ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

Digitale Medien

Former prime minister to stand for top WHO post (1997)

Brown, Phyllida

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 481-482

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Gro Harlem Brundtland, Norway's former prime minister, has announced that she is willing to stand for election for the post of director-general of the World Health Organization. The UN agency's executive board, made up of health specialists from member states, will vote on the appointment next ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-481b

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2

Digitale Medien

Senate ban on euthanasia splits Australia's doctors (1997)

Ban, Elizabeth

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 479-479

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Australia's medical community has been deeply divided by the Senate's decision to overturn the world's first law allowing voluntary euthanasia. The Northern Territory's Rights of the Terminally I11 Act 1995, which came into effect last summer, was thrown out by the Senate before Easter in an ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-479b

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3

Digitale Medien

Genetic privacy bill “may hinder research” (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 481-481

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A bill before Congress that seeks to protect people's genetic privacy has run into unexpected opposition — from members of the science and biotechnology communities. Although scientists strongly support the section of the bill that aims to prevent genetic discrimination in the workplace ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-481a

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4

Digitale Medien

A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart (1997)

Blankesteijn, W. Matthijs ; Essers-Janssen, Yvonne P.G. ; Verluyten, Monique J.A. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 541-544

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Myocardial infarction results in the formation of granulation tissue in the injured ventricular wall. This tissue contains myofibroblasts in highly organized arrays; their contractile properties may help to prevent the infarct area from dilatation. The mechanisms that control myofibroblast ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-541

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5

Digitale Medien

Sunlight and skin cancer: Inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens (1997)

Ananthaswamy, Honnavara N. ; Loughlin, Susan M. ; Cox, Patricia ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 510-514

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] UV-induced mutations in the p53 tumor suppressor gene play an essential role in skin cancer development. We report here that such mutations can be detected in UV-irradiated mouse skin months before the gross appearance of skin tumors. Application of SPF-15 sunscreens to mouse skin before each UV ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-510

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6

Digitale Medien

Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination (1997)

Boyer, Jean D. ; Ugen, Kenneth E. ; Wang, Bin ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 526-532

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Novel approaches for the generation of more effective vaccines for HIV-1 are of significant importance. In this report we analyze the immunogenicity and efficacy of an HIV-1 DNA vaccine encoding env, rev and gag/pol in a chimpanzee model system. The immunized animals developed specific cellular and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-526

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7

Digitale Medien

Targeting gene expression to hypoxic tumor cells (1997)

Dachs, Gabi U. ; Patterson, Adam V. ; Firth, John D. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 515-520

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as celts in this environment often survive radiation and chemotherapy. In this report we describe how this hypoxic environment can be used to activate heterologous gene expression driven by a hypoxia-responsive element ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-515

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8

Digitale Medien

Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice (1997)

Iafrati, Mark D. ; Karas, Richard H. ; Aronovitz, Mark ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 545-548

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The atheroprotective effects of estrogen in women are well recognized1, but the underlying mechanisms responsible are not well understood. Blood vessel cells express the classic estrogen receptor, ERα (ref. 2—6), and are directly affected by estrogen, which inhibits the development of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-545

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9

Digitale Medien

HIV CCR5 resistance incomplete (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 372-373

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Hopes that some people might be genetically protected from infection with HIV have been dampened by the findings of researchers in Australia. The findings confirm the fears of many scientists, who had warned people against abandoning safer sex on the basis of these hopes. Last year there was ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-372b

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10

Digitale Medien

Gel microdrop technology for rapid isolation of rare and high producer cells (1997)

Weaver, James C. ; McGrath, Patrica ; Adams, Sharlene

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 583-585

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Increasing use of monoclonal antibodies and recombinant proteins has created a demand for methods that accelerate and simplify generation of stable cell lines. Mammalian cell-line development involves isolation or engineering of protein-secreting cells and screening for specificity and high ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-583

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11

Digitale Medien

HIV-1 antibody : debris or virion? (1997)

Parren, Paul W.H.I. ; Burton, Dennis R. ; Sattentau, Quentin J.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 366-367

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — Many hypotheses have been put forward to explain the inability of an antibody response to clear or control HIV-1 infection. These include viral variation, lack of efficacy against cell-to-cell spread and the inhibition of activity at certain privileged anatomical sites. We ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-366d

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12

Digitale Medien

Transmission of L. infantum by blood donors (1997)

Kubar, Joanna ; Quaranta, Jean-François ; Marty, Pierre ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 368-368

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — The possible transmission of Leishmania via blood transfusion was raised by the World Health Organization in 1990. We screen blood from donors to the Monaco Blood Bank who live in areas endemic for L. infantum, checking for potential asymptomatic Leishmania carriers and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-368

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13

Digitale Medien

Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice (1997)

Klein, Karen A. ; Reiter, Robert E. ; Redula, James ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 402-408

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Prostate cancer mortality results from metastasis to bone and hormone-independent tumor growth. Models to study these progressive changes are lacking. Here we describe the propagation of advanced human prostate cancer by direct transfer of surgical samples from patients into immune-deficient male ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-402

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14

Digitale Medien

Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A (1997)

Steiner, Joseph P. ; Connolly, Maureen A. ; Valentine, Heather L. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 421-428

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We show that the nonimmunosuppressive analogues of the immunosuppressive drugs FK506, rapamycin and cyclosporin A promote neurite outgrowth both in PC12 cells and sensory neu-ronal cultures of dorsal root ganglia with potencies resembling their immunosuppressive homologues. Neurotrophic potencies ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-421

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15

Digitale Medien

Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth (1997)

Tanaka, Toshihide ; Manome, Yoshinobu ; Wen, Patrick ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 437-442

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Chronic systemic delivery of therapeutic proteins, such as inhibitors of angiogenesis, present a number of difficult pharmacological challenges. To overcome these problems for one such protein, we constructed retroviral and adenoviral vectors that express a novel, secretable form of the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-437

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16

Digitale Medien

Elevation of oxygen release by nitroglycerin without an increase in blood flow in the hepatic microcirculation (1997)

Kosaka, Hiroaki ; Seiyama, Akitoshi

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 456-459

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The effect of nitroglycerin on oxygen (O2) release in the microcirculation was investigated by examining single, unbranched hepatic sinusoids of rats using dual-spot microspectroscopy. Nitroglycerin significantly increased O2 release from erythrocytes flowing in the sinusoids. Differences in O2 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-456

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17

Digitale Medien

Dying in a Japanese Hospital (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 463-464

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] by Fumio Yamazaki The Japan Times, ISBN: 4-7890-0845-2 Reviewed by Yusuke Nakamura, Director, Human Genome Center, Laboratory of Molecular Medicine, 1-37-1 Kami-ikebukuro, Tokyo 108, Japan Most terminal cancer patients in Japan have to fight for their lives without knowing the truth; they are ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-463b

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18

Digitale Medien

Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease (1997)

Deacon, Terrence ; Schumacher, James ; Dinsmore, Jonathan ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 350-353

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The movement disorder in Parkinson's disease results from the selective degeneration of a small group of dopaminergic neurons in the substantia nigra pars compacta region of the brain. A number of exploratory studies using human fetal tissue allografts have suggested that transplantation of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0397-350

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19

Digitale Medien

Engineering herpes simplex virus vectors for gene transfer to neurons (1997)

Fink, David J. ; Giorioso, Joseph C.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 357-359

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The delivery and expression of transgenes will require individualized approaches tailored to the specific disease and target tissue. For the central and peripheral nervous system, where neurons are postmitotic and intricate cell–cell relationships and regional specialization complicate ex ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0397-357

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20

Digitale Medien

On the market (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 362-364

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] AUTOMATION Interior view of the Mantis bioprocessing system showing the robotic system in close-up with ‘picking’ head in place. The Mantis standalone, multifunctional robotic bioprocessing system from Linear Drives is designed to provide high speed and accurate and automated gridding ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0397-362

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21

Digitale Medien

Some UK medical schools make the grade (1997)

Dickson, David

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 133-133

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The leaders of Britain's medical schools are engaged in an intense round of navel-gazing following a mixed report card on their research efforts that has emerged from a nationwide review of the quality of research in Britain's universities. Organized by the Higher Education Funding Council for ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-133

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22

Digitale Medien

TNF antibodies get new lease (1997)

McSweegan, Edward

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 130-130

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Attempts by biotech companies to market antibody-based therapies for septic shock have been repeatedly beaten back by dismal clinical results and a skeptical US Food and Drug Administration (FDA). “It's sepsis 5, biotech 0,” said one stock analyst, referring to the clinical and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-130a

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23

Digitale Medien

Testing, testing … testing? (1997)

Brower, Vicki

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 131-132

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] With the commercialization of four genetic tests for breast cancer, it would be reasonable to expect a degree of clarity about risk, prevention and treatment of the disease. Instead, the tests “have opened a Pandora's box” of medical and ethical questions, according to one genetic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-131

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24

Digitale Medien

Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells (1997)

Ledda, M. Fernanda ; Adris, Soraya ; Bravo, Alicia I. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 171-176

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Acquisition of invasive/metastatic potential is a key event in tumor progression. Cell surface glycoproteins and their respective matrix ligands have been implicated in this process. Recent evidence reveals that the secreted glycoprotein SPARC (secreted protein, acidic and rich in cysteine) is ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-171

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25

Digitale Medien

Accommodation of vascularized xenografts: Expression of “protective genes” by donor endothelial cells in a host Th2 cytokine environment (1997)

Bach, Fritz H. ; Ferran, Christiane ; Hechenleitner, Paul ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 196-204

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Organ xenografts under certain circumstances survive in the presence of anti-graft antibodies and complement, a situation referred to as “accommodation.” We find that the endothelial cells (ECs) in hamster hearts that accommodate themselves in rats express genes, such as A20 and bcl-2, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-196

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26

Digitale Medien

Expression of cell-cycle regulators p27 Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients (1997)

Porter, Peggy L. ; Malone, Kathleen E. ; Heagerty, Patrick J. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 222-225

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Mutations in certain genes that regulate the cell cycle, such as p16 and p53, are frequently found in human cancers1. However, tumor-specific mutations are uncommon in genes encoding cyclin E and the CDK inhibitor p27Kip1, two cell-cycle regulators that are also thought to contribute to tumor ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-222

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27

Digitale Medien

Typhoid Mary: Captive to the Public's Health (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 241-242

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] by Judith Walzer Leavitt Beacon Press 1996 ISBN: 0-8070-2102-4 $25.00 REVIEWED BY JAMES CURRAN Dean, Rollins School of Public Health, Emory University, 1518 Clifton Rd. NE, Atlanta, GA, 30322 Why don't we treat HIV/AIDS like every other disease? Why shouldn't all carriers of dangerous ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-241b

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28

Digitale Medien

Puzzling over prion partners (1997)

Mitchell, Alison

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1322-1322

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To understand what goes wrong in disease, we often need to know how the biological systems usually operate and work backward from there. The study of transmissible spongiform encephalopathies (TSEs)—such as bovine spongiform encephalopathy, Creutzfeldt-Jakob disease and scrapie—is no ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1297-1322

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29

Digitale Medien

Regeneration in the adult central nervous system: Experimental repair strategies (1997)

Olson, Lars

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1329-1335

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Genes dictate development of the major cytoarchitectonic plan comprising the central nervous system. During formation, this plan may become disturbed for a variety of reasons, but once development is completed, the principle wiring diagram remains fixed. At the level of a single neuron and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1297-1329

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30

Digitale Medien

AMA aims for ethical high road following Sunbeam disaster (1997)

Brower, Vicki

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1183-1183

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In an effort to clean house following its debacle with Sunbeam (Delray Beach, FL), the American Medical Association (AMA) announced the departure of three executives key to the ill-fated endorsement deal. A week later it publicized a plan to gather a panel of nationally known medical ethicists to ...

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URL: http://dx.doi.org/10.1038/nm1197-1183a

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$34 million neuropeptide deal (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1183-1183

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Neuropeptide research is becoming increasingly valuable, not only in terms of its contribution to medical science but also in terms of hard cash. Warner Lambert recently signed a $34 million deal with New Jersey based Synaptic Pharmaceuticals to “advance research on the central ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1197-1183c

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DNA Simplified: The Hitchhiker's Guide to DNA (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1409-1409

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] by Daniel H. Farkas AACC Press, Washington, DC, 104 pp. ISBN 0-915274-84-1 Reviewed by Carina Dennis Assistant Editor, Nature Genetics “If you are good in the kitchen, you're good in the laboratory and vice versa”, according to Daniel Farkas, in his latest book, DNA Simplified: The ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1297-1409a

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Mass spectrometry from miniaturized arrays for full comparative DNA analysis (1997)

Little, Daniel P. ; Braun, Andreas ; O'Donnell, Maryanne J. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1413-1416

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The wealth of genetic information stemming from the Human Genome Project has broad implications impacting biomedical and pharmaceutical research1. A critical cornerstone is defining the role of gene function as a contributor to etiology of diseases, but making such correlations is complex given the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1297-1413

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Dimers are a girl's best friend (1997)

Rowland-Jones, Sarah

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1199-1200

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] NOT EVERYONE EXPOSED to HIV develops the circulating antibodies that are the hallmark of persistent infection and ultimate immunological collapse. Reaching a better understanding of how some people resist HIV infection should provide valuable clues in the search for an effective vaccine. The ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1197-1199

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The UK endorses DIY genetic screening (1997)

Dickson, David

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1180-1180

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The UK has become one of the first countries in the world to endorse mail-order genetic screening. But in doing so, the Department of Health has announced a stringent list of requirements that it says it will expect to be met by any company planning to market genetic screening tests directly to the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1197-1180

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A novel protein that participates in nonself discrimination of malignant cells by homologous complement (1997)

Matsumoto, Misako ; Takeda, Junji ; Inoue, Norimitsu ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1266-1270

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The human complement (C) system protects an individual against substances of nonself origin, including xenografts and microbial pathogens1. Human cells express C-regulatory proteins, CD46 and CD55, thereby circumventing attack by C3, a major effector of C (ref. 2). Nevertheless, certain malignant ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1197-1266

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On the market (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1297-1299

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] UNDER THE HAMMER Going, Going … Sold is a new auction service on the World Wide Web specializing in used and refurbished laboratory equipment. This new service, offered by Internet Auctioneers International, is said to offer significant advantages over conventional sales methods for both ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1197-1297

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Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels (1997)

Ashcroft, Gillian S. ; Dodsworth, Joanne ; Boxtel, Egon Van ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1209-1215

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The cellular and molecular mechanisms underlying the effects of aging on human cutaneous wound healing are poorly understood, and the possible role of reproductive hormones in this process has never been investigated. We report that aging in healthy females was associated with a reduced rate of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1197-1209

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CCR2 chemokine receptor and AIDS progression (1997)

Smith, Michael W. ; Carrington, Mary ; Winkler, Cheryl ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1052-1053

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Recently we reported an association between the CCR2-64I chemokine receptor mutation and delayed onset of AIDS1. Michael et al. have now examined the San Francisco Mens Health Study (SFMHS) AIDS cohort for CCR2 genotypes and in this issue of Nature Medicine report that they fail to detect the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1097-1052c

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From human rights to the human genome : stopping biopiracy (1997)

Brower, Vicki

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1056-1056

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Genetic research by academic institutions and biotechnology companies around the globe is yielding long-sought-after clues to mutations that could help cure a wide range of diseases. This research is being increasingly conducted on tissue samples from native populations known to have increased ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1097-1056b

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Osteopetrosis in mice lacking NF-κB1 and NF-κB2 (1997)

Iotsova, Violetta ; Caamaño, Jorge ; Loy, James ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1285-1289

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The nfkbl and nfkb2 genes encode closely related products regulating immune and inflammatory responses1–3. Their role during development and differentiation remains unclear. The generation of nfkb1 null mice (p50−/−) resulted in altered immune responses, but had no effect on ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1197-1285

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Sex, Race, and Science (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1292-1293

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] EUGENICS IN THE DEEP SOUTH by Edward J.Larson Johns Hopkins University Press, Baltimore, $14.95,251 pp. ISBN 0-80185-511-X, 1996 REVIEWED BY JON BECKWITH American Cancer Society Research Professor, Harvard Medical School, Boston, MA 02115 Halfway through reading Edward Larson's ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1197-1292

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Next year's Nobels? (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1051-1051

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Albert Lasker Medical Research Awards were established in 1946 to celebrate scientists, physicians and public servants whose accomplishments have had a major impact on the treatment or understanding of disease. Nature Medicine is delighted to be publishing commentaries penned by the three 1997 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1097-1051b

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Italian mental hospitals closer to closing? (1997)

Frattura, Lucilla ; D'Avanzo, Barbara

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1054-1054

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — As reminded by Nature Medicine1, the threat of central government sanctions have put further pressure on the Italian Regions to close all remaining psychiatric hospitals (PH) as part of the country's bold 1978 plan to revolutionize its care of the mentally ill by releasing ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1097-1054

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Gastrogenomic delights: A movable feast (1997)

Eisen, Jonathan A. ; Kaiser, Dale ; Myers, Richard M.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1076-1078

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] RECENTLY, WE BIOLOGISTS have been treated to a feast of the complete genome sequences of two gut bacteria: Helicobacter pylori reported by Tomb et al.1 in Nature and Escherichia coli reported by Blattner et al.2 in Science. Complete sequences of eight microbes have now been published (Table 1), and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1097-1076

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bFGF and tumor angiogenesis : Back in the limelight? (1997)

Rak, Janusz ; Kerbel, Robert S.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1083-1084

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] RESEARCH ON TUMOR angiogenesis, which began in earnest 25 years ago, is hot news. This was not the case until relatively recently, so why the big change? The answer can be traced to the discovery and molecular characterization of a diverse family of regulators of angiogenesis, both stimulators and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1097-1083

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GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes (1997)

Stenbit, Antine E. ; Tsao, Tsu-Shuen ; Li, Jing ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1096-1101

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] GLUT4, the insulin-responsive glucose transporter, plays an important role in postprandial glucose disposal. Altered GLUT4 activity is suggested to be one of the factors responsible for decreased glucose uptake in muscle and adipose tissue in obesity and diabetes. To assess the effect of GLUT4 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1097-1096

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Various views on anonymity (1997)

Swift, Michael

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 2-2

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — It is my observation that the quality of manuscript reviews has decreased dramatically over the past five years. Reviewers with professional or economic conflicts of interest, or even mere personal animus, will say anything to block or to delay publication of important ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0197-2e

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Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier (1997)

Bomsel, Morgane

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 42-47

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Contact between various epithelial cell lines and HIV chronically infected mononuclear cell lines results in a massive and rapid budding of HIV virions toward the epithelium followed by their internalization into epithelial endosome-like structures. Here it is shown that as early as 30 min utes ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0197-42

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Commissioner Kessler's activist legacy (1997)

Cimons, Marlene

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 6-7

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] David A. Kessler, whose aggressive and controversial six-year tenure as commissioner of the US Food and Drug Administration (FDA) touched the lives of virtually every American consumer, will return to private life in February. He leaves an agency largely restored to its original mission as a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0197-6

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Inositol prevents folate-resistant neural tube defects in the mouse (1997)

Greene, Nicholas D.E. ; Copp, Andrew J.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 60-66

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Clinical trials demonstrate that up to 70% of neural tube defects (NTDs) can be prevented by folk acid supplementation in early pregnancy, whereas the remaining NTDs are resistant to folate. Here, we show that a second vitamin, myo-inositol, is capable of significantly reducing the incidence ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0197-60

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In the image and likeness of God: Always? (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 7-7

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] “It is not the role of the state to decide who shall live and who shall die.” These words, spoken by Joseph Cardinal Ratzinger (prefect of the Roman Catholic Church's Congregation for the Doctrine of the Faith) opened a remarkable conference held recently in Vatican City. Entitled ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0197-7a

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Politicians call halt to “drive-through” mastectomies (1997)

Brower, Vicki

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 479-479

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] New York has become the first state to ban “drive-through” mastectomy — the surgical treatment of breast cancer as an outpatient procedure. The state law, passed last month, comes ahead of a proposed federal bill that aims to stop this increasing practice in the USA. Media ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-479a

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Britain plans for research into primary care (1997)

Dickson, David

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 480-480

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Keen to see the National Health Service deliver what it calls “evidence-based” medicine, the British government has launched a major initiative designed to boost research into primary health care. Its goals range from increasing the effectiveness of nursing care to determining what ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-480a

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T-cell homeostasis in HIV infection is neither failing nor blind: Modified cell counts reflect an adaptive response of the host (1997)

Grossman, Zvi ; Herberman, Ronald B.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 486-490

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The decisive pathological processes associated with HIV disease occur in infected lymphoreticular tissues (LT). Because our ability to sample these sites is limited, the blood compartment necessarily serves as a window on these processes. Changes in viral load and in T-cell counts, which occurred ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-486

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Chromosomal breakpoints hit the spot (1997)

Rabbitts, Terence H.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 496-497

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] THE IMPORTANCE OF chromosomal abnormalities in tumor development has been clear since pioneering cytogenetic studies successfully defined recurrent changes in specific types of tumors. The concept that proto-oncogenes or suppressor genes are involved in the various forms of microscopically ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-496

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Neurotrophic factor therapy : Keeping score (1997)

Hefti, Franz

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 497-498

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] THE THERAPEUTIC BENEFITS of neurotrophic factors have been proclaimed for several years. Unfortunately, their clinical track record so far has not been impressive. Both ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) failed to benefit amyotrophic lateral sclerosis ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-497

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HIV infection induces changes in CD4 + T-cell phenotype and depletions within the CD4 + T-cell repertoire that are not immediately restored by antiviral or immune-based therapies (1997)

Connors, Mark ; Kovacs, Joseph A. ; Krevat, Seth ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 533-540

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Changes in CD4+ T-cell surface marker phenotype and antigen receptor (TCR) repertoire were examined during the course of HIV infection and following therapy. A preferential decline in naive CD4+ T cells was noted as disease progressed. Following protease inhibitor therapy, naive CD4+ T cells ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-533

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Cancer Therapeutics: Experimental And Clinical Agents (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 581-582

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] edited by Beverly A. Teicher The Humana Press ISBN: 0-89603-460-7, 1996, $125.00 REVIEWED BY JOYCE M. SLINGERLAND Divisions of Medical Oncology and Cancer Biology Research, Toronto Sunnybrook Regional Cancer Center, University of Toronto, Toronto, ON M4N 3M5, Canada This book describes ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0597-581

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Less stress : more pressure? (1997)

Soreq, Hermona ; Kaufer, Daniela ; Friedman, Alon

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 366-366

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Friedman et al. reply — We find Fishman's suggestion logical and we regret not having cited his work5. Our work2 explored the possibility that pyridostigmine, previously considered to be excluded from the cerebrospinal fluid, reaches the brain when administered under stress conditions. We ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-366b

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HIV-1 : co-receptors binding (1997)

Jiang, Shibo

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 367-368

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — Cocchi et al. reported that a HIV-1 chimeric construct (designated HXB2[BaL V3]), in which the entire gp120 V3 domain of HIV-1 HXB2 was replaced by that of HIV-1 BaL, was highly susceptible to suppression of virus replication mediated by C-C chemokines ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-367

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Reactions to cloning (1997)

Cimons, Marlene

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 370-370

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Washington… Reacting to the recent announcement that researchers at the Roslin Institute in Scotland have successfully cloned a sheep from an udder cell taken from an adult ewe (see Nature 385, 810; 1997), US President Bill Clinton has banned the use of government money for human cloning ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-370a

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… and Britain considers impact on life insurance (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 371-371

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] British insurance companies have drawn mixed reviews for their joint decision to accept a two-year moratorium on the use of genetic information in assessing life insurance premiums for individuals seeking house mortgages of up to £100,000 (US$160,000). The proposed moratorium is the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-371b

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NY hospitals win education subsidy (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 372-372

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] No one likes to be compared with a bushel of corn but that is the way medical residents will be counted in New York State for the next six years. In an inventive plan to cushion themselves against sweeping changes in the way physician-training is funded, the state's research hospitals have ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-372a

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Japan forges ahead on artificial organs (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 373-373

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] With human organs in short supply and xenotransplantation facing serious safety concerns, countries around the world are struggling to find solutions. Nature Medicine presents reports from japan, Brazil and the United States. Japan looks set to lead the search for a radical alternative to organ ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-373

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Multidrug resistance : a multiplex phenomenon (1997)

Baldini, Nicola

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 378-380

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] DRUG RESISTANCE IS a common clinical problem in the treatment of human cancer. Resistance to multiple antineoplastic agents may be present before treatment (intrinsic resistance) or can develop during chemotherapy (acquired resistance). In vitro, multidrug resistance is a well-defined phenomenon of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-378

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Digitale Medien

Managed care for viruses (1997)

Crystal, Ronald G.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 383-384

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] IF MANAGED CARE IS an economic strategy to make use of existing medical resources in the most frugal fashion possible, then this paradigm could well be based on the approach taken by group B coxsackie viruses and the adenovirus serotypes 2 and 5 to gain entry to their target cells. Bergelson and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-383

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Thyroiditis and hepatitis: Fas on the road to disease (1997)

French, Lars E. ; Tschopp, Jürg

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 387-388

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] THE FAS RECEPTOR (Fas, CD95, APO-1) and its natural ligand (FasL, CD95L) are transmembrane proteins that belong to the tumor necrosis factor family of receptors and ligands1. Upon engagement with FasL, cells expressing Fas rapidly undergo apoptosis by way of an intracellular signaling pathway ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-387

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… and home on the farm (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 370-371

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] When is an embryo not an embryo? This apparently simple question has come to play a key role in determining whether regulations passed by the British Parliament in 1990 are sufficiently broad to allow the government to ban all forms of human cloning. Ian Wilmut (right) of the Roslin Institute and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-370b

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Japan considers ethics of genetic screening (1997)

Nathan, Richard

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 371-371

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Japan has been been catapulted into an overdue debate on the ethical implications of genetic screening, by protests over a set of guidelines for the detection of hereditary diseases in artificially fertilized eggs. The guidelines were being considered by the Japan Society of Obstetrics and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-371a

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Rational design of vaccines (1997)

Rappuoli, Rino

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 374-376

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A few years ago Sir Gustav Nossal reported in a book that during the fifties the Nobel Prize winner Joshua Lederberg “frequently voiced the view that the presently available vaccines were a scandal.” He questioned “how could we inject our children with the horrible mixture of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-374

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Gene therapy for motor neuron disease (1997)

Sendtner, Michael

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 380-381

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] NEUROTROPHIC FACTORS HAVE long been considered potential candidates for treating human motor neuron diseases such as amyotrophic lateral sclerosis (ALS)1. The discovery that insulin-like growth factor type I (IGF-I) supports motor neuron survival and regeneration and the cloning of genes for two ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-380

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73

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Fibrillation, chaos and clinical control (1997)

Lab, Max J.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 385-386

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] CARDIAC FIBRILLATION, DEFINED as highly disorganized electrical activity in heart muscle that leads to ineffective contractions of the atria and ventricles, is the major cause of sudden cardiac death. Although fibrillation is one of the foremost killers in the developed world, progress in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-385

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Identification of compounds with preferential inhibitory activity against low-Nm23-expressing human breast carcinoma and melanoma cell lines (1997)

Freije, José M.P. ; Lawrence, Julia A. ; Hollingshead, Melinda G. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 395-401

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We have used the COMPARE computer algorithm and Nm23 expression as a marker of tumor metastatic potential to examine the in vitro antiproliferative activity of chemotherapeutic drugs on human breast carcinoma and melanoma cell lines. None of 171 compounds in clinical use or under development and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-395

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Essential roles of the Fas ligand in the development of hepatitis (1997)

Kondo, Toru ; Suda, Takashi ; Fukuyama, Hidehiro ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 409-413

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Fas ligand (FasL) is expressed in activated T cells and induces apoptosis in Fas-bearing cells. A cytotoxic T lymphocyte (CTL) clone specific for hepatitis B surface antigen (HBsAg) causes an acute liver disease in HBsAg transgenic mice. Here we observed that the CTL clone killed hepatocytes ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-409

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76

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Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors (1997)

Haase, G. ; Kennel, P. ; Pettmann, B. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 429-436

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy cause progressive paralysis, often leading to premature death. Neurotrophic factors have been suggested as therapeutic agents for motor neuron diseases, but their clinical use as injected recombinant ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-429

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Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470 (1997)

Klauber, Nancy ; Rohan, Richard M. ; Flynn, Evelyn ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 443-446

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Angiogenesis, the growth of new blood vessels, occurs normally in female reproductive organs. We tested the hypothesis that angiogenesis inhibition may affect fertility by studying the reproductive system in either pregnant or nonpregnant cycling mice after treatment with the angiogenesis inhibitor ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0497-443

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78

Digitale Medien

Cytokines and the acute respiratory distress syndrome (ARDS): A question of balance (1997)

Martin, Thomas R.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 272-273

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] ISAAC NEWTON'S THIRD Law of Motion is as germane to inflammation as it is to the interactions between two physical bodies. For every agonist, there is an equal and opposite antagonist that tends to restore the balance of the forces unleashed in the acute inflammatory response. In this issue ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0397-272

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79

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Narrowing the focus on retinal degeneration (1997)

Steele, Fintan R.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 280-280

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] THE MAMMALIAN RETINA is arguably the most beautiful — and fragile — tissue in the body. A thin wisp of well-defined and highly specialized nerve cells, the retina translates information provided by sunlight into electrical activity that our brains can understand. However, despite our ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0397-280

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Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts (1997)

Bohl, Delphine ; Naffakh, Nadia ; Heard, Jean Michel

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 299-305

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We investigated tetracycline regulation of gene expression in an experimental model relevant to gene therapy. Mouse primary myogenic cells were engineered for doxycycline-inducible and skeletal muscle-specific expression of the mouse erythropoietin (Epo) cDNA by using two retrovirus vectors. Gene ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0397-299

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81

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Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome (1997)

Donnelly, Seamas C. ; Haslett, Chris ; Reid, Peter T. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 320-323

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has the potential to override the anti-inflammatory action of glucocorticoids. In this study we have identified significant quantities of MIF in the alveolar airspaces of patients with acute respiratory ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0397-320

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82

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The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication (1997)

Chinnaiyan, Arul M. ; Woffendin, Clive ; Dixit, Vishva M. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 333-337

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Accelerated programmed cell death, or apoptosis, contributes to the CD4+ T-cell depletion characteristic of infection by human immunodeficiency virus (HIV). It has therefore been proposed that limiting apoptosis may represent a therapeutic modality for HIV infection. We found, however, that T ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0397-333

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83

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High-throughput DNA analysis by time-of-flight mass spectrometry (1997)

Monforte, Joseph A. ; Becker, Christopher H.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 360-362

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Progress in medicine and genomics research has increased the desire for ever faster genetic analysis tools, outstripping the capacity of existing technology. Characteristics that need to be measured include differential gene expression, gene mutational spectra and protein–DNA/RNA ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0397-360

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84

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Contraceptives and HIV transmission (1997)

Duerr, Ann ; Warren, D. ; Smith, D. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 124-124

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — A recently reported study in macaques raised the possibility that use of contraceptives containing only progestins, such as Depo-Provera, may increase the likelihood of HIV transmission to women1. On considering a broader literature on the subject, we believe that it is ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-124a

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One too many tricks (1997)

Katz, Michael

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 125-125

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — Your news item “Choosing a polio vaccine is tricky business” (Nature Medicine 3, 7; 1997) contains a major error. In referring to the IPV, the article states: “the killed virus, injected intravenously…” The IPV is injected intramuscularly. An ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-125b

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86

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The best cytokine for the job (1997)

Levitsky, Hyam I.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 126-126

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — Dagmar Dilloo and colleagues report intriguing results describing the generation of potent anti-tumor immune responses against the A20 B cell lymphoma. Our recent experience using GM-CSF to prime anti-tumor immune responses contradict some of their results. Dilloo et al. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-126a

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87

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A retirement plan for research chimps (1997)

Nasto, Barbara

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 128-128

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Financial and ethical pressures weighing on the US government may give rise to a new kind of publicity funded retirement community: one that houses chimpanzees. Despite being infected with HIV and human hepatitis B virus, chimpanzees can live a projected 60 years in captivity. Current research ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-128

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88

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Contraceptives and HIV transmission (1997)

Marx, Preston A.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 124-124

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Marx replies — We agree with the above opinions regarding the information gleaned from the literature and from their studies on Depo-Provera. David Satcher (Director of the Centers for Disease Control and Prevention) stresses that any woman who wishes to control fertility and has found a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-124b

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89

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Just in TIME (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 135-135

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] After a year of hopeful, though often sensationalized, news in the fight against AIDS, the editors of TIME magazine have named a leading US AIDS researcher, David Ho, director of the Aaron Diamond AIDS Research Center in New York City, as their “Man of the Year” for 1996. Although it ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-135c

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90

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Unconventional T-cell activation by IL-15 in rheumatoid arthritis (1997)

Carson, Dennis A.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 148-149

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] RHEUMATOID ARTHRITIS CAUSES the normally thin joint lining to change into a disorganized granulation tissue, containing proliferating fibroblasts, activated macrophages, and aggregates of T and B lymphocytes enmeshed in a network of new blood vessels. The synovial macrophages release tumor necrosis ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-148

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91

Digitale Medien

Preterm birth, cerebral palsy and magnesium (1997)

Goldenberg, Robert L. ; Rouse, Dwight J.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 146-147

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] PRETERM BIRTH, WHICH occurs in 10 percent of all pregnancies, is a major problem in modern obstetrics, accounting for the majority of infant mortality and much long-term neurologic morbidity, including cerebral palsy and mental retardation. Adverse outcomes are concentrated in the most preterm ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-146

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92

Digitale Medien

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus (1997)

Borrow, Persephone ; Lewicki, Hanna ; Wei, Xiping ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 205-211

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the decline in viremia during primary HIV-1 infection, but definitive evidence that it is of importance in virus containment has been lacking. Here we show that in a patient whose early CTL response was focused ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-205

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93

Digitale Medien

Visualization of silicone gel in human breast tissue using new infrared imaging spectroscopy (1997)

Kidder, Linda H. ; Kalasinsky, Victor F. ; Luke, James L. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 235-237

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Between 1 and 2 million women in the United States have silicone breast implants. Complications include capsular contracture and calcification and possibly connective tissue diseases such as scleroderma and rheumatoid arthritis, a subject of some controversy1–7. In order to accurately assess ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-235

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94

Digitale Medien

Relatively low plasma leptin concentrations precede weight gain in Pima Indians (1997)

Ravussin, Eric ; Pratley, Richard E. ; Maffei, Margherita ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 238-240

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Leptin, the product of the ob gene1, is a hormone, produced by adipose cells, that inhibits food intake2–5 and increases energy expenditure2,3 in rodents. In humans, plasma leptin concentrations correlate closely with the size of the adipose tissue depot; however, there is considerable ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-238

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95

Digitale Medien

Impure Science: AIDS, Activism, and the Politics of Knowledge (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 242-243

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] by Steven Epstein University of California Press 1996 ISBN: 0-520-20233-3 $29.95 REVIEWED BY FINTAN R. STEELE Assistant Editor, News, Nature Medicine, Washington, DC 20045. My first day as a postdoctoral fellow at the National Institutes of Health (NIH) coincided with the 1990 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0297-242

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96

Digitale Medien

New biomedicine degree for European unversities (1997)

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1308-1308

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] European universities may soon be able to offer a new degree course in biomedicine if they follow the lead of the Karolinska Institute in Sweden and the Debrecen University Medical School in Hungary. In addition to teaching traditional biochemistry, physiology and pharmacology, the course ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1297-1308b

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97

Digitale Medien

Plasmodium falciparum malaria—sticky jams and PECAM pie (1997)

Berendt, Anthony R. ; Craig, Alister G.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1315-1316

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] BECAUSE PATHOGENS INITIATE and maintain infection by sticking to host tissues, identifying the molecular basis of this process has much to teach us. In Plasmodium faldparum malaria, erythrocytes containing mature forms of the parasite adhere to endothelial cells in deep vascular beds ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1297-1315

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98

Digitale Medien

More mayhem from molecular mimics (1997)

Steinman, Lawrence ; Oldstone, Michael B.A.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1321-1322

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] IN MULTIPLE SCLEROSIS (MS)—as in other autoimmune diseases—there has been feverish debate between those who believe that the disease is triggered by an environmental agent and those who champion a genetic basis1. But there is actually a reasonable reconciliation of these opposing views: ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1297-1321

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99

Digitale Medien

Act locally, think globally (1997)

Martuza, Robert L.

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1323-1323

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] PRIMARY MALIGNANT BRAIN tumors Comprise only a small proportion of the approximately 17,000 cancers that are diagnosed annually in the United States. Yet, two features of the most common and malignant brain tumor—glioblastoma—have made it the focus for studies into new anti-cancer ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1297-1323

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100

Digitale Medien

Rotavirus vaccines at the threshold (1997)

Glass, Roger I. ; Bresee, Joseph S. ; Parashar, Umesh ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 3 (1997), S. 1324-1325

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] IN 1998, ON the 25th anniversary of the discovery of rotavirus, the medical community is likely to be delivered an extraordinary gift in the form of the first vaccine that is proven to protect against rotavirus diarrhea, a severe childhood disease. The product is a live, oral, quadrivalent rhesus ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1297-1324

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