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  • Frontiers Media SA  (2,462)
  • American Chemical Society  (1,737)
  • Cham :Springer International Publishing :  (1,735)
  • Cambridge University Press
  • Nature Publishing Group (NPG)
  • 2020-2024  (6,204)
  • 1960-1964
  • 2022  (1,046)
  • 2021  (5,158)
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Year
  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Reproduction. ; Physiology. ; Anatomy. ; Cytology. ; Human Physiology. ; Reproductive Physiology. ; Anatomy. ; Cell Biology.
    Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: Origin and development of the breast -- Chapter 3: Structure of the lactating breast -- Chapter 4: Breast function during the initial period of lactation (lactogenesis I and II) -- Chapter 5: The period of established lactation (lactogenesis III).
    Abstract: This comprehensive Monograph examines all peripheral and central mechanisms of regulating the secretion of milk from the lactating breast. The author reviews the complete female breast development, starting with the early childhood, up to pregnancy and lactation. Structural and ultrastructural data on the alveolar-ductal system, together with details of breast innervation, are used to investigate the physiological process of lactation. Readers will appreciate the special focus on reflexes, both in the child and the mother, that help to regulate maternal milk production and secretion. Following this, the author sheds a light on the composition and dynamics of milk components during the different periods of lactation. The final section of this volume focusses on practical aspects of modern breastfeeding, like the use of breast pumps or galactogogues, to influence the productivity of milk production. These fundamental principles and structural details will be particularly useful for physiologists and clinicians working in gynecology and pediatrics.
    Type of Medium: Online Resource
    Pages: VIII, 254 p. 87 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030663643
    DDC: 612
    Language: English
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  • 2
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    DDC: 615
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Biotechnology. ; Enzymology. ; Bioorganic chemistry. ; Protein Biochemistry. ; Chemical Bioengineering. ; Enzymology. ; Bioorganic Chemistry.
    Description / Table of Contents: Preface -- Chapter 1: Introduction -- Chapter 2: Enzyme Cascade Design – Retrosynthesis Approach -- Chapter 3 : Multi-Enzymatic Cascades in vitro -- Chapter 4: Multi-Enzymatic Cascades in vivo -- Chapter 5: Chemo-Enzymatic Cascades -- Chapter 6: Enzyme Cascade Kinetic Modelling -- Chapter 7: Enzyme Cascade Reaction Engineering -- Chapter 8: Enzyme Cascade Process Design and Modelling -- Chapter 9: Enzyme Cascade Reaction Monitoring And Control -- Chapter 10: Cascade reactions in non-conventional media -- Chapter 11: Perspectives.
    Abstract: This book provides a comprehensive overview of the recent developments achieved in the field of chemo/enzymatic cascades with topics spanning from design (in vitro and in vivo) to kinetic- and process modelling as well as process control. Opportunities and challenges of building multi-step chemo/enzymatic reactions are discussed, whereby the latter are critically assessed in each chapter and methods to ease the implementation are explored. Both, multi-enzymatic cascades and chemo-enzymatic cascades are presented with the motivation of combining the strengths of these two worlds (e.g. selectivity, activity and robustness) not neglecting the obstacles and challenges of such endeavour. Furthermore, the use of non-conventional media for catalytic cascade reactions, recent achievements and potential for future developments in a technical environment are addressed.
    Type of Medium: Online Resource
    Pages: VII, 181 p. 103 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030657185
    DDC: 572.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Radiology. ; Spectrum analysis. ; Pharmaceutical chemistry. ; Nutrition   . ; Biomedical Research. ; Radiology. ; Spectroscopy. ; Pharmaceutics. ; Nutrition.
    Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.
    Abstract: This book introduces the audience with basic theoretical and experimental aspects of Electron Spin Resonance (ESR) Spectroscopy. It further talks about ESR spectroscopy applications in Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science. Mathematical details have been kept to a necessary minimum and emphasis is given to highlight the applications of the technique.
    Type of Medium: Online Resource
    Pages: X, 72 p. 32 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641986
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 610.72
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biochemistry. ; Renewable energy sources. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Sustainability. ; Biochemistry. ; Renewable Energy. ; Environmental Engineering/Biotechnology. ; Sustainability.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Fractionation strategies -- Chapter 3. Biochemical conversion of cellulose -- Chapter 4. Biochemical conversion of hemicellulose -- Chapter 5. Biochemical conversion of lignin -- Chapter 6. Thermochemical conversion of cellulose and hemicellulose -- Chapter 7. Thermochemical conversion of lignin -- Chapter 8. Material application of lignin -- Chapter 9. TEA for evaluating biorefinery strategies.
    Abstract: This book focuses on the technologies developed for the conversion of all three biomass components, i.e. cellulose, hemicellulose and lignin, and their constituents, to fuels and high-value products. Both biochemical and thermochemical approaches are reviewed. Additionally, the developed technologies are described in detail and their potential applications as well as their commercial status are discussed. The early attempts to produce fuel ethanol from lignocellulosic biomass feedstock focused solely on the biological conversion of cellulose because the only organism that had been used successfully for commercial production of ethanol, i.e. Saccharomyces cerevisiae, could only ferment glucose, which was obtained from the hydrolysis of cellulose. Hemicellulose and lignin were considered as wastes in these processes and were normally removed in pretreatment processes to enhance enzymatic hydrolysis of the remaining cellulose. However, this approach was not economically feasible and as a result, the biorefinery concept was developed. In a biorefinery, in addition to ethanol, various higher-value products are produced from hemicellulose and lignin, which were previously not considered. Consequently, technologies were developed for the fractionation of biomass and conversion of hemicellulose and lignin to fuels and high-value products to improve the economic feasibility. Written and edited by a team of investigators with many years of experience in biomass processing research and development, this book is an informative resource for postgraduate students and researchers interested in biorefinery and biofuel technologies both in academia- and commercial laboratories.
    Type of Medium: Online Resource
    Pages: IX, 245 p. 43 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031058356
    DDC: 572
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Botanical chemistry. ; Plant physiology. ; Agriculture. ; Plant Science. ; Plant Biochemistry. ; Plant Physiology. ; Agriculture.
    Description / Table of Contents: How the three organ-produced signals: auxin, cytokinin and gibberellin, induce and regulate wood formation and adaptation -- Role of plant growth regulators in the plant-environment interaction and epigenetic regulation of auxin -- The role of auxin and cytokinin signaling components in de novo shoot organogenesis -- Mechanism of crosstalk between cytokinin and gibberellin -- In vitro responses of some Mediterranean fruit crops to auxin, cytokinin and gibberellin treatments -- Integrative approach of the root architecture by interaction between auxin and nutrients -- Insights into Biosynthesis and Signaling of Cytokinins during Plant Growth, Development and Stress Tolerance -- Cytokinin signaling in plants under salt stress -- Auxin and Cytokinin Signaling in Plant Stress Response -- Gibberellins' cross talk and signal transduction in plant stress response -- Crosstalk between Salicylic acid and Auxins, Cytokinins and Gibberellins under biotic stress -- Understanding the crosstalk between chromatin remodeling mechanism and phytohormones signaling for maintenance of plant developmental plasticity: an insight -- Phytohormone-mediated regulation of sprouting in tuber and storage root crops -- Role of phytohormones in plant-microbial interaction -- Iron toxicity tolerance in rice: roles of auxins and gibberellins -- New auxin and cytokinin related compounds based on synthetic low molecular weight heterocycles.
    Abstract: Plant hormones have pivotal roles in the regulation of plant growth, development, and reproduction. Their signaling pathways are interconnected in a complex network, which provides plants with an enormous regulatory potential to rapidly adapt to their environment and to utilize their limited resources for growth and survival in a cost-efficient manner. Auxin is a hormone molecule whose activity levels are most important for its regulatory roles during plant cell, organ, and tissue development. Therefore, the precise regulation of auxin levels is an essential mechanism to fine-tune the activity of this powerful hormone during plant growth and development. Likewise, cytokinins exhibit a wide range of physiological functions, including regulation of shoot and root apical meristems, stimulation of branching, vascular development, chloroplast differentiation, stabilization of the structure and function of the photosynthetic machinery, delay of senescence, stomata opening, and elevation of the sink strength and nutritional signaling. Moreover, gibberellins also regulate many aspects of plant growth and development including seed germination, stem elongation, leaf expansion, and flower and fruit development. The broad implication of gibberellins in plant development is strictly associated with tight regulation of their metabolism by multiple environmental and endogenous factors, ranging from light and temperature to other hormones including feedback control. Understanding the significant roles of these phytohormones in plant biology, the current subject has attracted the attention of scientists from across the globe. This comprehensive volume “Auxins, Cytokinins and Gibberellins Signaling in Plants” highlights the various prospects involved in the current scenario. The book comprises the chapters from diverse areas dealing with biotechnology, molecular biology, proteomics, genomics, metabolomics, etc.
    Type of Medium: Online Resource
    Pages: IX, 377 p. 63 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031054273
    Series Statement: Signaling and Communication in Plants,
    DDC: 580
    Language: English
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  • 7
    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    DDC: 615
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant anatomy. ; Plant physiology. ; Landscape architecture. ; Plant diseases. ; Agriculture. ; Plant Anatomy and Morphology. ; Plant Physiology. ; Landscape Architecture. ; Plant Pathology. ; Agriculture.
    Description / Table of Contents: Preface -- Introduction -- 1. Nomenclature -- 2. Lycopods And Monilophytes -- 3. Gymnosperms -- 4. Angiosperms: Flowering Plants -- Index.
    Abstract: Horticulture has remained far behind in understanding of botanical principles. Recent phylogenetic (DNA-based) reorganization of higher plants has revolutionized taxonomic treatments of all biological entities, even when morphology does not completely agree with their organization. This book is an example of applying principals of botanical phylogenetic taxonomy to assemble genera, species, and cultivars of 200 vascular plant families of ferns, gymnosperms, and angiosperms that are cultivated for enhancement of human living space; homes, gardens, and parks. The emphases are on cultivated species but examples of some plants are often shown in the wild and in landscapes. In providing descriptions, it is assumed that students and other interested individuals have no background in general botany (plant characteristics), or nomenclature. Fundamental features of all plant groups discussed are fully illustrated by original watercolor drawings or photographs. Discussion of the families is grounded on recent botanical phylogenetic treatments, which is based on common ancestry (monophyly). Of course, phylogenetic taxonomy is not a new concept, and was originally based on morphological characteristics; it is the DNA-based phylogeny that has revolutionized modern biological classifications. In practical terms, this book represents the horticultural treatment that corresponds to phylogenetic-based botanical taxonomy, to which is added cultigens and cultivated genera and species. Hence, the harmony between horticultural and botanical taxonomy. This book covers phylogenetic-based taxonomy of Ferns, Gymnosperms, and Angiosperms (Monocots). A companion volume covers Angiosperms (Eudicots).
    Type of Medium: Online Resource
    Pages: XXV, 700 p. 551 illus., 549 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031115615
    DDC: 571.32
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical policy. ; Quality of life. ; Biomedical Research. ; Health Policy. ; Quality of Life Research.
    Description / Table of Contents: Foreword: Challenges & Opportunities for LGBT Populations and Cancer in Global Oncology -- Introduction -- Africa -- A Double Dose Of Stigma – Being Gay And Living With Cancer In Kenya -- Sexual Orientation, Gender Identity and Cancer in South Africa -- Americas -- Making the Situation of TLGBI People around Cancer visible: Observations from the Andean Region -- Cancer Care Challenges for the LGBT Population in Brazil -- Cancer and the SGM Population in Canada and the United States of America -- South-East Asia -- The South-East Asia Region: Societal Conditions for LGBT Health and Cancer Research -- Europe -- Foreword: The Eurocentralasian Lesbian* Community Perspective on Cancer and LBQ women: Advocating for more Research and Activism Collaboration -- LGBT+ and Cancer in the WHO European Region: Current Situation in 12 Eastern European and Central Asian Countries -- Sexual and Gender Minorities and Cancer in Germany: The Striking Absence of Understanding their Cancer-related Needs -- LGBT Populations and Cancer in the UK -- Eastern Mediterranean -- LGBT Populations and Cancer in the Eastern Mediterranean Region: Insights and Challenges with a Focus on Lebanon -- Western Pacific -- LGBT Populations and Cancer in Australia and New Zealand -- Challenges in Cancer Control Confronting the LGBT Population in China: Health Risks, Unique Barriers, and Unmet Needs -- What Have We Learned about Cancer and the Global LGBT Community? -- Index.
    Abstract: Lesbian, Gay, Bisexual, and Transgender (LGBT) also known as sexual and gender minority (SGM) populations have been the focus of global attention. Most importantly, LGBT populations have been addressed in the context of human rights in multiple reports and other activities by the United Nations and other international organizations. There is great variation among countries in the recognition of LGBT individuals’ human rights. A global focus on LGBT populations’ health is still limited, with the notable exception of HIV research. This book on LGBT populations and cancer in the global context is, therefore, an important step in that it will broaden the focus on LGBT populations’ health. Globally, cancer is the second leading cause of death. Cancer morbidity and mortality are increasing disproportionately among populations in lower-income countries. A review conducted by the World Health Organization (WHO) found that of the 82% of member states (158) countries, only 35% of the national cancer control plans addresses vulnerable population, including LGBT populations. These findings reflect an increasing awareness about equity when addressing cancer prevention and control, including LGBT populations. This book addresses LGBT populations’ cancer burden across countries that range from high- to low-income countries to support efforts in diverse countries that are working towards reducing LGBT populations’ cancer burden. It documents place-specific challenges that impede progress towards reducing the LGBT cancer burden as well as critically assesses the variation in cancer control efforts that target LGBT populations and cancer to support progress at a global scale. This book includes six sections that cover the six WHO regions, with each chapter written by an author from the specific region s/he is covering. Each chapter makes use of a template that contextualizes the region, local data collection/availability, risk factors, cancer prevention, detection, diagnosis, treatment, and survivorship.
    Type of Medium: Online Resource
    Pages: X, 335 p. 3 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031065859
    DDC: 610.72
    Language: English
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  • 10
    Keywords: Agriculture. ; Nutrition   . ; Animal biotechnology. ; Agriculture. ; Nutrition. ; Animal Biotechnology.
    Description / Table of Contents: Preface -- 1. Impact of sex steroids on the stress response and welfare in female farm ruminants (Aline Freitas-de-Melo and Rodolfo Ungerfeld) -- 2. Insights from proteomics in kidney disease diagnosis and various in vitro and in vivo experimental models (Vikram Patial, Garima Dadhich, and Rajiv Kumar) -- 3. Generation of gene edited pigs (S. Navarro-Serna, C. Piñeiro-Silva, R Romar, J. Parrington, and J Gadea) -- 4. Dietary anti-nutritional factors and their roles in livestock nutrition (Salma H. Abu Hafsa, Ayman A. Hassan, Mona M.MY. Elghandour, Alberto Barbabosa-Pliego, Miguel Mellado, and Abdelfattah Z.M. Salem) -- 5. Genetic engineering tools and techniques in livestock production (Ranjitha H.B., Madhu Ramesh, Subhasmita Behera, Dhanesh ValiyaValappil, Suresh H. Basagoudanavar, and Anjum Sherasiya) -- 6. Mineral Ions in Regulation of Hypothalamic-Pituitary-Ovarian Axis (Mustafa Hassan Jan, Harpreet Singh, and Shikha Kapil) -- 7. Molecular Insights of Compromised Female Reproduction in Ruminants under Metabolic and Nutritional Stress (S. Nandi, S. K Tripathi, PSP Gupta, and S. Mondal) -- Index.
    Abstract: This 2nd book provides fundamental concepts and recent applications of biotechnological methods, such as genetic selection, breeding methods and genetic engineering tools. Biotechnology has remarkably improved the productivity of livestock by increasing the reproduction efficiency and decreasing the generation time. The chapters detail the mechanisms of methods for animal reproduction and breeding methods. This book focus on the impact of minerals, steroids metabolic stress, nutritional stress and anti-nutritional factors on the livestock reproduction.
    Type of Medium: Online Resource
    Pages: XV, 255 p. 32 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031074967
    Series Statement: Sustainable Agriculture Reviews, 57
    DDC: 630
    Language: English
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  • 11
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biology. ; Pharmaceutical chemistry. ; Biochemistry. ; Pharmacology. ; Cytology. ; Biological Sciences. ; Pharmaceutics. ; Biological Chemistry. ; Pharmacology. ; Cell Biology.
    Description / Table of Contents: Bioanalytical Support in Drug Discovery and Development,- Monoclonal Antibodies -- Antibody Drug Conjugates (ADCS) -- Bispecifics and Fusion Proteins -- Emerging Modalities-Part A- (Gene Therapy and Cell Therapy) -- Emerging Modalities Part B (Peptides, Oligonucleotide Based Therapy, Vaccines. .
    Abstract: The book provides a comprehensive review of the fundamental and practical aspects of bioanalytical support and the integral role it plays in the development of safe and efficacious biopharmaceutical drugs with speed and cost-effectiveness. The book focuses on a broad range of conventional and emerging biopharmaceutical modalities including monoclonal antibody-based therapeutics, gene therapy, cell therapy, peptides and oligonucleotides. The book starts with an introductory overview of bioanalysis showcasing the integral role it plays in understanding the drug disposition (pharmacokinetics/pharmacodynamics and immunogenicity) and the progression of bioanalytical strategy as the drug progresses through discovery and development stages of the program, taking into consideration the continually evolving regulatory landscape. The book further diversifies into individual biopharmaceutical modalities - monoclonal antibodies, antibody-drug conjugates, bispecifics, Fc-fusion proteins, gene therapies, cell therapies, peptides and oligonucleotides. The individual chapters focus on modality-specific bioanalytical assay strategies, critical reagents, assay formats, analytical platforms, associated bioanalytical challenges and mitigation strategies, industry best practices, and the latest understanding of regulatory guidance as applicable to the fast-growing biopharmaceutical landscape.
    Type of Medium: Online Resource
    Pages: IX, 160 p. 25 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030971939
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 57
    DDC: 570
    Language: English
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  • 12
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Evolution (Biology). ; Biology Philosophy. ; Linguistics. ; Cognitive science. ; Cognitive psychology. ; Evolutionary Biology. ; Philosophy of Biology. ; Linguistics. ; Cognitive Science. ; Cognitive Psychology.
    Description / Table of Contents: Narrative and persuasion -- Two models of communication -- Beyond the social brain -- The narrative brain -- Stories without language.
    Abstract: This book explores the evolutionary and cognitive foundations of human communication, focusing on narrative as its distinctive dimension. Within a framework of continuity with both the communication of our hominin predecessors and that of non-human animals, the book is about a twofold proposal. It includes the idea that (human and animal) communication has an intrinsically persuasive nature along with the hypothesis that humans developed narrative forms of communication in order to enhance their persuasive abilities. In this view, narrative persuasion becomes the feature that distinguishes human communication from animal communication. The study of the transition from animal communication to language addresses both the selective pressures that led communication for persuasive purposes to take a narrative form and the cognitive architectures and expressive systems that enabled our ancestors to cope with the selective pressures of persuasive/narrative-based communication. Language evolution is interdisciplinary, even from the specific perspective of evolutionary pragmatics chosen here. Therefore, this book is intended for researchers working in fields such as cognitive sciences, philosophy, evolutionary biology, cognitive psychology, and primatology. It also represents a valuable resource for advanced students in cognitive sciences, linguistics, and philosophy.
    Type of Medium: Online Resource
    Pages: XIII, 138 p. 3 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031092060
    Series Statement: Interdisciplinary Evolution Research, 7
    DDC: 576.8
    Language: English
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  • 13
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Plant biotechnology. ; Pharmaceutical chemistry. ; Agriculture. ; Proteins . ; Plant Science. ; Plant Biotechnology. ; Pharmaceutics. ; Agriculture. ; Protein Biochemistry.
    Description / Table of Contents: Chapter. 1. Molecular Farming in Plants: Introduction and Applications -- Chapter. 2. Tools and Techniques Used in Plant Molecular Farming -- Chapter. 3. Production of plant natural products in heterologous microbial species -- Chapter. 4. Sustainable Manufacturing of Vaccines, Antibodies, and other Pharmaceuticals -- Chapter. 5. Limitations, Biosafety, ethics, regulatory issues in molecular farming in plants -- Chapter. 6. Conclusion and Perspectives.
    Abstract: Molecular farming is a biotechnological approach that includes the genetic adjustment of agricultural products to create proteins and chemicals for profitable and pharmaceutical purposes. Plant molecular farming describes the manufacture of recombinant proteins and other biologically active product in plants. This approach depends on a genetic transformation of plants that can be accomplished by the methods of stable gene transfer, such as gene transfer to nuclei and chloroplasts, and unstable transfer methods like viral vectors. The requirement for recombinant proteins in terms of quality, quantity, and diversity is increasing exponentially This demand is traditionally met by recombinant protein construction technologies and the engineering of orthodox expression systems based on bacteria or mammalian cell cultures. However, majority of developing countries cannot afford the high costs of medicine derived from such existing methods. Hence, we need to produce not only the new drugs but also the cheaper versions of those already present in the market. Plant molecular farming is considered as a cost-effective technology that has grown and advanced tremendously over the past two decades. This book summarizes the advances and challenges of plant molecular farming for all those who are working on or have an interest in this rapidly emerging area of research.
    Type of Medium: Online Resource
    Pages: IX, 77 p. 10 illus., 9 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031127946
    Series Statement: SpringerBriefs in Plant Science,
    DDC: 580
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food science. ; Chemistry, Organic. ; Food Science. ; Organic Chemistry.
    Description / Table of Contents: Mass and Energy Balances -- Elements of fluid flow -- Elements of Heat transfer -- Elements of Mass transfer -- Reaction kinetics -- Phase and Reaction Equilibrium, and phase transitions -- Thermal processing of foods -- Environmental issues in food engineering -- An engineering view of the fate of food in the Gastrointestinal tract (GIT) -- A selection of engineering methodologies for food product realization -- Index.
    Abstract: As an introductory text book on food engineering principles, this text gives students a firm, quantitative foundation in all aspects of food process and product formulation, packaging, manufacturing processes; engineering aspects of the fate of food in the GI tract; engineering principles of the environmental impact of foods; and principles of process economics and project management. The contents are based on a new definition of Food Engineering which is fit-for-purpose for this day and age: Food Engineering is the work of designing, formulating and manipulating food products which have desired sensory, satiety, health and well-being responses; and developing - across various operational scales - designs for the lowest environmental impact processing, packaging and storage systems capable of realizing the products. Based on this definition, Engineering Principles for Food Process and Product Realization re-defines the core competencies of food engineering, covers the engineering principles needed for food process and product design, and examines the engineering principles relevant to the interactions between food on the one hand, and human health, security and environment on the other – which are the key drivers for the growth of food business. With security, human health and environmental legacy driving business, the engineering paradigm must shift from being farm and preservation focused to becoming consumer focused - which this book aims to achieve. All of these topics are covered at a level that is easy to read and absorb, but with challenging questions and problems which require knowledge integration across topics. This book is uniquely placed to serve as an effective launching pad for undertaking further studies on advanced topics and concepts relating to the design of food processes and products.
    Type of Medium: Online Resource
    Pages: XI, 249 p. 90 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031075704
    Series Statement: Food Engineering Series,
    DDC: 641.3
    Language: English
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  • 15
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neuropharmacology. ; Psychiatry. ; Neurology . ; Neuropharmacology. ; Psychiatry. ; Neurology.
    Description / Table of Contents: Dosing psychedelics and MDMA -- Psychedelic Group Therapy -- Set and Setting: Aesthetic experiences and their contribution to psychedelic therapies -- Psychedelic-Assisted Therapy for Social Adaptability in Autistic Adults -- Foundations for Training Psychedelic Therapists -- Ayahuasca for the Treatment of Depression -- Psilocybin for the Treatment of Depression -- Ketamine for the Treatment of Depression -- The Potential of Psychedelics for End of Life and Palliative Care -- Psychedelic-Assisted Therapy for Addiction and Potential Mechanisms of Action -- Psilocybin for Tobacco Use Disorder -- Psychedelic Drugs as Anti-Inflammatory Agents -- Psilocybin for the Treatment of Obsessive-Compulsive Disorder -- Psilocybin for the Treatment of Headache and Pain Disorders -- Psilocybin for the Treatment of Neurodegenerative Disorders -- Psilocybin for Trauma-Related Disorders.
    Abstract: Psychedelic therapies are gaining traction as potential treatments for a wide range of indications, but the structure and delivery of psychedelic therapies are a sharp departure from more traditional models of psychotherapy and pharmacotherapy for psychiatric and other medical disorders. This may be critical to their success. The current volume provides a comprehensive review of the state of the science of psychedelic therapies, including discussion of models and approaches to psychedelic therapies as well as the current status of safety and efficacy data for mood, substance use, trauma, obsessive-compulsive, neurodevelopmental, neurodegenerative disorders, neurological, and inflammatory disorders.
    Type of Medium: Online Resource
    Pages: VIII, 332 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031121845
    Series Statement: Current Topics in Behavioral Neurosciences, 56
    DDC: 615.78
    Language: English
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  • 16
    Keywords: Neurosciences. ; Biomedical engineering. ; Nanotechnology. ; Biophysics. ; Imaging systems in biology. ; Neuroscience. ; Biomedical Engineering and Bioengineering. ; Nanoengineering. ; Bioanalysis and Bioimaging. ; Biological Imaging.
    Description / Table of Contents: Part 1 -- Optically-Pumped Magnetometers Compatible with Large Transient Magnetic Fields -- Small animal biomagnetism applications -- Supine OPM-MEG in Multi-layer Cylindrical Shield -- Ambulatory MEG Arrays -- Part 2 -- "Tri-axial helium-4 optically-pumped -- magnetometers for MEG" -- Person-Sized Magnetoencephalography Systems with Optically Pumped Magnetometers -- On-scalp MEG with High-Tc SQUIDs -- "Fiber Coupled OPM in Purely Coil -- Shielded Environment" -- SERF-OPM usability for MEG in two-layer shielded rooms -- Turning OPM-MEG into a Wearable Technology -- Part 3 -- OPM Gradiometer for Magnetorelaxometry -- Unshielded High Bandwidth Magnetorelaxometry of Magnetic Nanoparticles with Optically Pumped Magnetometers -- Adult Magnetocardiography: Principles and Clinical Practice -- Fetal Magnetocardiography with OPMs -- Emerging MR sensors for biomagnetic measurements -- Index.
    Abstract: This contributed volume reviews the latest advances in all the new technologies currently developed for MagnetoEncephaloGraphy (MEG) recordings, as well as sensor technologies and integrated sensor arrays for on-scalp MEG. The book gives an account of the first MEG imaging studies and explores the new field of feasible, experimental paradigms of on-scalp MEG. This is an ideal book for engineers, researchers, and students in the neurosciences interested in MEG imaging. .
    Type of Medium: Online Resource
    Pages: IX, 315 p. 104 illus., 88 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031053634
    DDC: 612.8
    Language: English
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  • 17
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Post-translational modification. ; Bioinformatics. ; Molecular biology. ; Nervous system Diseases. ; Post-translational Modifications. ; Computational and Systems Biology. ; Molecular Biology. ; Neurological Disorders.
    Description / Table of Contents: Protein extraction and sample preparation methods for shotgun proteomics with central nervous system cells and brain tissue -- Phosphopeptide enrichment techniques: a pivotal step for phosphoproteomic studies -- Post-Translational Modifications during Brain Development -- Aberrant protein glycosylation in brain cancers, with emphasis on glioblastoma -- Post-Translational Modification in Muscular Dystrophies -- Post-translational Modifications in Parkinson’s Disease -- Histone Modifications in Neurological Disorders -- Mitochondrial dysregulation and the influence in neurodegenerative diseases -- PTMs: A missing piece for schizophrenia studies -- Post-Translational Modifications in Brain Diseases: A Future for Biomarkers -- Index.
    Abstract: This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs. .
    Type of Medium: Online Resource
    Pages: VIII, 146 p. 13 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031054600
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1382
    DDC: 572.645
    Language: English
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  • 18
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Invertebrates. ; Freshwater ecology. ; Marine ecology. ; Invertebrate Zoology. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Identification Key: Freshwater Invertebrates -- Sponges: Porifera -- Cnidarians: Cnidaria -- Flatworms: Platyhelminthes -- Hairybacks: Gastrotricha; Water Bears: Tardigrada -- Rotifers: Rotifera -- Horsehair Worms: Nematomorpha; Roundworms: Nematoda -- Snails, Limpets and Mussels: Mollusca -- Segmented Worms: Annelida -- Aquatic Spiders and Mites: Chelicerata -- Crustaceans: Crustacea -- Springtails: Collembola -- Mayflies: Ephemeroptera -- Dragonflies and Damselflies: Odonata -- Stoneflies: Plecoptera -- Water Bugs: Heteroptera -- Beetles: Coleoptera -- Sialidae, Osmylidae, Sisyridae -- Caddisflies: Trichoptera -- Moths: Lepidoptera -- True Flies: Diptera -- Moss Animals: Bryozoa.
    Abstract: This up-to-date guidebook on freshwater invertebrates of the central European region is a richly illustrated work, providing an excellent source of systematic information on freshwater macroinvertebrates. Numerous colour photos and additional vector graphic figures allow readers to identify specific species at a higher taxonomic level (family). The book is supplemented by video sequences. Freshwater Invertebrates in Central Europe – A Field Guide is a must-have for all those interested in the freshwater animals of central Europe such as animal scientists and ecologists, as well as students attending classes on freshwater invertebrate.
    Type of Medium: Online Resource
    Pages: X, 527 p. 525 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030953232
    DDC: 592
    Language: English
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  • 19
    Keywords: Evolution (Biology). ; Environment. ; History. ; Conservation biology. ; Ecology . ; Ethics. ; Environmental sciences Social aspects. ; Evolutionary Biology. ; Environmental Sciences. ; History. ; Conservation Biology. ; Moral Philosophy and Applied Ethics. ; Environmental Social Sciences.
    Description / Table of Contents: Part I. Biology and Culture -- Chapter 1. Speciesism in Biology and Culture: How Human Exceptionalism is Pushing Planetary Boundaries -- Chapter 2. Race and Human Genomic Variation -- Chapter 3. Science Without Species: Doing Science With Tree-Thinking -- Part II. Culture and History -- Chapter 4. The Colonization of Islands as Microcosms for Human Impacts on an Interplanetary Scale -- Chapter 5. Species, God, and Dominion -- Chapter 6. Symbols and How We Came to be Human -- Part III. Conservation and Law -- Chapter 7. Law and Nature: Human, Nonhuman, and Ecosystem Rights -- Chapter 8. A Phylogenetic Approach to Conservation: Biodiversity and Ecosystem Functioning for a Changing Globe -- Part IV. Sustainability and the Future -- Chapter 9. Energy and Society: Toward a Sustainable Future.
    Abstract: This open access book explores a wide-ranging discussion about the sociopolitical, cultural, and scientific ramifications of speciesism and world views that derive from it. In this light, it integrates subjects across the natural sciences, social sciences, and humanities. The 21st-century western world is anthropocentric to an extreme; we adopt unreasonably self-centered and self-serving ideas and lifestyles. Americans consume more energy resources per person than most other nations on Earth and have little concept of how human ecology and population biology interface with global sustainability. We draw upon religion, popular culture, politics, and technology to justify our views and actions, yet remain self-centered because our considerations rarely extend beyond our immediate interests. Stepping upward on the hierarchy from “racism,” “speciesism” likewise refers to the view that unique natural kinds (species) exist and are an important structural element of biodiversity. This ideology manifests in the cultural idea that humans are distinct from and intrinsically superior to other forms of life. It further carries a plurality of implications for how we perceive ourselves in relation to nature, how we view Judeo-Christian religions and their tenets, how we respond to scientific data about social problems such as climate change, and how willing we are to change our actions in the face of evidence. .
    Type of Medium: Online Resource
    Pages: XVI, 203 p. 28 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030990312
    DDC: 576.8
    Language: English
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  • 20
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Biodiversity. ; Animal migration. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Biodiversity. ; Animal Migration.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. European pearl mussel: background information and literature review -- Chapter 3. Materials and methods -- Chapter 4. Results -- Chapter 5. Discussion -- Chapter 6. Conclusions.
    Abstract: The monograph focuses on the European freshwater pearl mussel Margaritifera margaritifera, which is an endangered bivalve species. Most of its populations in the Russian section of the Baltic Sea basin had never been studied, although they were known in the past to the pearl fishers. “Rediscovery” included search for the previously unknown populations, revealing the facts of population extinctions, analysis of negative impacts, elaboration of conservation measures, and revealing of regularities in distribution. Patterns of land use and river management were analyzed. The procedure of “rediscovery” was applied for other animal species of Northwest Russia, which are threatened on a global scale – thick-shelled mussel, Unio crassus; curlew Numenius arquata; black-tailed godwit, Limosa limosa; Northern Lapwing, Vanellus vanellus; European mink, Mustela lutreola; pond bat, Myotis dasycneme; Atlantic sturgeon, Acipenser sturio; and broad-clawed crayfish, Astacus astacus. The methods and principles of conservation studies were discussed. The obtained data were analyzed with respect to current global change of biosphere. The book will appeal to specialists dealing with conservation studies and activities such as red lists, river protection, and conservation of endangered species. Moreover, a part of the book represents an interest for biogerontology as it presents discredit of the popular concept on “negligible senescence.” The data on distribution of some animals in Russia will be interesting in terms of zoology and biogeography, as they are not yet sufficiently represented in the international editions. The book can be used as supplemental reading for courses in biological invasions, ecology and conservation, and biodiversity. The work also contains chapters on global processes (deforestation, desertification, river degradation) and can therefore also be used for general courses in environmental sciences.
    Type of Medium: Online Resource
    Pages: XI, 246 p. 88 illus., 87 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030662554
    DDC: 577.6
    Language: English
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  • 21
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant biotechnology. ; Plant genetics. ; Agriculture. ; Plant Biotechnology. ; Plant Genetics. ; Agriculture.
    Description / Table of Contents: Economic/Academic importance -- Background of the sequencing initiatives -- Molecular mapping and cloning of genes and QTLs -- Physical mapping of the genome -- Whole genome sequencing and assembling -- Structure and composition of centromere in Brassica genome -- Genome annotation -- Gene loss -- Alternative splicing -- Gene conversion -- Gene family differentiation in Brassica species -- Glucosinates -- R genes variations after triplication -- Structural & functional genomic resources developed -- Impact on plant breeding and crop improvement -- Data bases -- Future prospects.
    Abstract: This book presents comprehensive information on genetics, genomics and breeding in Brassica oleracea, an agriculturally important species that includes popular vegetable crops such as cabbage, cauliflower, broccoli, Brussels sprouts, kale, collard greens, savoy, kohlrabi, and gai lan. The content spans whole genome sequencing, assembly and gene annotation for this global vegetable species, along with molecular mapping and cloning of genes, physical genome mapping and analyses of the structure and composition of centromeres in the B. oleracea genome. The book also elaborates on asymmetrical genome evolution and transposable elements in the B. oleracea describes gene family differentiation in comparison to other Brassica species and structural and functional genomic resources and data bases developed for B. oleracea. Useful discussions on the impact of genome sequencing on genetic improvement in the species are also included.
    Type of Medium: Online Resource
    Pages: XXIV, 145 p. 33 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030310059
    Series Statement: Compendium of Plant Genomes,
    DDC: 631.52
    Language: English
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  • 22
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Hematology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Hematology.
    Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.
    Abstract: It has been 10 years since the first edition of ‘Essentials of Tissue Banking’ has been published. There is still relatively little published on the technical and scientific principles on routine tissue and cell banking based on scientific principles. The 1st edition was very successful and, after a 10 year gap, there is a need of an update and an expansion of the book’s remit. The format of the book follows that of the previous edition- split into 5 sections. Management of donors and the banking of common tissues and cells; Principles of storage and processing of tissues and cells; Ensuring the safety of the products by testing the donor, the tissues and the environment, supported by a quality system and an IT infrastructure- all working within the constraints of current regulatory and ethical environments. This edition however provides a significant update. Many the chapters have been completely rewritten by different experts. Like the 1st edition, they were given a free hand in the way they wrote their chapter, with a guideline that they had to be concise, clear and up to date. The authors were also asked to provide the scientific and technical basis that provides the rationale of the processes they describe. Also, the scope of the book has been somewhat extended. In view of the fact that many cellular therapies are now routinely practiced, 2 new chapters have been added: one on the banking of haematopoietic stem cells and one on human embryonic stem cells. They have been deliberately chosen to illustrate the extreme spectrum of cellular therapies from one of the simplest to one of the most complex. The intention of the book has remained the same: to cover and update banking of current practices in essential tissue and cell banking. It is therefore hoped that by keeping the book as concise and up to date as possible, it will find a place on the shelves of many tissue establishments.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 48 illus., 28 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030716219
    DDC: 610.72
    Language: English
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  • 23
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical microbiology. ; Pharmacology. ; Pediatrics. ; Medical Microbiology. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Part 1 General Vaccinology -- 1 Expected and Unexpected Effects of Vaccination -- 2 How Vaccinating People Can Also Protect Others -- 3 Childhood and Adolescent Immunization Programs in Europe -- 4 Vaccine Hesitancy, Acceptance, and Demand -- 5 Adjuvants in Pediatric Vaccines -- 6 Maternal Immunization -- 7 Neonatal Immunization -- Part 2 Viral Vaccines and Vaccinations -- 8 Poliovirus Vaccines -- 9 Measles–Mumps–Rubella Vaccine -- 10 Varicella Vaccines -- 11 Rotavirus Vaccine -- 12 Hepatitis A Vaccines -- 13 Hepatitis B Vaccines -- 14 Influenza Vaccines -- 15 Human Papillomavirus Vaccines -- 16 Tick-Borne Encephalitis Vaccines -- Part 3 Bacterial Vaccines and Vaccination -- 17 Tuberculosis Vaccines -- 18 Pertussis Vaccines -- 19 Haemophilus influenzae type b (Hib) Vaccines -- 20 Pediatric Combination Vaccines -- 21 Pneumococcal Vaccines -- 22 Meningococcal Vaccines -- 23 Pediatric Vaccines for Travel Outside Europe -- Part 4 New Vaccines in Pipeline Development -- 24 GBS and CMV Vaccines in Pipeline Development -- 25 Norovirus Vaccines in Pipeline Development -- 26 RSV Vaccines and Monoclonal Antibodies in Development -- 27 COVID-19 in Children and COVID-19 Vaccines -- 28 Registration of Vaccines, Safety Follow-Up, and Pediatric Investigation Plan.
    Abstract: This second fully updated and extended edition of the textbook serves as a highly readable guide on latest developments in vaccine development and vaccination programs in infants, children and adolescents from a European perspective. The first part of the book introduces to general vaccinology, immunization programs and formulation, effects and unwanted effects of vaccines. The second and third part provide an overview on current viral and bacterial vaccines. The fourth and last part of this book discusses new vaccines in the pipeline and gives insights into safety and regulatory matters. This second edition is extended by a whole new chapter on COVID-19 vaccines. This book serves as a reference textbook in the field and helps to standardize the information on vaccines and immunization programs in the WHO European Region.
    Type of Medium: Online Resource
    Pages: XIII, 319 p. 66 illus., 63 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030771737
    DDC: 616.9041
    Language: English
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  • 24
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biophysics. ; Cell interaction. ; Biomedical engineering. ; Cardiovascular system. ; Physiology. ; Cardiography. ; Molecular biology. ; Clinical biochemistry. ; Mechanobiological Cell Signaling. ; Biomedical Engineering and Bioengineering. ; Cardiovascular Physiology. ; Cardiography. ; Molecular Biology. ; Medical Biochemistry.
    Description / Table of Contents: Part 1: Cardiac Signaling -- Chapter 1: Calcium-Dependent Signaling in Cardiac Myocytes -- Chapter 2: Organization of Ca2+ Signaling Microdomains in Cardiac Myocytes -- Chapter 3: Stress Kinase Signaling in Cardiac Myocytes -- Chapter 4: Cardiotoxicity and cardiac cell signaling -- Chapter 5: Protein Phosphatase Signaling in Cardiac Myocytes -- Chapter 6: Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function -- Chapter 7: NADPH Oxidase System Mediates Cholesterol Secoaldehyde-Induced Oxidative Stress and Cytotoxicity in H9c2 Cardiomyocytes -- Chapter 8: Lipid Mediators in Cardiovascular Physiology and Disease -- Chapter 9: Cardiac Inflammasome and Arrhythmia -- Chapter 10: Myocardial Fibrosis: Cell Signaling and In Vitro Modeling -- Chapter 11: Neural regulation of cardiac rhythm -- Part 2: Vascular Signaling -- Chapter 12: Mechanisms of lipoproteins and reverse cholesterol transport in atherosclerotic cardiovascular disease -- Chapter 13: Atherosclerotic plaque regression: Future perspective -- Chapter 14: Role of Bioactive Lipid, Phosphatidic Acid in Hypercholesterolemia Drug-induced Myotoxicity – Statin-induced Phospholipase D (PLD) Lipid Signaling in Skeletal Muscle Cells -- Chapter 15: Cell-Cell Communication in the Vascular Endothelium -- Chapter 16: Lysophosphatidic acid regulates endothelial barrier integrity -- Chapter 17: Regulation of Vascular Endothelial Barrier Integrity and Function by Lipid-Derived Mediators -- Chapter 18: Hyperglycemic Oxoaldehyde (Glyoxal)-induced Vascular Endothelial Cell Damage through Oxidative Stress is protected by Thiol Iron Chelator, Dimercaptosuccinic Acid – Role of Iron in Diabetic Vascular Endothelial Dysfunction.
    Abstract: This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases. This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.
    Type of Medium: Online Resource
    Pages: XVIII, 527 p. 83 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031083099
    DDC: 571.4
    Language: English
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  • 25
    Keywords: Agriculture. ; Botany. ; Agriculture. ; Plant Science.
    Description / Table of Contents: Preface -- Part I: Leaves -- Chapter 1. Advances in Chicory (Cichorium intybus L.) Breeding Strategies (Laila Aldahak, Khaled F. M. Salem, Salih H. F. Al-Salim, and Jameel M. Al-Khayri) -- Chapter 2. Chinese Cabbage (Brassica rapa L. var. pekinensis) Breeding: Application of Molecular Technology (Takumi Okamoto, Xiaochun Wei, Hasan Mehraj, Mohammad Rashed Hossain, Ayasha Akter, Naomi Miyaji, Yoshinobu Takada, Jong-In Park, Ryo Fujimoto, Ill-Sup Nou, and Masao Watanabe) -- Chapter 3. Breeding Advances and Prospects in Rocket Salad (Eruca vesicaria ssp. sativa Mill.) Cultivation (Pasquale Tripodi, Paula Santos Coelho, and Carla Guijarro-Real) -- Chapter 4. Spring Onion (Allium fistulosum L.) Breeding Strategies (Fatimah Kayat, Ahmed Mahmood Ibrahim, and Arifullah Mohammed) -- Chapter 5. Water Spinach (Ipomoea aquatica Forsk.) Breeding (Moumita Gangopadhyay, Anup Kumar Das, Subhendu Bandyopadyay, and Samanwita Das) -- Chapter 6. Watercress (Nasturtium officinale R. Br.) Breeding (Mohammadreza Hassandokht, Sajad Jafari, and Raheleh Ebrahimi) -- Part II: Flowerheads and Green Pods -- Chapter 7. Advances in Cauliflower (Brassica oleracea var. botrytis L.) Breeding, with Emphasis on India (Pritam Kalia and Shrawan Singh) -- Chapter 8. Globe Artichoke (Cynara cardunculus var. scolymus L.) Breeding (Fernando López-Anido and Eugenia Martin) -- Chapter 9. Breeding Strategies of Garden Pea (Pisum sativum L.) (Amal M.E. Abdel Hamid and Khaled F.M. Salem) -- Chapter 10. Genetic Improvement of Yardlong Bean (Vigna unguiculata (L.) Walp. ssp. sesquipedalis (L.) Verdc.) (Pidigam Saidaiah, Thuraga Vishnukiran, Someswar Rao Pandravada, Natarajan Sivaraj, Adimulam Srivani, Amarapalli Geetha, Nimmarajula Srinivas, and Venkateswaran Kamala) -- Part III: Mushrooms -- Chapter 11. Enoki Mushroom (Flammulina velutipes (Curtis) Singer) Breeding (Ved P. Sharma, Anupam Barh, Rakesh Kumar Bairwa, Sudheer K. Annepu, Babita Kumari and Shwet Kamal) -- Chapter 12. Shiitake Mushroom (Lentinula edodes (Berk.) Sing.) Breeding in China (Quanju Xiang, Bilal Adil, Qiang Chen, Yunfu Gu, Xianfu Zeng, and Xinzhu Li) -- Part IV: Truffles -- Chapter 13. Desert Truffles (Terfezia spp.) Breeding (Asunción Morte, Francisco Arenas, José E. Marqués-Gálvez, Alberto Andrino, Ángel L. Guarnizo, Almudena Gutiérrez, Luis Miguel Berná, Manuela Pérez-Gilabert, Antonio Rodríguez, and Alfonso Navarro-Ródenas) -- Chapter 14. Enhancing White Truffle (Tuber magnatum Picco and T. borchii Vittad.) Cultivation through Biotechnology Innovation (Alessandra Zambonelli, Mirco Iotti, Federico Puliga, and Ian R. Hall).
    Abstract: Plant breeders and geneticists are under constant pressure to sustain and expand food production by using innovative breeding strategies and introducing minor crops, which are well adapted to marginal lands, provide a source of nutrition, and have abiotic and biotic stress tolerance, to feed an ever-increasing human population. The basic concept of this book is to examine the use of innovative methods, augmenting traditional plant breeding, towards the improvement and development of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. Three volumes of the book series Advances in Plant Breeding Strategies were published in 2015, 2016 and 2018, respectively: Volume 1. Breeding, Biotechnology and Molecular Tools; Volume 2. Agronomic, Abiotic and Biotic Stress Traits and Volume 3. Fruits. In 2019, the following four volumes were published: Volume 4. Nut and Beverage Crops, Volume 5. Cereals, Volume 6. Industrial and Food Crops and Volume 7. Legumes. Recent volumes published in 2021 include: Volume 8. Vegetable Crops: Bulbs, Roots and Tubers, Volume 9. Vegetable Crops: Fruits and Young Shoots and Volume 10. Vegetable Crops: Leaves, Flowerheads, Green Pods, Mushrooms and Truffles. This Volume 10, subtitled Vegetable Crops: Leaves, Flowerheads, Green Pods, Mushrooms and Truffles, consists of 14 chapters focusing on advances in breeding strategies using both traditional and modern approaches for the improvement of individual vegetable crops. Chapters are arranged in 4 parts according to the edible vegetable parts. Part I: Leaves - Chicory, Chinese cabbage, Rocket salad, Spring onion, Water spinach and Watercress; Pat II: Flowerheads and Green Pods - Cauliflower, Globe artichoke, Garden pea and Yardlong bean; Part III: Mushrooms - Enoki mushroom and Shiitake mushroom; Part IV: Truffles - Desert truffles and White truffle. Each chapter comprehensively reviews the contemporary literature on the subject and reflects the experiences of the authors. Chapters are written by internationally-reputable scientists and subjected to a review process to assure quality presentation and scientific accuracy. Each chapter begins with an introduction covering related backgrounds and provides in-depth discussion of the subject supported with high-quality color photos, illustrations and relevant data. The chapter concludes with recommendations for future research directions, a comprehensive list of pertinent references to facilitate further reading, and appendixes of genetic resources and concerned research institutes. This book series is a valuable resource for advanced students, researchers, scientists, commercial producers and seed companies as well as consultants and policymakers interested in agriculture, particularly in modern breeding technologies.
    Type of Medium: Online Resource
    Pages: XVII, 540 p. 98 illus., 76 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030669690
    DDC: 630
    Language: English
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  • 26
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Bioinformatics. ; Imaging systems in biology. ; Cell Biology. ; Computational and Systems Biology. ; Biological Imaging.
    Description / Table of Contents: Introduction -- Batch Processing Methods in ImageJ -- Python: Data Handling, Analysis and Plotting -- Building a Bioimage Analysis Workflow Using Deep Learning -- GPU-Accelerating ImageJ Macro Image Processing Workflows Using CLIJ -- How to Do the Deconstruction of Bioimage Analysis Workflows: A Case Study with SurfCut -- i.2.i. with the (Fruit) Fly: Quantifying Position Effect Variegation in Drosophila Melanogaster -- A MATLAB Pipeline for Spatiotemporal Quantification of Monolayer Cell Migration.
    Abstract: This open access textbook aims at providing detailed explanations on how to design and construct image analysis workflows to successfully conduct bioimage analysis. Addressing the main challenges in image data analysis, where acquisition by powerful imaging devices results in very large amounts of collected image data, the book discusses techniques relying on batch and GPU programming, as well as on powerful deep learning-based algorithms. In addition, downstream data processing techniques are introduced, such as Python libraries for data organization, plotting, and visualizations. Finally, by studying the way individual unique ideas are implemented in the workflows, readers are carefully guided through how the parameters driving biological systems are revealed by analyzing image data. These studies include segmentation of plant tissue epidermis, analysis of the spatial pattern of the eye development in fruit flies, and the analysis of collective cell migration dynamics. The presented content extends the Bioimage Data Analysis Workflows textbook (Miura, Sladoje, 2020), published in this same series, with new contributions and advanced material, while preserving the well-appreciated pedagogical approach adopted and promoted during the training schools for bioimage analysis organized within NEUBIAS – the Network of European Bioimage Analysts. This textbook is intended for advanced students in various fields of the life sciences and biomedicine, as well as staff scientists and faculty members who conduct regular quantitative analyses of microscopy images.
    Type of Medium: Online Resource
    Pages: X, 212 p. 265 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030763947
    Series Statement: Learning Materials in Biosciences,
    DDC: 571.6
    Language: English
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  • 27
    Keywords: Plant anatomy. ; Stress (Physiology). ; Plants. ; Plant physiology. ; Plant ecology. ; Plants Development. ; Agriculture. ; Plant Anatomy and Morphology. ; Plant Stress Responses. ; Plant Physiology. ; Plant Ecology. ; Plant Development. ; Agriculture.
    Description / Table of Contents: Crosstalk between autophagy and hormones for abiotic stress tolerance in plants -- Abscisic acid and plant response under adverse environmental conditions -- Auxins and plant response to adverse environmental conditions -- Jasmonic acid for sustainable plant growth and production under adverse environmental conditions -- Salicylic acid for vigorous plant growth and enhanced yield under harsh environment -- Strigolactones for sustainable plant growth and production under adverse environmental conditions -- Polyamines for sustainable plant growth and production under adverse environmental conditions -- Plant performance and defensive role of proline under environmental stress -- Plant performance and defensive role of β-amino butyric acid under environmental stress -- Plant performance and defensive role of γ-gamma amino butyric acid under environmental stress -- Nitric oxide: A key modulator of plant responses under environmental stress -- Functions of hydrogen sulfide in plant regulation and response to abiotic stress -- Silicon and plant responses under adverse environmental conditions -- Nanofertilizers as tools for plant nutrition and plant biostimulation under adverse environment -- Biostimulants and plant response under adverse environmental conditions: a functional interplay -- Biofertilizers-mediated sustainable plant growth and production under adverse environmental conditions -- Seed priming: A cost-effective strategy to impart abiotic stress tolerance -- Significance of cyanobacteria in soil-plant system and for ecological resilience -- Phytomicrobiome community: An agrarian perspective -- Adverse environment and pest management for sustainable plant production -- Eco-friendly approaches of using weeds for sustainable plant growth and production.
    Abstract: Global climate change is bound to create a number of abiotic and biotic stresses in the environment, which would affect the overall growth and productivity of plants. Like other living beings, plants have the ability to protect themselves by evolving various mechanisms against stresses, despite being sessile in nature. They manage to withstand extremes of temperature, drought, flooding, salinity, heavy metals, atmospheric pollution, toxic chemicals and a variety of living organisms, especially viruses, bacteria, fungi, nematodes, insects and arachnids and weeds. Incidence of abiotic stresses may alter the plant-pest interactions by enhancing susceptibility of plants to pathogenic organisms. These interactions often change plant response to abiotic stresses. Plant growth regulators modulate plant responses to biotic and abiotic stresses, and regulate their growth and developmental cascades. A number of physiological and molecular processes that act together in a complex regulatory network, further manage these responses. Crosstalk between autophagy and hormones also occurs to develop tolerance in plants towards multiple abiotic stresses. Similarly, biostimulants, in combination with correct agronomic practices, have shown beneficial effects on plant metabolism due to the hormonal activity that stimulates different metabolic pathways. At the same time, they reduce the use of agrochemicals and impart tolerance to biotic and abiotic stress. Further, the use of bio- and nano-fertilizers seem to hold promise to improve the nutrient use efficiency and hence the plant yield under stressful environments. It has also been shown that the seed priming agents impart stress tolerance. Additionally, tolerance or resistance to stress may also be induced by using specific chemical compounds such as polyamines, proline, glycine betaine, hydrogen sulfide, silicon, β-aminobutyric acid, γ-aminobutyric acid and so on. This book discusses the advances in plant performance under stressful conditions. It should be very useful to graduate students, researchers, and scientists in the fields of botanical science, crop science, agriculture, horticulture, ecological and environmental science.
    Type of Medium: Online Resource
    Pages: XIV, 606 p. 54 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030785215
    DDC: 571.32
    Language: English
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  • 28
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food science. ; Food Analysis. ; Chemistry. ; Sustainability. ; Food Engineering. ; Food Science. ; Food Chemistry. ; Sustainability.
    Description / Table of Contents: Part I: Introduction -- 1.Sustainability in food science and food industry: where are we now? – Viewpoints of the EFFoST Working Group on Sustainable Food Systems -- 2. Innovative processing: from raw material (culture), harvesting, post harvesting, processing, and applications -- Part II: Mechanism of action of nonthermal processing technologies (NTP) -- 3. Fundamental mechanisms of action -- 4. Electro-technologies: pulsed electric fields, cold plasma, radio-frequency and oscillating magnetic fields, electrohydrodynamic processing, electron beam processing and ionizing radiation -- 5. Pressure-based technologies: high pressure processing; supercritical and subcritical fluid processing -- 6. Mechanical technologies: ultrasound, and hydrodynamic cavitation -- 7. Non-electro-technologies: gamma rays, UV light, pulsed light, ozonation, photodynamic and membrane processing -- 8. Non-electro-technologies: gamma rays, UV light, ozone, photodynamic and membrane processing -- Part 3: Implementation of novel nonthermal technologies in agri-food-bio sciences -- 9. Nonthermal Processing Technologies: Synergies and new applications in food engineering -- 10. Implementation of novel nonthermal plasma air cleaner in a plant factory -- 11. LED-based photosensitization – a prospect for visible light-driven nonthermal fresh produce sanitation -- 12. Electrospinning Technology: Its Process Conditions and Food Packaging Applications -- 13. Application of encapsulation technology in the agri-food sector -- Part 4. Nonthermal processing legislation -- 14. Overview of legislation across the globe, diagnostics and standards which provide a legal and regulatory framework in which NTP is used worldwide -- 15. Current technology readiness levels (TRL) of nonthermal technologies and research gaps for improved process control and integration into existing production lines -- 16. Industry implementation (scale-up): Clients’ experience towards understanding of how regulations are affecting novel product development -- 17. Supercritical fluids as a tool for sustainable manufacturing of added value products -- Part 5 Mechanisms of validation of nonthermal processes in biomaterials and agri-food applications -- 18. Current validation of NTP technologies and overview of their current and potential implementation in the production chain including agri-food wastes -- Part 6. Sustainable perspective of nonthermal technologies -- 19. New product development from marine sources and side streams valorization using nonthermal processing technologies -- 20. Efficient production of functional and bioactive compounds and foods for use in food, pharma, cosmetic and other industries -- 21. Decontamination of fruit juices by combination of high intensity pulsed light and other nonthermal technologies -- 22. Food-On-A-Chip: Relevance of Microfluidics in food processing -- Part 7. Food waste management and sustainable parameters analysis -- 21. Analysis and comparison of environmental impacts of nonthermal food technologies -- 22. Emerging non-thermal processing of food waste and by-products for sustainable food systems - selected cases -- 23. Strategies for commercializing scientific results and combining separate processes into complex technologies -- 24 Sustainable processing through efficient use of energy and minimizing waste production -- 25. Food Safety and Security (HACCP and HAZOP) for Consumers and Workers (Nonthermal Technologies and their use) -- Part 8. Success stories of industrial implementation of nonthermal technologies -- 26.: Innovative success stories on commercial non-thermal technologies - interviews of major food industries working in this area. .
    Abstract: This book addresses important questions on the legislation, regulations, sustainability, technology transfer, safety of biomaterials and mechanism of action of nonthermal processing on the molecular level of biomaterials and its impact on health. The chapters take an interdisciplinary approach that is of interest to specialists from engineering, physics, chemistry, agriculture, life sciences and beyond, with a focus on further development of existing and new applications of nonthermal processing and their combination with other methods in the processing of biomaterials, agriculture, biotechnology and the re-use of waste and by-products. Nonthermal Processing in Agri-Food-Bio Sciences: Sustainability and Future Goals aims to boost further developments and applications of nonthermal technologies to develop healthier products, to ensure consumer approval for these innovative technologies and to improve the sustainability of biomaterials production. The industrial application of nonthermal processing has led to an increase in innovative value products and the overall improvement of production capacity. Nonthermal processes use less energy and chemicals, reduce processing times, have less environmental impact, produce less waste and have the potential for industrial scale-up and a return-on-investment in under 5 years. According to The United Nations and the 2030 Agenda for Sustainable Development, 17 goals should be incorporated within development projects, and researchers are starting to use novel techniques to meet them. In covering the fundamental engineering theories underlying nonthermal processing, this book will aid in this mission. The book overviews the advantages and disadvantages of novel technologies, over to sustainability goals to correct steps for the scale-up and return on investment. The book includes the chemistry and physics of nonthermal processing technologies, dedicated to specialists and researchers from a wide range of subject areas. Interdisciplinary scientists and engineers, sustainability experts can use this text to aid in their work in green technologies.
    Type of Medium: Online Resource
    Pages: VIII, 791 p. 124 illus., 74 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030924157
    Series Statement: Food Engineering Series,
    DDC: 664
    Language: English
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  • 29
    Keywords: Neurosciences. ; Animal culture. ; Veterinary medicine. ; Neuroscience. ; Animal Science. ; Veterinary Science.
    Description / Table of Contents: Rodents -- Carnivores -- Sheep and goats -- Swine -- Rabbits -- Bovines -- Non-human primates -- Humans -- Squirrels.
    Abstract: Modern neuroscience has presented new opportunities for exploring the molecular and neural mechanisms controlling specific social responses. This book reviews insights into the neural circuits underlying a particularly fascinating form of social interaction, parental behavior. This book presents a detailed review of maternal and paternal behavior of particular mammalian species. It offer neuroscientists a spectrum of specific mammals that can be used as experimental models to explore particular topics on the functions of the nervous system. It shows that results coming from the laboratory can be translated into useful information for raising mammals on the farm, and it stimulates biologists to gain insights into the underpinnings of the complex mechanisms governing mammalian behavior in the wild. It also discusses the implications of this research for human parental behavior. .
    Type of Medium: Online Resource
    Pages: V, 309 p. 45 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030977627
    Series Statement: Advances in Neurobiology, 27
    DDC: 612.8
    Language: English
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  • 30
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Biophysics. ; Cell interaction. ; Cytology. ; Cancer Microenvironment. ; Mechanobiological Cell Signaling. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 191 p. 31 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030471897
    Series Statement: Advances in Experimental Medicine and Biology, 1270
    DDC: 571.978
    Language: English
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  • 31
    Keywords: Phylogeny. ; Biology Technique. ; Gene expression. ; Bioinformatics. ; Phylogenetics. ; Gene Expression Analysis. ; Bioinformatics.
    Description / Table of Contents: Introduction to phylogenetic trees -- A divergence time story: the rise and fall of the molecular clock -- Estimating phylogenetic trees -- Estimating divergence times -- Estimating common ancestors -- Testing theories of molecular evolution -- Recommendations for further reading -- Appendix A: Intermittent point processes -- Appendix B: Poisson processes with Lévy-stable substitution rates.
    Abstract: This book serves as a brief introduction to phylogenetic trees and molecular evolution for biologists and biology students. It does so by presenting the main concepts in a variety of ways: first visually, then in a history, next in a dice game, and finally in simple equations. The content is primarily designed to introduce upper-level undergraduate and graduate students of biology to phylogenetic tree reconstruction and the underlying models of molecular evolution. A unique feature also of interest to experienced researchers is the emphasis on simple ways to quantify the uncertainty in the results more fully than is possible with standard methods.
    Type of Medium: Online Resource
    Pages: XIII, 106 p. 21 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031119583
    Series Statement: SpringerBriefs in Systems Biology,
    DDC: 576.88
    Language: English
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  • 32
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Geography. ; Environment. ; Power resources. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Regional Geography. ; Environmental Sciences. ; Natural Resource and Energy Economics.
    Description / Table of Contents: Intro: Navigating Patagonian freshwaters- and this book -- 1: Are freshwaters wetlands? -- 2: Patagonian Andean lakes and climate change -- 3: Current state and recent changes of glaciers in the Patagonian Andes (35 °S to 55°S) -- 4: Biogeographical patterns of Patagonian freshwater microbiota -- 5: Extreme freshwater ecosystems from Patagonia: The Copahue-Agrio system -- 6: Mercury in aquatic systems of North Patagonia: sources, processes and trophic transfer -- 7: Diversity patterns across aquatic communities from peat bogs -- 8: Hydrologic Systems, water uses and emerging conflicts around freshwater availability in Patagonia -- 9: Land-use effects on aquatic ecosystems: An overview of environmental impacts and tools for ecological assessment -- 10: Patagonian wetlands: vertientes, vegas, mallines,turberas and lagunas -- 11: Fish and fisheries of the Patagonian steppe -- 12: Invasive species: The case of Didymosphenia geminata in Neuquén Province -- 13: Influence of the fish introduction in lakes of the arid Patagonia -- 14: Patagonian cultural limnology: knowledge and water management in Mapuche rural communities -- 15: Political Ecology, water valoration and Water Law deliberation in the Province of Tierra del Nacional de Tierra del Fuego -- 16: Freshwater systems in protected areas in Patagonia -- 17: Amphibians and waterbirds as bridges to conserve aquatic and terrestrial habitat in Patagonia -- 18: Integrated long term conservation strategies to recover the critically endangered Hooded Grebe (Podiceps gallardoi),an endemic waterbird of Austral Patagonia -- Conclusion: Reaching out for the UNDP Sustainable Development Goals in Patagonia.
    Abstract: The Freshwaters of Patagonia adopts a socioecological approach, in which experts from across Patagonia review recent, scientifically rigorous literature and data of their own, thus synthesizing the current knowledge directly relevant to understand the present state and future trends of icefields, freshwater and wetland ecosystems in this region. The book’s organization into three parts provides a studied and comprehensive view on the patterns and processes of the various ecosystems in Patagonia, and describes the sociological aspects of freshwater ecosystems, as well as characterizes the conservation of the freshwater and wetland ecosystems, in Patagonia. The chapters offer a broad, state-of-the-art overview of the current status of glaciers, freshwater and wetland ecosystems of this region, as well as studies of both local and large scale biodiversity patterns, and study cases of extreme and naturally polluted environments.The volume concludes with the current status of Patagonian freshwaters, and discusses the scientific, legal and administrative tools aimed at their sustainable management within the framework of the UNEP Sustainable Development Goals 2030 Agenda. A broad audience of students, scientists, engineers, environmental managers, and policy makers will be interested in this volume.
    Type of Medium: Online Resource
    Pages: XI, 541 p. 104 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031100277
    Series Statement: Natural and Social Sciences of Patagonia,
    DDC: 577.6
    Language: English
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  • 33
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical genetics. ; Medicinal chemistry. ; Nanomedicine. ; Cancer Treatment. ; Medical Genetics. ; Medicinal Chemistry. ; Nanomedicine and Nanotoxicology. ; Cancer Therapy.
    Description / Table of Contents: The Democratization of RNA Therapeutics -- Supramolecular Strategies for mRNA Delivery -- In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of 21st Century: Exploitation of Peptides as Carriers for their Intracellular Delivery -- Effective Delivery of mRNA Therapeutics and Vaccines Using Lipid Nanoparticles -- Messenger RNA Therapeutics -- Formulation, Delivery and Application of mRNA Therapeutics In Respiratory Diseases -- Clinical Applications of mRNA Formulated In Lipid Nanoparticles -- Preparation of Messenger RNA Loaded Nanomedicine Applied on Tissue Engineering And Regenerative Medicine -- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics: Immune Activation By Ionizable Cationic Lipids -- Adjuvants, the Elephant in the Room for RNA Vaccines -- Addressing Skin with Modified mRNA Constructs for Novel Therapies -- mRNA-Based Cancer Immunotherapies -- From Bench to Bedside: The Journey of an mRNA Drug Candidate Into a Medicine -- Synthetic mRNA Gene Therapies for Chronic HBV Infection -- Delivery Vehicles for Self-Amplifying RNA -- Delivery Technologies of mRNA Vaccines -- Nanosystems: The Key in Formulations of mRNA for Several Pathologies -- Messenger RNA Nanoformulation For Cancer Vaccine -- Preparation of Synthetic mRNAs for In Vivo Applications – Overview and Considerations -- Messenger RNA for Prophylaxis -- Nuclear Export of mRNA with Disease Pathogenesis and Therapeutic Potentials -- Messenger RNA Therapeutics: Start of a New Era in Medicine -- mRNA Delivery Technologies for Therapeutic Applications.
    Abstract: This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics.
    Type of Medium: Online Resource
    Pages: XII, 446 p. 68 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031084157
    Series Statement: RNA Technologies, 13
    DDC: 616.042
    Language: English
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  • 34
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Oncology. ; Immunology. ; Metastasis. ; Cytology. ; Cancer Biology. ; Oncology. ; Immunology. ; Metastasis. ; Cell Biology.
    Description / Table of Contents: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.
    Abstract: This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
    Type of Medium: Online Resource
    Pages: VI, 203 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031095184
    DDC: 571.978
    Language: English
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  • 35
    Keywords: Stress (Physiology). ; Plants. ; Molecular biology. ; Agriculture. ; Biotechnology. ; Plant Stress Responses. ; Molecular Biology. ; Agriculture. ; Biotechnology. ; Plant Signalling.
    Description / Table of Contents: 1. Targeted genome editing techniques in plant defense regulation -- 2. Synthetic promoters in regulating disease gene expression -- 3. Transcription factors associated with defense response against fungal biotrophs -- 4. Transcription factors associated with defense response against fungal necrotrophs -- 5. Transcription factors associated with defense response against viruses -- 6. Role of microbial bio-agents as elicitors in plant defense regulation -- 7. Transcriptional Factors Response under Biotic Stress in Wheat -- 8. Potential Transcription Factors for Biotic Stress Tolerance in Sugarcane -- 9. Role of transcription factors in response to biotic stresses in Maize -- 10. Role of transcription factors in response to biotic stresses in Pearl millet -- 11. Role of transcription factors in response to biotic stresses in Tomato -- 12. Role of transcription factors in response to biotic stresses in potato (Solanum tuberosum L.).
    Abstract: With the erratic changes in climate, crop plants are facing many forms of biotic stresses. When plants are under stress, among several gene families, regulatory genes play a vital role in signal transduction in modulating the expression of genes underpinning several defense pathways and targeting regulatory proteins (viz, transcription factors (TFs)) can be the alternative. Transcription factors directly regulate the downstream R genes and are excellent candidates for disease resistance breeding. Till date, numerous transcription factors have been identified and characterized structurally and functionally. Of them, TF families such as WRKY, NAC, Whirly, Apetala2 (AP2), ethylene responsive elements (ERF) etc. are found to be associated with transcriptional reprogramming of plant defense response. These TFs are responsive to the pathogen’s PAMPs/DAMPs - host’s PRR protein interactions and specifically binds to the cis-elements of defense genes and regulate their expression. With this background, realizing the importance of TFs in resistance breeding, this book discusses the recent research and developments in this field for various crops.
    Type of Medium: Online Resource
    Pages: VIII, 247 p. 26 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031129902
    DDC: 581.788
    Language: English
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  • 36
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Epigenetics. ; Developmental biology. ; Evolutionary developmental biology. ; Molecular Evolution. ; Zoology. ; Evolutionary genetics. ; Epigenetics. ; Developmental Biology and Stem Cells. ; Evolutionary Developmental Biology. ; Molecular Evolution. ; Zoology. ; Evolutionary Genetics.
    Description / Table of Contents: Chapter 1. An Introduction to Epigenetics, Development, Ecology and Evolution. Chapter 2. Epigenetic Regulation: The Cross-Talk among Development, Adaptive Strategies, and Microevolutionary Change -- Chapter 3. Epigenetics and Phenotypic Plasticity in Animals -- Chapter 4. Role of Environmentally Induced Epigenetic Transgenerational Inheritance in Evolutionary Biology -- Chapter 5. Transgenerational Epigenetic Programming -- Chapter 6. Epigenetics, Evolution and Development of Birds -- Chapter 7. Epigenetics and the Extreme Stress Response -- Chapter 8. Epigenetic Adaptation to Local Ecologies as a First Step toward Gene: Culture Co-evolution.
    Abstract: Epigenetic modifications comprise heritable gene expression changes that occur without alteration of the DNA sequence and 'co-act' with genetic factors to shape development processes and evolutionary trajectories. Multicellular organisms receive different types of environmental stimuli/stresses that trigger epigenetic modifications during development. These environmentally driven mechanisms represent an underlying cause of phenotypic diversity, especially in metazoans. This book aims to present some of the latest epigenetic insights into the development of metazoans (including humans) as an intersection between their ecology and evolution.
    Type of Medium: Online Resource
    Pages: XII, 232 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031137716
    DDC: 572.865
    Language: English
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  • 37
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Genetics. ; Molecular biology. ; Cancer Biology. ; Genetics and Genomics. ; Molecular Biology.
    Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.
    Abstract: Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.
    Type of Medium: Online Resource
    Pages: XVII, 167 p. 72 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030756994
    DDC: 571.978
    Language: English
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  • 38
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Invertebrates. ; Parasitology. ; Veterinary microbiology. ; Invertebrate Zoology. ; Parasitology. ; Veterinary Microbiology.
    Description / Table of Contents: 1.Origin and evolution of Triatominae -- 2. Taxonomy -- 3. Speciation Processes in Triatominae -- 4. Chromosome structure and evolution of Triatominae: A review -- 5. Embryonic development of the kissing bug Rhodnius prolixus -- 6. Anatomy of the nervous system of triatomines -- 7. Biogenic monoamines in the control of triatomine physiology with emphasis on Rhodnius prolixus -- 8. Structure and physiology of the neuropeptidergic system of triatomines -- 9. Sensory biology of triatomines -- 10. The behaviour of kissing-bugs -- 11. Features of interaction between triatomines and vertebrates based on bug feeding parameters -- 12. Blood Digestion in Triatomine Insects -- 13. The physiology of sperm transfer and egg production in vectors of Chagas disease with particular reference to Rhodnius prolixus -- 14. The Immune System of Triatomines -- 15. Interaction of triatomines with their bacterial microbiota and trypanosomes -- 16. The ecology and natural history of wild Triatominae in the Americas -- 17. Eco-epidemiology of vector-borne transmission of Trypanosoma cruzi in domestic habitats -- 18. Chagas Disease Vector Control -- 19. Insecticide resistance in triatomines -- 20. Perspectives in triatomine biology studies: “Omics”- based approaches.
    Abstract: This book aims to present updated knowledge on various aspects of the natural history, biology, and impact of triatomines to all interested readers. Each chapter will be written by authorities in the respective field, covering topics such as behavior, neurophysiology, immunology, ecology, and evolution. The contents will consider scientific, as well as innovative perspectives, on the problems related to the role of triatomine bugs as parasite vectors affecting millions in the Latin American region.
    Type of Medium: Online Resource
    Pages: XXX, 620 p. 62 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030645489
    Series Statement: Entomology in Focus, 5
    DDC: 592
    Language: English
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  • 39
    Keywords: Nervous system Surgery. ; Neuropsychology. ; Neurology . ; Neurosurgery. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: Foreword -- Preface -- Part I: Sensorimotor and visuo-spatial functions -- 1. Motor control -- 2. Vision -- 3. FEF -- 4. Spatial cognition -- Part II: Language functions -- 5. Lexical access -- 6. Spontaneous speech -- 7. Reading -- 8. Writing -- 9. Repeating -- 10. Syntactic abilities -- 11. Verbs versus nouns naming -- 12. Verbal short-term memory -- 13. Proper names retrieval -- 14. Bilingual patients -- Part III: Higher-order functions -- 15. From verbal to non-verbal semantics -- 16. Inhibition -- 17. Set-shifting -- 18. Social cognition -- 19. Multitask mapping -- Part IV: Prospects -- 20. Creativity -- 21. Psychiatric and behavorial traits -- 22. Awake surgery in patients with poor abilities of verbal communication -- 23. Can we map inner speech? -- 24. Beyond tasks: when experience shapes intuition.
    Abstract: This book aims to give the state-of-the-art of intraoperative brain function mapping for resection of brain tumors in awake conditions, and to become a reference for acquiring the fundamental expertise necessary to select the right intraoperative task at the right time of the surgery. The chapters, all focused on a specific brain function, are divided in 4 parts: sensori-motor and visuo-spatial functions, language functions, higher-order functions, and prospects. Each chapter follows the same outline, including a brief review of the current knowledge about the networks sustaining the function in healthy subjects, the description of the intraoperative tasks designed to monitor the function, a review of the literature describing the deficits in that function after surgery, and a critical appraisal of the benefit provided by intraoperative mapping of that function.
    Type of Medium: Online Resource
    Pages: XIV, 421 p. 93 illus., 90 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030750718
    DDC: 617.48
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Artificial intelligence. ; Artificial Intelligence.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Literature Review -- Chapter 3. Data Analysis -- Chapter 4. SynTime: Token Types and Heuristic Rules -- 5. TOMN: Constituent-based Tagging Scheme -- Chapter 6. UGTO: Uncommon Words and Proper Nouns -- Chapter 7. Conclusion and Future Work.
    Abstract: This book presents a synthetic analysis about the characteristics of time expressions and named entities, and some proposed methods for leveraging these characteristics to recognize time expressions and named entities from unstructured text. For modeling these two kinds of entities, the authors propose a rule-based method that introduces an abstracted layer between the specific words and the rules, and two learning-based methods that define a new type of tagging scheme based on the constituents of the entities, different from conventional position-based tagging schemes that cause the problem of inconsistent tag assignment. The authors also find that the length-frequency of entities follows a family of power-law distributions. This finding opens a door, complementary to the rank-frequency of words, to understand our communicative system in terms of language use.
    Type of Medium: Online Resource
    Pages: XIX, 96 p. 17 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030789619
    Series Statement: Socio-Affective Computing, 10
    DDC: 006.3
    Language: English
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  • 41
    Keywords: Agriculture. ; Botany. ; Agriculture. ; Plant Science.
    Description / Table of Contents: Preface -- Part I: Bulbs -- Chapter 1. Traditional and Novel Approaches in Garlic (Allium sativum L.) Breeding (Einat Shemesh-Mayer and Rina Kamenetsky Goldstein) -- Chapter 2. Genetic Improvement of Leek (Allium ampeloprasum L.) (Fevziye Celebi-Toprak and Ali Ramazan Alan) -- Chapter 3. Shallot (Allium cepa L. Aggregatum group) Breeding (Haim D. Rabinowitch) -- Part II: Roots -- Chapter 4. Molecular Breeding Strategies of Beetroot (Beta vulgaris ssp. vulgaris var. conditiva Alefeld) (Farrag F.B. Abu-Ellail, Khaled F.M. Salem, Maysoun M. Saleh, Lina M. Alnaddaf, and Jameel M. Al-Khayri) -- Chapter 5. Carrot (Daucus carota L.) Breeding (Philipp W. Simon) -- Chapter 6. Parsnip (Pastinaca sativa L.) Breeding for the Future (Lauren H.K. Chappell and Adrian J. Dunford) -- Chapter 7. Radish (Raphanus sativus L.): Breeding for Higher Yield, Better Quality and Wider Adaptability (Binod Kumar Singh) -- Chapter 8. Sugar Beet (Beta vulgaris ssp. vulgaris L.) Improvement with Next-generation Breeding Technology (Chiara De Lucchi, Enrico Biancardi, George Skaracis, Marco De Biaggi, Ourania Pavli, Samathmika Ravi, Claudia Chiodi, Chiara Broccanello, and Piergiorgio Stevanato) -- Chapter 9. Turnip (Brassica rapa var. rapa L.) Breeding (Hesham S. Abdel-Razzak) -- Part III: Tubers -- Chapter 10. Recent Advances in Potato (Solanum tuberosum L.) Breeding (Emre Aksoy, Ufuk Demirel, Allahbakhsh Joiya, Muhammad Abu Bakar Zia, Muhammad Naeem Sattar, Faisal Saeed, Sevgi Çalışkan, and Mehmet Emin Çalışkan) -- Chapter 11. Application of Genome Editing Tools to Accelerate Potato (Solanum tuberosum L.) Breeding (Zafar Iqbal and Muhammad Naeem Sattar) -- Chapter 12. Sweet potato (Ipomoea batatas L.) Breeding (Jolien Swanckaert, Dorcus Gemenet, Noelle L. Anglin, and Wolfgang Grüneberg).
    Abstract: Plant breeders and geneticists are under constant pressure to sustain and expand food production by using innovative breeding strategies and introducing minor crops, which are well adapted to marginal lands, provide a source of nutrition, and have abiotic and biotic stress tolerance, to feed an ever-increasing human population. The basic concept of this book is to examine the use of innovative methods, augmenting traditional plant breeding, towards the improvement and development of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. Three volumes of the book series Advances in Plant Breeding Strategies were published in 2015, 2016 and 2018, respectively: Volume 1. Breeding, Biotechnology and Molecular Tools; Volume 2. Agronomic, Abiotic and Biotic Stress Traits and Volume 3. Fruits. In 2019, the following four volumes were published: Volume 4. Nut and Beverage Crops, Volume 5. Cereals, Volume 6. Industrial and Food Crops and Volume 7. Legumes. Recent volumes published in 2021 include: Volume 8. Vegetable Crops: Bulbs, Roots and Tubers, Volume 9. Vegetable Crops: Fruits and Young Shoots and Volume 10. Vegetable Crops: Leaves, Flowerheads, Green Pods, Mushrooms and Truffles. This Volume 8, subtitled Vegetable Crops: Bulbs, Roots and Tubers, consists of 12 chapters focusing on advances in breeding strategies using both traditional and modern approaches for the improvement of individual vegetable crops. Chapters are arranged in 3 parts according to the edible vegetable parts. Part I: Bulbs - Garlic, Leek and Shallot; Part II: Roots - Beetroot, Carrot, Parsnip, Radish, Sugar beet and Turnip, Part III: Tubers - Potato and Sweet potato. Each chapter comprehensively reviews the contemporary literature on the subject and reflects the experiences of the authors. Chapters are written by internationally-reputable scientists and subjected to a review process to assure quality presentation and scientific accuracy. Each chapter begins with an introduction covering related backgrounds and provides in-depth discussion of the subject supported with high-quality color photos, illustrations and relevant data. The chapter concludes with recommendations for future research directions, a comprehensive list of pertinent references to facilitate further reading, and appendixes of genetic resources and concerned research institutes. This book series is a valuable resource for advanced students, researchers, scientists, commercial producers and seed companies as well as consultants and policymakers interested in agriculture, particularly in modern breeding technologies.
    Type of Medium: Online Resource
    Pages: XV, 554 p. 105 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030669652
    DDC: 630
    Language: English
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  • 42
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Using electrical stimulation to explore and augment the functions of parietal-frontal cortical networks in primates -- 2. Multi-system benefits of epidural stimulation following spinal cord injury. 3. Neurostimulator for hippocampal memory prosthesis -- 4. Modern approaches to augmenting the brain functions -- 5. Brain machine interfaces within a critical perspective -- 6. An implantable wireless device for ECoG and cortical stimulation -- 7. BCI Performance improvement by special low jitter quasi-steady State VEP paradigm -- 8. Communication with Brain-Computer Interfaces in Medical Decision-Making -- 9. Neuroprotection and neurocognitive augmentation by photobiomodulation -- 10. Avoiding partial sleep - the way for augmentation of brain function -- 11. Augmentation of brain functions by nanotechnology -- 12. The impact of ageing and age-related comorbidities on stroke outcome in animal models and humans -- 13. Diagnostic markers of sub-clinical depression based on functional connectivity -- 14. Transcranial magnetic stimulation in autism spectrum disorders: modulating brainwave abnormalities and behaviors -- 15. Neurofeedback training with concurrent psychophysiological monitoring in children with autism spectrum disorder with comorbid attention deficit/hyperactivity disorder -- 16. Augmentation through interconnection: brain-nets and telemedicine -- 17. Cognitive augmentation via a brain/cloud interface -- 18. Augmentation of neuro-marketing by neural technology -- 19. Augmentation of nutrition by nanotechnology -- 20. Neural spintronics: noninvasive augmentation of brain functions -- 21. Does the power to suppress an action make us free? -- 22. Deep brain stimulation for Parkinson’s disease-future directions for enhancing motor function -- 23. Neuromodulation for gait -- 24. Augmentation and rehabilitation with active orthotic devices -- 25. Effects of rTMS on behavioral and electrocortical measures of error monitoring and correction function in children with autism spectrum disorder -- 26. Affective Virtual Reality Gaming for Autism -- 27. A machine learning approach to automatic phobia therapy with virtual reality -- 28. Vision augmentation by pharmacological enhancement of the visual experience -- 29. Cognitive enhancing substances and the developing brain: risks and benefits -- 30. Pharmacological approaches in the augmentation and recovery of brain function.
    Abstract: This book covers recent advances in the neural technology that produces enhancements for brain function. It addresses a broad range of neural phenomena occurring in the brain circuits for perception, cognition, emotion and action, representing the building blocks of the behavior and mind. Augmentation of brain function is achieved using brain implants for recordings, stimulation and drug delivery. Alternative methods include employing brain-machine interfaces, as well as noninvasive activation of certain brain areas. Existing methods of brain augmentation are evaluated, and new approaches are introduced. Brain circuitry and neuronal mechanisms that are candidates for augmentation are discussed. This volume provides novel insights into brain disorders, and new devices for brain repair. Information in this book is relevant to researchers in the field of neuroscience, engineering, and clinical practice. Philosophical and ethical implications of brain augmentation are also addressed. “This impressive book by leading experts in neuroscience and neuroengineering lays out the future of brain augmentation, in which the human mind and machine merge, leading to a rapid exponential growth of the power of humanity.” – Ray Kurzweil "This book employs a holistic approach in covering the recent advances in the fields of neuroscience, neuroinformatics, neurotechnology and neuro-psycho-pharmacology. Each chapter of the book covers major aspects of modern brain research in connection with the human mind and behavior, and is authored by researchers with unique expertise in their field. " – Ioan Dumitrache “This book presents compelling perspectives on what interactive neuroscience will look like in the future, delving into the innovatory ideas of a diverse set of neuroscientists, and speculating on the different ways computer chips implanted in the brains of humans can effect intelligence and communication.” – György Buzsáki.
    Type of Medium: Online Resource
    Pages: XXII, 747 p. 189 illus., 153 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030545642
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 43
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Agriculture.
    Description / Table of Contents: Chapter 1 The Role of Skepticism in Science? -- Chapter 2 Warnings for Skeptics -- Chapter 3 Photosynthesis -- Chapter 4 Seed Number -- Chapter 5 Nitrogen Use Efficiency -- Chapter 6 Water Use Efficiency -- Chapter 7 Water Loss -- Chapter 8 Unconfirmed Field Observations (UFOs).
    Abstract: Global food production and climate change among other concerns are societal issues that require major research input from crop science. While suggestions are abundant on how crop science can help to resolve these issues, many of the suggestions come from people who are not actually familiar with the challenges and requirements to modify crop plants grown under field conditions to achieve the necessary improvements. Efforts to alter a gene or even several genes have very rarely proven successful in having impact on crop production under realistic field conditions. This lack of success has not been addressed head on. This book serves as a reminder to crop scientists and others that open, clear-minded assessments of the entirety of evidence concerning a hypothesis is required before making claims of possible increases in crop performance. This attitude of skepticism is not a negative attitude but rather an employment of the cornerstone of scientific investigation based on formation and evaluation of hypotheses. Skeptical analyses are to be presented in the book on some of the common suggestions for improving crop plants. The six specific topics to be addressed are photosynthesis, seed number, nitrogen use efficiency, water use efficiency, crop water loss, and unconfirmed field observations. Each of the topics in this book, will first be reviewed to present the origins of the popular assumptions about how specific plant modification will result in improved crop performance. The review of the background information will be followed by an examination of the evidence, logic, and predicted outcomes for the assumed benefits of the modifications. Finally, each chapter will offer novel, alternate approaches to plant modification that have documented support for positively impacting crop performance. The book will not be written in specialized, detail language but offer access for those with a wide range of interests in options for increasing crop production in the future. The goal of the book is to provide information that is useful to those with interests ranging from climatologist to food-oriented sociologists. Of course, the topics covered will be of direct interest to those studying plant sciences, particularly crop scientists. The hope is to challenge a reader to re-examine some of her/his assumptions about crop improvement and approach the topic with a renewed practice of skepticism in formulating and evaluating hypotheses. .
    Type of Medium: Online Resource
    Pages: VI, 66 p. 32 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031144141
    Series Statement: SpringerBriefs in Agriculture,
    DDC: 630
    Language: English
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  • 44
    Keywords: Zoology. ; Environment. ; Bioinformatics. ; Ecology . ; Biodiversity. ; Physical geography. ; Zoology. ; Environmental Sciences. ; Computational and Systems Biology. ; Ecology. ; Biodiversity. ; Earth System Sciences.
    Description / Table of Contents: Introduction -- Historical review of research on Arctic and Subarctic Aleocharinae -- Material and methods -- Impact of climate change on northern fauna and flora -- Aleocharinae as indicators of change -- Faunal analysis and discussion -- Key to tribes occurring in Arctic and Subarctic zones -- Tribe Gymnusini Heer, 1839 -- Tribe Aleocharini Fleming, 1821 -- Tribe Oxypodini C.G. Thomson, 1859 -- Tribe Tachyusini C.G. Thomson, 1859 -- Tribe Hypocyphtini Laporte, 1835 -- Tribe Myllaenini Ganglbauer, 1895 -- Tribe Liparocephalini Fenyes, 1918 -- Tribe Homalotini Heer, 1839 -- Tribe Placusini Mulsant and Rey, 1871 -- Tribe Athetini Casey, 1910 -- Tribe Falagriini Mulsant and Rey, 1873.
    Abstract: Arctic and Subarctic North America is particularly affected by climate change, where average temperatures are rising three times faster than the global average. Documenting the changing climate/environment of the north requires a structured knowledge of indicator taxa that reflect the effects of climate changes. Aleocharine beetles are a dominant group of forest insects, which are being used in many projects as indicators of environmental change. Many species are forest specialists restricted to certain microhabitats, some are generalists and others are open habitat specialists. They represent many ecological niches and, as such, are good indicators for many other species as well. The majority of Canadian aleocharine beetle species (about 600 spp.) has been studied and published by Jan Klimaszewski et al. (2018, 2020), mainly from southern, central, and western Canada, while the northern taxa remain poorly known and documented. The aim of the present book is to summarize the knowledge on this insect group in the Arctic and Subarctic North America and to provide a diagnostic and ecological tool for scientists studying and monitoring insects in northern Canada and Alaska. The book includes a review of the literature, information on 238 species and their habitats, taxonomic review, images, and identification tools.
    Type of Medium: Online Resource
    Pages: XIV, 712 p. 315 illus., 307 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030681913
    DDC: 590
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Reproductive health. ; Cytology. ; Biomedical Research. ; Reproductive Medicine. ; Cell Biology.
    Description / Table of Contents: Ch 1: The seminiferous epithelial cycle of spermatogenesis: Role of non-receptor protein kinases -- Ch 2: Sertoli cells: immunology and spermatogenesis -- Ch 3: Innate immunity and spermatogenesis -- Ch 4: Cell apoptosis and spermatogenesis -- Ch 5: Transcriptional regulation of spermatogenesis -- Ch 6: Sertoli cell cytoskeleton and spermatogenesis -- Ch 7: Leydig cell and spermatogenesis -- Ch 8: Cross-talk of cell junctions to support spermatogenesis -- Ch 9: Coordination of F-actin- and MT-based cytoskeletons to support spermatogenesis -- Ch 10: Regulation of the blood-testis barrier by basement membrane laminin-α2 chain -- Ch 11: Regulation of spermatogenesis by collagens -- Ch 12: Androgen regulation of spermatogenesis -- Ch 13: Use of molecular modeling to study spermatogenesis -- Ch 14: Acrosome biogenesis during spermatogenesis -- Ch 15: Stem cells and spermatogenesis -- Ch 16: Advances in our understanding of spermatogenesis in humans -- Ch 17: Leydig cell function in aging men -- Ch 18: Regulation of human spermatogenesis.
    Abstract: This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.
    Type of Medium: Online Resource
    Pages: X, 319 p. 44 illus., 40 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030777791
    Series Statement: Advances in Experimental Medicine and Biology, 1381
    DDC: 610.72
    Language: English
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  • 46
    Keywords: Food science. ; Food Analysis. ; Chemistry. ; Nutrition   . ; Food Safety measures. ; Food Science. ; Food Chemistry. ; Nutrition. ; Food Safety.
    Description / Table of Contents: Chapter 1 Introduction -- Chapter 2.Global Scenario of Coconut and Coconut Water -- Chapter 3 Tender Coconut Varieties -- 4 Composition, Properties and Reactions of Coconut Water -- Chapter 5 Processing of Coconut Water -- Chapter 6 Packing, Storage and Transport of Coconut Water -- Chapter 7 Standards of Coconut Water -- Chapter 8 Value addition in Coconut Water -- Chapter 9 Health Benefits of Coconut Water -- Chapter 10 Contamination and Adulteration of Coconut Water -- Chapter 11 Patents Granted on Coconut Water -- Chapter 12 Coconut Water- The Way Forward.
    Abstract: Coconut water, a naturally-canned tropical beverage, has been gaining popularity in recent years and has drawn the attention world over as a natural and nutritional wellness beverage. The research published thus far on coconut water has mainly focused on its specific uses, biochemical composition and health benefits as well as processing and preservation techniques and has been published mostly in journal articles. Only a few books covering a wide spectrum of coconut water for health and wellness are currently available. This work offers a comprehensive and fully updated overview of coconut water from processing techniques to value addition to safety to nutritional benefits and beyond. Coconut Water: Processing, Distribution & Nutritional Benefits provides in-depth details on all of the major processing techniques required to produce and maintain a quality product free of contamination and adulteration. The book covers the standards of coconut water production and distribution in various countries enabling the processors and exporters to manufacture and export for better revenue realization. The book also provides details of patents related to coconut water granted to researchers. Another important aspect of this work is comprehensive coverage on the various nutritional and health benefits of coconut water consumption as well as on the value addition (traditional and innovative products). In markets across the world, consumers of all ages have been turning to coconut water for its taste and nutritional benefits. This book will provide researchers, processors and exporters the comprehensive information needed to produce and market quality, nutritional coconut water for consumers. .
    Type of Medium: Online Resource
    Pages: XXXV, 507 p. 57 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031107139
    DDC: 641.3
    Language: English
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  • 47
    Keywords: Medical sciences. ; Ethics. ; Medical education. ; Social sciences. ; Humanities. ; Health Sciences. ; Moral Philosophy and Applied Ethics. ; Medical Education. ; Humanities and Social Sciences.
    Description / Table of Contents: Part 1: Defining Medical Professionalism -- Chapter 1. Professionalism and Medical Practice – Introduction (Luis Vivanco) -- Chapter 2. Medical Professionalism – A Developmental View from the Trenches (Renzo Pegoraro) -- Chapter 3. The Need for a Common Set of Competencies as Ingredients for Medical Professionalism, Paired with a Common Program of Assessment (Aaron R. Douglas) -- Part 2: Medical Professionalism from Broader Perspectives -- Chapter 4. Medical Professionalism – legal framework (Sunčana Roksandić) -- Chapter 5. Medical Professionalism – Sociological Framework (Gordana Cerjan Letica) -- Part 3: The Moral Foundations of Medical Professionalism -- Chapter 6. Medical Professionalism – Philosophical Framework (Marko Ćurković) -- Chapter 7. Medical Professionalism from Virtue Ethics Perspective (Claudia Ruiz Sotomayor) -- Part 4. Medical Professionalism – Interpersonal Views and Considerations -- Chapter 8. Interpersonal or Relational Professionalism (Marko Ćurković) -- Chapter 9. The Physician Patient Relationship: a Philosophical Perspective on Medical Professionalism and Virtues (Roberto Dell’Oro) -- Chapter 10. Physicians Towards Fellow Colleagues (Marko Ćurković) -- Chapter 11. Physicians Towards Other Healthcare Professionals (and Vice Versa) (Marko Ćurković) -- Chapter 12. Interdisciplinary Challenges to Interprofessional Practice (Jos V. M. Welie) -- Part 5. Medical Professionalism – Unique Challenges and Duties -- Chapter 13. The Impact of Uncertainties on Physicians’ Health and Wellbeing (Marko Ćurković) -- Chapter 14. Physicians and Organization: For a Reflective Organizational Professionalism (Jean-Philippe Cobbaut) -- Chapter 15. Victims or Actors? Can Professionalism Shape Physicians’ Roles Inside the Health Care System? (Bernice Elger) -- Chapter 16. What do Doctors and Society Owe Each Other? A Scanlonian Reflection on Medical Professionalism (Andrew Papanikitas) -- Chapter 17. Physicians Towards Society (and Vice Versa) (Sabine Salloch) -- Part 6: Medical Professionalism Across Contemporary and Cultural Landscapes -- Chapter 18. Professionalism and Medical Practice - Cultural Perspectives (Marko Ćurković) -- Chapter 19. Physicians as Citizens of the World (Henk ten Have) -- Chapter 20. Physicians as Agents in Evolving Knowledge Landscapes (Srećko Gajović) -- Chapter 21. Afterthoughts: Towards a Realpolitik of Professionalism (Nathan Emmerich).
    Abstract: This book provides insights into dynamic and complex interrelationships between professionalism and medical practice. It does so by looking into the most relevant and recent theoretical and practical frameworks and by systematizing and integrating extensive and growing literature on medical professionalism. Through honest and prudent contributions from very diverse backgrounds and contexts, this book provides an understanding of medical professionalism derived from a broader historical and cultural context in order to contribute to everyday professional life and practice – the very place of its existence. The book presents the conflicting and sometimes irreconcilable demands and challenges physicians face in everyday practice. A better understanding of these fundamental issues is the only way for medicine to maintain and preserve its unique morality, the same one that enabled its existence in the first place. The book is relevant for everyone immersed and interested in the subject of medical professionalism as a resource, which may ease or guide them through the complexities of issues at hand. It will also contribute to the ongoing debate on medical professionalism, medical ethics, bioethics, and professionalism and ethics in general.
    Type of Medium: Online Resource
    Pages: XXI, 493 p. 59 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031097331
    Series Statement: The International Library of Bioethics, 98
    DDC: 610
    Language: English
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    Keywords: Biomaterials. ; Nanotechnology. ; Biomedical engineering. ; Polymers. ; Microfluidics. ; Biomaterials. ; Nanotechnology. ; Biomedical Engineering and Bioengineering. ; Biomedical Materials. ; Polymers. ; Microfluidics.
    Description / Table of Contents: Introduction to high resolution manufacturing from 2D to 3D/4D printing -- Technologies evolutions and Design Considerations -- Vat photopolymerization -- Stereolithography -- Digital Light Processing -- Continuous liquid interface production -- Materials -- Multi-photon polymerization -- 2PP -- Materials -- Powder bed fusion -- Selective Laser Sintering -- Materials -- Commodity Polymers -- Engineering Polymers -- High-Performance Polymers -- Thermoplastic Elastomers -- The role of fillers -- Ink-jet printing -- Polyjet printing -- Aerosol jet printing -- Materials -- Volumetric 3D printing -- Computed Axial Lithography -- Xolography -- Materials -- Impact on different research fields and case studies -- Biomedical applications -- Cells culture, Microfluidics, rapid diagnostic tools -- Electronic applications -- Sensors and biosensors, actuators, integrated circuits -- Energy applications -- Supercapacitors, Energy harvesting -- Photonic applications -- Woodpile structures, light guides, optical fiber -- Future outlook.
    Abstract: This book provides a comprehensive presentation of the most frequently used high resolution manufacturing techniques available, as well as the polymeric materials used for each of the techniques. Divided into two parts covering the technologies and materials used and the impact on different research fields and case studies, High Resolution Manufacturing from 2D to 3D/4D Printing: Applications in Engineering and Medicine addresses issues like throughput improvement by volumetric 3D printing and presenting novel applications and case studies. In addition, this book also covers the latest breakthrough developments and innovations to help readers understand the future applications of this technology across various disciplines, including biomedicine, electronics, energy, and photonics.
    Type of Medium: Online Resource
    Pages: X, 300 p. 128 illus., 112 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031137792
    DDC: 620.19
    Language: English
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  • 49
    Keywords: Agriculture. ; Soil science. ; Plant biotechnology. ; Agronomy. ; Stress (Physiology). ; Plants. ; Plant diseases. ; Agriculture. ; Soil Science. ; Plant Biotechnology. ; Agronomy. ; Plant Stress Responses. ; Plant Pathology.
    Description / Table of Contents: 1. Soybean: A Key player for global food security -- 2. Dissection of Physiological and Biochemical Bases of Drought tolerance in Soybean (Glycine max) Using recent Phenomics approach -- 3. Soybean Improvement for Water-logging Tolerance -- 4. Salinity tolerance in Soybeans: Physiological, molecular and genetic perspectives -- 5. Utility of Network Biology Approaches to Understand the Aluminium Stress Responses in Soybean -- 6. Advances in Molecular markers to develop Soybean cultivars with increased protein and oil content -- 7. Soybean Breeding for Rust Resistance -- 8. Molecular breeding for resistance against pythium root rot (PRR) in soybean -- 9. Molecular Breeding for Resistance against Phytophthora in Soybean -- 10. Mitigation of Soybean Mosaic Virus Using an Efficient Molecular Approach -- 11. Transgenic Approach: A Key to Enrich Soybean Oil Quality -- 12. miRNAs in soybean improvement -- 13. Genome Editing Advances in Soybean Improvement against Biotic and Abiotic stresses.
    Abstract: Soybean (Glycine max L. (Merr)) is one of the most important crops worldwide. Soybean seeds are vital for both protein meal and vegetable oil. Soybean was domesticated in China, and since last 4-5 decades it has become one of the most widely grown crops around the globe. The crop is grown on an anticipated 6% of the world’s arable land, and since the 1970s, the area in soybean production has the highest percentage increase compared to any other major crop. It is a major crop in the United States, Brazil, China and Argentina and important in many other countries. The cultivated soybean has one wild annual relative, G. soja, and 23 wild perennial relatives. Soybean has spread to many Asian countries two to three thousand years ago, but was not known in the West until the 18th century. Among the various constraints responsible for decrease in soybean yields are the biotic and abiotic stresses which have recently increased as a result of changing climatic scenarios at global level. A lot of work has been done for cultivar development and germplasm enhancement through conventional plant breeding. This has resulted in development of numerous high yielding and climate resilient soybean varieties. Despite of this development, plant breeding is long-term by nature, resource dependent and climate dependent. Due to the advancement in genomics and phenomics, significant insights have been gained in the identification of genes for yield improvement, tolerance to biotic and abiotic stress and increased quality parameters in soybean. Molecular breeding has become routine and with the advent of next generation sequencing technologies resulting in SNP based molecular markers, soybean improvement has taken a new dimension and resulted in mapping of genes for various traits that include disease resistance, insect resistance, high oil content and improved yield. This book includes chapters from renowned potential soybean scientists to discuss the latest updates on soybean molecular and genetic perspectives to elucidate the complex mechanisms to develop biotic and abiotic stress resilience in soybean. Recent studies on the improvement of oil quality and yield in soybean have also been incorporated.
    Type of Medium: Online Resource
    Pages: VIII, 276 p. 37 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031122323
    DDC: 630
    Language: English
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  • 50
    Keywords: Veterinary medicine. ; Medicine Research. ; Biology Research. ; Biometry. ; Veterinary Science. ; Biomedical Research. ; Biostatistics.
    Description / Table of Contents: An introduction to reproducibility in the context of animal research -- Rodent Genetics -- Animal and environmental factors that influence reproducibility -- Microbiology and Microbiome -- Effects of untreated pain, anesthesia and analgesia in animal experimentation -- Why do we need a statistical experiment design -- Statistical tests and Sample size calculations -- Design of experiments -- Scholarly Publishing and Scientific Reproducibility -- Systematic reviews -- Planning animal experiments.
    Abstract: This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. The book addresses advanced undergraduates, graduate students and all scientists working with animals.
    Type of Medium: Online Resource
    Pages: VI, 277 p. 52 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030661472
    Series Statement: Laboratory Animal Science and Medicine, 1
    DDC: 636.089
    Language: English
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  • 51
    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Entrepreneurship. ; New business enterprises. ; Public health. ; Biotechnology. ; Biomedical Research. ; Entrepreneurship. ; Public Health.
    Description / Table of Contents: Part I. What Is Wrong with Health? What Should the Future of Health Be? -- INNOVATION DESIGN for the FUTURE of HEALTH -- Health Innovations from an Innovators’ Perspective -- From SICKCARE to HEALTHCARE to HEALTH -- Future Look on Health: Opportunities -- Navigating Towards a Future of “One Health” -- Part II. Exponential Medicine + Technologies + Mindset -- Exponential Technologies for an Exponential Medicine -- Exponential Medicine: Challenges of Human Spaceflight Bringing Innovations for Earth—A Case Study -- Healthy Longevity -- The Science of Health Longevity -- Space Healthtech: Innovation Base for Longevity -- Part III. Future Health Value Propositions -- Healthcare the Melting Pot of Technology, Humanity, and Confusion -- Democratize Health Delivery -- Health Innovation Process: Definitions and Short Methodology Introductions -- Prevention, Prediction, Personalization, and Participation as Key Components in Future Health -- Digital Health Business Models: Transformation Is on the Horizon -- Value Propositions for Future Health Developments: Digital, Portable, Connected, Experience-Enhancing, Supportive, Patient-Centric, and Affordable -- (Digital) Patient Journey and Empowerment: Digital Twin -- Part IV. Innovation Methodology Basics -- Stanford Biodesign as Base: Empathy and Patient Centricity as the Main Driver -- Purpose Launchpad Methodology: Introduction -- Design Thinking for Innovations in Healthcare -- VPC to BMC to Exponential Canvas: Canvas Interconnectivity for Exponential Scaling -- Innovation Methodology I3 EME: Awareness for Biomedical Engineers -- Part V. Ethics + Health Innovation -- Integrating Ethical Considerations into Innovation Design -- Part VI. Health Innovation Design -- Case Studies Used Throughout the Book: Innovation Categories Explained -- Why Is Healthcare Different with Respect to Innovation and Entrepreneurial Activities? -- Purpose Launchpad Health (PLH) Methodology Introduction -- Part VII. Purpose Launchpad Health -- Purpose Launchpad Health: Exploration and Evaluation Phases—Actual Case Studies -- Part VIII. Health Leadership, Skills and other Methodologies -- Soft Skills Needed for Problem Understanding and Innovation Generation -- Leadership in Healthcare: A Novel Approach. Healthcare Executives’ Traits, Styles, and Approaches -- Future Skills Framework in Healthcare -- Porter’s Five Forces Analysis: Quo Vadis Immunotherapy Industry -- Part IX. Health Entrepreneurship -- Global Health Markets and Their Different Needs -- Patient: Health Relation and Digital Health Entrepreneurship -- Health Start-Up: Create Impact and be Investment Ready Intra- and Entre-Preneurs -- Regulatory Issues for Health Innovations -- Innovation Think Tank Frameworks for Resolving “The Innovator’s Dilemma” in Healthcare -- A Primer on Patents and IP for Health Innovations -- Successfully Implementing Ambidexterity in the Medical Industry -- Reverse Innovation: Circumvent Digital Health Transformation Issues -- Part X. Health Innovation Education and Incubation -- Health Innovation Design: “CAMPing” for the Unmet Clinical Need -- Health Technology Innovation Generation (HTIG) Lecture and Project Classes at AGH University -- Health Innovation Design at a University: INKA INNOLAB at Otto-von-Guericke-University -- Clinical Innovation at Acibadem Biodesign Center -- Example of a Needs-Driven Innovation Training Program: The BioMedical Design Novo Nordisk Foundation Fellowship Program -- Addressing the Healthcare Needs with Innovation Think Tank Global Infrastructure and its Methodology -- The Power of a Collaborative Ecosystem: Introducing the Edison™ Accelerator -- HealthTec Networks and Clusters (Global): Innovation Clusters in Medtech in Europe -- Leadership-Compass: “Networking and Synapting Empowered by Health Captains” -- Part XI. Purpose Launchpad Health: Toolset Templates and Principles -- PLH Templates and Principles.
    Abstract: This book highlights the reasons for an urgently needed revision of the current global healthcare setup, discusses the needed mindset for a future of health, and provides a comprehensive development toolset for disruption (and for the needed incremental innovations towards disruption). Today’s biomedical and health innovation related research in universities encourages activities that lead to incremental innovations with a relatively low risk of failure. The healthcare industry on the other hand provides tools and devices for established healthcare providers to improve the diagnosis and therapy/ treatment of the patients’ health problems. The patient is not in the center of healthcare provision however, and prevention and prediction are not core goals. The current health setup needs to be challenged and disrupted. Disruptions are coming from technologies or processes that lead to a significant (〉10x) reduction in cost or price/ performance and that also come with new business models. The need for change, effects of exponential technologies, and the needed shift to prevention and to homecare for health democratization and patient empowerment will be discussed in detail in the first parts of the book. The subsequent sections address several innovation methods with a focus on a novel meta methodology named Purpose Launchpad Health. This is followed by a comprehensive discussion on health entrepreneurship activities and needs. The final section of the book addresses how to train students to become entrepreneurial health innovators, presenting successful curricula and examples of health incubation and accelerator setups. All of the innovation tools presented and used in this book are summarized in the final chapter to help the reader get started planning an entrepreneurial venture. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments. Chapters are concise and enriched with key messages, learning objectives and real innovation examples to bridge theory and practice. This book aims to serve as a teaching base for health innovation design and to prepare for health-related entrepreneurial ventures. Readers with medical, biomedical, biotechnology, and health economics backgrounds - and anyone who wants to become a future oriented health innovator or who believes in disruptive approaches - will find this book a useful resource and teaching tool for developing validated products/ services and processes for the future of health.
    Type of Medium: Online Resource
    Pages: XXXIV, 624 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031081910
    DDC: 660.6
    Language: English
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    Keywords: Botany. ; Nutrition   . ; Medicinal chemistry. ; Food science. ; Plant Science. ; Nutrition. ; Medicinal Chemistry. ; Food Science.
    Description / Table of Contents: Foreword -- Preface -- Wetlands and Wetland Plants -- Climate of Wetlands -- Types of Wetlands and Wetland Plants -- Importance of Biodiversity in Wetlands -- Nutritive Value of Wetland Flora -- Medicinally Important Wetland Flora -- Threats to Biodiversity of Wetlands -- Conservation Strategies of Wetland Flora -- Wetland Plants of Himalayas: A case study -- A Pictorial Guide to Wetland plants of Himalayas -- Bibliography.
    Abstract: Due to their high nutritive value and the presence of secondary metabolites, wetland plants can be consumed by humans as food and utilized as medicinal drugs. Significant numbers of ethno-botanic resources have been reported to extract useful compounds, which can be used as pharmaceuticals. Wetland plants are also very valuable as an energy source, as fuel for fish smoking and for domestic energy. These plants can be harvested as wild stock, or cultivated in flooded paddies for aquaculture, food and for livestock fodder. All parts of plants can be utilized for foodstuff, compost, mulch, medicine, and for construction. Wetland Plants: A Source of Nutrition and Ethnomedicine aims to promote public understanding of this remarkable resource, exploring not only their role in the ecosystem but also their nutritional and medicinal purposes. Based on original research, the text focuses on species identification (with original pictures of wetland plants including morphological features), nutritive value and ethno-medicinal uses. This book serves as an important and basic reference material for further research into the basic biological as well as the applied medicinal aspects of traditional medicinal wetland plants.
    Type of Medium: Online Resource
    Pages: XXIX, 228 p. 149 illus., 148 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030692582
    DDC: 580
    Language: English
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  • 53
    Keywords: Evolution (Biology). ; Anatomy. ; Physical anthropology. ; Physiology. ; Ecology . ; Evolutionary Biology. ; Anatomy. ; Physical-Biological Anthropology. ; Animal Physiology. ; Ecology.
    Description / Table of Contents: Introduction -- Clinical and Evolutionary Perspectives on the Primate Foot: A Historical and Contemporary View -- The Primate Ankle and Hindfoot -- The Primate Midfoot and Human Longitudinal Arch -- The Primate Forefoot -- Myology of the Primate Foot -- The Integument and Associated Structures of the Primate Foot -- Experimental Research on Foot Use and Function During Climbing by Primates -- Foot Posture During Quadrupedal Walking in Primates -- Primate Foot Use During Bipedal Walking -- Running in Addition to Walking Helped Shape the Human Foot -- The Feet of Paleogene Primates -- Miocene Ape Feet -- The Early Hominin Foot -- The Feet of Fossil Homo -- Locomotor behavior of the sloth lemurs (Palaeopropithecidae) and the function and anatomy of a foot adapted for suspensory locomotion -- Recent Developments and Future Directions for the Study of Primate Feet.
    Abstract: The human foot is a unique and defining characteristic of our anatomy. While most primates have grasping, prehensile feet, the human foot stands out as a powerful non-grasping propulsive lever that is central to our evolution as adept bipedal walkers and runners. Very few books have compiled and evaluated key research on the primate foot and provided a perspective on what we know and what we still need to know. This book serves as an essential companion to “The Evolution of the Primate Hand” volume, also in the Developments in Primatology series. This book includes chapters written by experts in the field of morphology and mechanics of the primate foot, the role of the foot in different aspects of primate locomotion (including but not limited to human bipedalism), the “hard evidence” of primate foot evolution including fossil foot bones and fossil footprints, and the relevance of our foot’s evolutionary history to modern human foot pathology. This volume addresses three fundamental questions: (1) What makes the human foot so different from that of other primates? (2) How does the anatomy, biomechanics, and ecological context of the foot and foot use differ among primates and why? (3) How did foot anatomy and function change throughout primate and human evolution, and why is this evolutionary history relevant in clinical contexts today? This co-edited volume, provides, for the first time, a comprehensive review and scholarly discussion of the primate foot from multiple perspectives. It is accessible to readers at different levels of inquiry (e.g., undergraduate/graduate students, postdoctoral researchers, other scholars outside of biological anthropology). This volume provides an all-in‐one resource for research on the comparative and functional morphology and evolution of the primate foot.
    Type of Medium: Online Resource
    Pages: XI, 527 p. 104 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031064364
    Series Statement: Developments in Primatology: Progress and Prospects,
    DDC: 576.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical microbiology. ; Parasitology. ; Biomedical Research. ; Medical Microbiology. ; Parasitology.
    Description / Table of Contents: Preface -- Chapter1. Advances in experimental research about periodontitis: lessons from the past, ideas for the future (Julien Santi-Rocca) -- Part I: Periodontal microbiota -- Chapter 2. Microbiota in Periodontitis: advances in the omic era (Shao Bing Fong, Emile Boyer, Martine Bonnaure-Mallet, Vincent Meuric) -- Chapter 3. Aggregatibacter actinomycetemcomitans: from basic to advanced research (Abdelhadi Hbibi, Amal Bouziane, Badiaa Lyoussi, Mimoun Zouhdi, Driss Benazza) -- Chapter 4. Meta-analyses on the Periodontal Archaeome (Jéssica Alves de Cena, Yuri Silvestre-Barbosa, Aline Belmok, Cristine Miron Stefani, Cynthia Maria Kyaw, Nailê Damé-Teixeira) -- Chapter 5. Parasites in periodontal health and disease: a systematic review and meta-analysis (David Felipe Martin-Garcia, Malik Sallam, Gabriela Garcia, Julien Santi-Rocca) -- Chapter 6. Fungi - a component of the oral microbiome involved in periodontal diseases (Justyna Karkowska-Kuleta, Dorota Satala, Magdalena Smolarz, Marcin Zawrotniak, Maria Rapala-Kozik) -- Chapter 7. Herpesviruses in periodontitis: An umbrella review (Aleksandar Jakovljevic, Miroslav Andric, Jelena Jacimovic, Jelena Milasin, Javier Enrique Botero) -- Part II: Periodontitis pathophysiology -- Chapter 8. Recent updates on microbial biofilms in periodontitis: an analysis of in vitro biofilm models (Maick Meneguzzo Prado, Nathalia Figueiredo, Andréa Pimenta, Tamires Szeremeske Miranda, Magda Feres, Luciene Cristina Figueiredo, Josiane de Almeida, Bruno Bueno-Silva) -- Chapter 9. Update on B cell response in periodontitis (Julien Demoersman, Jacques Olivier Pers) -- Chapter 10. Polarization profiles of T lymphocytes and macrophages responses in periodontitis (Franco Cavalla, Marcela Hernández) -- Chapter 11. Complementary experimental methods in genetics open up new avenues of research to elucidate the pathogenesis of periodontitis (Arne S. Schaefer) -- Part III: Periodontitis-associated conditions -- Chapter 12. Update on the bidirectional link between diabetes and periodontitis (Leila Salhi, Michèle Reners) -- Chapter 13. Periodontitis as a risk factor for Alzheimer’s disease: the experimental journey so far, with hope of therapy (Alice Harding, Shalini Kanagasingam, Richard Welbury, Sim K. Singhrao) -- Chapter 14. Cardiovascular diseases and periodontitis (Peter Riis Hansen, Palle Holmstrup) -- Part IV: Therapeutic management of periodontitis -- Chapter 15. Update on the role of cytokines as oral biomarkers in the diagnosis of periodontitis (Triana Blanco-Pintos, Alba Regueira-Iglesias, Carlos Balsa-Castro, Inmaculada Tomás) -- Chapter 16. Non-surgical periodontal treatment: SRP and innovative therapeutic approaches (Alexia Vinel, Antoine Al Halabi, Sébastien Roumi, Hélène Le Neindre, Pierre Millavet, Marion Simon, Constance Cuny, Jean-Sébastien Barthet, Pierre Barthet, Sara Laurencin-Dalicieux) -- Chapter 17. Update on the roles of oral hygiene and plaque control on periodontal disease (Leila Salhi, Bruno De Carvalho, Michèle Reners) -- Chapter 18. Multi-photonic adjunctive therapy for the management of periodontitis: recent advances and new treatment approach (Marco Giannelli, Daniele Bani) -- Chapter 19. Probiotics during the therapeutic management of periodontitis (Flavia Furlaneto, Karin Hitomi Ishikawa, Michel Reis Messora, Marcia P A Mayer) -- Chapter 20. Periodontal cell therapy: a systematic review and meta-analysis (Antoine Dubuc, Valérie Planat-Bénard, Mathieu Marty, Paul Monsarrat, Philippe Kémoun) -- Index.
    Abstract: Periodontitis is a disease that affects more than half the adult population in the world. Treatment is often based on ancient recommendations consisting in mechanically removing material from damaged zones. However, novel therapeutic management strategies exist, from prevention to efficient treatment, and regeneration. The need of integrative approaches to circumvent this worldwide pledge can be achieved through: A better understanding of this complex disease by promoting scientific research and a comprehensive multidisciplinary approach, including epidemiology, microbiology, immunology, physiology, therapeutics, psychology, etc. A better outreach by promoting vulgarization and recommendations for health professionals. A better information of the empowered patients, leading them to consider prevention and to take part in their therapeutic course. The book “Periodontitis: Advances in Experimental Research” includes a timely collection of chapters covering all the fields of research about periodontitis, consisting in concise reviews by the best specialists themselves and with clinical perspectives for periodontitis. Recent technological advances have allowed to explore shadowed areas of periodontology. The book “Periodontitis: Advances in Experimental Research” is a unique occasion to set a milestone for a more integrated field of periodontitis, with a broad scientific, medical, and public audience thanks to dedicated sections in each chapter: Abstract and main body (scientific audience and expert clinicians) Highlights (scientific audience and clinicians) Impact for Practice (clinicians and economical/political decision makers) Summary for Patients (patients and economical/political decision makers).
    Type of Medium: Online Resource
    Pages: XIII, 402 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030968816
    Series Statement: Advances in Experimental Medicine and Biology, 1373
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Veterinary medicine. ; Otorhinolaryngology. ; Physiology. ; Dermatology. ; Veterinary Clinical Medicine. ; Otorhinolaryngology. ; Animal Physiology. ; Dermatology.
    Description / Table of Contents: Chapter 1. Technical Information of the Video-Oto-Endoscope -- Chapter 2. Patient Preparation and Otoendoscopy Operative Procedure -- Chapter 3. Ear Anatomy -- Chapter 4. Video Otoscopy Procedures -- Chapter 5. Indications of VOE in Canine and Feline Ear Diseases.
    Abstract: This atlas provides a step-by-step manual in using the video-oto-endoscope (VOE) as a tool to study ear diseases in cats and dogs. Illustrated by numerous high-resolution images and case studies, the book explains in a highly accessible manner when and how to use VOE. It teaches how to differ between a normal and a pathological animal ear and guides the reader in diagnosing a particular disease. The book's main section provides in-depth information on causes, clinical picture, and imaging of ear diseases such as acute otitis externa, chronic otitis externa, and otitis media in small animals. Moreover, the atlas introduces technical fundamentals of the instrument and gives tips for its correct handling and cleaning. Further, readers are instructed on how to best prepare the animal patient for examination by VOE. The atlas addresses veterinary practitioners and veterinary technicians who are interested in performing otological examinations in cats and dogs. .
    Type of Medium: Online Resource
    Pages: XIII, 185 p. 252 illus., 236 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030989118
    DDC: 636.0896
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Immunology. ; Autoimmunity. ; Inflammation. ; Immunogenetics. ; Tumors Immunological aspects. ; Immunology. ; Translational Immunology. ; Autoimmunity. ; Inflammation. ; Immunogenetics. ; Tumour Immunology.
    Description / Table of Contents: 1 Cells and tissues of the immune system -- 2 Innate immunity and inflammation -- 3 Adaptive immunity and antigen receptor diversity -- 4 B cell immunity: BCRs, antibodies and their effector functions -- 5 Antigen-presenting cells and the major histocompatibility complex -- 6 T cell immunity: TCRs and their effector functions -- 7 Immunity to bacterial pathogens and the microbiome -- 8 Immunity to viral pathogens and the virome -- 9 Tolerance and transplantation immunology -- 10 Immunological hypersensitivities: Allergy and autoimmunity -- 11 Cancer immunology.
    Abstract: This textbook aims to describe in a condensed form the essentials of molecular immunology behind bacterial infections, the microbiome, viral infections (such as influenza and COVID-19), organ transplantations, autoimmunity, allergy and tumor immunology. The book emphasizes the impact of immunology in maintaining our health and preventing disease. Our immune system protects us not only from severe consequences of infectious diseases and getting cancer, but is also able to harm us severely via sepsis, cytokine storms and anaphylactic shocks. Molecular understanding of immunology should allow the reader a more rational handling of common diseases, most of which are associated with chronic inflammation.
    Type of Medium: Online Resource
    Pages: XV, 219 p. 94 illus., 93 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031040252
    DDC: 571.96
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Virology. ; Microbial ecology. ; Virology. ; Microbial Ecology.
    Description / Table of Contents: Chapter 1. Bacteriophages, a Brief Introduction -- Chapter 2. A Closer Overview of Phage Infections -- Chapter 3.Evolutionary Biology Basics -- Chapter 4. Brief Introduction to Phage Ecology -- Chapter 5.Bacterial Mutation Associated with Phages: Insertions -- Chapter 6. Bacterial Mutation Associated with Phages: Deletions -- Chapter 7. Genetic Drift and Phages -- Chapter 8. Phages and Asexual Bacterial Populations -- Chapter 9.Phage Impact on Non-Random Mating Among Bacteria -- Chapter 10. Genetic Migration and Phages -- Chapter 11. Bacterial Reproductive Isolation and Its Violation by Phages -- Chapter 12. Phage-Provided Environmental DNA and Superspreading -- Chapter 13. Transduction of Large Amounts of DNA -- Chapter 14. Phage Morons -- Chapter 15. Why Lysogenic Conversion? -- Chapter 16. Prophages Preventing Phage Superinfection -- Chapter 17. Domestication of Phage Genes -- Chapter 18.Resistance to Phages, Part I: Overview -- Chapter 19. Resistance to Phages, Part II: Bacteria Live! -- Chapter 20.Resistance to Phages, Part III: Bacteria Die..-Chapter 21. Bacterial Mutation to Phage Resistance -- Chapter 22. Pleiotropic Costs of Phage Resistance -- Chapter 23. Concepts of Natural Selection in Light of Phage Exposure -- Chapter 24. Frequency-Dependent Selection in Light of Phage Exposure -- Chapter 25. A Primer on Phage-Bacterium Antagonistic Coevolution.
    Abstract: This monograph emphasizes the many facets of bacterial evolution as impacted by bacterial interactions with phages, as well as, to a lesser degree, the evolutionary impact of phages on other organisms, including other phages. The book starts with a general overview of bacteriophages. Topics discussed in detail include but are not limited to mutagenesis, migration, natural selection and genetic drift as the drivers of evolution as well as an extensive discussion from the author’s unique perspective on phage ecology. .
    Type of Medium: Online Resource
    Pages: XXV, 377 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030943097
    DDC: 579.2
    Language: English
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  • 58
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical sciences. ; Medicine Research. ; Biology Research. ; Science Social aspects. ; Communication in science. ; Penmanship. ; Health Sciences. ; Biomedical Research. ; Science and Technology Studies. ; Science Communication. ; Writing Skills.
    Description / Table of Contents: Part I. Introduction: The Pathway to Publishing -- Part II. Most common errors -- 1. General research and writing practices -- 2. Content of quantitative papers -- 3. Mechanics of writing -- 4. Grammatical structures and stylistic strategies -- 5. Achieving clarity and conciseness -- 6. Recording scientific data -- 7. Approaching publication -- 8. Slide and poster presentations.
    Abstract: Writing manuscripts is central to the advance of scientific knowledge. For an early career aspiring scientist, writing first author manuscripts is an opportunity to develop critical skills and to credential their expertise. Writing manuscripts, however, is difficult, doubly so for scientists who use English as a second language. Many science students intentionally avoid a writing-intensive curriculum. Careful, thorough reviews of draft manuscripts are difficult to secure, and experienced scientific supervisors face more demands on their time than they have time available. Weak draft manuscripts discourage supervising scientists investing the time to coach revisions. It is easier for experienced scientists to ignore the request, or to simply rewrite the article. Early career scientists are motivated to address these barriers but specific advice is difficult to find, and much of this advice is behind a pay wall. This essential, open access text presents writing lessons organized as common errors, providing students and early-career researchers with an efficient way to learn, and mentors with a quick-reference guide to reviewing. Error descriptions include specific examples drawn from real-world experiences of other early-career writers, and suggestions for how to successfully address and avoid these in the future. Versions of this book have been used by Stanford University, UC Davis, Johns Hopkins, and numerous international institutions and organizations for over a decade. This book is licensed under the terms of the Creative Commons Attribution 4.0 International License "http://creativecommons.org/licenses/by/4.0/", which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made The images or other third party material in this book are included in the book's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the book's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
    Type of Medium: Online Resource
    Pages: XIII, 186 p. 55 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030981754
    DDC: 610
    Language: English
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    Keywords: Toxicology. ; Reproductive health. ; Reproduction. ; Physiology. ; Cytology. ; Developmental biology. ; Environmental chemistry. ; Toxicology. ; Reproductive Medicine. ; Reproductive Physiology. ; Cell Biology. ; Developmental Biology and Stem Cells. ; Environmental Chemistry.
    Description / Table of Contents: Oxidative stress and toxicity in reproductive biology and medicine: Historical perspectives and future horizons in male fertility -- Reactive Oxygen Species in the Reproductive System: Sources and Physiological Roles -- Pathological Roles of Reactive Oxygen Species in Male Reproduction -- Molecular Interactions Associated with Oxidative Stress Mediated Male Infertility: Sperm and Seminal Plasma Proteomics -- Unraveling the Molecular Impact of Sperm DNA Damage on Human Reproduction -- Role of Infection and Leukocytes in Male Infertility -- Bacteriospermia and Male Infertility: Role of Oxidative Stress -- Oxidant-Sensitive Inflammatory Pathways and Male Reproductive Functions -- Oxidative Stress and Idiopathic Male Infertility -- Oxidative Stress and Varicocele-Associated Male Infertility -- Oxidative Stress in Men with Obesity, Metabolic Syndrome and Type 2 Diabetes Mellitus: Mechanisms and Management of Reproductive Dysfunction -- Metabolic dysregulation and sperm motility in male infertility -- Tale of viruses in male infertility -- Pathogenesis of Viral Infections and Male Reproductive Health: An Evidence-Based Study -- Sperm redox system equilibrium: Implications for fertilization and male fertility.
    Abstract: This book discusses the role of oxidative stress in human reproduction with a focus on men’s health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction . The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men’s health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.
    Type of Medium: Online Resource
    Pages: XII, 379 p. 28 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030893408
    Series Statement: Advances in Experimental Medicine and Biology, 1358
    DDC: 615.90072
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Neurosciences. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Cell Biology. ; Neuroscience. ; Biomedical Research. ; Pharmacology.
    Description / Table of Contents: A historical and evolutionary view of tight junctions -- Tricellular tight junctions -- Mechanosensitivity of tight junctions -- Intracellular traffic and non-canonical roles of ZO-2 protein -- Impact of claudin-2 and occludin expression in inflammation disorders -- Tight junctions in the inflamed gut -- Intestinal barrier disruption by enteropathogenic Escherichia coli -- Tight junction barrier function regulation by microbiota -- Claudin-7 participation in cell-substrate adhesion, cell migration, salt balance in the renal collecting duct and gut cell renewal and differentiation -- Regulation of the alveolar epithelial barrier by claudin-5 -- Regulation of the blood-retinal barrier by occludin phosphorylation, norrin and sonic hedgehog signaling -- Transmigration of metastatic cells through the blood-brain barrier -- Endocytosis of tight junction proteins -- Regulated degradation of claudins. .
    Abstract: This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.
    Type of Medium: Online Resource
    Pages: XII, 334 p. 47 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030972042
    DDC: 571.6
    Language: English
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    Keywords: Urban ecology (Biology). ; Geography. ; Public health. ; Medicine, Preventive. ; Health promotion. ; Urban Ecology. ; Regional Geography. ; Public Health. ; Health Promotion and Disease Prevention.
    Description / Table of Contents: Introduction (Elisa Pozo Menéndez) -- Part 1. The post-pandemic city for healthy ageing and wellbeing -- Chapter 1. Urban planning and health equity. Integrating global and European perspectives in local (Ângela Freitas) -- Chapter 2. Social innovation and adaptability for ageing in place in cities: a comparison between France and Japan (Camille Picard) -- Chapter 3. Silver cities: attractive cities for elderly (Montserrat Calvo) -- Chapter 4. Quality of life, living arrangements and care support for the older population (Carmen Rodriguez-Blazquez) -- Chapter 5. Active Ageing and Age-Friendly Communities: constructing an image of old age and ageing (Gloria Fernández-Mayoralas) -- Chapter 6. Comprehensive perspective of care design for the accompaniment of the person during the life journey (Álvaro García Soler) -- Chapter 7. Resilient cities and built environment. Urban design, citizens and health. Learning from COVID-19 experiences (Miguel Padeiro) -- Part 2. An inclusive environment: alternatives and challenges for ageing in place in North and South European Cities -- Chapter 8. Framework for inclusive residential projects for all: further research lines (Rose Gilroy) -- Chapter 9. Housing for an active ageing. Learning and outcomes from the Danish paradigm and the application to the Spanish context. Lugaritz Lifetime Homes in Donostia - San Sebastián (Heitor García Lantarón) -- Chapter 10. Development and Management of Cohousing Initiatives for a Friendly Ageing in Spain (Fermina Rojo-Pérez) -- Chapter 11. An evidence-based approach to optimize age-care facility design for People with Dementia (Neveen Hamza) -- Chapter 12. Thermal comfort for older population in Spain. Diagnosis and strategies for a climate change scenario (Emilia Román López) -- Chapter 13. Use of public spaces by older adults. Comparison among Madrid and Newcastle Upon Tyne (María Teresa Baquero Larriva) -- Chapter 14. Greenery urban design for good mental health. Analysis of a vulnerable district of Madrid (Elisa Pozo Menéndez) -- Chapter 15. Dementia-friendly communities and challenges from built environment design. The Belgian case (Veerle Baert) -- Chapter 16. The covered market between crossroads and narration of memories. A brief glimpse of an Italian market and the imagery that runs through it between past and present (Caterina Gallerani) -- Chapter 17. Inclusive innovation for age-friendly environments. The role of Living Labs dynamics in territories (Luciana Castro Gonçalves) -- Chapter 18. Citizen engagement: inclusive methodologies towards creating a city for all ages (Barbara Douglas) -- Chapter 19. Eleven study cases across Europe (Elisa Pozo Menéndez) -- Chapter 20. Learning and general principles for healthy and inclusive design considering regional context (Elisa Pozo Menéndez) -- Chapter 21. Conclusion and recommendations for further work (Elisa Pozo Menéndez).
    Abstract: This book represents a multidisciplinary and international vision across different countries in Europe that are facing similar challenges about ageing and quality of life in present cities. It is divided in three main topics from the global context of health in cities and reduction of health inequities to the current research of different study cases, focusing on residential models and the relationship with the built environment. The third chapter illustrates best practices with some study cases from different cities in Europe. Friendlier environments for older people come together with the need of innovation, smart and updated technologies, healthier environments and mitigation of climate change. Health re-appears nowadays as one of the priorities for urban planning and design, not only for the communicable diseases and the effect of the pandemics, but also for the non-communicable diseases, that were also triggering the wellbeing and equity of our cities. Indeed, the Covid-19 pandemic has highlighted health inequities and vulnerabilities of those areas of the city that were already deprived and facing other health problems, such as obesity, diabetes, social isolation, respiratory problems or mental health issues, specifically applying for vulnerable groups. Older adults have been one of the most affected groups from the pandemic’s threats and derived consequences. In this context, the care crisis arises intertwined with the design and planning of our cities, where there is an urgent need to regenerate our environments with a perspective of sustainability, inclusion, and health prevention and promotion. From the global urban challenges to the specific contextualisation of each city and study cases, each chapter offers an updated insight of the main questions that we should consider to address urban planning and design from the perspective of ageing and social inclusion in European cities.
    Type of Medium: Online Resource
    Pages: XXVIII, 469 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030938758
    Series Statement: Future City, 19
    DDC: 577.56
    Language: English
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  • 62
    Keywords: Environmental chemistry. ; Environmental health. ; Pollution. ; Environmental monitoring. ; Toxicology. ; Green chemistry. ; Environmental Chemistry. ; Environmental Health. ; Pollution. ; Environmental Monitoring. ; Toxicology. ; Green Chemistry.
    Description / Table of Contents: Chapter 1 Determination of Pesticide Residues in Fish -- Chapter 2 Analysis of Pesticide Residues in Pollen and Dairy Products -- Chapter 3 Monitoring and Evaluation of Pesticide Residues in Aquatic Systems -- Chapter 4 Pyrethroid and Residues in Chickens and Poultry Litter -- Chapter 5 Extraction Procedures and Chromatography of Pesticides Residues in Strawberries -- Chapter 6 Non-extractable Pesticide Residues in Soils -- Chapter 7 Pyrethroids Metabolites in Human Urine Samples -- Chapter 8 Remediation of Pesticide in Water -- Chapter 9 Strategy for the Inspection of Pesticide Residues in Food and Agriculture -- Chapter 10 Toxic Effects of Pesticides on Avifauna Inhabiting Wetlands -- Chapter 11 Analysis of Pesticide Residues in Biotic Matrices.
    Abstract: This book presents recent reviews on the occurrence, analysis, toxicity and remediation of pesticides in biological systems such as fish, chickens, water, soil and food.
    Type of Medium: Online Resource
    Pages: XV, 373 p. 96 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030547127
    Series Statement: Sustainable Agriculture Reviews, 47
    DDC: 577.14
    Language: English
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  • 63
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Life sciences. ; Cytology. ; Protein Biochemistry. ; Life Sciences. ; Cell Biology.
    Description / Table of Contents: Chapter 1. Structure, Dynamics and Function of the 26S Proteasome -- Chapter 2. Factor VIII and Factor V Membrane Bound Complexes -- Chapter 3. An Overview of DPS: Dual Acting Nanovehicles in Prokaryotes with DNA Binding and Ferroxidation Properties -- Chapter 4. Structure and Function of the Separase-Securin Complex -- Chapter 5. The DNA Replication Machine: Structure and Dynamic Function -- Chapter 6. Recent Progress in Structural Studies on the GT-C Superfamily of Protein Glycosyltransferases -- Chapter 7. How Structures of Complement Complexes Guide Therapeutic Design -- Chapter 8. Architecture and Assembly of the Bacterial Flagellar Motor Complex -- Chapter 9. Cellulosomes: Highly Efficient Cellulolytic Complexes -- Chapter 10. Leucine Dehydrogenase: Structure and Thermostability -- Chapter 11. Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3 -- Chapter 12. The SF3b Complex Is an Integral Component of the Spliceosome and Targeted by Natural Product-based Inhibitors -- Chapter 13. Interaction Networks of Ribosomal Expansion Segments in Kinetoplastids -- Chapter 14. Hepatitis B Core Protein Capsids -- Chapter 15. Fibrinogen and Fibrin -- Chapter 16. Structural Organization and Protein-protein Interactions in Human Adenovirus Capsid -- Chapter 17. A Structural Perspective on Gene Repression by Polycomb Repressive Complex 2 -- Chapter 18. Assembly and Function of the Anthrax Toxin Protein Translocation Complex.
    Abstract: This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License vialink.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 577 p. 166 illus., 157 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030589714
    Series Statement: Subcellular Biochemistry, 96
    DDC: 572.6
    Language: English
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  • 64
    Keywords: Plant ecology. ; Soil science. ; Conservation biology. ; Ecology . ; Agriculture. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Plant Ecology. ; Soil Science. ; Conservation Biology. ; Agriculture. ; Environmental Engineering/Biotechnology.
    Description / Table of Contents: Foreword -- Preface -- Chemical fertilizers and their impact on soil health -- Microbial Bioremediation of Pesticides/Herbicides in Soil -- Pollution cleaning up techniques -- Role of Mushrooms in the Bioremediation of Soil -- Microbial degradation of organic constituents for sustainable development -- Traditional farming practices and its consequences -- Soil organic matter and its impact on soil properties and nutrient status -- Sustainable Agricultural Practices -- Values of Composting -- Introduction to Microbiota and Biofertilizers -- Fungi and their potential as Biofertilizers -- Bacillus thuringiensis as a Biofertilizer and Plant Growth Promoter -- Cyanobacteria as Sustainable Microbiome for Agricultural Industries -- Intercropping: A Substitute but Identical of Biofertilizers -- Application of Phyllosphere Microbiota as Biofertilizers -- Biofertilizers: A Viable tool for future organic agriculture -- Index.
    Abstract: The dependence of present farming on artificial input of “chemical fertilizers” has caused numerous ecological tribulations associated with global warming and soil contamination. Moreover, there is an essential requirement for realistic agricultural practices on a comprehensive level. Accordingly, biofertilizers including microbes have been recommended as feasible environmentally sound solutions for agricultural practices which not only are natural, and cost-effective but also preserve soil environs and important biota of agricultural land. In addition, it enhances the nutrient quantity of soils organically. Microbial biofertilizers promote plant growth by escalating proficient absorption of nutrients for the plants and by providing an excellent disease-fighting mechanism. Agriculture, the backbone of human sustenance, has been put under tremendous pressure by the ever-increasing human population. Although various modern agro-techniques boosted agricultural production, the excessive use of synthetic fertilizers, pesticides and herbicides have proven extremely detrimental to agriculture as well as to the environment in which it is carried out. Besides this some faulty agricultural practices like monoculture and defective irrigation, further complicate the scenario by eliminating biodiversity, increasing the efflux of nutrients into the water bodies, the formation of algal blooms, eutrophication, damaging the water quality and lowering fish stocks. Biofertilizers are the organic compounds applied to crops for their sustainable growth and the sustainability of the environment as the microbiota associated with biofertilizers interact with the soil, roots and seeds to enhance soil fertility. Application of biofertilizers results in the increased mineral and water uptake, root development, vegetative growth and nitrogen fixation besides liberating growth-promoting substances and minerals that help the maintenance of soil fertility. They further act as antagonists and play a pivotal role in neutralising soil-borne plant pathogens and thus, help in the bio-control of diseases. Application of biofertilizers instead of synthetic fertilizers could be a promising technique to raise agricultural productivity without degrading environmental quality. The present book focuses on the latest research approaches and updates from the microbiota and their applications in the agriculture industry. We believe this book addresses various challenges and shed lights on the possible future of the sustainable agricultural system.
    Type of Medium: Online Resource
    Pages: XXVII, 350 p. 174 illus., 167 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030610104
    DDC: 581.7
    Language: English
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  • 65
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Ecology . ; Botany. ; Physical geography. ; Conservation biology. ; Ecology. ; Plant Science. ; Earth System Sciences. ; Conservation Biology.
    Description / Table of Contents: PRELIMINARY (ToC of second edition) 1 Plant ecology at high elevations -- The concept of limitation -- A regional and historical account -- The challenge of alpine plant research -- 2 The alpine life zone -- Altitudinal boundaries -- Global alpine land area -- Alpine plant diversity -- Origin of alpine floras -- Alpine growth forms -- 3 Alpine climate -- Which alpine climate -- Common features of alpine climates -- Regional features of alpine climates -- 4 The climate plants experience -- Interactions of relief, wind and sun -- How alpine plants influence their climate -- The geographic variation of alpine climate -- 5 Life under snow: protection and limitation -- Temperatures under snow -- Solar radiation under snow -- Gas concentrations under snow -- Plant responses to snowpack -- 6 Alpine soils -- Physics of alpine soil formation -- The organic compound -- The interaction of organic and inorganic compounds -- 7 Alpine treelines -- About trees and lines -- Current altitudinal positions of climatic treelines -- Treeline-climate relationships -- Intrazonal variations and pantropical plateauing of alpine treelines -- Treelines in the past -- Attempts at a functional explanation of treelines -- A hypothesis for treeline formation -- Growth trends near treelines -- Evidence for sink limitation -- 8 Climatic stress -- Survival of low temperature extremes -- Avoidance and tolerance of low temperature extremes -- Heat stress in alpine plants -- Ultraviolet radiation — a stress factor -- 9 Water relations -- Ecosystem water balance -- Soil moisture at high altitudes -- Plant water relations — a brief review of principles -- Water relations of alpine plants -- Desiccation stress -- Water relations of special plant types -- 10 Mineral nutrition -- Soil nutrients -- The nutrient status of alpine plants -- Nutrient cycling and nutrient budgets -- Nitrogen fixation -- Mycorrhiza -- Responses of vegetation to variable nutrient supply -- 11 Uptake and loss of carbon -- Photosynthetic capacity of alpine plants -- Photosynthetic responses to the environment -- Daily carbon gain of leaves -- The seasonal carbon gain of leaves -- C4 and CAM photosynthesis at high altitudes -- Tissue respiration of alpine plants -- Ecosystem carbon balance -- 12 Carbon investments -- Non-structural carbohydrates -- Lipids and energy content -- Carbon costs of leaves and roots -- Whole plant carbon allocation -- 13 Growth dynamics and phenology -- Seasonal growth -- Diurnal leaf extension -- Rates of plant dry matter accumulation -- Functional duration of leaves and roots -- 14 Cell division and tissue formation -- Cell size and plant size -- Mitosis and the cell cycle -- From meristem activity to growth control -- 15 Plant biomass production -- The structure of alpine plant canopies -- Primary productivity of alpine vegetation -- Plant dry matter pools -- Biomass losses through herbivores -- 16 Plant reproduction -- Flowering and pollination -- Seed development and seed size -- Germination -- Alpine seed banks and natural recruitment -- Clonal propagation -- Alpine plant age -- Community processes -- 17 Global change at high elevation -- Alpine land use -- The impact of altered atmospheric chemistry -- Climatic change and alpine ecosystems -- References (with chapter annotation) -- Taxonomic index (genera) -- Geographical index -- Color plates -- Plant life forms -- The alpine life zone -- Environmental stress -- The human dimension.
    Abstract: This book is a completely revised, substantially extended treatment of the physical and biological factors that drive life in high mountains. The book covers the characteristics of alpine plant life, alpine climate and soils, life under snow, stress tolerance, treeline ecology, plant water, carbon, and nutrient relations, plant growth and productivity, developmental processes, and two largely novel chapters on alpine plant reproduction and global change biology. The book explains why the topography driven exposure of plants to dramatic micro-climatic gradients over very short distances causes alpine biodiversity to be particularly robust against climatic change. Geographically, this book draws on examples from all parts of the world, including the tropics. This book is complemented with novel evidence and insight that emerged over the last 17 years of alpine plant research. The number of figures – mostly in color – nearly doubled, with many photographs providing a vivid impression of alpine plant life worldwide. Christian Körner was born in 1949 in Austria, received his academic education at the University of Innsbruck, and was full professor of Botany at the University of Basel from 1989 to 2014. As emeritus Professor he is continuing alpine plant research in the Swiss Alps.
    Type of Medium: Online Resource
    Pages: XIX, 500 p. 319 illus., 283 illus. in color. , online resource.
    Edition: 3rd ed. 2021.
    ISBN: 9783030595388
    DDC: 577
    Language: English
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  • 66
    Keywords: Agriculture. ; Veterinary medicine. ; Plant biotechnology. ; Vertebrates. ; Animal biotechnology. ; Agriculture. ; Veterinary Science. ; Plant Biotechnology. ; Vertebrate Zoology. ; Animal Biotechnology.
    Description / Table of Contents: The agriculture sector in Sub-Saharan Africa and the promise of biotechnology -- The state of capacities for agricultural biotechnology applications in the crop and livestock sectors -- The state of the enabling environment for agricultural biotechnology applications in the crop and livestock sectors -- The state of applications and impacts of biotechnology in the crop sector -- The state of applications and impacts of biotechnology in the livestock sector -- The state of capacities, enabling environment, applications and impacts of biotechnology in the forestry sector -- The state of capacities, enabling environment, applications and impacts of biotechnology in the aquaculture sector -- Overall status, gaps and opportunities in agricultural biotechnology in Sub-Saharan Africa. .
    Abstract: This book offers a comprehensive analysis of the application level for various agricultural biotechnologies across Sub-Saharan Africa. The authors examine the capacity available as well as the enabling environment, including policy and investments, for facilitating agricultural biotechnology development and use in the region. For each Sub-Saharan country, the status of biotechnology application is assessed in four major sectors; Crops, Livestock, Forestry and Aquaculture. Examples such as the number and requisite skill levels of trained personnel, biosafety frameworks and public awareness are surfaced in these chapters. This work also discusses the impact of push-pull factors on research, training and food security and identifies opportunities for investment in biotechnology and local agribusiness. Development partners, policy makers, agricultural consultants as well as scientists and private sector investors with an interest in biotechnology initiatives in Sub-Saharan Africa will find this collection an important account to identify key gaps in capacity and policy, as well as priority areas going forward. The volume highlights ways to develop technology and increase agricultural production capacity through international cooperation and inclusive economic growth, making it a valuable practice guide in line with the UN Sustainable Development Goals, in particular SDG 2 Zero Hunger and SDG 8 Decent Work and Economic Growth. Clear case studies round off the reading experience.
    Type of Medium: Online Resource
    Pages: XVII, 197 p. 16 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031043499
    DDC: 630
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Regenerative medicine. ; Biomedical engineering. ; Biomaterials. ; Biotechnology. ; Engineering design. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Engineering and Bioengineering. ; Biomaterials. ; Biotechnology. ; Engineering Design.
    Description / Table of Contents: Metallic and Ceramic Biomaterials: Current and Future Developments -- Polymers, Composites and Nano Biomaterials: Current and Future Developments -- Polyurethane Based Materials with Applications in Medical Devices -- Rapid Prototyping of Hydrogels to Guide Tissue Formation -- Engineered Scaffold Architecture Influences Soft Tissue Regeneration -- Customized Implants for Bone Replacement and Growth -- Direct Digital Manufacturing of Complex Dental Prostheses -- Digital Design and Fabrication in Dentistry -- The Development of an Artificial Finger Joint -- Computer-Aided Development of Mega Endo-Prostheses -- Smart Insoles -- Medical Applications of Additive Manufacturing -- Additive Manufacturing in Craniofacial Applications -- Additive Manufacturing in Hearing Aids.
    Abstract: This second edition maintains a focus on integrated biomaterials, computer-aided design, and physical prototyping techniques as examples of the materials and applications that are found in medical environments. All original chapters, written by renowned experts in the field, have been updated along with the addition of four new chapters on: Smart insoles Medical applications of additive manufacturing Additive manufacturing in craniofacial applications Additive manufacturing in hearing aids This wide-ranging treatise on biomaterials and prototyping applications in medicine also focuses on solid freeform fabrication, rapid prototyping, layered manufacturing, and computer-aided design in the development of prosthetic devices. This book is a must-have for bioengineers seeking a comprehensive overview of this important subject and examples of medical applications, as well as researchers and academics in the same field. .
    Type of Medium: Online Resource
    Pages: XII, 200 p. 104 illus., 60 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030358761
    DDC: 612.028
    Language: English
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  • 68
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Parasitology. ; Veterinary microbiology. ; Evolution (Biology). ; Biology Technique. ; Parasitology. ; Veterinary Microbiology. ; Evolutionary Theory. ; Experimental Organisms.
    Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: The zoonotic dog roundworm Toxocaracanis, a worldwide burden of public health -- Chapter 3: Canine leishmaniasis -- Chapter 4: The Challenges with Canine Giardia -- Chapter 5: Dogs and their role in the eco-epidemiology of Chagas disease -- Chapter 6: Echinococcus species – tiny tapeworms -- Chapter 7: An update on the status of hydatidosis/echinococcosis in domestic animals, wildlife and humans in Australia -- Chapter 8: Dipylidiumcaninum -- Chapter 9: Ancylostoma caninum and other canine hookworms -- Chapter 10: Strongyloidiasis - really a zoonosis? -- Chapter 11: Dirofilaria spp. Do they get under your skin (or into your heart)? -- Chapter 12: Guinea worm infection in dogs: a case of reverse zoonosis that impedes Dracunculusmedinensiseradication -- Chapter 13: Ticks, dogs and humans – an endangered community -- Chapter 14: Trematodes attacking dogs and humans.
    Abstract: This book presents the latest information on canine parasites with zoonotic potential, to help avoid human infections. Compiled by international specialists, it covers protozoa, ectoparasites and helminth species of clinical importance in dogs, as well as the state of the art in diagnosis, preventive measures and potentially necessary treatment schemes. Dogs are commonly kept in families around the world and can predispose their human companions to disease. Updating and deepening insights from other specialist literature, the book is intended for practitioners and scientists alike. It also offers practical guidance for veterinary and human physicians and highlights unexplored research areas, making it a valuable resource for students and educated non-experts with an interest in parasitology, infectiology and zoonotic pet diseases.
    Type of Medium: Online Resource
    Pages: IX, 291 p. 83 illus., 80 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030532307
    Series Statement: Parasitology Research Monographs, 13
    DDC: 571.999
    Language: English
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  • 69
    Keywords: Medical sciences. ; Neurology . ; Orthopedics. ; Pediatrics. ; Health Sciences. ; Neurology. ; Orthopaedics. ; Pediatrics.
    Description / Table of Contents: Chapter 1) Introduction -- Chapter 2) History of Neurosurgical Treatment for Spasticity -- Chapter 3) Anatomical Bases of Tone and Spasticity -- Chapter 4) Assessment of Spasticity in Adults -- Chapter 5) Decision-Making for Adults with Disabling Spasticity -- Chapter 6) Intrathecal Baclofen Therapy -- Chapter 7) Botulinum Toxin Injections for Spasticity -- Chapter 8) Peripheral Neurotomy -- Chapter 9) Surgery in the Dorsal Root Entry Zone -- Chapter 10) Spasticity and Hypertonia in Cerebral Palsy: Mechanisms and Surgical Implications -- Chapter 11) Assessment of Spasticity in Pediatric Patients -- Chapter 12) Decision-Making for Neurosurgical Treatment in Children with Disabling Spasticity -- Chapter 13) Dorsal Rhizotomy for Children with Cerebral Palsy -- Chapter 14) Neuro-Orthopedic Surgery for Correction of Spastic Disorders -- Chapter 15) Management of Neurogenic Overactive Bladder -- Chapter 16) Brief on Decision-Making for Neurosurgery of Spasticity in Adults and Children -- Chapter 17) Scales and Forms to Be Used in Practice.
    Abstract: The book, in its second edition, is devoted to the neurosurgical management of spasticity and focal dystonia. Starting with a chapter on the anatomical and physiological bases of spasticity and a short history of its neurosurgical treatment, it describes the neurosurgical methods currently available. As management differs between adults and children, the book is also structured accordingly, including evaluation, decision-making, Intrathecal Baclofen therapy (ITB), Botulinum toxin therapy and Surgery. The large spectrum of scales for assessing hypertonia, spasticity, dystonia, contracture and joint/bone deformities, as well as the scoring systems for quantifying functional abilities are critically reviewed. Beyond ITB, the neurosurgical options covered include the microsurgical procedures focusing on the peripheral nerves, dorsal roots, Dorsal Root Entry Zone and spinal cord, and their intra-operative monitoring. In this second edition, the orthopedic surgical interventions available will take a large place, either as alternative solutions , or even better as important complements after spasticity be solved by the neurosurgical treatments. Based on surgical experience collected with more than a thousand and eight-hundred patients, the book gathers the most important aspects of our present understanding, presented using a practical, educational approach. It stresses the importance of a multidisciplinary approach, including neurologists, pediatricians and rehabilitation specialists. Close collaborations with other surgical disciplines like orthopedic surgery and neuro-urology are outlined.
    Type of Medium: Online Resource
    Pages: XV, 359 p. 179 illus., 110 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030927172
    DDC: 610
    Language: English
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  • 70
    Keywords: Botany. ; Forestry. ; Botanical chemistry. ; Biotic communities. ; Plant genetics. ; Plant physiology. ; Plant Science. ; Forestry. ; Plant Biochemistry. ; Ecosystems. ; Plant Genetics. ; Plant Physiology.
    Description / Table of Contents: 1.Tools Shape Paradigms of Plant-Environment Interactions -- 2.Gene Expression in Coffee -- 3. Cross-Talk Between Sporophyte and Gametophyte During Anther and Ovule Development In Angiosperms -- 4. The Photosynthetic System in Tropical Plants Under High Irradiance and Temperature Stress -- 5. Plant Peroxisomes and Their Metabolism of ROS, RNS, and RSS -- 6. Ammonium Assimilation and Metabolism in Rice -- 7. How can we Interpret the Large Number and Diversity of Abscisic Acid Transporters? -- 8. Orient in the World with a Single Eye: The Green Algal Eyespot and Phototaxis -- 9. Bidirectional Lateral Transport Barriers in Serving Plant Organs and Integral Plant Functioning: Localized Lignification, Suberinization, and Cutinization -- 10. The Haustorium of Phytopathogenic Fungi: A Short Overview of a Specialized Cell of Obligate Biotrophic Plant Parasites -- 11. Transmission of Phloem-Limited Viruses in the Host Plants by Their Aphid Vectors -- 12. Biotechnology for Biofuel Production -- 13. Modelling Urban Tree Growth and Ecosystem Services: Review and Perspectives.
    Abstract: With one volume each year, this series keeps scientists and advanced students informed of the latest developments and results in all areas of the plant sciences. This latest volume includes reviews on plant physiology, biochemistry, genetics and genomics, forests, and ecosystems.
    Type of Medium: Online Resource
    Pages: XII, 464 p. 76 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030686208
    Series Statement: Progress in Botany, 82
    DDC: 580
    Language: English
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  • 71
    Keywords: Ecology . ; Botany. ; Zoology. ; Conservation biology. ; Ecology. ; Plant Science. ; Zoology. ; Conservation Biology.
    Description / Table of Contents: Part 1: Historical and biogeographical aspects -- The Atlantic Forest: an introduction to the megadiverse forest of Southern America -- The Atlantic Forest Ecological History: from pre-history to the Anthropocene -- The North-eastern Atlantic Forest: biogeographical, historical and current aspects in the Sugarcane Zone -- The Hileia Baiana - an assessment of natural and historical aspects of the land use and degradation of the central corridor of the Brazilian Atlantic Forest -- The southern Atlantic Forest: Use, degradation, and perspectives for conservation -- Part II – Biodiversity -- Tree diversity in the Brazilian Atlantic Forest: biases and general patterns using different sources of information -- Vascular Epiphytes of the Atlantic Forest: diversity and community ecology -- Social Insects of the Atlantic Forest -- Tetrapod diversity in the Atlantic Forest: maps and gaps -- Freshwater Studies in Atlantic Forest: general overview and prospects -- Part III – Threats -- Land-cover changes and an uncertain future: will the Brazilian Atlantic Forest lose the chance to become a hopespot? -- Climate change and biodiversity in the Atlantic Forest: best climatic models, predicted changes and impacts, and adaptation options -- Non-native species introductions, invasions, and biotic homogenization in the Atlantic Forest -- Causes and consequences of large-scale defaunation in the Atlantic forest -- Pollination systems in the Atlantic Forest: characterization, threats, and opportunities -- IV - Opportunities -- Atlantic Forest: ecosystem services linking people and biodiversity -- Changing the agriculture paradigm in the Brazilian Atlantic Forest: the importance of agroforestry -- Engaging people for large-scale forest restoration: Governance lessons from the Atlantic Forest of Brazil -- The Atlantic Forest Trail: connecting people, biodiversity and protected areas -- Conservation initiatives in the Brazilian Atlantic forest -- Financing conservation in the Brazilian Atlantic Forest -- Integrating researchers for understanding the biodiversity in Atlantic Forest -- The future of the Atlantic Forest.
    Abstract: The Atlantic Forest is one of the 36 hotspots for biodiversity conservation worldwide. It is a unique, large biome (more than 3000 km in latitude; 2500 in longitude), marked by high biodiversity, high degree of endemic species and, at the same time, extremely threatened. Approximately 70% of the Brazilian population lives in the area of this biome, which makes the conflict between biodiversity conservation and the sustainability of the human population a relevant issue. This book aims to cover: 1) the historical characterization and geographic variation of the biome; 2) the distribution of the diversity of some relevant taxa; 3) the main threats to biodiversity, and 4) possible opportunities to ensure the biodiversity conservation, and the economic and social sustainability. Also, it is hoped that this book can be useful for those involved in the development of public policies aimed at the conservation of this important global biome.
    Type of Medium: Online Resource
    Pages: XXX, 517 p. 66 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030553227
    DDC: 577
    Language: English
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  • 72
    Keywords: Botany. ; Plant genetics. ; Physiology. ; Plant Science. ; Plant Genetics. ; Physiology.
    Description / Table of Contents: Artificial Small RNAs for Functional Genomics in Plants -- Use of mRNA-interactome capture for generating novel insights into plant RNA biology -- Improving nutrient value of crops: Applications of RNAi in targeting plant metabolic pathways -- Utilizing RNA-based approaches to understand plant-insect interactions.
    Abstract: This book offers a unique and comprehensive overview of key RNA-based technologies, as well as their development and applications for the functional genomics of plant coding and non-coding genes. It focuses on the latest as well as classical RNA-based techniques used for studies on small RNAs, long non-coding RNAs and protein-coding genes. These techniques chiefly focus on target mimics (TMs) and short tandem target mimics (STTMs) for small RNAs, and artificial microRNAs (amiRNAs), RNA interference (RNAi) and CRISPR/Cas for genes. Furthermore, the book discusses the latest trends in the field and various modifications of the above-mentioned approaches, and explores how these RNA-based technologies have been developed, applied and validated as essential technologies in plant functional genomics. RNA-based technologies, their mechanisms of action, their advantages and disadvantages, and insights into the further development and applications of these technologies in plants are discussed. These techniques will enable the users to functionally characterize genes and small RNAs through silencing, overexpression and editing. Gathering contributions by globally respected experts, the book will appeal to students, teachers and scientists in academia and industry who are interested in horticulture, genetics, pathology, entomology, physiology, molecular genetics and breeding, in vitro culture & genetic engineering, and functional genomics. .
    Type of Medium: Online Resource
    Pages: XIII, 428 p. 48 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030649944
    Series Statement: Concepts and Strategies in Plant Sciences,
    DDC: 580
    Language: English
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  • 73
    Keywords: Biomedical engineering. ; Signal processing. ; Medical informatics. ; Radiology. ; Biomedical Engineering and Bioengineering. ; Signal, Speech and Image Processing . ; Health Informatics. ; Radiology. ; Biomedical Devices and Instrumentation.
    Description / Table of Contents: Chapter 1. Multi-CLASS fNIRS Classification of Motor Execution Tasks with Application to Brain Computer Interfaces -- Chapter 2. A Comparative Study of End-to-End Discriminative Deep Learning Models for Knee Joint Kinematic Time Series Classification -- Chapter 3. Nonlinear Smoothing of Data with Random Gaps and Outliers (DRAGO) Improves Estimation of Circadian Rhythm -- Chapter 4. Wearable Smart Garment Devices for Passive Biomedical Monitoring -- Chapter 5. Spatial Distribution of Seismocardiographic Signals -- Chapter 6. Noninvasive Vascular Blood Sound Monitoring Through Flexible Pvdf Microphone -- Chapter 7. Fast Automatic Artifact Annotator for EEG Signals Using Deep Learning -- Chapter 8. Objective evaluation metrics for automatic classification of EEG events.
    Abstract: This book provides an interdisciplinary look at emerging trends in signal processing and biomedicine found at the intersection of healthcare, engineering, and computer science. It examines the vital role signal processing plays in enabling a new generation of technology based on big data, and looks at applications ranging from medical electronics to data mining of electronic medical records. Topics covered include analysis of medical images, machine learning, biomedical nanosensors, wireless technologies, and instrumentation and electrical stimulation. Biomedical Signal Processing: Innovation and Applications presents tutorials and examples of successful applications, and will appeal to a wide range of professionals, researchers, and students interested in applications of signal processing, medicine, and biology. ·Presents an interdisciplinary look at research trends in signal processing and biomedicine; ·Promotes collaboration between healthcare practitioners and signal processing researchers; ·Includes tutorials and examples of successful applications.
    Type of Medium: Online Resource
    Pages: VIII, 261 p. 144 illus., 109 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030674946
    DDC: 610.28
    Language: English
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  • 74
    Keywords: Anatomy. ; Paleontology . ; Zoology. ; Evolution (Biology). ; Physiology. ; Mechanics. ; Anatomy. ; Paleontology. ; Zoology. ; Evolutionary Biology. ; Animal Physiology. ; Classical Mechanics.
    Description / Table of Contents: Chapter1: Why this book? -- Chapter2: Head -- Chapter3: Axial skeleton in aquatic animals -- Chapter4: Axial skeleton and muscle arrangement in terrestrial tetrapods -- Chapter5: What have the extremities of “lower tetrapods” in common? And Why? -- Chapter6: Birds -- Chapter7: Land-living mammals -- Chapter8: Primates, the group including humans -- Chapter9: Evolution of hominids -- Chapter10: Summary, Conclusions and Open questions.
    Abstract: This book discusses how and why animals evolved into particular shapes. The book identifies the physical laws which decide over the evolutionary (selective) value of body shape and morphological characters. Comparing the mechanical necessities with morphological details, the author attempts to understand how evolution works, and which sorts of limitations are set by selection. The book explains morphological traits in more biomechanical detail without getting lost in physics, or in methods. Most emphasis is placed on the proximate question, namely the identification of the mechanical stresses which must be sustained by the respective body parts, when they move the body or its parts against resistance. In the first part of the book the focus is on ‘primitive’ animals and later on the emphasis shifts to highly specialized mammals. Readers will learn more about living and fossil animals. A section of the book is dedicated to human evolution but not to produce another evolutionary tree, nor to refine a former one, but to contribute to answering the question: “WHY early humans have developed their particular body shape".
    Type of Medium: Online Resource
    Pages: XIV, 581 p. 222 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030276683
    DDC: 611
    Language: English
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  • 75
    Keywords: Medical sciences. ; Medical education. ; Health Sciences. ; Medical Education.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. What is Academia All About? Academic Career Roles and Responsibilities -- Chapter 3. Leveraging the Value of Diversity in the Academic Workforce -- Chapter 4. Integrating Community Service into Your Career Success -- Chapter 5. Realizing Your Leadership Potential -- Chapter 6. Building your Social Capital through Mentorship -- Chapter 7. The Scholarly Educator -- Chapter 8. Advancing Change through Discovery -- Chapter 9. Telling Your Story: Resume, CV, and Applications -- Chapter 10. The Profile of a Competitive Applicant.
    Abstract: This book increases undergraduate and graduate students' awareness of, interest in, and preparedness for academic health professions careers. It includes invaluable chapters that emphasize the importance of developing self-efficacy, knowledge, skills, and experiences not just for their resume but to build a foundation to strengthen students for the rest of their professional careers. The book provides the reader with basic information, tools, and a competitive edge through inspirational narratives from diverse graduate students and faculty, self-assessment exercises, and case-based discussion. These invaluable, authentic narratives will inspire, hearten, and encourage readers to pursue their health professional and academic careers confidently. Additionally, chapters outline the necessary tools for getting the most out of one's educational, research, service and leadership activities and optimize their competitiveness for graduate school and as pre-faculty. Unique, timely, and comprehensive, Health Professions and Academia provides undergraduate and graduate students with content to develop as competitive applicants to health-related graduate school and build a foundation from which they can establish successful careers in academia as future faculty, senior administrative leaders, and change agents.
    Type of Medium: Online Resource
    Pages: XI, 138 p. 53 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030942236
    DDC: 610
    Language: English
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  • 76
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Industrial microbiology. ; Cultural property Protection. ; Historic preservation. ; Biofilms. ; Microbial ecology. ; Industrial Microbiology. ; Conservation and Preservation. ; Biofilms. ; Environmental Microbiology.
    Description / Table of Contents: Chapter 1: Biodeterioration -- Chapter 2: Bioaerosol -- Chapter 3: Biocide -- Chapter 4: Biocleaning -- Chapter 5: Innovative and integrate strategies. Case studies -- Chapter 6: Taxidermal preparations of an extinct Sicilian wolf population (Canis lupus Linnaeus, 1758): Biological studies and Restoration.
    Abstract: This second fully updated and extended edition of Biotechnology and Conservation of Cultural Heritage provides in-depth insights into the role of different microorganisms and microbial compounds in biodeterioration, conservation and restoration of artworks and artifacts. Latest methods to detect, remove and prevent microbial colonization on artwork surfaces and in air environments of libraries and museums are discussed and illustrated by engaging case studies. Furthermore, this edition covers new case studies on Archaeobiology, exploring ways to perform the molecular biology characterization, restoring and protecting museum taxidermal specimens, preserving and guaranteeing the future integrity. Finally, the use of halloysite-nanotubes is investigated to set up innovative protocols in consolidation and long-term protection of waterlogged and archaeological wood. This book addresses to Biologists, Microbiologists, Conservation Scientists and Conservators who are interested in understanding the role of microorganisms and bioactive molecules in conservation projects. .
    Type of Medium: Online Resource
    Pages: XV, 132 p. 76 illus., 70 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030975852
    DDC: 660.62
    Language: English
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  • 77
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Epidemiology. ; Population genetics. ; Epidemiology. ; Population Genetics.
    Description / Table of Contents: Review of size estimation methods -- Methods to estimate the average social network size -- Estimating the size of hidden groups -- Data smoothing, extrapolation, and triangulation.
    Abstract: This book describes the variety of direct and indirect population size estimation (PSE) methods available along with their strengths and weaknesses. Direct estimation methods, such as enumeration and mapping, involve contact with members of hard-to-reach groups. Indirect methods have practical appeal because they require no contact with members of hard-to-reach groups. One indirect method in particular, network scale-up (NSU), has several strengths over other PSE methods: It can be applied at a province/country level, it can estimate size of several hard-to-reach population in a single study, and it is implemented with members of the general population rather than members of hard-to-reach groups. The book discusses methods to collect, analyze, and adjust results and presents methods to triangulate and finalize PSEs.
    Type of Medium: Online Resource
    Pages: VII, 72 p. 3 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030754648
    Series Statement: Advances in Experimental Medicine and Biology, 1333
    DDC: 614.4
    Language: English
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  • 78
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Nutrition   . ; Plant ecology. ; Soil science. ; Refuse and refuse disposal. ; Agriculture. ; Nutrition. ; Plant Ecology. ; Soil Science. ; Waste Management/Waste Technology.
    Description / Table of Contents: Chapter 1. Organic cultivation of vegetables -- Chapter 2. Reducing arsenic accumulation in rice using advances in physiology genetics and breeding -- Chapter 3. Speciation analysis of trace antimony in environmental and biological samples based on cloud point extraction and spectrometric methods -- Chapter 4. Groundwater status and challenges in Bangladesh -- Chapter 5. Influence of organic amendments on soil properties, microflora and plant growth -- Chapter 6. Basics of waste management and disposal practices in the Indian context -- Chapter 7. Impact of the invasive Prosopis juliflora on terrestrial ecosystems -- Chapter 8. Perennial forage grass production on the marginal Arabian Peninsula land -- Chapter 9. Agricultural sustainability and food security in agro-ecological zones of Tanzania -- Chapter 10. Soil degradation, resilience, restoration and sustainable use -- Chapter 11. Integrated weed management for sustainable agriculture -- Chapter 12. Electrical impedance spectroscopy in plant biology: theory, modeling and data processing -- Chapter 13. Non-symbiotic bacteria for soil nitrogen fortification -- Chapter 14. Nutritional and medical benefits of Moringa Oleifera, the miracle tree.
    Abstract: This book presents advanced knowledge and techniques to improve food quality, such as organic farming, fertilization using waste, reducing arsenic in food, soil restoration, forage production in arid regions and weed control. Agriculture is actually facing two major challenges, feeding an ever-growing population and providing safe food in the context of pollution, climate change and the future circular economy.
    Type of Medium: Online Resource
    Pages: VII, 460 p. 53 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030732455
    Series Statement: Sustainable Agriculture Reviews, 52
    DDC: 630
    Language: English
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  • 79
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology Technique. ; Medicine Research. ; Biology Research. ; Cancer. ; Radiology. ; Oncology. ; Cytological Techniques. ; Biomedical Research. ; Cancer Biology. ; Radiology. ; Oncology.
    Description / Table of Contents: 1. Current and Futuristic Roadmap of Ovarian Cancer Management: An Overview -- 2. Epithelial ovarian cancer and cancer stem cells -- 3. Ovarian Cancer: Therapeutic Strategies to Overcome Immune Suppression -- 4. Pharmacological effects of natural components against ovarian cancer and mechanisms -- 5. Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity -- 6. PAX8, an emerging player in Ovarian Cancer -- 7. Single Cell RNA Sequencing of Ovarian Cancer: Promises and Challenges.-8. Enforced expression of METCAM/MUC18 decreases in vitro motility and invasiveness and tumorigenesis and in vivo tumorigenesis of human ovarian cancer BG-1 cells -- 9. 3D Models for Ovarian Cancer -- 10. Ovarian Cancer Stem Cells: Characterization and Role in Tumorigenesis.
    Abstract: The present book on Molecular & Diagnostic Imaging and Treatment Strategies of ovarian cancer is one of two companion books with the second one being focused on Cell and Molecular Biology of Ovarian Cancer. Both books include new exciting aspects of ovarian cancer research with chapters written by experts in their respective fields who contributed their unique expertise in specific ovarian cancer research areas and include cell and molecular details that are important for the specific subtopics. Comprehensive and concise reviews are included of key topics in the field.
    Type of Medium: Online Resource
    Pages: VIII, 178 p. 43 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030733599
    Series Statement: Advances in Experimental Medicine and Biology, 1330
    DDC: 571.6028
    Language: English
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  • 80
    Keywords: Nervous system Surgery. ; Radiology. ; Biophysics. ; Nervous system Radiography. ; Neurology . ; Neurosciences. ; Neurosurgery. ; Radiology. ; Biophysics. ; Neuroradiology. ; Neurology. ; Neuroscience.
    Description / Table of Contents: Foreword -- Preface -- Introduction -- 1. Physics and radiation dosage issues in neuroradiosurgical treatment of meningiomas -- 2. Imaging Approaches for radiosurgical treatment of Meningiomas -- 3. MEDICAL MANAGEMENT OF MENINGIOMAS -- 4. Systemic Treatments for Grade II and III Meningiomas (WHO) -- 5. Gamma Knife Radiosurgery for Posterior Cranial Fossa Meningioma -- 6. Stereotactic Radiosurgery for Cavernous Sinus Meningiomas -- 7. Hypofractionated radiosurgery for perioptic meningiomas: Current practice, principles and treatment quandary -- 8. Hypofractionation and normofractionation in Skull Base Meningiomas -- 9. Atypical and anaplastic meningiomas: is there a role for stereotactic radiosurgery? -- 10. CyberKnife Treatment of Atypical Meningiomas (GII) -- 11. SRS & Microsurgery: antagonistic or complementary in the treatment of meningiomas? -- 12. Combined microsurgical and radiosurgical treatment in intracranial meningiomas -- 13. SRS in Incidental Meningioma: Whether to Treat and When -- 14. Side-effects of SRS treatment of low-grade meningioma: types, frequency and management -- 15. Single- and Multiple-Session Radiosurgery for Spinal Meningioma: Radiosurgery for spinal meningioma -- 16. Guidelines and evidence-based recommendations for the radiosurgical treatment of CNS meningiomas.
    Abstract: Meningiomas are the most frequently reported neuro-oncologic condition, accounting for 12% to 30% of all primary intracranial tumors. The first case of intracranial meningioma treated with stereotactic radiosurgery was reported by Backlund E-O in 1971. Since then, more than 200,000 meningiomas have been treated with stereotactic radiosurgery worldwide to date. The large number of patients treated using this method is due to the fact that meningiomas are frequently located in critical areas and microsurgery is often associated with severe and permanent neurological complications. This book discusses the advantages, risks and limits of stereotactic radiosurgery relating to all regions of interest for a neuroradiosurgical approach for the treatment of central nervous system meningiomas. Firstly, it presents an introduction focusing on the “state of the art”. It then discusses the physics, imaging, neurological and neuro-oncological issues in multidisciplinary management. Lastly, it features a summary of results, including the most recent published papers regarding all the locations involved in the stereotactic radiosurgery treatment as well as new approaches to meningiomas, with particular reference to the hypofrationated treatments. Intended for anyone involved in the neuroradiosurgical treatment of brain diseases, the book provides an up-to-date overview of the latest stereotactic radiosurgery treatment of central nervous system meningiomas.
    Type of Medium: Online Resource
    Pages: X, 160 p. 30 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030794194
    DDC: 617.48
    Language: English
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  • 81
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Ecology . ; Water. ; Hydrology. ; Plant Science. ; Ecology. ; Water. ; Water. ; Water.
    Description / Table of Contents: History of freshwater red algae; taxonomic diversity and phylogeny; biogeographic trends; how to collect freshwater red algae; scope and organization of this book -- Subphylum Cyanidiophytina: Class Cyanidiophyceae; Subphylum Proteorhodophytina: Classes Compsopogonophyceae, Porphyridiophyceae, Rhodellophyceae and Stylonematophyceae -- Subphylum Eurhodophytina: Classes Bangiophyceae and Florideophyceae (Subclasses Corallinophycidae, Hildenbrandiophycidae and Rhodymeniophycidae) -- Subphylum Eurhodophytina: Class Florideophyceae, Subclass Nemaliophycidae, Orders Acrochaetiales, Balbianiales and Thoreales -- Subphylum Eurhodophytina: Class Florideophyceae, Subclass Nemaliophycidae, Order Batrachospermales.
    Abstract: This book presents the phylogeny, taxonomy and biogeography of freshwater red algae. Its content is divided into five chapters. The first chapter provides a brief history of freshwater red algal research, habits and collecting methods, general biogeographic trends and an overview of the taxonomic/phylogenetic placement of freshwater taxa. The other four chapters are taxonomic treatments of non-marine red algae based on taxonomic levels, i.e. classes within the phylum Rhodophyta, orders within each class, families within each order, and genera within each family. Descriptions, phylogenetic data (including numerous trees), geographic range (maps for most species) and dichotomous keys for identification are presented. Comprehensive data are provided for more than 220 species.
    Type of Medium: Online Resource
    Pages: XII, 338 p. 113 illus., 112 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030839703
    DDC: 580
    Language: English
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  • 82
    Keywords: Nervous system Surgery. ; Neurology . ; Radiology. ; Neurosurgery. ; Neurology. ; Radiology.
    Description / Table of Contents: Evidence on Mechanical Thrombectomy in Acute Ischemic Stroke -- In Vitro Clot Modeling and Clinical Applications -- Approaches to Mechanical Thrombectomy in Children with Arterial Ischemic Stroke -- ELVO in Urban Areas: Evolution of Stroke Systems of Care -- Surviving Large Vessel Occlusions in Uruguay: Current Challenges and Solutions -- Direct to Angiography—An Emerging Paradigm in Large Vessel Occlusion Stroke: Rationale, Feasibility, and Preliminary Results -- Thrombectomy Techniques: Stent Retriever - Balloon Guide -- Direct Aspiration thrombectomy for acute stroke: Evolution of technique and evidence -- The Stentriever-Mediated Aspiration Thrombectomy (SMAT) Technique -- Transradial Approach for Stroke -- Thrombectomy Techniques: Remote Aspiration -- Endovascular Therapy for Middle Cerebral Artery Occlusions -- Thrombectomy for Basilar Occlusion: Approach and Strategy -- Carotid Terminus Occlusion -- Thrombectomy for Acute Occlusion in Intermediate-Sized Distal Arteries -- The Tandem Occlusion -- Acute Stroke Thrombectomy and Emergent Management of Tandem Cervical Dissections -- Acute Stroke Following Carotid Endarterectomy: Approach and Strategy -- Large vessel occlusion with underlying atherosclerosis: approach and strategy -- Large Vessel Occlusion with Low NIHSS: Approach and Strategy -- Challenges in Thrombectomy: Mega Clots -- Challenges in thrombectomy: Access Problems, Hard Clots, Relapsing Occlusions and Embolizaton to New Territories -- Challenges in Thrombectomy: Impossible Aortic Arches and Tortuous Vessels.
    Abstract: This comprehensive, case-based resource provides the state-of-the-art knowledge that can help readers improve access and optimize delivery of stroke thrombectomy. Improving access to stroke is of particular importance because patients often misinterpret their symptoms or cannot speak for themselves if they have aphasia. More importantly, access needs to be organized because stroke therapies are all extremely time-sensitive. Scalable, choreographed protocols are necessary for emergency medical systems to ‘capture’ stroke patients and automatically transport and triage to time-sensitive treatments. Many of the chapters in the first section on Fundamentals and Systems provide valuable insight in improving access to stroke care. Replete with illustrative case studies and emphasizing that treatment approaches to stroke should not be comprised of a one-size-fits-all approach, this illuminating title provides the complete thought, detail, insight and organization that will help readers meet the needs of stroke patients with large vessel occlusions. 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management examines the primary technical principles that underlie the current thrombectomy approaches. Instead of continuing the conceptual dichotomy of stent vs. aspiration, many of the chapters look at underlying principles and then discuss ways in which the currently available devices and approaches can best exploit them. The variety, creativity and detail in many of these chapters will help the reader develop a deeper understanding that might assist their ability to successfully take care of their next patient that ‘doesn’t follow the textbook.’ In addition, the anatomic and pathophysiologic classification of the core Twelve Chapters will help readers organize their thinking and approach. This knowledge, particularly because it is organized based on common, challenging syndromes, will arm the reader to quickly recognize patterns and deftly adapt their management approaches to the needs of the patient. An invaluable contribution to the clinical literature, 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management will be of great interest to not only neurosurgeons and neurologists but other specialists, primary care providers, and trainees as well. .
    Type of Medium: Online Resource
    Pages: XVII, 337 p. 115 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030568573
    DDC: 617.48
    Language: English
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  • 83
    Keywords: Agriculture. ; Human geography. ; Cultural geography. ; Anthropology. ; Demography. ; Population. ; Archaeology. ; Agriculture. ; Social and Cultural Geography. ; Anthropology. ; Population and Demography. ; Archaeology.
    Description / Table of Contents: Chapter1. Historical Demography -- Chapter2. Agricultural Landforms -- Chapter3. Cultural Plant Geography -- Chapter4. Human Environmental Impacts -- Chapter5. Indigenous Agro-Ecology -- Chapter6. Tropical Agriculture -- Chapter7. Livestock and Landscape -- Chapter 8. Synthetic Contributions -- Chapter9. By Way of Background: A Biographical Sketch of William M. Denevan -- Chapter10. Being a Student of Bill Denevan -- Chapter 11. Bill Denevan - An Appreciation -- .
    Abstract: This volume aims to present the essential work of geographer and historical ecologist William M. Denevan to explain the impact and influence his thinking had on the conceptual advancement not only in his own discipline, but in a range of related disciplines such as anthropology, archaeology, and environmental history. The book is organized around eight themes, demonstrating Denevan’s early and profound insights on topics that remain of current relevance today, and the scholarly impact his writing had on subsequent scholarship. The book is unique because it offers commentary from active scholars who address the impacts of Prof. Denevan's thinking and work on contemporary environmental and ecological issues, with a focus on several groundbreaking themes (e.g. historical demography, agricultural landforms, cultural plant geography, human environmental impacts, indigenous agro-ecology, tropical agriculture, livestock and landscape, and synthetic contributions). This book will be of interest to a range of scholars in geography, anthropology, archaeology, history, and ecology, as well as to environmental managers and practitioners, especially those working for non-profit organizations and government organizations tasked with finding ways to adapt to global environmental change. .
    Type of Medium: Online Resource
    Pages: XXII, 451 p. 62 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030424800
    DDC: 630
    Language: English
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  • 84
    Keywords: Biotechnology. ; Bioinformatics. ; Medical genetics. ; Biotechnology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1: Global Alignment of PPI Networks -- Chapter 2: Integrated Network-Based Computational Analysis for Drug Development -- Chapter 3: Effective Random Walk Models for Comparative Network Analysis -- Chapter 4: Computational Methods for Protein-Protein Interaction Network Alignment -- Chapter 5: Network Propagation for the Analysis of Multi_Omics Data -- Chapter 6: Motifs in Biological Networks -- Chapter 7: Bio Fabric Visualization of Network Alignments -- Chapter 8: Module Identification of Biological Networks via Graph Partition -- Chapter 9: Network Module Detection to Decipher the Heterogeneity of Cancer Mutations.
    Abstract: This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights. .
    Type of Medium: Online Resource
    Pages: XII, 217 p. 42 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571733
    DDC: 660.6
    Language: English
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  • 85
    Keywords: Neurosciences. ; Neurology . ; Medical genetics. ; Neuroscience. ; Neurology. ; Medical Genetics.
    Description / Table of Contents: 1. Behavioural variant FTD: recent advances in the diagnosis and understanding of the disorder -- 2. The neuropsychiatry of frontotemporal dementia -- 3. Nosology and Neuropathology of Language in Primary Progressive Aphasia -- 4. Measuring Behavior and Cognition in FTLD -- 5. Clinical update on C9orf72: FTD, ALS and beyond -- 6. Clinical aspects of familial FTLD associated with MAPT and GRN mutations -- 7. Neuroimaging in Frontotemporal Lobar Degeneration -- 8. The FTD Prevention Initiative - linking together genetic FTD cohort studies -- 9. Fluid Biomarkers of Frontotemporal Lobar Degeneration -- 10. Cross-cultural perspectives on frontotemporal degeneration -- 11. Clinical characteristics and Neuropathology of PSP, CBD and Related 4R-Tauopathies -- 12. Tau protein and frontotemporal dementias -- 13. FTLD-TDP pathological subtypes: clinical and mechanistic significance -- 14. Lysosomal dysfunction as a pathogenic mechanism in FTD: Evidence from PGRN and TMEM106B genetics and biology -- 15. Future trends in understanding the pathological role of TDP-43 and FUS proteins -- 16. Description of a new data resource for FTD including multiomic data on human post mortem brain (MAPT, GRN, C9orf72), matching mouse models and iPS models -- 17. Mendelian and sporadic FTD: avenues from genetics to disease pathways through in-silico prediction and modeling -- 18. FTLD treatment: Current Practice and Future Possibilities.
    Abstract: Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.
    Type of Medium: Online Resource
    Pages: X, 320 p. 46 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030511401
    Series Statement: Advances in Experimental Medicine and Biology, 1281
    DDC: 612.8
    Language: English
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  • 86
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Zoology. ; Biodiversity. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Ecology. ; Zoology. ; Biodiversity.
    Description / Table of Contents: Introduction: Christopher Clark and Ellen Garland -- Ch 1: Overview. Christopher Clark -- Ch. 2: Anatomy and physiology. Joy Reidenberg -- Ch. 3: Movement, Residency & Migration. Alex Zerbini and Sue Moore,- Ch. 4: Feeding strategies. Ari Friedlaender -- Ch. 5: Molecular genetics. Emma Carroll -- Ch. 6: Social organization. Peter Tyack -- Ch. 7: Ethological and bioacoustic variability. Christopher Clark -- Ch. 8: Baleen whale culture. Ellen Garland and Emma Carroll -- Ch. 9: Blue whale – Global diversity & behavioral variability in a specialist. Ana Sirovic -- Ch. 10: Humpback whale – Global diversity & behavioral plasticity in a court jester. Rebecca Dunlop -- Ch. 11: Humpback whale song - Global diversity & behavioral plasticity in a court jester. Danielle Cholewiak, Sal Cerchio and Ellen Garland -- Ch. 12: Bowhead whale – Acoustic variability in the almost-a-right whale that went north. Kate Stafford -- Ch. 13: Right whales - From north to south, what’s the big difference? Susan Parks -- Ch. 14: Minke Whale – Diversity and variability. Denise Risch -- Ch. 15: Omura’s Whale – An enigma. Sal Cerchio. .
    Abstract: In this book, an international team of leading marine mammal scientists, with a remarkably diverse set of backgrounds and areas of expertise, lead you through a synthesis of current knowledge on baleen whales. Baleen whales are the largest animals ever to have lived on this planet. They also have the lowest and most intense voices on Earth, most likely evolved to take advantage of ocean acoustic transmission conditions so as to be detectable across ocean basins. Some baleen whales can live to be 150-200 years old. They migrate many thousands of kilometers between feeding and breeding areas. They produce songs and calls that serve as behavioral foundations for establishing, maintaining and expanding their cultural identities. To conclude that we know the behavioral limits of these large brained, long-lived animals would be naïve. As baleen whale scientists, we are still beginning to comprehend the enormous complexities and natural histories of these remarkable animals. Today, the fact that whales sing is known throughout much of the world. This awareness started 50 years ago with the publication and popularization of a collection of humpback song recordings that motivated research into baleen whale behavioral ethology. In this book’s chapters, a reader’s experiences will stretch from learning about baleen whale laryngeal anatomy associated with their different voices to learning about the vast ocean areas over which their voices can be heard and the emerging complexities of their culturally defined societies. These are accompanied by chapters on the fundamental ethological contexts of socializing, migrating, and foraging. Two common themes permeate the book. One theme highlights the phenomenal increase in scientific knowledge achieved through technological advancements. The other theme recognizes the impacts of human-made activities on ocean acoustic environments and the resultant influences on the health and survival of individual whales and their populations. Although the book is intentionally ambitious in its scope, as scientists, we fully recognize that baleen whale science is still in its infancy. Many profound revelations await discovery by cohorts of young, multi-talented explorers, some of whom are stretching their wings in this volume and some of whom are reading these scientific stories for the first time.
    Type of Medium: Online Resource
    Pages: XVI, 384 p. 87 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030984496
    Series Statement: Ethology and Behavioral Ecology of Marine Mammals,
    DDC: 577.6
    Language: English
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  • 87
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical genetics. ; Medicine History. ; Life sciences. ; Biology Philosophy. ; Evolution (Biology). ; Biomaterials. ; Nucleic acids. ; Medical Genetics. ; History of Medicine. ; Life Sciences. ; Philosophy of Biology. ; Evolutionary Biology. ; Nucleic Acid.
    Description / Table of Contents: Abbreviations -- Prologue -- Part I. Genesis of a Geneticist -- 1 A Cambridge Childhood (1861-1882 -- 2 From Virginia to the Aral Sea (1883-1889) -- 3 Galton -- 4 Variation (1890-1894) -- 5 Romanes -- 6 Reorientation and Controversy (1895-1899) -- 7 What Life May Be -- Part II. Mendelism -- 8 Rediscovery (1900-1901) -- 9 Mendel’s Bulldog (1902-1906) -- 10 Bateson’s Bulldog -- 11 On Course (1907-1908) -- 12 Darwin Centenary (1909) -- 13 Chromosomes -- Part III. The Innes Years -- 14 Passages (1910-1914) -- 15 Eugenics -- 16 War (1915-1919) -- 17 My Respectful Homage (1920-1922) -- 18 Limits Undetermined (1923-1926) -- Part IV. Politics -- 19 Butler -- 20 Pilgrimages -- 21 Kammerer -- 22 Science and Chauvinism -- 23 Degrees for Women -- Part V. Eclipse -- 24 Bashing -- 25 Epilogue -- Part VI. Further Rediscovery -- 26 The Third Base -- 27 Mendel Basics -- 28 Romanes, Bateson, and Darwin's "Weak Point" -- 29 Bateson's Residue: Oligonucleotide Disharmony -- Publications of William Bateson -- References and Notes -- Acknowledgements -- Index.
    Abstract: William Bateson brought the work of Mendel (and much more) to the attention of the English-speaking world. He commanded the biological sciences in the decades after Darwin's death in 1882. To understand these years we must first understand Bateson. Through examination of the life of a major contributor to the turn-of-the-nineteenth-century revolution in biology, the authors reconcile the genocentrism of George Williams and Richard Dawkins with the hierarchical thinking of Richard Goldschmidt and Stephen Jay Gould. Aided by Rebecca Saunders, Bateson invented much of the basic terminology of modern genetics and, when addressing Darwin's great problem – the origin of species, introduced the mysterious term "the residue." While the first edition of this work (2008) related "residue" to relative concentrations of bases in DNA, the second edition reveals this as reflecting fundamental differences in short strings of bases. Thus, the book has come to represent not only Bateson’s science and life, but also a revised history of the biosciences that is likely to be increasingly visited, both by scientists and by those who wish to fully understand contemporary debates on racial, eugenic and gender aspects of genetics. In a nutshell, the book describes what we, in modern terms, would call a "colossal intelligence failure." Mendel handed it to us "on a plate" in 1865 when Bateson was only 4. It took 35 years to "join the dots" with Bateson a primary joiner. Shrugged off by many 20th century scientists as a freak "blip" in what was really an orderly advance, the Mendel episode was but one of a succession of such "blips." Thus, a multiplicity of post-Mendelian "Mendels" emerge as the story of Bateson's life unfolds. Peter Harper in Human Genetics (2009): "This book puts the record straight and one is left with a feeling of admiration for Bateson as both a scientist and a man, and with no doubt that he, more than anyone else, was largely responsible for the rapid progress in modern genetics during the first decade of the twentieth century." Michael J. Wade in Evolution (2009): "I strongly recommend this book for its information on an important central figure and for its bringing to life the several controversies at the origins of Genetics. It greatly illuminates the conceptual foundations of evolutionary genetics." Elof Axel Carlson in Quarterly Review of Biology (2009): "This volume will be of enormous benefit to historians of science who like to follow how ideas are born or die and why participants of different sides of each controversy held such rigid views of their own work and saw little merit in their competitor’s research." Joel S. Schwartz in Choice (2009): "This work includes key events in Bateson's career and is strengthened by discussion of the rediscovery of Mendelian principles by early 20th-century geneticists. Its basic premise is that Bateson was not merely one of the founders of genetics but played a pivotal role in the development of evolutionary biology by serving as the link between Victorian naturalists and early 20th-century biologists." Amitabh Joshi in Journal of Genetics (2010): "There is much in this book that I was not aware of, despite a formal training in genetics and a strong amateur interest in the history of biology.… It is certainly a book that any serious student of either genetics or evolution would greatly benefit from reading." .
    Type of Medium: Online Resource
    Pages: XXXIX, 688 p. 59 illus., 9 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030920999
    DDC: 616.042
    Language: English
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  • 88
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food science. ; Plant biotechnology. ; Consumer behavior. ; Food Science. ; Plant Biotechnology. ; Consumer Behavior .
    Description / Table of Contents: 1. Cereals in the Mediterranean: breeding history -- 2. The evolution of milling processing -- 3. Wheat bread in the Mediterranean area: from past to the future -- 4. Italian pasta: conventional and innovative ingredients and processing -- 5. From tradition to innovation in cereal-derived foodstuffs -- 6. Blending pulses with cereals for healthier foods -- 7. Snacking: ingredients, processing and safety -- 8. Rice: a versatile food at the heart of the Mediterranean diet -- 9. The Bright and Dark Sides of Wheat -- 10. Gluten-free breadmaking: facts, issues and future -- 11. The holy grail of ancient cereals -- 12. Safety of traditional cereals foodstuff. .
    Abstract: Cereal-Based Foodstuffs: The Backbone of the Mediterranean provides an overview of cereal-based products in the Mediterranean region, illustrating the spectrum of products from past to present and their various processing methods. The text explores new and understudied market trends in cereal-based products, such as cereal-pulse blends, pulse pastas, and flat breads. Chapters cover products originating in North Africa, such as bulgur and couscous, which are consumed worldwide but underrepresented in the scientific literature. Contributing authors also offer a legislative perspective on issues of food safety, the European Food Safety Association’s definition of “novel foods,” and the position of traditional foods in the Mediterranean food industry. This wide-ranging text thus serves members of both the scientific and industrial community seeking better coverage of global cereal product trends.
    Type of Medium: Online Resource
    Pages: VIII, 339 p. 100 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030692285
    DDC: 641.3
    Language: English
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  • 89
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Immunology. ; Rheumatology. ; Diseases. ; Hematology. ; Oncology. ; Primary care (Medicine). ; Immunology. ; Rheumatology. ; Diseases. ; Hematology. ; Oncology. ; Primary Care Medicine.
    Description / Table of Contents: Chapter 1. Overview of Immunodeficiency -- Part I. B-Lymphocyte Immunodeficiency -- Chapter 2. Common Variable Immunodeficiency, Hypogammaglobulinemia, and Specific Antibody Deficiency -- Chapter 3. Agammaglobulinemia -- Chapter 4. Class Switch Defects -- Chapter 5. Transient Immunodeficiency of Infancy -- Chapter 6. Selective Isotype Immunodeficiency -- Chapter 7. Common Variable Immunodeficiency Disorders-like Disorders -- Part II. T-Cell Immunodeficiency -- Chapter 8. Severe Combined Immunodeficiency -- Chapter 9. Idiopathic CD4 Lymphopenia -- Chapter 10. Hyper IgE Syndrome -- Chapter 11. Genetic Syndromes with Associated Immunodeficiencies -- Part III. Immune Dysregulation Syndromes -- Chapter 12. Autoimmune Lymphoproliferative Syndrome -- Chapter 13. Auto-inflammatory Syndromes -- Chapter 14. Immune Dysregulation Leading to Autoimmunity -- Chapter 15. Dendritic Cells in Primary Immunodeficiency -- Part IV. Innate Immune Defects -- Chapter 16. Congenital Neutropenia and Migration Defects -- Chapter 17. Chronic Granulomatous Disease -- Chapter 18. Primary Immunodeficiencies of Complement -- Chapter 19. Natural Killer Cell Defects -- Chapter 20. Mucocutaneous Candidiasis -- Part V. Secondary Immunodeficiency -- Chapter 21. Immunodeficiency Secondary to Malignancies and Biologics -- Chapter 22. Immunodeficiency Secondary to Prematurity, Pregnancy, and Aging -- Chapter 23. Vaccinations in Primary and Secondary Immunodeficiencies Including Asplenia.
    Abstract: This book provides a broad clinical overview of primary and secondary immunodeficiencies nested in clinical cases that will help the reader understand the approach to evaluation, diagnosis, and management of these challenging cases. Chapters begin with a comprehensive overview of immunodeficiencies to ground the reader in practical knowledge of the field and these complex conditions. Chapters cover B lymphocyte immunodeficiency, T cell immunodeficiency, immune dysregulation syndromes, and innate immune defects. They discuss a range of treatment options including gene therapy or bone marrow transplant. The book continues with a discussion on secondary immunodeficiencies and their treatment. Each chapter was written by authors with expertise related to different immunodeficiency disorders and provide a succinct overview of pathomechanisms, diagnosis, and treatment of a specific condition. Primary and Secondary Immunodeficiency will be an excellent resource for practicing allergists, hematologists, clinical immunologists, fellows, residents, and other clinicians who work with immunodeficiency patients.
    Type of Medium: Online Resource
    Pages: XI, 417 p. 34 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571573
    DDC: 571.96
    Language: English
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  • 90
    Keywords: Medical sciences. ; Pollution. ; Environmental chemistry. ; Refuse and refuse disposal. ; Health Sciences. ; Pollution. ; Environmental Chemistry. ; Waste Management/Waste Technology.
    Description / Table of Contents: Preface -- Chapter 1 Emerging Contaminants: Analysis, Aquatic Compartments and Water Pollution -- Chapter 2 Occurrence, Fate and Associated Risks of Organic Micropollutants included in the Watch List in the European Groundwater Bodies -- Chapter 3 Emergence of Pathogenic Fungi Resistant to Triazole Antifungal Drugs. A Threat from the Environment- Chapter 4 The Fate of Antibiotic-Resistant Bacteria in the Environment -- Chapter 5 Relationship Between Outdoor Ambient Air Pollution and Cardiovascular Disorders: A Narrative Review -- Index.
    Abstract: Emerging contaminants are chemical and biological agents for which there is growing concern about their potential health and environmental effects. The threat lies in the fact that the sources, fate and toxicology of most of these compounds have not yet been studied. Emerging contaminants, therefore, include a large number of both recently discovered and well-known compounds such as rare earth elements, viruses, bacteria, nanomaterials, microplastics, pharmaceuticals, endocrine disruptors, hormones, personal care products, cosmetics, pesticides, surfactants and industrial chemicals. Emerging contaminants have been found in many daily products, and some of them accumulate in the food chain. Correlations have been observed between aquatic pollution by emerging contaminants and discharges from wastewater treatment plants. Most actual remediation methods are not effective at removing emerging contaminants. This first volume presents comprehensive knowledge on emerging contaminants with a focus on analysis, toxicity, antibiotic resistance and human health.
    Type of Medium: Online Resource
    Pages: XVI, 308 p. 54 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030690793
    Series Statement: Environmental Chemistry for a Sustainable World, 65
    DDC: 610
    Language: English
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  • 91
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Plant anatomy. ; Plants Evolution. ; Plant ecology. ; Plant physiology. ; Plants Reproduction. ; Computational and Systems Biology. ; Plant Anatomy and Morphology. ; Plant Evolution. ; Plant Ecology. ; Plant Physiology. ; Plant Reproduction.
    Description / Table of Contents: Preface -- Acknowledgements -- Introduction: Collecting, Observing, and Describing the Natural World -- Scientific Ferment in late Eighteenth Century Edinburgh -- Scientific Exploration During Voyages of Discovery -- ... the plants of Scotland might be equally useful -- Travels in the Interior Districts of Africa -- A good practical Botanist -- So remote a country as New Holland -- The Crew labouring under the Same disorder -- Mungo Park's Last Journey -- A Tedious and Uncomfortable Passage -- Prodrommus, Florae Novae Hollndiae -- Banks's Librarian -- Taking leave of Sir Joseph Banks -- Pollen Grains of Clarkis pulchella -- Epilogue: The greatest of Banksian botanist-librarians -- Bibliography.
    Abstract: Explorer-naturalists Robert Brown and Mungo Park played a pivotal role in the development of natural history and exploration in the late eighteenth and early nineteenth centuries. This work is a fresh examination of the lives and careers of Brown and Park and their impact on natural history and exploration. Brown and Park were part of a group of intrepid naturalists who brought back some of the flora and fauna they encountered, drawings of what they observed, and most importantly, their ideas. The educated public back home was able to gain an understanding of the diversity in nature. This eventually led to the development of new ways of regarding the natural world and the eventual development of a coherent theory of organic evolution. This book considers these naturalists, Brown, Park, and their contemporaries, from the perspective of the Scottish Enlightenment. Brown’s investigations in natural history created a fertile environment for breakthroughs in taxonomy, cytology, and eventually evolution. Brown’s pioneering work in plant taxonomy allowed biologists to look at the animal and plant kingdoms differently. Park’s adventures stimulated significant discoveries in exploration. Brown and Park’s adventures formed a bridge to such journeys as Charles Darwin’s voyage on H.M.S. Beagle, which led to a revolution in biology and full explication of the theory of evolution.
    Type of Medium: Online Resource
    Pages: XIX, 217 p. 39 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030748593
    Series Statement: Memoirs of The New York Botanical Garden, 122
    DDC: 570.285
    Language: English
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  • 92
    Keywords: Agricultural biotechnology. ; Agriculture Economic aspects. ; Plant diseases. ; Stress (Physiology). ; Plants. ; Plant biotechnology. ; Agricultural Biotechnology. ; Agricultural Economics. ; Plant Pathology. ; Plant Stress Responses. ; Plant Biotechnology.
    Description / Table of Contents: Introduction -- The role of selenium in human nutrition -- Methods for determination of selenium in foodstuffs -- Selenium uptake by selected vegetable species after fortification of the growing substrate.-Selenium uptake by selected vegetable species after foliar application -- Changes of selenium content in edibilities during the processing.
    Abstract: Selenium plays a significant role in preventing certain types of cancer and cardiovascular diseases. The level of Selenium in the human body depends on its concentration in food. In turn, the content in vegetable crops is a function of the soil-plant system. There are many countries in the world with low Selenium content in the soil. The average daily human intake is thus limited through food chain. Analysis of Selenium status suggests that fortification of the soil substrate with Sodium Selenate, and foliar application to agricultural crops are both effective means of Selenium enrichment. Our intention for this publication is to present the possibilities of augmenting Selenium content by biofortification of soils and plants through differentiated nutrition. In the first part of the monograph, the results of Selenium supplementation in model vegetation experiments are presented. The next part of the monograph presents the results of foliar supplementation of Selenium in field conditions. This book is an outstanding reference source for plant breeders and researchers engaged in biofortification of horticulture crops. It is also beneficial to agricultural companies and other stakeholders.
    Type of Medium: Online Resource
    Pages: XIV, 155 p. 29 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030704865
    DDC: 630
    Language: English
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  • 93
    Keywords: Medicine Research. ; Biology Research. ; Nutrition   . ; Food science. ; Chemistry, Organic. ; Biomedical Research. ; Nutrition. ; Food Science. ; Organic Chemistry.
    Description / Table of Contents: Part I: An overview of cancer and its mechanisms -- 1-A brief overview of cancer, its mechanisms, and prevention methods -- 2-MECHANISMS INVOLVED IN CARCINOGENESIS -- Part II: Functional foods/nutraceuticals as chemo preventive agents -- 3-Tomato (lycopene and β-carotene) and cancer -- 4-Essential Oils from Aromatic Plants in cancer prevention and treatment -- 5-Bee propolis (caffeic acid phenethyl ester) against cancer -- 6-Brown Algae (Fucoxanthin) Against Cancer -- 7-Cruciferous vegetables (indole-3-carbinol, isothiocyanates) against cancer -- 8-Crustacea (carotenoids namely astaxanthins) against cancer -- 9-Curcuma and breast cancer: a focus on cell signaling pathways -- 10-FRUITS AND VEGETABLES IN CANCER -- 11-Garlic: Allyl Sulfur Compounds and Cancer Prevention -- 12-Ginger (gingerols and 6-shogaol) against cancer -- 13-Saffron (crocins) against cancer -- 14-OLIVE LEAF (OLEUROPEIN) AND ITS ROLE IN CANCER: THERAPEUTIC UPDATES -- 15-Honey against cancer -- 16-Soybeans and phytoestrogen rich foods (genistein, daidzein) against cancer -- 17-Tea (catechins including (-)-epigallocatechin-3-gallate) and cancer -- 18-Probiotics and Cancer -- Part III: The role of nutrients in the prevention of cancer -- 19-Vitamins (C, D and E) against cancer -- 20-Minerals (namely selenium) and cancer -- 21-Dietary fibers/beta-glucan and cancer -- 22-Omega-3 Polyunsaturated Fatty Acids and Cancer.
    Abstract: Today's consumers are looking for food products with health-promoting roles in addition to nutritional benefits. With current research showing that nutraceuticals and functional foods rich in specific bioactives may have chemopreventative effects, these products are increasingly popular. However, while much in the literature supports the health-promoting features of these foods, few texts focus on their bioactive agents and their mode of action in cancer signaling. Nutraceuticals and Cancer Signalling: Clinical Aspects and Mode of Action explains the link between nutraceuticals and cancer in terms of clinical trials and modes of action. This book gives an overview of common cancers and their mechanisms, and the most common functional foods and their bioactive components. Individual chapters focus on specific functional foods--including tomatoes, garlic, honey, tea, yoghurt, and many more--their prominent bioactive compounds, and their mode of action in cancer signaling and chemoprevention. Recent findings on cancer-prevention roles of different vitamins and minerals are also discussed. For food scientists, nutritionists, and pharmaceutical experts looking to understand how functional foods can play a role in fighting cancer, this text serves as a one-stop reference.
    Type of Medium: Online Resource
    Pages: IX, 652 p. 52 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030740351
    Series Statement: Food Bioactive Ingredients,
    DDC: 610.72
    Language: English
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  • 94
    Keywords: Medical microbiology. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Biotechnology. ; Medical Microbiology. ; Biomedical Research. ; Pharmacology. ; Biomedical Research. ; Biotechnology.
    Description / Table of Contents: 1.Introduction to Drugs, Drug Targets and Drug Resistance -- 2.Drugs Resistance in Bacterial Diseases -- 3.Drugs Resistance Against Viral Diseases -- 4.Drug Resistance in Protozoal Infections -- 5.Antifungal Drugs: Mechanism of Action and Resistance -- 6.Drug Resistance in Ear, Nose, and Throat Infections -- 7.Drug Resistance in Skin Diseases -- 8.Drugs Resistance in Lungs Diseases -- 9.Neurological Disorders: Biochemistry of Drug Resistance and Future Challenges -- 10.Drug Resistance in Kidney Diseases -- 11.Drugs resistance in Heart Diseases -- 12.Drugs Resistance in Liver Disease -- 13.Drug Resistance in Cancer -- 14.Drugs Resistance and Treatment Failure in HIV and / or AIDS -- 15.Drug Resistance in Reproductive Diseases -- 16.Drug Resistance in Diabetes -- 17.Drug Resistance in Rheumatological Diseases -- 18.Pherotypes in Streptococcus pneumoniae and Role of CSP-1 and CSP-2 in Antibiotic Susceptibility and Resistance; Towards Development of Live Attenuated Vaccine Candidates in Inducing Netosis Based Acquired Immune Response -- 19.Hypoxia, Obesity and Drug Resistance; Towards Sustainable Development Goals and Globalization -- 20.Genetic and Molecular Mechanisms of Multidrug-resistance in Uropathogens and Novel Therapeutic Combat -- 21.Drugs Resistance Management.
    Abstract: This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included. .
    Type of Medium: Online Resource
    Pages: XI, 558 p. 97 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030763206
    DDC: 616.9041
    Language: English
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  • 95
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Parasitology. ; Proteins . ; Molecular biology. ; Cytology. ; Tropical medicine. ; Parasitology. ; Protein Biochemistry. ; Molecular Biology. ; Cell Biology. ; Tropical Medicine.
    Description / Table of Contents: Chapter 1. Introductory Chapter: The Importance of Heat Shock Proteins in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum -- Chapter 2. General Structural and Functional Features of Molecular Chaperones -- Chapter 3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum -- Chapter 4. Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum. Chapter 5. Role of Hsp90 in Plasmodium falciparum Malaria -- Chapter 6. The Role of Malaria Parasite Heat Shock Proteins in Protein Trafficking and Remodelling of Red Blood Cells -- Chapter 7. Role of Heat Shock Proteins in Immune Modulation in Malaria -- Chapter 8. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalarial Drug Discovery? -- Chapter 9. Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery -- Chapter 10 -- Heat Shock Proteins of Malaria: Highlights and Future Prospects.
    Abstract: This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer’s Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.
    Type of Medium: Online Resource
    Pages: XIII, 251 p. 26 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030783976
    Series Statement: Advances in Experimental Medicine and Biology, 1340
    DDC: 571.999
    Language: English
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  • 96
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Food science. ; Environmental sciences Social aspects. ; Botany. ; Nutrition   . ; Agriculture. ; Food Science. ; Environmental Social Sciences. ; Plant Science. ; Nutrition.
    Description / Table of Contents: Ch 1: Introduction -- Ch 2: Physical and engineering properties of the seed -- Ch 3: Breeding and world production -- Ch 4: Functional food development and products -- Ch 5: Innovations in Bambara ground nut processing -- Ch 6: Composition and nutritional profile -- Ch 7: Ingredients and novel applications -- Ch 8: Food components and consumption trends -- Ch 9: Bambara ground nut as a climate smart crop -- Ch 10: Current and innovative packaging technologies for Bambara ground nut -- Ch 11 Integrating text mining and network analysis for potential application of Bambara ground nut -- Ch 12 Digitalization of Bambara food value -- Ch 13 Ethnonutrition and ethnomedical knowledge associated with Bambara ground nut -- Ch 14 Current and future research directions -- Ch 15 Conclusion -- Ch 16 References.
    Abstract: The Bambara groundnut (BGN) or Vigna subterranea is an extremely hardy grain legume. As it produces reasonable yields even under conditions of drought and low soil fertility, it is also a climate-smart crop. Previously underutilized, BGN is the subject of growing interest among researchers and consumers for its balanced nutritional profile. Indigenous consumers of BGN report medicinal benefits from the plant; however, such knowledge is at risk of being lost with the urbanization and changing lifestyles of younger generations. To date, there is no comprehensive resource on the Bambara groundnut, despite market demand for plant proteins around the globe. Authored by scientists who have researched and developed patents using BGN, Bambara Groundnut: Utilization and Future Prospects aims to fill this gap. The text provides in-depth coverage on breeding, food and feed utilization, medicinal benefits and future research prospects. Drawing on both indigenous knowledge and cutting-edge research, Bambara Groundnut is the first book to fully explore the potential of this remarkable crop.
    Type of Medium: Online Resource
    Pages: XVIII, 238 p. 65 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030760779
    DDC: 630
    Language: English
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  • 97
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Human physiology. ; Neurosciences. ; Pharmacology. ; Human Physiology. ; Neuroscience.
    Description / Table of Contents: Comparison of K+ Channel families -- High-resolution structures of K+ channels -- Pharmacological approaches to studying potassium channels -- Cardiac K+ channels and channelopathies -- Cardiac hERG K+ channel as safety and pharmacological target -- Pharmacology of A-type K+ channels -- Kv7 channels and hyperexcitability disorders -- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain -- Potassium channels in cancer -- Kir channel molecular physiology, pharmacology and therapeutic implications -- The pharmacology of ATP-sensitive K+ channels (KATP) -- Calcium-activated K+ channels (KCa) and therapeutic implications -- The Pharmacology of two-pore domain potassium channels -- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits -- Peptide toxins targeting KV channels -- Therapeutic antibodies targeting potassium ion channels.
    Abstract: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology. .
    Type of Medium: Online Resource
    Pages: VIII, 545 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030840525
    Series Statement: Handbook of Experimental Pharmacology, 267
    DDC: 615
    Language: English
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  • 98
    Keywords: Botany. ; Food science. ; Plant Science. ; Food Science.
    Description / Table of Contents: 1-Introduction to Opuntia spp.: Chemistry, bioactivity and Industrial Applications -- 2-South African perspective on Opuntia spp.: cultivation, human and livestock food and industrial applications -- 3-Ethnobotany, medicinal utilization and Systematics of Opuntia species from Deserts of Pakistan -- 4-Cactus Pear (Opuntia spp.) Species and Cultivars -- 5-Classification, Distribution and Morphological Characterization of Opuntia species -- 6-Cultivation and Cultural Practices of Opuntia spp -- 7-Molecular characterization of Opuntia spp -- 8-Genetic diversity and ecotypes of Opuntia spp -- 9-Potential attribute of crassulacean acid metabolism of Opuntia spp. production in water-limited conditions -- 10-Harvest and Postharvest Technology of Opuntia spp -- 11-Chemistry and functionality of Opuntia spp. nopal cladodes -- 12-Opuntia ficus-indica (L.) Mill. Bioactive Ingredients and Phyto-constituents -- 13-Opuntia Fiber and its Health-Related Beneficial Properties -- 14-Opuntia spp. chemical constituents and bioactive compounds, with particular regards to polyphenols -- 15-Profile and Biological Properties of the main Phenolic compounds in cactus pear (Opuntia spp.) -- 16-Opuntia spp. essential oils -- 17-Antioxidant activity of Opuntia spp.: A review -- 18-Natural antimicrobial molecules from Opuntia spp. and their role in poultry nutrition -- 19-Genus Opuntia: A golden source of compounds with anti-inflammatory potential -- 20-Opuntia spp. benefits in chronic diseases -- 21-Traceability of Opuntia spp -- 22-Antidiabetic Activity of Opuntia spp -- 23-Anticancer Activity of Opuntia spp -- 24-Innovative technologies for the identification of chemical and bioactive compounds in Opuntia spp. plant, food and waste -- 25-Innovation technologies for extracting Opuntia spp. seed oil -- 26-Novel pectins from prickly pear (Opuntia albicarpa) fruits: structural features and rheological properties -- 27-Modern Technologies in Opuntia spp. Juice Processing -- 28-Novel Technologies in Juice Processing from Opuntia spp. Fruits -- 29-Potential use of prickly pear juice prepared from shelf-grown cultivars as an authentic and nutritional fruit supplement -- 30-Fermented Beverages from Opuntia species: Composition, Commercialization and Future Outlook -- 31-Opuntia spp. Marmalade -- 32-Opuntia pear peel as a source of functional ingredients and their utilization in meat products -- 33-Opuntia spp. Seed Oil -- 34-Prickly pear (Opuntia ficus indica) processing by extrusion-cooking -- 35-Opuntia spp. and Extruded Food Products -- 36-Opuntia spp. Extruded Food Products -- 37-Industrial uses of Opuntia spp. by-products -- 38-Bread Enrichment with Opuntia spp. Derivatives -- 39-Opuntia spp. products and by-products as a potential source of edible films and coatings -- 40-Microencapsulation technology: an alternative preservation method for Opuntia spp. derived products and their bioactive compounds -- 41-Prickly pear (Opuntia spp.) in animal and poultry feed -- 42-Industrial applications of Opuntia spp. (nopal, fruit and peel) -- 43-Opuntia spp. as a source of sugars for the ethanol production -- 44-Opuntia spp. in biogas production -- 45-Opuntia spp. in dye-sensitized solar cells -- 46-Incorporation of Opuntia spp. into Food Systems -- 47-Opuntia spp. in cosmetics and pharmaceuticals -- 48-Food and non-food applications of Opuntia spp. seed oil -- 49-Opuntia spp. in the textile industry -- 50-Cactus pear as colorants and coloring foods: application in different food matrices.
    Abstract: The Opuntia fruits, commonly known as cactus pears or prickly pears, have been suggested by the Food and Agriculture Organization to be a promising and strategic crop in regions suffering from lack of water. In Mexico, India, South Africa, and the Mediterranean, the Opuntia fruits have become popular due to their nutritive value and health-promoting benefits, including antioxidant, antiulcerogenic and antiatherogenic traits and protective effects against LDL oxidation. Additionally, readily absorbable sugars, high vitamin C and mineral content, and a pleasant flavour make Opuntia tailor-made for novel food. Due to their ecological advantages, high functional value, and health-related traits, Opuntia fruits can be highly exploited in different food processing applications. For instance, Opuntia cactus fruits are used for the preparation of juices and marmalades; Opuntia cactus plants are used to feed animals in African and Latin American countries; Peruvian farmers cultivate Opuntia cactus for growing the cochineal (Dactylopius coccus) insect and producing the natural dye carmine; and the commercial production of food and non-food products from Opuntia has been established in Mexico, USA and several Mediterranean countries. Opuntia spp.: Chemistry, Bioactivity and Industrial Applications creates a multidisciplinary forum of discussion on Opuntia cactus with special emphasis on its horticulture, post-harvest, marketability, chemistry, functionality, health-promoting properties, technology and processing. The text includes detailed discussion of the impact of traditional and innovative processing on the recovery of high-added value compounds from Opuntia spp. by-products. Later chapters explore the potential applications of Opuntia spp. in food, cosmetics and pharmaceutical products.
    Type of Medium: Online Resource
    Pages: XIX, 1059 p. 98 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030784447
    DDC: 580
    Language: English
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  • 99
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food science. ; Chemistry, Organic. ; Food Science. ; Organic Chemistry.
    Description / Table of Contents: SECTION 1: CHEMISTRY OF PHENOLIC ANTIOXIDANTS -- Ch 1: Concept of Antioxidant -- Introduction to Antioxidant -- Types of antioxidants -- Mechanism of Antioxidant Reaction -- Estimation of Antioxidant Activity -- Phenolic Antioxidants -- Nomenclature of phenolic compounds -- Ch 2: Chemistry of Phenolic Antioxidants -- Classification -- Phenolic acids -- Phenolic aldehydes and alcohols -- Phenolic esters -- Cinnamic acid amides -- Lignans and lignin -- Tannins -- Coumarins -- Flavonoids -- Glycosides -- Ch 3: Phenolic Antioxidants in Foods -- Phenolic antioxidants in fruits -- Phenolic antioxidants in Vegetables -- Phenolic antioxidants in Cereals and legumes -- Phenolic antioxidants in Beverages -- Phenolic antioxidants in Edible Oil -- SECTION 2: BIOCHEMISTRY OF PHENOLIC ANTIOXIDANTS -- Ch 4: Biosynthesis of Phenolic Antioxidants -- Biosynthesis of Phenolic acids -- Biosynthesis of Phenolic aldehydes and alcohols -- Biosynthesis of Phenolic esters -- Biosynthesis of Cinnamic acid amides -- Biosynthesis of Lignans and lignin -- Biosynthesis of Tannins -- Biosynthesis of Coumarins -- Biosynthesis of Flavonoids -- Biosynthesis of Glycosides -- Ch 5: Metabolism of Phenolic Antioxidants. -- Ingestion of phenolic antioxidants -- Digestion and absorption -- Phenolic antioxidants in Bloodstream -- Interactions with Proteins -- Interactions with Carbohydrates -- Ch 6: Pharmacological Effects of Phenolic Antioxidants -- Pharmacological significance -- Oxidative stress & Phenolic antioxidants -- Aging & Phenolic antioxidants -- Health & Diseases -- Ch 7: Molecular Mechanism of Phenolic Antioxidants -- Basic Mechanism -- In-vitro studies -- In-vivo studies -- SECTION 3: ANALYSIS OF PHENOLIC ANTIOXIDANTS -- Ch 8: Basics in Analysis of Phenolic Antioxidants -- Extraction of phenolic compounds -- Spectrophotometric analysis -- Titrimetric methods -- Electrochemical methods -- Ch 9: Chromatography of Phenolic Antioxidants -- Thin layer chromatography -- Liquid chromatography -- Gas chromatography -- Ch 10: Spectroscopy of Phenolic Antioxidants -- Mass spectrometry -- Nuclear Magnetic resonance spectroscopy -- Near-infrared spectroscopy. .
    Abstract: Plant foods are an essential part of our daily diet and constitute one of the highest contributors to the world economy. These foods are rich in phenolic compounds, which play a significant role in maintaining our health. This textbook presents a comprehensive overview of the chemistry, biochemistry and analysis of phenolic compounds present in a variety of foods. The text can be used as a singular source of knowledge for plant food science and technology, covering all of the important chemical, biochemical and analytical aspects needed for a thorough understanding of phenolic antioxidants in foods. Phenolic Antioxidants In Foods: Chemistry, Biochemistry, and Analysis is comprised of three sections. The first section covers the basic concepts of antioxidants, their chemistry and their chemical composition in foods, providing a detailed introduction to the concept. The second section covers the biochemical aspects of phenolic antioxidants, including their biosynthetic pathways, biological effects and the molecular mechanism of antioxidant effects in the biological system. This section promotes an understanding of the fundamental biochemical reactions that take place in foods and after digestion and absorption. The third section covers the analytical chemistry used in the analysis of phenolic antioxidants in foods, including the basic analytical procedures, methods for analysis and chromatographic and spectroscopic analyses. This section is significant for aspiring food chemists and manufacturers to evaluate the nature and chemistry of phenolic antioxidants in foods. Featuring helpful quizzes, section summaries, and key chapter points, this textbook is the perfect learning tool for advanced chemistry undergraduates and post-graduates looking to gain a fundamental understanding of phenolic antioxidants in food products. .
    Type of Medium: Online Resource
    Pages: XIX, 556 p. 165 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030747688
    DDC: 641.3
    Language: English
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  • 100
    Keywords: Botany. ; Botanical chemistry. ; Food science. ; Medicine, Preventive. ; Health promotion. ; Agriculture. ; Plant Science. ; Plant Biochemistry. ; Food Science. ; Health Promotion and Disease Prevention. ; Agriculture.
    Description / Table of Contents: 1. Acrocomia aculeata -- 2. Attalea dubia & Attalea phalerata -- 3. Campomanesia genus -- 4. Caryocar spp -- 5. Mauritia flexuosa -- 6. Dipteryx alata -- 7. Solanum lycocarpum -- 8. Attalea speciosa -- 9. Syagrus romanzoffiana -- 10. Hancornia speciosa.
    Abstract: Fruits of the Brazilian Cerrado: Composition and Functional Benefits describes the nutritional, chemical and physical characteristics of the fruits of the Cerrado, as well as their pharmacological effects and use in phytotherapics. Chapters are dedicated to the morphological characteristics, macronutrients, micronutrients and active compounds of various fruits, with separate sections covering their peels, leaves, nuts, pulps, and other components. The text also includes detailed studies on the treatment of diseases with these natural products, as well as their applications in popular use by local communities. Authors explain the importance of bioactive compounds found in the fruits and their possible mechanisms of action in the organism. This text thus provides a valuable reference to researchers studying a range of topics, including functional foods, phytotherapy, and plant science.
    Type of Medium: Online Resource
    Pages: XIII, 186 p. 31 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030629496
    DDC: 580
    Language: English
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