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  • Chemistry  (10.155)
  • T1-995  (1.126)
  • Organic Chemistry  (917)
  • FLUID MECHANICS AND HEAT TRANSFER  (831)
  • Inorganic Chemistry
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  • R5-920
  • Statistical Physics
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  • 1
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    Millimeter-Wave Radio-over-Fiber Links based on Mode-Locked Laser Diodes (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: Radio communications in the range of 60 GHz enable multi-Gigabit/s network access in indoor environments. Due to the propagation characteristics of such signals only very short range radio transmission is feasible. In order to distribute these signals across large distances, analog transmission over optical fiber is considered. In this work, mode-locked laser diodes serve as optoelectronic oscillators for the generation of such signals. Their system-relevant properties are studied in detail.
    Schlagwort(e): T1-995 ; millimeter wave communications ; mode-locked lasers ; wireless personal area networks ; radio-over-fiber ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 2
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    Herstellung und Charakterisierung mechanisch flexibler organischer Solarzellen durch Flüssigprozessierung (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: This document presents the development and optoelectronic analysis of a flexible electrode system. The focus is the application of all functional layers out of solution to enable a cost effective processing with large area print and coating techniques. Moreover, the mechanical stability of the electrode system and the complete solar cell is investigated by tensile tests.
    Schlagwort(e): T1-995 ; organische Halbleiter ; printed electronics ; flexible electronics ; druckbare Elektronik ; Photovoltaik ; flexible Elektronik photovoltaic ; organic semiconductor ; solar cell ; Solarzelle ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 3
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    Electrospun and Electrosprayed Formulations for Drug Delivery (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Schlagwort(e): R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 4
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    Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Schlagwort(e): R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 5
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    Entwicklung und vergleichende Bewertung einer bildbasierten Markierungslichtsteuerung für Kraftfahrzeuge (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: In automotive lighting technology there have been taken place intense research efforts in the field of adaptive lighting systems to provide a flexible luminance intensity distribution optimally adapted to the situational prevailing traffic and atmospheric situation in the last recent years.This paper describes the development and comparative evaluation of an image-based control system for a marking light approach designed for motor vehicles.
    Schlagwort(e): T1-995 ; Bildverarbeitung ; Probandenstudie ; Lichtbasiertes Fahrerassistenzsystem ; Erkennbarkeitsentfernung ; Dynamische Zustandsschätzung ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 6
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    Neuroimmune Interface in Health and Diseases (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Schlagwort(e): R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 7
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    Modellbasierte Entwicklung eines aktiven Sicherheitssystems für elektrifizierte Fahrräder (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: The electrical energy on electrified bicycles offers new functional possibilities such as an active safety system to assist the rider during the braking process. This work shows the technical feasibility of such a system by presenting a rideable prototype. The so-called braking dynamics assistance system prevents the cyclist from both front wheel lockup and rollover (along the vehicle’s transverse axis).
    Schlagwort(e): T1-995 ; Elektrofahrrad ; safety system ; Fahrdynamik ; Electric bicycle ; vehicle dynamics ; model-based design ; Verkehrssicherheit ; road safety ; Modellbasierte Entwicklung ; Sicherheitssystem ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 8
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    Recursos Críticos: história da cooperação técnica Opas-Brasil em recursos humanos para a saúde (1975-1988) (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Um livro valioso, que analisa com clareza o papel fundamental dos recursos humanos para a saúde e o desenvolvimento, bem como o contexto e o impacto da reforma sanitária e a relação entre as iniciativas internacionais, nacionais e locais em prol da mudança dos serviços de saúde. Além de examinar os antecedentes e os principais atores da área de recursos humanos e explicar com detalhes as negociações que visavam transformar em prioridade nacional a formação de recursos humanos e a distribuição dos trabalhadores de saúde no território, Recursos Críticos está apoiado em uma sólida pesquisa bibliográfica, testemunhos fascinantes e análise original, que fazem da obra uma contribuição significativa no campo da memória da saúde pública e uma ferramenta indicativa de perspectivas de futuro para trabalhadores na área da saúde. É uma pesquisa histórica de grande qualidade, voltada para a análise da cooperação Opas-Brasil, e um incentivo à realização de novos estudos sobre as interfaces entre a atuação de agências internacionais e os interesses nacionais, partindo do conceito de arenas ou espaços de negociação.
    Schlagwort(e): R5-920 ; Brasil ; Recursos humanos em saúde ; Planos e programas de saúde ; Cooperação técnica ; Organização Pan-Americana da Saúde ; bic Book Industry Communication::M Medicine
    Sprache: Portugiesisch
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  • 9
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    Entwicklung einer Plattform zur individuellen Ansteuerung von Mikroventilen und Aktoren auf der Grundlage eines Phasenüberganges zum Einsatz in der Mikrofluidik (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: Im Rahmen dieser Arbeit wurde eine Plattform zur individuellen Ansteuerung einer Vielzahl thermisch aktivierter Mikroventile und aktoren, auf Grundlage eines Phasenüberganges, zum Einsatz in der Mikrofluidik entwickelt. Ventile dienen dazu den Fluidstrom in komplexen mikrofluidischen Systemen, aus Einsatzgebieten wie der Biologie, Chemie oder Biotechnologie, zu manipulieren. Mit steigender Komplexität der Mikrosysteme steigt auch die Anzahl der benötigten, individuell steuerbaren Mikroventile.
    Schlagwort(e): T1-995 ; thermisch ; Mikrofluidik ; Mikroventile ; Phasenübergang ; Mikroaktoren ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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  • 10
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    Inhibiting PARP as a Strategic Target in Cancer (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Schlagwort(e): R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 11
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    International Perspectives on Health and Safety Among Dairy Workers Challenges, Solutions and the Future (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Schlagwort(e): R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 12
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    From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Schlagwort(e): R5-920 ; gluten-related disorders；celiac disease；gluten intolerance ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 13
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    Microglia in Health and Disease: A Unique Immune Cell Population (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Schlagwort(e): R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 14
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    Energieoptimale Fahrdynamikregelung mehrmotoriger Elektrofahrzeuge (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Within the scope of this work a generic approach to the control of multiple-drive electric vehicles is evolved. An analysis of the overall system with respect to the exploitable degrees of freedom for wheel torque control reveals that several possible solutions for distributing wheel torque exist in certain driving situations. This characteristic of over-actuated systems is exploited in order to pursue further subordinate objectives from from a control perspective.
    Schlagwort(e): T1-995 ; mehrmotoriger Antriebsstrangvehicle dynamics control ; efficiency ; energieoptimal ; Elektrofahrzeug ; torque allocation ; Fahrdynamik ; over-actuated ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 15
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    Prädiktive Lichtfunktionen für volladaptive Scheinwerfersysteme (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: In this work, the realisation of an adaptive driving beam is examined that is based on the motion prediction of the ego vehicle and other traffic participants. Furthermore, light functions are developed and analysed regarding their effectiveness that project situation adaptive recommendations for action in front of the vehicle regarding a turn or lane change intention of the driver.
    Schlagwort(e): T1-995 ; Trajektorienprädiktion ; maneuver detection ; trajectory prediction ; predictive light functions ; Lichtbasierte Assistenzsysteme ; Prädiktive Lichtfunktionen ; Manöverdetektion ; light-based assistance systems ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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  • 16
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    The Global Race for Technological Superiority (2021)
    Ledizioni
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: This report published by ISPI and the Brookings Institution analyzes the challenges to international order posed by the ongoing race for technological superiority. From artificial intelligence and quantum computing to hypersonic weapons and new forms of cyber and electronic warfare, advances in technology have threatened to make the international security environment more unpredictable and volatile – yet the international community remains unprepared to assess and manage that risk. What is needed is a mature understanding of how technology has emerged as a key enabler of sovereignty in the XXI century, how the ongoing race for technological supremacy is disrupting the balance of power globally, and what the attendant strategic and security implications of those transformations will be. This report is an effort to that end.
    Schlagwort(e): T1-995 ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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  • 17
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    HLA-G-mediated Immune Tolerance: Past and New Outlooks (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Schlagwort(e): R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 18
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    Tourenplanung mit alternativen Lieferperioden und Teillieferungen (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: This book examines the Vehicle-Routing-Problem with split-deliveries and alternative delivery periods (SDVRPA). It is solved with a Branch-and-Price-Algorithm. When alternative delivery periods and split-deliveries are employed, freight forwarders get a wider scope for planning and can therefore plan more efficient routes. Even with few alternative delivery periods, which allow vehicles to be used more efficiently, substantial savings can be achieved.
    Schlagwort(e): T1-995 ; Column-Generation ; SDVRPAVehicle-Routing-Problem ; Alternative Periods ; SDVRPA ; Tourenplanung ; Teillieferungen ; Branch-Price-and-Cut ; Alternative Perioden ; Split-Deliveries ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 19
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    Recent Advances in Mechanics of Non-Newtonian Fluids (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: Non-Newtonian (non-linear) fluids are common in nature, for example, in mud and honey, but also in many chemical, biological, food, pharmaceutical, and personal care processing industries. This Special Issue of Fluids is dedicated to the recent advances in the mathematical and physical modeling of non-linear fluids with industrial applications, especially those concerned with CFD studies. These fluids include traditional non-Newtonian fluid models, electro- or magneto-rheological fluids, granular materials, slurries, drilling fluids, polymers, blood and other biofluids, mixtures of fluids and particles, etc.
    Schlagwort(e): TA1-2040 ; T1-995 ; Poiseuille–Couette flow ; membrane ; viscous fluid ; channel flow ; existence theorem ; yield stress ; hemoglobe capacitor ; creeping flows ; viscoplastic fluids ; projection method ; power-law fluid ; first- and second-order slip ; Mittag–Leffler ; lubrication ; viscoplastic fluid ; rupture ; convection ; Re numbers ; enhanced oil recovery (EOR) ; SPH-FEM ; Gamma densitometer ; oil recovery ; non-newtonian fluids ; marginal function ; particle interaction ; computational fluid dynamics ; non-isothermal flows ; suspensions ; Brinkman equation ; lubrication approximation (76A05 ; lid-driven cavity ; smoothed particle hydrodynamics (SPH) ; 76D08 ; Phan-Thien–Tanner (PTT) model ; bubble suspension ; porous media ; non-equilibrium thermodynamics ; porous medium ; suspension viscosity ; hemoglobin ; convection-diffusion ; slug translational velocity ; closure relationship ; non-linear fluids ; wormlike micellar solutions (WMS) ; high viscosity oil ; viscoelastic surfactants (VES) ; 76A20) ; meshless ; Bingham fluid ; Reynolds equation ; generalised simplified PTT ; dense suspension ; chemical EOR (cEOR) ; buoyancy force ; viscosity ratio ; aspect ratio ; rheology ; lubrication approximation ; fluid-solid interaction (FSI) ; optimal control ; natural convection ; biofluids ; shear-dependent viscosity ; thermodynamic capacitor ; shear-thinning ; stokesian dynamics ; weak solution ; biological capacitor ; cement ; variable viscosity ; Couette flow ; pressure boundary conditions ; inhomogeneous fluids ; boundary control ; similarity transformation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 20
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    Nanostructure Based Sensors for Gas Sensing: from Devices to Systems (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: The development of solid state gas sensors based on microtransducers and nanostructured sensing materials is the key point in the design of portable measurement systems able to reach sensing and identification performance comparable with analytical ones. In such a context several efforts must be spent of course in the development of the sensing material, but also in the choice of the transducer mechanism and its structure, in the electrical characterization of the performance and in the design of suitable measurement setups. This call for papers invites researchers worldwide to report about their novel results on the most recent advances and overview in design and measurements for applications in gas sensors, along with their relevant features and technological aspects. Original research papers are welcome (but not limited) on all aspects that focus on the most recent advances in: (i) basic principles and modeling of gas and VOCs sensors; (ii) new gas sensor principles and technologies; (iii) Characterization and measurements methodologies; (iv) transduction and sampling systems; (vi) package optimization; (vi) gas sensor based systems and applications.
    Schlagwort(e): TA1-2040 ; T1-995 ; indium oxide ; n/a ; environmental monitoring ; semiconductor ; gas sensor ; packed gas chromatographic column ; ultrathin carbon layer ; metal-oxide-semiconductor array sensor ; halitosis ; laser ablation ; capacitive micromachined ultrasonic transducers (CMUT) ; LTCC side via ; MEMS ; indirect packaging ; gas sensing ; efficiency ; bad breath ; electrospray ; array optimization ; low temperature co-fired ceramic (LTCC) ; electronic nose ; UV irradiation ; core/shell nanostructure ; combinatorial and high-throughput technique ; sensitive material ; hydrogen sulfide ; CO detection ; ZnO ; amperometric ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 21
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    Neues Konzept zur Bewegungsanalyse und -synthese für Humanoide Roboter basierend auf Vorbildern aus der Biologie (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: New methods to generate and analyze motions of humanoid robots are presented and applied to a demonstrator. Reflexes of humans and neural central pattern generators (CPGs) were used as archetype. With leaky Integrate-and-Fire neurons a generic reflex template was designed and put to work for several specialized reflexes. The designed CPGs were used to analyze robotik motion as well as for generation of locomotion patterns on a biped demonstrator.
    Schlagwort(e): T1-995 ; Reflexe ; Humanoider Roboter ; Zentrale MustergeneratorenHumanoid Robot ; CentralPatternGenerator ; Reflexes ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 22
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    Zum Phasengleichgewicht und Stofftransport in vernetzten Polymersystemen (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Die vorliegende Arbeit beschäftigt sich mit der Phasengleichgewichts- und Stofftransportcharakteristik vernetzter Polymere, wie sie in Controlled-Release-Anwendungen, der Brennstoffzellen- und Separationstechnologie oder der Sensor-Aktor-Technik zum Einsatz kommen. Dabei werden insbesondere auch Strategien zur quantitativen Bestimmung der relevanten Gleichgewichts- und Transportparameter vorgestellt, welche auf der Kopplung einer spektroskopischen Messmethode und Simulationsrechnungen basieren.
    Schlagwort(e): T1-995 ; Polymermembran ; Stofftransport ; Polyvinylalkohol ; Raman-Spektroskopie ; Phasengleichgewicht ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 23
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    Time-dependent spectrum analysis of high power gyrotrons (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: In this work, a novel measurement system for the analysis of the gyrotron RF output spectrum was developed. It enables unprecedented time dependent measurements within a large bandwidth, dynamic range and unambiguous RF indication in the entire D-Band (110-170 GHz). Special attention was given to the investigation of parasitic RF oscillations, and the analysis of the interplay of thermal cavity expansion and ionization-based space charge neutralization at the start of long RF pulses.
    Schlagwort(e): T1-995 ; spectrum analysis ; Mikrowellenmesstechnik ; millimeter waves ; Gyrotron ; Spektralanalyse ; Millimeterwellen ; microwave measurement techniques ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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  • 24
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    Neues Konzept für die bedarfsgerechte Energieversorgung des Künstlichen Akkommodationssystems (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: Das Wiederherstellen der Akkommodationsfähigkeit des Auges bei Presbyopie oder nach Kataraktoperationen stellt derzeit eine der größten Herausforderungen der Augenheilkunde dar. Das Künstliche Akkommodationssystem ermöglicht die dauerhafte Wiederherstellung der Akkommodationsfähigkeit. In der vorliegenden Arbeit wird ein neues Konzept für die bedarfsgerechte Energieversorgung des Künstlichen Akkommodationssystems erstellt.
    Schlagwort(e): T1-995 ; Akkommodationssystem bedarfsgerecht Energieversorgung ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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  • 25
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    Ein Verfahren zum automatischen Entwurf von Mensch-Maschine-Schnittstellen am Beispiel myoelektrischer Handprothesen (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Die Steuerung von künstlichen Gliedmaßen durch Muskel- bzw. Nervensignale oder von virtuellen Tastaturen durch Hirnsignale erfordert eine Schnittstelle, die die menschlichen Wünsche erfasst, interpretiert und dem angeschlossenen System verfügbar macht. Bestehende Systeme zeichnen sich durch eine einfache Bedienbarkeit aus, verfügen jedoch nur über eine eingeschränkte Funktionalität und müssen zudem manuell entworfen werden.In dieser Arbeit wird ein neues Verfahren zum automatischen Entwurf von MMIs vorgestellt und so die Funktionalität bestehender Systeme erweitert.
    Schlagwort(e): T1-995 ; Mensch-Maschine-Schnittstelle ; Diskriminanzfunktion ; Mensch-Maschine-Kommunikation ; Echtzeitverarbeitung ; Entwurfsautomation ; Steuerung ; Lernende Steuerung ; Klassifikation ; Muskelkontraktion ; Systementwurf ; Gehirn-Computer-Schnittstelle ; Echtheit / Merkmal ; Diskriminanzanalyse ; Elektromyographie ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 26
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    Mechanical Loading and Bone (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2022-01-31
    Beschreibung: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Schlagwort(e): RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
    Sprache: Englisch
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  • 27
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    Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Schlagwort(e): R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 28
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    Transmucosal Absorption Enhancers in the Drug Delivery Field (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Schlagwort(e): R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
    Format: application/octet-stream
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  • 29
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    Magnetic Resonance Imaging on Patients with Implanted Cardiac Pacemakers (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: The aim of this work was to identify the patterns that can induce heating around implanted cardiac pacemakers during MRI and to develop strategies to counteract them. Two approaches were taken: computer simulations of the occurring electromagnetic field distributions and in-vitro experiments using phantoms in real MRI devices, both for conventional bore-hole and new open MRI systems. Using the open MRI, the observed heating could be reduced significantly.
    Schlagwort(e): T1-995 ; pacemaker ; MRI ; numerical field calculation ; biomedical engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 30
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    Solution Models based on Symmetric and Asymmetric Information (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: This Special Issue covers symmetry and asymmetry phenomena occurring in real-life problems. We invited authors to submit their theoretical or experimental research presenting engineering and economic problem solution models dealing with the symmetry or asymmetry of different types of information. The issue gained interest in the research community and received many submissions. After rigorous scientific evaluation by editors and reviewers, nine papers were accepted and published. The authors proposed different MADM and MODM solution models as integrated tools to find a balance between the components of sustainable global development, to find a symmetry axis concerning goals, risks, and constraints to cope with the complicated problems. Most approaches suggested decision models under uncertainty, combining the usual decision-making methods with interval-valued fuzzy or rough sets theory, also Z numbers. The application fields of the proposed models involved both problems of technological sciences and social sciences. The papers cover three essential areas: engineering, economy, and management. We hope that a summary of the Special Issue as provided here will encourage a detailed analysis of the papers included in the Printed Edition.
    Schlagwort(e): TA1-2040 ; T1-995 ; rough sets ; interval type-2 fuzzy set (IT2FS) ; resources distribution ; the criteria of the weights ; public management ; Step-wise Weight Assessment Ratio Analysis (SWARA) ; multi-criteria decision-making (MCDM) ; symmetry of the method ; quadcopter ; transaction cost ; full fuzzy environment ; dual generalized geometric Bonferroni mean (DGGBM) operator ; data logger ; information theory ; control system ; salvage value ; nonlinear dynamics ; pattern formation ; oscillations ; stability ; Pythagorean fuzzy set ; FAHP ; fuzzy sets ; group decision-making ; generalized Bonferroni mean (GBM) operator ; probabilistic systems analysis ; economic decisions ; 2-tuple linguistic neutrosophic numbers set (2TLNNSs) ; evaluating the quality of distant courses ; subjective weights ; Z-numbers ; green supplier selection ; dual generalized Bonferroni mean (DGBM) operator ; normal cloud ; thrust ; sensor ; neutrosophic numbers ; MCDM ; Bayes’ theorem ; optimal dividend ; logistics ; measurement ; hybrid MCDM ; combining the weights ; data envelopment analysis ; criteria weights ; multiple attribute decision making (MADM) ; IDOCRIW ; excess-of-loss reinsurance ; fuzzy efficiency ; multiple-criteria decision-making (MCDM) ; MCGDM ; transport ; backward cloud transformation ; engineering problems ; rough ARAS ; capital injection ; performance ; Bonferroni mean (BM) operator ; green supply chain management ; population sizes ; hybrid problem solution models ; criteria weight assessment ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 31
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    Werkstoffanalytische Betrachtung der Eigenschaften von mittels neuartiger RTM-Fertigungsprozesse hergestellten glasfaserverstärkten Polymerverbunden (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: In this work fiber reinforced polymers were characterized. The composites were manufactured with optimized resin transfer molding (RTM) production strategies to make the standard RTM process more efficient. To determine where the potential of the new production techniques is the quasi static mechanical properties were measured and also calculated with an analytical modulation. On this database the different processes were compared to each other.
    Schlagwort(e): T1-995 ; Werkstoffprüfung ; RTM-Fertigungsverfahren ; process comparison ; Polymer ; RTM ; Verbundwerkstoff ; materials characterization ; RTM manufacturing process ; Glasfaser ; aserverbundwerkstoffe ; Prozessvergleich ; fiber reinforced polymers ; Materialcharakterisierung ; Analytische Modellierung ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 32
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    Realization Limits of Impulse-Radio UWB Indoor Localization Systems (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: In this work, the realization limits of an impulse-based Ultra-Wideband (UWB) localization system for indoor applications have been thoroughly investigated and verified by measurements. The analysis spans from the position calculation algorithms, through hardware realization and modeling, up to the localization experiments conducted in realistic scenarios. The main focus was put on identification and characterization of limiting factors as well as developing methods to overcome them.
    Schlagwort(e): T1-995 ; localization ; UWB ; transceiver ; positioning ; ultra-wideband ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 33
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    Middleware Solutions for Wireless Internet of Things (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: The proliferation of powerful but cheap devices, together with the availability of a plethora of wireless technologies, has pushed for the spread of the Wireless Internet of Things (WIoT), which is typically much more heterogeneous, dynamic, and general-purpose if compared with the traditional IoT. The WIoT is characterized by the dynamic interaction of traditional infrastructure-side devices, e.g., sensors and actuators, provided by municipalities in Smart City infrastructures, and other portable and more opportunistic ones, such as mobile smartphones, opportunistically integrated to dynamically extend and enhance the WIoT environment. A key enabler of this vision is the advancement of software and middleware technologies in various mobile-related sectors, ranging from the effective synergic management of wireless communications to mobility/adaptivity support in operating systems and differentiated integration and management of devices with heterogeneous capabilities in middleware, from horizontal support to crowdsourcing in different application domains to dynamic offloading to cloud resources, only to mention a few. The book presents state-of-the-art contributions in the articulated WIoT area by providing novel insights about the development and adoption of middleware solutions to enable the WIoT vision in a wide spectrum of heterogeneous scenarios, ranging from industrial environments to educational devices. The presented solutions provide readers with differentiated point of views, by demonstrating how the WIoT vision can be applied to several aspects of our daily life in a pervasive manner.
    Schlagwort(e): TA1-2040 ; T1-995 ; container ; fog computing ; virtual reality ; privacy and security ; software defined infrastructure ; intelligent medical service ; very long instruction word (VLIW) ; semantics ; privacy leakage detection ; context information ; post-copy ; ontology ; body area network ; DSP ; Internet-of-Things ; Mobile Device Management ; interoperability ; Android ; water consumption ; Processing-in-Memory ; performance analysis ; semantic ; mobility ; data management ; CRIU ; training simulator ; Industry 4.0 ; sensor networks ; experimental evaluation ; programming paradigm ; pre-copy ; microservice-oriented platform ; CubeSats ; middleware ; registry ; smart metering ; big data analytics ; nanosatellites ; medium access control ; Internet of Things ; heterogeneity ; web-of-things ; one-to-one computing educational program ; Web-of-Things ; internet of things ; instruction set extension ; microservices architecture ; migration ; behaviour ; wireless access networks ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 34
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    Untersuchung der Schwingungseigenschaften von teleskopierbaren Maschinenelementen mit Spiel am Beispiel eines Gabelstapler-Hubgerüstes (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: Teleskopierbare, spielbehaftete Hubgerüste von Gabelstaplern werden während eines Arbeitszyklus oftmals zu Schwingungen angeregt. Die charakteristischen Schwingungseigenschaften, bedingt durch das usammenwirken von Spiel, auskragender Last und Schwerkraft, werden experimentell untersucht und durch ein 5-Massen-Modell sehr gut abgebildet.Sowohl mit aktiven als auch mit passiven Maßnahmen lassen sich die Schwingungen schnell und deutlich reduzieren.
    Schlagwort(e): T1-995 ; Maschinenelement ; Spiel ; Schwingungsverhalten ; Gabelstapler ; Flurförderer ; Hubgerüst ; Schwingungsdämpfer ; Schwingungstilger ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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  • 35
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    Beitrag zur modellbasierten Regelung von Verbrennungsprozessen (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Verbrennungsprozesse sind meist mit der Emission von Schadstoffen verbunden, weshalb sie möglichst schadstoffarm und energieeffizient geführt werden müssen.Bei den bislang dominierenden primären Brennstoffen sind aufgrund der gleichbleibenden Brennstoffeigenschaften langfristig optimierte Technologien und feste Regelungen einsetzbar. Zunehmend werden jedoch sekundäre Brennstoffe wie Prozessabgase oder Biomasse genutzt. Sie haben stark veränderliche chemisch-physikalische Eigenschaften und bewirken so einen veränderlichen Verbrennungsablauf der schwierig beherrschbar ist. Eine optimale Verbrennung lässt sich dann nur durch eine an den Verbrennungszustand und die Brennstoffe adaptierte modellbasierte Prozessregelung erreichen, die noch nicht Stand der Technik ist.Die Arbeit widmet sich im ersten Schwerpunkt dem modellbasierten Reglungsentwurf. Die theoretische Modellierung und der modellbasierte Entwurf adaptiver Regelungen für die Temperatur und die Sauerstoffkonzentration im Abgas wird am Beispiel einer halbtechnischen Brennkammer für veränderliche Brenngase analysiert. Berücksichtigt wird dabei das für Verbrennungen typische vorhaltbehaftete Regelstreckenverhalten.Der zweite Schwerpunkt bildet die online Messung und die rechnerba-sierte Auswertung von Zustandsgrößen am Beispiel der infrarotbasierten Temperaturmessung bei einem Feststoffbrennbett. Es werden neue Auswerteverfahren entwickelt, die sich u.a. auch bei der Regelung industrieller Verbrennungen bewährt haben.
    Schlagwort(e): T1-995 ; Modellierung ; Verbrennungsanalyse ; Regelungstechnik ; Technikumsanlage ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 36
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    Direct hydroxylation of benzene to phenol in a microstructured Pd-based membrane reactor (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: The gas phase direct hydroxylation of benzene into phenol with hydrogen and oxygen, as initially described by Niwa in 2002, was realized in a newly developed double-membrane reactor. In the concept described by Niwa, a dense Pd membrane is used for the (safe) dosage of dissociated hydrogen species into the tubular reaction zone, where it reacts with gas phase oxygen to form surface species capable of directly converting benzene into phenol in a single-step process.
    Schlagwort(e): T1-995 ; Pd-Membran ; Katalyse ; Phenol ; Benzol ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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  • 37
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    Magnetization of High Temperature Superconducting Trapped-Field Magnets (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: High temperature superconducting (HTS) bulks and stacks of coated conductors can be magnetized to become trapped-field magnets that provide much stronger magnetic fields than those reachable with conventional permanent magnets. This work investigates the flux dynamics during the magnetization of HTS trapped-field magnets and proposes possible strategies to improve the trapped field produced by the pulsed field magnetization method that is promising for practical applications.
    Schlagwort(e): T1-995 ; trapped-field magnet ; Hochtemperatur-Supraleiter ; pulsed field magnetization ; High temperature superconductor ; Supraleiter mit eingeschlossenem Magnetfeld ; gepulste Feldmagnetisierung ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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  • 38
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    Radiation Tolerant Electronics (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: Research on radiation-tolerant electronics has increased rapidly over the past few years, resulting in many interesting approaches to modeling radiation effects and designing radiation-hardened integrated circuits and embedded systems. This research is strongly driven by the growing need for radiation-hardened electronics for space applications, high-energy physics experiments such as those on the Large Hadron Collider at CERN, and many terrestrial nuclear applications including nuclear energy and nuclear safety. With the progressive scaling of integrated circuit technologies and the growing complexity of electronic systems, their susceptibility to ionizing radiation has raised many exciting challenges, which are expected to drive research in the coming decade. In this book we highlight recent breakthroughs in the study of radiation effects in advanced semiconductor devices, as well as in high-performance analog, mixed signal, RF, and digital integrated circuits. We also focus on advances in embedded radiation hardening in both FPGA and microcontroller systems and apply radiation-hardened embedded systems for cryptography and image processing, targeting space applications.
    Schlagwort(e): TA1-2040 ; TK1-9971 ; T1-995 ; single event effects ; n/a ; radiation-hardening-by-design (RHBD) ; frequency divider by two ; single event upset ; Image processing ; CMOS analog integrated circuits ; FPGA ; total ionizing dose (TID) ; Impulse Sensitive Function ; soft error ; hardening by design ; radiation hardening by design ; X-rays ; Single-Event Upsets (SEUs) ; line buffer ; heavy ions ; VHDL ; FPGA-based digital controller ; radiation hardening by design (RHBD) ; radiation hardening ; SRAM-based FPGA ; proton irradiation ; ring oscillator ; sensor readout IC ; fault tolerance ; space application ; physical unclonable function ; voltage controlled oscillator (VCO) ; Ring Oscillators ; analog single-event transient (ASET) ; single event opset (SEU) ; SEB ; single event upsets ; bipolar transistor ; total ionizing dose ; protons ; triple modular redundancy (TMR) ; gain degradation ; space electronics ; saturation effect ; configuration memory ; Co-60 gamma radiation ; total ionization dose (TID) ; frequency synthesizers ; CMOS ; PLL ; TDC ; single-event upsets (SEUs) ; bandgap voltage reference (BGR) ; 4MR ; single-shot ; error rates ; Radiation Hardening by Design ; soft errors ; heavy-ions ; single-event effects (SEE) ; single event transient (SET) ; SEE testing ; proton irradiation effects ; RFIC ; single event upset (SEU) ; FMR ; ionization ; radiation tolerant ; triplex–duplex ; neutron irradiation effects ; digital integrated circuits ; single event gate rupture (SEGR) ; power MOSFETs ; ring-oscillator ; selective hardening ; voltage reference ; nuclear fusion ; TMR ; gamma-rays ; gamma ray ; instrumentation amplifier ; radiation effects ; reference circuits ; radiation-hardened ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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    Smart Sensors for Structural Health Monitoring (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: Smart sensors are technologies designed to facilitate the monitoring operations. For instance, power consumption can be minimized through on-board processing and smart interrogation algorithms, and state detection enhanced through collaboration between sensor nodes. Applied to structural health monitoring, smart sensors are key enablers of sparse and dense sensor networks capable of monitoring full-scale structures and components. They are also critical in empowering operators with decision making capabilities. The objective of this Special Issue is to generate discussions on the latest advances in research on smart sensing technologies for structural health monitoring applications, with a focus on decision-enabling systems. This Special Issue covers a wide range of related topics such as innovative sensors and sensing technologies for crack, displacement, and sudden event monitoring, sensor optimization, and novel sensor data processing algorithms for damage and defect detection, operational modal analysis, and system identification of a wide variety of structures (bridges, transmission line towers, high-speed trains, masonry light houses, etc.).
    Schlagwort(e): TA1-2040 ; T1-995 ; NSGA-II ; wind force ; wavelet packet decomposition ; structural health monitoring ; amplitude spectrum ; environmental noise ; patch antenna ; damage identification ; event-triggered sensing ; Particle Swarm Optimization (PSO) algorithm ; high-speed train ; low-velocity impacts ; concrete structures ; sensors distribution optimization ; acceleration ; digital sampling moiré ; crack ; displacement sensor ; length effect ; FBG sensor array ; SHM ; space window ; Bayesian blind source separation ; feature selection ; stress detection ; wheel minor defect ; strain ; uniaxial stress measurement ; turbine ; impact identification ; helical antenna ; energy analysis of wavelet band ; strain wave ; time window ; structural steel members ; steel frame ; acoustoelastic effect ; demand-based nodes ; online wayside detection ; sensor ; bridge ; sensitivity ; acoustic emission ; bending stiffness ; wireless smart sensors ; distributed dense sensor network ; mapping construction ; data fusion ; fuzzy classification ; shear-wave birefringence ; normal mode ; piezoelectric wafer active sensors ; resonant frequency ; electromagnetic oscillation ; settlement ; sensor optimization ; modal frequencies ; perturbation theory ; feature extraction ; Virtual Distortion Method (VDM) ; reflective optical sensor ; fibre bundle ; smartphones ; crack identification ; active sensing ; test vehicle ; calibration ; stretching method ; model updating ; rotary ultrasonic array ; 2D crack growth ; data processing ; damage detection ; impactor stiffness ; tip clearance ; transmission tower ; phase spectrum ; concrete crack ; structural impact monitoring ; shaking table tests ; optical crack growth sensor ; steel strand ; passive sensing ; sudden event monitoring ; aero engine ; principal component analysis ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 40
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    Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Schlagwort(e): R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    Advanced Mobile Robotics: Volume 3 (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: Mobile robotics is a challenging field with great potential. It covers disciplines including electrical engineering, mechanical engineering, computer science, cognitive science, and social science. It is essential to the design of automated robots, in combination with artificial intelligence, vision, and sensor technologies. Mobile robots are widely used for surveillance, guidance, transportation and entertainment tasks, as well as medical applications. This Special Issue intends to concentrate on recent developments concerning mobile robots and the research surrounding them to enhance studies on the fundamental problems observed in the robots. Various multidisciplinary approaches and integrative contributions including navigation, learning and adaptation, networked system, biologically inspired robots and cognitive methods are welcome contributions to this Special Issue, both from a research and an application perspective.
    Schlagwort(e): TA1-2040 ; T1-995 ; similarity measure ; swarm-robotics ; drag-based system ; PID algorithm ; human–robot interaction ; behaviour dynamics ; state constraints ; fair optimisation ; micro mobile robot ; robot ; actuators ; high-gain observer ; turning model LIP ; space robot ; manipulation action sequences ; subgoal graphs ; remotely operated vehicle ; constrained motion ; joint limit avoidance ; curvilinear obstacle ; rehabilitation system ; stability criterion ; system design ; quad-tilt rotor ; iterative learning ; spiral curve ; cable detection ; SEA ; douglas–peuker polygonal approximation ; predictable trajectory planning ; ATEX ; obstacle avoidance system ; kinematic singularity ; collision avoidance ; biologically-inspired ; jumping robot ; differential wheeled robot ; design and modeling ; control efficacy ; robotics ; extremum-seeking ; object-oriented ; non-holonomic mobile robot ; magneto-rheological fluids ; rendezvous consensus ; altitude controller ; master-slave ; switching control ; deep reinforcement learning ; mechanism ; expansion logic strategy ; negative buoyancy ; action generation ; radial basis function neural networks ; unmanned aerial vehicles ; extend procedure ; glass façade cleaning robot ; convolutional neural network ; climbing robot ; micro air vehicle ; car-like kinematics ; variable speed ; machine learning ; dynamical model ; transportation ; geodesic ; unmanned surface vessel ; medical devices ; stopper ; extended state observer (ESO) ; high efficiency ; object mapping ; multi-objective optimization ; hybrid robot ; robot learning ; auto-tuning ; cable disturbance modeling ; manipulation planning ; pesticide application ; high-speed target ; sparse pose adjustment (SPA) ; service robot ; lumped parameter method ; Geometric Algebra ; dynamic coupling analysis ; Thau observer ; tri-tilt-rotor ; industrial robotic manipulator ; hardware-in-the-loop simulation ; robotic drilling ; muscle activities ; small size ; chameleon ; continuous hopping ; wall climbing robot ; hover mode ; 3D-SLAM ; curvature constraints ; PSO ; drilling end-effector ; Rodrigues parameters ; gait adaptation ; static environments ; position/force cooperative control ; snake-like robot ; shape-fitting ; powered exoskeleton ; input saturation ; kinematic identification ; methane ; human–machine interactive navigation ; q-learning ; path following ; hopping robot ; mobile manipulation ; high step-up ratio ; actuatorless ; monocular vision ; stability analysis ; compact driving unit ; snake robot ; non-holonomic robot ; curvature constraint ; phase-shifting ; dialytic elimination ; gesture recognition ; snake robots ; series elastic actuator ; flapping ; servo valve ; motion camouflage control ; biomimetic robot ; minimally invasive surgery robot ; centralized architecture ; trajectory planning ; computing time ; adaptive control law ; kinematics ; facial and gender recognition ; single actuator ; victim-detection ; shape memory alloys ; undiscovered sensor values ; discomfort ; Differential Evolution ; numerical evaluation ; quadruped robot ; coverage path planning ; localization ; MPC ; n/a ; fault diagnosis ; neural networks ; disturbance-rejection control ; sample gathering problem ; cart ; bio-inspired robot ; opposite angle-based exact cell decomposition ; optimization ; safety ; goal exchange ; hierarchical planning ; ocean current ; robot motion ; nonlinear differentiator ; mapping ; finite-time currents observer ; Newton iteration ; inverse kinematics ; deposition uniformity ; spatial pyramid pooling ; hierarchical path planning ; end effector ; head-raising ; fault recovery ; LOS ; path tracking ; non-inertial reference frame ; step climbing ; obstacle avoidance ; sliding mode control ; symmetrical adaptive variable impedance ; lane change ; quadcopter UAV ; singularity analysis ; biped mechanism ; fault-tolerant control ; dynamic neural networks ; mobile robots ; data association ; UAV ; enemy avoidance ; reinforcement learning ; grip optimization ; safety recovery mechanism ; exoskeleton ; dynamic environment ; uncertain environments ; hybrid bionic robot ; potential field ; robot navigation ; cleaning robot ; unmanned aerial vehicle ; non-singular fast-terminal sliding-mode control ; contact planning ; Lyapunov-like function ; piezoelectric actuator ; transition mode ; non-prehensile manipulation ; multiple mobile robots ; Tetris-inspired ; real-time action recognition ; integral line-of-sight ; topological map ; alpine ski ; target tracking ; closed-loop detection ; working efficiency ; mathematical modeling ; curve fitting ; force control ; biped robots ; NSGA-II ; mobile robot ; load carriage ; prescription map translation ; artificial fish swarm algorithm ; Q-networks ; self-reconfigurable robot ; G3-continuity ; autonomous vehicle ; loop closure detection ; excellent driver model ; robots ; graph representation ; regional growth ; target assignment ; evolutionary operators ; intelligent mobile robot ; motion sensor ; exploration ; droplets penetrability ; dynamic uncertainty ; simultaneous localization and mapping (SLAM) ; area decomposition ; multi-criteria decision making ; 4WS4WD vehicle ; biped climbing robots ; skiing robot ; ROS ; decision making ; smart materials ; centrifugal force ; missile control system ; formation of robots ; electro-rheological fluids ; pneumatics ; variable spray ; inertial measurement unit (IMU) ; Robot Operating System ; trajectory interpolation ; formation control ; immersion and invariance ; dragonfly ; parallel navigation ; harmonic potential field ; pallet transportation ; mobile robot navigation ; negative-buoyancy ; grip planning ; manipulator ; position control ; external disturbance ; legged robot ; passive skiing turn ; autonomous underwater vehicle (AUV) ; gait cycle ; path planning ; sliding mode observer ; dynamic gait ; self-learning ; polyomino tiling theory ; coalmine ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 42
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    Modeling of electrophysiology and tension development in the human heart (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Comprehension of the beating of the human heart is important for cardiac research and will improve many clinical applications. Simulations based on models describing cardiac electro-mechanics can acquire insights into this behavior. This work focuses on the mathematical reconstruction of electrophysiology, excitation conduction, and tension development in the human heart on the cellular and the tissue level. The tissue models represent accurate anatomical shapes of the atria and the ventricles and incorporate electrophysiological heterogeneity and anisotropic conduction. The simulations comprehend the physiological behavior of the ventricles and of the atrium including the sinoatrial node as well as pathological cases like ventricular and atrial fibrillation and genetic defects in ionic channels.
    Schlagwort(e): T1-995 ; Heterogenität ; Gewebe ; Kardiologie ; Computersimulation ; Ionenkanal ; Aktionspotenzial ; Erregung ; Elektrophysiologie ; Muskelfaser ; Kraft ; Tachykardie ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 43
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    Flow control : theoretical concept of absolute instability (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: At the 37th Prandtl memorial lecture on Regions of Viccous Flow, H.Oertel 1994 developed for the first time the stability theory of local perturbations in boundary layers and wake flows, as well as their practical application in the flow control of vehicle flows and the boundary layer of civil aircraft wings.This work presents how the stability theory concept of absolute instability has advanced and proven in practice in the last 15 years in terms of the efficient flow control.
    Schlagwort(e): T1-995 ; Flow Control ; Fluid Mechanics ; Stability Theory ; Wake Flow ; Bundary Layer Transition ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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  • 44
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    How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Schlagwort(e): R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    Modeling and Experimental Characterization of Nanocomposite Materials (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: This Special Issue gathers research from different branches of science and engineering disciplines working on experiments and modelling of nanocomposites into one volume. The Guest Editor welcomes papers dedicated to experimental, computational, and theoretical aspects dealing with many important state-of-the-art technologies and methodologies regarding the synthesis, fabrication, characterization, properties, design, and applications, and both finite element analysis and molecular dynamic simulations, of nanocomposite materials and structures. Full papers covering novel topics, extending the frontiers of the science and technology of nanoreinforced composites are encouraged. Reviews covering topics of major interest will be also considered.
    Schlagwort(e): TA1-2040 ; T1-995 ; ab initio ; critical yield strength ; carbon nanotube ; impact buckling ; elasticity ; molecular dynamics simulation ; magnetism ; coarse-grained model ; 3D fiber-metal laminates ; mechanical property ; interface ; nanocomposites ; interface force fields ; YN ; graphene/Fe composite ; cohesive element ; stability ; ScN ; delamination propagation ; interfaces ; graphene nanoplatelets ; nanoindentation ; pressure ; molecular dynamics ; piezoelectric property ; temperature effect ; Fe-Al ; hardness ; equivalent fiber ; disorder ; Fe3Al ; elastic modulus ; delamination buckling ; CNT agglomeration ; CNTs/epoxy nanocomposites ; boron nitride honeycomb ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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    Measuring the Impact of Lean Techniques on Performance Indicators in Logistics Operations (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Several in-depth studies have verified the positive impact of lean techniques on performance indicators in production environments. Studies performed on warehouse environments have partially confirmed this. This thesis helped to close the gap between the disparities in the level of evidence mentioned above. A study was conducted that included 16 warehouses in an observation group and 56 warehouses in a control group. These significant results help close the gap in the evidence.
    Schlagwort(e): T1-995 ; Lean Management ; Lean Production ; schlanke Produktionssysteme ; Lager ; LogistikLean Management ; KPI ; Logistikzentren ; Lean Warehousing ; Logistics ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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  • 47
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    Unternehmensspezifisches Klassifikationssystem zur effizienten Datenverwaltung (mit Anwendungsszenarien aus der Praxis). Abschlußbericht des Verbundprojektes ""Klassifikationssysteme automatisiert erstellen"" (KLASTER) + 1 CD (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Innerhalb des zweijährigen Verbundprojektes KLASTER (Klassifikationssysteme automatisiert erstellen) wurde aufbauend auf den Ergebnissen des Vorgängerprojektes PAK (Produkte automatisch klassifizieren) ein Konzept erarbeitet und validiert, das eine Automatisierung des Klassifizierungsprozesses erlaubt. Während innerhalb von PAK die automatische Einordnung von Objekten in eine existierende Klassenstruktur behandelt wurde, beschäftigt sich KLASTER mit der automatischen Erstellung eines unternehmensspezifischen Klassensystems.Der vorliegende Abschlussbericht beschreibt neben dem Konzept ausführlich Anwendungsbeispiele bei den beteiligten Projektpartnern.
    Schlagwort(e): T1-995 ; Klassifikation ; Datenverwaltung ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 48
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    Spurführungsregelung eines aktiv gelenkten Radpaars für Straßenbahnen (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: This work presents investigates the feasibility of the ""directly steered wheels (DSW)"" under operating condition of tramcars. After analyzing the wheel/rail geometric contact between track and DSW, a mathematical model has been developed to describe the lateral dynamics. Based on this model, a robust guidance controller is designed according to the µ-synthesis. The results of simulations show that the DSW with the designed controller can improve the running performance of tramcars significantly.
    Schlagwort(e): T1-995 ; aktive Spurführung ; active guidance ; directly steered wheels ; Straßenbahn&#956 ; -Synthesis ; µ-synthesis ; wheel/rail geometric contact ; Rad-Schiene-Kontaktkinematik ; aktiv gelenktes Radpaar ; tramcar ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 49
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    AlGaN/GaN-HEMT power amplifiers with optimized power-added efficiency for X-band applications (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: This work has arisen out of the strong demand for a superior power-added efficiency (PAE) of AlGaN/GaN high electron mobility transistor (HEMT) high-power amplifiers (HPAs) that are part of any advanced wireless multifunctional RF-system with limited prime energy. Different concepts and approaches on device and design level for PAE improvements are analyzed, e.g. structural and layout changes of the GaN transistor and advanced circuit design techniques for PAE improvements of GaN HEMT HPAs.
    Schlagwort(e): T1-995 ; MMIC design ; power amplifier ; AlGaN/GaN HEMT ; X-band ; power-added efficiency ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 50
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    Recent advances in γδ T cell biology: New ligands, new functions, and new translational perspectives (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Schlagwort(e): R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    Ansätze zur akustischen Optimierung von Reifen und Fahrbahnen für Elektrofahrzeuge unter Antriebsmoment (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: This work systematically describes the mechanisms of tyre/road noise atdriving and braking torque based on measurements with different tyres. The studies on the influence of circumferential force on tyre/road noise can be divided into two different tire tread designs. One sub-chapter reports about a selective influence of force induced tyre/road noise using inclined groove edges. The influence of the circumferential stiffness of the tread blocks on the tyre/road noise is discussed afterwards.
    Schlagwort(e): T1-995 ; Elektrofahrzeug ; electric vehicle ; Reifen-Fahrbahn-Geräusch ; Antriebsmomenttyre-road-noise ; driving torque ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 52
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    Produktgestaltung an kolloidalen Agglomeraten und Gelen : Gelierung und Fragmentierung anorganisch gefällten Siliciumdioxids (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Amorphes Siliciumdioxid findet als Füllstoff verbreitet Anwendung. Es wird u.a. durch die Vermischung einer Silikatlösung mit einer Säure hergestellt. Dabei entsteht intermediär ein Gel. Mit dieser Arbeit wird ein Beitrag zur Steuerung der Eigenschaften des Produktpulvers geleistet. Es wird eine Formel vorgestellt, mit der die Gelierzeit aus den Konzentrationen der Einsatzstoffe abgeschätzt werden kann. Für die Fragmentierung des Gels werden Parallelen zum Aufbruch hochviskoser Tropfen gezeigt.
    Schlagwort(e): T1-995 ; Kolloide ; Gelierung ; Verfahrenstechnik ; Agglomeration ; Partikeltechnologie ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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    Advances in Food and By-Products Processing Towards a Sustainable Bioeconomy (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: The bioeconomy initially focused on resource substitution, including the production of biomass from various resources; its conversion, fractionation, and processing by means of biotechnology; and chemistry and process engineering towards the production and marketing of food, feed, fuel, and fibre. Nevertheless, although resource substitution is still considered important, the emphasis has been recently shifted to the biotechnological innovation perspective of the bioeconomy, in terms that ensure environmental sustainability. It is estimated that around one-third of the food produced for human consumption is wasted throughout the world, posing not only a sustainability problem related to food security but also a significant environmental problem. Food waste streams, mainly derived from fruits and vegetables, cereals, oilseeds, meat, dairy, and fish processing, have unavoidably attracted the interest of the scientific community as an abundant reservoir of complex carbohydrates, proteins, lipids, and functional compounds, which can be utilized as raw materials for added-value product formulations. This Special Issue focuses on innovative and emerging food and by-products processing methods for the sustainable transition to a bioeconomy era.
    Schlagwort(e): TP248.13-248.65 ; T1-995 ; ash content ; sorghum milling waste ; lipids ; compost ; oleic acid ; microbial oil ; bioprocess development ; glucoamylase ; fatty acid methyl esters ; oleaginous yeast ; integrated biorefineries ; biorefineries ; hydrophobic substrates ; food processing ; hydrophilicity ; biodiesel ; films ; biodegradability ; clarified butter sediment waste ; submerged fungal fermentation ; blood plasma protein powder ; Morchella ; hydrogels ; heat-induced gelation ; sustainability ; bacterial cellulose ; bioprocesses ; circular economy ; olive waste ; prebiotics ; Rhodosporidium toruloides ; carotenoids ; waste valorization ; glucosamine ; food-processing ; size exclusion chromatography (SEC) ; bioeconomy ; food waste valorization ; whey proteins ; arabinoxylan ; Ostwald ripening ; emulsion ; emulsifier ; food biotechnology ; drying method ; polysaccharides ; food packaging ; texture ; lactose esters ; morel mushrooms ; circular-economy ; solid state fermentation ; bioactive compounds ; edible films ; hydrolysis ; Aspergillus awamori ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
    Sprache: Englisch
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  • 54
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    Numerische Untersuchung des Verformungs- und Bruchverhaltens von einkristallinem Wolfram auf mikroskopischer Ebene (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: The aim of the present work is to describe the deformation and fracture behavior of single crystal tungsten at the microscopic scale by using the ?nite element method. Therefore, the studies focus mainly on the in?uence of crystal orientation as well as the investigation of crack initiation and crack propagation. With a defined crack propagation model, the simulations of microbending allows for evaluating the details of the fracture process more accurately and supported the experimental studies.
    Schlagwort(e): T1-995 ; Microcracking ; Finite elements ; Crystal plasticity ; Wolframeinkristall ; KristallplastizitätSingle Crystal Tungsten ; Bruchzähigkeit ; Finite Elemente ; Mikrorißbildung ; Fracture toughness ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 55
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    High Voltage Engineering and Applications (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: This book is a collection of recent publications from researchers all over the globe in the broad area of high-voltage engineering. The presented research papers cover both experimental and simulation studies, with a focus on topics related to insulation monitoring using state-of-the-art sensors and advanced machine learning algorithms. Special attention was given in the Special Issue to partial discharge monitoring as one of the most important techniques in insulation condition assessment. Moreover, this Special Issue contains several articles which focus on different modeling techniques that help researchers to better evaluate the condition of insulation systems. Different power system assets are addressed in this book, including transformers, outdoor insulators, underground cables, and gas-insulated substations.
    Schlagwort(e): TA1-2040 ; T1-995 ; artificial neural network ; simulation ; high-frequency ; artificial flashover tests ; wide bandgap power modules ; tracking ; electrical field strength ; fast-rise square wave voltages ; FDTD simulation ; cable joint ; corona discharge ; feature selection ; post insulator ; earthing systems ; wind speed ; surface discharge ; oil/paper insulation ; oil-paper insulation ; high-magnitude currents and impulse polarity ; UFVM ; Tettex 9520 ; electrical tree ; flashover characteristics ; composite insulator ; partial discharge ; numerical modeling ; saline mechanism ; thermal parameters ; space charge density ; seasonal ; ion flow field ; denoising ; DDX 9121b ; temperature ; transformer asset management ; cavity discharge ; space/interface charge ; insulation health index ; heat transfer model ; leakage current ; machine learning ; partial discharges (PD) ; RF signal ; flashover ; high impulse conditions ; grounding electrodes ; generalized finite difference time domain ; curve fitting ; grounding ; plasma discharge ; outdoor insulators ; flashover dynamic model ; wavelet transform ; degradation ; thermal properties ; bipolar charge transport model ; UHF sensor ; cable ; random walk theory ; tracking test setup ; GIL ; pressure ; modelling ; non-uniform pollution between windward and leeward sides ; calibrator ; secondary arc ; polymeric insulation ; optical-UHF integrated detection ; shoreline ; dry band arcing ; photoelectric fusion pattern ; DDX 8003 ; XLPE ; silicone gel ; partial discharge modeling ; electric field analysis ; NSCT ; electrode’s geometry ; gas ; Comsol Multiphysics ; fast-impulses ; laying modes ; ageing ; cable ampacity ; residual resistance formulation ; finite element analysis ; thermal effect ; hydrophobicity ; soil resistivity ; charge simulation method ; short-circuit discharge ; dry band formation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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    Bewertung der Energieeffizienz von Antriebssystemen mobiler Arbeitsmaschinen am Beispiel Bagger (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: In this book a methodology for the evaluation of energy efficiency of mobile working machines by simulation is presented. It allows an efficiency analysis and systematic optimization of a single power train as well as a comparison of different power train concepts. The methodology is applied to a wheeled excavator. To ensure a realistic power demand in the simulation, a rule-based operator model is developed.
    Schlagwort(e): T1-995 ; simulation ; Energieeffizienz ; Bagger ; Mobile Arbeitsmaschinen ; Bewertungsmethodik ; Antriebssysteme ; Fahrermodellmobile machines ; excavator ; Simulation ; operator model ; energy efficiency ; evaluation methodology ; power trains ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 57
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    Durchgängige Timing-Bewertung von Vernetzungsarchitekturen und Gateway-Systemen im Kraftfahrzeug (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Die steigende Anzahl von Elektrik-/Elektronik-Systemen im Automobil und damit verbunden das zunehmende Kommunikationsaufkommen stellen immer höhere Anforderungen an den Entwicklungsprozess. Aufgrund der wachsenden Anzahl an vernetzten Funktionen spielt die Betrachtung des Timing-Verhaltens der Systeme eine zentrale Rolle. Die Arbeit beschreibt eine Methodik, welche eine durchgängige Bewertung von Vernetzungsarchitekturen und Gateway-Systemen hinsichtlich deren Timing-Verhaltens ermöglicht.
    Schlagwort(e): T1-995 ; E/E-Architekturen ; Entwicklungsprozess ; Timing ; Vernetzungsarchitekturen ; Gateway-Systeme ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 58
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    La relación médico-paciente (2021)
    Publicacions i Edicions de la Universitat de Barcelona
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: La relación médico-paciente está sometida a varias presiones. La financiación de la asistencia sanitaria puede determinar tanto la percepción colectiva del acceso a los recursos sociales (prestaciones económicas, centros de atención especializada, ayudas a domicilio, entre otros) como la prescripción de medicamentos y de pruebas complementarias. Además de las prioridades del financiador o de los beneficiarios de los resultados económicos, las campañas publicitarias influyen también en el criterio del paciente, al que la industria farmacéutica halaga convenciéndolo de que posee conocimientos de medicina y de que es un consumidor con el poder de escoger, cuando en realidad decide porque tiene los medios económicos para pagar su elección. En este libro se analizan las razones que empujan a los profesionales de la sanidad hacia una parcialidad interesada, así como las consecuencias éticas que ello tiene sobre el individuo y sobre la eficiencia del sistema sanitario.
    Schlagwort(e): R5-920 ; RA1-1270 ; BJ1-1725 ; Relacions metge-pacient ; Medicina ; Dret ; bic Book Industry Communication::M Medicine
    Sprache: Spanisch
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  • 59
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    Sustainable Energy Systems Planning, Integration and Management (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: Energy systems worldwide are undergoing major transformation as a consequence of the transition towards the widespread use of clean and sustainable energy sources. Basically, this involves massive changes in technical and organizational levels together with tremendous technological upgrades in different sectors ranging from energy generation and transmission systems down to distribution systems. These actions generate huge science and engineering challenges and demands for expert knowledge in the field to create solutions for a sustainable energy system that is economically, environmentally, and socially viable while meeting high security requirements. This book covers these promising and dynamic areas of research and development, and presents contributions in sustainable energy systems planning, integration, and management. Moreover, the book elaborates on a variety of topics, ranging from design and planning of small- to large-scale energy systems to the operation and control of energy networks in different sectors, namely electricity, heat, ?and transport.
    Schlagwort(e): TA1-2040 ; T1-995 ; n/a ; Romanian coastal environment ; neural networks ; intermittent heating ; wind velocities ; time-space network ; optimal chiller loading (OCL) ; renewable energy ; pure electric buses ; mixed-integer non-linear programming problem (MINLP) ; control system ; FANP ; energy consumption ; load regulation ; energy ; smart box ; novel method ; smart logistics system ; multiple uncertainties ; non-intrusive load monitoring ; wind speed forecasting ; solid waste to energy plant ; uncertain cooling demand ; dual robust optimization ; Black Sea ; field test and numerical simulation ; electric power ; sustainable development ; multi-type bus operating organization ; cuckoo search algorithm ; vehicular emissions ; SWAN ; public transport ; product quality model ; MCDM ; TOPSIS ; heat transfer ; solar energy ; forecasting validity ; information gap decision theory (IGDT) ; photovoltaic systems ; configurations of internal wall ; ensemble empirical mode decomposition ; agricultural pruning ; hot summer and cold winter climate zone ; energy and environmental systems ; feature extraction ; information platform ; pruning biomass ; smart grid ; product usability testing ; meteorological variables ; fuzzy logic ; performance evaluation ; rural residential building ; threshold value of daily operation hours ; datacenter ; wave energy ; thermal comfort ; heat storage and release ; resampling ; risk aversion ; environment ; support vector machine ; internal coverings ; numerical models ; gradient descent ; renewable biomass energy ; demand response ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
    Format: application/octet-stream
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  • 60
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    Global health issues of aflatoxins in food and agriculture: Challenges and opportunities (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Schlagwort(e): R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 61
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    Marine Compounds and Cancer (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Schlagwort(e): R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    Zum Einfluss von Fahrzeug- und Straßenparametern auf die Ausbildung von Straßenunebenheiten (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Die vorliegende Arbeit untersucht den Einfluss unterschiedlicher Fahrzeug- und Straßenparameter auf die Ausbildung von longitudinalen Straßenunebenheiten. Hierzu wird ein abstrahiertes Fahrzeugmodell zur Abbildung der Vertikaldynamik von Lkw formuliert sowie ein phänomenologisches Gesetz zur Berechnung der bleibenden Straßenverformung verwendet. Mit Hilfe von analytischen und semianalytischen Methoden wird die Entwicklung einzelner Spektralanteile der Straßenoberfläche prognostiziert.
    Schlagwort(e): T1-995 ; Fahrzeugschwingungen ; Längsunebenheiten ; bleibende Verformung ; Parametereinfluss ; Fahrzeug-Straße-Interaktion ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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    Epigenetics of B Cells and Antibody Responses (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Schlagwort(e): R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Schlagwort(e): R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    Saúde, trabalho e formação profissional (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Reúne textos de especialistas das áreas de Saúde e de Educação com longa, competente e comprometida atuação na luta por mudanças sociais, preocupados com um (con)viver humano mais solidário. A obra mostra ser possível a constituição de serviços de saúde com profissionais sensíveis e preparados para atuar em tempos de novas exigências técnicas e de capacitação profissional. Por instigar a (re)pensar o aperfeiçoamento técnico e ético do trabalho, com idéias e propostas originais e atuais, trata-se, certamente, de contribuição de relevância para aqueles que, direta ou indiretamente, encontram-se engajados na causa do Sistema Único de Saúde.
    Schlagwort(e): R5-920 ; Pessoal técnico de saúde-educação ; Ocupação em saúde ; educação profissional ; bic Book Industry Communication::M Medicine
    Sprache: Portugiesisch
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    Funkkanalmodellierung für OFDM-Kommunikationssysteme bei Hochgeschwindigkeitszügen (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: In diesem Buch wird ein drahtloses OFDM-Kommunikationssystem für Hochgeschwindigkeitszüge analysiert, der Funkkanal modelliert und das Modell durch Messungen verifiziert. Mit Hilfe des Kanalmodells können drahtlose Zugkommunikationssysteme unter Berücksichtigung der hohen Zeitvarianz in optimaler Weise ausgelegt werden. Aus der Untersuchung verschiedener Einflüsse werden richtungsweisende Regeln für die Auslegung solcher Systeme abgeleitet und ein entsprechendes OFDM-System vorgeschlagen.
    Schlagwort(e): T1-995 ; Zeitvarianz ; OFDM-System ; Funkkanalmodellierung ; Hochgeschwindigkeitszüge ; drahtlose Kommunikation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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  • 67
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    Effiziente MHz-Wechselrichter mit unipolaren SiC-Transistoren für Hochleistungs-Induktionslampen (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: This work presents the design and investigation of a novel UV-lamp-system, which is based upon UV-induction lamps and a MHz-inverter equipped with normally-on junction field effect transistors (JFET). A system efficiency of some more than 27 % is verified with the prototype UV-induction lamp system, which positions between the two previous UV-systems and open up new fields of application.
    Schlagwort(e): T1-995 ; MHz-Wechselrichter ; Siliziumkarbid ; UV-disinfection ; resonant inverter ; UV-Induktionslampe ; UV-induction lamp ; Resonanzwechselrichter ; silicon carbide ; UV-DesinfektionMHz inverter ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 68
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    Immune responses to AAV vectors, from bench to bedside (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Schlagwort(e): R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    Prüfplanung : ein neues Prozessmanagement für Fahrzeugprüfungen (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Die Arbeit analysiert die Potentiale der Risikoanalyse für die Planung von Prüfungen, Tests und Wartungsmaßnahmen an technischen Systemen. Der Autor beschreibt ein Prozessmanagement zur Prüfplanung, welches die Definition von komponenten- und funktionsbezogenen Qualitätsmerkmalen, die Risikobewertung der Qualitätsmerkmale, sowie einen neuartigen numerischen Priorisierungsalgorithmus umfasst. Die Methode ist generisch formuliert, die Anwendung ist für Personenkraftwagen erläutert.
    Schlagwort(e): T1-995 ; Wartung ; Test ; Fahrzeugprüfung ; Prüfung ; Risikoanalyse ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 70
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    Flow and Transport Properties of Unconventional Reservoirs 2018 (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: Unconventional reservoirs are usually complex and highly heterogeneous, such as shale, coal, and tight sandstone reservoirs. The strong physical and chemical interactions between fluids and pore surfaces lead to the inapplicability of conventional approaches for characterizing fluid flow in these low-porosity and ultralow-permeability reservoir systems. Therefore, new theories and techniques are urgently needed to characterize petrophysical properties, fluid transport, and their relationships at multiple scales for improving production efficiency from unconventional reservoirs. This book presents fundamental innovations gathered from 21 recent works on novel applications of new techniques and theories in unconventional reservoirs, covering the fields of petrophysical characterization, hydraulic fracturing, fluid transport physics, enhanced oil recovery, and geothermal energy. Clearly, the research covered in this book is helpful to understand and master the latest techniques and theories for unconventional reservoirs, which have important practical significance for the economic and effective development of unconventional oil and gas resources.
    Schlagwort(e): TA1-2040 ; T1-995 ; shale gas ; permeability ; prediction by NMR logs ; matrix–fracture interaction ; faults ; remaining oil distributions ; unconventional reservoirs ; coal deformation ; reservoir depletion ; carbonate reservoir ; nanopore ; fracturing fluid ; pseudo-potential model ; shale reservoirs ; matrix-fracture interactions ; multi-scale fracture ; succession pseudo-steady state (SPSS) method ; fluid transport physics ; integrated methods ; chelating agent ; dissolved gas ; non-equilibrium permeability ; effective stress ; fractal ; fracture network ; spontaneous imbibition ; tight oil ; porous media ; 0-1 programming ; the average flow velocity ; geothermal water ; micro-fracture ; pore types ; pore network model ; petrophysical characterization ; nitrogen adsorption ; analysis of influencing factors ; mudstone ; rheology ; velocity profile ; shale permeability ; flow resistance ; global effect ; tight sandstones ; fractal dimension ; contact angle ; temperature-resistance ; fractured well transient productivity ; reservoir classifications ; deep circulation groundwater ; viscosity ; NMR ; fractional diffusion ; lattice Boltzmann method ; multiporosity and multiscale ; fractal geometry ; imbibition front ; productivity contribution degree of multimedium ; wetting angle ; pH of formation water ; enhanced oil recovery ; isotopes ; tight sandstone ; fracture diversion ; shale ; SRV-fractured horizontal well ; low-salinity water flooding ; shale gas reservoir ; tight reservoirs ; fracture continuum method ; tight oil reservoir ; Lucaogou Formation ; hydraulic fracturing ; clean fracturing fluid ; recovery factor ; flow regimes ; local effect ; complex fracture network ; pore structure ; gas adsorption capacity ; polymer ; non-linear flow ; conformable derivative ; production simulation ; analytical model ; enhanced geothermal system ; multi-scale flow ; experimental evaluation ; extended finite element method ; fluid-solid interaction ; groundwater flow ; well-placement optimization ; thickener ; imbibition recovery ; equilibrium permeability ; slip length ; large density ratio ; clay mineral composition ; finite volume method ; volume fracturing ; influential factors ; sulfonate gemini surfactant ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 71
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    Diffraktive Optiken im Automobil - Achromatisierung, Athermalisierung, Formung von Scheinwerferlichtverteilungen (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: The complexity of optical systems in headlamps is increasing rapidly. This leads to new design concepts, but it is also leading to increasing influence of aberrations. This work is dealing with the minimization of chromatical and thermal effects by using diffractive optics. Therefore, a new lens design in combination with the optical simulation of diffractive structures based on ray tracing is presented.
    Schlagwort(e): T1-995 ; Athermalisierung ; headlamp ; Achromatisierung ; diffractive ; athermalization ; Optikachromatization ; Scheinwerfer ; diffraktiv ; optics ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 72
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    Thin Film Transistor (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: Recently, new wide-band energy gap semiconductors can be grown by ALD, PLD, sputtering, or MOCVD. They have great potential for the fabrication and application to TFTs. Inorganic semiconductors have good stability against environmental degradation over their organic counterparts, whereas organic materials are usually flexible, transparent, and when solution-processed at low temperatures, are prone to degradation when exposed to heat, moisture, and oxygen. For this Special Issue, we invited researchers to submit papers discussing the development of new functional and smart materials, and inorganic as well as organic semiconductor materials, such as ZnO, InZnO, GaO, AlGaO, AnGaO, AlN/GaN, conducting polymers, molecular semiconductors, perovskite-based materials, carbon nanotubes, carbon nanotubes/polymer composites, and 2D materials (e.g., graphene, MoS2) and their potential applications in display drivers, radio frequency identification tags, e-paper, gas, chemical and biosensors, to name but a few.
    Schlagwort(e): TA1-2040 ; TK1-9971 ; T1-995 ; charge transport and injection mechanisms ; optical synaptic devices ; flat panel displays ; simulation ; persistent photoconductivity ; hydrogen ; interdigitated ; interface state trap density ; technology computer aided design (TCAD) ; oxygen defects ; Corbino ; transistor model evaluation ; metal-halide lamp ; InGaZnOx ; contact resistances ; chemical treatment ; colour difference ; organic transistor ; equivalent circuit ; channel-length dependence ; just noticeable difference ; oxide semiconductor ; OTFT ; chromaticity ; modeling contact effects ; oxygen deficiency ; dual-threshold inverter ; surface treated ; charge-carrier-mobility extraction ; optical detecting ; thin film transistor ; green ; photo-sensors ; modelling ; capacitor ; TFT-LCD ; organic thin-film transistor ; spectrum ; hydrogen effect ; organic film growth ; transparent conducting oxides ; quartz-halogen lamp ; optical ; blue LED ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 73
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    Image Analysis and Evaluation of Cylinder Bore Surfaces in Micrographs (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: This work presents two image-based inspection approaches for the quality evaluation of cylinder bore surfaces. In the first algorithm, metal folds on plateau-honed surfaces are inspected with scanning electron microscopy. An edge-aware structure tensor is proposed for feature extraction and localization of surface defects. The second algorithm uses a morphgraphical method for detecting graphite grains in optical micrographs. Based on the inspection results, quality parameters are proposed.
    Schlagwort(e): T1-995 ; image processing ; Bildverarbeitung ; Kantendetektion ; Mikrographhoning ; micrograph ; automated vision inspection ; Honung ; edge detection ; Automatische Sichtprüfung ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Englisch
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  • 74
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    Simulation von Fahrspielen und Energieflüssen in Nahverkehrssystemen (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: For ecological und economic reasons, special attention is paid to the energy balance of rail-bound, local, direct current-based transport systems. With the tram and urban railway network of Karlsruhe being used as an example, 16 simulation scenarios with different measures for energy optimization are analysed in a coupled computation of driving cycles and energy flows.
    Schlagwort(e): T1-995 ; energy flow calculation ; driving cycle simulation ; Fahrspielsimulation ; Energieflussberechnung ; local transport system ; Nahverkehrssystem ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 75
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    Ontologie-basierte Definition von Anforderungen an Validierungswerkzeuge in der Fahrzeugtechnik (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: Validation and verification are central activities of product engineering. The aim of these activities is to predict and evaluate the future system behaviour of the product in development. This is achieved by conducting tests and interpreting the generated measurement data. This work introduces an ontology-based method for increasing the efficiency and effectively of innovative automotive development projects, especially in cases where an organisational knowledge base does not exist yet.
    Schlagwort(e): T1-995 ; Wissensmanagement ; Validierung ; ProduktentwicklungAutomobile technology ; knowledge management ; Fahrzeugtechnik ; validation ; product engineering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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  • 76
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    Duktilisierung von Wolfram : Synthese, Analyse und Charakterisierung von Wolframlaminaten aus Wolframfolie (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Der in dieser Arbeit untersuchte Ansatz ist die Duktilisierung von Wolfram durch Synthese eines Wolframlaminats. Da Wolframfolie duktil ist und sich selbst bei Raumtemperatur plastisch verformen lässt, könnte es durch Übereinanderschichten und geeignetes Verbinden mehrerer Folienlagen gelingen, die duktilen Eigenschaften der Wolframfolie auf ein Massivbauteil zu übertragen.
    Schlagwort(e): T1-995 ; Laminate ; Wolfram ; Duktilisierung ; Wolframlaminate ; Wolframfolie ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 77
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    CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Schlagwort(e): R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 78
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    Communicating Medicine (2021)
    Ledizioni
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Schlagwort(e): R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 79
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    Environmental Impact Assessment of Buildings (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: This Special Issue covers a wide range of areas—including building orientation, service life, use of photocatalytically active structures and PV facades, implications of transportation system, building types (i.e., high rise, multilevel, commercial, residential), life cycle assessment, and structural engineering—that need to be considered in the environmental impact assessment of buildings, and the chapters include case studies across the globe. Consideration of these strategies would help reduce energy and material consumption, environmental emissions, and waste generation associated with all phases of a building’s life cycle. Chapter 1 demonstrates that green star concrete exhibits the same structural properties as conventional concrete in Australia. Chapter 2 showed that the use of TiO2 as a photocatalyst on the surface of construction materials with a suitable stable binding agent, such as aggregates, would enable building walls to absorb NOx from air. This study found that TiO2 has the potential to reduce ambient concentrations of NOx from areas where this pollutant becomes concentrated under solar irradiation. Chapter 3 presents the life cycle assessment of architecturally integrated glass–glass photovoltaics in building facades to find the appropriate material composition for a multicolored PV façade offering improved environmental performance. Chapter 4 shows that urban office buildings lacking appropriate orientation experienced indoor overheating. Chapter 5 details four modeling approaches that were implemented to estimate buildings’ response towards load shedding. Chapter 6 covers the life cycle GHG emissions of high-rise residential housing block to discover opportunities for environmental improvement. Chapter 7 discusses an LCA framework that took into account variation in the service life of buildings associated with the use of different types of materials. Chapter 8 presents a useful data mining algorithm to conduct life cycle asset management in residential developments built on transport systems.
    Schlagwort(e): TA1-2040 ; T1-995 ; wash water ; greenhouse gases ; environmental life cycle assessment ; sustainable-development ; transit-policy ; public-engagement ; Multilevel buildings ; building integrated photovoltaic ; slag ; operational energy ; life-cycle social analysis ; building ; travel-satisfaction ; TEASER ; BIPV ; photocatalytic construction materials ; functionalized aggregate ; green star concrete ; work-commute ; shallow plan forms ; life cycle assessment ; recycled aggregate ; environmental remediation ; block of buildings ; rain cladding ; LCA ; sustainability ; peak shaving ; residential building ; indoor overheating ; LCI ; air pollution ; environmental performance ; service life ; nitric oxides ; thermal model ; coloured glass ; demand response ; modal-variability ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 80
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    Três ensaios de bioética (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Leitores interessados no desenvolvimento teórico da bioética e, ao mesmo tempo, em sua aplicação na solução de conflitos morais certamente encontrarão neste livro materiais de grande valor. Cada capítulo coloca a bioética em um contexto diferente: na clínica, na genômica e na biossegurança. No primeiro ensaio, discutem-se as possibilidades dessa ‘caixa de ferramentas’ chamada bioética para compreender e tentar resolver conflitos de interesses e valores no âmbito das relações entre profissionais e usuários dos serviços de saúde. No segundo, o autor aplica as ferramentas da bioética ao caso dos conflitos morais que envolvem a genômica, contemplando argumentos favoráveis e contrários às práticas da engenharia genética e contribuindo para o raciocínio crítico e sem preconceitos sobre o tema. Por fim, o terceiro capítulo trata da interface entre a bioética e a biossegurança, que têm preocupações comuns, como a questão dos riscos, mas abordagens distintas – enquanto a bioética se ocupa dos valores morais, a biossegurança lança mão de medidas técnicas, administrativas e legais.
    Schlagwort(e): R5-920 ; bic Book Industry Communication::M Medicine
    Sprache: Portugiesisch
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  • 81
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    Lipid Signaling in T Cell Development and Function (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Schlagwort(e): R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 82
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    Spaltverhalten von Holz beim Eindrehen von selbstbohrenden Holzschrauben (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: Für Verbindungen im Holzbau werden häufig selbstbohrende Holzschrauben eingesetzt. Diese können oft mit geringen Abständen untereinander und zu den Bauteilrändern angeordnet werden. Durch die Einhaltung von Mindestabständen und Mindestholzdicken soll hierbei ein Versagen des Holzes durch Aufspalten verhindert werden. Im Rahmen dieser Arbeit wurde ein Verfahren entwickelt, mit dem sich die Anforderungen an Abständen und Holzdicken effizienter und zuverlässiger als bisher bestimmen lassen.
    Schlagwort(e): T1-995 ; Mindestabstände ; Holzschrauben ; Holzbau ; Verbindungen ; Spaltversagen ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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  • 83
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    Foundations of Paleoparasitology (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Unprecedented initiative in the world, the book compiles the available knowledge on the subject and presents the state-of-the-art in paleoparasitology – term coined about 30 years ago by Brazilian Fiocruz researcher Luiz Fernando Ferreira, pioneer in this science which is concerned with the study of parasites in the past. Multidisciplinary by essence, paleoparasitology gathers contributions from social scientists, biologists, historians, archaeologists, pharmacists, doctors and many other professionals, either in biomedical or humanities fields. With varied applications such as in evolutionary or migration studies, their results often depend on the association between laboratory findings and cultural remains. The book is divided into four parts - Parasites, Hosts, and Human Environment; Parasites Remains Preserved in Various Materials and Techniques in Microscopy and Molecular Diagnostics; Parasite Findings in Archeological Remains: a paleographic view; and Special Studies and Perspectives. Signed by authors from various countries such as Argentina, USA, Germany and France, the book has chapters devoted to the discoveries of paleoparasitology on all continents.
    Schlagwort(e): R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 84
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    The Effects of Internal Stress and Lithium Transport on Fracture in Storage Materials in Lithium-Ion Batteries (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: Fracture of storage particles is considered to be one of the major reasons for capacity fade and increasing power loss in Li-ion batteries. In this work, we tackle the problem by merging a coupled model of mechanical stress and diffusion of Li-ions with a phase field description of an evolving crack. The novel approach allows us to study the evolution of the Li concentration together with the initiation and growth of a crack in an arbitrary geometry and without presuming a specific crack path.
    Schlagwort(e): T1-995 ; Lithium-Diffusion ; Lithium-Ionen-BatterienCrack Growth ; Storage Particles ; Risswachstum ; Phasefield ; Li-Diffusion ; Phasenfeld ; Li-Ion-Batteries ; Speicherpartikel ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 85
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    Creep and High Temperature Deformation of Metals and Alloys (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: By the late 1940s, and since then, the continuous development of dislocation theories have provided the basis for correlating the macroscopic time-dependent deformation of metals and alloys—known as creep—to the time-dependent processes taking place within the metals and alloys. High-temperature deformation and stress relaxation effects have also been explained and modeled on similar bases. The knowledge of high-temperature deformation as well as its modeling in conventional or unconventional situations is becoming clearer year by year, with new contemporary and better performing high-temperature materials being constantly produced and investigated.This book includes recent contributions covering relevant topics and materials in the field in an innovative way. In the first section, contributions are related to the general description of creep deformation, damage, and ductility, while in the second section, innovative testing techniques of creep deformation are presented. The third section deals with creep in the presence of complex loading/temperature changes and environmental effects, while the last section focuses on material microstructure–creep correlations for specific material classes. The quality and potential of specific materials and microstructures, testing conditions, and modeling as addressed by specific contributions will surely inspire scientists and technicians in their own innovative approaches and studies on creep and high-temperature deformation.
    Schlagwort(e): TA1-2040 ; T1-995 ; TN1-997 ; Larson–Miller parameter ; n/a ; visualization ; bond coat ; hydrogen ; poly-crystal ; Gibbs free energy principle ; constitutive equations ; creep damage ; DFT ; finite element method ; austenitic stainless steel ; strain rate sensitivity ; MCrAlY ; excess volume ; superalloy ; scanning electron microscopy ; creep buckling ; dislocation dynamics ; creep ; elevated temperature ; modelling ; size effect ; residual stress ; superalloy VAT 32 ; water vapor ; activation energy ; small angle neutron scattering ; superalloy VAT 36 ; metallic glass ; iron aluminides ; Gr.91 ; internal stress ; relaxation fatigue ; multiaxiality ; creep grain boundary ; grain boundary cavitation ; cavitation ; solute atom ; stress exponent ; external pressure ; P92 ; TMA ; low cycle fatigue ; nanoindentation ; high temperature ; FEM ; intrinsic ductility ; normalizing ; creep ductility ; creep rupture mechanism ; microstructural features ; simulate HAZ ; P92 steel ; glide ; ferritic–martensitic steel ; creep rupture ; cyclic softening ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 86
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    Konditionierung von biogenen Energieträgern aus den Produkten der bioliq®-Schnellpyrolyse (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: Within the bioliq®-process, the organic phase of straw pyrolysis condensates can be gasified directly, while the aqueous phase can be mixed with char to form a slurry, which also can be gasified. For production and storage, several mixers and stirrers are examined. Grinding the porous and elongated char particles decelerates sedimentation and also reduces the viscosity. Thus, higher concentrated slurries can be mixed, which leads to higher stability.
    Schlagwort(e): T1-995 ; Pyrolysekondensat ; Vergasungchar ; pyrolysis condensate ; gasification ; Suspension ; Mischen ; slurry ; mix ; Koks ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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  • 87
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    Biomedical Insights that Inform the Diagnosis of ME/CFS (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Schlagwort(e): R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
    Format: application/octet-stream
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    Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Schlagwort(e): R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 89
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    Thermal and Electro-thermal System Simulation (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: With increasing power levels and power densities in electronics systems, thermal issues are becoming more and more critical. The elevated temperatures result in changing electrical system parameters, changing the operation of devices, and sometimes even the destruction of devices. To prevent this, the thermal behavior has to be considered in the design phase. This can be done with thermal end electro-thermal design and simulation tools. This Special Issue of Energies, edited by two well-known experts of the field, Prof. Marta Rencz, Budapest University of Technology and Economics, and by Prof. Lorenzo Codecasa, Politecnico di Milano, collects twelve papers carefully selected for the representation of the latest results in thermal and electro-thermal system simulation. These contributions present a good survey of the latest results in one of the most topical areas in the field of electronics: The thermal and electro-thermal simulation of electronic components and systems. Several papers of this issue are extended versions of papers presented at the THERMINIC 2018 Workshop, held in Stockholm in the fall of 2018. The papers presented here deal with modeling and simulation of state-of-the-art applications that are highly critical from the thermal point of view, and around which there is great research activity in both industry and academia. Contributions covered the thermal simulation of electronic packages, electro-thermal advanced modeling in power electronics, multi-physics modeling and simulation of LEDs, and the characterization of interface materials, among other subjects.
    Schlagwort(e): TA1-2040 ; T1-995 ; thermal interface material ; thermal aging ; modeling ; LED compact thermal models ; niobium pentoxide ; model-order reduction ; ferromagnetic cores ; LED digital twin ; Cauer RC ladder ; in-situ characterization ; electronic packages ; time domain thermoreflectance ; multi-domain compact model ; power LEDs ; DC–DC converters ; structure function ; boundary condition independent ; electric aircraft ; multi-LED ; modelling ; light emitting diodes ; thin film ; JEDEC metrics ; tool agnostic ; power losses ; switching ; dynamic thermal compact model ; thermal transient testing ; reliability ; thermal transient analysis ; thermal simulation ; non-destructive testing ; IGBT ; carbon nanotubes ; compact thermal model ; power semiconductor devices ; SPICE ; phosphor light conversion ; thermal management ; LED luminaire design ; design flow ; thermal characterization ; motor cooling ; thermal phenomena ; silicone dome ; LED ; secondary heat path ; multi-domain modelling ; heating and optical power ; transient analysis ; thermal testability ; thermal conductivity ; multiple heat source ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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    Optimization Methods Applied to Power Systems: Volume 2 (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: This book presents an interesting sample of the latest advances in optimization techniques applied to electrical power engineering. It covers a variety of topics from various fields, ranging from classical optimization such as Linear and Nonlinear Programming and Integer and Mixed-Integer Programming to the most modern methods based on bio-inspired metaheuristics. The featured papers invite readers to delve further into emerging optimization techniques and their real application to case studies such as conventional and renewable energy generation, distributed generation, transport and distribution of electrical energy, electrical machines and power electronics, network optimization, intelligent systems, advances in electric mobility, etc.
    Schlagwort(e): TA1-2040 ; T1-995 ; n/a ; Stackelberg game ; MILP ; optimal congestion threshold ; magnetic field mitigation ; simulation ; multi-objective particle swarm optimization ; virtual power plant ; internal defect ; day-ahead load forecasting ; neural network ; modular predictor ; multi-objective particle swarm optimization algorithm ; stochastic optimization ; dragonfly algorithm ; unit commitment ; metaheuristic ; multi-population method (MP) ; optimization ; tabu search ; considerable decomposition ; loss minimization ; active distribution system ; islanded microgrid ; dynamic solving framework ; feature selection ; electric energy costs ; power factor compensation ; dependability ; interactive load ; overhead ; energy internet ; evolutionary computation ; wind power ; developed grew wolf optimizer ; underground ; ETAP ; fuzzy algorithm ; electric vehicles ; Schwarz’s equation ; evolutionary algorithms ; electric power contracts ; congestion management ; optimizing-scenarios method ; building energy management system ; particle encoding method ; ringdown detection ; HOMER software ; DC optimal power flow ; prosumer ; constrained parameter estimation ; distributed generations (DGs) ; strong track filter (STF) ; transient stability ; calibration ; cost minimization ; radiance ; decentralized and collaborative optimization ; hybrid renewable energy system ; renewable energy sources ; rural electrification ; distribution network reconfiguration ; interval variables ; optimization methods ; particle swarm optimization ; hierarchical scheduling ; micro grid ; AC/DC hybrid active distribution ; consensus ; artificial bee colony ; CCHP system ; data center ; support vector machine ; affinity propagation clustering ; extended Kalman filter ; affine arithmetic ; linear discriminant analysis (LDA) ; current margins ; heterogeneous networks ; Cameroon ; hybrid method ; distributed heat-electricity energy management ; discrete wind driven optimization ; fitness function ; cross-entropy ; GenOpt ; wind energy ; demand uncertainty ; UC ; off-design performance ; genetic algorithm ; energy storage ; the biomimetic membrane computing ; power system optimization ; electric vehicle ; power architectures ; economic load dispatch problem (ELD) ; runner-root algorithm (RRA) ; Cable joint ; battery energy storage system ; load curtailment ; integration assessment ; power system unit commitment ; artificial lighting ; power flow ; hybrid membrane computing ; two-point estimation method ; low-voltage networks ; demand bidding ; non-sinusoidal circuits ; energy flow model ; power transfer distribution factors ; sustainability ; HVAC system ; voltage deviation ; street light points ; radial basis function ; energy storage system ; charging/discharging ; power systems ; intelligent scatter search ; MV/LV substation ; optimal power flow ; stochastic state estimation ; eight searching sub-regions ; chaos optimization algorithm (COA) ; mutual information theory ; inter-turn shorted-circuit fault (ISCF) ; C&I particle swarm optimization ; multiobjective optimization ; passive shielding ; sub-Saharan Africa ; micro-phasor measurement unit ; geometric algebra ; bio-inspired algorithms ; adaptive consensus algorithm ; energy management ; PCS efficiency ; multi-stakeholders ; generalized generation distribution factors ; the genetic algorithm based P system ; JAYA algorithm ; thermal probability density ; power optimization ; pumped-hydro energy storage ; smart grid ; two-stage feature selection ; piecewise linear techniques ; photovoltaic ; SOCP relaxations ; switched reluctance machine (SRM) ; optimal reactive power dispatch ; optimal operation ; controllable response ; off-grid ; active shielding ; transformer-fault diagnosis ; IEEE Std. 80-2000 ; principal component analysis ; demand response ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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    Marine Structures (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2022-01-31
    Beschreibung: Structural mechanics is an important field of engineering. The main goal of structural mechanics is to ensure that structures are safe and durable so that catastrophic situations can be prevented, which can otherwise cause loss of life, environmental pollution and financial losses. Depending on the uses of the structure and the conditions that the structure is subjected to, special treatment may be required for the analysis. Specifically, marine structures are subjected to harsh environmental conditions due to the marine environment, which can cause several different damage mechanisms including fatigue and corrosion. This book on “Marine structures” considers a wide range of areas related to marine structures and provides a compilation of numerical and experimental studies related to “Marine structures” research.
    Schlagwort(e): TC1501-1800 ; TA1-2040 ; T1-995 ; shock loads ; n/a ; jacket structures ; protective device ; tripod support structures ; soil-pile-structure interaction ; acoustic metamaterials ; semi-active ; jacket platform ; solitons ; waves ; biofouling ; seawater piping systems ; motion response ; earthquake ; low-frequency sound ; failure mechanism ; free-surface flow ; depressed bottom ; performance prediction ; acoustic band gap ; marine growth ; uncoupled analysis ; towing resistance ; viscous fluid flow ; ice-induced vibration ; superelement ; anti-collision assessment ; peridynamics ; steel ; integrated numerical model ; fairlead position ; reliability ; cross-flow ; coupled analysis ; morphology evolution ; composites ; tuned mass damper ; towing method ; wave loading ; vortex-induced vibration ; coastal protection structures ; structural control ; vortical flow ; critical mass ratio ; flexible pipe ; stochastic modeling ; offshore wind turbine ; hydrodynamics ; high pressure ; offshore integrated meteorological mast (OIMM) ; ice-resistant cone ; sediment transport ; offshore wind ; thermomechanical ; corrosion detection
    Sprache: Englisch
    Format: application/octet-stream
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  • 92
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    Entwicklung supraleitender, strombegrenzender Transformatoren (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Durch den Einsatz von Hochtemperatursupraleitern (HTSL) können Verluste, Volumen und Gewicht von Transformatoren reduziert werden, zudem werden diese aktiv Fehlerstrom begrenzend. In dieser Arbeit wurde die Rückkühlung von YBCO-Bandleitern nach einer Strombegrenzung untersucht. Weiterhin wurde ein Entwurfsgang für HTSL-Transformatoren erstellt und ein 60 kVA-Transformator entworfen und getestet. Darüber hinaus wurde eine Fallstudie zur Energieeinsparung durch HTSL-Transformatoren erstellt.
    Schlagwort(e): T1-995 ; Anwendung der Supraleitung ; YBCO-Bandleiter ; Hochtemperatursupraleitung ; Strombegrenzung ; Transformatoren ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
    Sprache: Deutsch
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  • 93
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    Analyse der mechanischen Randbedingungen zur Adaption der oszillierenden Hinterschneidtechnik an einen Mobilbagger (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: The oscillating disc cutting process has shown excellent results in precisely removing area-limited-concrete structures. Due to the highly dynamic oscillatory motion, the stiffness requirements to the tool structure and the basic machine have to be considered, which is the main purpose of this work. Based on these results, a concept of a mechanical adaption of the oscillating disc cutting process to an excavator attachment tool will be developed and tested on a prototype.
    Schlagwort(e): T1-995 ; system analysis ; MobilbaggerDisc Cutting ; Werkzeugadaption ; Systemanalyse ; stiffness requirement ; Hinterschneidtechnik ; Steifigkeitsanforderung ; Wheeled Excavator ; tool adaption ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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  • 94
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    The Schistosomiasis Vaccine - It Is Time to Stand Up (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis.
    Schlagwort(e): R5-920 ; RC581-607 ; Schistosomiasis ; Schistosoma mansoni ; Schistosoma haematobium ; Type 2 cytokines ; Vaccine ; Immune responses ; Schistosoma japonicum ; Vaccine candidates ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 95
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    Less and Non-invasive Hemodynamic Monitoring Techniques (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: In the perioperative setting and in intensive care medicine, early and effective hemodynamic management including fluid therapy and administration of vasoactive drugs to maintain vital organ perfusion and oxygen delivery is mandatory. Understanding the different approaches in the management of critically ill patients during the resuscitation and further management is essential to initiate adequate context- and time-specific interventions. Optimization of hemodynamic variables to achieve a balance between organ oxygen delivery and consumption is a cornerstone. In general, cardiac output (i.e., the blood flow) is considered a major determinant of oxygen supply and thus its monitoring is regarded helpful. However, indicators of oxygen requirements are equally necessary to assess adequacy of oxygen supply. Currently, more and more less or even totally non-invasive monitoring systems have been developed and clinically introduced, but they require validation in particular clinical settings. Cardiac output monitors and surrogates of organ oxygenation only enable to adequately guide management, as patient’s outcome is determined by acquisition and interpretation of accurate measurements, and finally, suitable management decisions. This Research Topic focuses on the currently available techniques, especially the less and non-invasive ones, in the field of hemodynamic monitoring in the perioperative setting and in critically ill patients while summarizing their advantages and limitations.
    Schlagwort(e): R5-920 ; Blood Pressure ; Cardiovascular dynamics ; goal-directed therapy ; intensive care medicine ; Cardiac Output ; Anesthesiology ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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    Antimicrobial Resistance in Environmental Waters (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publikationsdatum: 2024-04-11
    Beschreibung: This Special Issue on Antimicrobial Resistance in Environmental Waters features 11 articles on the monitoring and surveillance of antimicrobial resistance (AMR) in natural aquatic systems (i.e., reservoirs, rivers), and effluent discharge from water treatment plants to assess the effectiveness of AMR removal and resulting loads in treated waters. Some of the key elements of AMR studies presented in this Special Issue highlight the underlying drivers of AMR contamination in the environment and the evaluation of the hazard imposed on aquatic organisms in receiving environments through ecological risk assessments. As described in this Issue, screening antimicrobial peptide (AMP) libraries for biofilm disruption and antimicrobial candidates are promising avenues for the development of new treatment options to eradicate resistance.
    Schlagwort(e): TA1-2040 ; T1-995 ; TA170-171 ; risk assessment ; reuse water ; Acinetobacter junii ; Escherichia coli ; co-occurrence pattern ; EPS ; wastewater treatment plant ; UV-disinfection ; biofilm ; estuary reservoir ; Environmental Waters ; antibiotic resistance genes ; antimicrobial peptide (AMP) ; wastewater ; tertiary media filtration ; Psl ; antibiotic-resistant strains ; drinking water treatment plants ; water ; sediment ; surface water ; gastrointestinal infections ; Acinetobacter baumannii ; metal resistance genes ; metagenomics ; water reuse ; bacterial community ; antibiotics ; ERIC-PCR ; river-reservoir system ; the Yellow River ; ecological risk assessment ; aquatic environment ; wastewater treatment ; sand settling reservoirs ; antibiotic resistance gene ; environmental ecology ; antibiotic resistance ; ESBL ; water treatment plants ; Pseudomonas aeruginosa ; chlorination ; irrigation water ; exopolysaccharide ; fecal indicator bacteria ; Antimicrobial Resistance ; persistence ; Qingcaosha reservoir ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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    Silicon-Organic Hybrid Platform for Photonic Integrated Circuits (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: We study the potential of the silicon-organic hybrid (SOH) platform for integrated optics. The unique properties of selected organic materials are added to silicon devices made with CMOS-based processes. We investigate the feasibility of this approach by making prototypes of key components in form of photonic integrated circuits: SOH lasers and SOH modulators are designed, fabricated, post-processed, and characterized. Application scenarios are identified.
    Schlagwort(e): T1-995 ; CMOS ; Modulator ; laser ; modulator ; Silizium-Photonik ; Laser ; Detektor ; CMOSsilicon photonics ; detector ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 98
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    Nichtlineare Modellierung von Ferroelektrika unter Berücksichtigung der elektrischen Leitfähigkeit (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: In dieser Arbeit wird ein Simulationswerkzeug zur Untersuchung des komplexen elektromechanischen Verhaltens von Ferroelektrika entwickelt. Es wird ein neues Materialmodell vorgestellt, das die elektrische Leitfähigkeit der Ferroelektrika berücksichtigt. Anhand von anwendungsnahen Beispielen wird der Einfluss der elektrischen Leitfähigkeit untersucht.
    Schlagwort(e): T1-995 ; Ferroelektrika ; Materialmodell ; Finite-Elemente-Methode ; elektrische Leitfähigkeit ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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    Medicamentos no Brasil : inovação e acesso (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publikationsdatum: 2023-12-21
    Beschreibung: Uma das particularidades da área da saúde é pertencer tanto à esfera social quanto à industrial, característica que representa oportunidades e grandes desafios. O livro Medicamentos no Brasil: inovação e acesso tem o objetivo de fomentar o desenvolvimento tecnológico e fortalecer a produção nacional, além de garantir que o conhecimento desses avanços beneficie a população brasileira. Como afirma o ministro da Saúde, José Gomes Temporão, no prefácio: “...inovação não pode estar desligada da idéia de acesso”. Reunindo os pontos de vista da academia, governo e setor produtivo público e privado, com abordagens que privilegiam o contexto nacional e refletem sobre a posição brasileira no cenário internacional, a obra apresenta um diagnóstico da área de medicamentos no país, avalia seus problemas e potencialidades e faz recomendações concretas para superação dos obstáculos e aproveitamento das oportunidades. Cabe destacar que é o segundo volume de uma série sobre pesquisa, desenvolvimento e inovação nos segmentos industriais da saúde, do Projeto Inovação em Saúde (presidência/Fiocruz), cujo primeiro livro é Vacinas, Soros e Imunizações no Brasil.
    Schlagwort(e): R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Sprache: Portugiesisch
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    Biegefestigkeit von Brettschichtholz-Hybridträgern mit Randlamellen aus Buchenholz und Kernlamellen aus Nadelholz (2021)
    KIT Scientific Publishing
    Details
    Publikationsdatum: 2024-04-09
    Beschreibung: In der Forschungsarbeit wird die Verwendung von Nadelholz statt Buchenholz im weniger biegebeanspruchten Kernbereich von Brettschichtholz untersucht. Es wird anhand von Versuchen und mithilfe von numerischen Methoden gezeigt, dass sich mit so genannten Hybridträgern hohe Festigkeitswerte und geringere Materialkosten als bei reinen Buchenträgern miteinander vereinen lassen.
    Schlagwort(e): T1-995 ; Fichte ; Tan ; Brettschichtholz ; Keilzinkung ; Vollwandträger ; Rotbuche ; Biegefestigkeit ; Nadelholz ; Buchenholz ; Fichtenholz ; Elastizitätsmodul ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Deutsch
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