Publication Date:
2017-07-13
Description:
Chromone derivatives have been extensively studied recently because of to their promising biological activities. The new title chromone–thiazole hybrid presented here, C14H10N2O3S, is a candidate as a selective ligand for adenosine receptors. The compound has been synthesized and characterized by the usual spectroscopic means (NMR and EM/IE) and its structure elucidated by X-ray crystallography, which revealed the presence of packing polymorphism. The two polymorphs (one with space group P21/n and one with P21/c) show slightly different conformations and the major change induced by crystallization regards the intramolecular contacts defining the supramolecular structure. Those differences been highlighted by Hirshfeld surface analysis mapped over dnorm and ESP.
Keywords:
crystal structuredrug designchromonesconformationsupramolecular structure
Electronic ISSN:
1600-5368
Topics:
Chemistry and Pharmacology
,
Geosciences
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