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1

Digitale Medien

Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay (2005)

Cleary, Michael D ; Meiering, Christopher D ; Jan, Eric ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 232-237

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Standard microarrays measure mRNA abundance, not mRNA synthesis, and therefore cannot identify the mechanisms that regulate gene expression. We have developed a method to overcome this limitation by using the salvage enzyme uracil phosphoribosyltransferase (UPRT) from the protozoan Toxoplasma ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1061

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2

Digitale Medien

Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans (2005)

Prust, Christina ; Hoffmeister, Marc ; Liesegang, Heiko ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 195-200

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Gluconobacter oxydans is unsurpassed by other organisms in its ability to incompletely oxidize a great variety of carbohydrates, alcohols and related compounds. Furthermore, the organism is used for several biotechnological processes, such as vitamin C production. To further our understanding of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1062

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3

Digitale Medien

Detection of parallel functional modules by comparative analysis of genome sequences (2005)

Li, Huiying ; Pellegrini, Matteo ; Eisenberg, David

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 253-260

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Parallel functional modules are separate sets of proteins in an organism that catalyze the same or similar biochemical reactions but act on different substrates or use different cofactors. They originate by gene duplication during evolution. Parallel functional modules provide versatility and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1065

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4

Digitale Medien

Minimum information requested in the annotation of biochemical models (MIRIAM) (2005)

Finney, Andrew ; Hucka, Michael ; Bhalla, Upinder S ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1509-1515

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Most of the published quantitative models in biology are lost for the community because they are either not made available or they are insufficiently characterized to allow them to be reused. The lack of a standard description format, lack of stringent reviewing and authors' carelessness are the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1156

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5

Digitale Medien

The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K (2005)

Chaillou, Stéphane ; Champomier-Vergès, Marie-Christine ; Cornet, Monique ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1527-1533

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Lactobacillus sakei is a psychrotrophic lactic acid bacterium found naturally on fresh meat and fish. This microorganism is widely used in the manufacture of fermented meats and has biotechnological potential in biopreservation and food safety. We have explored the 1,884,661-base-pair (bp) circular ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1160

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6

Digitale Medien

Efficient differentiation of human embryonic stem cells to definitive endoderm (2005)

D'Amour, Kevin A ; Agulnick, Alan D ; Eliazer, Susan ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1534-1541

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use of hES cells in therapeutic applications. Of great interest are organs derived from definitive endoderm, such as the pancreas. We have ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1163

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7

Digitale Medien

Combined static and dynamic analysis for determining the quality of time-series expression profiles (2005)

Simon, Itamar ; Siegfried, Zahava ; Ernst, Jason ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1503-1508

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Expression profiling of time-series experiments is widely used to study biological systems. However, determining the quality of the resulting profiles remains a fundamental problem. Because of inadequate sampling rates, the effect of arrest-and-release methods and loss of synchronization, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1164

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8

Digitale Medien

The problem with potency (2005)

Scott, Christopher Thomas

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1037-1039

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] As the $30 billion monoclonal antibody (mAb) market moves from murine-based to chimeric and fully human products, it grows at a compounded clip of nearly 20% per year (see ). This spectacular growth—Synagis (pavilivizumb; MedImmune, Gaithersburg, Maryland), Herceptin (trastuzumab; ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1037

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9

Digitale Medien

Problems with metagenomic screening (2005)

de Lorenzo, Victor

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1045-1045

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: The paper by Kazuya Watanabe and colleagues published in the January issue (Nat. Biotechnol. 23, 88–93, 2005) is framed both in the paper itself and in the accompanying News & Views by Jo Handelsman (Nat. Biotechnol. 23, 38–39, 2005) as an astute, general genetic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1045a

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10

Digitale Medien

Reply to "Problems with metagenomic screening" (2005)

Watanabe, Kazuya ; Uchiyama, Taku

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1045-1046

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Watanabe and colleagues respond: de Lorenzo outlines some possible limitations of the substrate-induced gene expression screening (SIGEX) method. Although we discussed many of the points in his letter in our paper, it is worth reiterating them to emphasize the challenges faced in designing a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1045b

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