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  • Articles  (81)
  • Mice  (81)
  • 1985-1989
  • 1980-1984  (81)
  • 1981  (81)
  • Biology  (81)
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  • Articles  (81)
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Keywords
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  • 1985-1989
  • 1980-1984  (81)
Year
Journal
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  • 1
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    Sensory and motor functions of spinal cord substance P (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: Low doses of D-Pro2-D-Phe7-D-Trp9-substance P, as specific substance P antagonist, depressed the scratching and biting behaviors elicited by intrathecal injections of substance P, and cutaneous application of algesic substances. Higher antagonist doses caused hindlimb paralysis. This suggests that substance P is a neurotransmitter for primary nociceptor afferents and may also have an important function in motor control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piercey, M F -- Schroeder, L A -- Folkers, K -- Xu, J C -- Horig, J -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6171882" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Capsaicin/pharmacology ; Mice ; Motor Activity/drug effects ; Pain/*physiopathology ; Receptors, Cell Surface/drug effects ; Receptors, Neurokinin-1 ; Receptors, Neurotransmitter/drug effects ; Skin/drug effects ; Spinal Cord/*physiology ; Substance P/analogs & derivatives/antagonists & ; inhibitors/pharmacology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Hydrogen isotope ratios of mouse tissues are influenced by a variety of factors other than diet (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeNiro, M J -- Epstein, S -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1374-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Deuterium/*metabolism ; *Diet ; Hydrogen/*metabolism ; Mice ; Water/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Taurine: possible role in osmotic regulation of mammalian heart (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: It is well established that taurine plays an important role in the maintenance of intracellular osmolal concentration in marine invertebrates, teleosts, and amphibians. In fresh water, concentrations of taurine in body tissues decrease; in salt water, they increase. In this study with mice we found that during adaptation of these mammals to chronic hypernatremia, the taurine content of the heart increased; concentrations of other amino acids were unchanged or were decreased. Welty and his associated have shown that acute hyponatremia lowered the taurine concentration of rat heart. In concert, these data suggest that taurine also may serve as an osmotic agent in mammalian heart.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thurston, J H -- Hauhart, R E -- Naccarato, E F -- NB 06163/NB/NB NIH HHS/ -- NS 15660/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1373-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313699" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/*physiology ; Animals ; Heart/*physiology ; Mice ; Taurine/*physiology ; Water-Electrolyte Balance
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Integration and stable germ line transmission of genes injected into mouse pronuclei (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: Genetic material has been successfully transferred into the genomes of newborn mice by injection of that material into pronuclei of fertilized eggs. Initial results indicated two patterns of processing the injected DNA: one in which the material was not integrated into the host genome, and another in which the injected genes became associated with high molecular weight DNA. These patterns are maintained through further development to adulthood. The evidence presented indicates the covalent association of injected DNA with host sequences, and transmission of such linked sequences in a Mendelian distribution to two succeeding generations of progeny.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gordon, J W -- Ruddle, F H -- GMO7959-01/GM/NIGMS NIH HHS/ -- GMO9966/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1244-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272397" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/*metabolism ; Crosses, Genetic ; DNA Restriction Enzymes ; DNA, Recombinant/*metabolism ; Embryo, Mammalian/*physiology ; Female ; *Genes ; Genetic Linkage ; Herpesviridae/enzymology ; Male ; Mice ; Nucleic Acid Hybridization ; Ovum/*physiology ; *Plasmids ; Pregnancy ; Sex Ratio ; Simian virus 40/enzymology ; Thymidine Kinase/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Germplasm conservation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russell, E S -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1074, 1076.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6946561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Disease Models, Animal ; Dogs ; *Genetic Engineering ; *Genetics, Medical ; Humans ; Mice ; Mutation ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Renin and angiotensin: the complete system within the neuroblastoma x glioma cell (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: Cells of the homogeneous hybrid line neuroblastoma x glioma (NG108-15) have many neuronal properties. Immunocytochemical tests show that they contain both immunoreactive renin and angiotensin; direct radioimmunoassays show that they are positive for renin, angiotensin I, and angiotensin II; enzymatic assays show that they contain angiotensinogen and converting enzyme as well. The renin appears to be present in an enzymatically inactive form that can be activated by trypsin and then blocked by antiserum to purified mouse submaxillary renin. Renin concentration and activity are increased by enhancing cellular differentiation with dibutyryl cyclic adenosine monophosphate or by serum withdrawal. These findings demonstrate a complete renin-angiotensin system within these neuron-like cells, and suggest that activation of intracellular renin could generate angiotensin II.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishman, M C -- Zimmerman, E A -- Slater, E E -- HL-21247/HL/NHLBI NIH HHS/ -- HL-24105/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272392" target="_blank"〉PubMed〈/a〉
    Keywords: Angiotensin I/*analysis ; Angiotensin II/*analysis ; Angiotensins/*analysis ; Animals ; Cell Line ; Cricetinae ; Glioma/*metabolism ; Hybrid Cells/*metabolism ; Mice ; Neuroblastoma/*metabolism ; Peptidyl-Dipeptidase A/metabolism ; Radioimmunoassay ; Rats ; Renin/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Fetal alcohol syndrome: embryogenesis in a mouse model (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: When two small doses of ethanol were administered to pregnant mice during the gastrulation stage of embryogenesis, the embryos developed craniofacial malformations closely resembling those seen in the human fetal alcohol syndrome. Striking histological changes appeared in the developing brain (neuroectoderm) within 24 hours of exposure. Decreased development of the neural plate and its derivatives apparently accounts for the craniofacial malformations. The critical exposure period is equivalent to the third week in human pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sulik, K K -- Johnston, M C -- Webb, M A -- DE 02668/DE/NIDCR NIH HHS/ -- DE 05906/DE/NIDCR NIH HHS/ -- RR 05333/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):936-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795717" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Child ; Disease Models, Animal ; Embryo, Mammalian/*drug effects/ultrastructure ; Ethanol/*pharmacology ; Eye Abnormalities ; Female ; Fetal Alcohol Spectrum Disorders/*physiopathology ; Humans ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron, Scanning ; Pregnancy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Melatonin: identification of sites of antigonadal action in mouse brain (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-13
    Description: Long-term implants releasing a small quantity of melatonin (45 nanograms per day) were used to determine the brain sites of the hormone's antigonadal action in a photoperiodic species, the white-footed mouse (Peromyscus leucopus). Implants in the medial preoptic and supra- and retrochiasmatic areas elicited completed gonadal regression after 7 weeks. Implants in other brain regions had little effect on the animals' reproductive state.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glass, J D -- Lynch, G R -- NS-15503/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):821-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Genitalia, Female/drug effects/*pathology ; Hypothalamus/*drug effects ; Light ; Melatonin/*pharmacology ; Mice ; Periodicity ; Preoptic Area/drug effects ; Supraoptic Nucleus/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Individual hippocampal mossy fiber distribution in mice correlates with two-way avoidance performance (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-13
    Description: Mice systematically bred for randomization of their genotype show large individual differences when performing a two-way avoidance task (shuttle-box learning). Their behavioral scores correlate strongly (r = -0.80, P less than .01) with the number of mossy fibers synapsing on basal dendrites of hippocampal pyramidal neurons, poor avoiders having relatively more such terminals. This confirms previous findings showing that rat and mouse strains known for genetically dependent poor avoidance learning have extended intra- and infrapyramidal mossy fiber projections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwegler, H -- Lipp, H P -- Van der Loos, H -- Buselmaier, W -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):817-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292015" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/*physiology ; Female ; Hippocampus/*cytology/physiology ; Male ; Mice ; Neural Pathways/physiology ; Pyramidal Tracts/cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Hemin lyses malaria parasites (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-06
    Description: Malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin IX chloride (hemin) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin. This effect of hemin may explain the protection against malaria provided by thalassemia and other conditions causing intracellular denaturation of hemoglobin. The toxicity of the chloroquine-hemin complex may explain the selective antimalarial action of chloroquine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Orjih, A U -- Banyal, H S -- Chevli, R -- Fitch, C D -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):667-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7027441" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chloroquine/*pharmacology ; Drug Interactions ; Drug Resistance ; Heme/*analogs & derivatives ; Hemin/*pharmacology ; Mice ; Plasmodium berghei/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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