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  • PANGAEA  (26,297)
  • Springer Nature  (9,365)
  • American Association for the Advancement of Science  (5,354)
  • Annual Reviews
  • 2000-2004  (41,978)
  • 1980-1984
  • 1935-1939
  • 1925-1929
  • 2003  (41,978)
Collection
Keywords
Publisher
Years
  • 2000-2004  (41,978)
  • 1980-1984
  • 1935-1939
  • 1925-1929
Year
  • 1
    Publication Date: 2015-08-18
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 2
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    PANGAEA
    In:  EPIC3Global Change Newsletter, Bremerhaven, PANGAEA, 53, pp. 10-13
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 3
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2015-01-19
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 4
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    PANGAEA
    In:  EPIC3HISKLIM 5, KNMI-publication 205., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 5
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    PANGAEA
    In:  EPIC3ATLAS Hydrographic, Doc.-Id.: HYD-DS2_ProductDescription_16c.doc Edition: 05.2003/ Version: 1.2 / Status: Final., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 6
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    PANGAEA
    In:  EPIC3jungsteinSITE: Informationen zur Neolithikum-Forschung, http://www.jungsteinsite.de/., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 7
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    PANGAEA
    In:  EPIC3Palaeogeography Palaeoclimatology Palaeoecology., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 8
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 9
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 10
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    PANGAEA
    In:  EPIC3Institute of Geography, University of Bern, Hallerstrasse 12Bern., Bremerhaven, PANGAEA, 3012
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 11
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    PANGAEA
    In:  EPIC3AWI/MARUM., Bremerhaven, PANGAEA
    Publication Date: 2019-07-16
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 12
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    PANGAEA
    In:  EPIC3CMDAC., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 13
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    PANGAEA
    In:  EPIC3WOCE International Project Office, WOCE Report No. 179/02., Southampton, UK., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 14
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 15
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 16
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 17
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 18
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    PANGAEA
    In:  EPIC3Personal information., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 19
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    PANGAEA
    In:  EPIC3Ice Ridging Information for Decision Making in Shipping Operations., Bremerhaven, PANGAEA
    Publication Date: 2019-07-16
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 20
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 21
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 22
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 23
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 24
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 25
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 26
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2014-11-28
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 27
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 28
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 29
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Bremerhaven, PANGAEA
    Publication Date: 2017-04-04
    Repository Name: EPIC Alfred Wegener Institut
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  • 30
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 31
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    PANGAEA
    In:  EPIC3Christian Haas, Alfred Wegener Institute, Bremerhaven, Germany., Bremerhaven, PANGAEA
    Publication Date: 2019-07-16
    Repository Name: EPIC Alfred Wegener Institut
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  • 32
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    PANGAEA
    In:  EPIC3RV LANCE 13/2003 cruise, Bremerhaven, PANGAEA, 23 p.
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 33
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    PANGAEA
    In:  EPIC3Ice Ridging Information for Decision Making in Shipping Operations., Bremerhaven, PANGAEA
    Publication Date: 2019-07-16
    Repository Name: EPIC Alfred Wegener Institut
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  • 34
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    PANGAEA
    In:  EPIC3AREX2003 cruise of the R.V. Oceania, Bremerhaven, PANGAEA, 12 p.
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 35
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    PANGAEA
    In:  EPIC3kk+w - digitale kartografie GmbH., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 36
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 37
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 38
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 39
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    PANGAEA
    In:  EPIC3Driesen + Kern GmbH., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 40
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    PANGAEA
    In:  EPIC3Driesen + Kern GmbH., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 41
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 42
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 43
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 44
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 45
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 46
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    PANGAEA
    In:  EPIC3Ecologia Aplicada, Bremerhaven, PANGAEA, 2(1), pp. 51-57
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 47
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    PANGAEA
    In:  EPIC3Abhandlungen des Naturwissenschaftlichen Vereins zu Bremen, Bremerhaven, PANGAEA, 45(2), pp. 191-210
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 48
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 49
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 50
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 51
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    PANGAEA
    In:  EPIC3Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 52
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    PANGAEA
    In:  EPIC3FIELAX Gesellschaft für wissenschaftliche Datenverarbeitung mbH, Bremerhaven, Bremerhaven, PANGAEA, 19 p.
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 53
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 54
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    PANGAEA
    In:  EPIC3FIELAX Gesellschaft für wissenschaftliche Datenverarbeitung mbH, Bremerhaven., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
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  • 55
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    PANGAEA
    In:  EPIC3Taylor, K C (2003): GISP2 Electrical conductivity measurements (Core B), doi:10.1594/PANGAEA.115683., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 56
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    PANGAEA
    In:  EPIC3ATLAS Hydrographic, Bremen, Doc.-Id.: SURF-API User Manual, File: SURF-API_User_Manual.doc, Edition: 07.2003 / Version: 1.0/ Status: Final., Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
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  • 57
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
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  • 58
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    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Publication Date: 2019-07-17
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  • 59
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 47-67 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Optical single transporter recording (OSTR) is an emerging technique for the fluorescence microscopic measurement of transport kinetics in membrane patches. Membranes are attached to transparent microarrays of cylindrical test compartments (TCs) ~0.1-100 mum in diameter and ~10-100 mum in depth. Transport across membrane patches that may contain single transporters or transporter populations is recorded by confocal microscopy. By these means transport of proteins through single nuclear pore complexes has been recorded at rates of 〈1 translocation/s. In addition to the high sensitivity in terms of measurable transport rates OSTR features unprecedented spatial selectivity and parallel processing. This article reviews the conceptual basis of OSTR and its realization. Applications to nuclear transport are summarized. The further development of OSTR is discussed and its extension to a diversity of transporters, including translocases and ATP-binding cassette (ABC) pumps, projected.
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  • 60
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 93-114 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Since mid-1990, with cloning and identification of several families of natural killer (NK) receptors, research on NK cells began to receive appreciable attention. Determination of structures of NK cell surface receptors and their ligand complexes led to a fast growth in our understanding of the activation and ligand recognition by these receptors as well as their function in innate immunity. Functionally, NK cell surface receptors are divided into two groups, the inhibitory and the activating receptors. Structurally, they belong to either the immunoglobulin (Ig)-like receptor superfamily or the C-type lectin-like receptor (CTLR) superfamily. Their ligands are either members of class I major histocompatibility complexes (MHC) or homologs of class I MHC molecules. The inhibitory form of NK receptors provides the protective immunity through recognizing class I MHC molecules with self-peptides on healthy host cells. The activating, or the noninhibitory, NK receptors mediate the killing of tumor or virally infected cells through their specific ligand recognition. The structures of activating and inhibitory NK cell surface receptors and their complexes with the ligands determined to date, including killer immunoglobulin-like receptors (KIRs) and their complexes with HLA molecules, CD94, Ly49A, and its complex with H-2Dd, and NKG2D receptors and their complexes with class I MHC homologs, are reviewed here.
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  • 61
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 161-182 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Recent years have witnessed a renaissance of fluorescence microscopy techniques and applications, from live-animal multiphoton confocal microscopy to single-molecule fluorescence spectroscopy and imaging in living cells. These achievements have been made possible not so much because of improvements in microscope design, but rather because of development of new detectors, accessible continuous wave and pulsed laser sources, sophisticated multiparameter analysis on one hand, and the development of new probes and labeling chemistries on the other. This review tracks the lineage of ideas and the evolution of thinking that have led to the actual developments, and presents a comprehensive overview of the field, with emphasis put on our laboratory's interest in single-molecule microscopy and spectroscopy.
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  • 62
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 135-159 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract The lamba integrase, or tyrosine-based family of site-specific recombinases, plays an important role in a variety of biological processes by inserting, excising, and inverting DNA segments. Flp, encoded by the yeast 2-mum plasmid, is the best-characterized eukaryotic member of this family and is responsible for maintaining the copy number of this plasmid. Over the past several years, structural and biochemical studies have shed light on the details of a common catalytic scheme utilized by these enzymes with interesting variations under different biological contexts. The emergence of new Flp structures and solution data provides insights not only into its unique mechanism of active site assembly and activity regulation but also into the specific contributions of certain protein residues to catalysis.
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    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 285-310 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract The past decade has witnessed increasingly detailed insights into the structural mechanism of the bacteriorhodopsin photocycle. Concurrently, there has been much progress within our knowledge pertaining to the lipids of the purple membrane, including the discovery of new lipids and the overall effort to localize and identify each lipid within the purple membrane. Therefore, there is a need to classify this information to generalize the findings. We discuss the properties and roles of haloarchaeal lipids and present the structural data as individual case studies. Lipid-protein interactions are discussed in the context of structure-function relationships. A brief discussion of the possibility that bacteriorhodopsin functions as a light-driven inward hydroxide pump rather than an outward proton pump is also presented.
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    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 375-397 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract G protein-coupled receptors (GPCRs) are integral membrane proteins that respond to environmental signals and initiate signal transduction pathways activating cellular processes. Rhodopsin is a GPCR found in rod cells in retina where it functions as a photopigment. Its molecular structure is known from cryo-electron microscopic and X-ray crystallographic studies, and this has reshaped many structure/function questions important in vision science. In addition, this first GPCR structure has provided a structural template for studies of other GPCRs, including many known drug targets. After presenting an overview of the major structural elements of rhodopsin, recent literature covering the use of the rhodopsin structure in analyzing other GPCRs will be summarized. Use of the rhodopsin structural model to understand the structure and function of other GPCRs provides strong evidence validating the structural model.
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    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 399-424 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract The coupling of high-performance mass spectrometry instrumentation with highly efficient chromatographic and electrophoretic separations has enabled rapid qualitative and quantitative analysis of thousands of proteins from minute samples of biological materials. Here, we review recent progress in the development and application of mass spectrometry-based techniques for the qualitative and quantitative analysis of global proteome samples derived from whole cells, tissues, or organisms. Techniques such as multidimensional peptide and protein separations coupled with mass spectrometry, accurate mass measurement of peptides from global proteome digests, and mass spectrometric characterization of intact proteins hold great promise for characterization of highly complex protein mixtures. Advances in chemical tagging and isotope labeling techniques have enabled quantitative analysis of proteomes, and highly specific isolation strategies have been developed aimed at selective analysis of posttranslationally modified proteins.
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    Annual Review of Materials Research 33 (2003), S. 557-579 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Combinatorial methods provide a means for accelerating the discovery of fuel cell catalysts. The first example of parallel fuel cell catalysts screening was an indirect method that used fluorescent chemosensors to detect changes in pH in proximity to electrocatalyst spots. Serial direct electrochemical methods have been developed that use voltammetry, chronoamperometry, and scanning electrochemical microscopy. An array fuel cell screens catalysts simultaneously, using high-performance fuel cell components. Heuristic models based on mechanistic and spectroscopic studies provide guidance for library development, and detailed studies of discovered catalysts can help to refine these models. The remaining challenges are the development of high throughput synthetic methods that can enable the use of discovery level and focus level screening. Until these synthetic methods are developed, a greater emphasis should be placed on smaller libraries with design of experiment strategies leveraged with informatics and data mining.
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    Annual Review of Materials Research 33 (2003), S. 503-555 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The past 10 years have witnessed a tremendous acceleration in research devoted to non-fluorinated polymer membranes, both as competitive alternatives to commercial perfluorosulfonic acid membranes operating in the same temperature range and with the objective of extending the range of operation of polymer fuel cells toward those more generally occupied by phosphoric acid fuel cells. Important requirements are adequate membrane mechanical strength at levels of functionalization (generally sulfonation) and hydration allowing high proton conductivity, and stability in the aggressive environment of a working fuel cell, in particular thermohydrolytic and chemical stability. This review provides an overview of progress made in the development of proton-conducting hydrocarbon and heterocyclic-based polymers for proton exchange and direct methanol fuel cells and describes the various approaches made to polymer modification/synthesis and salient properties of the materials formed, including those relating to proton transport and proton conductivity, e.g., water diffusion and electro-osmotic drag. The microstructure, deduced from small angle X-ray and neutron diffraction measurements of representative non-fluorinated polymers is compared with that of perfluorosulfonic acid membranes. Different degradation mechanisms and aging processes that can result in chemical and morphological alteration are considered, and recent characterization of membrane-electrode assemblies (MEAs) in direct methanol and hydrogen-air (oxygen) fuel cells completes this review of the state of the art. While several types of non-fluorinated polymer membrane have demonstrated lifetimes of 500-4000 h, only a limited number of systems exist that hold promise for long-term operation above 100oC.1
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    Annual Review of Fluid Mechanics 35 (2003), S. 1-10 
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
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    Annual Review of Fluid Mechanics 35 (2003), S. 45-62 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Drag reduction in wall-bounded flows can be achieved by transverse motions imposed by passive means, e.g., riblets, or by external forcing, such as wall oscillation or transverse traveling-wave excitation. In this article, we review possible physical mechanisms responsible for turbulent drag reduction and corresponding near-wall flow modification.
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    Annual Review of Fluid Mechanics 35 (2003), S. 89-111 
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract In this review we describe the aerodynamic problems that must be addressed in order to design a successful small aerial vehicle. The effects of Reynolds number and aspect ratio (AR) on the design and performance of fixed-wing vehicles are described. The boundary-layer behavior on airfoils is especially important in the design of vehicles in this flight regime. The results of a number of experimental boundary-layer studies, including the influence of laminar separation bubbles, are discussed. Several examples of small unmanned aerial vehicles (UAVs) in this regime are described. Also, a brief survey of analytical models for oscillating and flapping-wing propulsion is presented. These range from the earliest examples where quasi-steady, attached flow is assumed, to those that account for the unsteady shed vortex wake as well as flow separation and aeroelastic behavior of a flapping wing. Experiments that complemented the analysis and led to the design of a successful ornithopter are also described.
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    Annual Review of Fluid Mechanics 35 (2003), S. 135-167 
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The issue of the physical mechanism(s) that control the efficiency with which the density field in stably stratified fluid is mixed by turbulent processes has remained enigmatic. Similarly enigmatic has been an explanation of the numerical value of ~0.2, which is observed to characterize this efficiency experimentally. We review recent work on the turbulence transition in stratified parallel flows that demonstrates that this value is not only numerically predictable but also that it is expected to be a nonmonotonic function of the Richardson number that characterizes preturbulent stratification strength. This value of the mixing efficiency appears to be characteristic of the late-time behavior of the turbulent flow that develops after an initially laminar shear flow has undergone the transition to turbulence through an intermediate instability of Kelvin-Helmholtz type.
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    Annual Review of Fluid Mechanics 35 (2003), S. 373-412 
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Recent small-scale turbulence observations allow the mixing regimes in lakes, reservoirs, and other enclosed basins to be categorized into the turbulent surface and bottom boundary layers as well as the comparably quiet interior. The surface layer consists of an energetic wave-affected thin zone at the very top and a law-of-the-wall layer right below, where the classical logarithmic-layer characteristic applies on average. Short-term current and dissipation profiles, however, deviate strongly from any steady state. In contrast, the quasi-steady bottom boundary layer behaves almost perfectly as a logarithmic layer, although periodic seiching modifies the structure in the details. The interior stratified turbulence is extremely weak, even though much of the mechanical energy is contained in baroclinic basin-scale seiching and Kelvin waves or inertial currents (large lakes). The transformation of large-scale motions to turbulence occurs mainly in the bottom boundary and not in the interior, where the local shear remains weak and the Richardson numbers are generally large.
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    Annual Review of Fluid Mechanics 35 (2003), S. 469-496 
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Increasing urbanization and concern about sustainability and quality of life issues have produced considerable interest in flow and dispersion in urban areas. We address this subject at four scales: regional, city, neighborhood, and street. The flow is one over and through a complex array of structures. Most of the local fluid mechanical processes are understood; how these combine and what is the most appropriate framework to study and quantify the result is less clear. Extensive and structured experimental databases have been compiled recently in several laboratories. A number of major field experiments in urban areas have been completed very recently and more are planned. These have aided understanding as well as model development and evaluation.
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    Annual Review of Fluid Mechanics 35 (2003), S. 295-315 
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract It is classically assumed that the far field of a round turbulent jet discharging into quiescent fluid has a unique behavior characterized only by its momentum flux. However, there is now considerable evidence that different discharge conditions at the jet nozzle exit can give rise to very different far-field flows. Perhaps the most striking examples of these are the bifurcating and blooming jets produced by appropriate combinations of controlled axial and circumferential excitations at the nozzle exit. With the right excitations, a jet can be made to divide into two separate jets (bifurcating jet), each of which carries half the axial momentum and spreads in a manner similar to a single jet. Trifurcating jets can also be produced. Other excitations can produce blooming jets, in which the jet explodes into a shower of vortex rings, producing a far-field flow that is quite unlike a normal unexcited jet. Bifurcating and blooming jets exhibit much greater mixing than normal jets, suggesting possible applications in flow control. This article summarizes our work on bifurcating and blooming jets, which began with our discovery of them in the early 1980s and continued through the mid- 1990s. One of us (D.E.P.) continued exploration of flow control using excited jets, first at the McDonnell Douglas Corporation, and more recently at the Georgia Institute of Technology. The key to flow control is the manipulation of the large vortical structures in the near field of the jet. Ultimately this work, and that of others, led to full-scale testing of jet engine exhaust mixing control. There it was shown that the jet temperature downstream of the engine can be very significantly reduced by application of well-designed and easily implemented excitation at the engine discharge, thereby solving problems encountered during ground operations. Related jet control work by other investigators is included in this review.
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    Annual Review of Fluid Mechanics 35 (2003), S. 413-440 
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The recent progress in three-dimensional boundary-layer stability and transition is reviewed. The material focuses on the crossflow instability that leads to transition on swept wings and rotating disks. Following a brief overview of instability mechanisms and the crossflow problem, a summary of the important findings of the 1990s is given.
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    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 183-206 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Cyclooxygenases-1 and -2 (COX-1 and COX-2, also known as prostaglandin H2 synthases-1 and -2) catalyze the committed step in prostaglandin synthesis. COX-1 and -2 are of particular interest because they are the major targets of nonsteroidal antiinflammatory drugs (NSAIDs) including aspirin, ibuprofen, and the new COX-2-selective inhibitors. Inhibition of the COXs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces the incidence of fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. In this review, we examine how the structures of COXs relate mechanistically to cyclooxygenase and peroxidase catalysis and how alternative fatty acid substrates bind within the COX active site. We further examine how NSAIDs interact with COXs and how differences in the structure of COX-2 result in enhanced selectivity toward COX-2 inhibitors.
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    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 425-443 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Understanding the action of enzymes on an atomistic level is one of the important aims of modern biophysics. This review describes the state of the art in addressing this challenge by simulating enzymatic reactions. It considers different modeling methods including the empirical valence bond (EVB) and more standard molecular orbital quantum mechanics/molecular mechanics (QM/MM) methods. The importance of proper configurational averaging of QM/MM energies is emphasized, pointing out that at present such averages are performed most effectively by the EVB method. It is clarified that all properly conducted simulation studies have identified electrostatic preorganization effects as the source of enzyme catalysis. It is argued that the ability to simulate enzymatic reactions also provides the chance to examine the importance of nonelectrostatic contributions and the validity of the corresponding proposals. In fact, simulation studies have indicated that prominent proposals such as desolvation, steric strain, near attack conformation, entropy traps, and coherent dynamics do not account for a major part of the catalytic power of enzymes. Finally, it is pointed out that although some of the issues are likely to remain controversial for some time, computer modeling approaches can provide a powerful tool for understanding enzyme catalysis.
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    Annual Review of Materials Research 33 (2003), S. 263-288 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The use of low-energy electron microscopy (LEEM) to study reversible surface phase transitions is reviewed. Representative experiments are described that highlight the key advantages of LEEM: the ability to image surfaces in situ, at elevated temperature, with good spatial and temporal resolution. With these capabilities, the evolution of individual surface features-domains, facets, islands, steps, etc.-can be measured. Real-time and real-space imaging make LEEM a powerful tool for characterizing the thermodynamics and kinetics that govern surface phase transformations.
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    Annual Review of Materials Research 33 (2003), S. 233-261 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Anhydrous proton-conducting polymers usually consist of a more or less inert polymer matrix that is swollen with an appropriate proton solvent (in most cases, phosphoric acid). An outline of the different materials is provided, with a focus on PBI/H3PO4 blends that are currently most suitable for fuel cell applications. Also discussed are alternative concepts for fully polymeric materials, which establish proton conductivity as an intrinsic property using amphoteric heterocycles such as imidazole as a proton solvent. The development of some of the first polymers is described, and the fundamental relations between their material properties and conductivity are discussed. Closely related to this relatively new concept are mechanistic investigations focusing on intermolecular proton transfer and diffusion of (protonated) solvent molecules, the contributions of both transport processes to conductivity, and the dependence of these ratios on composition, charge carrier density, etc. Although the development of fully polymeric proton conductors is inseparably related to mechanistic considerations, relatively little attention has been paid to these concepts in the field of conventional membranes (hydrated ionomers, H3PO4-based materials). Consequently, their general relevance is emphasized, and according investigations are summarized to provide a more comprehensive picture of proton transport processes within proton exchange membranes.
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    Annual Review of Materials Research 33 (2003), S. 289-319 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The need to operate polymer electrolyte membrane (PEM) fuel cells at temperatures above 100oC, where the amount of water in the membrane is restricted, has provided much of the motivation for understanding the mechanisms of proton conduction at low degrees of hydration. Although experiments have not provided any direct information, numerous theoretical investigations have begun to provide the basis for understanding the mechanisms of proton conduction in these nano-phase-separated materials. Both the hydrated morphology and the nature of the confined water in the hydrophilic domains influence proton dissociation from the acidic sites (i.e., -SO3H), transfer to the water environment, and transport through the membrane. The following molecular processes are discussed in connection to their role in the conduction of protons in sulfonic acid-based polymer electrolyte membranes (PEMs): (a) local chemistry of the hydrophilic side chains; its effect on the dissociation of the proton and eventual stabilization (separation) of the proton in the water; (b) the presence of neighboring sulfonic acid groups on proton transfer; and (c) the effect of the distribution of the sulfonate groups on the transport of protons in the channels/pores of the membrane.
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    Annual Review of Materials Research 33 (2003), S. 333-359 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The structural and chemical parameters determining the formation and mobility of protonic defects in oxides are discussed, and the paramount role of high-molar volume, coordination numbers, and symmetry are emphasized. Symmetry also relates to the structural and chemical matching of the acceptor dopant. Y-doped BaZrO3-based oxides are demonstrated to combine high stability with high proton conductivity that exceeds the conductivity of the best oxide ion conductors at temperatures below about 700oC. The unfavorably high grain boundary impedances and brittleness of ceramics have been reduced by forming solid solutions with small amounts of BaCeO3, and an initial fuel cell test has demonstrated that proton-conducting electrolytes based on Y-doped BaZrO3 provide alternatives for separator materials in solid oxide fuel cells (SOFCs). These materials have the potential to operate at lower temperatures compared with those of conventional SOFCs, and the appearance of chemical water diffusion across the electrolyte at typical operation temperatures (T = 500-800oC) allows the use of dry methane as a fuel.
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    Annual Review of Materials Research 33 (2003), S. 321-331 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Recently, a number of papers about direct oxidation of methane and hydrocarbon in solid oxide fuel cells (SOFC) at relatively low temperatures (about 700oC) have been published. Even though the conversion of almost dry CH4 at 1000oC on ceramic anodes was demonstrated more than 10 years ago, the reports about high-current densities for methane oxidation at such low temperatures are indeed surprising. Several papers indicate that a catalytic effect (due to the mixed ionic and electronic conductivity) of CeO2-x is partially responsible for this effect. However, this seems to contradict previous reports, and thus this issue deserves further analysis.
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    Annual Review of Materials Research 33 (2003), S. 383-417 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The emphasis in this short review is to describe the materials issues involved in the development of present thermal barrier coatings and the advances necessary for the next generation, higher temperature capability coatings.
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    Annual Review of Materials Research 33 (2003), S. 361-382 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Several recent experimental and numerical investigations have contributed to the improved understanding of the electrochemical mechanisms taking place at solid oxide fuel cell (SOFC) cathodes and yielded valuable information on the relationships between alterable parameters (geometry/material) and the cathodic polarization resistance. Efforts to reduce the polarization resistance in SOFCs can benefit from these results, and some important aspects of the corresponding studies are reviewed. Experimental results, particularly measurements using geometrically well-defined Sr-doped LaMnO3 (LSM) cathodes, are discussed. In regard to simulations, the different levels of sophistication used in SOFC electrode modeling studies are summarized and compared. Exemplary simulations of mixed conducting cathodes that show the capabilities and limits of different modeling levels are described.
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    Annual Review of Materials Research 33 (2003), S. 419-501 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This account reviews the discovery, synthesis, properties, and the latest research advances of carbon nanotubes developed over the past 12 years. Because of their remarkable electronic and mechanical properties, carbon nanotubes are unique and exciting. The field has been developed rapidly, and the number of publications per year is increasing almost exponentially. Various technological applications are likely to arise using nanotubes for fabrication of flat panel displays, gas storage devices, toxic gas sensors, Li+ batteries, robust and lightweight composites, conducting paints, electronic nanodevices, etc. Further experimental and theoretical research is still necessary so that novel technologies will become a reality in the early twenty-first century.
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    Annual Review of Materials Research 33 (2003), S. 215-231 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This paper presents a review of atomic-scale defects (planar defects and dislocations) analysis using atom probe (AP) and field ion microscopy (FIM). A large part of the discussion is dedicated to the first atomic-scale observation of a Cottrell atmosphere by a three-dimensional atom probe method (3DAP). The nanoscale boron segregation to line dislocations and planar defects in a B2-ordered FeAl (40 at.%Al) is imaged in three dimensions of the real space. The boron-enriched Cottrell atmosphere is imaged in the close vicinity of an edge 001〉 dislocation as a rod 3 nm in diameter, around to the dislocation line.
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    Annual Review of Astronomy and Astrophysics 41 (2003), S. 15-56 
    ISSN: 0066-4146
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Notes: The galaxies of the Local Group serve as important laboratories for understanding the physics of massive stars. Here I discuss what is involved in identifying various kinds of massive stars in nearby galaxies: the hydrogen-burning O-type stars and their evolved He-burning evolutionary descendants, the luminous blue variables, red supergiants, and Wolf-Rayet stars. Primarily I review what our knowledge of the massive star population in nearby galaxies has taught us about stellar evolution and star formation. I show that the current generation of stellar evolutionary models do well at matching some of the observed features and provide a look at the sort of new observational data that will provide a benchmark against which new models can be evaluated.
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    Annual Review of Astronomy and Astrophysics 41 (2003), S. 169-189 
    ISSN: 0066-4146
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Notes: The first law of theoretical physics, the Newtonian law of gravitation, relies on the concept of action at a distance. The success of this law led to the concept being applied to electricity and magnetism, which were next to be explored in depth. Here the action at a distance had a limited success and ultimately had to be abandoned in favor of the increasingly more popular field theory. Nevertheless, in the 1940s, an attempt was made to revive the concept of action at a distance in a relativistically invariant way by Wheeler & Feynman (1945, 1949). It inspired a series of investigations in both electrodynamics and gravity in which the field concept was not used but the interaction was described as taking place directly between particles. As it impinged very intimately on cosmology, Hoyle was keenly interested in it. This review discusses the work by Hoyle, the author, and others on the development of electrodynamics and gravitation as direct particle theories. In this review, the author discusses how the work was started and went through stages of increasing sophistication, e.g., extending the Wheeler-Feynman electrodynamics to curved spacetime, its consequences in different cosmologies, and the issues arising from its quantization. The resolution of ultraviolet divergences in quantum electrodynamics is also briefly discussed. The parallel development of a Machian theory of gravitation followed the lead from electrodynamics. In both theories one sees a strong link between the large-scale structure of the universe and local physics, as might be expected from an action-at-a-distance framework.
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    Annual Review of Astronomy and Astrophysics 41 (2003), S. 343-390 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Notes: Targeted laboratory astrophysics measurements are being conducted to address the needs of X-ray astronomy. The measurements are producing large sets of reliable atomic data, which include ionization and recombination cross sections for charge balance calculations, as well as line lists, excitation cross sections, and dielectronic recombination rates for interpreting X-ray line formation. Additional experiments focus on resolving specific puzzles posed by astrophysical observations, as well as on calibrating existing and developing new X-ray line diagnostics. We discuss the types of data produced and illustrate how the laboratory measurements support such missions as ASCA, EUVE, Chandra, XMM, and ASTRO-E2.
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    Annual Review of Astronomy and Astrophysics 41 (2003), S. 517-554 
    ISSN: 0066-4146
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Notes: Photoionized clouds are ubiquitous. They define the endpoints of stellar evolution (H II regions and planetary nebulae), constitute the interstellar and intergalactic media, and are found in high redshift quasars and star-forming galaxies. The spectra of these objects are dominated by emission lines that are sensitive to details of the emitting gas. These details include the microscopic atomic processes that cause the gas to glow; the density, composition, and temperature of the gas; and the radiation field of the central continuum source. Large-scale numerical codes that incorporate all the needed physics and predict the observed spectrum have become essential tools in understanding these objects. This article reviews the current status of the numerical simulations of emitting gas, with particular emphasis on photoionized clouds and the underlying simplicity that governs these nebulae; the types of questions that can be addressed by today's codes; and the big questions that remain unanswered.
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  • 91
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    Annual Review of Fluid Mechanics 35 (2003), S. 169-182 
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The modern study of a crowd as a flowing continuum is a recent development. Distinct from a classical fluid because of the property that a crowd has the capacity to think, interesting new physical ideas are involved in its study. An appealing property of a crowd in motion is that the nonlinear, time-dependent, simultaneous equations representing a crowd are conformably mappable. This property makes many interesting applications analytically tractable. In this review examples are given in which the theory has been used to provide possible assistance in the annual Muslim Hajj, to understand the Battle of Agincourt, and, surprisingly, to locate barriers that actually increase the flow of pedestrians above that when there are no barriers present. Modern developments may help prevent some of the approximately two thousand deaths that annually occur in accidents owing to crowding.The field of crowd motion, that is, the field of "thinking fluids," is an intriguing area of research with great promise.
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    Annual Review of Fluid Mechanics 35 (2003), S. 267-293 
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The recent avalanche of research activity in the field of granular matter has yielded much progress. The use of state-of-the-art (and other) computational and experimental methods has led to the discovery of new states and patterns and enabled detailed tests of theories and models. The application of statistical mechanical methods and phenomenology has contributed to the understanding of the microscopic a nd macroscopic properties of granular systems. Some previously open problems seem to be solved. Fluidized granular systems (rapid granular flows), recently referred to as granular gases, are often modeled by hydrodynamic equations of motion, some of which are based on systematic expansions applied to the pertinent Boltzmann equation. The undeniable success of granular hydrodynamics is somewhat surprising in view of the lack of scale separation in these systems and the neglect of certain correlations in most derivations of the hydrodynamic equations. Microstructures have been recognized as key features of granular gases; explanations for their existence have been proposed, and many of their properties elucidated. Granular-gas multistability can often be traced back to microstructure dynamics. In spite of these and other impressive advances, this field still poses serious challenges.
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    Annual Review of Fluid Mechanics 35 (2003), S. 317-340 
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Recent advances in achieving textbook multigrid efficiency for fluid simulations are presented. Textbook multigrid efficiency is defined as attaining the solution to the governing system of equations in a computational work that is a small multiple of the operation counts associated with discretizing the system. Strategies are reviewed to attain this efficiency by exploiting the factorizability properties inherent to a range of fluid simulations, including the compressible Navier-Stokes equations. Factorizability is used to separate the elliptic and hyperbolic factors contributing to the target system; each of the factors can then be treated individually and optimally. Boundary regions and discontinuities are addressed with separate (local) treatments. New formulations and recent calculations demonstrating the attainment of textbook efficiency for aerodynamic simulations are shown.
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    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 1-25 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Mass spectrometry has provided a powerful method for monitoring hydrogen exchange of protein backbone amides with deuterium from solvent. In comparison to popular NMR approaches, mass spectrometry has the advantages of higher sensitivity, wider coverage of sequence, and the ability to analyze larger proteins. Proteolytic fragmentation of proteins following the exchange reaction provides moderate structural resolution, in some cases enabling measurements from single amides. The technique has provided new insight into protein-protein and protein-ligand interfaces, as well as conformational changes during protein folding or denaturation. In addition, recent studies illustrate the utility of hydrogen exchange mass spectrometry toward detecting protein motions relevant to allostery, covalent modifications, and enzyme function.
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    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 27-45 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Cations are bound to nucleic acids in a solvated state. High-resolution X-ray diffraction studies of oligonucleotides provide a detailed view of Mg2+, and occasionally other ions bound to DNA. In a survey of several such structures, certain general observations emerge. First, cations bind preferentially to the guanine base in the major groove or to phosphate group oxygen atoms. Second, cations interact with DNA most frequently via water molecules in their primary solvation shell, direct ion-DNA contacts being only rarely observed. Thus, the solvated ions should be viewed as hydrogen bond donors in addition to point charges. Finally, ion interaction sites are readily exchangeable: The same site may be occupied by any ion, including spermine, as well as by a water molecule.
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    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 69-92 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Although protein function is thought to depend on flexibility, precisely how the dynamics of the molecule and its environment contribute to catalytic mechanisms is unclear. We review experimental and computational work relating to enzyme dynamics and function, including the role of solvent. The evidence suggests that fast motions on the 100 ps timescale, and any motions coupled to these, are not required for enzyme function. Proteins where the function is electron transfer, proton tunneling, or ligand binding may have different dynamical dependencies from those for enzymes, and enzymes with large turnover numbers may have different dynamical dependencies from those that turn over more slowly. The timescale differences between the fastest anharmonic fluctuations and the barrier-crossing rate point to the need to develop methods to resolve the range of motions present in enzymes on different time- and lengthscales.
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    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 115-133 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract The OB-fold domain is a compact structural motif frequently used for nucleic acid recognition. Structural comparison of all OB-fold/nucleic acid complexes solved to date confirms the low degree of sequence similarity among members of this family while highlighting several structural sequence determinants common to most of these OB-folds. Loops connecting the secondary structural elements in the OB-fold core are extremely variable in length and in functional detail. However, certain features of ligand binding are conserved among OB-fold complexes, including the location of the binding surface, the polarity of the nucleic acid with respect to the OB-fold, and particular nucleic acid-protein interactions commonly used for recognition of single-stranded and unusually structured nucleic acids. Intriguingly, the observation of shared nucleic acid polarity may shed light on the longstanding question concerning OB-fold origins, indicating that it is unlikely that members of this family arose via convergent evolution.
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    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 469-492 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract The observation of liquid-liquid immiscibility in cholesterol-phospholipid mixtures in monolayers and bilayers has opened a broad field of research into their physical chemistry. Some mixtures exhibit multiple immiscibilities. This unusual property has led to a thermodynamic model of "condensed complexes." These complexes are the consequence of an exothermic, reversible reaction between cholesterol and phospholipids. In this quantitative model the complexes are sometimes concentrated in a separate liquid phase. The phase separation into a complex-rich phase depends on membrane composition and intensive variables such as temperature. The properties of defined cholesterol-phospholipid mixtures provide a conceptual foundation for the exploration of a number of aspects of the biophysics and biochemistry of animal cell membranes.
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    Annual Review of Materials Research 33 (2003), S. 29-54 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Interfacial adhesion plays a central role in a number of technologically important applications. Quantitatively measuring the adhesion of an interface and understanding the processes and controlling mechanisms of energy dissipation is not always a straightforward task, however. It is often not enough to know that an interface in a particular application is weak and prone to failure because it can be difficult to accurately recreate that interface with a bulk specimen and derive a meaningful adhesion value. Rather, a fundamental knowledge of the processes that actually contribute to the interfacial strength is important, so that, when bulk specimens are prepared, care can be taken to eliminate energy-absorbing processes that are not present in the actual application. Accordingly, this paper reviews some of the literature highlighting the contributing factors that control interfacial adhesion. The focus is on those models that describe the detailed mechanisms of the energy-absorbing processes and on some of the experimental data that illustrates those models.
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    Annual Review of Materials Research 33 (2003), S. 1-27 
    ISSN: 1531-7331
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The hydrogen economy is fast approaching as petroleum reserves are rapidly consumed. The fuel cell promises to deliver clean and efficient power by combining hydrogen and oxygen in a simple electrochemical device that directly converts chemical energy to electrical energy. Hydrogen, the most plentiful element available, can be extracted from water by electrolysis. One can imagine capturing energy from the sun and wind and/or from the depths of the earth to provide the necessary power for electrolysis. Alternative energy sources such as these are the promise for the future, but for now they are not feasible for power needs across the globe. A transitional solution is required to convert certain hydrocarbon fuels to hydrogen. These fuels must be available through existing infrastructures such as the natural gas pipeline. The present review discusses the catalyst and adsorbent technologies under development for the extraction of hydrogen from natural gas to meet the requirements for the proton exchange membrane (PEM) fuel cell. The primary market is for residential applications, where pipeline natural gas will be the source of H2 used to power the home. Other applications including the reforming of methanol for portable power applications such as laptop computers, cellular phones, and personnel digital equipment are also discussed. Processing natural gas containing sulfur requires many materials, for example, adsorbents for desulfurization, and heterogeneous catalysts for reforming (either autothermal or steam reforming) water gas shift, preferential oxidation of CO, and anode tail gas combustion. All these technologies are discussed for natural gas and to a limited extent for reforming methanol.
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