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  • Articles  (1,303)
  • American Meteorological Society
  • American Society of Hematology
  • 2020-2022  (1,303)
  • 2021  (1,303)
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  • 2021  (1,303)
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  • 1
    Publication Date: 2021-05-12
    Description: Producing probabilistic subseasonal forecasts of extreme events up to six weeks in advance is crucial for many economic sectors. In agribusiness, this time scale is particularly critical because it allows for mitigation strategies to be adopted for counteracting weather hazards and taking advantage of opportunities. For example, spring frosts are detrimental for many nut trees, resulting in dramatic losses at harvest time. To explore subseasonal forecast quality in boreal spring, identified as one of the most sensitive times of the year by agribusiness end users, we build a multisystem ensemble using four models involved in the Subseasonal to Seasonal Prediction project (S2S). Two-meter temperature forecasts are used to analyze cold spell predictions in the coastal Black Sea region, an area that is a global leader in the production of hazelnuts. When analyzed at the global scale, the multisystem ensemble probabilistic forecasts for near-surface temperature are better than climatological values for several regions, especially the tropics, even many weeks in advance; however, in the coastal Black Sea, skill is low after the second forecast week. When cold spells are predicted instead of near-surface temperatures, skill improves for the region, and the forecasts prove to contain potentially useful information to stakeholders willing to put mitigation plans into effect. Using a cost–loss model approach for the first time in this context, we show that there is added value of having such a forecast system instead of a business-as-usual strategy, not only for predictions released 1–2 weeks ahead of the extreme event, but also at longer lead times.
    Description: Published
    Description: 237–254
    Description: 4A. Oceanografia e clima
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
    Publication Date: 2021-08-20
    Description: In 2007 and 2009 the regulatory approval of the first-in-class complement inhibitor Eculizumab has revolutionized the clinical management of two rare, life-threatening clinical conditions: paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). While being completely distinct diseases affecting blood cells and the glomerulus, PNH and aHUS remarkably share several features in their etiology and clinical presentation. An imbalance between complement activation and regulation at host surfaces underlies both diseases precipitating in severe thrombotic events that are largely resistant to anti-coagulant and/or anti-platelet therapies. Inhibition of the common terminal complement pathway by Eculizumab prevents the frequently occurring thrombotic events responsible for the high mortality and morbidity observed in patients not treated with anti-complement therapy. While many in vitro and ex vivo studies elaborate numerous different molecular interactions between complement activation products and hemostasis, this review focuses on the clinical evidence that links these two fields in humans. Several non-infectious conditions with known complement involvement are scrutinized for common patterns concerning a prothrombotic statues and the occurrence of certain complement activation levels. Next to PNH and aHUS, germline encoded CD59 or CD55 deficiency (the latter causing the disease Complement Hyperactivation, Angiopathic thrombosis, and Protein-Losing Enteropathy; CHAPLE), autoimmune hemolytic anemia (AIHA), (catastrophic) anti-phospholipid syndrome (APS, CAPS) and C3 glomerulopathy are considered. Parallels and distinct features among these conditions are discussed against the background of thrombosis, complement activation, and potential complement diagnostic and therapeutic avenues.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 3
    Publication Date: 2021-08-20
    Description: Exposure of blood to a foreign surface in the form of a diagnostic or therapeutic biomaterial device or implanted cells or tissues, elicits an immediate, evolutionarily conserved thrombo-inflammatory response by the host. Primarily designed to protect against invading organisms following an injury, this innate response features instantaneous activation of several blood-borne, highly interactive and well-orchestrated cascades and cellular events that limit bleeding, destroy and eliminate the foreign substance/cells, and promote healing and a return to homeostasis via delicately balanced regenerative processes. In the setting of blood-contacting synthetic or natural biomaterials and implantation of foreign cells/tissues, innate responses are robust, albeit highly context-specific. Unfortunately, they tend to be less than adequately regulated by the host's natural anti-coagulant/anti-inflammatory pathways, thereby jeopardizing the functional integrity of the device, as well as the health of the host. Strategies to achieve biocompatibility with a sustained return to homeostasis, particularly while the device remains in situ and functional, continue to elude scientists and clinicians. In this review, some of the complex mechanisms by which biomaterials and cellular transplants provide a "hub" for activation and amplification of coagulation and immunity - thrombo-inflammation - will be discussed, with a view toward the development of innovative means of overcoming the innate challenges.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 4
    Publication Date: 2021-02-01
    Description: Multiyear climate predictions provide climate outlooks from years to a decade in advance. As multiyear temperature predictions become more mainstream and skillful, guidance is needed to assist practitioners who wish to explore this maturing field. This paper demonstrates the process and considerations of incorporating multiyear temperature predictions into water resources planning. Multiyear temperature predictions from the Community Earth System Model Decadal Prediction Large Ensemble are presented as discrete and probabilistic products and are used to force two common hydrologic modeling approaches: conceptual and empirical. The approaches are demonstrated to simulate streamflow in the upper Colorado River basin watershed in Colorado, where diagnostics show that increasing temperatures are associated with decreasing streamflows. Using temperature information for lead years 2–6, two analyses are performed: (i) a retrospective hindcast for the climatological period (1981–2010) and (ii) a blind forecast for 2011–15. For the retrospective hindcast, including temperature information improved the percent error as compared with climatology. For the blind forecast, the multiyear temperature prediction for warming was skillful, but the corresponding multiyear average streamflow predictions from both approaches were counterintuitive: with the predicted warming, the multiyear average streamflow was predicted to be lower than the climatological mean; however, the observed multiyear average streamflow was higher than the climatological mean. This was due to above-average precipitation during the prediction time frame, particularly for one of the years. With that year removed, the multiyear streamflow average became lower than the climatological mean. Temperature provides a marginal source of streamflow predictability, but there will be substantial uncertainty until prediction skill for year-to-year climate variability, especially for precipitation, increases.
    Print ISSN: 1558-8424
    Electronic ISSN: 1558-8432
    Topics: Geography , Physics
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  • 5
    Publication Date: 2021-02-25
    Description: Previous studies have concluded that the wind-input vorticity in ocean gyres is balanced by bottom pressure torques (BPT), when integrated over latitude bands. However, the BPT must vanish when integrated over any area enclosed by an isobath. This constraint raises ambiguities regarding the regions over which BPT should close the vorticity budget, and implies that BPT generated to balance a local wind stress curl necessitates the generation of a compensating, non-local BPT and thus non-local circulation. This study aims to clarify the role of BPT in wind-driven gyres using an idealized isopycnal model. Experiments performed with a single-signed wind stress curl in an enclosed, sloped basin reveal that BPT balances the winds only when integrated over latitude bands. Integrating over other, dynamically-motivated definitions of the gyre, such as barotropic streamlines, yields a balance between wind stress curl and bottom frictional torques. This implies that bottom friction plays a non-negligible role in structuring the gyre circulation. Non-local bottom pressure torques manifest in the form of along-slope pressure gradients associated with a weak basin-scale circulation, and are associated with a transition to a balance between wind stress and bottom friction around the coasts. Finally, a suite of perturbation experiments is used to investigate the dynamics of BPT. To predict the BPT, the authors extend previous theory that describes propagation of surface pressure signals from the gyre interior toward the coast along planetary potential vorticity contours. This theory is shown to agree closely with the diagnosed contributions to the vorticity budget across the suite of model experiments.
    Print ISSN: 0022-3670
    Electronic ISSN: 1520-0485
    Topics: Geosciences , Physics
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  • 6
    Publication Date: 2021-02-25
    Description: Sufficient and accurate tide data are essential for analyzing physical processes in the ocean. A method is developed to spatially fit the tidal amplitude and phase lag data along satellite altimeter tracks near Hawaii and construct reliable cotidal charts by using the Chebyshev polynomials. The method is completely dependent on satellite altimeter data. By using the cross-validation method, the optimal orders of Chebyshev polynomials are determined and the polynomial coefficients are calculated by the least squares method. The tidal amplitudes and phase lags obtained by the method are compared with those from the Finite Element Solutions 2014 (FES2014), National Astronomical Observatory 99b (NAO.99b) and TPXO9 models. Results indicate that the method yields accurate results as its fitting results are consistent with the harmonic constants of the three models. The feasibility of this method is also validated by the harmonic constants from tidal gauges near Hawaii.
    Print ISSN: 0739-0572
    Electronic ISSN: 1520-0426
    Topics: Geography , Geosciences , Physics
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  • 7
    Publication Date: 2021-02-25
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 8
    Publication Date: 2021-02-25
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 9
    Publication Date: 2021-02-25
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 10
    Publication Date: 2021-02-25
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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