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  • Animals  (809)
  • Nature Publishing Group (NPG)  (809)
  • 2010-2014  (809)
  • 1950-1954
  • 2012  (809)
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  • 2010-2014  (809)
  • 1950-1954
Year
  • 1
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    Death-rate row blurs mutant flu debate (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-02-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- England -- Nature. 2012 Feb 13;482(7385):289. doi: 10.1038/482289a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22337028" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/analysis/immunology ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/immunology/isolation & ; purification/*pathogenicity ; Influenza, Human/epidemiology/immunology/*mortality/virology ; Models, Biological ; Poultry/virology ; Seroepidemiologic Studies ; Zoonoses/epidemiology/transmission/virology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Myocardial infarction accelerates atherosclerosis (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-07-06
    Description: During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaques in the arterial wall and cause their rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a high risk of recurrent events for unknown reasons. Here we show that the systemic response to ischaemic injury aggravates chronic atherosclerosis. After myocardial infarction or stroke, Apoe-/- mice developed larger atherosclerotic lesions with a more advanced morphology. This disease acceleration persisted over many weeks and was associated with markedly increased monocyte recruitment. Seeking the source of surplus monocytes in plaques, we found that myocardial infarction liberated haematopoietic stem and progenitor cells from bone marrow niches via sympathetic nervous system signalling. The progenitors then seeded the spleen, yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401326/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401326/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dutta, Partha -- Courties, Gabriel -- Wei, Ying -- Leuschner, Florian -- Gorbatov, Rostic -- Robbins, Clinton S -- Iwamoto, Yoshiko -- Thompson, Brian -- Carlson, Alicia L -- Heidt, Timo -- Majmudar, Maulik D -- Lasitschka, Felix -- Etzrodt, Martin -- Waterman, Peter -- Waring, Michael T -- Chicoine, Adam T -- van der Laan, Anja M -- Niessen, Hans W M -- Piek, Jan J -- Rubin, Barry B -- Butany, Jagdish -- Stone, James R -- Katus, Hugo A -- Murphy, Sabina A -- Morrow, David A -- Sabatine, Marc S -- Vinegoni, Claudio -- Moskowitz, Michael A -- Pittet, Mikael J -- Libby, Peter -- Lin, Charles P -- Swirski, Filip K -- Weissleder, Ralph -- Nahrendorf, Matthias -- P50-CA086355/CA/NCI NIH HHS/ -- R01 AI084880/AI/NIAID NIH HHS/ -- R01 EB006432/EB/NIBIB NIH HHS/ -- R01 HL095612/HL/NHLBI NIH HHS/ -- R01 HL095629/HL/NHLBI NIH HHS/ -- R01 HL096576/HL/NHLBI NIH HHS/ -- R01-EB006432/EB/NIBIB NIH HHS/ -- R01-HL095629/HL/NHLBI NIH HHS/ -- R01-HL096576/HL/NHLBI NIH HHS/ -- T32 CA079443/CA/NCI NIH HHS/ -- T32-CA79443/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Jul 19;487(7407):325-9. doi: 10.1038/nature11260.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22763456" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apolipoproteins E/genetics ; Atherosclerosis/*etiology/*pathology ; Hematopoietic Stem Cells/cytology ; Inflammation/complications ; Mice ; Mice, Inbred C57BL ; Monocytes/cytology ; Myocardial Infarction/*complications/*pathology ; Spleen/cytology ; Stem Cells/cytology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
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    Biodiversity: Think big for marine conservation (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weaver, Phil -- Johnson, David -- England -- Nature. 2012 Mar 21;483(7390):399. doi: 10.1038/483399a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Oceanography Centre, Southampton, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22437593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; *Biodiversity ; Conservation of Natural Resources/*methods ; Ecology/*methods ; Fishes ; Marine Biology/*methods ; Wilderness
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 4
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    Lab flu may not aid vaccines (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-02-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- England -- Nature. 2012 Feb 8;482(7384):142-3. doi: 10.1038/482142a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22318581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; *Influenza Vaccines/economics/immunology/supply & distribution ; Influenza, Human/*epidemiology/prevention & control/transmission/virology ; Laboratories ; Mutagenesis ; Pandemics/*prevention & control ; Time Factors ; Zoonoses/epidemiology/*transmission/*virology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-07-06
    Description: Members of the intracellular nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family contribute to immune responses through activation of nuclear factor-kappaB (NF-kappaB), type I interferon and inflammasome signalling. Mice lacking the NLR family member NLRP6 were recently shown to be susceptible to colitis and colorectal tumorigenesis, but the role of NLRP6 in microbial infections and the nature of the inflammatory signalling pathways regulated by NLRP6 remain unclear. Here we show that Nlrp6-deficient mice are highly resistant to infection with the bacterial pathogens Listeria monocytogenes, Salmonella typhimurium and Escherichia coli. Infected Nlrp6-deficient mice had increased numbers of monocytes and neutrophils in circulation, and NLRP6 signalling in both haematopoietic and radioresistant cells contributed to increased susceptibility. Nlrp6 deficiency enhanced activation of mitogen-activated protein kinase (MAPK) and the canonical NF-kappaB pathway after Toll-like receptor ligation, but not cytosolic NOD1/2 ligation, in vitro. Consequently, infected Nlrp6-deficient cells produced increased levels of NF-kappaB- and MAPK-dependent cytokines and chemokines. Thus, our results reveal NLRP6 as a negative regulator of inflammatory signalling, and demonstrate a role for this NLR in impeding clearance of both Gram-positive and -negative bacterial pathogens.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422416/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422416/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anand, Paras K -- Malireddi, R K Subbarao -- Lukens, John R -- Vogel, Peter -- Bertin, John -- Lamkanfi, Mohamed -- Kanneganti, Thirumala-Devi -- AI101935/AI/NIAID NIH HHS/ -- AR056296/AR/NIAMS NIH HHS/ -- R01 AI101935/AI/NIAID NIH HHS/ -- R01 AR056296/AR/NIAMS NIH HHS/ -- England -- Nature. 2012 Aug 16;488(7411):389-93. doi: 10.1038/nature11250.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22763455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Susceptibility/immunology ; Escherichia coli/*immunology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Immunity, Innate/*immunology ; Listeria monocytogenes/*immunology ; MAP Kinase Signaling System ; Mice ; Monocytes/cytology/enzymology/immunology/metabolism ; NF-kappa B/metabolism ; Neutrophils/cytology/enzymology/immunology/metabolism ; Receptors, Cell Surface/deficiency/genetics/immunology/*metabolism ; Salmonella typhimurium/*immunology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
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    EU agencies accused of conflicts of interest (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-05-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- England -- Nature. 2012 May 15;485(7398):294-5. doi: 10.1038/485294a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22596132" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Conflict of Interest ; Europe ; *European Union ; Food Safety ; Government Agencies/*ethics/organization & administration ; Humans ; Policy Making
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 7
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    Australia: small steps to control invasives (2012)
    Nature Publishing Group (NPG)
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    Publication Date: 2012-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Webber, Bruce L -- Scott, John K -- Didham, Raphael K -- England -- Nature. 2012 Feb 22;482(7386):471. doi: 10.1038/482471c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22358828" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conservation of Natural Resources/*methods ; Elephants/*physiology ; Fires/*prevention & control ; *Food Chain
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
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    A transcriptomic hourglass in plant embryogenesis (2012)
    Nature Publishing Group (NPG)
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    Publication Date: 2012-09-07
    Description: Animal and plant development starts with a constituting phase called embryogenesis, which evolved independently in both lineages. Comparative anatomy of vertebrate development--based on the Meckel-Serres law and von Baer's laws of embryology from the early nineteenth century--shows that embryos from various taxa appear different in early stages, converge to a similar form during mid-embryogenesis, and again diverge in later stages. This morphogenetic series is known as the embryonic 'hourglass', and its bottleneck of high conservation in mid-embryogenesis is referred to as the phylotypic stage. Recent analyses in zebrafish and Drosophila embryos provided convincing molecular support for the hourglass model, because during the phylotypic stage the transcriptome was dominated by ancient genes and global gene expression profiles were reported to be most conserved. Although extensively explored in animals, an embryonic hourglass has not been reported in plants, which represent the second major kingdom in the tree of life that evolved embryogenesis. Here we provide phylotranscriptomic evidence for a molecular embryonic hourglass in Arabidopsis thaliana, using two complementary approaches. This is particularly significant because the possible absence of an hourglass based on morphological features in plants suggests that morphological and molecular patterns might be uncoupled. Together with the reported developmental hourglass patterns in animals, these findings indicate convergent evolution of the molecular hourglass and a conserved logic of embryogenesis across kingdoms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Quint, Marcel -- Drost, Hajk-Georg -- Gabel, Alexander -- Ullrich, Kristian Karsten -- Bonn, Markus -- Grosse, Ivo -- England -- Nature. 2012 Oct 4;490(7418):98-101. doi: 10.1038/nature11394. Epub 2012 Sep 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Leibniz Institute of Plant Biochemistry, Department of Molecular Signal Processing, Weinberg 3, 06120 Halle (Saale), Germany. mquint@ipb-halle.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22951968" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arabidopsis/classification/*embryology/*genetics ; Brassicaceae/genetics ; Conserved Sequence/genetics ; Developmental Biology ; Drosophila/embryology/genetics ; Embryonic Development/genetics ; Evolution, Molecular ; Gene Expression Profiling ; Gene Expression Regulation, Plant/*genetics ; Genes, Plant/genetics ; Models, Biological ; Plant Development/*genetics ; Transcriptome/*genetics ; Zebrafish/embryology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
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    Turning point: Jessica Ware. Interviewed by Virginia Gewin (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ware, Jessica -- England -- Nature. 2012 Apr 5;484(7392):133.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22486001" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Career Mobility ; *Classification ; Cooperative Behavior ; Financing, Organized ; Fossils ; Genome/genetics ; *Genomics/history ; History, 21st Century ; *Insects/anatomy & histology/genetics/physiology ; *Social Behavior ; Transcriptome/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
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    Translational medicine: Mice and men show the way (2012)
    Nature Publishing Group (NPG)
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    Publication Date: 2012-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anagnostou, Evdokia -- England -- Nature. 2012 Nov 8;491(7423):196-7. doi: 10.1038/491196a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23135462" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Autistic Disorder/complications/*drug therapy/genetics/physiopathology ; Baclofen/pharmacology/therapeutic use ; Child ; *Clinical Trials as Topic ; Dendrites/drug effects/metabolism/pathology ; *Disease Models, Animal ; Fragile X Mental Retardation Protein/genetics/metabolism ; Fragile X Syndrome/complications/*drug therapy/genetics/pathology ; Humans ; Mice ; Protein Biosynthesis/drug effects ; Receptor, Metabotropic Glutamate 5 ; Receptors, Metabotropic Glutamate/metabolism ; *Translational Medical Research ; Young Adult
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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