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  • Kinetics  (19)
  • American Association for the Advancement of Science (AAAS)  (19)
  • American Physical Society
  • Annual Reviews
  • International Union of Crystallography (IUCr)
  • 1980-1984
  • 1975-1979  (19)
  • 1979  (19)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (19)
  • American Physical Society
  • Annual Reviews
  • International Union of Crystallography (IUCr)
  • Springer  (4)
    • +
Years
  • 1980-1984
  • 1975-1979  (19)
Year
  • 1
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    [3H]GABA binding in brains from Huntington's chorea patients: altered regulation by phospholipids? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Binding sites for tritum-labeled gamma-aminobutyric acid (GABA) in cerebellar cortex of Huntington's chorea patients have an increased affinity but unaltered maximum capacity as compared to binding sites in tissue from control patients. A similar binding pattern is produced in control membranes by treatment with Triton X-100, phospholipase C, or glycerophosphoethanolamine. Thus, it is likely that phospholipids or their metabolites regulate the accessibility of the GABA binding site and that this regulation is abnormal in Huntington's chorea.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lloyd, K G -- Davidson, L -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1147-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224459" target="_blank"〉PubMed〈/a〉
    Keywords: Cerebellar Cortex/*metabolism ; Humans ; Huntington Disease/*metabolism ; Kinetics ; Membrane Lipids ; Phosphatidylethanolamines/physiology ; Polyethylene Glycols/pharmacology ; Receptors, Neurotransmitter/drug effects/*metabolism ; gamma-Aminobutyric Acid/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Intercellular communication in pancreatic islet monolayer cultures: a microfluorometric study (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Single islet cells in monolayer cultures of neonatal rat pancreas were microinjected with fluorescein and scanned topographically by microfluorometry. Fluorescein spread from an injected islet cell directly into neighboring islet cells, and, in the presence of 16.7 millimolar glucose, significantly more islet cells communicated with the injected cell than in glucose-free medium. Islet cells were also microinjected with glycolytic substrates and activators that produced transient changes in cellular levels of reduced pyridine nucleotides-nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate [NAD(P)H]. Changes in NAD(P)H fluorescence were observed in islet cells incubated first for 18 hours in very low glucose concentrations and then in a glucose-free medium and injected with glycolytic substrates and activators; however, little change of fluorescence occurred in adjacent islet cells. In contrast, after adding 16.7 millimolar glucose to the medium, injection of glycolytic substrates and activators produced transient changes in NAD(P)H fluorescence in the injected cell and in neighboring cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kohen, E -- Kohen, C -- Thorell, B -- Mintz, D H -- Rabinovitch, A -- New York, N.Y. -- Science. 1979 May 25;204(4395):862-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/35828" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Communication/drug effects ; Fluoresceins ; Glucose/pharmacology ; Glycolysis ; Islets of Langerhans/cytology/*physiology ; Kinetics ; NAD/metabolism ; NADP/metabolism ; Rats ; Spectrometry, Fluorescence
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  • 3
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    A structural model for the kinetic behavior of hemoglobin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: The tertiary structures of all liganded hemoglobins in the R state differ in detail. Steric hindrance arising from nonbonded ligand-globin interactions affects the binding of ligands such as CO and cyanide which preferentially form linear axial complexes to heme; these ligands bind in a strained off-axis configuration. Ligands such as O2 and NO, which preferentially form bent complexes, encounter less steric hindrance and can bind in their (preferred) unstrained configuration. Linear complexes distort the ligand pockets in the R state (and by inference, in the T state) more than bent complexes. These structural differences between linear and bent complexes are reflected in the kinetic behavior of hemoglobin. Structural interpretation of this kinetic behavior indicates that the relative contributions of nonbonded ligand-globin interactions and nonbonded heme interactions to transition state free energies differ for linear and bent ligands. The relative contributions of these interactions to the free energy of cooperativity may also differ for linear and bent ligands. Thus the detailed molecular mechanism by which the affinity of heme is regulated differs for different ligands.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moffat, K -- Deatherage, J F -- Seybert, D W -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1035-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493990" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Animals ; Heme/*metabolism ; Hemoglobins/metabolism ; Horses ; Kinetics ; Ligands ; Oxygen/*metabolism ; Oxyhemoglobins/*metabolism ; Protein Conformation ; Stereoisomerism ; Structure-Activity Relationship
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  • 4
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    Octopamine receptors, adenosine 3',5'-monophosphate, and neural control of firefly flashing (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-05
    Description: An adenylate cyclase activated as much as 25-fold by low concentrations of octopamine has been identified in the firefly lantern. The relative potency of octopamine and various other amines in stimulating this enzyme, and effects of antagonists in blocking octopamine activation, correlate well with the known effects of these agents in affecting light production. In addition to suggesting a role for adenosine 3',5'-monophosphate (or pyrophosphate) in the neural control of firefly flashing, identification of this potent enzyme should facilitate the characterization of phenylethylamine receptors in excitable tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathanson, J A -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):65-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214856" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Beetles/*physiology ; Catecholamines/pharmacology ; Cyclic AMP/*biosynthesis ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Kinetics ; Octopamine/*pharmacology ; Phentolamine/pharmacology ; Propranolol/pharmacology ; Receptors, Cell Surface/*drug effects ; Receptors, Neurotransmitter/*drug effects ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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  • 5
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    Endogenous inhibitor of colchicine-tubulin binding in rat brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: A competitive inhibitor of colchicine binding to tubulin has been found in rat brain. Most of the inhibitor is associated with microsomes but some inhibitor, with an apparent molecular weight of approximately 250,000, is found in the cytosol. Both the microsomal and cytosol inhibitors are heat- and trypsin-sensitive, indicating that a protein moiety is required for activity. The microsomes bind tubulin directly; the microsomal and cytosol fractions both inhibit microtubule assembly in vitro. The inhibitor may function in the living cell to bind and sequester non-polymerized tubulin. Regulation of tubulin attachment to microsomes could then control the concentration of cytosolic tubulin available for microtubule assembly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sherline, P -- Schiavone, K -- Brocato, S -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):593-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451622" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Colchicine/*metabolism ; Cytosol/physiology ; Glycoproteins/*metabolism ; Kinetics ; Microsomes/metabolism ; Microtubules/ultrastructure ; Nerve Tissue Proteins/*physiology ; Protein Binding/drug effects ; Rats ; Tubulin/*metabolism
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  • 6
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    4-aminobutyrate:2-oxoglutarate aminotransferase in blood platelets (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Platelet lysates obtained from blood of humans, dogs, and rats catalyzed the transamination of 4-aminobutyrate with 2-oxoglutarate as cosubstrate. Human platelet 4-aminobutyrate:2-oxoglutarate aminotransferase (36.5 +/- 3.2 picomoles per minute per milligram of platelet protein) resembled the brain enzyme in kinetic properties and in response to cofactors and inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, H L -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):696-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462176" target="_blank"〉PubMed〈/a〉
    Keywords: 4-Aminobutyrate Transaminase/*blood ; Animals ; Blood Platelets/*enzymology ; Brain/enzymology ; Dogs ; Enzyme Activation/drug effects ; Humans ; Kinetics ; Pyridoxal Phosphate/pharmacology ; Rats ; Substrate Specificity ; Transaminases/*blood ; gamma-Aminobutyric Acid/blood
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  • 7
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    Inhibition of histaminase release from human granulocytes by products of histaminase activity (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: Imidazoleacetic acid, a product of the action of histaminase (E.C. 1.4.3.6) on histamine, inhibits specific release of histaminase from human peripheral blood granulocytes with an inhibition constant between 5 X 10(-9)M and 1 X 10(-8)M. Hence, modulation of enzyme release is indirectly mediated by the activity of the enzyme.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herman, J J -- Brenner, J K -- Colten, H R -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):77-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113872" target="_blank"〉PubMed〈/a〉
    Keywords: Acetates/pharmacology ; Amine Oxidase (Copper-Containing)/*blood ; Biological Transport/drug effects ; Feedback ; Granulocytes/*enzymology ; Humans ; Imidazoles/*pharmacology ; Kinetics
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  • 8
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    Diffusion-like process can account for protein secretion by the pancreas (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-15
    Description: When fluid secretion by the pancreas was mechanically blocked, amylase secretion into the duct ceased. When flow was reduced in a graded fashion by the application of a back pressure, amylase output was reduced proportionately and amylase concentration in secretion was maintained constant. Thus, the secretion of digestive enzyme from the cell into the duct appears to be dependent upon the concentration of enzyme in the duct system. This behavior is most simply explained by diffusion-like (concentration dependent, bidirectional) fluxes of digestive enzyme across the plasma membrane. A unidirectional process, such as exocytosis, whose rate should be unaffected by fluid flow, cannot readily explain these results.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Isenman, L D -- Rothman, S S -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1212-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451566" target="_blank"〉PubMed〈/a〉
    Keywords: Amylases/*secretion ; Animals ; Biological Transport ; Diffusion ; Exocytosis ; Hydrostatic Pressure ; Kinetics ; Pancreas/*secretion ; Rabbits ; Water-Electrolyte Balance
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  • 9
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    Calmodulin activation of adenylate cyclase in pancreatic islets (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valverde, I -- Vandermeers, A -- Anjaneyulu, R -- Malaisse, W J -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):225-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/225798" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Calcium/*physiology ; Calcium-Binding Proteins/*metabolism ; Calmodulin/*metabolism ; Cell Membrane/metabolism ; Cyclic AMP/metabolism ; Egtazic Acid/metabolism ; Enzyme Activation ; Female ; Glucose/pharmacology ; Insulin/*secretion ; Islets of Langerhans/*enzymology ; Kinetics ; Rats
    Print ISSN: 0036-8075
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  • 10
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    Prolactin receptors in Rana catesbeiana during development and metamorphosis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Specific binding of ovine prolactin was found in microsomal preparations of tail, gill, and kidney of the bullfrog Ran catesbeiana. Binding by larval and adult liver and by kidney before larval stage XVII was low or nondetectable. Renal binding increased during metamorphic climax and in response to treatment with thyroid hormone. The emergence of renal binding of prolactin may signify a shift in the hormone's participation in the control of hydromineral homeostasis from the gill, which is resorbed, to the kidney. A renal action of prolactin during climax may facilitate metamorphosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, B A -- Nicoll, C S -- New York, N.Y. -- Science. 1979 May 25;204(4395):851-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/220708" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gills/metabolism ; Kidney/metabolism ; Kinetics ; Liver/metabolism ; *Metamorphosis, Biological ; Microsomes/metabolism ; Prolactin/*physiology ; Rana catesbeiana/*growth & development ; Receptors, Cell Surface/*metabolism ; Tail/metabolism ; Thyroxine/pharmacology ; Water-Electrolyte Balance
    Print ISSN: 0036-8075
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  • 11
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    Erythrosin B inhibits dopamine transport in rat caudate synaptosomes (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: Erythrosin B is a member of a class of fluorescein dyes that are suggested to elicit hyperkinesis when ingested by susceptible children. We found that erythrosin B inhibits dopamine uptake in rat caudate synaptosomes "uncompetitively" in the 10- to 800-micromolar range. Half maximal inhibition of uptake occurred at 45 micromolar. Uncompetitive inhibition denotes a decrease in efficacy of the dopamine membrane transport mechanism with an increase in affinity of dopamine to the carrier. Erythrosin B also decreased nonsaturable binding of dopamine to the synaptosome membrane. The inhibitory action of erythrosin B on dopamine uptake is consistent with the hypothesis that erythrosin B can act as a central excitatory agent able to induce hyperkinetic behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lafferman, J A -- Silbergeld, E K -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):410-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451609" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Caudate Nucleus/drug effects/*metabolism ; Dopamine/*metabolism ; Erythrosine/*pharmacology ; Fluoresceins/*pharmacology ; Kinetics ; Rats ; Synaptosomes/drug effects/*metabolism
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  • 12
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    beta1- and beta2-Adrenergic receptors in rat cerebral cortex are independently regulated (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Repeated administration of the tricyclic antidepressant desmethylimipramine to adult rats for 10 days caused a 40% decrease in the density of beta1-adrenergic receptors in the cerebral cortex but had no effect on the density of beta2-adrenergic receptors. Conversely, destruction of noradrenergic neurons by administration of 6-hydroxydopamine to neonatal rats caused a 64% increase in the density of beta1-adrenergic receptors in adult cerebral cortex with no change in the density of beta2-adrenergic receptors. These results suggest that the beta-adrenergic receptors in rat cortex involved in neuronal function are primarily of the beta1 subtype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Minneman, K P -- Dibner, M D -- Wolfe, B B -- Molinoff, P B -- New York, N.Y. -- Science. 1979 May 25;204(4395):866-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/35829" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic beta-Agonists/metabolism ; Animals ; Binding, Competitive ; Cerebral Cortex/*metabolism ; Cyclic AMP/metabolism ; Desipramine/pharmacology ; Hydroxydopamines/pharmacology ; Kinetics ; Rats ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/drug effects/*metabolism
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  • 13
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    Thyroid hormone action at the cellular level (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: A large body of circumstantial evidence suggests that the basic unit of thyroid hormone action is the triiodothyronine nuclear receptor complex. This complex stimulates the formation, directly or indirectly, of a diversity of messenger RNA (mRNA) sequences. A generalized increase in mRNA as well as a disproportionate increase in a limited number of RNA sequences have been demonstrated. Regulation of thyroid hormone effects may be carried out largely at a local cellular level. Highly selective alterations in sensitivity to the triiodothyronine nuclear receptor complex may occur at specific target genes. Metabolic factors and hormones participate in such regulation. In a given tissue, alterations in the total number of receptor sites has not been shown to be useful as an index of thyroid hormone response, and local modulation of the response to the triiodothyronine receptor complex by a variety of factors other than triiodothyronine may be carried out at a postreceptor level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oppenheimer, J H -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):971-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218285" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Energy Metabolism ; Humans ; Kinetics ; Lipid Metabolism ; Protein Binding ; RNA, Messenger/biosynthesis ; Receptors, Cell Surface/*physiology ; Thyroid Gland/physiology ; Thyroxine/metabolism ; Tissue Distribution ; Triiodothyronine/*physiology
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  • 14
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    Heparin neutralization of PGI2: effects upon platelets (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-03
    Description: Heparin neutralizes the inhibitory effect of prostacyclin (PGI2) on platelet aggregation. The PGI2-induced enhancement of platelet cyclic adenosine monophosphate levels is also inhibited. The mechanism appears to involve a direct interaction in which heparin neutralizes the inhibitory effects of PGI2 on platelet aggregation but, at the same time, does not lose its own anticoagulant activity. These findings may explain instances in which heparin infusions have been reported to produce hyperaggregation of platelets, thrombotic episodes, and thrombocytopenia in patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saba, H I -- Saba, S R -- Blackburn, C A -- Hartmann, R C -- Mason, R G -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):499-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377493" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/pharmacology ; Blood Coagulation/drug effects ; Epoprostenol/*pharmacology ; Heparin/*pharmacology ; Humans ; Kinetics ; Platelet Aggregation/*drug effects ; Prostaglandins/*pharmacology ; Thrombin/physiology
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  • 15
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    Oxytocin receptors: triggers for parturition and lactation? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Specific binding of tritiated oxytocin to uterine receptors of pregnant rats increases dramatically at term and is maximal during labor. In mammary glands the increase in binding is gradual, reaching a maximum during the lactation period. Concomitant changes in the sensitivity of the uterus and mammary gland to oxytocin indicate that the receptor concentration is of functional significance. Oxytocin receptors, therefore, may regulate the response of the target organs to circulating oxytocin and thereby control the onset of labor and lactation. Ovarian steroids participate in the regulation of oxytocin receptors in a manner as yet unclarified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soloff, M S -- Alexandrova, M -- Fernstrom, M J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1313-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221972" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/blood ; Female ; Kinetics ; *Labor, Obstetric ; *Lactation ; Mammary Glands, Animal/metabolism ; Myometrium/*metabolism ; Oxytocin/blood/*metabolism ; Pregnancy ; Progesterone/blood ; Receptors, Cell Surface/*metabolism ; Uterus/*metabolism
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  • 16
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    Meiotic maturation in Xenopus laevis oocytes initiated by insulin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Insulin can induce meiotic division in Xenopus laevis oocytes. This effect shows the specificity expected of a receptor-mediated mechanism. It is potentiated by ethynylestradiol, a steroid antagonist of pregesterone (the natural hormone that provokes meiosis). The Xenopus laevis oocytes may serve as a model for the study of the poorly understood effect of insulin on cell division.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉El-Etr, M -- Schorderet-Slatkine, S -- Baulieu, E E -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1397-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472755" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Cholera Toxin/pharmacology ; Cycloheximide/pharmacology ; Ethinyl Estradiol/pharmacology ; Female ; Insulin/*pharmacology ; Kinetics ; Meiosis/*drug effects ; Oocytes/*drug effects ; Oogenesis/*drug effects ; Ovum/*drug effects ; Progesterone/pharmacology ; Receptor, Insulin/drug effects ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 17
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    A source of nonshivering thermogenesis in fur seal skeletal muscle (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: The mitochondria from the subscapular muscle of naturally cold-stressed 10- to 15-year-old northern fur seals (Callorhinus ursinus) were loosely coupled upon isolation, whereas the mitochondria from the same muscle of warm-acclimated pups of the same age were tightly coupled. Thus, loose-coupled muscle mitochondria might provide an important vehicle for nonshivering thermogenesis in this species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grav, H I -- Blix, A S -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):87-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219477" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/metabolism ; Animals ; Animals, Suckling ; *Body Temperature Regulation ; Cold Temperature ; Electron Transport Complex IV/metabolism ; Energy Metabolism ; Fur Seals/*physiology ; Kinetics ; Mitochondria, Muscle/physiology ; Muscles/*physiology ; Oxygen Consumption ; Pinnipedia/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 18
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    Acridine araphanes: a new class of probe molecules for biological systems (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: The bis-acridine ring system forms the basis for new biophysical probes of novel stereochemistry. Spectral data indicate that certain alkylene bridged bis-9-aminoacridines have a parallel plane conformation of predictable interplane distance. The parallel plane conformation is independent of solvent and thus is different from nucleic acid systems. This stable conformation allows these compounds to be used as sensitive "rulers" for describing binding site geometry in cholinergic enzymes and in the delineation of the mechanism of allosteric control in acetylcholinesterase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Himel, C M -- Taylor, J L -- Pape, C -- Millar, D B -- Christopher, J -- Kurlansik, L -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1277-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472743" target="_blank"〉PubMed〈/a〉
    Keywords: *Acetylcholinesterase/metabolism ; *Acridines ; Binding Sites ; Kinetics ; Molecular Conformation ; Phosphorylation ; Protein Conformation ; Spectrophotometry, Ultraviolet
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 19
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    Cellular applications of 31P and 13C nuclear magnetic resonance (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: High-resolution nuclear magnetic resonance (NMR) studies of cells and purified mitochondria are discussed to show the kind of information that can be obtained in vivo. In suspensions of Escherichia coli both phosphorus-31 and carbon-13 NMR studies of glycolysis and bioenergetics are presented. In rat liver cells the pathways of gluconeogenesis from carbon-13-labeled glycerol are followed by carbon-13 NMR. In the intact liver cells cytosolic and mitochondrial pH's were separately measured by phosphorus-31 NMR. In purified mitochondria the internal and external concentrations of inorganic phosphate, adenosine diphosphate, and adenosine triphosphate were determined by phosphorus-31 NMR while the pH difference across the membrane was measured simultaneously.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shulman, R G -- Brown, T R -- Ugurbil, K -- Ogawa, S -- Cohen, S M -- den Hollander, J A -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):160-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36664" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/*metabolism ; Adenosine Triphosphate/*metabolism ; Animals ; Carbon Isotopes ; Escherichia coli/metabolism ; Hydrogen-Ion Concentration ; Kinetics ; Liver/metabolism ; Magnetic Resonance Spectroscopy/*methods ; Mitochondria/metabolism ; Phosphates/*metabolism ; Phosphorus Isotopes ; Rats ; Sugar Phosphates/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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