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  • 1
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    NRC panel to propose station institute (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-09-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1999 Dec 17;286:2251.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11542666" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): National Academy of Sciences (U.S.) ; Research/organization & administration/*trends ; United States ; United States National Aeronautics and Space Administration/*organization & ; administration
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Neuroscience. An antibiotic to treat Alzheimer's? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: An antibiotic once used to treat traveler's diarrhea might battle Alzheimer's disease as well, researchers announced here last week at the Society for Neuroscience's annual meeting. The drug dissolves Alzheimer's-like plaques in mouse brains, apparently by trapping the copper and zinc that stud these deposits. A clinical trial to test whether the drug helps people with Alzheimer's is already under way.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, L -- New York, N.Y. -- Science. 2000 Nov 17;290(5495):1273-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11185394" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alzheimer Disease/*drug therapy/metabolism/pathology ; Amyloid beta-Peptides/*metabolism ; Animals ; Brain/drug effects/metabolism/pathology ; Clinical Trials, Phase II as Topic ; Clioquinol/metabolism/pharmacology/*therapeutic use ; Copper/metabolism/pharmacology ; Humans ; Mice ; Plaque, Amyloid/*drug effects/metabolism ; Zinc/metabolism/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Neuroscience meeting draws crowds, gripes, loyalty (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: Preparing for their 30th conference, neuroscientists contemplate how the field--and the annual meeting--has grown. With the Society for Neuroscience meeting routinely packing in about 25,000 people, some neuroscientists complain about long lines and related inconveniences. But others say that the best reason to go to the meeting is precisely because it's so huge and integrates the ever-growing number of subdisciplines in the field.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, L -- New York, N.Y. -- Science. 2000 Oct 27;290(5492):698-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11184193" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Congresses as Topic ; Humans ; *Neurosciences ; *Research ; *Societies, Scientific/organization & administration ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Laboratory animals. Researchers pained by effort to define distress precisely (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: The U.S. Department of Agriculture requested comments earlier this year to help it decide whether to adopt a formal definition of "distress" as part of its responsibilities under the Animal Welfare Act. But the 2600 pieces of advice it received during a 4-month period that ended earlier this month suggest that its job won't be easy. The comments highlight a deep split between animal activists, who see the potential new regulations as a step toward eliminating all painful procedures, and most researchers, who say that the present system is working well and that no major changes are needed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 2000 Nov 24;290(5496):1474-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11185495" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Animal Experimentation ; *Animal Welfare/legislation & jurisprudence ; Animals ; *Animals, Laboratory ; *Government Regulation ; Pain/veterinary ; *Research ; Stress, Physiological/*veterinary ; United States ; *United States Department of Agriculture/legislation & jurisprudence
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Genomics and gene therapy. Artificial chromosomes coming to life (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: One of the biggest obstacles to gene therapy is the delivery of the therapeutic gene to the target tissue so that it is appropriately expressed. In his Perspective, Willard looks at the potential advantages of using a human artificial chromosome to maintain expression of a therapeutic gene and discusses some of the hurdles yet to be overcome before this gene delivery system can be tried out in the clinic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willard, H F -- New York, N.Y. -- Science. 2000 Nov 17;290(5495):1308-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Center for Human Genetics at Case Western Reserve University and the Research Institute of Universi Hospitals of Cleveland, Cleveland, OH 44106, USA. hfw@po.CWRU.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11185406" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Centromere/chemistry/genetics/physiology ; *Chromosomes, Artificial, Human/genetics/physiology/ultrastructure ; Chromosomes, Artificial, Mammalian ; DNA, Satellite/genetics ; Gene Expression ; Gene Transfer Techniques ; *Genetic Therapy ; Genetic Vectors ; Humans ; Mice
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Neurobiology. A stargazer foretells the way to the synapse (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: How do AMPA receptors that are made in the cytoplasm of excitatory neurons travel to and become localized in the distant postsynaptic membranes of dendrites? Nakagawa and Sheng, in a Perspective, suggest that the answer may lie in the stargazin protein that has now been found to interact with AMPA receptors, guiding them to the postsynaptic membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakagawa, T -- Sheng, M -- New York, N.Y. -- Science. 2000 Dec 22;290(5500):2270-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11188726" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Calcium Channels/chemistry/genetics/*metabolism ; Cell Membrane/metabolism ; Cerebellum/cytology/*metabolism ; Dendrites/metabolism ; Mice ; Mice, Mutant Strains ; Models, Biological ; Nerve Tissue Proteins/metabolism ; Neurons/*metabolism ; Protein Binding ; Protein Transport ; Receptors, AMPA/*metabolism ; Synapses/metabolism ; Synaptic Membranes/*metabolism ; Synaptic Transmission
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Profile. For 'father' of abortion drug, vindication at last (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, M -- New York, N.Y. -- Science. 2000 Oct 6;290(5489):39.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11183145" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortifacient Agents, Steroidal/*history ; Aging/drug effects ; Dehydroepiandrosterone/history/pharmacology ; *Drug Approval ; Drug Industry ; Female ; France ; History, 20th Century ; Humans ; Mifepristone/*history ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Development. Survival is impossible without an editor (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: RNA editing is a fascinating phenomenon that is found in both animal and plant cells. By converting an adenosine base to an inosine (which behaves like guanosine) in RNA that has already been transcribed, certain RNA sequences (and hence the amino acids they encode) are altered. In a Perspective, Keegan, Gallo and O'Connell explore new results showing that activity of the editing enzyme ADAR1 is crucial for normal development of red blood cells in mouse embryos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keegan, L P -- Gallo, A -- O'Connell, M A -- New York, N.Y. -- Science. 2000 Dec 1;290(5497):1707-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. liam.keegan@hgu.mrc.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11186391" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine/metabolism ; Adenosine Deaminase/chemistry/*genetics/*metabolism ; Animals ; Base Pairing ; Central Nervous System/metabolism ; Chimera ; Drosophila/genetics/metabolism ; Embryo, Mammalian/cytology ; Embryo, Nonmammalian ; *Erythropoiesis ; Gene Dosage ; Hematopoietic Stem Cells/cytology/enzymology ; Inosine/metabolism ; Liver/metabolism ; Mice ; Mutation ; Phenotype ; Protein Structure, Tertiary ; *RNA Editing ; RNA Precursors/metabolism ; RNA, Double-Stranded/metabolism ; RNA-Binding Proteins ; Receptors, AMPA/genetics ; Stem Cells/cytology/enzymology ; Teratoma/genetics/pathology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Marine ecology. Warmer waters more deadly to coral reefs than pollution (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: Contrary to conventional wisdom, warmer ocean waters are a greater threat to coral reefs than local environmental insults. That assessment comes from a new scientific report released this week that documents a sudden and steep jump in damage stemming from the 1997-98 El Nino-La Nina event.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, D -- New York, N.Y. -- Science. 2000 Oct 27;290(5492):682-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11184189" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Climate ; Cnidaria/*physiology ; *Ecosystem ; Fishes ; Industry ; Oceans and Seas ; Temperature ; Water Pollution
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    A benefit of being big (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schimpf, D -- New York, N.Y. -- Science. 2000 Oct 20;290(5491):453.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11183763" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adaptation, Physiological ; *DNA Transposable Elements ; *Genome, Plant ; Plant Development ; Plants/genetics ; Temperature
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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