ALBERT

Beschreibung: Axonal degeneration and neuronal cell death are fundamental processes in development and contribute to the pathology of neurological disease in adults. Both processes are regulated by BCL-2 family proteins which orchestrate the permeabilization of the mitochondrial outer membrane (MOM). MOM permeabilization (MOMP) results in the activation of pro-apoptotic molecules that commit neurons to either die or degenerate. With the success of small-molecule inhibitors targeting anti-apoptotic BCL-2 proteins for the treatment of lymphoma, we can now envision the use of inhibitors of apoptosis with exquisite selectivity for BCL-2 family protein regulation of neuronal apoptosis in the treatment of nervous system disease. Critical to this development is deciphering which subset of proteins is required for neuronal apoptosis and axon degeneration, and how these two different outcomes are separately regulated. Moreover, noncanonical BCL-2 family protein functions unrelated to the regulation of MOMP, including impacting necroptosis and other modes of cell death may reveal additional potential targets and/or confounders. This review highlights our current understanding of BCL-2 family mediated neuronal cell death and axon degeneration, while identifying future research questions to be resolved to enable regulating neuronal survival pharmacologically.

Beschreibung: The size–mass galaxy distribution is a key diagnostic for galaxy evolution. Massive compact galaxies are potential surviving relics of a high-redshift phase of star formation. Some of these could be nearly unresolved in Sloan Digital Sky Survey (SDSS) imaging and thus not included in galaxy samples. To overcome this, a sample was selected from the combination of SDSS and UKIRT Infrared Deep Sky Survey (UKIDSS) photometry to r 〈 17.8. This was done using colour–colour selection, and then by obtaining accurate photometric redshifts (photo-z) using scaled flux matching (SFM). Compared to spectroscopic redshifts (spec-z), SFM obtained a 1σ scatter of 0.0125 with only 0.3 per cent outliers (|Δln (1 + z)| 〉 0.06). A sample of 163 186 galaxies was obtained with 0.04 〈 z 〈 0.15 over $2300, { m deg}^2$ using a combination of spec-z and photo-z. Following Barro et al. log Σ1.5 = log M* − 1.5log r50, maj was used to define compactness. The spectroscopic completeness was 76 per cent for compact galaxies (log Σ1.5 〉 10.5) compared to 92 per cent for normal-sized galaxies. This difference is primarily attributed to SDSS ‘fibre collisions’ and not the completeness of the main galaxy sample selection. Using environmental overdensities, this confirms that compact quiescent galaxies are significantly more likely to be found in high-density environments compared to normal-sized galaxies. By comparison with a high-redshift sample from 3D-HST, log Σ1.5 distribution functions show significant evolution, with this being a compelling way to compare with simulations such as EAGLE. The number density of compact quiescent galaxies drops by a factor of about 30 from z ∼ 2 to log (n/Mpc−3) = − 5.3 ± 0.4 in the SDSS–UKIDSS sample. The uncertainty is dominated by the steep cut off in log Σ1.5, which is demonstrated conclusively using this complete sample.

Beschreibung: We present the spectrum analysis of the hot Am star HR 3383 (A1 Vm). Hubble Space Telescope STIS and Nordic Optical Telescope SOFIN data are modelled with synthetic spectra, and abundances are investigated for 78 elements. Most light elements up through oxygen show deficiencies, compared to solar abundances, followed by the general trend of increasing abundance enhancement with atomic number that levels off at a 30-fold enhancement at the lanthanide group and heavier elements. The derived element distribution is generally consistent with what is observed in other hot Am stars. Abundances for HR 3383 are also similar to what is seen for the cooler HgMn stars, with the exception of the platinum-group elements that generally show dramatic enhancements in the HgMn stars. Current theory and calculations are able to predict most observed abundances and abundance trends through the iron group. The large number of derived element abundances in this study provides a constraint for theoretical calculations attempting to explain the heavy element abundances in chemically peculiar stars. This paper includes a comprehensive description of spectral lines useful for an abundance analysis of late B and A type stars, and comments are provided on the atomic data. New data for hyperfine structure components for three lines in Lu iii and a single line in Lu ii are presented, based on laboratory spectra. In addition to the stellar spectrum, lines from the interstellar medium are noted for several of the strongest Fe ii ultraviolet transitions.

Beschreibung: We present correlations involving central intensity ratio (CIR) of 52 early-type galaxies, including 24 ellipticals and 28 lenticulars, selected from low-density environment in the nearby (

Beschreibung: In Pop III stellar models, convection-induced mixing between H- and He-rich burning layers can induce a burst of nuclear energy and thereby substantially alter the subsequent evolution and nucleosynthesis in the first massive stars. We investigate H–He shell and core interactions in 26 stellar evolution simulations with masses 15–140, M⊙, using five sets of mixing assumptions. In 22 cases H–He interactions induce local nuclear energy release in the range $sim 10^{9}!-!10^{13.5}, mathrm{L}_{odot }$. The luminosities on the upper end of this range amount to a substantial fraction of the layer’s internal energy over a convective advection time-scale, indicating a dynamic stellar response that would violate 1D stellar evolution modelling assumptions. We distinguish four types of H–He interactions depending on the evolutionary phase and convective stability of the He-rich material. H-burning conditions during H–He interactions give 12C/13C ratios between ≈ 1.5 to ∼1000 and [C/N] ratios from ≈ −2.3 to ≈ 3 with a correlation that agrees well with observations of CEMP (carbon-enhanced metal-poor) no stars. We also explore Ca production from hot CNO breakout and find the simulations presented here likely cannot explain the observed Ca abundance in the most Ca-poor CEMP-no star. We describe the evolution leading to H–He interactions, which occur during or shortly after core-contraction phases. Three simulations without an H–He interaction are computed to Fe-core infall and a $140, mathrm{M}_{odot }$ simulation becomes pair unstable. We also discuss present modelling limitations and the need for 3D hydrodynamic models to fully understand these stellar evolutionary phases.

Beschreibung: Massive galaxy clusters undergo strong evolution from z ∼ 1.6 to z ∼ 0.5, with overdense environments at high-z characterized by abundant dust-obscured star formation and stellar mass growth which rapidly give way to widespread quenching. Data spanning the near- to far-infrared (IR) can directly trace this transformation; however, such studies have largely been limited to the massive galaxy end of cluster populations. In this work, we present ‘total light’ stacking techniques spanning $3.4!-!500, mu$m aimed at revealing the total cluster emission, including low-mass members and potential intracluster dust. We detail our procedures for WISE, Spitzer, and Herschel imaging, including corrections to recover the total stacked emission in the case of high fractions of detected galaxies. We apply our techniques to 232 well-studied log$, M_{200}/mathrm{M}_{odot }sim 13.8$ clusters in multiple redshift bins, recovering extended cluster emission at all wavelengths. We measure the averaged IR radial profiles and spectral energy distributions (SEDs), quantifying the total stellar and dust content. The near-IR profiles are well described by an NFW model with a high (c ∼ 7) concentration. Dust emission is similarly concentrated, albeit suppressed at $rlesssim 0.3,$Mpc. The measured SEDs lack warm dust, consistent with the colder SEDs of low-mass galaxies. We derive total stellar masses consistent with the theoretical Mhalo−M⋆ relation and specific star formation rates that evolve strongly with redshift, echoing that of log$, M_{star }/mathrm{M}_{odot }gtrsim 10$ cluster galaxies. Separating out the massive population reveals the majority of cluster far-IR emission ($sim 70!-!80{{ m per cent}}$) is provided by the low-mass constituents, which differs from field galaxies. This effect may be a combination of mass-dependent quenching and excess dust in low-mass cluster galaxies.

Beschreibung: We provide an empirical list of the Galactic dispersion measure (DMGal) contribution to the extragalactic fast radio bursts (FRBs) along 72 sightlines. It is independent of any model of the Galaxy, i.e. we do not assume the density of the disc or the halo, spatial extent of the halo, baryonic mass content, or any such external constraints to measure DMGal. We use 21-cm, UV, EUV, and X-ray data to account for different phases, and find that DMGal is dominated by the hot phase probed by X-ray absorption. We improve upon the measurements of N($ m{O},{small VII}$) and f$_{ m O,{small VII}}$ compared to previous studies, thus providing a better estimate of the hot phase contribution. The median DMGal = 64$^{+20}_{-23}$ cm−3 pc, with a 68 per cent (90 per cent) confidence interval of 33–172 (23–660) cm−3 pc. The DMGal does not appear to follow any trend with the Galactic longitude or latitude, and there is a large scatter around the values predicted by simple disc + spherical halo models. Our measurements provide more complete and accurate estimates of DMGal independent from the previous studies. We provide a table and a code to retrieve DMGal for any FRB localized in the sky.

Beschreibung: The splashback radius (Rsp) of dark matter haloes has recently been detected using weak gravitational lensing and cross-correlations with galaxies. However, different methods have been used to measure Rsp and to assess the significance of its detection. In this paper, we use simulations to study the precision and accuracy to which we can detect the splashback radius with 3D density, 3D subhalo, and weak lensing profiles. We study how well various methods and tracers recover Rsp by comparing it with the value measured directly from particle dynamics. We show that estimates of Rsp from density and subhalo profiles correspond to different percentiles of the underlying Rsp distribution of particle orbits. At low accretion rates, a second caustic appears and can bias results. Finally, we show that upcoming lensing surveys may be able to constrain the Rsp–Γdyn relation directly.

Beschreibung: New Swift monitoring observations of the variable, radio-quiet quasar, PDS 456, are presented. A bright X-ray flare was captured in 2018 September, the flux increasing by a factor of 4 and with a doubling time-scale of 2 d. From the light crossing argument, the coronal size is inferred to be ≲30 gravitational radii for a black hole mass of 109 M⊙ and the total flare energy exceeds 1051 erg. A hardening of the X-ray emission accompanied the flare, with the photon index decreasing from Γ = 2.2 to Γ = 1.7 and back again. The flare is produced in the X-ray corona, the lack of any optical or UV variability being consistent with a constant accretion rate. Simultaneous XMM–Newton and NuSTAR observations were performed, 1–3 d after the flare peak and during the decline phase. These caught PDS 456 in a bright, bare state, where no disc wind absorption features are apparent. The hard X-ray spectrum shows a high energy roll-over, with an e-folding energy of $E_{ m fold}=51^{+11}_{-8}$ keV. The deduced coronal temperature, of kT = 13 keV, is one of the coolest measured in any AGN and PDS 456 lies well below the predicted pair annihilation line in X-ray corona. The spectral variability, becoming softer when fainter following the flare, is consistent with models of cooling X-ray coronae. Alternatively, an increase in a non-thermal component could contribute towards the hard X-ray flare spectrum.

Beschreibung: HD 38206 is an A0V star in the Columba association, hosting a debris disc first discovered by IRAS. Further observations by Spitzer and Herschel showed that the disc has two components, likely analogous to the asteroid and Kuiper belts of the Solar system. The young age of this star makes it a prime target for direct imaging planet searches. Possible planets in the system can be constrained using the debris disc. Here, we present the first ALMA observations of the system’s Kuiper belt and fit them using a forward modelling MCMC approach. We detect an extended disc of dust peaking at around 180 au with a width of 140 au. The disc is close to edge on and shows tentative signs of an asymmetry best fit by an eccentricity of $0.25^{+0.10}_{-0.09}$. We use the fitted parameters to determine limits on the masses of planets interior to the cold belt. We determine that a minimum of four planets are required, each with a minimum mass of 0.64 MJ, in order to clear the gap between the asteroid and Kuiper belts of the system. If we make the assumption that the outermost planet is responsible for the stirring of the disc, the location of its inner edge and the eccentricity of the disc, then we can more tightly predict its eccentricity, mass, and semimajor axis to be $e_{ m {p}}=0.34^{+0.20}_{-0.13}$, $m_{ m {p}}=0.7^{+0.5}_{-0.3}, m {it M}_{ m {J}}$, and $a_{ m {p}}=76^{+12}_{-13}, m {au}$.