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  • Animals  (667)
  • American Association for the Advancement of Science (AAAS)  (667)
  • Periodicals Archive Online (PAO)
  • 2010-2014  (667)
  • 1955-1959
  • 1940-1944
  • 2012  (667)
Collection
Keywords
Publisher
Years
  • 2010-2014  (667)
  • 1955-1959
  • 1940-1944
Year
  • 1
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    Conservation concerns in the deep (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hartmann, Aaron C -- Levin, Lisa A -- New York, N.Y. -- Science. 2012 May 11;336(6082):668-9. doi: 10.1126/science.336.6082.668-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22582242" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Aquatic Organisms ; *Ecosystem ; *Seawater
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Rocket launcher mechanism of collaborative actin assembly defined by single-molecule imaging (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-02
    Description: Interacting sets of actin assembly factors work together in cells, but the underlying mechanisms have remained obscure. We used triple-color single-molecule fluorescence microscopy to image the tumor suppressor adenomatous polyposis coli (APC) and the formin mDia1 during filament assembly. Complexes consisting of APC, mDia1, and actin monomers initiated actin filament formation, overcoming inhibition by capping protein and profilin. Upon filament polymerization, the complexes separated, with mDia1 moving processively on growing barbed ends while APC remained at the site of nucleation. Thus, the two assembly factors directly interact to initiate filament assembly and then separate but retain independent associations with either end of the growing filament.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613992/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613992/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breitsprecher, Dennis -- Jaiswal, Richa -- Bombardier, Jeffrey P -- Gould, Christopher J -- Gelles, Jeff -- Goode, Bruce L -- GM083137/GM/NIGMS NIH HHS/ -- GM43369/GM/NIGMS NIH HHS/ -- GM81648/GM/NIGMS NIH HHS/ -- R01 GM063691/GM/NIGMS NIH HHS/ -- R01 GM081648/GM/NIGMS NIH HHS/ -- R01 GM083137/GM/NIGMS NIH HHS/ -- R01 GM098143/GM/NIGMS NIH HHS/ -- R37 GM043369/GM/NIGMS NIH HHS/ -- T32 EB009419/EB/NIBIB NIH HHS/ -- T32 GM007596/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Jun 1;336(6085):1164-8. doi: 10.1126/science.1218062.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Brandeis University, Waltham, MA 02454, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22654058" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Cytoskeleton/*metabolism ; Actins/chemistry/*metabolism ; Adaptor Proteins, Signal Transducing/chemistry/*metabolism ; Adenomatous Polyposis Coli Protein/chemistry/*metabolism ; Animals ; Microscopy, Fluorescence ; Peptide Fragments/chemistry/metabolism ; Profilins/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Rabbits
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Climate change. Winds of change (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Qiu, Jane -- New York, N.Y. -- Science. 2012 Nov 16;338(6109):879-81. doi: 10.1126/science.338.6109.879.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23161970" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antarctic Regions ; *Climate Change ; Global Warming ; *Ice Cover ; Spheniscidae/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Regulatory science. Amid Europe's food fights, EFSA keeps its eyes on the evidence (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2012 Nov 30;338(6111):1146-7. doi: 10.1126/science.338.6111.1146.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23197512" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Consumer Advocacy/standards/*trends ; Consumer Organizations/standards/*trends ; *European Union ; Food Labeling/*standards ; *Food Safety ; *Food, Genetically Modified ; Guidelines as Topic/standards ; Italy ; Plants, Genetically Modified
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Molecular biology. A new start for protein synthesis (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dever, Thomas E -- New York, N.Y. -- Science. 2012 Jun 29;336(6089):1645-6. doi: 10.1126/science.1224439.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. tdever@nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22745408" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen Presentation/*genetics ; *Codon, Initiator ; Histocompatibility Antigens Class I/*genetics/*immunology ; Humans ; Protein Biosynthesis/*genetics ; *RNA, Transfer, Leu
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Natural enemies drive geographic variation in plant defenses (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-09
    Description: Plants defend themselves against attack by natural enemies, and these defenses vary widely across populations. However, whether communities of natural enemies are a sufficiently potent force to maintain polymorphisms in defensive traits is largely unknown. Here, we exploit the genetic resources of Arabidopsis thaliana, coupled with 39 years of field data on aphid abundance, to (i) demonstrate that geographic patterns in a polymorphic defense locus (GS-ELONG) are strongly correlated with changes in the relative abundance of two specialist aphids; and (ii) demonstrate differential selection by the two aphids on GS-ELONG, using a multigeneration selection experiment. We thereby show a causal link between variation in abundance of the two specialist aphids and the geographic pattern at GS-ELONG, which highlights the potency of natural enemies as selective forces.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zust, Tobias -- Heichinger, Christian -- Grossniklaus, Ueli -- Harrington, Richard -- Kliebenstein, Daniel J -- Turnbull, Lindsay A -- Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2012 Oct 5;338(6103):116-9. doi: 10.1126/science.1226397.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Evolutionary Biology and Environmental Studies and Zurich-Basel Plant Science Center, University of Zurich, Zurich CH-8057, Switzerland. tobias.zuest@cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23042895" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological/*genetics ; Animals ; Aphids/*physiology ; Arabidopsis/*genetics ; *Genetic Loci ; Geography ; Herbivory/*physiology ; Polymorphism, Genetic ; *Selection, Genetic ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-03
    Description: Multiple cancer-associated single-nucleotide polymorphisms (SNPs) have been mapped to conserved sequences within a 500-kilobase region upstream of the MYC oncogene on human chromosome 8q24. These SNPs may affect cancer development through altered regulation of MYC expression, but this hypothesis has been difficult to confirm. We generated mice deficient in Myc-335, a putative MYC regulatory element that contains rs6983267, a SNP accounting for more human cancer-related morbidity than any other genetic variant or mutation. In Myc-335 null mice, Myc transcripts were expressed in the intestinal crypts in a pattern similar to that in wild-type mice but at modestly reduced levels. The mutant mice displayed no overt phenotype but were markedly resistant to intestinal tumorigenesis induced by the APCmin mutation. These results establish that a cancer-associated SNP identified in human genome-wide association studies has a functional effect in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sur, Inderpreet Kaur -- Hallikas, Outi -- Vaharautio, Anna -- Yan, Jian -- Turunen, Mikko -- Enge, Martin -- Taipale, Minna -- Karhu, Auli -- Aaltonen, Lauri A -- Taipale, Jussi -- New York, N.Y. -- Science. 2012 Dec 7;338(6112):1360-3. doi: 10.1126/science.1228606. Epub 2012 Nov 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Science for Life Center, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23118011" target="_blank"〉PubMed〈/a〉
    Keywords: Adenomatous Polyposis Coli/genetics/pathology ; Animals ; Cell Transformation, Neoplastic/*genetics ; Colon/metabolism/pathology ; Enhancer Elements, Genetic/*genetics ; Humans ; Ileum/metabolism/pathology ; Intestinal Neoplasms/*genetics/pathology ; Mice ; Mice, Mutant Strains ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins c-myc/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Conservation. Citizen involvement in the U.S. Endangered Species Act (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brosi, Berry J -- Biber, Eric G N -- New York, N.Y. -- Science. 2012 Aug 17;337(6096):802-3. doi: 10.1126/science.1220660.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Studies, Emory University, Atlanta, GA 30322, USA. bbrosi@emory.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22903999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Databases, Factual ; Endangered Species/*legislation & jurisprudence/*statistics & numerical data ; Population ; Regression Analysis ; Turtles ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Behavior. Origins of cumulative culture (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurzban, Robert -- Barrett, H Clark -- New York, N.Y. -- Science. 2012 Mar 2;335(6072):1056-7. doi: 10.1126/science.1219232.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA. kurzban@psych.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22383839" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cultural Evolution ; Female ; Humans ; *Mental Processes ; *Problem Solving ; *Social Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Cell biology. A mitochondrial mystery, solved (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Divakaruni, Ajit S -- Murphy, Anne N -- New York, N.Y. -- Science. 2012 Jul 6;337(6090):41-3. doi: 10.1126/science.1225601.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Pharmacology Department, University of California-San Diego, La Jolla, CA 92093-0636, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22767917" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anion Transport Proteins/*metabolism ; Drosophila Proteins/*metabolism ; Drosophila melanogaster/*metabolism ; Humans ; Mitochondria/*metabolism ; Mitochondrial Membrane Transport Proteins/*metabolism ; Mitochondrial Membranes/*metabolism ; Mitochondrial Proteins/*metabolism ; Pyruvic Acid/*metabolism ; Saccharomyces cerevisiae/*metabolism ; Saccharomyces cerevisiae Proteins/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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