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  • Articles  (4)
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  • mice  (3)
  • evolution
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  • Springer  (4)
  • American Institute of Physics
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  • 1995-1999  (4)
  • 1965-1969
  • 1996  (4)
  • Psychology  (4)
  • 1
    ISSN: 1573-3297
    Keywords: Vocalizations ; ultrasounds ; development ; newborn ; mice ; NZB/BINJ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Two kinds of vocalizations are produced by newborn mice: whistles (between 50 and 150 ms in length), having a narrow bandwidth in each strain that ranges from 30 to 90 kHz; and clicks, which are shorter (about 1 ms) and have a larger bandwidth. These vocalizations were individually recorded in 1-day-old pups from seven inbred strains of laboratory mice, at two temperatures (23±0.5 and 15±0.5°C). The numbers of clicks and whistles were counted under these two conditions. Moreover, the length and frequencies at the beginning, apex, and end of the whistles were measured during the 15°C condition. Correlations, including several components—additivity, epistasis (between homozygous loci), and maternal environment—were calculated between the characteristics of the whistles during the 15°C condition. Clicks and whistles were also counted from 1 to 8 days of age during the 15°C condition. The numbers of clicks and whistles were age dependent, with a decrease from day 1 to day 8 for the clicks and a consistent production of whistles. A quantitative genetic analysis was also performed on the 1-day-old pups from the mendelian generations produced by the inbred strains most contrasting for the number of whistles produced in the cold condition: NZB/BINJ and CBA/H. The heterozygous genotype of the mother induced an increment of the number of whistles. Moreover, a significant part of the additive variance was suspected from the first design, and found with the second one, for this variable. Quantitative genetic analysis showed significant dominance and epistasis between homozygous loci and homozygous and heterozygous loci. This points to multigenic correlates for the number of whistles in this population. The significant additive values for all the variables recorded during the 15±0.5°C condition and for the number of whistles produced during the 23±0.5°C condition are compatible with an effect the indicates neither directional nor stabilizing selection. This results is examined in the light of the multichannel sensorial process implicated in maternal behavior in mice.
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  • 2
    ISSN: 1573-3297
    Keywords: Heterosis ; nest-building behavior ; Mus domesticus ; selection ; evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Replicate high-selected, control, and low-selected lines were crossed at generation 46 of bidirectional selection for thermoregulatory nest-building behavior. Previous analysis of the lines at their limits had revealed multiple responses to uniform selection, where each of the four selected lines responded differently to reverse selection (Laffan, 1989). The reciprocal F1 crosses showed significant heterosis for nest-building behavior compared to the contemporaneous generations of the parental lines. This pattern of heterosis in all three crosses is consistent with the finding that nest-building behavior in each of the four replicate lines had a different genetic basis, in spite of the phenotypic similarity between the two replicate lines in the high and low direction of nesting. This heterosis effect and the larger number of young weaned in all three crosses compared to their respective contemporaneous generation of the parental lines also support earlier findings that larger nests are closely related to fitness.
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  • 3
    ISSN: 1573-3297
    Keywords: Gene mapping ; LS and SS ; pharmacogenetics ; quantitative genetics ; mice ; alcohol action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract We are mapping the genes (quantitative trait loci or QTLs) that are responsible for individual differences in ethanol sensitivity, measured as the duration of loss of righting reflex (LORR) and blood ethanol concentrations upon recovery of the righting reflex (BEC). The Long-Sleep (LS) and Short-Sleep (SS) selected lines of mice manifest an 18-fold difference in LORR and serve as a rodent model for ethanol sensitivity. The LS x SS recombinant inbred (RI) series, developed from LS and SS lines, are an important resource for QTL mapping of ethanol-related responses. The current report summarizes the initial QTL analysis of LORR and BEC in the LS x SS strains and compares the results of correlational analysis with an interval-mapping approach. The data provide strong evidence for QTLs that influence ethanol sensitivity on mouse chromosomes 1 and 2 and possible QTLs on chromosomes 1, 3, 4, 5, 6, 7, 12, 13, 16, and 18. These results are compared to those from an F2 cross which confirms QTLs on chromsomes 1, 2, 4, and 18.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Behavior genetics 26 (1996), S. 471-476 
    ISSN: 1573-3297
    Keywords: Agonistic behavior ; offense ; candidate genes ; Y chromosome ; Sry ; mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract It is well established that the agonistic behavior of offense in mice is heritable. However, few genes have been identified or mapped for offense. For segments of chromosomes with effects on offense, a positional candidate strategy can be used to find such genes. This approach is illustrated for the effect of the male specific part (nonpseudoautosomal region; NPAR) of the mouse Y chromosome on offense. It is proposed that a positional candidate for this effect isSry. The Sry protein is a transcription factor. Its mRNA is expressed in fetal and adult brain. Its protein binds to response elements in the 5′ end of the aromatase and theFral genes. Each of these genes has potential effects on several brain neurotransmitter systems involved in offense. The NPAR Y chromosomes of several pairs of inbred strains have differential effects on offense. This hypothesis would be tested by sequencingSry for some of these pairs of strains.
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