinandersetzungen in und mit dem Fach und beschränkt sich dabei nicht auf nationale Grenzen.
    Keywords: Bulletin ; deutschen ; Jahrgang ; Kempgen ; Linguistik ; Literaturwissenschaft ; Ludger ; Philologie ; Russland ; Sebastian ; Slavistik ; Soziologie ; Sprachwissenschaft ; Udolph ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Dependencies in language: On the causal ontology of linguistic systems (2021)
    Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: Dependency is a fundamental concept in the analysis of linguistic systems. The many if-then statements offered in typology and grammar-writing imply a causally real notion of dependency that is central to the claim being made—usually with reference to widely varying timescales and types of processes. But despite the importance of the concept of dependency in our work, its nature is seldom defined or made explicit. This book brings together experts on language, representing descriptive linguistics, language typology, functional/cognitive linguistics, cognitive science, research on gesture and other semiotic systems, developmental psychology, psycholinguistics, and linguistic anthropology to address the following question: What kinds of dependencies exist among language-related systems, and how do we define and explain them in natural, causal terms?
    Keywords: language-related systems ; meta-linguistics ; dependency ; Phonology ; Prosody (linguistics) ; Syntax ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Blood-Derived Products for Tissue Repair/Regeneration (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
    Keywords: R5-920 ; RM1-950 ; n/a ; biomaterial ; redifferentiation ; regenerative medicine ; skeletal muscle regeneration ; furcation defects ; Platelet-Rich Plasma (PRP) ; PRP ; fracture ; fibrin sealant ; periodontal surgery ; bone regeneration ; serum derived from plasma rich in growth factors (s-PRGF) ; cartilage repair ; myofibroblasts ; autologous platelet concentrates ; burns ; satellite cells ; articular cartilage ; stem cell niche ; wound healing ; quantification ; growth factors ; biologics ; platelet rich plasma ; meniscus ; adipose tissue ; Carprofen ; platelet-rich fibrin ; platelets ; hyperacute serum ; bone defects ; serum eye drops ; corneal epithelial defect ; fibrosis ; dog ; myoblasts ; differentiation ; chronic meniscal lesion ; horizontal meniscal tear ; PRGF ; collagen hydrogels ; periodontal defects ; bone grafting material ; composition ; cell therapy ; bone healing ; tissue healing ; trephination ; plasma rich plasma (PRP) ; bone repair ; plasma rich in growth factors ; knee arthrosis ; meniscus tear ; cornea regeneration ; wrist osteoarthritis ; periosteal sheet ; Platelet-Poor Plasma (PPP) ; platelet-rich plasma ; microfat ; bone grafting ; hyaluronic acid (NaHA) ; periodontal regeneration ; meniscus repair ; photobiomodulation therapy ; growth ; myogenesis ; blood derived products ; low-level laser therapy ; bic Book Industry Communication::M Medicine
    Language: English
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    Beiträge zur deutschen Grammatik (2021)
    Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: This volume contains the complete collection of published and unpublished work on German grammar by Tilman N. Höhle. It consists of two parts. The first part is Topologische Felder, a book-length manuscript that was written in 1983 but was never finished nor published. It is a careful examination of the topological properties of German sentences, including a discussion of typological assumptions. The second part assembles all other published and unpublished papers by Höhle on German grammar. All of these papers were highly influential in German linguistics, in theoretical linguistics in general, and in a specific variant of theoretical linguistics, Head-Driven Phrase Structure Grammar. Topics covered are clause structure, constituent order, coordination, (verum) focus, word structure, the relationship between relative pronouns and verbs in V2, extraction, and the foundations of a theory of phonology in constraint-based grammar.
    Keywords: Linguistics ; Derivation (Linguistik) ; Finite Verbform ; Haushund ; Höhle ; Subjekt (Grammatik) ; Verb ; Wortstellung ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Ventricular Mechanics in Congenital Heart Disease (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Looking at "Horse in Motion", the iconic photograph by E. Muybridge, it is almost possible to hear the horse galloping. The pounding sound of the hoofs hitting the ground -like a drum- can also echo the rythmic beating of the human heart. That sound, that visceral rhythm, reminds us of the link between motion and performance: the perfectly executed stride of the horse, the incredible coordination of multiscale phenomena behind a heart beat. Furthermore, the decomposed sequence in Muybridge's photograph has become a well-known example of breaking motion into its components over time, and as such is reminiscent of those images that are routinely acquired in clinical practice, where the heart appears dilating and shirnking in a sequence of snapshots. The investigation of this motion and its subtleties is essential for refining our understanding of cardiac function, and the appreciation of how and when this motion is no longer perfectly executed can lead us to understand functional impairments and provide insight into the unfolding of pathology. In the presence of congenital heart disease (CHD), cardiac mechanics are altered: from single ventricle physiology to conduction abnormalities to different cardiomyopathies, it is important to both capture and interpret biomechanical changes that occur in the presence of a congenital defect. This special issue in Frontiers in Pediatrics, now an e-book, focuses on 'Ventricular mechanics in congenital heart disease' and looks at current knowledge of phenomena such as systolic/diastolic dysfuction and current methods (chiefly in cardiovascular magnetic resonance imaging and echocardiography) to evaluate cardiac function in the presence of CHD, and then presents a series of original studies that employ both medical imaging and computational modelling techniques to study specific CHD scenarios.
    Keywords: R5-920 ; RJ1-570 ; cardiovascular magnetic resonance imaging ; ventricular mechanics ; Congenital Heart Diseases ; hypoplastic left heart syndrome ; diastolic function ; computational modelling ; systolic function ; haemodynamics ; bic Book Industry Communication::M Medicine
    Language: English
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    Linguistische Beitraege zur Slavistik aus Deutschland, Oesterreich und der Schweiz (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: This volume documents the Third Meeting of the Boys' Slaves, which took place from 30 September to 2 October 1994 in Hamburg. The meetings are understood to be workshops with a certain workshop character, the participants consciously recruit from the circle of junior slavists who are not yet habilitated and / or in a position of life. In keeping with the workshop character, contributions were also presented at the meeting which, as components of more comprehensive work or as interim results of larger projects, were not intended for publication in the given context. These are Sylke Eichler (Leipzig), Dorothee Fehrmann (Leipzig), Robert Hammel (Göttingen), Uwe Junghanns (Berlin) and Jana Schulze (Leipzig / Bautzen).
    Description: Im vorliegenden Band wird das Dritte Treffen der Jungslavistlnnen dokumentiert, das vom 30. September bis 2. Oktober 1994 in Hamburg stattfand. Die Treffen verstehen sich als Arbeitstreffen mit einem gewissen Workshop-Charakter, die Teilnehmer rekrutieren sich bewußt aus jenem Kreis von Nachwuchs-Slavistlnnen, die noch nicht habilitiert und/oder in einer Lebensstellung befindlich sind. Dem Workshop-Charakter angemessen wurden auf dem Treffen auch Beiträge vorgestellt, die als Bestandteile umfassenderer Arbeiten bzw. als Zwischenergebnisse größerer Vorhaben nicht zur Veröffentlichung im gegebenen Zusammenhang gedacht waren. Bei diesen handelt es sich um Sylke Eichler (Leipzig), Dorothee Fehrmann (Leipzig), Robert Hammel (Göttingen), Uwe Junghanns (Berlin) und Jana Schulze (Leipzig/Bautzen).
    Keywords: 1994 ; Arbeitstreffen ; Beiträge ; Deutschland ; Dippong ; Hamburg ; JungslavistInnen ; Linguistik ; Linguistische ; Marszk ; Mitwirkung ; Österreich ; Rauchenecker ; Schweiz ; Slavische Sprachwissenschaft ; Slavistik ; Teilnehmer ; Treffen ; Unter ; Workshop ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Da compaixão à solidariedade : uma genealogia da assistência médica (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: A autora apresenta uma análise que vai da lógica da compaixão à lógica utilitarista, modalidades diferenciadas de intervenção sobre a saúde das pessoas e coletividades no século XIX e que, apesar de aparentemente antagônicas, estão mais próximas do que se possa imaginar. Analisa as motivações éticas a partir das quais se legitimaram diversas modalidades de assistência médica aos necessitados. Examina, também, a história de certas práticas e estratégias - a transformação do hospital em espaço médico, o papel da caridade e da filantropia e o nascimento da família moderna como agente de controle médico das populações. Constitui-se, assim, importante reflexão sobre os limites das duas estratégias das políticas assistenciais
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Kontrastiva studier i nederländska och svenska (2021)
    Stockholm University Press
    Details
    Publication Date: 2024-03-23
    Description: This book deals with two research fields and brings them together: contrastive linguistics and third language acquisition. The book describes the following linguistic structures in Dutch and Swedish from a contrastive perspective: spatial adverbs, copula, impersonal passives, impersonal constructions and finally the posture verbs stand, zit and lie. Dutch and Swedish are usually acquired as a third language and not as a second language, which implies that learners already comprehend various other languages. When learning a language these multilingual learners have developed certain strategies which draw on their competence in earlier studied languages. In the process of learning a third language, metalinguistic and cross-linguistic awareness play an important role. Comparing linguistic structures in two closely related languages as Dutch and Swedish can enhance cross-linguistic awareness and therefore be used as a didactic tool.
    Keywords: Dutch ; Swedish ; Contrastive linguistics ; Third language acquisition ; Cross-linguistic awareness ; thema EDItEUR::2 Language qualifiers::2A Indo-European languages ; thema EDItEUR::C Language and Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFF Historical and comparative linguistics ; thema EDItEUR::C Language and Linguistics::CJ Language teaching and learning ; thema EDItEUR::N History and Archaeology::NH History
    Language: Swedish
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    Die Handwerkerbezeichnungen im Alttschechischen (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Diese Arbeit soll als ein Beitrag zur Wortbildung im Alttschechischen verstanden werden. Die Untersuchung der Benennungsvorgänge und die Feststellung der wortbildenden Mittel der in dieser Arbeit untersuchten Termini stützt sich in erster Linie auf Material, das von Autor zum ersten Mal aus den Quellen erschlossen wurde.
    Keywords: Alttschechischen ; Handwerkerbezeichnungen ; Linguistik ; Malingoudis ; Philologie ; Sprachtheorie ; Sprachwissenschaft ; Tschechische Republik ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Thyroid hormone in brain and brain cells (2021)
    Frontiers Media SA
    Details
    Publication Date: 2022-01-31
    Description: Thyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormone, have not been a priority within the field. This is changing mainly for two reasons. First, new genetic diseases have been discovered, altering thyroid hormone signaling in brain (THRA, MCT8, SBP2), with neurodevelopmental consequences which are currently incurable. Second, there is a growing concern that exposition of the general population to environmental chemicals able to interfere with thyroid hormone signaling compromises children neurodevelopment or induces central disorders in adults. Finally thyroid hormone is acting directly on gene transcription, by binding nuclear receptors, and therefore is an interesting entry point to identify genetic programs controlling brain development and function. Reaching a broad understanding of the multiple processes involving thyroid hormone in brain is a tremendous task which will necessitate a multidisciplinary approach: animal genetics, molecular biology, brain imaging, developmental biology, genomics, etc... This topic will be the occasion to combine recent contributions in the field and to identify priorities for future investigations. Due to devastating consequences of congenital hypothyroidism, the neurodevelopmental consequences of altered thyroid hormone signaling have been extensively studied over the years. The discovery of new genetic diseases, the concern about the possible neurotoxicity of environmental thyroid hormone disruptors, recently renewed the interest for an important research field. This Ebook gathers reviews and original data from experts in various disciplines. It provides a broad view of ongoing research and outlines key issues for future investigation.
    Keywords: RC648-665 ; R5-920 ; thyroid hormone ; neurodevelopment ; transporter ; nuclear receptor ; brain ; deiodinase
    Language: English
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    Die Entwicklung analytischer Konstruktionen in der russischen Fachsprache der Mathematik seit dem 18. Jahrhundert (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉Wenn es um Tendenzen in der neueren russischen Sprache geht, fällt recht oft das Wort Analytismus. Eine Entwicklung hin zum Analytismus wird oft als eine der deutlichsten Tendenzen in der russischen Gegenwartssprache genannt. Die Analyse der morpho-syntaktischen und lexiko-semantischen Struktur sowie der funktionalen Charakteristika analytischer K onstruktionen soll Hinweise auf Gründe für eine Tendenz zum Analytismus geben. Hauptziel der Untersuchung ist es festzustellen, wie deutlich und bestimmend die Tendenz zum Analytismus für die russische Fachsprache der Mathematik in ihrer Entwicklung seit dem 18. Jahrhundert, das heißt seit dem ersten in Rußland gedruckten Mathematikbuch, der Arithmetik Magnickijs aus dem Jahre 1703, gewesen ist. 〈/P〉
    Keywords: analytischer ; Analytismus ; Entwicklung ; Fachsprache ; Jahrhundert ; Konstruktionen ; Linguistik ; Mathematik ; Reitz ; russischen ; Russland ; seit ; Slavische Sprachwissenschaft ; Sprachtheorie ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Natural Antibodies in Health and Disease (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition, NAbs play a role in preventing the expansion of specific auto-reactive clones, thereby behaving as regulatory elements in acute or chronic inflammation. To maintain the non-pathogenic balance between the dual pathogen/self-antigen cross-reactivities of NAbs, a strict regulation in NAb secretion and function is necessary to avoid autoimmune disease. Actually, some of the NAbs related auto-reactivities, such as anti-DNA and anti-MOG, have been associated with autoimmunity. Furthermore, NAbs have been shown to bind to ‘neo-self’ carbohydrate antigens on glycolipids and glycoproteins found on malignant but not normal cells, which suggests NAbs may take part in tumor immunosurveillance. Many aspects regarding NAbs have yet to be studied in more detail: the reactivity and function of NAbs in health and disease, the behavior of the NAb repertoire with increasing age, the regulation of natural antibody production and auto-reactivity, the ways to specifically activate NAbs producing cells with desired specificities, the characteristics of human NAbs, among others. This special topics eBook consists of a number of articles exploring the cells that produce NAbs as well as the characteristics, function, specificity, and/or the role of natural antibodies in health and disease.
    Keywords: R5-920 ; RC581-607 ; innate immunity ; immunoglobulin ; Antibodies ; B cells ; IgM ; natural antibodies ; B-1 cells ; bic Book Industry Communication::M Medicine
    Language: English
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    Homeostasis and Allostasis of Thyroid Function (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values.〈/p〉〈p〉A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. 〈/p〉〈p〉Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome.〈/p〉〈p〉A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment.〈/p〉〈p〉Considerable progress has been made in this respect in the following key areas:〈/p〉〈p〉• the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure,〈/p〉〈p〉• the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects,〈/p〉〈p〉• the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression,〈/p〉〈p〉• the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates,〈/p〉〈p〉• the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load.〈/p〉〈p〉This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
    Keywords: R5-920 ; RC648-665 ; relational stability ; Thyronamines ; TSH-T3 Shunt ; thyroid allostasis ; precision medicine ; Stratified Medicine ; 3-T1AM ; Hypothyroidism ; Thyroid homeostasis ; Hysteresis ; bic Book Industry Communication::M Medicine
    Language: English
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    New treatment perspectives in autism spectrum disorders (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core domains of social and communication dysfunction. The pathogenesis paradigm shift of ASD towards synaptic abnormalities moved the research to pathway to disease that involve multiple systems and that are becoming the forefront of ASD treatment and are pointing toward the development of new targeted treatments. Some new therapeutics have been tested and others are being studied. In this context single gene disorders frequently associated with ASD such as Rett Syndrome, Fragile X and Tuberous Sclerosis have been of significant aid as neurobiology of these disorders is more clear and has a potential to shed light on the altered signaling in ASD. However much research is needed to further understand the basic mechanisms of disease and the relationship to idiopathic ASD. Clinical trials in children are underway with agents directed to core symptoms and to the associated disorders in the search of new therapeutics and progress are expected with possible new option for therapeutics in ASD in the upcoming future. Children and Adolescents with ASD and their families can provide important information about their experience with new treatments and this should be a priority for future research. In addition, research performed on genetic mouse models of ASD will keep on providing useful information on the molecular pathways disrupted in the disease, thus contributing to identify novel drug targets.
    Keywords: R5-920 ; RJ1-570 ; Clinical Trial ; mouse model ; neurodevelopmental disorder ; Genetics ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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    Wortbildung und Kategorisierung am Beispiel der desubstantivischen Wortbildung des Russischen (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: This study is dedicated to the analysis and categorization of derived words of Russian; Their concern can be summarized in two questions: a) what part does the word formation meaning have in the lexical meaning of the derived word? b) What are the semantic building blocks of the word formation system of a language (its word formation categories)?
    Description: Diese Untersuchung ist der Analyse und Kategorisierung abgeleiteter Wörter des Russischen gewidmet; ihr Anliegen kann in zwei Fragen zusammengefaßt werden: a) welchen Anteil hat die Wortbildungsbedeutung an der lexikalischen Bedeutung des abgeleiteten Wortes? b) welches sind die semantischen Bausteine des Wortbildungssystems einer Sprache (ihre Wortbildungskategorien)?
    Keywords: Beispiel ; desubstantivis ; desubstantivischen ; Kakridis ; Kategorisierung ; Konkrete Substantive ; Metaphorische und metonymische Ableitungsbeziehungen ; Russischen ; Wortbildung ; Wortbildung und Polysemie ; Wortbildungskategorien und Komponentenanalyse ; Wortbildungsparadigmen ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Mieć, "to have" in Modern Polish (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: In der Reihe Slavistische Beiträge werden vor allem slavistische Dissertationen des deutschsprachigen Raums sowie vereinzelt auch amerikanische, englische und russische publiziert. Darüber hinaus stellt die Reihe ein Forum für Sammelbände und Monographien etablierter Wissenschafter/innen dar.
    Keywords: have ; Lempp ; Linguistik ; Literaturwissenschaft ; Mieć ; Modern ; Philologie ; Polen ; Polish ; Slavische Sprachwissenschaft ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Tempus und Aspekt im serbokroatischen Praesens (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉In der Reihe 〈I〉Slavistische Beiträge〈/I〉 werden vor allem slavistische Dissertationen des deutschsprachigen Raums sowie vereinzelt auch amerikanische, englische und russische publiziert. Darüber hinaus stellt die Reihe ein Forum für Sammelbände und Monographien etablierter Wissenschafter/innen dar.〈/P〉
    Keywords: Aspekt ; Kroatien ; Linguistik ; Mihailović ; Philologie ; Präsens ; Serbien ; serbokroatischen ; Slavische Sprachwissenschaft ; Tempus ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    L’épidémiologie ou la science de l’estimation du risque en santé publique : Leçon inaugurale prononcée le jeudi 31 (2021)
    Collège de France
    Details
    Publication Date: 2023-12-21
    Description: Peut-on évaluer le risque d’avoir une maladie en lien avec nos gènes, nos comportements ou notre environnement ? L’épidémiologie, qui étudie la répartition et les déterminants des maladies dans la population, permet de répondre à ces questions. Le développement fulgurant de cette science, dans la seconde moitié du xxe siècle, a permis de faire des progrès considérables dans l’identification des facteurs de risque des maladies cardiovasculaires et de nombreux cancers. Les progrès du séquençage du génome humain au début du xxie siècle et, d’une façon plus générale, l’accès aux données massives (big data), ont révolutionné la recherche en épidémiologie tout en lui imposant de nouveaux défis scientifiques et éthiques.
    Keywords: R5-920 ; maladies ; science ; santé ; épidémies ; épidémiologie ; estimation du risque ; santé publique ; bic Book Industry Communication::M Medicine
    Language: French
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    Gramatično izkazanje ob ruskom jeziku (1666) (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Leben und Werk des Kroaten Juraj Križanić (1618 Obrh - 1683 Wien) sind in der slavistischen Forschung Anlaß für zahlreiche Untersuchungen und Beiträge gewesen. Während die biographischen Daten und seine Ideen zum Panslavismus (geäußert in seinen politischen Schriften, besonders in der ' Politika') kaum noch Stoff für neue Erkenntnisse größeren Umfangs bieten, scheint eine ausführlichere Beschäftigung mit den sprachwissenschaftlichen/grammatikalischen Werken noch notwendig, d.h. mit der hier neu abgedruckten Grammatik aus dem Jahre 1666.
    Keywords: 1666 ; 1848 ; besorgt ; Erstausgabe ; Freidhof ; Gerd ; Gramatično ; izkazanje ; jeziku ; kirchenslavisch ; Križanić ; Linguistik ; Nachdruck ; ruskom ; slavische Grammatik ; slavische Mischsparche ; slavische Sprachwissenschaftt ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Controle da tuberculose : uma proposta de integração ensino-serviço (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2024-03-31
    Description: Esta coletânea é especialmente voltada para os profissionais que trabalham na rede do SUS – e pode ser somada a uma proposta de educação a distância. Aborda desde um panorama geral da saúde, no país e no mundo, até os aspectos mais técnicos da tuberculose, como diagnóstico, tratamento e prevenção. Segundo a OMS, o Brasil é um dos 22 países com alta carga de tuberculose e onde o enfrentamento da doença deve ser considerado prioridade. O livro sustenta uma capacitação baseada não só em questões técnicas, mas também em reflexões sobre os determinantes sociais, econômicos e culturais da doença. O objetivo é articular os conteúdos apresentados com a realidade vivenciada pelos profissionais nos serviços de saúde. A 1ª edição é de 1987 e, de lá para cá, o livro já sofreu sucessivas atualizações, envolvendo o Ministério da Saúde, a UFRJ e a Sociedade Brasileira de Pneumologia e Tisiologia, além do Centro de Referência Professor Hélio Fraga (CRPHF), que coordena o trabalho desde o início dos anos 1990. Entre as novidades desta 7ª edição, destacam-se glossário, textos complementares e um projeto gráfico diferenciado para facilitar a leitura e o estudo.
    Keywords: R5-920 ; MEDICAL ; thema EDItEUR::M Medicine and Nursing
    Language: Portuguese
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    Active Aging and Disease Management (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Population aging and the associated burden of chronic diseases are one of the main challenges in public health worldwide. This Research Topic on "Active Aging and Disease Management" provides a comprehensive overview of population aging through fourteen comprehensive papers. Chapter 1 discusses an overview of health systems in active and healthy aging, while Chapter 2 focuses on the role of lifestyles, exercise and new technologies. Chapter 3 debates psychological and cognitive issues in aging and finally in Chapter 4, an older people self assessment is proposed and the role of communities and supporters are highlighted. We think that real social and health care integration at community level could be the key point to deliver effective health promotion and preventive intervention. Enjoy the reading!
    Keywords: R5-920 ; preventing disability ; dietary intake ; Active aging ; chronic diseases ; Life styles ; Mental Health ; Disease Management ; New technologies ; Elderly ; physical activity ; bic Book Industry Communication::M Medicine
    Language: English
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    Sprache und Kognition (2021)
    De Gruyter
    Details
    Publication Date: 2024-03-24
    Description: Is our thinking and thus the worldview the same or language-specific for all people? This book is an unequivocal answer to this age-old question, which was already pursued by Wilhelm von Humboldt: Our worldview is characterized by the grammar of one's mother tongue (s), so that people perceive, verbalise and also remember events in a language-specific way. These basic insights are made possible for the first time by the experimental approach of psycholinguistic methods (such as eye-tracking) selected here. The influence of language on cognition also proves to be extremely relevant to language contact. As a result of the centuries-long language contact between German and Czech, the aspect system of Czech has changed in such a way that event conzeptualization proceeds both in Czech and in German, and that Czech is systematically different from other East and West Slavic languages.
    Description: Ist unser Denken und somit die Weltsicht für alle Menschen gleich oder sprachspezifisch? Auf diese uralte Fragestellung, der bereits Wilhelm von Humboldt nachgegangen ist, gibt dieses Buch eine eindeutig bejahende Antwort: Unsere Weltanschauung wird durch die Grammatik der eigenen Muttersprache(n) geprägt, sodass Menschen Ereignisse sprachspezifisch wahrnehmen, versprachlichen und auch erinnern. Diese grundlegenden Erkenntnisse sind durch den hier gewählten experimentellen Zugang psycholinguistischer Methoden (z.B. Eye-Tracking) erstmalig möglich.Der Einfluss von Sprache auf Kognition erweist sich darüber hinaus für Sprachkontakt als extrem relevant. Infolge des über Jahrhunderte andauernden Sprachkontakts zwischen dem Deutschen und Tschechischen hat sich das Aspekt-System des Tschechischen dahingehend geändert, dass die Ereigniskonzeptualisierung im Tschechischen wie im Deutschen verläuft und das Tschechische sich systematisch von anderen ost- und westslawischen Sprachen absetzt.
    Keywords: Languages ; grammar ; Czech ; German ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFD Psycholinguistics and cognitive linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFD Psycholinguistics and cognitive linguistics::CFDM Bilingualism and multilingualism
    Language: German
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    Poleznyi Dialog (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉In der vorliegenden Arbeit soll untersucht werden, ob und wie der Einsatz sprachlicher Mittel bei der Formulierung von Schlagzeilen abhängig ist von den textsortenbedingten Strukturmerkmalen der zu den Schlagzeilen gehörenden Zeitungstexte. Es werden daher zwei Themen im Zentrum der Überlegungen stehen: journalistische Textsorten und Schlagzeilen. 〈/P〉
    Keywords: Dialog ; ihrer ; Journalistische ; Linguistik ; Poleznyi ; Russland ; Schlagzeilen ; Schneider ; Slavische Sprachwissenschaft ; Spiegel ; Strukturmerkmale ; Textsorten ; Zeitungstexte ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Trauma; Psychosis and Posttraumatic Stress Disorder (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: There is abundant evidence showing a strong association between trauma exposure, psychotic symptoms, and posttraumatic stress disorder (PTSD). Early trauma exposure contributes to the formation of psychotic symptoms and the development of psychotic disorders or severe mental illnesses such as schizophrenia, bipolar disorder, and treatment-refractory major depression. Furthermore, among persons with psychotic disorders, multiple traumatization over the lifetime is common, due to factors such as social stigma, the criminalization of severe mental illness, and increased vulnerability to interpersonal victimization. In addition to these factors is the traumatic nature of experiencing psychotic symptoms and coercive treatments such as involuntary hospitalization and being placed in seclusion or restraints. Not surprisingly, these high rates of trauma lead to high rates of PTSD in people with psychotic disorders, which are associated with more severe symptoms, worse functioning, and greater use of acute care services. In addition to the impact of trauma on the development of psychotic disorders and comorbid PTSD, traumatic experiences such as childhood sexual and physical abuse can shape the nature of prominent psychotic symptoms such as the content of auditory hallucinations and delusional beliefs. Additionally, traumatic experiences have been implicated in the role of ‘stress responsivity’ and increased risk for transition to psychosis in those identified as being at clinical high risk of developing psychosis. Finally, although the diagnostic criteria for PTSD primarily emphasize the effects of trauma on anxiety, avoidance, physiological over-arousal, and negative thoughts, it is well established that PTSD is frequently accompanied by psychotic symptoms such as hallucinations and delusions that cannot be attributed to another DSM-V Axis I disorder such as psychotic depression or schizophrenia. Understanding the contribution of traumatic experiences to the etiology of psychosis and other symptoms can inform the provision of cognitive behavioral therapy for psychosis, including the development of a shared formulation of the events leading up to the onset of the disorder, as well as other trauma-informed treatments that address distressing and disabling symptoms associated with trauma and psychosis. Until recently the trauma treatment needs of this population have been neglected, despite the high rates of trauma and PTSD in persons with psychotic disorders, and in spite of substantial gains made in the treatment of PTSD in the general population. Fortunately, progress in recent years has provided encouraging evidence that PTSD can be effectively treated in people with psychotic disorders using interventions adapted from PTSD treatments developed for the general population. In contrast to clinician fears about the untoward effects of trauma-focused treatments on persons with a psychotic disorder, research indicates that post-traumatic disorders can be safely treated, and that participants frequently experience symptom relief and improved functioning. There is a need to develop a better understanding of the interface between trauma, psychosis, and post-traumatic disorder. This Frontiers Research Topic is devoted to research addressing this interface.
    Keywords: R5-920 ; RC435-571 ; BF1-990 ; Q1-390 ; Psychosis ; PTSD ; Auditory Hallucinations ; Negative Symptoms ; Childhood Trauma ; Trauma ; Psychological Interventions ; Lived Experience ; bic Book Industry Communication::M Medicine
    Language: English
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    Toxoplasmose & Toxoplasma gondii (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: A infecção por Toxoplasma gondii é hoje muito disseminada ao redor do mundo, especialmente no Brasil. A coletânea parte da história da descoberta desse parasita e da doença por ele causada, a toxoplasmose, e visita os diferentes aspectos relacionados ao tema. São apresentados o ciclo evolutivo, a epidemiologia, o diagnóstico, o quadro clínico e o tratamento, em uma ampla revisão sobre o assunto, provavelmente a mais completa já realizada. Somente nos anos 1970 desvendou-se o ciclo de vida desse protozoário, do qual o gato é hospedeiro definitivo. Outros animais de sangue quente, entre eles o ser humano, são hospedeiros intermediários. Muitos indivíduos infectados pelo T. gondii não apresentam sintomas, mas, quando a doença se manifesta, pode ter diferentes configurações, afetando gânglios, olhos, coração, pulmões, fígado, cérebro e meninges, ou articulações. Além de uma completa revisão, a obra também traz para o leitor o que há de mais atual no conhecimento científico acerca da toxoplasmose e do T. gondii. O livro cobre praticamente todos os campos do conhecimento sobre o agente etiológico e a doença, apresentando novos aspectos, particularmente em relação à bioquímica, à interação entre o parasita e a célula hospedeira e à resposta imunológica à infecção.
    Keywords: R5-920 ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Die Struktur der tschechischen Lyrik zu Beginn des 20. Jahrhunderts (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉In der Reihe 〈I〉Slavistische Beiträge〈/I〉 werden vor allem slavistische Dissertationen des deutschsprachigen Raums sowie vereinzelt auch amerikanische, englische und russische publiziert. Darüber hinaus stellt die Reihe ein Forum für Sammelbände und Monographien etablierter Wissenschafter/innen dar.〈/P〉
    Keywords: Beginn ; Frühwerk ; Gellner ; Jahrhunderts ; Linguistik ; Literaturwissenschaft ; Lyrik ; lyrischen ; Philologie ; Sedmidubský ; Slavische Sprachwissenschaft ; Šrámek ; Struktur ; Toman ; Tschechische Republik ; tschechischen ; Untersuchungen ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Russkie vremennye kvantifikatory (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉Die Reihe besteht seit 1980 und setzt ihren Schwerpunkt auf Arbeiten zur theoriebasierten Beschreibung der Grammatik und Lexik slawischer Gegenwartsprachen. Sie umfasst Monographien, thematische Sammelbände und Tagungsbände. 〈/P〉 〈P〉Publiziert wird in jenen slawischen Sprachen, die der Thematik und dem Zielpublikum am besten entsprechen, und darüber hinaus auf Deutsch und Englisch. Publikationsvorschläge und Manuskripte werden vom Herausgeber und einem fachlich kompetenten ExpertInnenkreis begutachtet. 〈/P〉
    Keywords: dovič ; kvantifikatory ; Linguistik ; Philologie ; Russkie ; Russland ; Slavische Sprachwissenschaft ; Slavistik ; vremennye ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Russian
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    Limbic-Brainstem Roles in Perception, Cognition, Emotion and Behavior (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The brainstem-limbic regions, including the superior colliculus, pulvinar and amygdala, receive direct perceptual information as a rapid, coarse, subcortical sensory system bypassing early sensory cortical systems, and play a central role in innate behaviors, including motivated and avoidance behaviors. Recent human neuropsychological studies including those on cortical blindness suggest that these subcortical sensory pathways are functional in the intact human brain and interact with more evolutionary recent cortical systems. This eBook presents up-to-date advancements in this area and to highlight the functions of the brainstem-limbic regions in a variety of perceptual, cognitive, affective and behavioral domains. We hope that this current Research Topic provides a comprehensive review to understand roles of the subcortical brainstem-limbic regions in some forms of sensory-motor coupling, cognitive and affective functions.
    Keywords: R5-920 ; RC321-571 ; RC435-571 ; BF1-990 ; Q1-390 ; Subcortical visual pathway ; Saccades ; Amygdala ; Pulvinar ; Superior colliculus ; Limbic system ; Cognition ; Emotion ; Faces ; Reward and aversion ; bic Book Industry Communication::M Medicine
    Language: English
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    A living history of immunology (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: In the highly competitive world of biomedical science, often the rush to publish and to be recognized as "first" with a new discovery, concept or method, is lost in the hurly-burly of the moment, as "the maddening crowd" moves on to the next "new thing". One of the great things about immunology today is that it has only become mature as a science within the last half-century, and especially within the past 35 years as a consequence of the revolution of molecular immunology, which has taken place only since 1980. Consequently, most of those who have contributed to our new understanding of how the immune system functions are still alive and well, and still contributing. Thus, "A Living History of Immunology" collates many stories from the investigators who actually performed the experiments that have established the frontiers of immunology. Accordingly, this volume combats "revisionist science", by those who want to alter history by telling the stories a different way than actually happened. In this regard, one of the good things about science vs. other disciplines is that we have the written record of what was done, when it was done and by whom. Even so, we do not have the complete story or narrative of how and why experiments were done, and what made the differences that led to success. This volume captures and chronicles some of these stories from the past fifty years in immunology.
    Keywords: R5-920 ; RC581-607 ; cytotoxic T lymphocytes (CTL) ; antibody ; Interleukins ; immunology history ; B cells ; Macrophages ; T cells ; Antibody Forming Cells (AFC) ; Thymus ; T cell receptor (TCR) ; bic Book Industry Communication::M Medicine
    Language: English
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    Disclosure Within HIV-Affected Families (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: While HIV/AIDS is a global public heath challenge, its impact is arguably greatest in the Sub-Saharan Africa (SSA), where new infections account for approximately 66% of the total number of HIV-positive persons globally. In SSA, medical, social, and economic resources are limited, thus necessitating innovative approaches to disease prevention. One of the mechanisms of prevention that is most promising occurs through HIV disclosure to family members (e.g., adult sexual partners) generally, and to children in particular. Our emphasis in this eBook is on HIV disclosure to children because it has multiple benefits, including improved adherence to antiretroviral medication treatment and understanding at an early age of the impact of sexual activity on the spread of HIV. While there is a noticeable gap in research on HIV disclosure to younger children, some of the general reasons for non-disclosure include concerns about fear of adult partners leaving relationships, and that children are too young to comprehend the severity of the situation and may tell others outside the family. Thus, it is critical to better understand how the HIV disclosure process happens (or does not happen) within HIV-affected families, as well as the best practices on how to disclose. In this eBook, we present a combination of empirical research studies and critical literature reviews that investigate the reasons for and for not disclosing HIV status within HIV-affected families and provide evidence-based practices that could be adopted by healthcare professionals to help HIV-positive parents facilitate disclosure activities within these families. This information can also be used by researchers, practitioners, and stakeholders who are in a position to influence policies on effective HIV disclosure practices, guidelines, and programs.
    Keywords: R5-920 ; RA1-1270 ; HIVAIDS ; Resource-poor setting ; HIV disclosure ; Parental HIV status disclosure ; Sub-Saharan Africa (SSA) ; Child HIV status disclosure ; HIV disclosure process ; bic Book Industry Communication::M Medicine
    Language: English
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    Valenz im ,Smysl-Tekst'-Modell (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Für die Zielsetzung der vorliegenden Studie sind die Arbeiten Apresjans, die nach seinem Anschluß an den sog. Moskauer Semantisehen Zirkel um die beiden Linguisten I. A. Mel'čuk und A. K. Zolkovskij entstanden sind, von besonderem Interesse (zur Geschichte der linguistischen Schule s. Mel'čuk 1980; Weiss 1984). Der Moskauer Semantische Zirkel hat in den 60-er und 70-er Jahren eine eigenständige Sprachtheorie, die sog. 'Smysl-Tekst'-Theorie hervorgebracht. In ihren allgemeinen Zügen präsentiert sich diese Theorie als ein mehrstufiges Grammatikmodell, das auf seinen verschiedenen Beschreibungsebenen durchgängig die Valenztheorie verwendet (s. Mel'čuk 1974).
    Keywords: Analyse ; Eine ; Intentionalität und Kausation ; konfrontative ; Modell ; Pantel ; polnischer ; Rektionsmodell ; russischer ; semantische Valenz ; Smysl ; syntaktische Valenz ; Tekst ; Valenz ; Valenzbegriff ; Verben ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    O clássico e o novo - tendências, objetos e abordagens em ciências sociais e saúde (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Tratando de temas, como a cultura e a subjetividade, as questões éticas da atualidade, a qualidade de vida no mundo contemporâneo etc., O Clássico e o Novo é o fruto de trabalhos apresentados no 2o Congresso Brasileiro de Ciências Sociais em Saúde, e reúne uma gama dos mais qualificados profissionais que tratam de diferentes temas, intencionando uma perspectiva multidisciplinar. Partindo do pressuposto de que dentro da própria área das Ciências Sociais há um processo de fragmentação que vem exigindo cada vez mais novas interlocuções interdisciplinares, procura-se aqui estabelecer um diálogo profícuo entre este campo do saber e a área da saúde. Dessa forma, ao abordar questões relacionadas à área da saúde, este livro se constitui como leitura obrigatória para os profissionais de saúde coletiva, introduzindo diferentes e instigantes propostas de reflexão para a saúde na atualidade.
    Keywords: R5-920 ; Qualidade de vida ; Política de saúde ; Iniquidade na saúde ; Política social ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Violência e saúde (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Neste livro, a autora busca introduzir uma reflexão sobre as articulações entre o tema da violência e suas repercussões na saúde dos brasileiros, por meio da conceituação da violência no campo sociológico, da sua articulação com a saúde e de propostas de atuação. A discussão abrange aspectos históricos, culturais, sociológicos e econômicos, considerando que em suas relações a violência se apresenta ora como manifestação da dinâmica e da trajetória de uma sociedade, ora como fenômeno específico que se destaca e influencia essa mesma dinâmica social.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Gluten-Free Diet (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.
    Keywords: R5-920 ; RC620-627 ; gluten ; n/a ; mental health ; 33-mer ; gut motility ; gluten re-introduction ; teenagers ; gastric emptying ; islet of Langerhans ; children ; high-fat diet-induced obesity ; affective disorders ; FODMAP intake ; Brazilian CD-QoL ; DQ2.5-glia-?3 epitopes ; place of residence ; zinc ; glutenin ; quality of life (QoL) ; mood disorders ; magnesium ; dietary adherence ; coeliac disease ; food habit ; villous atrophy ; pepsin ; peptides derived from gluten in faeces and urine ; beta cell ; body mass index (BMI) ; oral food challenge ; gliadin ; ?-gliadin ; non-celiac gluten sensitivity ; celiac disease ; wheat ; outcome ; DQ2.5-glia-?1 ; DQ2.5-glia-?2 ; gut microbiota ; type 2 diabetes ; major depressive disorder ; micronutrient ; beta-cell stress ; non-coeliac gluten sensitivity ; screening ; gluten free diet ; gluten-related disorders ; threshold ; diary recommended intake ; wheat species ; non-coeliac wheat sensitivity ; body composition ; serology ; educational level ; mineral ; disease duration ; gastrointestinal symptoms ; gluten-free diet ; NOD mouse ; diagnosis ; osteoporosis ; nutrition ; cholecyst ; wheat allergy ; celiac disease (CD) ; quality of life ; microbiota ; questionnaire ; nutritionists ; structured questionnaires ; Pseudomonas ; intestinal permeability ; Celiac Disease ; economic status ; effectiveness ; type 1 diabetes ; cost ; calcium ; irritable bowel syndrome ; adherence ; non celiac gluten sensitivity ; deficiency ; gluten sensitivity ; iron ; low FODMAP diet ; depression ; clinic ; duodenal biopsies ; fortification ; mucosal recovery ; bic Book Industry Communication::M Medicine
    Language: English
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    Optical Methods in Sensing and Imaging for Medical and Biological Applications (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: The recent advances in optical sources and detectors have opened up new opportunities for sensing and imaging techniques which can be successfully used in biomedical and healthcare applications. This book, entitled ‘Optical Methods in Sensing and Imaging for Medical and Biological Applications’, focuses on various aspects of the research and development related to these areas. The book will be a valuable source of information presenting the recent advances in optical methods and novel techniques, as well as their applications in the fields of biomedicine and healthcare, to anyone interested in this subject.
    Keywords: R5-920 ; TA1-2040 ; RM1-950 ; fiber optic sensor ; computational optical sensing and imaging ; imaging spectroscopy ; spectral imaging ; optical coherent tomography ; optical feedback interferometry ; optical tomography ; Raman sensing and imaging ; bic Book Industry Communication::M Medicine
    Language: English
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