ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The Toxic and Sedative Bufadienolides of Kalanchoe daigremontiana HAMET et PERR.From the toxic Crassulacee Kalanchoe daigremontiana five biosynthetically related bufadienolides have been isolated and structurally elucidated by X-ray and 1H- and 13C-NMR spectroscopy. The compounds were identified as bersaldegenin 1,3,5-orthoacetate (2), bersaldegenin 1-acetate (4), bersaldegenin 3-acetate (3), 1β,3β,5,11α,14-pentahydroxy-12,19-dioxo-5β,14β-bufa-20,22-dienolide 1,3,5-orthoacetate ( = daigremontianin; 1), and 3β-acetoxy-1β,5,14-trihydroxy-5β,14β-bufa-20,22-dienolide ( = daigredorigenin-3-acetate, 5). According to the pharmacological investigations, the two orthoacetates 1 and 2 comprise the positive inotropic, sedative, and toxic activity of the plant.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19860690215
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