ISSN:
1432-1254
Keywords:
Rats
;
Naproxen
;
Hypoxia
;
Organ weight
Source:
Springer Online Journal Archives 1860-2000
Topics:
Geography
,
Physics
Notes:
Abstract Rats were exposed intermittently for 8h per day over 6 days at simulated high altitude of 20 000 feet. One group of altitude-exposed animals was treated with naproxen, a prostaglandin inhibiting drug. Significant reduction in body weight gain was observed in both altitude-exposed and drug-treated altitude-exposed animals compared to the control group. Right and left ventricular weights and weights of the adrenal glands were increased significantly in altitude-exposed and altitude-exposed drug-treated animals. The weight of the spleen was increased significantly in altitude-exposed animals whereas no such increase of splenic weight was observed in drug-treated altitude-exposed group of animals. On the other hand, the weight of the liver was decreased significantly in both cases. In drug-treated altitude-exposed animals, the unaltered splenic weight was thought to be due to inhibition of the erythropoietic activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01093453
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