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  • Articles  (495)
  • United States  (275)
  • Female  (170)
  • Temperature  (62)
  • 2000-2004  (495)
  • 2003  (495)
  • Chemistry and Pharmacology  (495)
  • Education
  • Electrical Engineering, Measurement and Control Technology
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  • Articles  (495)
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  • 2000-2004  (495)
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  • 1
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    Biomolecular interactions at phospholipid-decorated surfaces of liquid crystals (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: The spontaneous assembly of phospholipids at planar interfaces between thermotropic liquid crystals and aqueous phases gives rise to patterned orientations of the liquid crystals that reflect the spatial and temporal organization of the phospholipids. Strong and weak specific-binding events involving proteins at these interfaces drive the reorganization of the phospholipids and trigger orientational transitions in the liquid crystals. Because these interfaces are fluid, processes involving the lateral organization of proteins (such as the formation of protein- and phospholipid-rich domains) are also readily imaged by the orientational response of the liquid crystal, as are stereospecific enzymatic events. These results provide principles for label-free monitoring of aqueous streams for molecular and biomolecular species without the need for complex instrumentation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brake, Jeffrey M -- Daschner, Maren K -- Luk, Yan-Yeung -- Abbott, Nicholas L -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2094-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical and Biological Engineering, University of Wisconsin, Madison, 1415 Engineering Drive, Madison, WI 53706-1607, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684814" target="_blank"〉PubMed〈/a〉
    Keywords: 1,2-Dipalmitoylphosphatidylcholine/chemistry ; Biphenyl Compounds/*chemistry ; Calcium ; Catalysis ; Crystallization ; Fluorescence ; Glass ; Gold ; Hydrolysis ; Micelles ; Nitriles/*chemistry ; Phosphatidylcholines/chemistry ; Phospholipases A/*metabolism ; Phospholipids/*chemistry ; Quaternary Ammonium Compounds/chemistry ; Silanes/chemistry ; Temperature ; Water/chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Scientific community. The trials of Thomas Butler (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- Malakoff, David -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2054-63.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684799" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioterrorism ; Clinical Trials as Topic/*economics/standards ; Contracts ; *Fraud ; History, 21st Century ; Humans ; *Jurisprudence ; Law Enforcement ; Plague/drug therapy ; Security Measures ; Sepsis/drug therapy ; Specimen Handling/standards ; Tanzania ; Texas ; United States ; United States Government Agencies ; Universities ; *Yersinia pestis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Science and government. Disclosure in regulatory science (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michaels, David -- Wagner, Wendy -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2073.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental and Occupational Health, George Washington University School of Public Health and Health Services, Washington, DC, 20052, USA. eohdmm@gwumc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684806" target="_blank"〉PubMed〈/a〉
    Keywords: Confidentiality ; *Conflict of Interest ; *Disclosure ; *Government Regulation ; *Private Sector ; Public Policy ; Research/*standards ; Research Support as Topic ; United States ; *United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Generation of viable cholesterol-free mice (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wechsler, A -- Brafman, A -- Shafir, M -- Heverin, M -- Gottlieb, H -- Damari, G -- Gozlan-Kelner, S -- Spivak, I -- Moshkin, O -- Fridman, E -- Becker, Y -- Skaliter, R -- Einat, P -- Faerman, A -- Bjorkhem, I -- Feinstein, E -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2087.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Quark Biotech, Inc., 10265 Carnegie Avenue, Cleveland, OH 44106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684813" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue ; Animals ; Bile Acids and Salts/biosynthesis ; Cholesterol/blood/*deficiency/metabolism/*physiology ; Desmosterol/*metabolism ; Female ; Gene Targeting ; Growth ; Humans ; Infertility ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Animal ; Nerve Tissue Proteins/*genetics/metabolism ; Oxidoreductases Acting on CH-CH Group Donors/*genetics/metabolism ; Phenotype ; Sex Characteristics ; Testis/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Scientific community. African study raises ethical issues (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2056.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684800" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Bacterial Agents/administration & dosage/therapeutic use ; Bioterrorism/prevention & control ; Clinical Trials as Topic/*ethics/standards ; Doxycycline/administration & dosage/therapeutic use ; Ethics Committees, Research ; Gentamicins/administration & dosage/*therapeutic use ; Humans ; Informed Consent ; Investigational New Drug Application ; Plague/*drug therapy ; Tanzania ; United States ; United States Food and Drug Administration/standards
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Conflict of interest. Zerhouni pledges review of NIH consulting in wake of allegations (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2046.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684792" target="_blank"〉PubMed〈/a〉
    Keywords: *Conflict of Interest ; *Consultants ; *Income ; National Institutes of Health (U.S.)/*ethics/organization & ; administration/standards ; *Research Personnel/economics/ethics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Genome sequencing. Cow ambles to the sequencing house (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2050.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684796" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle/*genetics ; Financing, Government ; *Genome ; *Research Support as Topic ; *Sequence Analysis, DNA ; United States ; United States Department of Agriculture/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    A gross indignity to humans (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolhekar, Aparna -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2070.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684804" target="_blank"〉PubMed〈/a〉
    Keywords: *Anatomy ; *Cadaver ; Human Body ; Humans ; Informed Consent ; *Plastics ; *Tissue Preservation ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Cell biology. In sex reversal, protein deterred by nuclear barrier (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sreenivasan, Aparna -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2050.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684795" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Amino Acid Sequence ; Animals ; Calmodulin/metabolism ; Cell Nucleus/*metabolism ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; Female ; Gonadal Dysgenesis, 46,XY/*etiology/genetics/metabolism ; Gonads/cytology/embryology/metabolism ; Humans ; Male ; Mice ; Mutation ; Nuclear Localization Signals ; Nuclear Pore/metabolism ; *Nuclear Proteins ; Protein Binding ; Sex-Determining Region Y Protein ; *Transcription Factors ; beta Karyopherins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Scientific community. Butler's samples spelled trouble for U.S. agencies (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2058.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684801" target="_blank"〉PubMed〈/a〉
    Keywords: Centers for Disease Control and Prevention (U.S.)/standards ; Military Medicine/standards ; Specimen Handling/*standards ; United States ; *United States Government Agencies ; *Yersinia pestis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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