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  • Cell Biology  (16)
  • Development
  • American Association for the Advancement of Science (AAAS)  (21)
  • Elsevier
  • Institute of Physics
  • 2015-2019  (21)
  • 2016  (21)
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  • 2015-2019  (21)
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  • 1
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    [Editors' Choice] Activating Inflammation (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-07-01
    Description: Author: Stella M. Hurtley
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    [Perspective] Disrupted nuclear import-export in neurodegeneration (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-08-16
    Description: The major human neurodegenerative diseases, including Alzheimer's, amyotrophic lateral sclerosis, Parkinson's, and Huntington's diseases, are associated with accumulation and aggregation of misfolded proteins. In most cases, the majority of aberrantly aggregated proteins are found in the cell cytoplasm. However, in disorders caused by the expansion of a trinucleotide repeat, including Huntington's disease and spinocerebellar ataxia, the corresponding aggregates of proteins containing the encoded polyglutamine expansions are predominantly nuclear. Whether differences in intracellular location matter for the toxicity generated by such proteins has not been determined. On page 173 of this issue, Woerner et al. (1) report that the location does indeed matter, with toxicity arising from the cytoplasmic accumulation of a pair of artificial proteins designed to mimic the properties of amyloid aggregates. Surprisingly, forcing the same artificial proteins into the nucleus substantially reduces their toxicity. Authors: Sandrine Da Cruz, Don W. Cleveland
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    [This Week in Science] Altered fluid flow causes curved spine (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-06-10
    Description: Author: Beverly A. Purnell
    Keywords: Development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    [In Depth] CRISPR views of embryos and cells (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-06-03
    Description: Two teams have developed innovative new applications of the popular genome-editing method CRISPR. One of the groups has used it to mark and trace cells in a developing animal. In the method's first test, described online today in Science, the researchers reveal that many tissues and organs in adult zebrafish form from just a few embryonic cells. Other researchers are already looking to adapt the method to mice, or to exploit it to trace the evolution of tumors. The second group found a way to use CRISPR-guided mutations to record a cell's history—for example, the environmental signals that influence it. Author: Kai Kupferschmidt
    Keywords: Development
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    [Editors' Choice] Remodeling DNA by phases (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-06-10
    Description: Author: Guy Riddihough
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    [Editors' Choice] Microtubule sliding during Drosophila development (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-09-03
    Description: Author: Valda Vinson
    Keywords: Development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    [Editors' Choice] Slowing down to a standstill (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-05-13
    Description: Author: Stella M. Hurtley
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    [This Week in Science] Separating dividing cells into two (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-03-04
    Description: Author: Wei Wong
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    [This Week in Science] Stay on the right track (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-05-06
    Description: Author: Stella M. Hurtley
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    [Perspective] Formin' filaments at a faster CLIP (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-05-20
    Description: Cells of all kingdoms form a rigid but dynamic cytoskeleton that is essential for cell shape and growth. Microtubules and actin filaments build the eukaryotic cytoskeleton, and although they serve distinct functions, cooperation and indirect connections between these systems exist (1). On page 1004 of this issue, Henty-Ridilla et al. (2) report how a protein that accumulates at the growing tips of microtubules also elongates actin filaments, revealing an unexpected interaction between the two cytoskeletal systems. Author: Klemens Rottner
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    [Perspective] Nursing the oocyte (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-04-01
    Description: The generation of a mature egg, or oocyte, is essential for fertility. The oocyte requires the production of considerable quantities of messenger RNA (mRNA), protein, and organelles during its formation, a store needed for the subsequent development of the fertilized egg. In some species, these components are provided by neighboring cells called nurse cells (1). The role of nurse cells during oocyte development has been well studied in the fruit fly, Drosophila melanogaster, but it has been unclear if mammalian species also have nurse cells. On page 95 of this issue, Lei and Spradling (2) provide evidence for nurse cells during mouse oogenesis, adding to our understanding of mammalian oocyte development and raising hope for new infertility treatments. Author: Melissa E. Pepling
    Keywords: Development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    [Perspective] When cells push the envelope (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-04-15
    Description: By enclosing chromosomes within a nuclear envelope (NE), eukaryotic cells are able to segregate transcription and translation, key activities involved in gene expression (1). The implication is that maintenance of the NE as a selective barrier represents an essential aspect of normal cellular physiology. However, it also presents the cell with the predicament of how to accommodate a membrane-limited organelle that might occupy a substantial portion of the cell volume. On pages 353 and 359 of this issue, Denais et al. (2) and Raab et al. (3), respectively, report that the physical size and mechanical properties of the nucleus may have dramatic effects on the behavior of motile cells. Author: Brian Burke
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    [This Week in Science] Repairing tears in the nuclear envelope (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-04-15
    Description: Author: Stella M. Hurtley
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    [Perspective] Closing the loop (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-11-25
    Description: In 1963, the term autophagy was coined by Christian de Duve (Nobel Laureate, 1974) to denote the degradation of cellular self-constituents by the lysosome (1). In 2016, the Nobel Prize in Physiology or Medicine was awarded to Yoshinori Ohsumi for “his discoveries of mechanisms for autophagy” (2). Such discoveries led to the unveiling of autophagy as an evolutionarily conserved pathway that functions in differentiation and development, physiology, and protection against aging and many diseases (3). On page 1036 of this issue, Tsuboyama et al. (4) uncover a surprising twist to the mechanism in mammalian cells for forming the autophagosomal membrane, the structure that engulfs unwanted cellular cargo for delivery to the lysosome. These findings have implications for understanding the various roles of autophagy-related genes (ATGs) in membrane-trafficking and mammalian health and disease. Author: Beth Levine
    Keywords: Cell Biology
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    [Perspective] A finer look at a fine cellular meshwork (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-10-28
    Description: Students learning about the eukaryotic cell are taught that mitochondria are the powerhouse of the cell, the nucleus is the information storehouse, and lysosomes are the garbage disposal. Summing up the role of the endoplasmic reticulum (ER) is more problematic, even for professional cell biologists. Classically, the ER is where membrane proteins, secreted proteins, and most lipids are synthesized. It is also the site of calcium regulation. More recent work shows that it is the site of antigen presentation by major histocompatibility complex class I molecules, and the location of the unfolded protein response, now thought to be central to several major diseases. A new frontier is its relationships with other organelles (1). On page 433 of this issue, Nixon-Abell et al. (2) describe how an armamentarium of superresolution imaging techniques reveals new aspects of the ER's very heterogeneous morphology. Indeed, the “form follows function” adage may help to make sense of this organelle's functional issues. Author: Mark Terasaki
    Keywords: Cell Biology
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  • 16
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    [Editors' Choice] Microtubule repair and rescue (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-11-04
    Description: Authors: SH, Stella M. Hurtley
    Keywords: Cell Biology
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    [This Week in Science] Mitochondria migration during mitosis (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-08-16
    Description: Author: L. Bryan Ray
    Keywords: Cell Biology
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    [Editors' Choice] Crawling cells need to explore (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-12-16
    Description: Author: Sarah Harrison
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    [This Week in Science] A new paradigm for IP3 signaling (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-11-11
    Description: Author: Nancy R. Gough
    Keywords: Cell Biology
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    [Perspective] Apes know what others believe (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-10-08
    Description: Of all the human uniqueness claims proposed over the years, theory of mind enjoys perhaps the most prominent status. The term “theory of mind” refers to the ability to know what others know, that is, to attribute mental states such as intentions, goals, and knowledge to others. It is widely held to be unique to humans. Yet, given the results reported by Krupenye et al. on page 110 of this issue, this claim is starting to wobble (1). The authors show that apes can correctly anticipate where human actors will look for a hidden item, even if the apes know that the item is no longer there. Ironically, this finding brings us back to square one, because apes played a major role in the formulation of the theory of mind concept. Author: Frans B. M. de Waal
    Keywords: Development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    [In Depth] Nobel honors discoveries in how cells eat themselves (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-10-08
    Description: As the stench of the streets during a garbage strike quickly drives home, sanitation workers are the unsung heroes of modern cities and towns. Similarly, the cell's garbage collectors are key to health. By performing "autophagy"—literally, self-eating—they degrade or recycle toxic protein aggregates and cell components. This week, the cell biologist who worked out the genetics and mechanics of this process received the 2016 Nobel Prize in Physiology or Medicine. When Yoshinori Ohsumi, now at the Tokyo Institute of Technology's Frontier Research Center, did his pioneering work in yeast in the early 1990s, his results drew little attention outside cell biology. But in the past 15 years, others have shown that cells' clean-up machinery is crucial to human health. Authors: Martin Enserink, Elizabeth Pennisi
    Keywords: Cell Biology
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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