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  • Springer  (38,165)
  • Nature Publishing Group  (4,219)
  • 2020-2023
  • 2005-2009  (42,384)
  • 1950-1954
  • 1940-1944
  • 2005  (42,384)
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  • 2020-2023
  • 2005-2009  (42,384)
  • 1950-1954
  • 1940-1944
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  • 101
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    Electronic Resource
    Profile: Dmitry Morosov (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1465-1465 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotech venture creation in Russia can sometimes seem like roulette. Traditional models don't apply. Entrepreneurs must battle endemic bureaucracy, cronyism and corruption. And they must overcome a hostile business environment where government incentives are scarce, intellectual property (IP) ...
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    URL: http://dx.doi.org/10.1038/nbt1205-1465
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  • 102
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    Biotech drug market steadily expands (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1466-1466 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Unlike last year's billion dollar approvals, Avastin (bevacizumab) and Erbitux (cetuximab), no biotech blockbusters were launched in 2005 and none appear to be on the horizon. Almost half of the biologics license applications pending at the US Food and Drug Administration (FDA) are for ...
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    URL: http://dx.doi.org/10.1038/nbt1205-1466
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  • 103
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    News In Brief (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1463-1464 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Personalized reimbursement Revenue for pharmacogenomic testing is expected to grow ∼25% a year from 2004 to 2011, according to the report “US Genetic Diagnostics Market” released in October by consultancy Frost and Sullivan of San Antonio, Texas. Current reimbursement policies, ...
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    URL: http://dx.doi.org/10.1038/nbt1205-1463
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  • 104
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    Stem cell therapy or snake oil? (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1467-1469 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] This October, the US Food and Drug Administration (FDA) gave the green light to the Palo Alto, California-based company, Stem Cells, to inject fetal neural stem cells into the brains of children suffering from Battan disease, a devastating neurodegenerative disorder. Although this is an important ...
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    URL: http://dx.doi.org/10.1038/nbt1205-1467
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  • 105
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    Bacterial lessons in sausage making (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1494-1495 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Lactic acid bacteria have long been associated with the fermentation, acidification and preservation of food. People consume large amounts of these bacteria every day in products such as yogurt, cheese and fermented meats. In this issue, Chaillou et al. report the genome sequence of a highly ...
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    URL: http://dx.doi.org/10.1038/nbt1205-1494
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  • 106
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    Embryonic stem cells without embryos? (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1496-1497 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Against the backdrop of fierce debates over the ethics of research on human embryonic stem (ES) cells, the President's Council on Bioethics in 2004 proposed four ways of generating human ES cells without embryo destruction (http://www.bioethics.gov/reports/white_paper/). Although these proposals ...
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    URL: http://dx.doi.org/10.1038/nbt1205-1496
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  • 107
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    Research Highlights (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1498-1498 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A-maize-ing agronomic loci? The striking differences between ears of contemporary maize (right), its wild ancestor teosinte (left) and their hybrid (center) illustrate but one aspect of the extraordinary transformation of maize from its humble progenitor to the world's highest- yielding grain ...
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    URL: http://dx.doi.org/10.1038/nbt1205-1498
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  • 108
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    Managing your compensation expectations in today's environment: a third look (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1569-1570 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Three years ago, I noted that in terms of compensation, the biotech industry was a buyer's market. Eighteen months later, I suggested the industry was in a transition period heading towards a seller's market. Now, I can clearly conclude that we have moved into a seller's market: US biotech ...
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    URL: http://dx.doi.org/10.1038/nbt1205-1569
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  • 109
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    Expression systems (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1568-1568 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] MicroRNA assays TaqMan microRNA assays, from Applied Biosystems, are predesigned and validated probe and primer sets in a flexible format for the detection and quantification of mature human microRNA (miRNA) expression levels. The assays accommodate both large initial screening panels (many miRNAs ...
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    URL: http://dx.doi.org/10.1038/nbt1205-1568
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  • 110
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    How does gene expression clustering work? (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1499-1501 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Our ability to gather genome-wide expression data has far outstripped the ability of our puny human brains to process the raw data. We can distill the data down to a more comprehensible level by subdividing the genes into a smaller number of categories and then analyzing those. This is where ...
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    URL: http://dx.doi.org/10.1038/nbt1205-1499
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  • 111
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    China beckons to clinical trial sponsors (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 768-768 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The clinical trials market is opening up in China. The most recent evidence has been provided by the Danish Centre for Clinical and Basic Research (CCBR), which announced its intention to establish clinical research facilities in Beijing, independent of the state authorities. Low cost and ease of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0705-768
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  • 112
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    State of biotech sector—2004 (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 774-774 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In its latest annual review of the biotech industry, business consulting firm Ernst & Young finds a sector in flux (for 2003 stats see Nat. Biotechnol. 22, 789, 2004). Profitability still looks distant; although revenues for public companies were up by 17%, so were net losses. Employment was up ...
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    URL: http://dx.doi.org/10.1038/nbt0705-774
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  • 113
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    Regulatory regimes for transgenic crops (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 785-785 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: In presenting their justifications for reducing the regulatory burden on transgenic food crops (Nat. Biotechnol. 23, 439–444, 2005), we feel that Strauss and colleagues significantly misrepresent the implications and rationale of our report Genome Scrambling-Myth or Reality? ...
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    URL: http://dx.doi.org/10.1038/nbt0705-785a
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  • 114
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    Guidelines for human embryonic stem cell research (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 793-794 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The limited federal role in funding and monitoring research involving human embryonic stem (hES) cells has raised concerns among the scientific community that the field is progressing without adequate guidance. In response, the US National Academies set up a committee, which we cochaired, to ...
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    URL: http://dx.doi.org/10.1038/nbt0705-793
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  • 115
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    'On-the-fly' or 'generate-first' modeling? (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1344-1345 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: In a paper in the January issue (Nat. Biotechnol. 23, 131–136, 2005), Lok and Brent report methods and software, called Moleculizer, for automatically generating computational models of biochemical systems. Such rule-based modeling tools are needed to study systems marked by ...
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    URL: http://dx.doi.org/10.1038/nbt1105-1344
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  • 116
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    The patentability of antibodies in the United States (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1079-1080 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Two recent court cases, Noelle v. Lederman and SmithKline Beecham v. Apotex, shed light on the patentability of antibodies. The subtleties surrounding application of US patent statutes 35 USC §§ 102 (novelty and loss of right to patent), 103 (nonobvious subject matter) and 112 ...
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    URL: http://dx.doi.org/10.1038/nbt0905-1079
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  • 117
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    Molecule–kinase interaction map (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1346-1346 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: We read with interest the article by Fabian et al. in the March 2005 issue (Nat. Biotechnol. 23, 329−336, 2005) entitled “A small molecule–kinase interaction map for clinical kinase inhibitors.” Although the study is an elegant attempt at rapidly determining ...
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    URL: http://dx.doi.org/10.1038/nbt1105-1346a
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  • 118
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    Research Highlights (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1093-1093 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Cancer double punch As pharmacological strategies become more complex, technologies that can deliver multiple compounds with fine temporal and spatial control are expected to improve clinical outcomes. A case in point is cancer treatments that combine antiangiogenesis drugs and conventional ...
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    URL: http://dx.doi.org/10.1038/nbt0905-1093
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  • 119
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    Software (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1181-1181 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Chromatography data system Thermo Electron has released version 8.0 of the Atlas chromatography data system, providing enhancements in data acquisition and integration with laboratory information management systems (LIMS) for greater lab productivity. Atlas 8.0 improves instrument control ...
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    URL: http://dx.doi.org/10.1038/nbt0905-1181b
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  • 120
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    Selecting and screening recombinant antibody libraries (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1105-1116 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] During the past decade several display methods and other library screening techniques have been developed for isolating monoclonal antibodies (mAbs) from large collections of recombinant antibody fragments. These technologies are now widely exploited to build human antibodies with high affinity and ...
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    URL: http://dx.doi.org/10.1038/nbt1126
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  • 121
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    Human antibodies from transgenic animals (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1117-1125 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Laboratory mice provide a ready source of diverse, high-affinity and high-specificity monoclonal antibodies (mAbs). However, development of rodent antibodies as therapeutic agents has been impaired by the inherent immunogenicity of these molecules. One technology that has been explored to generate ...
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    URL: http://dx.doi.org/10.1038/nbt1135
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  • 122
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    Overexpression of an Arabidopsis thaliana ABC transporter confers kanamycin resistance to transgenic plants (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1177-1180 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Selectable markers of bacterial origin such as the neomycin phosphotransferase type II gene, which can confer kanamycin resistance to transgenic plants, represent an invaluable tool for plant engineering. However, since all currently used antibiotic-resistance genes are of bacterial origin, there ...
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    URL: http://dx.doi.org/10.1038/nbt1134
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  • 123
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    Arming antibodies: prospects and challenges for immunoconjugates (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1137-1146 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Immunoconjugates—monoclonal antibodies (mAbs) coupled to highly toxic agents, including radioisotopes and toxic drugs (ineffective when administered systemically alone)—are becoming a significant component of anticancer treatments. By combining the exquisite targeting specificity of ...
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    URL: http://dx.doi.org/10.1038/nbt1141
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  • 124
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    Erratum: Leaders and laggards in the stem cell enterprise (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1018-1018 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nat. Biotechnol. 23, 775–777 (2005) On page 776, column 3, paragraph 3, line 8, one of the recipients of the Starr Foundation gift for stem cell research was reported to be Rochester University; it should have read Rockefeller ...
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    URL: http://dx.doi.org/10.1038/nbt0805-1018b
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  • 125
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    Assays (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1019-1019 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Cell function assays Designed for Guava Technologies' EasyCyte benchtop microcytometry system, four new assays expand Guava's current suite of assays for assessing cellular function in cancer-related and other areas of research, including mitochondrial membrane potential, cellular proliferation ...
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    URL: http://dx.doi.org/10.1038/nbt0805-1019b
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  • 126
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    People (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1024-1024 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Millennium Pharmaceuticals (Cambridge, MA, USA) has announced its new president and CEO: Deborah Dunsire (left), most recently head of Novartis Pharmaceuticals' North American oncology operations. Dr. Dunsire also joins Millennium's board of directors. She succeeds Mark Levin, cofounder and CEO ...
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  • 127
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    Next-generation monoclonals less profitable than trailblazers? (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 906-906 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A new study has suggested that therapeutics based on monoclonal antibodies (mAbs) are far more likely to be commercially successful than their small-molecule predecessors. For the next generation of mAb-involved biotech companies, it may not be as easy as before to sustain that trend. Although mAbs ...
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  • 128
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    News In Brief (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 911-912 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] DNA patenting down The number of DNA-related patents issued by the US Patent and Trademark Office declined in 2004. So says the Washington, DC-based intellectual property law firm Finnegan Henderson, which conducted a DNA patent study published June 20. According to the 2005 Biotechnology ...
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  • 129
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    Beer giant blindsides Ventria's pharmacrop (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 636-636 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Ventria Bioscience, a Sacramento, California-based biotech company scuttled plans in May for growing two of its genetically modified (GM) rice varieties in southern Missouri this year after being blindsided by beer maker Anheuser-Busch. Ventria officials describe the decision as a minor setback ...
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    URL: http://dx.doi.org/10.1038/nbt0605-636
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  • 130
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    Will Bt cotton remain effective in India? (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 927-928 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: A news article by K.S. Jayaraman et al. in the February issue (Nat. Biotechnol. 23, 158, 2005) highlights a model for predicting the emergence of resistance in the cotton bollworm Helicoverpa armigera to cotton varieties containing the cry1Ac gene that encodes Bacillus thuringiensis ...
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    Recent patent applications in systems biology (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 939-939 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Recent patent applications in systems biology Table ...
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    URL: http://dx.doi.org/10.1038/nbt0805-939
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    Discovering DNA regulatory elements with bacteria (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 942-944 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Following nearly a decade's worth of genome-scale gene expression profiling and the more recent sequencing of multiple higher eukaryotic genomes, attention is now shifting towards determining the regulatory mechanisms underlying gene expression patterns. A major obstacle in understanding ...
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    URL: http://dx.doi.org/10.1038/nbt0805-942
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    Research Highlights (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 949-949 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fishing for genes in hematopoiesis Microarray experiments often reveal large numbers of differentially expressed genes, but unpacking the biological meaning of such gene lists takes additional, painstaking work. Eckfeldt et al. now show how a functional screen in zebrafish embryos can be used to ...
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    Stepwise engineering to produce high yields of very long-chain polyunsaturated fatty acids in plants (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1013-1017 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Very long chain polyunsaturated fatty acids (VLCPUFAs) such as arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are valuable commodities that provide important human health benefits. We report the transgenic production of significant amounts of AA and EPA ...
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    URL: http://dx.doi.org/10.1038/nbt1107
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    'Omic diagnostics trip up on way to clinic (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 769-769 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As two diagnostics companies learned recently at their expense, the FDA is taking a hard look at gene and protein expression–based tests. Perhaps harder than some developers had hoped, after another kind of 'omic test, based on genetic variation, first received approval in late 2004. For now, ...
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    Profile: Heinrich Henckel (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 773-773 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A lawyer by training, Heinrich Henckel has been schooled in the art of building a strong argument to support his case. Now in his position as CEO of the SWX Swiss Exchange, he asserts that the exchange has everything that a biotech company could wish for when looking to list in Europe. Even so, he ...
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    Regulatory regimes for transgenic crops (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 785-787 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: In the April issue (Nat. Biotechnol. 23, 439–444, 2005), Strauss and colleagues argue that the methods used to produce food crops should not be the focus of regulatory oversight, only the phenotypic traits of the resultant plants as defined in terms of standard agricultural ...
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    Reply to "Dual-color, whole-body imaging in mice" (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 791-791 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Ntziachristos et al. respond: The physics of photon propagation in tissues unequivocally supports the notion that planar imaging is surface weighted because signal intensity from deep-seated tumors drops exponentially as a function of depth. Therefore, planar imaging will preferentially detect and ...
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    The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 795-797 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Since the first report of the derivation of human embryonic stem (hES) cells in 1998, the number of research groups working on this unique and versatile type of cultured cell has expanded rapidly. The original observation that pluripotent stem cells could be derived at reasonable frequency from the ...
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    When a long shot is worth a shot (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 805-805 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotech speculators crave newer, productless and profitless companies with exciting late-stage, high-potential product candidates. But with information today so easy to come by, no candidate remains hidden for long. That's why it's both a mystery and a delight to find an unknown biotech ...
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    The gatekeepers of hES cell products (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 817-819 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Access to human embryonic stem (hES) cells in the United States is controlled by a triumvirate comprising the Wisconsin Alumni Research Foundation (WARF; Madison, WI, USA), Geron (Menlo Park, CA, USA) and the US National Institutes of Health (NIH; Bethesda, MD, USA). The exclusive ownership of hES ...
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    Beware the biotech barker (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 538-538 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotech company executives' public statements can tell you a lot, but even the most experienced investors have trouble separating their spin from fact. This is especially difficult because most biotechs are development-stage companies lacking profits, dependent for years on selling hope and dreams. ...
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    Patents (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 550-550 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Recent patent applications in microarrays Table ...
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    Reverse engineering gene regulatory networks (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 554-555 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biological systems are wondrously and notoriously complex. Over the last fifty years, molecular biology has helped to reveal the vast and stunning array of components in biological systems. Now, we face the even more daunting challenge of systems biology: determining how all these puzzle pieces ...
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    Erratum: Julian Thurston (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 896-896 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nat. Biotechnol. 23, 517 (2005) The interview suggested that Julian Thurston was a nonexecutive director of The Cancer Research Campaign. Although Julian Thurston served as a nonexecutive director of Cancer Research Campaign Technology Limited for several years and then of Cancer Research Ventures ...
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    Corrigendum: Genetically enhanced cows resist intramammary Staphylococcus aureus infection (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 897-897 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nat. Biotechnol. 23, 445–451 (2005) In the abstract on page 445, the quantities given for lysostaphin in the following sentences are incorrect: “To test the feasibility of protecting animals through genetic engineering, transgenic cows secreting lysostaphin at concentrations ranging ...
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    Software (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 898-898 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Scientific imaging Improvision's Volocity 3.5 is designed for 3D and 4D imaging. The software takes advantage of the high-performance 64-bit Windows operating system for features such as the colocalization tab, which shows a preview of the selected pair of channels for the current timepoint and ...
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    The first 100 days: a biotech CEO survey (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 899-900 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The arrival of a new chief executive officer to head up a company, large or small, is always a major event—especially for the CEO. The first 100 days constitute a critical phase, a period famously charged with both potential and pitfalls. The new CEO, absorbing facts and personal reflections ...
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    Engineering vascularized skeletal muscle tissue (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 879-884 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] One of the major obstacles in engineering thick, complex tissues such as muscle is the need to vascularize the tissue in vitro. Vascularization in vitro could maintain cell viability during tissue growth, induce structural organization and promote vascularization upon implantation. Here we describe ...
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    New sources of pancreatic β-cells (2005)
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    Nature biotechnology 23 (2005), S. 857-861 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Two major initiatives are under way to correct the β-cell deficit of diabetes: one would generate β-cells ex vivo that are suitable for transplantation, and the second would stimulate regeneration of β-cells in the pancreas. Studies of ex vivo expansion suggest that β-cells have ...
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    Stem and progenitor cell–based therapy of the human central nervous system (2005)
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    Nature biotechnology 23 (2005), S. 862-871 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Multipotent neural stem cells, capable of giving rise to both neurons and glia, line the cerebral ventricles of all adult animals, including humans. In addition, distinct populations of nominally glial progenitor cells, which also have the capacity to generate several cell types, are dispersed ...
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    The YIC factor (2005)
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    Nature biotechnology 23 (2005), S. 1187-1187 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] When the French Parliament votes on its budget this month, a new set of proposals to foster the growth of nascent life science ventures looks set to remain low on the list of priorities of national politicians. That is a shame because the proposals offer biotech firms an opportunity to throw off ...
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    Korean biotechs seize opportunity to list on public markets (2005)
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    Nature biotechnology 23 (2005), S. 1189-1190 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Cash-starved biotech companies in Korea are hoping that changes in the listing rules for the Korean Stock Exchange introduced earlier this year will allow them to float. But industry observers caution that access to the public market will only partly alleviate the problems faced by Korean biotech ...
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    Chiron's manufacturing misfortunes boost competitors (2005)
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    Nature biotechnology 23 (2005), S. 1191-1191 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Chiron's ongoing problems in influenza vaccine production have raised serious questions about the Emeryville, California company's future ability to compete in this particular segment of the vaccine market. And with Basel-based Novartis's recent bid for the Chiron shares it doesn't already own, the ...
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    New IGF drug stirs competition in growth factor segment (2005)
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    Nature biotechnology 23 (2005), S. 1192-1192 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] An important molecule for growth recently received approval in the US. This approval heralds the first medical application of insulin-like growth factor 1 (IGF-1) as a drug to promote growth in a rare group of very small children. But to be commercially successful, makers of IGF-1 will have to ...
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    Keeping your head when all about you are losing theirs (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 662-662 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Every investor at some point faces a stock crash. No matter how much you research the business and scrutinize the risks, you will rise one day to find that a stock has plunged 25%, 50% or even more. Panic and inertia ensue. What to do? There is no one-size-fits-all answer, because unless a ...
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    News In Brief (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1195-1196 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] US trails Europe in IPOs Biopharma firms in Europe are on target to raise more money through initial public offerings (IPOs) than their counterparts in the US this year. In the first eight months of 2005, European biopharmas raised $533 million to the $513 million raised by US ...
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    Eco-friendly insect management (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 432-433 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In area-wide control programs, a genetic method called the Sterile Insect Technique (SIT) can be used to successfully suppress economically important pest species. SIT involves mass production of the target pest, sterilization by irradiation and sustained release over entire regions of large ...
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    Erratum: Agbio groups join BIO (2005)
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    Nature biotechnology 23 (2005), S. 488-488 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nat. Biotechnol. 22, 1493 (2004) Erratum: Nat. Biotechnol. 23, 117 (2005) The erratum incorrectly stated that “CropLife International...sometimes receives funding from CBI.” In fact, CropLife International provides funding to the Council for Biotechnology Information (CBI), not the ...
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    Corrigendum: Problems in monitoring horizontal gene transfer in field trials of transgenic plants (2005)
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    Nature biotechnology 23 (2005), S. 488-488 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nat. Biotechnol. 22, 1105–1109 (2004) On page 1108, paragraph 1, line 7, reference 49 in the statement “B. thuringiensis has 'a significant history of mammalian pathogenicity'46 and is thus not irrelevant to food safety or other environmental issues” was inappropriately cited ...
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    Bioinformatics (2005)
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    Nature biotechnology 23 (2005), S. 493-493 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Open environment With the Bioinformatics Toolbox 2.0, researchers can perform mass-spectrometry data analysis, perform statistical inference and prediction, view graphs and conduct enhanced genomic and proteomic sequence analysis. Most functions are implemented in the open MATLAB language, ...
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    People (2005)
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    Nature biotechnology 23 (2005), S. 506-506 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Cell Genesys (S. San Francisco, CA, USA) has announced the appointment of Robert J. Dow to the newly created position of senior vice president, medical affairs. Dr. Dow was most recently CEO of UK-based Biolitec Pharma, and previously held senior positions at Quantanova and Scotia Holdings. His ...
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    Extracellular secretion of polypeptides using a modified Escherichia coli flagellar secretion apparatus (2005)
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    Nature biotechnology 23 (2005), S. 475-481 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We developed a modified flagellar type III secretion apparatus to secrete heterologous polypeptides into the growth medium of Escherichia coli. The secretion was facilitated by fusing the 173-bp untranslated DNA fragment upstream of the gene fliC (encoding flagellin) as well as a transcriptional ...
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    Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 457-462 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Short interfering RNAs (siRNAs) that mediate specific gene silencing through RNA interference (RNAi) are widely used to study gene function and are also being developed for therapeutic applications. Many nucleic acids, including double- (dsRNA) and single-stranded RNA (ssRNA), can stimulate innate ...
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    A dose of reality for rational therapies (2005)
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    Nature biotechnology 23 (2005), S. 267-267 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Many of biotech's greatest therapeutic successes are drugs used as adjuncts to conventional cancer therapies. Erythropoietin-α and granulocyte-macrophage colony stimulating factor are blockbusters that ameliorate the harmful effects of cytotoxic chemotherapy regimes. Interferon-α was ...
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    Mind the (biomedical funding) gap (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1217-1218 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Think of novel biomedical technologies as beautiful (not to mention valuable) seashells sitting on a pristine, sandy beach. The most fully developed of these shells/technologies are closest to the water's edge, whereas the youngest sit at or above the high tide line.... In this scenario, venture ...
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    A taxing dilemma (2005)
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    Nature biotechnology 23 (2005), S. 1219-1219 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] It is a truth universally acknowledged that no one should pay one single shekel more of tax than required to stay out of jail. Therefore, it follows that investors should consider taxes when selling shares and taking profits, right? Wrong. Beginning investors incorrectly hold stocks too long to pay ...
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    Rejecting the gambler's principle (2005)
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    Nature biotechnology 23 (2005), S. 1220-1220 
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    Notes: [Auszug] Through one of those tricks that history likes to play on us, the 1960s and 1970s saw both the emergence of a visionary genetics enterprise and the last gasps of a postwar critique of technology. That critique had been heavily fed by a widespread anxiety about nuclear weapons proliferation and it ...
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    In biomarkers we trust? (2005)
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    Nature biotechnology 23 (2005), S. 297-304 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] What drug and diagnostic companies want, more than anything, is the ability to predict the future. Rather than waiting years and studying thousands of patients, they want to be able to tell who has a disease, which patients will benefit from what drug and whether a drug will have unintended ...
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    Breaking the barriers to global gene delivery (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 305-306 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] For both scientist and physician, the biggest challenge to the use of viral vectors for gene delivery is how to introduce and express the therapeutic gene in a sufficient number of cells to achieve clinical efficacy. This is particularly true for the treatment of heart disease and muscular ...
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    Bringing amyloid into focus (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 552-554 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Until recently using clinical imaging technologies such as positron emission tomography (PET) and magnetic resonance imaging (MRI), the amyloid plaques that accumulate in the brains of patients with Alzheimer disease have been difficult, if not impossible, to detect in vivo. In this issue ...
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    Research Highlights (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 559-559 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Cell therapy for Alzheimer A phase I clinical trial in eight individuals with mild Alzheimer disease appears to have slowed the decline of cognitive function. The treatment involved transplantation into the brain of autologous fibroblasts genetically modified to express nerve growth factor (NGF). ...
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    People (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 632-632 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Stressgen Biotechnologies (Victoria, BC, Canada) has appointed Gregory M. McKee as the company's president and CEO, succeeding Dan Korpolinski who is leaving to pursue other interests. Mr. McKee, who has served as Stressgen's chief financial officer and vice president of corporate development for ...
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    Quantitative mouse brain proteomics using culture-derived isotope tags as internal standards (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 617-621 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] An important challenge for proteomics is to be able to compare absolute protein levels across biological samples. Here we introduce an approach based on the use of culture-derived isotope tags (CDITs) for quantitative tissue proteome analysis. We cultured Neuro2A cells in a stable isotope-enriched ...
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    It takes a village to grow a tissue (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1237-1239 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Tissue engineering aims to grow tissue replacements by combining cells and matrices under defined laboratory conditions. The shortage of donor tissues and organs and the increasing demand for tissue repair from an aging population have catalyzed research in the field. A US National Institutes of ...
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    Bacteria to the rescue (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1236-1237 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As a consequence of industrialization, humans have developed and released into the environment numerous chemical compounds that would not otherwise be present. Many of these chemicals and their by-products have accumulated in our soil, water and elsewhere, resulting in severe detrimental effects on ...
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    Research Highlights (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1241-1241 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Plant probiotic Considerable interest centers on nontransgenic approaches to improve crop productivity. One such approach may be to simply douse seeds with a beneficial endophytic fungus, Piriformospora indica. A new report suggests that application of the fungus to barley not only increases ...
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    Corrigendum: Design of a genome-wide siRNA library using an artificial neural network (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1315-1315 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nat. Biotechnol. 23, 995–1001 (2005) On page 1,000, in the last Methods section, line 4 from bottom of page, “HeLa cells were treated with 100 mM Deferoxamine Mesylate” should have read “HeLa cells were treated with 100 μM Deferoxamine Mesylate.” In the ...
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    Regulatory frameworks in developing countries (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 413-413 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Although we appreciate that the recent Nature Biotechnology supplement 'Health Biotechnology Innovation in Developing Countries' was concerned largely with the economics of biotech manufacturing in developing countries, we feel there were some serious gaps in the coverage ...
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    Great company, bad stock (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 173-173 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Want to know why biotech investors can name Genentech (S. San Francisco, CA, USA; NYSE:DNA) in their sleep as the industry's most valuable player? Easy. According to Samuel Isaly, manager of the Eaton Vance Worldwide Health Sciences Fund, only 40 of 1,000 biotech companies in biotech's history have ...
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    Golden Rice gets a boost from maize (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 429-430 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Golden Rice—genetically engineered to produce β-carotene in its seeds—was widely heralded in the popular media as a potential means of combating vitamin A deficiency. Yet the low levels of β-carotene (a pro-vitamin A carotenoid) in the kernels of this transgenic crop have ...
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    A new school for screening (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 184-186 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As the pharmaceutical industry continues to struggle to improve productivity, many are questioning all aspects of the drug discovery process. One issue, perhaps the heart of the problem, is that of efficiently discovering high-quality drug leads. In this issue, Card et al. introduce a ...
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    An individual approach (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1317-1318 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] It would be the ultimate in personal service: medical treatment tailored to match exactly your personal genetic makeup. Understanding how your body is likely to react to certain therapies would potentially eliminate side effects and increase the efficacy of the drugs you take. That, loosely, is the ...
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    People (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1320-1320 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] David Bentley has been appointed chief scientist at Solexa (Hayward, CA, USA and Cambridge, UK). He joins the company from the Wellcome Trust Sanger Institute, where he held the position of head of human genetics. As a founding member of the institute's management team, Dr. Bentley was a key ...
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    Cell & tissue culture (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1316-1316 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Microcarrier beads HyClone Laboratories' HyQSpheres are small beads used in cell culture applications. They can be maintained in suspension and their surface chemistry facilitates attachment and growth of anchorage-dependent cells, allowing large-scale culture inside a relatively small footprint. ...
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    Skeptics demand duplication of controversial fertility claim (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 911-911 
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    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Finding that stem cells in the bone marrow can regenerate egg cells reverses dogma. When Jonathan Tilly claimed in March 2004 that stem cells could replenish the supply of eggs in a mammalian ovary, experts in the field balked. But his claim in July that those stem cells may reside not in the ...
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    Complaints of gender bias compel NIH to revise awards scheme (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 912-912 
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    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Selection of judges and applicants for the NIH Director's Pioneer Awards has been revamped When the US National Institutes if Health (NIH) announced the winners of the first annual NIH Director's Pioneer Award last year, one fact stood out: all nine awardees were men. This year, thanks to a flurry ...
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    Loss of grants review board leaves Australian scientists wary (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 910-910 
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    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Restructuring of medical research agency is up in the air. Grants given by Australia's primary funding agency for basic research will go through one less step on their way to approval, a move scientists say will leave the process vulnerable to political whim. The nation's medical and health ...
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    Profile: Ben Barres (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 916-916 
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    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Neurobiologist Ben Barres may have a successful career, but he knows exactly what discrimination looks like. And over the years, he has learned to fight back. Ask Ben Barres whether women in science are treated fairly. But first make sure you have plenty of time to hear his answer.... Barres is a ...
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    Senescence comes of age (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 920-922 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] More than 40 years ago, Hayflick observed that cells can lose the ability to divide after a limited number of cell divisions, and enter a state of proliferative arrest. This state of cellular senescence, we now know, is similar to apoptosis—involving a gene-directed program that irrevocably ...
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    Modulating autoimmunity: pick your PI3 kinase (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 924-925 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Drugs that target enzymes with multiple isoforms run the risk of affecting too many cellular processes, because many isoforms perform redundant functions. Gene knockout mice of these molecules, however, often reveal selective roles, raising the possibility of precise modulation through use of ...
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    Rescuing troubled vessels in Alzheimer disease (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 923-924 
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    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Most efforts to unravel the mechanisms of Alzheimer disease, the main cause of dementia in the elderly, have focused on the damaging effects of the amyloid-β peptide (Aβ), which accumulates in the brains of individuals with the disease. A growing body of evidence, however, suggests that ...
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    Masters of angiogenesis (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 925-927 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The concept of treating tumors by cutting off angiogenesis, the process of new blood vessel growth, is powerful. But in practice, results of clinical trials of angiogenesis inhibitors—such as bevacizumab, the monoclonal antibody to vascular endothelial growth factor (VEGF) have not been ...
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    RIGing a virus trap (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 929-930 
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    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] A new player in the innate defense system has recently emerged, RIG-I (retinoic acid-inducible gene I). RIG-I recognizes the RNA of RNA viruses and has a more famous counterpart in innate immune defense, the Toll-like receptors (TLRs), which also recognize conserved molecular components of ...
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    A plague upon the phagocytes (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 927-928 
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    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Plague is arguably the leading cause of pathogen-related death in human history. Epidemics of bubonic plague—the Black Death—killed an estimated 200 million Europeans during the Middle Ages. Even today, there are isolated outbreaks, and a recent epidemic in Madagascar suggests that ...
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    Research Highlights (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 931-931 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] What doesn't kill you... Low doses of antibiotics can have an unintended effect—instead of killing bacteria, some antibiotics promote the formation of biofilms, slimy aggregates of bacteria that resist drug treatment (Nature 435, 1171–1175). Lucas Hoffman et al. examine in vitro ...
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    Hatching a drug (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 930-930 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Human monoclonal antibodies have hatched from chicken eggs (Nat. Biotechnol. 23, 1159–1169). Generating antibodies in eggs could prove more efficient than more traditional methods of cell culture.... To generate antibody-producing eggs, Lei Zhu et al. created an antibody transgene hooked up ...
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    Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 1005-1011 
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    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Approximately 50% of the US population received smallpox vaccinations before routine immunization ceased in 1972 for civilians and in 1990 for military personnel. Several studies have shown long-term immunity after smallpox vaccination, but skepticism remains as to whether this will translate into ...
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    An astrocytic basis of epilepsy (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 973-981 
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    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Hypersynchronous neuronal firing is a hallmark of epilepsy, but the mechanisms underlying simultaneous activation of multiple neurons remains unknown. Epileptic discharges are in part initiated by a local depolarization shift that drives groups of neurons into synchronous bursting. In an attempt to ...
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    Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 966-972 
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    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Demyelination is the hallmark of numerous neurodegenerative conditions, including multiple sclerosis. Oligodendrocyte progenitors (OPCs), which normally mature into myelin-forming oligodendrocytes, are typically present around demyelinated lesions but do not remyelinate affected axons. Here, we ...
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