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  • Species Specificity  (23)
  • Disease Models, Animal  (20)
  • American Association for the Advancement of Science (AAAS)  (43)
  • American Meteorological Society (AMS)
  • Annual Reviews
  • 1990-1994
  • 1980-1984  (43)
  • 1981  (43)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (43)
  • American Meteorological Society (AMS)
  • Annual Reviews
Years
  • 1990-1994
  • 1980-1984  (43)
Year
  • 1
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    Similar amino acid sequences: chance or common ancestry? (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-09
    Description: The systemic comparison of every newly determined amino acid sequence with all other known sequences may allow a complete reconstruction of the evolutionary events leading to contemporary proteins. But sometimes the surviving similarities are so vague that even computer-based sequence comparisons procedures are unable to validate relationships. In other cases similar sequences may appear in totally alien proteins as a result of mere chance or, occasionally, by the convergent evolution of sequences with special properties.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doolittle, R F -- New York, N.Y. -- Science. 1981 Oct 9;214(4517):149-59.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280687" target="_blank"〉PubMed〈/a〉
    Keywords: *Amino Acid Sequence ; Animals ; *Biological Evolution ; Carrier Proteins/genetics ; Humans ; Proteins/classification/*genetics ; RNA Splicing ; RNA, Messenger/genetics ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Phenytoin-induced teratogenesis: a mouse model (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: Malformations associated with the fetal hydantoin syndrome have been reproduced in a mouse model. The occurrence of these defects was correlated with maternal serum concentrations, but not with maternal or fetal genotype or the presence of a seizure disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finnell, R H -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):483-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455686" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Epilepsy/drug therapy ; Female ; Mice ; Mice, Neurologic Mutants/physiology ; Phenytoin/*adverse effects ; *Teratogens
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    The complement system of the nurse shark: hemolytic and comparative characteristics (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: The complement system of the nurse shark was investigated. Six functionally pure components were isolated from a single serum sample. Sequential reactions of the components with sensitized sheep erythrocytes resulted in membrane lesions indistinguishable from the "holes" caused by guinea pig complement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jensen, J A -- Festa, E -- Smith, D S -- Cayer, M -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):566-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291995" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Complement System Proteins/*physiology ; Erythrocyte Membrane/immunology ; Hemolysis ; Sharks/*immunology ; Sheep ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Diameter of the cell-to-cell junctional membrane channels as probed with neutral molecules (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules-neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides. From the molecular dimensions of the largest permeants and smallest impermeants the permeation-limiting channel diameter was obtained: 16 to 20 angstroms for the mammalian cells and 20 to 30 angstroms for the insect cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwarzmann, G -- Wiegandt, H -- Rose, B -- Zimmerman, A -- Ben-Haim, D -- Loewenstein, W R -- CA 14464/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244653" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chironomidae ; Fluorescent Dyes ; Glycopeptides/*metabolism ; Intercellular Junctions/*ultrastructure ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Oligosaccharides/*metabolism ; Protein Conformation ; Salivary Glands/*ultrastructure ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Elastic arteries in invertebrates: mechanics of the octopus aorta (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: The aorta of the octopus, Octopus dofleini, is a highly distensible, elastic tube. The circumferential elastic modulus increases with inflation in the physiological range from abut 10(4) to 10(5) newtons per square meter. Rubber-like fibers have been isolated, apparently for the first time, from the aorta of an invertebrate. These fibers have an elastic modulus, like elastin, of about 4 x 10(5) newtons per square meter and are present in sufficient quantity to account for the elastic properties of the intact vessel under physiological conditions. Thus the circulatory system of an invertebrate animal provides an "elastic reservoir" (much like that of the vertebrate system), which increases the efficiency of the circulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shadwick, R E -- Gosline, J M -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):759-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256277" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta/anatomy & histology/*physiology ; Elasticity ; Octopodiformes/*physiology ; Proteins/physiology ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Functional restoration of vision in the cat after long-term monocular deprivation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: Recovery of visual acuity was studied in six long-term monocularly deprived cats after removal of the nondeprived eye or reverse lid suture. Although both manipulations improved visual acuity, removal of the nondeprived eye was associated with more rapid recovery and higher find acuity than in reverse suture. These results are in agreement with the known electrophysiological effects of these recovery conditions and are also similar to the effects of reverse occlusion or loss of the nonamblyopic eye in human amblyopes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, D C -- EYO 7005/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1137-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268422" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Amblyopia/physiopathology ; Animals ; Cats ; Disease Models, Animal ; Form Perception/physiology ; Visual Acuity ; Visual Cortex/growth & development/*physiology ; Visual Perception/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 7
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    Studies in histocompatibility (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snell, G D -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):172-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017931" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Antigens, Neoplasm/genetics ; Antigens, Viral/genetics ; Antigens, Viral, Tumor ; Female ; Genetic Linkage ; Genotype ; H-2 Antigens/genetics ; Heterozygote ; *Major Histocompatibility Complex ; Male ; Mice ; Mice, Inbred Strains ; Neoplasms, Experimental/genetics/*immunology ; Pedigree ; Rats ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Carcinogen testing: current problems and new approaches (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-23
    Description: The classic procedures for testing potential carcinogens in animals have basically not changed in the past 50 years. Considerable knowledge of the mechanisms of carcinogenesis has accrued in the last 20 years, particularly concepts on the metabolic activation of chemicals to reactive electrophilic compounds that can interact with nucleophilic including DNA. These developments, in turn, have yielded a framework for integrating into carcinogen testing the determination of genetic effects of chemicals. A systematic decision point approach to carcinogen testing has been developed which entails a sequential decision-making process as specific tests are performed and evaluated prior to initiation of higher order, more complex tests. Compared to conventional bioassays in rodents, this approach provides knowledge based on mechanisms of carcinogenesis, yields a substantial amount of data at minimal cost, and forms a solid base for eventual heath risk assessment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weisburger, J H -- Williams, G M -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):401-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291981" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; *Carcinogens ; Disease Models, Animal ; *Drug Evaluation, Preclinical ; Mutagenicity Tests ; Mutagens ; Neoplasms, Experimental/*etiology ; Research Design
    Print ISSN: 0036-8075
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  • 9
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    Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain of feline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each onc gene counterpart has a single genetic locus, which probably contains non-onc intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong-Staal, F -- Dalla-Favera, R -- Franchini, G -- Gelmann, E P -- Gallo, R C -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):226-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Cell Transformation, Viral ; *Cloning, Molecular ; DNA/*genetics ; DNA, Viral/*genetics ; *Genes ; Humans ; Nucleic Acid Hybridization ; Retroviridae/*genetics ; Sarcoma Virus, Woolly Monkey/genetics ; Sarcoma Viruses, Murine/genetics ; Species Specificity
    Print ISSN: 0036-8075
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  • 10
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    Drug discrimination learning in lead-exposed rats (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: Lead acetate (0.02 or 0.5 percent) was administered to dams throughout the lactation period with half of the litters continuing on lead after weaning. Drug thresholds for d-amphetamine were determined by using the drug-discrimination learning paradigm. All the offspring that had been exposed to lead were less sensitive to the stimulus properties of d-amphetamine irrespective of whether or not they had continued on lead after weaning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zenick, H -- Goldsmith, M -- New York, N.Y. -- Science. 1981 May 1;212(4494):569-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209554" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Dextroamphetamine/*pharmacology ; Discrimination Learning/*physiology ; Disease Models, Animal ; Female ; Fetus/drug effects ; Lead Poisoning/*physiopathology ; Male ; Pregnancy ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Tyrosine increases blood pressure in hypotensive rats (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: Administration of tyrosine, the amino acid precursor of catecholamines, increased blood pressure 38 to 49 percent in rats made acutely hypotensive by hemorrhage; other large neutral amino acids were ineffective. Tyrosine's effect was abolished by adrenalectomy, suggesting that, in hypotensive animals, it acts by accelerating the peripheral synthesis and release of catecholamines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Conlay, L A -- Maher, T J -- Wurtman, R J -- AM-14228/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 May 1;212(4494):559-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209553" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Blood Pressure/*drug effects ; Catecholamines/metabolism ; Disease Models, Animal ; Hypotension/*drug therapy/physiopathology ; Male ; Rats ; Tyrosine/*pharmacology/therapeutic use
    Print ISSN: 0036-8075
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  • 12
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    Immunology of archaebacteria that produce methane gas (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: The antigenic map of 17 methanogenic bacteria representing the entire range of available species was determined by multiple assay with antibody probes. Four major clusters of antigenically related strains coincide with the females proposed on the basis of 16S ribosomal RNA analysis. Immunological mapping uncovered relationships not yet shown by other methods and allowed identification and classification of two new bacterial isolates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Conway de Macario, E -- Wolin, M J -- Macario, A J -- NIAID AI-12461/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):74-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6792708" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Bacterial/*analysis ; Archaea/classification/*immunology ; Bacteria/*immunology ; Euryarchaeota/classification/*immunology ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 13
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    Behavioral effects of lead and Toxocara canis in mice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: Adult mice were administered the common parasite Toxocara canis or lead or both. The parasite clearly altered mouse performance on tests of exploration, activity, learning, and motor coordination; behavioral effects in mice receiving lead alone were less general. Consequence of Toxocara administration appeared attenuated in animals receiving both agents. Parasite larvae were found in the central nervous system in all infected mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dolinsky, Z S -- Burright, R G -- Donovick, P J -- Glickman, L T -- Babish, J -- Summers, B -- Cypess, R H -- 08-K4AI00301A-03/AI/NIAID NIH HHS/ -- 08R1AI1478A-03/AI/NIAID NIH HHS/ -- 5S07RR0749-04/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1142-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268424" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascariasis/*complications ; Behavior, Animal/*physiology ; Brain/parasitology ; Disease Models, Animal ; Lead Poisoning/*complications/physiopathology ; Male ; Mice ; Toxocariasis/*complications/physiopathology
    Print ISSN: 0036-8075
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  • 14
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    Substance P activity in the bullfrog retina: localization and identification in several vertebrate species (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: Immunoreactive substance P is present in the bullfrog retina, possibly in two types of stratified amacrine cells, with their somas in the inner nuclear layer and their neuronal processes entering the inner plexiform layer and ramifying in sublayers 3 or 4 (or both). Occasionally, polygonal somas positive for substance P were found in the ganglion cell layer. Approximately 75 percent of the cell bodies positive for substance P and 65 percent of the radioimmunoassayable substance P were found in the superior half of the frog retina. On the basis of high-performance liquid chromatography, the immunoreactive substance P in the neural retina of the rat, monkey, or chick is similar to synthetic substance P, whereas this is not true of the immunoreactive substance P in the bullfrog or carp retina.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eskay, R L -- Furness, J F -- Long, R T -- New York, N.Y. -- Science. 1981 May 29;212(4498):1049-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6165081" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chickens ; Fluorescent Antibody Technique ; Macaca ; Rana catesbeiana ; Rats ; Retina/analysis/*cytology ; Species Specificity ; Substance P/*analysis
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  • 15
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    Opiate antagonist improves neurologic recovery after spinal injury (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: The opiate antagonist naloxone has been used to treat cats subjected to cervical spinal trauma. In contrast to saline-treated controls, naloxone treatment significantly improved the hypotension observed after cervical spinal injury. More critically, naloxone therapy significantly improved neurologic recovery. These findings implicate endorphins in the pathophysiology of spinal cord injury and indicate that narcotic antagonists may have a therapeutic role in this condition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faden, A I -- Jacobs, T P -- Holaday, J W -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):493-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455690" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/*drug effects ; Cats ; Disease Models, Animal ; Endorphins/antagonists & inhibitors ; Naloxone/pharmacology/*therapeutic use ; Spinal Cord/blood supply ; Spinal Cord Injuries/*drug therapy/physiopathology
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  • 16
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    Phototherapy-induced hypocalcemia in newborn rats: prevention by melatonin (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-13
    Description: When young rats are exposed to white fluorescent light the concentration of calcium in their serum decreases. This effect is prevented by shielding the occiput, by inhibiting corticosterone synthesis, and by exogenous melatonin. Furthermore, the expected hypocalcemic response to cortisol injection is prevented by melatonin. Light-induced hypocalcemia may result from increased calcium uptake by bone when the blocking effect of melatonin decreases after pineal inhibition by transcranial illumination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hakanson, D O -- Bergstrom, W H -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):807-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6895262" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*radiation effects ; Disease Models, Animal ; Female ; Humans ; Hydrocortisone/antagonists & inhibitors ; Hypocalcemia/etiology/*prevention & control ; Infant, Newborn ; Jaundice, Neonatal/therapy ; Light ; Male ; Melatonin/*pharmacology ; Phototherapy/adverse effects ; Rats ; Spectrum Analysis ; Time Factors
    Print ISSN: 0036-8075
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  • 17
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    Estradiol and progesterone profiles indicate a lack of endocrine recognition of pregnancy in the opossum (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: Concentrations of estradiol and progesterone in blood collected during the 12.5-day gestation period of the Virginia opossum were not significantly different from those during equivalent days of the estrous cycle. Progesterone was correlated with an index of corpora luteral mass. Ratio of estradiol to progesterone were highest 3 to 4 days before estrus and on the day of parturition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harder, J D -- Fleming, M W -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1400-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233228" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Corpus Luteum/physiology ; Estradiol/*blood ; Estrus ; Female ; Opossums/*physiology ; Pregnancy ; *Pregnancy, Animal ; Progesterone/*blood ; Species Specificity
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  • 18
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    Rapid induction of cellular strain specificity by newly acquired cytoplasmic components in amoebas (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorch, I J -- Jeon, K W -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):949-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466367" target="_blank"〉PubMed〈/a〉
    Keywords: Amoeba/genetics/microbiology/*physiology ; Animals ; Cell Nucleus/physiology ; Cytoplasm/physiology ; Species Specificity ; *Symbiosis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Assessment of pharmacological treatment of myocardial infarction by phosphorus-31 NMR with surface coils (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-09
    Description: Phosphorus-31 nuclear magnetic resonance (NMR) measurements with small surface coils have been used to observe phosphorus metabolism of perfused hearts within localized regions. The method allows for direct, noninvasive, sequential assessment of the altered regional metabolism resulting from myocardial infarction and its response to drug treatment, which cannot be observed by conventional techniques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nunnally, R L -- Bottomley, P A -- GM 17172/GM/NIGMS NIH HHS/ -- HL 17655-06/HL/NHLBI NIH HHS/ -- HL 22080/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 9;211(4478):177-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chlorpromazine/therapeutic use ; Coronary Circulation/drug effects ; Disease Models, Animal ; Magnetic Resonance Spectroscopy/*methods ; Myocardial Infarction/*diagnosis/drug therapy/metabolism ; Phosphorus/*metabolism ; Phosphorus Isotopes ; Rabbits ; Verapamil/therapeutic use
    Print ISSN: 0036-8075
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  • 20
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    Hyperkeratosis induced by sunlight degradation products of the major polybrominated biphenyl in Firemaster (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-21
    Description: Sunlight photodegradation of 2,2', 4,4', 5,5' -hexabromobiphenyl, the major component of Firemaster, gave a mixture that produces severe hyperkeratosis of the rabbit ear. This component in its pure state does not cause hyperkeratosis. One or more of the four major photolysis products must be responsible for this activity. A similar photodegradation pattern was observed for 2,2', 3,4,4', 5,5' -heptabromobiphenyl, the second largest component of Firemaster.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patterson, D G -- Hill, R H -- Needham, L L -- Orti, D L -- Kimbrough, R D -- Liddle, J A -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):901-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6266016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biphenyl Compounds/radiation effects ; Chemical Industry ; Disease Models, Animal ; Environmental Exposure ; Keratosis/*chemically induced ; Michigan ; Photochemistry ; *Polybrominated Biphenyls/radiation effects ; Rabbits ; Sunlight
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    Psychoneuroendocrine influences on immunocompetence and neoplasia (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: Emotional, psychosocial, or anxiety-stimulated stress produces increased plasma concentrations of adrenal corticoids and other hormones though well-known neuroendocrine pathways. A direct consequence of these increased corticoid concentrations is injury to elements of the immunological apparatus, which may leve the subject vulnerable to the action of latent oncogenic viruses, newly transformed cancer cells, or other incipient pathological processes that are normally held in check by an intact immunological apparatus. This article describes studies that examine the adverse effects of increased plasma concentrations of adrenal corticoids on the thymus and thymus-dependent T cells, inasmuch as these elements constitute a major defense system against various neoplastic processes and other pathologies. The studies demonstrate that anxiety-stress can be quantitatively induced and the consequences measured through specific biochemical and cellular parameters, providing that authentic quiescent baselines of these conditions are obtained in the experimental animals by the use of low-stress protective housing and handling techniques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, V -- CA 12188/CA/NCI NIH HHS/ -- CA 16308/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1100-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233204" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Corticosterone/blood ; Female ; Handling (Psychology) ; Humans ; *Immunocompetence ; Leukocytes/physiology ; Mice ; Mice, Inbred Strains ; Neoplasms/*etiology/physiopathology/psychology ; Neoplasms, Experimental/*physiopathology ; Species Specificity ; Stress, Physiological/*complications ; Stress, Psychological/*complications ; Tumor Virus Infections/physiopathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    Hydra mesoglea: a model for investigating epithelial cell--basement membrane interactions (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-16
    Description: Isolated hydra mesoglea served as a suitable substrate for the attachment and spreading of hydra cells in vitro, irrespective of the species tested. Hydra cells did not attach and spread on substrates typically used for culturing mammalian cells. Mammalian and Drosophila cells attached and spread on plastic culture dishes but not on isolated mesoglea. Xenopus epithelial cells spread on both plastic and mesoglea. Because of the similarities of hydra mesoglea to vertebrate basement membranes, suggestions are offered for using mesoglea to study the interactions of epithelial cells with their basement membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Day, R M -- Lenhoff, H M -- New York, N.Y. -- Science. 1981 Jan 16;211(4479):291-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444468" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basement Membrane/physiology ; Biological Evolution ; Cell Adhesion ; Cell Line ; Epithelial Cells ; Extracellular Space/physiology ; Hydra/*cytology ; Species Specificity
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  • 23
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    Lophotoxin: a novel neuromuscular toxin from Pacific sea whips of the genus Lophogorgia (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: A new neuromuscular toxin, lophotoxin, has been isolated from several pacific gorgonians of the genus Lophogorgia. The structure of lophotoxin was deduced by combined spectrochemical methods, and belongs to the well-known cembrene class of diterpenoid molecules. Lophotoxin contains furanoaldehyde and alpha, beta-epoxy-gamma-lactone functional groups, in sharp contrast to the cationic ammonium functional groups of the established neurotoxins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fenical, W -- Okuda, R K -- Bandurraga, M M -- Culver, P -- Jacobs, R S -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1512-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6112796" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cnidaria/*analysis ; Cnidarian Venoms/*isolation & purification/pharmacology ; Diterpenes/*isolation & purification/pharmacology/toxicity ; Electric Stimulation ; Mice ; Muscle Contraction/drug effects ; Muscles/innervation ; Neuromuscular Junction/drug effects/physiology ; Species Specificity ; *Terpenes
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  • 24
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    Giant synaptic potential hypothesis for epileptiform activity (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-01-16
    Description: According to one hypothesis, the paroxysmal depolarizing shift observed in the penicillin model of epilepsy results from a giant excitatory postsynaptic potential. This hypothesis has recently been questioned, primarily because it has never been subjected to rigorous experimental examination. Four quantitative predictions were derived from this hypothesis and tested in CA3 pyramidal neurons of the hippocampus. The four critical predictions concern the behavior of the paroxysmal depolarizing shift under current- and voltage-clamp conditions as a function of membrane potential. The experiments confirmed all four predictions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnston, D -- Brown, T H -- NS11535/NS/NINDS NIH HHS/ -- NS15772/NS/NINDS NIH HHS/ -- RR-05471-17/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 16;211(4479):294-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444469" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Disease Models, Animal ; Electric Conductivity ; Epilepsy/*physiopathology ; Guinea Pigs ; Hippocampus/*physiopathology ; In Vitro Techniques ; Membrane Potentials ; Penicillin G ; Synaptic Membranes/physiology
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  • 25
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    Rapid correction of hyponatremia causes demyelination: relation to central pontine myelinolysis (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-06
    Description: The human demyelinative disorder central pontine myelinolysis may be an iatrogenic disease caused by a rapid rise in serum sodium, usually when hyponatremia is corrected. Rats treated with hypertonic saline after 3 days of vasopressin-induced hyponatremia had demyelinative lesions in the corpus striatum, lateral hemispheric white matter, cerebral cortex, hippocampal fimbria, anterior commissure, thalamus, brainstem tegmentum, and cerebellum. Thus, rapid correction of hyponatremia can lead to demyelinative lesions and may be the cause of central pontine myelinolysis in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kleinschmidt-DeMasters, B K -- Norenberg, M D -- New York, N.Y. -- Science. 1981 Mar 6;211(4486):1068-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466381" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood-Brain Barrier ; Brain Diseases/*etiology ; Demyelinating Diseases/*etiology/pathology ; Disease Models, Animal ; Hyponatremia/*complications ; Male ; Pons/*pathology ; Rats
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  • 26
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    Carcinogens and regulation (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lappe, M -- Hooper, K -- Blake, E -- Pfund, N -- Gardner, E -- Rosenberg, J -- New York, N.Y. -- Science. 1981 Jan 23;211(4480):332-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221543" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; *Carcinogens ; Dose-Response Relationship, Drug ; Humans ; Species Specificity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 27
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    Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Radioactive nitrogen-13 from nitrite (NO2-) or nitrate (NO3-) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered. Nitrogen-13 from both anions was distributed uniformly between plasma and blood cells. We found rapid in vivo oxidation of NO2- to NO3- at concentrations of 2 to 3 nanomoles per liter in blood. Over 50 percent oxidation within 10 minutes accounted for the similar nitrogen-13 distributions from both parent ions. The oxidation rates were animal species-dependent. No reduction of 13NO3- to 13NO2- was observed. A mechanistic hypothesis invoking oxidation of 13NO2- by a catalase-hydrogen peroxide complex accounts for the results. These results imply a concentration dependence for the in vivo fate of NO2- or nitrogen dioxide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parks, N J -- Krohn, K J -- Mathis, C A -- Chasko, J H -- Geiger, K R -- Gregor, M E -- Peek, N F -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):58-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209517" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatography, High Pressure Liquid ; Injections, Intravenous ; Mice ; Mice, Inbred BALB C ; Nitrates/administration & dosage/*metabolism ; Nitrites/administration & dosage/*metabolism ; Nitrogen Isotopes ; Oxidation-Reduction ; Rabbits ; Species Specificity ; Tissue Distribution ; Trachea
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  • 28
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    Structural correlates of seizure behavior in the mongolian gerbil (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-08-21
    Description: Hippocampi of seizure-sensitive and seizure-resistant Mongolian gerbils were examined in search of structural correlates of seizure behavior. In animals with well-established seizure histories, differences were found in both presynaptic and postsynaptic structures. Seizing animals had less dense dendritic spines, a greater proportion of mossy tuft area devoted to presynaptic vesicles, and a smaller proportion devoted to spines. The possible relationship of these findings to epilepsy is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paul, L A -- Fried, I -- Watanabe, K -- Forsythe, A B -- Scheibel, A B -- 5-507-RR05756-06/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):924-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256289" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Gerbillinae/*anatomy & histology/physiology ; Hippocampus/*anatomy & histology/ultrastructure ; Microscopy, Electron ; Seizures/pathology/*physiopathology
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  • 29
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    Neural gonadal steroid actions (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-20
    Description: Neurons sensitive to gonadal steroids are located strategically within neural circuits that mediate behaviors broadly related to the reproductive process. Some neuronal events and properties are regulated by these hormones. Variability in the occurrence and distribution of particular neural hormonal sensitivities across species may be related to variations in the hormonal requirements for sexual differentiation and for activation of reproductive behaviors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McEwen, B S -- NS07080/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1303-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259728" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/metabolism/physiology ; Animals ; Brain/enzymology/metabolism ; Estrogens/metabolism/physiology ; Female ; Gonadal Steroid Hormones/*physiology ; Gonads/secretion ; Humans ; Male ; Neurons/metabolism ; Progestins/metabolism ; Rats ; Receptors, Cell Surface/metabolism ; Receptors, Progesterone/metabolism ; *Sex Differentiation ; *Sexual Behavior ; Species Specificity ; Vertebrates/physiology
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  • 30
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    Species-typical behavior of hamsters deprived from birth of the neocortex (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-07-24
    Description: Hamsters deprived from birth of the neocortex developed normally and displayed the usual hamster-typical behavioral patterns. With the additional concurrent destruction of midline limbic convolutions (cingulate and underlying dorsal hippocampal), there were deficits in maternal behavior and a lack of development of play behavior. These findings demonstrate in a rodent (i) that the striatal complex and limbic system, along with the remaining neuraxis, are sufficient for giving expression to a wide range of unlearned forms of species-typical behavior and (ii) that midline limbic structures are required for the expression of play behavior and the integrated performance of maternal behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, M R -- MacLean, P D -- Hamilton, S C -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244642" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; *Behavior, Animal ; Cerebral Cortex/*physiology ; Cricetinae ; Mesocricetus ; Species Specificity
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  • 31
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    Spontaneous diabetes in rats: destruction of islets is prevented by immunological tolerance (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-09-18
    Description: Spontaneous diabetes occurring in "BB" rats (derived from a colony of outbred Wistar rats) is the result of destruction of pancreatic islets by infiltrating mononuclear cells (insulitis) and may be a disease very similar to human juvenile onset diabetes. Both diseases probably have an autoimmune etiology. Evidence is presented that islets transplanted to diabetic BB rats are destroyed by the original disease process. Inoculation of bone marrow from normal (nondiabetes-susceptible) rat donors into neonatal BB recipients usually prevented the development of hyperglycemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Naji, A -- Silvers, W K -- Bellgrau, D -- Barker, C F -- AM19525/AM/NIADDK NIH HHS/ -- AM26007/AM/NIADDK NIH HHS/ -- CA18640/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 18;213(4514):1390-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6791286" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoimmune Diseases/*immunology ; Bone Marrow Transplantation ; Diabetes Mellitus, Experimental/*immunology ; Disease Models, Animal ; Graft Rejection ; Immune Tolerance ; Islets of Langerhans/*immunology ; Islets of Langerhans Transplantation ; Rats
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  • 32
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    Cross-contamination of cells in culture (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-04-24
    Description: Lists are presented of references to all known publications describing cell properties that serve to characterize (i) known strains of HeLa and purported human cell lines indicated as HeLa contaminants, (ii) strains of human cell lines contaminated with human but non-HeLa cells, and (iii) strains of cells contaminated by cells from one or more other species. Frequencies of cell cross-contaminations are cited and references are presented to relatively simple techniques that could serve to detect such contamination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson-Rees, W A -- Daniels, D W -- Flandermeyer, R R -- YO1 CP8-0500/CP/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):446-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6451928" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Line ; Cells, Cultured/enzymology/*physiology ; Glucosephosphate Dehydrogenase/analysis ; Humans ; Isoenzymes/analysis ; Karyotyping ; Phosphoglucomutase/analysis ; Species Specificity
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  • 33
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    Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-30
    Description: Over the course of 20 weeks, Sprague-Dawley rats developed intestinal tumors in response to an intraperitoneal injection of the acetate derivative of dimethylnitrosamine. The same agent did not induce tumors in Lobund-Wistar rats. The number of tumors was significantly smaller in rats given drinking water containing indomethacin (beginning 14 days after the injections) than in control rats given drug-free water.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollard, M -- Luckert, P H -- CA 00295/CA/NCI NIH HHS/ -- CA 15957/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):558-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dimethylnitrosamine/*analogs & derivatives/antagonists & inhibitors ; Indomethacin/*pharmacology ; Intestinal Neoplasms/*chemically induced ; Male ; Neoplasms, Experimental/chemically induced ; Rats ; Rats, Inbred Strains ; Species Specificity
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  • 34
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    Tyrosine administration decreases vulnerability to ventricular fibrillation in the normal canine heart (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-02-13
    Description: Intravenous infusion of tyrosine (1, 2, or 4 milligrams per kilogram) for 20 to 30 minutes caused dose-dependent increases in the ventricular fibrillation threshold in normal dogs. Administration of valine, a neutral amino acid that competes with tyrosine for uptake at the blood-brain barrier, in a dose equimolar to the most effective dose of tyrosine, slightly decreased the ventricular fibrillation threshold when given alone and significantly blocked elevation of the ventricular fibrillation threshold after tyrosine infusion. Hence, tyrosine, presumably acting in the central nervous system, can protect against certain ventricular arrhythmias.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scott, N A -- DeSilva, R A -- Lown, B -- Wurtman, R J -- 21384-08/PHS HHS/ -- AM-14228/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Feb 13;211(4483):727-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455710" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood-Brain Barrier ; Catecholamines/metabolism ; Disease Models, Animal ; Dogs ; Tyrosine/antagonists & inhibitors/metabolism/*therapeutic use ; Valine/pharmacology ; Ventricular Fibrillation/*prevention & control
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  • 35
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    Species restriction of a monoclonal antibody reacting with residues 130 to 137 in encephalitogenic myelin basic protein (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: A monoclonal antibody (immunoglobulin G1) has been produced that reacts against myelin basic protein present in or extracted from the brains of many mammals-with certain important exceptions. Because of known species differences in amino acid sequences of basic protein and of certain peptide fragments, the binding site for this particular antibody appeared likely to include residues 130 to 137. Confirmation of this hypothesis was obtained by amino acid composition of the major immunoreactive peptides produced by thermolysin digestion of human basic protein and isolated by high-performance liquid chromatography.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sires, L R -- Hruby, S -- Alvord, E C Jr -- Hellstrom, I -- Hellstrom, K E -- Kies, M W -- Martemspm, R -- Deibler, G E -- Beckman, E D -- Casnellie, J E -- CA-19148/CA/NCI NIH HHS/ -- CA-25558/CA/NCI NIH HHS/ -- CA-26584/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):87-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169147" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Monoclonal ; Cattle ; Chickens ; Epitopes ; Guinea Pigs ; Humans ; Macaca ; Myelin Basic Protein/*immunology ; Peptide Fragments/immunology ; Rabbits ; Rats ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Fetal alcohol syndrome: embryogenesis in a mouse model (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: When two small doses of ethanol were administered to pregnant mice during the gastrulation stage of embryogenesis, the embryos developed craniofacial malformations closely resembling those seen in the human fetal alcohol syndrome. Striking histological changes appeared in the developing brain (neuroectoderm) within 24 hours of exposure. Decreased development of the neural plate and its derivatives apparently accounts for the craniofacial malformations. The critical exposure period is equivalent to the third week in human pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sulik, K K -- Johnston, M C -- Webb, M A -- DE 02668/DE/NIDCR NIH HHS/ -- DE 05906/DE/NIDCR NIH HHS/ -- RR 05333/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):936-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795717" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Child ; Disease Models, Animal ; Embryo, Mammalian/*drug effects/ultrastructure ; Ethanol/*pharmacology ; Eye Abnormalities ; Female ; Fetal Alcohol Spectrum Disorders/*physiopathology ; Humans ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron, Scanning ; Pregnancy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Efferents to the retina have multiple sources in teleost fish (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: Multiple efferent systems project to the retina in three species of teleost fish investigated with the horseradish peroxidase technique. These animals are the first vertebrates shown to have more than one central nervous system structure projecting to the retina. The connections discovered may reflect a primitive organization of retina-brain interconnections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ebbesson, S O -- Meyer, D L -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):924-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6171033" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axonal Transport ; Efferent Pathways/*physiology ; Fishes ; Horseradish Peroxidase ; Retina/*physiology ; Species Specificity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 38
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    5-Methylcytosine in eukaryotic DNA (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: A small portion of the cytosine residues in the DNA of higher eukaryotes as well as in that of many lowe eukaryotes if methylated. The resulting 5-methylcytosine residues occur in specific in the DNA, usually adjacent to guanine residues on the 3' side. This methylation of eukaryotic DNA has been proposed to function in many ways, including control of transcription, maintenance of chromosome structure, repair of DNA, establishment of preferred sites for mutation, oncogenic transformation, and, in certain systems, protection of DNA against enzymatic degradation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrlich, M -- Wang, R Y -- CA-19942/CA/NCI NIH HHS/ -- GM-26986/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1350-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6262918" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; Animals ; Base Sequence ; Cytosine/*analogs & derivatives/analysis ; DNA/*genetics ; DNA Replication ; DNA Restriction Enzymes/metabolism ; *Genes ; Methylation ; Pyrimidines ; Species Specificity ; Substrate Specificity ; Transcription, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
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    Thyrotropin-releasing hormone improves cardiovascular function in experimental endotoxic and hemorrhagic shock (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: Thyrotropin-releasing hormone significantly improved cardiovascular function when it was injected intravenously into conscious rats subjected to experimental endotoxic or hemorrhagic shock. Because thyrotropin-releasing hormone appears to be a "physiologic: opiate antagonist without effects on pain responsiveness, it may provide therapeutic benefits in the treatment of shock or acute hypotension.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holaday, J W -- D'Amato, R J -- Faden, A I -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):216-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6787704" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/*drug effects ; Disease Models, Animal ; Endotoxins ; Heart Rate/drug effects ; Male ; Rats ; Shock, Hemorrhagic/*physiopathology ; Shock, Septic/*physiopathology ; Thyrotropin-Releasing Hormone/*pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 40
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    beta-Endorphin: possible involvement in the antihypertensive effect of central alpha-receptor activation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-02
    Description: Clonidine and L-alpha-methylnoradrenaline (but not D-alpha-methylnoradrenaline) increase the release of a substance with beta-endorphin immunoreactivity from slices of brainstem of spontaneously hypertensive rats, but not that of normotensive rats. It was reported earlier that opiate antagonists inhibit the hypotensive action of clonidine and alpha-methyldopa in spontaneously hypertensive but not in normotensive rats and that beta-endorphin has hypotensive effects of its own. Together, these findings indicate that release of beta-endorphin by central alpha-receptor agonists may contribute to the antihypertensive action of these drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kunos, G -- Farsang, C -- Ramirez-Gonzales, M D -- New York, N.Y. -- Science. 1981 Jan 2;211(4477):82-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6108611" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic alpha-Agonists/*pharmacology ; Animals ; Brain Stem/*metabolism ; Clonidine/pharmacology ; Disease Models, Animal ; Endorphins/*metabolism ; Hypertension/*physiopathology ; Immunoassay ; Male ; Naloxone/pharmacology ; Nordefrin/pharmacology ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 41
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    Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-28
    Description: Seizures were produced in rat pups by ambient hyperthermia. Seizure threshold temperatures, measured rectally and intracerebrally, increased between 2 and 10 days of age. Electrocortical paroxysmal discharges were confirmed in hyperthermic 6- and 10-day-old pups. The increasing resistance to hyperthermic seizures with maturation and the electroencephalographic changes induced by hyperthermia are similar to those in young children.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holtzman, D -- Obana, K -- Olson, J -- NS 16256/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 28;213(4511):1034-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268407" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Brain/physiopathology ; Disease Models, Animal ; Electroencephalography ; Fever/*complications ; Rats ; Seizures/*physiopathology ; Seizures, Febrile/*physiopathology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 42
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    Temporal coding of species recognition signals in an electric fish (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: An electric fish in the African family Mormyridae recognizes members of its own species by "listening" to electric organ discharges, which are species-specific signatures. Reactions of fish in the field and of individual electroreceptors to both normal and modified computer-synthesized discharges emphasize the importance of the waveform (time-domain cues) in species recognition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hopkins, C D -- Bass, A H -- MH26140/MH/NIMH NIH HHS/ -- NS06309/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):85-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209524" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Communication ; Animals ; Electric Organ/*physiology ; Female ; Fishes/*physiology ; Male ; Sex Factors ; Sexual Behavior, Animal/physiology ; Species Specificity ; Time Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 43
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    Germplasm conservation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russell, E S -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1074, 1076.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6946561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Disease Models, Animal ; Dogs ; *Genetic Engineering ; *Genetics, Medical ; Humans ; Mice ; Mutation ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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