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  • Articles  (53,970)
  • Wiley  (19,825)
  • American Institute of Physics  (16,668)
  • Springer Nature  (11,203)
  • Nature Publishing Group  (4,716)
  • American Meteorological Society
  • Blackwell Publishing Ltd
  • 2005-2009  (53,970)
  • 2006  (53,970)
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  • 2005-2009  (53,970)
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  • 1
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    Production of giant marine diatoms and their export at oceanic frontal zones: Implications for Si and C flux from stratified oceans (2006)
    Wiley
    In:  EPIC3Global Biogeochemical Cycles, Wiley, 20(4), ISSN: 0886-6236
    Details
    Publication Date: 2016-01-18
    Description: From a synthesis of recent oceanic observations and paleo-data it is evident that certain species of giant diatoms including Rhizosolenia spp. Thalassiothrix spp. and Ethmodiscus rex may become concentrated at oceanic frontal zones and subsequently form episodes of mass flux to the sediment. Within the nutrient bearing waters advecting towards frontal boundaries, these species are generally not dominant, but they appear selectively segregated at fronts, and thus may dominate the export flux. Ancient Thalassiothrix diatom mat deposits in the eastern equatorial Pacific and beneath the Polar Front in the Southern Ocean record the highest open ocean sedimentation rates ever documented and represent vast sinks of silica and carbon. Several of the species involved are adapted to a stratified water column and may thrive in Deep Chlorophyll Maxima. Thus in oceanic regions and/or at times prone to enhanced surface water stratification (e.g., during meltwater pulses) they provide a mechanism for generating substantial biomass at depth and its subsequent export with concomitant implications for Si export and C drawdown. This ecology has important implications for ocean biogeochemical models suggesting that more than one diatom “functional type” should be used. In spite of the importance of these giant diatoms for biogeochemical cycling, their large size coupled with the constraints of conventional oceanographic survey schemes and techniques means that they are undersampled. An improved insight into these key species will be an important prerequisite for enhancing our understanding of marine biogeochemical cycling and for assessing the impacts of climate change on ocean export production.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
    Format: application/pdf
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  • 2
    Electronic Resource
    Electronic Resource
    News In Brief (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1048-1049 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] 200% ethanol boost from Oz sugar University of Queensland (UQ), Australia, molecular geneticist Robert Birch got more than he bargained for when he introduced a bacterial gene into sugarcane to convert sucrose into its high-value isomer, isomaltulose. In fact, the gene encoding sucrose isomerase, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0706-1048
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  • 3
    Electronic Resource
    Electronic Resource
    Profile of a bacterial tumor killer (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1484-1485 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Common bacteria, engineered to safely seek out and kill tumors, may well be the next generation of cancer therapeutics. In this issue, Bettegowda et al. report the genome sequence of one such bacterium, Clostridium novyi-NT, which has been engineered to be non-toxic by deleting the major systemic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1206-1484
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  • 4
    Electronic Resource
    Electronic Resource
    Anti-infective antibodies: finding the path forward (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1491-1493 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] This June, Basel-based Novartis Pharmaceuticals made a first reconnoiter into antimicrobial antibodies in its quest to find new weapons to fight infections. It paid $569 million to acquire NeuTec Pharmaceuticals of Manchester, UK, and its two late-stage products, both antibody fragments ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1206-1491
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  • 5
    Electronic Resource
    Electronic Resource
    Prospects for plant-derived antibacterials (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1504-1507 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The scarcity of disease in wild plants indicates that the success of plant defense mechanisms in combating pathogen infection rivals that of mammalian immune systems. Although there are some interesting parallels between plant and animal defense strategies—for instance, both groups sacrifice ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1206-1504
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  • 6
    Electronic Resource
    Electronic Resource
    Moving goalposts—regulatory oversight of antibacterial drugs (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1515-1519 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The US Food and Drug Administration (FDA) has recently rejected new antibiotics for common infections citing the requirement that the drugs intended to treat non-serious infections prove superior to placebo rather than active controls. With the introduction of more stringent statistical criteria, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1206-1515
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  • 7
    Electronic Resource
    Electronic Resource
    The business of developing antibacterials (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1521-1528 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] For developers of antibacterial products, this century began very much on the wrong foot. The number of pharmaceutical companies chasing antibiotics continued to drop, few genuinely new antibiotics reached the clinic and investors remained lukewarm toward startups in this sector. But, despite ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1206-1521
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  • 8
    Electronic Resource
    Electronic Resource
    What is a support vector machine? (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1565-1567 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A support vector machine (SVM) is a computer algorithm that learns by example to assign labels to objects. For instance, an SVM can learn to recognize fraudulent credit card activity by examining hundreds or thousands of fraudulent and nonfraudulent credit card activity reports. Alternatively, an ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1206-1565
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  • 9
    Electronic Resource
    Electronic Resource
    The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1573-1580 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Bacteriolytic anti-cancer therapies employ attenuated bacterial strains that selectively proliferate within tumors. Clostridium novyi-NT spores represent one of the most promising of these agents, as they generate potent anti-tumor effects in experimental animals. We have determined the 2.55-Mb ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1256
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  • 10
    Electronic Resource
    Electronic Resource
    Blue fluorescent proteins with enhanced brightness and photostability from a structurally targeted library (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1569-1571 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The utility of blue fluorescent protein (BFP) has been limited by its low quantum yield and rapid photobleaching. A library targeting residues neighboring the chromophore yielded a variant with enhanced quantum yield (0.55 versus 0.34), reduced pH sensitivity and a 40-fold increase in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1264
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