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  • Articles  (12)
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  • Springer  (12)
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  • Articles  (12)
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  • Springer  (12)
  • Annual Reviews
  • Blackwell Publishing Ltd
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Behavior genetics 13 (1983), S. 107-116 
    ISSN: 1573-3297
    Keywords: rat ; sex ; alcohol preference ; biometrical genetics ; triple-test cross ; genetic architecture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Because our previous (1981) simplified triple-test cross analysis of alcohol preference for a 10% (w/v) alcohol solution or water showed failure of the simple additive-dominance genetic model among females, additional breeding was undertaken to produce the full triple-test cross. An L3 tester strain, and F1 cross between the MNR and the ACI strains, previously used as L1 and L2 testers, respectively, was bred and crossed to six strains: RHA, RLA, TMB, TMD, MNR, and ACI. The previous failure of the model was found to be due to inadequate testers sharing common loci, rather than to epistasis. Unbiased estimates of genetic architecture in the females were similar to those already found for males, revealing directional dominance for low alcohol preference.
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  • 2
    ISSN: 1573-3297
    Keywords: food restriction ; litter reduction ; Mus musculus ; nesting ; reproductive effort ; sex ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Female mice of lines divergently selected for thermoregulatory nesting were mated at 5°C and were fed eitherad libitum or restricted diets. Gestation period and litter size at birth were not affected by food restriction, but both fertility and litter size at weaning were significantly reduced by restriction. The reduction in litter size by restricted females was positively associated with the weight of both females and pups at weaning. The pattern of response to food restriction was generally more conservative than that expected on the basis of r-selection predictions. There was also a significant reduction in the proportion of males weaned by restricted females. Differences among the selected lines in both feeding regimes were generally consistent with the hypothesis that thermoregulatory nesting has a positive genetic correlation with Darwinian fitness at low temperatures.
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  • 3
    ISSN: 1573-3297
    Keywords: avoidance conditioning ; rat ; diallel cross ; biometrical genetics ; genetic architecture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract In a study designed to investigate genotype-environment interaction, eight strains of laboratory rats were crossbred in a replicated diallel cross employing infantile stimulation and its absence as environment treatments. This paper reports on measures of the acquisition of two-way escape-avoidance conditioning, comprising number of avoidances, avoidance and escape latencies, and intertrial and presessional crossings, which were subjected to biometrical genetical analysis, all but the last successfully. Additive variation was prominent throughout and some measures showed directional dominance. Effects of stimulation were seen in avoidance number and crossings. The analysis of avoidances by successive blocks of trials using covariance:variance graphs revealed differences in the way the strains varied with respect to the changing relationships of proportions of dominant and recessive alleles governing this behavior. The results are discussed in the light of previous data and of their evolutionary implications.
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  • 4
    ISSN: 1573-3297
    Keywords: biometrical genetics ; genetic architecture ; evolution ; rat ; wild population ; escape-avoidance conditioning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The interest of biometrical geneticists in the genetic architecture of behavior is explained with reference to the additive, dominance, and epistatic components of variation and their relation to evolutionary pressures. For one phenotype, escape-avoidance conditioning inRattus norvegicus, a fairly complete description of its genetic architecture has been gradually built and the major conclusions from four studies of this phenotype are reported: a selection study initially demonstrated the presence of large amounts of additive genetic variation and produced phenotypically extreme lines needed for later work; a diallel cross provided the opportunity for detailed examination of the dominance effects; a triple test cross permitted a similar examination of epistatic effects; and finally, another triple test cross using wild rats provided a confirmatory first attempt to test the assumption that a wild population's genetic architecture did not differ markedly from that found in laboratory populations. In relating the genetic findings to the evolutionary significance of behaviors in the escape-avoidance paradigm, it is argued that interspecific comparisons might play a major role.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Behavior genetics 11 (1981), S. 517-531 
    ISSN: 1573-3297
    Keywords: rat ; alcohol preference ; biometrical genetics ; simplified triple-test cross ; genetic architecture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Reanalyses of first-degree biometrical genetic data from previous studies of alcohol preference in the mouse revealed little consistency beyond a basic additive genetic component. A simplified triple-test cross in the rat investigated the genetic architecture of alcohol preference for a 10% (w/v) alcohol solution or water. An initial survey of eight selected and inbred strains identified high- and low-scoring strains, the MNR and the ACI, respectively, which were crossed as tester lines to six strains (the RHA, RLA, TMB, TMD, MNR, and ACI) to produce the required set of largely F1 families. The additive-dominance model proved adequate for males, and directional dominance for low alcohol preference was found on all three measures: alcohol intake, alcohol preference ratio, and alcohol calorie contribution ratio. For females the model was adequate only for alcohol preference ratio, which showed ambidirectional dominance. The relevance of such genetic architecture to an animal model of alcoholism and to the evolution of alcohol drinking in the rat is discussed.
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  • 6
    Electronic Resource
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    Springer
    Behavior genetics 11 (1981), S. 267-272 
    ISSN: 1573-3297
    Keywords: Mus musculus ; genetic correlation ; maternal nesting ; thermoregulatory nesting ; artificial selection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The genetic correlation between maternal nesting (weight of cotton used in the nest built on the day of parturition) and thermoregulatory nesting (total weight of individual nests built on four consecutive days) was estimated from the correlated response of the former to selection for the latter. The best estimate was rA=0.58±0.32, indicating a substantial amount of common genetic influence. Indirect selection seems to have produced a greater response in maternal nesting than could have been achieved by direct selection.
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  • 7
    Electronic Resource
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    Springer
    Behavior genetics 11 (1981), S. 281-287 
    ISSN: 1573-3297
    Keywords: Mus musculus ; time of eye-opening ; albino vs. pigmented coisogenic C57 mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Black and albino littermate mice of the same inbred strain were compared to see if precocious development of the visual system, as indicated by the first detected eye-opening within a litter, is due to alleles at the albino locus. In 32 litters of C57BL/6J-c2J mice the frequency of first detected eye-openings in albinos was not significant; there were no sex or maternal effects. In 16 litters of B10.D2/nSn-c4J mice the frequency of first detected eye-openings in male, but not female, blacks was significant; there were no maternal effects. The results surely do not rule out the possibility of abnormalities in the timing of the developmental sequence of the visual system in albinos; the entire sequence must be examined with appropriate genetic controls.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Behavior genetics 11 (1981), S. 115-126 
    ISSN: 1573-3297
    Keywords: artificial selection ; Mus musculus ; aggression ; attack latency ; mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Artificial selection for short and long attack latency levels in wild maleMus musculus over 11 generations was successful for short latencies. The realized heritability of 0.30 is comparable to those found in other selection studies on aggression. In part selection may have been for faster ontogenetic development of short attack latencies. Four attempts to select for longer attack latencies failed because the lines died out immediately or within two generations for unknown reasons. But neither the physical condition of the animals nor their behavior appeared to have been the cause. Female aggressiveness as measured in female-female encounters was not affected by the selection exerted on the males. This suggests that no genetic correlation exists between aggressiveness of males and females, confirming results of P. D. Ebert and J. S. Hyde [(1976).Behav. Genet. 6:291–304] obtained in a selection experiment on aggression using females.
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  • 9
    Electronic Resource
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    Springer
    Behavior genetics 11 (1981), S. 437-444 
    ISSN: 1573-3297
    Keywords: rat ; linkage ; genetics ; gene ; map
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Our genetic knowledge of a species is reflected in the state of its gene map. Although still primitive, relative to the gene map of the mouse, great strides have been made in recent years in developing the gene map of the rat and nine linkage groups have now been defined. Mapping by conventional backcrossing methods has been supplemented with parasexual methods using somatic cell hybrids. Use of recombinant-inbred strains has contributed significantly to the development of the mouse map and the technique holds promise for the future expansion of the rat map. Of great interest are comparative gene mapping and the relationship of linkage groups of the rat to those of other species. At present the linkage groups of the rat and the mouse reflect a high degree of conservation. This is surprising since chromosome banding patterns of the two species show but 40% homology.
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  • 10
    Electronic Resource
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    Springer
    Behavior genetics 11 (1981), S. 445-468 
    ISSN: 1573-3297
    Keywords: rat ; inbred strains ; behavioral selection ; coat genes ; alloantigenic alleles ; characteristic behaviors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Origins of the principal lines ofRattus norvegicus used in behavior genetic research are identified. Broad descriptions are provided for 15 of the Har strains and substrains of well-established inbred lines and behaviorally selected stocks. Marker genes are identified for coat and major histocompatibility complex (MHC) loci. Detailed characteristics are summarized for 12 of these lines using a comprehensive behavioral test battery composed of a variety of measures of expressive behavior, learning, and physiological characteristics.
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  • 11
    Electronic Resource
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    Springer
    Behavior genetics 11 (1981), S. 145-151 
    ISSN: 1573-3297
    Keywords: Bruchidae ; Callosobruchus ; Coleoptera ; nonadditive inheritance ; oviposition behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract As a result of different feeding regimens, two laboratory populations of the beetleCallosobruchus maculatus Fab. developed different rates of oviposition. The behavior of the F1 hybrids cannot be explained with an additive model of inheritance. The unusual pattern of inheritance suggests a sex-related factor(s) and a two-factor interaction.
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  • 12
    Electronic Resource
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    Springer
    Behavior genetics 11 (1981), S. 209-225 
    ISSN: 1573-3297
    Keywords: Mus musculus ; activity ; nest return ; open field ; early behavior ; domestication ; genotype x age interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract An 8×8 diallel analysis of locomotor activity related to nest return in mice just prior to eye opening indicated a pattern of dominance toward high activity, with little additive genetic variance. Groups of laboratory-reared wild mice did not differ from each other or from the diallel mean, suggesting little relaxation of selection toward rapid nest return during domestication. In contrast to the nest return situation, an eight-strain triple test-cross analysis of locomotion in a test environment unlikely to be encountered by 11-day-old mice indicated only additive genetic variance, with no evidence of dominance for increased activity. When measured in an ecologically relevant environment, the nature of genetic variation appears to change with age in a manner concordant with what one would intuitively assume to be adaptive behavior at each stage of development.
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